instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Second, we demonstrate that hMre11B, like the yeast Mre11 protein, dimerizes in vivo in a yeast two-hybrid system.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11]
<Options>: A: or9m1b (mus musculus) (aka olfactory receptor family 9 subfamily m member 1b)
B: mre11 (drosophila melanogaster) (igf-ii mrna-binding protein (drosophila melanogaster)) (aka igf-ii mrna-binding protein)
C: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair n... | [C; K] |
<Instruct>: Given the context 'Second, we demonstrate that hMre11B, like the yeast Mre11 protein, dimerizes in vivo in a yeast two-hybrid system.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11]
<Options>: A: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
B: hsd11b (homo sapiens) (aka hydroxysteroid 11-beta dehydrogenase 1)
C: olfactory receptor family 11 subfamily h member 12b (bos taurus) (aka olfactory receptor family 11 subfamily h ... | [A; K] |
<Instruct>: Given the context 'This dimerization requires the C-terminal one-third of hMre11B protein, which includes the 28 amino acids absent in hMre11.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [hmre11b; hmre11]
<Options>: A: hbre1 (homo sapiens) (aka ring finger protein 20)
B: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
C: or4c11b (mus musculus) (aka olfactory receptor family 4 subfamily c member 11b)
D: hsd11b (homo sapiens) (aka hydroxysteroid 11... | [B; J] |
<Instruct>: Given the context 'This dimerization requires the C-terminal one-third of hMre11B protein, which includes the 28 amino acids absent in hMre11.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [hmre11b; hmre11]
<Options>: A: or9m1b (mus musculus) (aka olfactory receptor family 9 subfamily m member 1b)
B: or4c11b (mus musculus) (aka olfactory receptor family 4 subfamily c member 11b)
C: ccr4-not transcription complex, subunit 11 (mus musculus) (aka ccr4-not transcription complex, subunit 11)
D: hb... | [I; I] |
<Instruct>: Given the context 'This dimerization requires the C-terminal one-third of hMre11B protein, which includes the 28 amino acids absent in hMre11.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [hmre11b; hmre11]
<Options>: A: hmnr11 (homo sapiens) (aka reticulon 2)
B: olfactory receptor family 52 subfamily e member 19b (mus musculus) (aka olfactory receptor family 52 subfamily e member 19b)
C: or9m1b (mus musculus) (aka olfactory receptor family 9 subfamily m member 1b)
D: ccr4-not transcription c... | [J; K] |
<Instruct>: Given the context 'However, hMre11B does not interact with Mre11, Rad50 and Xrs2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11; rad50; xrs2]
<Options>: A: mre11 (mus musculus) (aka mre11a homolog a, double strand break repair nuclease)
B: or11h4b (mus musculus) (aka olfactory receptor family 11 subfamily h member 4b)
C: xrn2 (saccharomyces cerevisiae s288c) (aka ssrna exonuclease rat1)
D: olfactory receptor family 8... | [L; U; Q; R] |
<Instruct>: Given the context 'However, hMre11B does not interact with Mre11, Rad50 and Xrs2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11; rad50; xrs2]
<Options>: A: dna repair protein xrcc2-like (xenopus tropicalis) (aka dna repair protein xrcc2-like)
B: mre11 homolog, double strand break repair nuclease (rattus norvegicus) (aka mre11 homolog, double strand break repair nuclease)
C: olfactory receptor family 8 subfamily b mem... | [S; U; L; G] |
<Instruct>: Given the context 'However, hMre11B does not interact with Mre11, Rad50 and Xrs2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11; rad50; xrs2]
<Options>: A: xrn2 (homo sapiens) (aka 5'-3' exoribonuclease 2)
B: xrp2 (homo sapiens) (aka rp2 activator of arl3 gtpase)
C: mre11 homolog, double strand break repair nuclease (rattus norvegicus) (aka mre11 homolog, double strand break repair nuclease)
D: xrn2 (saccharomyces ce... | [I; T; P; T] |
<Instruct>: Given the context 'However, hMre11B does not interact with Mre11, Rad50 and Xrs2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11; rad50; xrs2]
<Options>: A: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
B: rad-50 (drosophila melanogaster) (aka rad50)
C: mre11a homolog a, double strand break repair nuclease (mus musculus) (aka mre11a homolog a, double strand break repair n... | [A; U; H; O] |
<Instruct>: Given the context 'However, hMre11B does not interact with Mre11, Rad50 and Xrs2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11; rad50; xrs2]
<Options>: A: rad50 (xenopus tropicalis) (aka rad50 homolog, double strand break repair protein)
B: mre11 homolog, double strand break repair nuclease (gallus gallus) (aka mre11 homolog, double strand break repair nuclease)
C: xrg2 (homo sapiens) (aka xk related x-linked)
D: mr... | [G; U; R; H] |
<Instruct>: Given the context 'Hence, the lack of protein-protein interaction between hMre11B and the yeast Mre11, Rad50, and Xrs2 may explain the inability of hMRE11B to complement the yeast mre11 mutants.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [hmre11b; mre11; rad50; xrs2]
<Options>: A: xrs2p (saccharomyces cerevisiae s288c) (aka xrs2p)
B: x-ray repair cross complementing 2 (homo sapiens) (aka x-ray repair cross complementing 2)
C: rad50 (saccharomyces cerevisiae s288c) (aka mrx complex dna-binding subunit)
D: mre11a homolog a, double strand brea... | [O; U; C; A] |
<Instruct>: Given the context 'Hence, the lack of protein-protein interaction between hMre11B and the yeast Mre11, Rad50, and Xrs2 may explain the inability of hMRE11B to complement the yeast mre11 mutants.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [hmre11b; mre11; rad50; xrs2]
<Options>: A: olfactory receptor family 11 subfamily h member 4b (mus musculus) (aka olfactory receptor family 11 subfamily h member 4b)
B: mre11 homolog, double strand break repair nuclease (bos taurus) (aka mre11 homolog, double strand break repair nuclease)
C: rad50 (drosoph... | [O; U; G; E] |
<Instruct>: Given the context 'Hence, the lack of protein-protein interaction between hMre11B and the yeast Mre11, Rad50, and Xrs2 may explain the inability of hMRE11B to complement the yeast mre11 mutants.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [hmre11b; mre11; rad50; xrs2]
<Options>: A: xrn2 (saccharomyces cerevisiae s288c) (aka ssrna exonuclease rat1)
B: mre11 (drosophila melanogaster) (meiotic recombination 11 (drosophila melanogaster)) (aka meiotic recombination 11)
C: dna repair protein rad50-like (xenopus tropicalis) (aka dna repair protein ... | [M; U; T; P] |
<Instruct>: Given the context 'Hence, the lack of protein-protein interaction between hMre11B and the yeast Mre11, Rad50, and Xrs2 may explain the inability of hMRE11B to complement the yeast mre11 mutants.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [hmre11b; mre11; rad50; xrs2]
<Options>: A: dna repair protein rad50-like (xenopus tropicalis) (aka dna repair protein rad50-like)
B: xrg2 (homo sapiens) (aka xk related x-linked)
C: mre11 homolog, double strand break repair nuclease (xenopus tropicalis) (aka mre11 homolog, double strand break repair nuclea... | [N; T; T; I] |
<Instruct>: Given the context 'Hence, the lack of protein-protein interaction between hMre11B and the yeast Mre11, Rad50, and Xrs2 may explain the inability of hMRE11B to complement the yeast mre11 mutants.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [hmre11b; mre11; rad50; xrs2]
<Options>: A: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
B: rad50 (xenopus laevis) (aka rad50 homolog, double strand break repair protein l homeolog)
C: rad-50 (drosophila melanogaster) (aka rad50)
D: or9m1b (mus musculus) (aka ... | [A; U; F; L] |
<Instruct>: Given the context 'Hence, the lack of protein-protein interaction between hMre11B and the yeast Mre11, Rad50, and Xrs2 may explain the inability of hMRE11B to complement the yeast mre11 mutants.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [hmre11b; mre11]
<Options>: A: olfactory receptor family 11 subfamily h member 12b (bos taurus) (aka olfactory receptor family 11 subfamily h member 12b)
B: mre11 double strand break repair nuclease (homo sapiens) (aka mre11 double strand break repair nuclease)
C: mre11 (mus musculus) (aka mre11a homolog a,... | [D; K] |
<Instruct>: Given the context 'Hence, the lack of protein-protein interaction between hMre11B and the yeast Mre11, Rad50, and Xrs2 may explain the inability of hMRE11B to complement the yeast mre11 mutants.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [hmre11b; mre11]
<Options>: A: hsd11b (homo sapiens) (aka hydroxysteroid 11-beta dehydrogenase 1)
B: olfactory receptor family 8 subfamily b member 12b (mus musculus) (aka olfactory receptor family 8 subfamily b member 12b)
C: mre11 homolog, double strand break repair nuclease (gallus gallus) (aka mre11 hom... | [F; K] |
<Instruct>: Given the context 'We rule out the hypothesis that the lack of interaction and, in turn of complementation, is due to the absence of sequence homology at the C-terminal domain of hMre11B compared to the yeast Mre11.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [hmre11b; mre11]
<Options>: A: mre11 homolog, double strand break repair nuclease (gallus gallus) (aka mre11 homolog, double strand break repair nuclease)
B: olfactory receptor family 52 subfamily e member 19b (mus musculus) (aka olfactory receptor family 52 subfamily e member 19b)
C: mre11 (homo sapiens) (... | [F; K] |
<Instruct>: Given the context 'We rule out the hypothesis that the lack of interaction and, in turn of complementation, is due to the absence of sequence homology at the C-terminal domain of hMre11B compared to the yeast Mre11.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [hmre11b; mre11]
<Options>: A: mre11 (mus musculus) (aka mre11a homolog a, double strand break repair nuclease)
B: olfactory receptor family 11 subfamily h member 4b (mus musculus) (aka olfactory receptor family 11 subfamily h member 4b)
C: mre11 homolog, double strand break repair nuclease (rattus norvegic... | [J; J] |
<Instruct>: Given the context 'We rule out the hypothesis that the lack of interaction and, in turn of complementation, is due to the absence of sequence homology at the C-terminal domain of hMre11B compared to the yeast Mre11.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [hmre11b; mre11]
<Options>: A: mre11 homolog, double strand break repair nuclease (xenopus tropicalis) (aka mre11 homolog, double strand break repair nuclease)
B: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
C: or9m1b (mus musculus) (aka olfactory receptor fam... | [B; K] |
<Instruct>: Given the context 'Instead, we propose that the C-terminus of hMre11B participates in protein-protein interaction and functions in a species-specific manner.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [hmre11b]
<Options>: A: or2h1b (mus musculus) (aka olfactory receptor family 2 subfamily h member 1b)
B: hsd11b (homo sapiens) (aka hydroxysteroid 11-beta dehydrogenase 1)
C: or9m1b (mus musculus) (aka olfactory receptor family 9 subfamily m member 1b)
D: olfactory receptor family 11 subfamily h member 4b (... | [E] |
<Instruct>: Given the context 'XCE, a new member of the endothelin-converting enzyme and neutral endopeptidase family, is preferentially expressed in the CNS.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [xce]
<Options>: A: xct (homo sapiens) (aka solute carrier family 7 member 11)
B: xcxcra (xenopus laevis) (aka c-x-c chemokine receptor type a)
C: xce (mus musculus) (x chromosome inactivation center (mus musculus)) (aka x chromosome inactivation center)
D: xcenp-e (xenopus laevis) (centromere protein e s h... | [F] |
<Instruct>: Given the context 'The predicted amino-acid sequence of this enzyme, termed XCE, consists of 775 amino-acids with a single putative membrane-spanning region, an N-terminal cytoplasmic domain of 59 residues, and a large luminal domain that contains a characteristic zinc-binding motif.', select the correct bi... | <Mentions>: [xce]
<Options>: A: xce (homo sapiens) (x chromosome controlling element (homo sapiens)) (aka x chromosome controlling element)
B: xce (mus musculus) (x chromosome inactivation center (mus musculus)) (aka x chromosome inactivation center)
C: xcenp-e (xenopus laevis) (centromere protein e s homeolog (xenopus... | [F] |
<Instruct>: Given the context 'XCE mRNA was found to be predominantly expressed in the central nervous system, sympathetic ganglia and in uterine subepithelial cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [xce]
<Options>: A: xce (homo sapiens) (x chromosome inactivation center (homo sapiens)) (aka x chromosome inactivation center)
B: xce (mus musculus) (x chromosome inactivation center (mus musculus)) (aka x chromosome inactivation center)
C: xcel (xenopus tropicalis) (aka carboxyl ester lipase, gene 2)
D: x... | [F] |
<Instruct>: Given the context 'Herein we report the cDNA cloning of a human brain 25 kDa lysophospholipid-specific lysophospholipase (hLysoPLA).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lysophospholipid-specific lysophospholipase; hlysopla]
<Options>: A: lysophospholipase 1 (homo sapiens) (aka lysophospholipase 1)
B: hpo (homo sapiens) (aka growth factor, augmenter of liver regeneration)
C: lysophospholipase 2 (xenopus tropicalis) (aka lysophospholipase 2)
D: lysophospholipase 2 l homeolo... | [A; A] |
<Instruct>: Given the context 'Herein we report the cDNA cloning of a human brain 25 kDa lysophospholipid-specific lysophospholipase (hLysoPLA).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lysophospholipid-specific lysophospholipase; hlysopla]
<Options>: A: lpsa (homo sapiens) (aka oncogene liposarcoma (dna segment, single copy, expressed, probes)
B: lysophospholipase 1 (xenopus tropicalis) (aka lysophospholipase 1)
C: patatin like domain 7, lysophospholipase (homo sapiens) (aka patatin like... | [H; H] |
<Instruct>: Given the context 'Herein we report the cDNA cloning of a human brain 25 kDa lysophospholipid-specific lysophospholipase (hLysoPLA).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lysophospholipid-specific lysophospholipase; hlysopla]
<Options>: A: lysophospholipase-like 1 (xenopus tropicalis) (aka lysophospholipase-like 1)
B: hpo (homo sapiens) (aka growth factor, augmenter of liver regeneration)
C: spgyla (homo sapiens) (aka deleted in azoospermia like)
D: patatin like domain 7, l... | [I; I] |
<Instruct>: Given the context 'The hLysoPLA hydrolyzes lysophosphatidylcholine in both monomeric and micellar forms, and exhibits apparent cooperativity and surface dilution kinetics, but not interfacial activation.', select the correct biomedical concept for each mention using the provided options. Answer by listing t... | <Mentions>: [hlysopla]
<Options>: A: spgyla (homo sapiens) (aka deleted in azoospermia like)
B: splash (homo sapiens) (aka phospholipase a2 group iid)
C: spo (homo sapiens) (lactoperoxidase (homo sapiens)) (aka lactoperoxidase)
D: lpsa (homo sapiens) (aka oncogene liposarcoma (dna segment, single copy, expressed, probe... | [E] |
<Instruct>: Given the context 'Detailed kinetic analysis indicates that the hLysoPLA binds first to the micellar surface and then to the substrate presented on the surface.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [hlysopla]
<Options>: A: splash (homo sapiens) (aka phospholipase a2 group iid)
B: hpo (homo sapiens) (aka growth factor, augmenter of liver regeneration)
C: lysophospholipase 1 (homo sapiens) (aka lysophospholipase 1)
D: potocki-lupski syndrome (homo sapiens) (aka potocki-lupski syndrome)
E: spgyla (homo s... | [C] |
<Instruct>: Given the context 'The kinetic parameters associated with this surface dilution kinetic model are reported, and it is concluded that hLysoPLA has a single substrate binding site and a surface recognition site.', select the correct biomedical concept for each mention using the provided options. Answer by lis... | <Mentions>: [hlysopla]
<Options>: A: spo (homo sapiens) (lactoperoxidase (homo sapiens)) (aka lactoperoxidase)
B: lysophospholipase 1 (homo sapiens) (aka lysophospholipase 1)
C: spgyla (homo sapiens) (aka deleted in azoospermia like)
D: splash (homo sapiens) (aka phospholipase a2 group iid)
E: lysopld (homo sapiens) (a... | [B] |
<Instruct>: Given the context 'In contrast to many non-specific lipolytic enzymes that exhibit lysophospholipase activity, hLysoPLA hydrolyzes only lysophospholipids and has no other significant enzymatic activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [hlysopla]
<Options>: A: splash (homo sapiens) (aka phospholipase a2 group iid)
B: lysophospholipase 1 (homo sapiens) (aka lysophospholipase 1)
C: spo (homo sapiens) (lactoperoxidase (homo sapiens)) (aka lactoperoxidase)
D: plosl (homo sapiens) (aka transmembrane immune signaling adaptor tyrobp)
E: potocki-... | [B] |
<Instruct>: Given the context 'Of special interest, hLysoPLA does not act on plasmenylcholine.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hlysopla]
<Options>: A: plosl (homo sapiens) (aka transmembrane immune signaling adaptor tyrobp)
B: lysophospholipase 1 (homo sapiens) (aka lysophospholipase 1)
C: spgyla (homo sapiens) (aka deleted in azoospermia like)
D: spo (homo sapiens) (lactoperoxidase (homo sapiens)) (aka lactoperoxidase)
E: ospl (h... | [B] |
<Instruct>: Given the context 'Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [syt; brm]
<Options>: A: syt (xenopus laevis) (synaptotagmin 1 s homeolog (xenopus laevis)) (aka synaptotagmin 1 s homeolog)
B: brm (homo sapiens) (aka swi/snf related baf chromatin remodeling complex subunit atpase 2)
C: brm (mus musculus) (aka swi/snf related baf chromatin remodeling complex subunit atpas... | [K; B] |
<Instruct>: Given the context 'Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [syt; brm]
<Options>: A: syt1 (homo sapiens) (aka synaptotagmin 1)
B: synaptotagmin-1 (xenopus tropicalis) (aka synaptotagmin-1)
C: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster)) (aka synaptotagmin 1)
D: brm (homo sapiens) (aka swi/snf related baf chromatin remodeling complex subu... | [K; D] |
<Instruct>: Given the context 'The t(X;18)(p11.2;q11.2) chromosomal translocation commonly found in synovial sarcomas fuses the SYT gene on chromosome 18 to either of two similar genes, SSX1 or SSX2, on the X chromosome.', select the correct biomedical concept for each mention using the provided options. Answer by list... | <Mentions>: [syt; ssx1; ssx2]
<Options>: A: syt (xenopus laevis) (synaptotagmin 1 s homeolog (xenopus laevis)) (aka synaptotagmin 1 s homeolog)
B: syt-vii (homo sapiens) (aka synaptotagmin 7)
C: ssx2 (saccharomyces cerevisiae s288c) (aka rox3p)
D: srpx1 (xenopus laevis) (sushi repeat containing protein x-linked s homeo... | [P; E; I] |
<Instruct>: Given the context 'The t(X;18)(p11.2;q11.2) chromosomal translocation commonly found in synovial sarcomas fuses the SYT gene on chromosome 18 to either of two similar genes, SSX1 or SSX2, on the X chromosome.', select the correct biomedical concept for each mention using the provided options. Answer by list... | <Mentions>: [syt; ssx1; ssx2]
<Options>: A: ssx1 (saccharomyces cerevisiae s288c) (aka srb7p)
B: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster)) (aka synaptotagmin 1)
C: ssx family member 1 (homo sapiens) (aka ssx family member 1)
D: protein ssuh2 homolog (xenopus laevis) (aka protein ssuh2 ho... | [P; C; K] |
<Instruct>: Given the context 'The t(X;18)(p11.2;q11.2) chromosomal translocation commonly found in synovial sarcomas fuses the SYT gene on chromosome 18 to either of two similar genes, SSX1 or SSX2, on the X chromosome.', select the correct biomedical concept for each mention using the provided options. Answer by list... | <Mentions>: [syt; ssx1; ssx2]
<Options>: A: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster)) (aka synaptotagmin 1)
B: sox-2 (xenopus laevis) (sry-box 2 s homeolog (xenopus laevis)) (aka sry-box 2 s homeolog)
C: syt (xenopus tropicalis) (aka synaptotagmin 1)
D: ssx (homo sapiens) (ssx family mem... | [P; J; D] |
<Instruct>: Given the context 'The SYT protein appears to act as a transcriptional co-activator and the SSX proteins as co-repressors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [syt]
<Options>: A: synaptotagmin-1 (xenopus tropicalis) (aka synaptotagmin-1)
B: syt-vii (homo sapiens) (aka synaptotagmin 7)
C: syt1 (homo sapiens) (aka synaptotagmin 1)
D: synaptotagmin 1 (xenopus tropicalis) (aka synaptotagmin 1)
E: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster... | [F] |
<Instruct>: Given the context 'The SYT protein has a novel conserved 54 amino acid domain at the N-terminus of the protein (the SNH domain) which is found in proteins from a wide variety of species, and a C-terminal domain, rich in glutamine, proline, glycine and tyrosine (the QPGY domain), which contains the transcrip... | <Mentions>: [syt]
<Options>: A: synaptotagmin 1 (xenopus tropicalis) (aka synaptotagmin 1)
B: synaptoporin (xenopus tropicalis) (aka synaptoporin)
C: syt (xenopus laevis) (synaptotagmin 1 s homeolog (xenopus laevis)) (aka synaptotagmin 1 s homeolog)
D: syt1 (homo sapiens) (aka synaptotagmin 1)
E: syn (drosophila melano... | [F] |
<Instruct>: Given the context 'The C-terminal SSX domain present in SYT-SSX translocation protein contributes a transcriptional repressor domain to the protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [syt]
<Options>: A: syt7 (homo sapiens) (aka synaptotagmin 7)
B: syt1 (xenopus tropicalis) (aka synaptotagmin 1)
C: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster)) (aka synaptotagmin 1)
D: syt1 (homo sapiens) (aka synaptotagmin 1)
E: syt (xenopus laevis) (synaptotagmin 1 s homeolog... | [F] |
<Instruct>: Given the context 'We demonstrate that the human homologue of the SNF2/Brahama protein BRM co-localizes with SYT and SYT-SSX in nuclear speckles, and also interacts with SYT and SYT-SSX proteins in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [snf2; brahama; brm; syt]
<Options>: A: arabidopsis thaliana brahma (arabidopsis thaliana) (aka transcription regulatory protein snf2)
B: brm (drosophila melanogaster) (aka brahma)
C: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster)) (aka synaptotagmin 1)
D: syt (xenopus laevis) (syn... | [E; E; E; T] |
<Instruct>: Given the context 'We demonstrate that the human homologue of the SNF2/Brahama protein BRM co-localizes with SYT and SYT-SSX in nuclear speckles, and also interacts with SYT and SYT-SSX proteins in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [snf2; brahama; brm; syt]
<Options>: A: brm1 (mus musculus) (aka brachyury modifier 1)
B: snf2-beta (homo sapiens) (aka swi/snf related baf chromatin remodeling complex subunit atpase 4)
C: snf2l2 (homo sapiens) (aka swi/snf related baf chromatin remodeling complex subunit atpase 2)
D: brt (mus musculus) (a... | [C; C; C; T] |
<Instruct>: Given the context 'We demonstrate that the human homologue of the SNF2/Brahama protein BRM co-localizes with SYT and SYT-SSX in nuclear speckles, and also interacts with SYT and SYT-SSX proteins in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [snf2; brahama; brm; syt]
<Options>: A: brx1, biogenesis of ribosomes (mus musculus) (aka brx1, biogenesis of ribosomes)
B: syt7 (homo sapiens) (aka synaptotagmin 7)
C: brm (drosophila melanogaster) (aka brahma)
D: syt (xenopus laevis) (synaptotagmin 1 s homeolog (xenopus laevis)) (aka synaptotagmin 1 s hom... | [J; J; J; T] |
<Instruct>: Given the context 'We demonstrate that the human homologue of the SNF2/Brahama protein BRM co-localizes with SYT and SYT-SSX in nuclear speckles, and also interacts with SYT and SYT-SSX proteins in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [snf2; brahama; brm; syt]
<Options>: A: syt1 (homo sapiens) (aka synaptotagmin 1)
B: brp (mus musculus) (aka growth differentiation factor 5)
C: snf2h (homo sapiens) (aka snf2 related chromatin remodeling atpase 5)
D: smarcf2 (homo sapiens) (aka at-rich interaction domain 1b)
E: nedeba (homo sapiens) (aka a... | [H; H; H; T] |
<Instruct>: Given the context 'We demonstrate that the human homologue of the SNF2/Brahama protein BRM co-localizes with SYT and SYT-SSX in nuclear speckles, and also interacts with SYT and SYT-SSX proteins in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [syt]
<Options>: A: synaptotagmin 1 (xenopus tropicalis) (aka synaptotagmin 1)
B: syt (xenopus laevis) (synaptotagmin 1 s homeolog (xenopus laevis)) (aka synaptotagmin 1 s homeolog)
C: synaptotagmin-1 (xenopus tropicalis) (aka synaptotagmin-1)
D: syt1 (homo sapiens) (aka synaptotagmin 1)
E: synaptoporin (xe... | [F] |
<Instruct>: Given the context 'This interaction may provide an explanation of how the SYT protein activates gene transcription.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [syt]
<Options>: A: syn (drosophila melanogaster) (synaptotagmin 1 (drosophila melanogaster)) (aka synaptotagmin 1)
B: syt (xenopus tropicalis) (aka synaptotagmin 1)
C: synaptoporin (xenopus tropicalis) (aka synaptoporin)
D: syt (xenopus laevis) (synaptotagmin 1 s homeolog (xenopus laevis)) (aka synaptotagm... | [F] |
<Instruct>: Given the context 'Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [delta-isoforms of the multifunctional ca2+/calmodulin-dependent protein kinase]
<Options>: A: protein kinase c delta (drosophila melanogaster) (aka protein kinase c delta)
B: camk2d (homo sapiens) (aka calcium/calmodulin dependent protein kinase ii delta)
C: calcium/calmodulin-dependent protein kinase ii, ... | [B] |
<Instruct>: Given the context 'Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [delta-isoforms of the multifunctional ca2+/calmodulin-dependent protein kinase]
<Options>: A: protein kinase c delta (drosophila melanogaster) (aka protein kinase c delta)
B: calcium/calmodulin-dependent protein kinase ii, delta (mus musculus) (aka calcium/calmodulin-dependent protein kinase ii, delta)
C: ... | [E] |
<Instruct>: Given the context 'In this study, we investigated the spectrum of CaMKII isoforms delta2, delta3, delta4, delta8, and delta9 in human striated muscle tissue.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [camkii isoforms delta2, delta3, delta4, delta8, and delta9]
<Options>: A: calcium/calmodulin-dependent protein kinase ii, delta (mus musculus) (aka calcium/calmodulin-dependent protein kinase ii, delta)
B: cki-delta (homo sapiens) (aka casein kinase 1 delta)
C: calcium/calmodulin dependent protein kinase i... | [D] |
<Instruct>: Given the context 'relative to the expression of glyceraldehyde-3-phosphate dehydrogenase in diseased hearts (101. 6+/-11.0% versus 64.9+/-9.9% in the nonfailing group; P < 0.05, n=6).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options... | <Mentions>: [glyceraldehyde-3-phosphate dehydrogenase]
<Options>: A: glyceraldehyde 3 phosphate dehydrogenase 1 (drosophila melanogaster) (aka glyceraldehyde 3 phosphate dehydrogenase 1)
B: glyceraldehyde 3-phosphate dehydrogenase (glycine max) (aka glyceraldehyde 3-phosphate dehydrogenase)
C: gapdh (homo sapiens) (gly... | [C] |
<Instruct>: Given the context 'At the protein level, by using a subclass-specific antibody, we observed a similar increase of a delta-CaMKII-specific signal (7.2+/-1.0 versus 3.8+/-0.7 optical density units in the nonfailing group; P < 0.05, n=4 through 6).', select the correct biomedical concept for each mention using... | <Mentions>: [delta-camkii]
<Options>: A: camk2 (xenopus tropicalis) (calcium/calmodulin dependent protein kinase (cam kinase) ii delta (xenopus tropicalis)) (aka calcium/calmodulin dependent protein kinase (cam kinase) ii delta)
B: camk2d (homo sapiens) (aka calcium/calmodulin dependent protein kinase ii delta)
C: calc... | [B] |
<Instruct>: Given the context 'Our data characterize for the first time the delta-CaMKII isoform expression pattern in human hearts and demonstrate changes in this expression pattern in heart failure.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [delta-camkii]
<Options>: A: calcium/calmodulin dependent protein kinase ii delta (homo sapiens) (aka calcium/calmodulin dependent protein kinase ii delta)
B: calcium/calmodulin dependent protein kinase ii delta (gallus gallus) (aka calcium/calmodulin dependent protein kinase ii delta)
C: calcium/calmodulin... | [A] |
<Instruct>: Given the context 'Cloning and sequencing of the complete cDNA encoding the human insulin receptor related receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [insulin receptor related receptor]
<Options>: A: igf2r (homo sapiens) (aka insulin like growth factor 2 receptor)
B: insulin receptor related receptor (sus scrofa) (aka insulin receptor related receptor)
C: insulin receptor related receptor (homo sapiens) (aka insulin receptor related receptor)
D: insulin ... | [C] |
<Instruct>: Given the context 'The insulin receptor related receptor (IRR) is a heterotetrameric transmembrane receptor with intrinsic tyrosine kinase activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [insulin receptor related receptor; irr]
<Options>: A: ifngr1 (homo sapiens) (aka interferon gamma receptor 1)
B: ip10-r (homo sapiens) (aka c-x-c motif chemokine receptor 3)
C: insulin receptor related receptor (sus scrofa) (aka insulin receptor related receptor)
D: insulin receptor-related receptor (mus m... | [H; H] |
<Instruct>: Given the context 'The insulin receptor related receptor (IRR) is a heterotetrameric transmembrane receptor with intrinsic tyrosine kinase activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [insulin receptor related receptor; irr]
<Options>: A: ip10-r (homo sapiens) (aka c-x-c motif chemokine receptor 3)
B: insulin receptor related receptor (homo sapiens) (aka insulin receptor related receptor)
C: ifnr (homo sapiens) (aka interferon production regulator)
D: il1r3 (homo sapiens) (aka interleuki... | [B; B] |
<Instruct>: Given the context 'The IRR shares large homology with the insulin and the insulin-like growth factor-1 (IGF-I) receptor with regard to amino acid sequence and protein structure.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [irr]
<Options>: A: irr (homo sapiens) (aka insulin receptor related receptor)
B: ip10-r (homo sapiens) (aka c-x-c motif chemokine receptor 3)
C: ifngr (homo sapiens) (aka interferon gamma receptor 1)
D: il1r (homo sapiens) (aka interleukin 1 receptor type 1)
E: il1r3 (homo sapiens) (aka interleukin 1 recep... | [A] |
<Instruct>: Given the context 'The IRR shares large homology with the insulin and the insulin-like growth factor-1 (IGF-I) receptor with regard to amino acid sequence and protein structure.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [irr]
<Options>: A: ifngr (homo sapiens) (aka interferon gamma receptor 1)
B: il1r3 (homo sapiens) (aka interleukin 1 receptor accessory protein)
C: ip10-r (homo sapiens) (aka c-x-c motif chemokine receptor 3)
D: il1r (homo sapiens) (aka interleukin 1 receptor type 1)
E: None of the above. | [E] |
<Instruct>: Given the context 'So far, only a partial human sequence containing the complete 3' end has been reported, although the full-length human IRR cDNA had been used for transfection studies and functional analysis of the receptor.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [irr]
<Options>: A: insr (homo sapiens) (aka insulin receptor)
B: il1r (homo sapiens) (aka interleukin 1 receptor type 1)
C: il1r3 (homo sapiens) (aka interleukin 1 receptor accessory protein)
D: ip10-r (homo sapiens) (aka c-x-c motif chemokine receptor 3)
E: irr (homo sapiens) (aka insulin receptor related... | [E] |
<Instruct>: Given the context 'We have isolated a full-length human IRR cDNA and report on the 5' translated and untranslated region of the human IRR gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semi... | <Mentions>: [irr]
<Options>: A: insulin receptor related receptor (homo sapiens) (aka insulin receptor related receptor)
B: insr (homo sapiens) (aka insulin receptor)
C: il1r3 (homo sapiens) (aka interleukin 1 receptor accessory protein)
D: il1r (homo sapiens) (aka interleukin 1 receptor type 1)
E: ifnr (homo sapiens) ... | [A] |
<Instruct>: Given the context 'The full length IRR sequence contains 4150 bases and shares a high degree of homology with the guinea pig IRR cDNA sequence and rat IRR sequences that had been reported earlier on by others.', select the correct biomedical concept for each mention using the provided options. Answer by lis... | <Mentions>: [irr]
<Options>: A: ifnr (homo sapiens) (aka interferon production regulator)
B: insrr (homo sapiens) (aka insulin receptor related receptor)
C: ip10-r (homo sapiens) (aka c-x-c motif chemokine receptor 3)
D: il1r (homo sapiens) (aka interleukin 1 receptor type 1)
E: insr (homo sapiens) (aka insulin recepto... | [B] |
<Instruct>: Given the context 'Sequencing of the IRR cDNA revealed that the human IRR cDNA contains 341 bases corresponding to the IRR 5' end in addition to the bases that had been reported on before.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [irr]
<Options>: A: il1r (homo sapiens) (aka interleukin 1 receptor type 1)
B: ip10-r (homo sapiens) (aka c-x-c motif chemokine receptor 3)
C: il1r3 (homo sapiens) (aka interleukin 1 receptor accessory protein)
D: insulin receptor related receptor (homo sapiens) (aka insulin receptor related receptor)
E: if... | [D] |
<Instruct>: Given the context 'The full length cDNA for the human IRR can now be used for functional expression studies and to elucidate the nature of the ligand for this receptor type.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for e... | <Mentions>: [irr]
<Options>: A: ip10-r (homo sapiens) (aka c-x-c motif chemokine receptor 3)
B: insrr (homo sapiens) (aka insulin receptor related receptor)
C: insr (homo sapiens) (aka insulin receptor)
D: ifnr (homo sapiens) (aka interferon production regulator)
E: il1r (homo sapiens) (aka interleukin 1 receptor type ... | [B] |
<Instruct>: Given the context 'The deduced amino acids sequence shows an overall homology of 48% with the human renal NPT1 protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [npt1]
<Options>: A: slc-1 (homo sapiens) (aka melanin concentrating hormone receptor 1)
B: solute carrier family 11 member 1 (homo sapiens) (aka solute carrier family 11 member 1)
C: solute carrier family 1 member 1 (homo sapiens) (aka solute carrier family 1 member 1)
D: npt2 (homo sapiens) (aka solute ca... | [E] |
<Instruct>: Given the context 'Thus, this gene may code for intestinal type NPT or closely related proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [intestinal type npt]
<Options>: A: npt2c (homo sapiens) (aka solute carrier family 34 member 3)
B: npnt (homo sapiens) (aka nephronectin)
C: npat (homo sapiens) (aka nuclear protein, coactivator of histone transcription)
D: npt4 (homo sapiens) (aka solute carrier family 17 member 3)
E: npt2 (rattus norvegi... | [F] |
<Instruct>: Given the context 'Cutting edge: immature dendritic cells generated from monocytes in the presence of TGF-beta 1 express functional C-C chemokine receptor 6.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, se... | <Mentions>: [tgf-beta 1; c-c chemokine receptor 6]
<Options>: A: tgf-beta1 (homo sapiens) (aka transforming growth factor beta 1)
B: il1-beta (homo sapiens) (aka interleukin 1 beta)
C: c-x-c motif chemokine receptor 6 (homo sapiens) (aka c-x-c motif chemokine receptor 6)
D: interferon beta 1 (homo sapiens) (aka interfe... | [A; E] |
<Instruct>: Given the context 'Cutting edge: immature dendritic cells generated from monocytes in the presence of TGF-beta 1 express functional C-C chemokine receptor 6.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, se... | <Mentions>: [tgf-beta 1; c-c chemokine receptor 6]
<Options>: A: c-c motif chemokine receptor 6 (homo sapiens) (aka c-c motif chemokine receptor 6)
B: transforming growth factor beta 1 (bos taurus) (aka transforming growth factor beta 1)
C: cxcr6 (homo sapiens) (aka c-x-c motif chemokine receptor 6)
D: transforming gro... | [I; A] |
<Instruct>: Given the context 'Although CD34+ progenitor-derived immature dendritic cells (DCs) express CCR6, several recent studies reported that monocyte-derived immature DCs do not do so.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one ... | <Mentions>: [ccr6]
<Options>: A: c-x-c motif chemokine receptor 6 (homo sapiens) (aka c-x-c motif chemokine receptor 6)
B: ccr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
C: ccr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
D: None of the above. | [C] |
<Instruct>: Given the context 'We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha).', select the correct biomedical concept for each mention using th... | <Mentions>: [gm-csf; il-4; tgf-beta 1; liver and activation-regulated chemokine]
<Options>: A: il4 (homo sapiens) (aka interleukin 4)
B: ccl16 (homo sapiens) (aka c-c motif chemokine ligand 16)
C: transforming growth factor beta receptor 1 (homo sapiens) (aka transforming growth factor beta receptor 1)
D: il1-beta (hom... | [G; A; T; U] |
<Instruct>: Given the context 'We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha).', select the correct biomedical concept for each mention using th... | <Mentions>: [gm-csf; il-4; tgf-beta 1; liver and activation-regulated chemokine]
<Options>: A: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
B: c-c motif chemokine ligand 3 (homo sapiens) (aka c-c motif chemokine ligand 3)
C: colony stimulating factor 3 (homo sapiens) (aka colony stimulating factor 3)
D:... | [Q; D; M; U] |
<Instruct>: Given the context 'We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha).', select the correct biomedical concept for each mention using th... | <Mentions>: [gm-csf; il-4; tgf-beta 1; liver and activation-regulated chemokine]
<Options>: A: interferon beta 1 (homo sapiens) (aka interferon beta 1)
B: colony stimulating factor 2 (homo sapiens) (aka colony stimulating factor 2)
C: interleukin 5 (homo sapiens) (aka interleukin 5)
D: colony stimulating factor 1 (homo... | [B; T; N; T] |
<Instruct>: Given the context 'We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha).', select the correct biomedical concept for each mention using th... | <Mentions>: [gm-csf; il-4; tgf-beta 1; liver and activation-regulated chemokine]
<Options>: A: interferon beta 1 (homo sapiens) (aka interferon beta 1)
B: il-4 (bos taurus) (aka interleukin 4)
C: gm-csf (mus musculus) (aka colony stimulating factor 2 (granulocyte-macrophage))
D: interleukin 5 (homo sapiens) (aka interl... | [H; T; F; U] |
<Instruct>: Given the context 'We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha).', select the correct biomedical concept for each mention using th... | <Mentions>: [gm-csf; il-4; tgf-beta 1; liver and activation-regulated chemokine]
<Options>: A: csf1 (homo sapiens) (aka colony stimulating factor 1)
B: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
C: gm-csf (mus musculus) (aka colony stimulating factor 2 (granulocyte-macrophage))
D: transforming growth facto... | [G; F; J; U] |
<Instruct>: Given the context 'We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha).', select the correct biomedical concept for each mention using th... | <Mentions>: [larc; macrophage inflammatory protein-3 alpha]
<Options>: A: c-x-c motif chemokine ligand 3 (homo sapiens) (aka c-x-c motif chemokine ligand 3)
B: lncsrlr (homo sapiens) (aka lncrna sorafenib resistance in renal cell carcinoma associated)
C: mcp-3 (homo sapiens) (aka c-c motif chemokine ligand 7)
D: ccl3 (... | [E; E] |
<Instruct>: Given the context 'We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha).', select the correct biomedical concept for each mention using th... | <Mentions>: [larc; macrophage inflammatory protein-3 alpha]
<Options>: A: ccl3 (homo sapiens) (aka c-c motif chemokine ligand 3)
B: mip3 (homo sapiens) (aka c-c motif chemokine ligand 23)
C: mcp-3 (homo sapiens) (aka c-c motif chemokine ligand 7)
D: lncarsr (homo sapiens) (aka lncrna regulator of akt signaling associat... | [I; I] |
<Instruct>: Given the context 'We observed that DCs generated from monocytes in the presence of GM-CSF, IL-4, and TGF-beta 1 consistently responded to liver and activation-regulated chemokine (LARC, also known as macrophage inflammatory protein-3 alpha).', select the correct biomedical concept for each mention using th... | <Mentions>: [larc; macrophage inflammatory protein-3 alpha]
<Options>: A: c-c motif chemokine ligand 3 (homo sapiens) (aka c-c motif chemokine ligand 3)
B: larc (mus musculus) (aka c-c motif chemokine ligand 20)
C: lar1 (homo sapiens) (aka la ribonucleoprotein 1, translational regulator)
D: c-x-c motif chemokine ligand... | [I; I] |
<Instruct>: Given the context 'These immature DCs expressed one class of high-affinity binding sites for LARC, and expressed both CCR6 mRNA and protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicol... | <Mentions>: [larc; ccr6]
<Options>: A: c-c ckr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
B: larc (mus musculus) (aka c-c motif chemokine ligand 20)
C: cxcr6 (homo sapiens) (aka c-x-c motif chemokine receptor 6)
D: ccr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
E: lnc-rhl (homo sapiens) (aka lncrn... | [H; A] |
<Instruct>: Given the context 'These immature DCs expressed one class of high-affinity binding sites for LARC, and expressed both CCR6 mRNA and protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicol... | <Mentions>: [larc; ccr6]
<Options>: A: larc (mus musculus) (aka c-c motif chemokine ligand 20)
B: larc (homo sapiens) (aka c-c motif chemokine ligand 20)
C: cc-ckr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
D: larc (xenopus tropicalis) (aka c-c motif chemokine ligand 20)
E: lncsrlr (homo sapiens) (aka lncrna... | [B; H] |
<Instruct>: Given the context 'Therefore, LARC-CCR6 interaction presumably also contributes to the regulation of trafficking of monocyte-derived DCs, and utilization of TGF-beta can potentially provide a ready source of CCR6+ monocyte-derived DCs for therapeutic purposes.', select the correct biomedical concept for eac... | <Mentions>: [larc; ccr6]
<Options>: A: cc-ckr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
B: larc (homo sapiens) (aka c-c motif chemokine ligand 20)
C: lar (homo sapiens) (aka protein tyrosine phosphatase receptor type f)
D: cc-ckr-6 (homo sapiens) (aka c-c motif chemokine receptor 6)
E: cxcr6 (homo sapiens) ... | [B; D] |
<Instruct>: Given the context 'Therefore, LARC-CCR6 interaction presumably also contributes to the regulation of trafficking of monocyte-derived DCs, and utilization of TGF-beta can potentially provide a ready source of CCR6+ monocyte-derived DCs for therapeutic purposes.', select the correct biomedical concept for eac... | <Mentions>: [larc; ccr6]
<Options>: A: lar (homo sapiens) (aka protein tyrosine phosphatase receptor type f)
B: lar1 (homo sapiens) (aka la ribonucleoprotein 1, translational regulator)
C: cc-ckr-8 (homo sapiens) (aka c-c motif chemokine receptor 8)
D: lncarsr (homo sapiens) (aka lncrna regulator of akt signaling assoc... | [G; H] |
<Instruct>: Given the context 'Therefore, LARC-CCR6 interaction presumably also contributes to the regulation of trafficking of monocyte-derived DCs, and utilization of TGF-beta can potentially provide a ready source of CCR6+ monocyte-derived DCs for therapeutic purposes.', select the correct biomedical concept for eac... | <Mentions>: [larc; ccr6]
<Options>: A: larc (xenopus tropicalis) (aka c-c motif chemokine ligand 20)
B: lncarsr (homo sapiens) (aka lncrna regulator of akt signaling associated with hcc and rcc)
C: lar1 (homo sapiens) (aka la ribonucleoprotein 1, translational regulator)
D: lar (homo sapiens) (aka protein tyrosine phos... | [H; E] |
<Instruct>: Given the context 'Identification and characterization of PKNbeta, a novel isoform of protein kinase PKN: expression and arachidonic acid dependency are different from those of PKNalpha.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opti... | <Mentions>: [pknbeta; pknalpha]
<Options>: A: pkgb (homo sapiens) (aka junction plakoglobin)
B: pkn2 (homo sapiens) (aka protein kinase n2)
C: protein kinase c, beta (rattus norvegicus) (aka protein kinase c, beta)
D: prkn (homo sapiens) (aka parkin rbr e3 ubiquitin protein ligase)
E: prkr (homo sapiens) (aka eukaryoti... | [K; J] |
<Instruct>: Given the context 'Identification and characterization of PKNbeta, a novel isoform of protein kinase PKN: expression and arachidonic acid dependency are different from those of PKNalpha.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opti... | <Mentions>: [pknbeta; pknalpha]
<Options>: A: pkn2 (homo sapiens) (aka protein kinase n2)
B: cdc42 binding protein kinase beta (bos taurus) (aka cdc42 binding protein kinase beta)
C: pkn-alpha (homo sapiens) (aka protein kinase n1)
D: pkn-alpha (xenopus laevis) (aka protein kinase n1 l homeolog)
E: pku-alpha (homo sapi... | [J; C] |
<Instruct>: Given the context 'The cDNA clone encoding a novel isoform of protein kinase PKN, termed PKNbeta, was isolated from a HeLa cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pknbeta]
<Options>: A: protein kinase c beta (bos taurus) (aka protein kinase c beta)
B: protein kinase c beta (homo sapiens) (aka protein kinase c beta)
C: pkn-alpha (homo sapiens) (aka protein kinase n1)
D: pkbbeta (homo sapiens) (aka akt serine/threonine kinase 2)
E: cdc42 binding protein kinase beta (b... | [F] |
<Instruct>: Given the context 'PKNbeta had high sequence homology with PKNalpha, originally isolated PKN, especially in the repeats of charged amino acid-rich region with leucine-zipper like sequences (CZ region/HR1), in the carboxyl-terminal catalytic domain, and in approximately 130 amino acid stretch (D region/HR2),... | <Mentions>: [pknbeta; pknalpha]
<Options>: A: pkbbeta (homo sapiens) (aka akt serine/threonine kinase 2)
B: pkn2 (homo sapiens) (aka protein kinase n2)
C: protein kinase c beta (bos taurus) (aka protein kinase c beta)
D: cdc42 binding protein kinase beta (bos taurus) (aka cdc42 binding protein kinase beta)
E: pkn (homo... | [K; E] |
<Instruct>: Given the context 'PKNbeta had high sequence homology with PKNalpha, originally isolated PKN, especially in the repeats of charged amino acid-rich region with leucine-zipper like sequences (CZ region/HR1), in the carboxyl-terminal catalytic domain, and in approximately 130 amino acid stretch (D region/HR2),... | <Mentions>: [pknbeta; pknalpha]
<Options>: A: pkn-alpha (homo sapiens) (aka protein kinase n1)
B: pkn-alpha (xenopus tropicalis) (aka protein kinase n1)
C: pku-alpha (homo sapiens) (aka tousled like kinase 2)
D: pkgb (homo sapiens) (aka junction plakoglobin)
E: pkn-alpha (xenopus laevis) (aka protein kinase n1 l homeol... | [J; A] |
<Instruct>: Given the context 'However, the amino acid sequence of PKNbeta differed from that of PKNalpha in the region immediately amino-terminal to the catalytic domain, which contained two distinct proline-rich sequences consistent with the class II consensus sequence, PXXPXR, for binding to SH3 domain.', select the... | <Mentions>: [pknbeta; pknalpha]
<Options>: A: pkgb (homo sapiens) (aka junction plakoglobin)
B: protein kinase c beta (bos taurus) (aka protein kinase c beta)
C: pku-alpha (homo sapiens) (aka tousled like kinase 2)
D: prkn (homo sapiens) (aka parkin rbr e3 ubiquitin protein ligase)
E: pkn-alpha (homo sapiens) (aka prot... | [K; G] |
<Instruct>: Given the context 'However, the amino acid sequence of PKNbeta differed from that of PKNalpha in the region immediately amino-terminal to the catalytic domain, which contained two distinct proline-rich sequences consistent with the class II consensus sequence, PXXPXR, for binding to SH3 domain.', select the... | <Mentions>: [pknbeta; pknalpha]
<Options>: A: pku-alpha (homo sapiens) (aka tousled like kinase 2)
B: pkn-alpha (xenopus laevis) (aka protein kinase n1 l homeolog)
C: pkn-alpha (homo sapiens) (aka protein kinase n1)
D: cdc42 binding protein kinase beta (bos taurus) (aka cdc42 binding protein kinase beta)
E: protein kin... | [K; I] |
<Instruct>: Given the context 'Distribution of PKNbeta differed from that of PKNalpha in the following two respects: (1) Northern blotting indicated that PKNbeta mRNA could not be detected in human adult tissues, but was expressed abundantly in human cancer cell lines; (2) immunochemical analysis indicated that PKNbeta... | <Mentions>: [pknbeta; pknalpha]
<Options>: A: pkn (homo sapiens) (aka protein kinase n1)
B: prkn (homo sapiens) (aka parkin rbr e3 ubiquitin protein ligase)
C: pkbbeta (homo sapiens) (aka akt serine/threonine kinase 2)
D: pkn-alpha (xenopus tropicalis) (aka protein kinase n1)
E: pkgb (homo sapiens) (aka junction plakog... | [K; A] |
<Instruct>: Given the context 'Distribution of PKNbeta differed from that of PKNalpha in the following two respects: (1) Northern blotting indicated that PKNbeta mRNA could not be detected in human adult tissues, but was expressed abundantly in human cancer cell lines; (2) immunochemical analysis indicated that PKNbeta... | <Mentions>: [pknbeta; pknalpha]
<Options>: A: pkgb (homo sapiens) (aka junction plakoglobin)
B: protein kinase c beta (bos taurus) (aka protein kinase c beta)
C: protein kinase c, beta (rattus norvegicus) (aka protein kinase c, beta)
D: pkn-alpha (xenopus tropicalis) (aka protein kinase n1)
E: prkn (homo sapiens) (aka ... | [J; H] |
<Instruct>: Given the context 'Recombinant PKNbeta expressed in COS7 cells displayed autophosphorylation and peptide kinase activity, but was found to be significantly less responsive to arachidonic acid than PKNalpha.', select the correct biomedical concept for each mention using the provided options. Answer by listin... | <Mentions>: [pknbeta; pknalpha]
<Options>: A: pkn2 (homo sapiens) (aka protein kinase n2)
B: protein kinase c beta (bos taurus) (aka protein kinase c beta)
C: pkc-beta (homo sapiens) (aka protein kinase c beta)
D: pku-alpha (homo sapiens) (aka tousled like kinase 2)
E: pkn-alpha (xenopus tropicalis) (aka protein kinase... | [K; F] |
<Instruct>: Given the context 'Recombinant PKNbeta expressed in COS7 cells displayed autophosphorylation and peptide kinase activity, but was found to be significantly less responsive to arachidonic acid than PKNalpha.', select the correct biomedical concept for each mention using the provided options. Answer by listin... | <Mentions>: [pknbeta; pknalpha]
<Options>: A: cdc42 binding protein kinase beta (bos taurus) (aka cdc42 binding protein kinase beta)
B: pkn-alpha (xenopus tropicalis) (aka protein kinase n1)
C: pku-alpha (homo sapiens) (aka tousled like kinase 2)
D: pkn (drosophila melanogaster) (protein kinase n (drosophila melanogast... | [K; J] |
<Instruct>: Given the context 'Coats' disease of the retina (unilateral retinal telangiectasis) caused by somatic mutation in the NDP gene: a role for norrin in retinal angiogenesis.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [ndp; norrin]
<Options>: A: naked cuticle homolog 1 (xenopus tropicalis) (aka naked cuticle homolog 1)
B: nrn (rattus norvegicus) (aka neuritin 1)
C: norp (rattus norvegicus) (aka nucleolin, pseudogene 1)
D: nynrin (rattus norvegicus) (aka nyn domain and retroviral integrase containing)
E: ndnf (homo sapien... | [H; H] |
<Instruct>: Given the context 'Coats' disease of the retina (unilateral retinal telangiectasis) caused by somatic mutation in the NDP gene: a role for norrin in retinal angiogenesis.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [ndp; norrin]
<Options>: A: norp (rattus norvegicus) (aka nucleolin, pseudogene 1)
B: ndn (homo sapiens) (aka necdin, mage family member)
C: norrin cystine knot growth factor ndp (homo sapiens) (aka norrin cystine knot growth factor ndp)
D: nrn (rattus norvegicus) (aka neuritin 1)
E: ndnf (homo sapiens) (ak... | [C; C] |
<Instruct>: Given the context 'Both carried a missense mutation within the NDP gene on chromosome Xp11.2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ndp]
<Options>: A: ndp (xenopus tropicalis) (aka norrin cystine knot growth factor ndp)
B: ndc1 transmembrane nucleoporin (homo sapiens) (aka ndc1 transmembrane nucleoporin)
C: ndpkd (homo sapiens) (aka nme/nm23 nucleoside diphosphate kinase 4)
D: ndp (homo sapiens) (aka norrin cystine knot growth factor n... | [D] |
<Instruct>: Given the context 'Subsequently analysis of the retinas of nine enucleated eyes from males with Coats' disease demonstrated in one a somatic mutation in the NDP gene which was not present within non-retinal tissue.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [ndp]
<Options>: A: ndpkd (homo sapiens) (aka nme/nm23 nucleoside diphosphate kinase 4)
B: ndc1 transmembrane nucleoporin (homo sapiens) (aka ndc1 transmembrane nucleoporin)
C: norrin cystine knot growth factor ndp (homo sapiens) (aka norrin cystine knot growth factor ndp)
D: ndn (homo sapiens) (aka necdin,... | [C] |
<Instruct>: Given the context 'We suggest that Coats' telangiectasis is secondary to somatic mutation in the NDP gene which results in a deficiency of norrin (the protein product of the NDP gene) within the developing retina.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [ndp; norrin]
<Options>: A: nrn (rattus norvegicus) (aka neuritin 1)
B: ndp (homo sapiens) (aka norrin cystine knot growth factor ndp)
C: connectin (rattus norvegicus) (aka titin)
D: nor-2 (rattus norvegicus) (aka nuclear receptor subfamily 4, group a, member 3)
E: ndp (xenopus tropicalis) (aka norrin cysti... | [B; B] |
<Instruct>: Given the context 'We suggest that Coats' telangiectasis is secondary to somatic mutation in the NDP gene which results in a deficiency of norrin (the protein product of the NDP gene) within the developing retina.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [ndp; norrin]
<Options>: A: connectin (rattus norvegicus) (aka titin)
B: naked cuticle homolog 1 (xenopus tropicalis) (aka naked cuticle homolog 1)
C: nor-2 (rattus norvegicus) (aka nuclear receptor subfamily 4, group a, member 3)
D: norrin cystine knot growth factor ndp (homo sapiens) (aka norrin cystine k... | [D; D] |
<Instruct>: Given the context 'A common polymorphic allele of the human luteinizing hormone beta-subunit gene: additional mutations and differential function of the promoter sequence.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [luteinizing hormone beta-subunit]
<Options>: A: lutropin subunit beta (bos taurus) (aka lutropin subunit beta)
B: follicle stimulating hormone subunit beta (homo sapiens) (aka follicle stimulating hormone subunit beta)
C: luteinizing hormone subunit beta (homo sapiens) (aka luteinizing hormone subunit beta... | [C] |
<Instruct>: Given the context 'A common genetic variant (V) of the human luteinizing hormone (LH) beta-subunit gene was recently discovered.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [luteinizing hormone (lh) beta-subunit]
<Options>: A: luteinizing hormone subunit beta (sus scrofa) (aka luteinizing hormone subunit beta)
B: thyroid stimulating hormone subunit beta (homo sapiens) (aka thyroid stimulating hormone subunit beta)
C: lsh-beta (homo sapiens) (aka luteinizing hormone subunit bet... | [C] |
<Instruct>: Given the context 'The V-LH molecules have higher bioactivity in vitro, but shorter half-life in circulation, which apparently is related to the alterations of LH function observed in individuals homo- and heterozygous for the V-LHbeta allele.', select the correct biomedical concept for each mention using t... | <Mentions>: [lhbeta]
<Options>: A: luteinizing hormone subunit beta (homo sapiens) (aka luteinizing hormone subunit beta)
B: luteinizing hormone subunit beta (bos taurus) (aka luteinizing hormone subunit beta)
C: luteinizing hormone subunit beta (oryctolagus cuniculus) (aka luteinizing hormone subunit beta)
D: lutropin... | [A] |
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