instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'We have now studied whether additional mutations in the V-LHbeta promoter sequence could contribute to the altered physiology of the LH variant molecules.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for e... | <Mentions>: [lhbeta]
<Options>: A: luteinizing hormone subunit beta (sus scrofa) (aka luteinizing hormone subunit beta)
B: lutropin subunit beta-like (xenopus laevis) (aka lutropin subunit beta-like)
C: luteinizing hormone subunit beta (oryctolagus cuniculus) (aka luteinizing hormone subunit beta)
D: luteinizing hormon... | [E] |
<Instruct>: Given the context 'The 661 bp 5'-flanking region of the V-LHbeta gene, retrieved from human genomic DNA by PCR, contained eight single-nucleotide changes, as compared with the wild-type (wt) LHbeta promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listi... | <Mentions>: [lhbeta]
<Options>: A: lutropin subunit beta (bos taurus) (aka lutropin subunit beta)
B: lhb (homo sapiens) (luteinizing hormone subunit beta (homo sapiens)) (aka luteinizing hormone subunit beta)
C: luteinizing hormone subunit beta (oryctolagus cuniculus) (aka luteinizing hormone subunit beta)
D: lutropin ... | [B] |
<Instruct>: Given the context 'Reporter constructs with various lengths of the wt- and V-LH promoter sequences, driving the firefly luciferase reporter gene, were transfected into an immortalized mouse pituitary cell line, LbetaT(2), known to express the endogenous LHbeta gene, and into a non-endocrine human embryonic ... | <Mentions>: [lhbeta]
<Options>: A: lutropin subunit beta-like (xenopus laevis) (aka lutropin subunit beta-like)
B: luteinizing hormone subunit beta (sus scrofa) (aka luteinizing hormone subunit beta)
C: luteinizing hormone subunit beta (bos taurus) (aka luteinizing hormone subunit beta)
D: luteinizing hormone subunit b... | [E] |
<Instruct>: Given the context 'Basal expression levels of the V-LHbeta promoter constructs were on average 36% higher in LbetaT(2)cells ( P < 0.001; n = 29), and 40% higher in HEK 293 cells ( P < 0.001; n = 16), as compared with the respective wt sequences.', select the correct biomedical concept for each mention using... | <Mentions>: [lhbeta]
<Options>: A: luteinizing hormone subunit beta (sus scrofa) (aka luteinizing hormone subunit beta)
B: luteinizing hormone subunit beta (bos taurus) (aka luteinizing hormone subunit beta)
C: luteinizing hormone subunit beta (xenopus tropicalis) (aka luteinizing hormone subunit beta)
D: luteinizing h... | [E] |
<Instruct>: Given the context 'Numerous qualitative and quantitative differences were found between the two cell lines in responses of the two promoter sequences to stimulation with 12- O -tetradecanoylphorbol-13-acetate, forskolin, 8-bromo-cAMP, progesterone and gonado- tropin-releasing hormone.', select the correct b... | <Mentions>: [gonado- tropin-releasing hormone]
<Options>: A: hypocretin (orexin) neuropeptide precursor (xenopus tropicalis) (aka hypocretin (orexin) neuropeptide precursor)
B: growth hormone releasing hormone (homo sapiens) (aka growth hormone releasing hormone)
C: lhrh (xenopus tropicalis) (aka gonadotropin releasing... | [D] |
<Instruct>: Given the context 'In conclusion, the V-LHbeta promoter has higher basal activity, and differs in response to hormonal stimulation, as compared with the wt-LHbeta promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [lhbeta]
<Options>: A: lutropin subunit beta-like (xenopus laevis) (aka lutropin subunit beta-like)
B: lsh-beta (homo sapiens) (aka luteinizing hormone subunit beta)
C: luteinizing hormone subunit beta (xenopus tropicalis) (aka luteinizing hormone subunit beta)
D: luteinizing hormone subunit beta (oryctolag... | [B] |
<Instruct>: Given the context 'In conclusion, the V-LHbeta promoter has higher basal activity, and differs in response to hormonal stimulation, as compared with the wt-LHbeta promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [lhbeta]
<Options>: A: luteinizing hormone subunit beta (oryctolagus cuniculus) (aka luteinizing hormone subunit beta)
B: luteinizing hormone subunit beta (bos taurus) (aka luteinizing hormone subunit beta)
C: luteinizing hormone subunit beta (xenopus tropicalis) (aka luteinizing hormone subunit beta)
D: lu... | [E] |
<Instruct>: Given the context 'The altered promoter function of the V-LHbeta gene provides evidence for differences in regulation of the wt- and V-LHbeta genes, which may contribute to the differences observed in pituitary-gonadal function between carriers of the two LHbeta alleles.', select the correct biomedical conc... | <Mentions>: [lhbeta]
<Options>: A: luteinizing hormone subunit beta (sus scrofa) (aka luteinizing hormone subunit beta)
B: lhb (homo sapiens) (luteinizing hormone subunit beta (homo sapiens)) (aka luteinizing hormone subunit beta)
C: lutropin subunit beta (bos taurus) (aka lutropin subunit beta)
D: luteinizing hormone ... | [B] |
<Instruct>: Given the context 'The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hydroxypyruvate reductase; grhpr]
<Options>: A: grhpr (xenopus tropicalis) (glyoxylate reductase/hydroxypyruvate reductase, gene 1 (xenopus tropicalis)) (aka glyoxylate reductase/hydroxypyruvate reductase, gene 1)
B: hydroxypyruvate reductase 3 (arabidopsis thaliana) (aka d-isomer specific 2-hydroxyacid de... | [D; D] |
<Instruct>: Given the context 'The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hydroxypyruvate reductase; grhpr]
<Options>: A: grpr (homo sapiens) (aka gastrin releasing peptide receptor)
B: grhpr (xenopus tropicalis) (glyoxylate reductase/hydroxypyruvate reductase, gene 1 (xenopus tropicalis)) (aka glyoxylate reductase/hydroxypyruvate reductase, gene 1)
C: glyoxylate and hydroxypyru... | [E; E] |
<Instruct>: Given the context 'We identified a glyoxylate reductase/hydroxypyruvate reductase (GRHPR) cDNA clone from a human liver expressed sequence tag (EST) library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [glyoxylate reductase; hydroxypyruvate reductase; grhpr]
<Options>: A: reductase (glycine max) (aka chalcone reductase chr1)
B: hydroxypyruvate reductase (arabidopsis thaliana) (aka hydroxypyruvate reductase)
C: glyoxylate reductase 1 homolog (bos taurus) (aka glyoxylate reductase 1 homolog)
D: glyoxylate a... | [D; D; D] |
<Instruct>: Given the context 'We identified a glyoxylate reductase/hydroxypyruvate reductase (GRHPR) cDNA clone from a human liver expressed sequence tag (EST) library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [glyoxylate reductase; hydroxypyruvate reductase; grhpr]
<Options>: A: glyoxylate reductase 1 homolog (xenopus tropicalis) (aka glyoxylate reductase 1 homolog)
B: glyoxylate reductase 1 homolog (bos taurus) (aka glyoxylate reductase 1 homolog)
C: ghrhr (homo sapiens) (aka growth hormone releasing hormone re... | [L; L; L] |
<Instruct>: Given the context 'We identified a glyoxylate reductase/hydroxypyruvate reductase (GRHPR) cDNA clone from a human liver expressed sequence tag (EST) library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [glyoxylate reductase; hydroxypyruvate reductase; grhpr]
<Options>: A: hydroxypyruvate reductase (arabidopsis thaliana) (aka hydroxypyruvate reductase)
B: grr1 (glycine max) (aka putative ein3-binding f-box protein)
C: glyoxylate reductase 1 homolog (bos taurus) (aka glyoxylate reductase 1 homolog)
D: glyox... | [D; D; D] |
<Instruct>: Given the context 'Transient transfection of the cDNA clone into COS cells verified that it encoded an enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [glyoxylate reductase]
<Options>: A: glyoxylate reductase 1 homolog (xenopus tropicalis) (aka glyoxylate reductase 1 homolog)
B: reductase (glycine max) (aka chalcone reductase chr1)
C: glyoxylate reductase 1 homolog (sus scrofa) (aka glyoxylate reductase 1 homolog)
D: glyoxylate/succinic semialdehyde reduc... | [E] |
<Instruct>: Given the context 'The genomic structure of the human GRHPR gene was determined and contains nine exons and eight introns and spans approximately 9 kb pericentromeric on chromosome 9.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options,... | <Mentions>: [grhpr]
<Options>: A: grr1 (glycine max) (aka putative ein3-binding f-box protein)
B: gr (homo sapiens) (aka nuclear receptor subfamily 3 group c member 1)
C: grpr (homo sapiens) (aka gastrin releasing peptide receptor)
D: grhpr (homo sapiens) (aka glyoxylate and hydroxypyruvate reductase)
E: growth hormone... | [D] |
<Instruct>: Given the context 'Four PH2 patients representing two pairs of siblings from two unrelated families were analyzed for mutations in GRHPR by single strand conformation polymorphism analysis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [grhpr]
<Options>: A: grhpr (homo sapiens) (aka glyoxylate and hydroxypyruvate reductase)
B: grr1 (glycine max) (aka putative ein3-binding f-box protein)
C: gr (homo sapiens) (aka nuclear receptor subfamily 3 group c member 1)
D: prolactin releasing hormone receptor (homo sapiens) (aka prolactin releasing h... | [A] |
<Instruct>: Given the context 'The cDNA that we have identified represents the first characterization of an animal GRHPR sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [grhpr]
<Options>: A: grhpr (homo sapiens) (aka glyoxylate and hydroxypyruvate reductase)
B: growth hormone releasing hormone receptor (homo sapiens) (aka growth hormone releasing hormone receptor)
C: grpr (homo sapiens) (aka gastrin releasing peptide receptor)
D: grhr (homo sapiens) (aka gonadotropin relea... | [A] |
<Instruct>: Given the context 'Ectodysplasin is a collagenous trimeric type II membrane protein with a tumor necrosis factor-like domain and co-localizes with cytoskeletal structures at lateral and apical surfaces of cells.
', select the correct biomedical concept for each mention using the provided options. Answer by ... | <Mentions>: [ectodysplasin]
<Options>: A: ed3 (homo sapiens) (ectodysplasin a receptor (homo sapiens)) (aka ectodysplasin a receptor)
B: ectodysplasin a (danio rerio) (aka ectodysplasin a)
C: ectd1 (homo sapiens) (ectodysplasin a (homo sapiens)) (aka ectodysplasin a)
D: ectodysplasin a receptor (xenopus tropicalis) (ak... | [C] |
<Instruct>: Given the context 'Anhidrotic ectodermal dysplasia (EDA) is a human genetic disorder of impaired ectodermal appendage development.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ectodermal dysplasia; eda]
<Options>: A: ectrodactyly, ectodermal dysplasia and cleft lip/palate syndrome 1 (homo sapiens) (aka ectrodactyly, ectodermal dysplasia and cleft lip/palate syndrome 1)
B: eda1 (arabidopsis thaliana) (aka f-box associated ubiquitination effector family protein)
C: ectodermal dysp... | [I; I] |
<Instruct>: Given the context 'Anhidrotic ectodermal dysplasia (EDA) is a human genetic disorder of impaired ectodermal appendage development.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ectodermal dysplasia; eda]
<Options>: A: eda1 (xenopus laevis) (ectodysplasin a s homeolog (xenopus laevis)) (aka ectodysplasin a s homeolog)
B: otodental dysplasia chromosome deletion syndrome (homo sapiens) (aka otodental dysplasia chromosome deletion syndrome)
C: eed (homo sapiens) (aka embryonic ectode... | [I; I] |
<Instruct>: Given the context 'The EDA gene encodes isoforms of a novel transmembrane protein, ectodysplasin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eda; ectodysplasin]
<Options>: A: edd (arabidopsis thaliana) (aka glycine-trna ligase)
B: ectd1 (homo sapiens) (ectodysplasin a (homo sapiens)) (aka ectodysplasin a)
C: eda1 (xenopus laevis) (ectodysplasin a s homeolog (xenopus laevis)) (aka ectodysplasin a s homeolog)
D: ectodysplasin a (danio rerio) (aka... | [B; B] |
<Instruct>: Given the context 'The EDA gene encodes isoforms of a novel transmembrane protein, ectodysplasin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eda; ectodysplasin]
<Options>: A: ectodysplasin a receptor (xenopus tropicalis) (aka ectodysplasin a receptor)
B: eda1 (arabidopsis thaliana) (aka f-box associated ubiquitination effector family protein)
C: ectodysplasin a receptor (homo sapiens) (aka ectodysplasin a receptor)
D: ectodysplasin a (bos tauru... | [E; E] |
<Instruct>: Given the context 'In order to understand better the function of the ectodysplasin protein molecule and its domains, we have studied the processing and localization of wild-type and mutated isoforms in transfected human fetal kidney 293 and monkey kidney COS-1 cells.', select the correct biomedical concept ... | <Mentions>: [ectodysplasin]
<Options>: A: ed3 (homo sapiens) (ectodysplasin a receptor (homo sapiens)) (aka ectodysplasin a receptor)
B: ectodysplasin a (danio rerio) (aka ectodysplasin a)
C: ectodysplasin a (xenopus tropicalis) (aka ectodysplasin a)
D: ectodysplasin a (sus scrofa) (aka ectodysplasin a)
E: ectd1 (homo ... | [E] |
<Instruct>: Given the context 'Similar to other members of collagenous membrane proteins and members of TNF-related ligands, ectodysplasin is a type II membrane protein and it forms trimers.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one ... | <Mentions>: [ectodysplasin]
<Options>: A: ectodysplasin a (bos taurus) (aka ectodysplasin a)
B: ectodysplasin a (sus scrofa) (aka ectodysplasin a)
C: ectodysplasin a (danio rerio) (aka ectodysplasin a)
D: ectodysplasin a receptor (homo sapiens) (aka ectodysplasin a receptor)
E: ectodysplasin a (homo sapiens) (aka ectod... | [E] |
<Instruct>: Given the context 'The membrane localization of ectodysplasin is asymmetrical: it is found on the apical and lateral surfaces of the cells where it co-localizes with cytoskeletal structures.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected o... | <Mentions>: [ectodysplasin]
<Options>: A: ectodysplasin a (bos taurus) (aka ectodysplasin a)
B: ectodysplasin a (sus scrofa) (aka ectodysplasin a)
C: ectd1 (homo sapiens) (ectodysplasin a (homo sapiens)) (aka ectodysplasin a)
D: ectodysplasin a (danio rerio) (aka ectodysplasin a)
E: ectodysplasin a receptor (xenopus tr... | [C] |
<Instruct>: Given the context 'The membrane localization of ectodysplasin is asymmetrical: it is found on the apical and lateral surfaces of the cells where it co-localizes with cytoskeletal structures.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected o... | <Mentions>: [ectodysplasin]
<Options>: A: ectodysplasin a (sus scrofa) (aka ectodysplasin a)
B: ectodysplasin a (bos taurus) (aka ectodysplasin a)
C: ectodysplasin a receptor (xenopus tropicalis) (aka ectodysplasin a receptor)
D: ectodysplasin a (danio rerio) (aka ectodysplasin a)
E: None of the above. | [E] |
<Instruct>: Given the context 'Our results suggest that ectodysplasin is a new member in the TNF-related ligand family involved in the early epithelial-mesenchymal interaction that regulates ectodermal appendage formation.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [ectodysplasin]
<Options>: A: ectodysplasin a (bos taurus) (aka ectodysplasin a)
B: ectodysplasin a (homo sapiens) (aka ectodysplasin a)
C: ectodysplasin a (sus scrofa) (aka ectodysplasin a)
D: ectodysplasin a receptor (homo sapiens) (aka ectodysplasin a receptor)
E: ectodysplasin a (danio rerio) (aka ectod... | [B] |
<Instruct>: Given the context 'Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death.
Bcl-2 is the best characterized inhibitor of apoptosis, although the molecular basis of this action is not fully understood.', select the correct biomedical concept for each mention using the provided option... | <Mentions>: [bis; bcl-2]
<Options>: A: bis (homo sapiens) (swi/snf related baf chromatin remodeling complex subunit atpase 2 (homo sapiens)) (aka swi/snf related baf chromatin remodeling complex subunit atpase 2)
B: bcl2 interacting protein 2 (homo sapiens) (aka bcl2 interacting protein 2)
C: bcl2 like 2 (homo sapiens)... | [K; H] |
<Instruct>: Given the context 'Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death.
Bcl-2 is the best characterized inhibitor of apoptosis, although the molecular basis of this action is not fully understood.', select the correct biomedical concept for each mention using the provided option... | <Mentions>: [bis; bcl-2]
<Options>: A: bis1 (homo sapiens) (aka ess-2 spliceosome associated protein)
B: bcl2 apoptosis regulator (homo sapiens) (aka bcl2 apoptosis regulator)
C: bisd (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin adenylyltransferase)
D: bis1 (mus musculus) (aka beta-carboline-induced s... | [K; B] |
<Instruct>: Given the context 'Using a protein interaction cloning procedure, we identified a human gene designated as bis (mapped to chromosome 10q25) that encoded a novel Bcl-2-interacting protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opti... | <Mentions>: [bis]
<Options>: A: bis (homo sapiens) (swi/snf related baf chromatin remodeling complex subunit atpase 2 (homo sapiens)) (aka swi/snf related baf chromatin remodeling complex subunit atpase 2)
B: bis1 (homo sapiens) (aka ess-2 spliceosome associated protein)
C: bis1 (mus musculus) (aka beta-carboline-induc... | [F] |
<Instruct>: Given the context 'Bis protein showed no significant homology with Bcl-2 family proteins and had no prominent functional motif.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bis]
<Options>: A: bis (drosophila melanogaster) (aka bistre)
B: bisc (drosophila melanogaster) (aka biscotti)
C: bisd (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin adenylyltransferase)
D: bi (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
E: bisb (escherichia coli str.... | [F] |
<Instruct>: Given the context 'Co-immunoprecipitation analysis confirmed that Bis interacted with Bcl-2 in vivo.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bis; bcl-2]
<Options>: A: bpids (homo sapiens) (aka ubiquitin protein ligase e3b)
B: bcl2 apoptosis regulator (homo sapiens) (aka bcl2 apoptosis regulator)
C: bis (drosophila melanogaster) (aka bistre)
D: bis1 (mus musculus) (aka beta-carboline-induced seizures 1)
E: bis (homo sapiens) (swi/snf related baf... | [K; B] |
<Instruct>: Given the context 'Co-immunoprecipitation analysis confirmed that Bis interacted with Bcl-2 in vivo.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bis; bcl-2]
<Options>: A: bis1 (mus musculus) (aka beta-carboline-induced seizures 1)
B: bis (mus musculus) (aka bcl2-associated athanogene 3)
C: bcl-b (homo sapiens) (aka bcl2 like 10)
D: bis (drosophila melanogaster) (aka bistre)
E: bcl2 apoptosis regulator (homo sapiens) (aka bcl2 apoptosis regulator)
F... | [K; E] |
<Instruct>: Given the context 'DNA transfection experiments indicated that Bis itself exerted only weak anti-apoptotic activity, but was synergistic with Bcl-2 in preventing Bax-induced and Fas-mediated apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [bis; bcl-2; bax; fas]
<Options>: A: bis1 (homo sapiens) (aka ess-2 spliceosome associated protein)
B: bcl-b (homo sapiens) (aka bcl2 like 10)
C: bis (mus musculus) (aka bcl2-associated athanogene 3)
D: bcl-x (homo sapiens) (aka bcl2 like 1)
E: bi (homo sapiens) (aka calcium voltage-gated channel subunit al... | [U; I; N; J] |
<Instruct>: Given the context 'DNA transfection experiments indicated that Bis itself exerted only weak anti-apoptotic activity, but was synergistic with Bcl-2 in preventing Bax-induced and Fas-mediated apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [bis; bcl-2; bax; fas]
<Options>: A: bpids (homo sapiens) (aka ubiquitin protein ligase e3b)
B: bis (homo sapiens) (swi/snf related baf chromatin remodeling complex subunit atpase 2 (homo sapiens)) (aka swi/snf related baf chromatin remodeling complex subunit atpase 2)
C: bak1 (homo sapiens) (aka bcl2 antag... | [U; J; I; F] |
<Instruct>: Given the context 'DNA transfection experiments indicated that Bis itself exerted only weak anti-apoptotic activity, but was synergistic with Bcl-2 in preventing Bax-induced and Fas-mediated apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [bis; bcl-2; bax; fas]
<Options>: A: fasas (homo sapiens) (aka fas antisense rna 1)
B: bax (escherichia coli str. k-12 substr. mg1655) (aka putative glycoside hydrolase bax)
C: bcl2 (homo sapiens) (aka bcl2 apoptosis regulator)
D: bcl2l2 (homo sapiens) (aka bcl2 like 2)
E: fas activated serine/threonine kin... | [U; C; N; F] |
<Instruct>: Given the context 'DNA transfection experiments indicated that Bis itself exerted only weak anti-apoptotic activity, but was synergistic with Bcl-2 in preventing Bax-induced and Fas-mediated apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [bis; bcl-2; bax; fas]
<Options>: A: fasn (homo sapiens) (aka fatty acid synthase)
B: bisb (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin molybdotransferase)
C: bak2 (homo sapiens) (aka bcl2 antagonist/killer 1 pseudogene 1)
D: bak-like (homo sapiens) (aka bcl2 antagonist/killer 1)
E: bcl-b ... | [T; M; P; G] |
<Instruct>: Given the context 'These results suggest that Bis is a novel modulator of cellular anti-apoptotic activity that functions through its interaction with Bcl-2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [bis; bcl-2]
<Options>: A: bpids (homo sapiens) (aka ubiquitin protein ligase e3b)
B: bis (mus musculus) (aka bcl2-associated athanogene 3)
C: bisb (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin molybdotransferase)
D: bcl2 interacting protein 2 (homo sapiens) (aka bcl2 interacting protein 2)... | [K; F] |
<Instruct>: Given the context 'These results suggest that Bis is a novel modulator of cellular anti-apoptotic activity that functions through its interaction with Bcl-2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [bis; bcl-2]
<Options>: A: bcl-b (homo sapiens) (aka bcl2 like 10)
B: bisb (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin molybdotransferase)
C: bisd (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin adenylyltransferase)
D: ccnb2 (homo sapiens) (aka cyclin b2)
E: bis (homo sapie... | [K; H] |
<Instruct>: Given the context 'BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells.
BACKGROUND: Treatment of breast cancer with the antiestrogen tamoxifen is effective in approximately one half of the patients with estrogen receptor-positive disease, but tumors re... | <Mentions>: [bcar1; p130cas]
<Options>: A: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
B: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
C: bca-1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
D: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold p... | [D; D] |
<Instruct>: Given the context 'BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells.
BACKGROUND: Treatment of breast cancer with the antiestrogen tamoxifen is effective in approximately one half of the patients with estrogen receptor-positive disease, but tumors re... | <Mentions>: [bcar1; p130cas]
<Options>: A: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
B: p130cas (xenopus laevis) (bcar1, cas family scaffold protein l homeolog (xenopus laevis)) (aka bcar1, cas family scaffold protein l homeolog)
C: bca1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
D: bcar1... | [E; E] |
<Instruct>: Given the context 'In this study, we isolated and characterized the crucial gene at the breast cancer antiestrogen resistance 1 (BCAR1) locus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [breast cancer antiestrogen resistance 1; bcar1]
<Options>: A: bcar1 (bos taurus) (aka bcar1 scaffold protein, cas family member)
B: breast cancer associated esr1 regulating natural antisense transcript 1 (homo sapiens) (aka breast cancer associated esr1 regulating natural antisense transcript 1)
C: bcan an... | [E; E] |
<Instruct>: Given the context 'In this study, we isolated and characterized the crucial gene at the breast cancer antiestrogen resistance 1 (BCAR1) locus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [breast cancer antiestrogen resistance 1; bcar1]
<Options>: A: bcar1p1 (homo sapiens) (aka bcar1 pseudogene 1)
B: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
C: breast cancer anti-estrogen resistance 4 (homo sapiens) (aka breast cancer anti-estrogen resistance 4)
D: bcar1 scaffold pr... | [D; D] |
<Instruct>: Given the context 'Transfer of the BCAR1 locus from retrovirus-mutated, antiestrogen-resistant cells to estrogen-dependent ZR-75-1 cells by cell fusion conferred an antiestrogen-resistant phenotype on the recipient cells.', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [bcar1]
<Options>: A: bcar1p1 (homo sapiens) (aka bcar1 pseudogene 1)
B: bcar1 (bos taurus) (aka bcar1 scaffold protein, cas family member)
C: bca1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
D: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
E: bcar1 (homo sapiens) (aka bcar1 scaffo... | [E] |
<Instruct>: Given the context 'Transfer of the BCAR1 locus from retrovirus-mutated, antiestrogen-resistant cells to estrogen-dependent ZR-75-1 cells by cell fusion conferred an antiestrogen-resistant phenotype on the recipient cells.', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [bcar1]
<Options>: A: bcar1p1 (homo sapiens) (aka bcar1 pseudogene 1)
B: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
C: bcar1 (bos taurus) (aka bcar1 scaffold protein, cas family member)
D: bca1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
E: None of the above. | [E] |
<Instruct>: Given the context 'The complete coding sequence of BCAR1 was isolated by use of exon-trapping and complementary DNA (cDNA) library screening.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [bcar1]
<Options>: A: bca-1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
B: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
C: bcar1 scaffold protein, cas family member (bos taurus) (aka bcar1 scaffold protein, cas family member)
D: bcar1 pseudogene 1 (homo sapiens) (aka bcar1 ps... | [E] |
<Instruct>: Given the context 'Sequence analysis of human BCAR1 cDNA predicted a protein of 870 amino acids that was strongly homologous to rat p130Cas-adapter protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [bcar1; p130cas-adapter protein]
<Options>: A: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas family member)
B: p120cas (homo sapiens) (aka catenin delta 1)
C: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
D: p130cas (rattus norvegicus) (aka b... | [A; D] |
<Instruct>: Given the context 'Sequence analysis of human BCAR1 cDNA predicted a protein of 870 amino acids that was strongly homologous to rat p130Cas-adapter protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [bcar1; p130cas-adapter protein]
<Options>: A: p130cas (xenopus laevis) (bcar1, cas family scaffold protein l homeolog (xenopus laevis)) (aka bcar1, cas family scaffold protein l homeolog)
B: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas family member)
C: bcar2 (h... | [B; F] |
<Instruct>: Given the context 'Genomic analysis revealed that BCAR1 consists of seven exons and is located at chromosome 16q23.1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcar1]
<Options>: A: bcar1 (homo sapiens) (aka bcar1 scaffold protein, cas family member)
B: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
C: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
D: bca1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
E: bcar1 (bos tauru... | [A] |
<Instruct>: Given the context 'BCAR1 transcripts were detected in multiple human tissues and were similar in size to transcripts produced by retrovirus-mutated ZR-75-1 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [bcar1]
<Options>: A: bcar1 pseudogene 1 (homo sapiens) (aka bcar1 pseudogene 1)
B: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
C: bcar1 (bos taurus) (aka bcar1 scaffold protein, cas family member)
D: bca-1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
E: bcar1 (homo sapiens) (aka ... | [E] |
<Instruct>: Given the context 'Transfection of BCAR1 cDNA into ZR-75-1 cells again resulted in sustained cell proliferation in the presence of antiestrogens, confirming that BCAR1 was the responsible gene in the locus.', select the correct biomedical concept for each mention using the provided options. Answer by listin... | <Mentions>: [bcar1]
<Options>: A: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas family member)
B: bcar1 pseudogene 1 (homo sapiens) (aka bcar1 pseudogene 1)
C: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
D: bca1 (homo sapiens) (aka c-x-c motif chemokin... | [A] |
<Instruct>: Given the context 'Overexpression of the BCAR1 gene confers antiestrogen resistance on human ZR-75-1 breast cancer cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcar1]
<Options>: A: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
B: bcar1 (homo sapiens) (aka bcar1 scaffold protein, cas family member)
C: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
D: bca1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
E: bcar1p1 (homo sa... | [B] |
<Instruct>: Given the context 'Overexpression of BCAR1 in retrovirus-mutated cells appears to result from activation of the gene's promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcar1]
<Options>: A: bcar1 (homo sapiens) (aka bcar1 scaffold protein, cas family member)
B: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
C: bcar1 scaffold protein, cas family member (bos taurus) (aka bcar1 scaffold protein, cas family member)
D: bcar1 pseudogene 1 (homo sapiens) (aka bca... | [A] |
<Instruct>: Given the context 'Overexpression of BCAR1 in retrovirus-mutated cells appears to result from activation of the gene's promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bcar1]
<Options>: A: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
B: bca1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
C: bcar1 pseudogene 1 (homo sapiens) (aka bcar1 pseudogene 1)
D: bcar1 scaffold protein, cas family member (bos taurus) (aka bcar1 scaffold protein, cas family me... | [E] |
<Instruct>: Given the context 'Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [langerin]
<Options>: A: cd207 molecule (homo sapiens) (aka cd207 molecule)
B: cd20l7 (homo sapiens) (aka membrane spanning 4-domains a10)
C: cd209 antigen-like protein a (xenopus tropicalis) (clec9a (xenopus tropicalis)) (aka cd209 antigen-like protein a)
D: cd20l (homo sapiens) (aka membrane spanning 4-do... | [A] |
<Instruct>: Given the context 'We have identified a type II Ca2+-dependent lectin displaying mannose-binding specificity, exclusively expressed by Langerhans cells (LC), and named Langerin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [langerin]
<Options>: A: cd20l5 (homo sapiens) (aka membrane spanning 4-domains a8)
B: cd206 (homo sapiens) (aka mannose receptor c-type 1)
C: cd207 (homo sapiens) (aka cd207 molecule)
D: cd20-like (xenopus tropicalis) (aka membrane spanning 4-domains a1)
E: cd20l7 (homo sapiens) (aka membrane spanning 4-do... | [C] |
<Instruct>: Given the context 'Here, we have shown that Langerin is constitutively associated with BG and that antibody to Langerin is internalized into these structures.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, se... | <Mentions>: [langerin]
<Options>: A: cd206 (homo sapiens) (aka mannose receptor c-type 1)
B: cd208 (homo sapiens) (aka lysosomal associated membrane protein 3)
C: cd207 (homo sapiens) (aka cd207 molecule)
D: cd20l1 (homo sapiens) (aka membrane spanning 4-domains a4a)
E: cd20l7 (homo sapiens) (aka membrane spanning 4-do... | [C] |
<Instruct>: Given the context 'Remarkably, transfection of Langerin cDNA into fibroblasts created a compact network of membrane structures with typical features of BG.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [langerin]
<Options>: A: cd208 (homo sapiens) (aka lysosomal associated membrane protein 3)
B: cd20-like (xenopus tropicalis) (aka membrane spanning 4-domains a1)
C: cd20l (homo sapiens) (aka membrane spanning 4-domains a3)
D: cd207 molecule (homo sapiens) (aka cd207 molecule)
E: cd206 (homo sapiens) (aka m... | [D] |
<Instruct>: Given the context 'Langerin is thus a potent inducer of membrane superimposition and zippering leading to BG formation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [langerin]
<Options>: A: cd206 (homo sapiens) (aka mannose receptor c-type 1)
B: cd20l (homo sapiens) (aka membrane spanning 4-domains a3)
C: cd207 (homo sapiens) (aka cd207 molecule)
D: cd20-like (xenopus tropicalis) (aka membrane spanning 4-domains a1)
E: cd20l1 (homo sapiens) (aka membrane spanning 4-dom... | [C] |
<Instruct>: Given the context 'Our data suggest that induction of BG is a consequence of the antigen-capture function of Langerin, allowing routing into these organelles and providing access to a nonclassical antigen-processing pathway.', select the correct biomedical concept for each mention using the provided options... | <Mentions>: [langerin]
<Options>: A: cd20l (homo sapiens) (aka membrane spanning 4-domains a3)
B: cd209 antigen-like protein a (xenopus tropicalis) (clec9a (xenopus tropicalis)) (aka cd209 antigen-like protein a)
C: cd20-like (xenopus tropicalis) (aka membrane spanning 4-domains a1)
D: cd207 molecule (homo sapiens) (ak... | [D] |
<Instruct>: Given the context 'Cloning and characterisation of the Sry-related transcription factor gene Sox8.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sox8]
<Options>: A: sox8 (homo sapiens) (aka sry-box transcription factor 8)
B: sox8 (xenopus tropicalis) (aka sry-box 8)
C: sox8 (danio rerio) (aka sry-box transcription factor 8b)
D: sox8 (gallus gallus) (aka sry-box 8)
E: sox8 (xenopus laevis) (aka sry-box 8 l homeolog)
F: None of the above. | [A] |
<Instruct>: Given the context 'We report here the isolation of Sox8 and its characterisation in mice and humans.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sox8]
<Options>: A: sox8 (homo sapiens) (aka sry-box transcription factor 8)
B: sox8 (gallus gallus) (aka sry-box 8)
C: sox8 (xenopus tropicalis) (aka sry-box 8)
D: sox8 (mus musculus) (aka sry (sex determining region y)-box 8)
E: sox10 multiple-species conserved sequence 8 (mus musculus) (aka sox10 multip... | [A] |
<Instruct>: Given the context 'This gene has a remarkably similar primary structure and genomic organisation to the campomelic dysplasia gene SOX9 and the Waardenburg-Shah syndrome gene SOX10.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, on... | <Mentions>: [sox9; sox10]
<Options>: A: sry-box transcription factor 9 (homo sapiens) (aka sry-box transcription factor 9)
B: sox9 promoter region (homo sapiens) (aka sox9 promoter region)
C: sox10 (xenopus laevis) (aka sry-box 10 l homeolog)
D: bobby sox homolog (xenopus tropicalis) (aka bobby sox homolog)
E: sry-box ... | [A; I] |
<Instruct>: Given the context 'This gene has a remarkably similar primary structure and genomic organisation to the campomelic dysplasia gene SOX9 and the Waardenburg-Shah syndrome gene SOX10.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, on... | <Mentions>: [sox9; sox10]
<Options>: A: sry-box transcription factor 10 (danio rerio) (aka sry-box transcription factor 10)
B: sox9 (gallus gallus) (aka sry-box 9)
C: sry-box transcription factor 10 (homo sapiens) (aka sry-box transcription factor 10)
D: sox10 (gallus gallus) (aka sry-box 10)
E: bobby sox homolog (xeno... | [J; C] |
<Instruct>: Given the context 'This gene has a remarkably similar primary structure and genomic organisation to the campomelic dysplasia gene SOX9 and the Waardenburg-Shah syndrome gene SOX10.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, on... | <Mentions>: [sox9; sox10]
<Options>: A: bobby sox homolog (xenopus tropicalis) (aka bobby sox homolog)
B: sox9 (xenopus laevis) (sry-box 9 s homeolog (xenopus laevis)) (aka sry-box 9 s homeolog)
C: sry-box transcription factor 9 (homo sapiens) (aka sry-box transcription factor 9)
D: sox9 promoter region (homo sapiens) ... | [C; E] |
<Instruct>: Given the context 'SOX8 protein is able to bind to canonical SOX target DNA sequences and activate transcription in vitro through two separate trans -activation regions.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ... | <Mentions>: [sox8]
<Options>: A: sox8 (sus scrofa) (aka sry-box transcription factor 8)
B: sox8 (xenopus tropicalis) (aka sry-box 8)
C: sry-box 8 (gallus gallus) (aka sry-box 8)
D: sry-box transcription factor 8 (homo sapiens) (aka sry-box transcription factor 8)
E: sox8 (danio rerio) (aka sry-box transcription factor ... | [D] |
<Instruct>: Given the context 'Further, Sox8 is expressed in the central nervous system, limbs, kidneys, gonads and craniofacial structures during mouse embryo development.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [sox8]
<Options>: A: sry-box transcription factor 8 (homo sapiens) (aka sry-box transcription factor 8)
B: sox10 multiple-species conserved sequence 8 (mus musculus) (aka sox10 multiple-species conserved sequence 8)
C: sox8 (danio rerio) (aka sry-box transcription factor 8b)
D: sox8 (xenopus tropicalis) (ak... | [A] |
<Instruct>: Given the context 'Sox8 maps to the t complex on mouse chromosome 17 and to human chromosome 16p13.3, a region associated with the microphthalmia-cataract syndrome CATM and the alpha-thalassemia/mental retardation syndrome ATR-16.', select the correct biomedical concept for each mention using the provided o... | <Mentions>: [sox8]
<Options>: A: sox8 (xenopus tropicalis) (aka sry-box 8)
B: sox10 multiple-species conserved sequence 8 (mus musculus) (aka sox10 multiple-species conserved sequence 8)
C: sox8 (homo sapiens) (aka sry-box transcription factor 8)
D: sox8 (xenopus laevis) (aka sry-box 8 l homeolog)
E: sox8 (gallus gallu... | [C] |
<Instruct>: Given the context 'Syntaphilin: a syntaxin-1 clamp that controls SNARE assembly.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [syntaphilin]
<Options>: A: syntaphilin (homo sapiens) (aka syntaphilin)
B: syntaphilin (rattus norvegicus) (aka syntaphilin)
C: syntaphilin (sus scrofa) (aka syntaphilin)
D: syntaphilin (xenopus tropicalis) (aka syntaphilin)
E: syn1 (drosophila melanogaster) (syntrophin-like 1 (drosophila melanogaster)) (a... | [A] |
<Instruct>: Given the context 'Syntaxin-1 is a key component of the synaptic vesicle docking/fusion machinery that forms the SNARE complex with VAMP/synaptobrevin and SNAP-25.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [snap-25]
<Options>: A: snap-25 (bos taurus) (aka synaptosome associated protein 25)
B: snap-25 (homo sapiens) (aka synaptosome associated protein 25)
C: snap-25 (xenopus laevis) (synaptosome associated protein 25kda s homeolog (xenopus laevis)) (aka synaptosome associated protein 25kda s homeolog)
D: snap2... | [B] |
<Instruct>: Given the context 'We have cloned and characterized a protein called syntaphilin that is selectively expressed in brain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [syntaphilin]
<Options>: A: syn1 (drosophila melanogaster) (syntrophin-like 1 (drosophila melanogaster)) (aka syntrophin-like 1)
B: syntaphilin (bos taurus) (aka syntaphilin)
C: syntaphilin s homeolog (xenopus laevis) (aka syntaphilin s homeolog)
D: syntaphilin (sus scrofa) (aka syntaphilin)
E: syntaphilin ... | [E] |
<Instruct>: Given the context 'Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits SNARE complex formation by absorbing free syntaxin-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [syntaphilin; snap-25]
<Options>: A: snap-25 (mus musculus) (aka synaptosomal-associated protein 25)
B: syn1 (drosophila melanogaster) (synapsin (drosophila melanogaster)) (aka synapsin)
C: syntaphilin (homo sapiens) (aka syntaphilin)
D: synaptosome associated protein 25 (homo sapiens) (aka synaptosome asso... | [C; D] |
<Instruct>: Given the context 'Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits SNARE complex formation by absorbing free syntaxin-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [syntaphilin; snap-25]
<Options>: A: snap-25 (bos taurus) (aka synaptosome associated protein 25)
B: syntaphilin (xenopus tropicalis) (aka syntaphilin)
C: snap-25 (mus musculus) (aka synaptosomal-associated protein 25)
D: syntaphilin (homo sapiens) (aka syntaphilin)
E: syn1 (drosophila melanogaster) (synaps... | [D; J] |
<Instruct>: Given the context 'Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits SNARE complex formation by absorbing free syntaxin-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [syntaphilin; snap-25]
<Options>: A: snap-25 (homo sapiens) (aka synaptosome associated protein 25)
B: snap-25 (xenopus tropicalis) (aka synaptosome associated protein 25kda)
C: snap-25 (xenopus laevis) (synaptosome associated protein 25kda s homeolog (xenopus laevis)) (aka synaptosome associated protein 25... | [G; A] |
<Instruct>: Given the context 'Transient overexpression of syntaphilin in cultured hippocampal neurons significantly reduces neurotransmitter release.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [syntaphilin]
<Options>: A: syntaphilin (xenopus tropicalis) (aka syntaphilin)
B: syntaphilin (homo sapiens) (aka syntaphilin)
C: syn1 (drosophila melanogaster) (syntrophin-like 1 (drosophila melanogaster)) (aka syntrophin-like 1)
D: syntaphilin s homeolog (xenopus laevis) (aka syntaphilin s homeolog)
E: sy... | [B] |
<Instruct>: Given the context 'Furthermore, introduction of syntaphilin into presynaptic superior cervical ganglion neurons in culture inhibits synaptic transmission.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [syntaphilin]
<Options>: A: syntaphilin (bos taurus) (aka syntaphilin)
B: syntaphilin s homeolog (xenopus laevis) (aka syntaphilin s homeolog)
C: syntaphilin (xenopus tropicalis) (aka syntaphilin)
D: syntaphilin (homo sapiens) (aka syntaphilin)
E: syntaphilin (sus scrofa) (aka syntaphilin)
F: None of the ab... | [D] |
<Instruct>: Given the context 'These findings suggest that syntaphilin may function as a molecular clamp that controls free syntaxin-1 availability for the assembly of the SNARE complex, and thereby regulates synaptic vesicle exocytosis.', select the correct biomedical concept for each mention using the provided option... | <Mentions>: [syntaphilin]
<Options>: A: syntaphilin s homeolog (xenopus laevis) (aka syntaphilin s homeolog)
B: syn1 (drosophila melanogaster) (syntrophin-like 1 (drosophila melanogaster)) (aka syntrophin-like 1)
C: syntaphilin (bos taurus) (aka syntaphilin)
D: syntaphilin (sus scrofa) (aka syntaphilin)
E: syntaphilin ... | [E] |
<Instruct>: Given the context 'Human follicle stimulating hormone receptor variants lacking transmembrane domains display altered post-translational conformations.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [human follicle stimulating hormone receptor]
<Options>: A: thyroid stimulating hormone receptor (homo sapiens) (aka thyroid stimulating hormone receptor)
B: gonadotropin releasing hormone receptor (homo sapiens) (aka gonadotropin releasing hormone receptor)
C: follicle stimulating hormone receptor (xenopus... | [D] |
<Instruct>: Given the context 'To determine receptor variant trafficking and intracellular processing in mammalian cells, the intracellular fate of intentionally truncated variants of human follicle stimulating hormone receptor (hFSH-R) expressed in CHO cells was examined.', select the correct biomedical concept for ea... | <Mentions>: [follicle stimulating hormone receptor; hfsh-r]
<Options>: A: follicle stimulating hormone receptor (oryctolagus cuniculus) (aka follicle stimulating hormone receptor)
B: ghsr (homo sapiens) (aka growth hormone secretagogue receptor)
C: follicle stimulating hormone receptor (xenopus tropicalis) (aka follicl... | [E; E] |
<Instruct>: Given the context 'To determine receptor variant trafficking and intracellular processing in mammalian cells, the intracellular fate of intentionally truncated variants of human follicle stimulating hormone receptor (hFSH-R) expressed in CHO cells was examined.', select the correct biomedical concept for ea... | <Mentions>: [follicle stimulating hormone receptor; hfsh-r]
<Options>: A: follicle stimulating hormone receptor (bos taurus) (aka follicle stimulating hormone receptor)
B: ghr (homo sapiens) (aka growth hormone receptor)
C: fshr (sus scrofa) (aka follicle stimulating hormone receptor)
D: tshr (homo sapiens) (aka thyroi... | [G; G] |
<Instruct>: Given the context 'To determine receptor variant trafficking and intracellular processing in mammalian cells, the intracellular fate of intentionally truncated variants of human follicle stimulating hormone receptor (hFSH-R) expressed in CHO cells was examined.', select the correct biomedical concept for ea... | <Mentions>: [follicle stimulating hormone receptor; hfsh-r]
<Options>: A: growth hormone releasing hormone receptor (homo sapiens) (aka growth hormone releasing hormone receptor)
B: follicle stimulating hormone receptor (bos taurus) (aka follicle stimulating hormone receptor)
C: tshr (homo sapiens) (aka thyroid stimula... | [I; I] |
<Instruct>: Given the context 'Epitope mapping using synthetic peptides, and truncated hFSH-R variants revealed that mAb 106.156 bound to ECD residues 183-220, while mAbs 106.318, 106.290, 106.263 bound ECD residues 300-331.', select the correct biomedical concept for each mention using the provided options. Answer by ... | <Mentions>: [hfsh-r]
<Options>: A: ghsr (homo sapiens) (aka growth hormone secretagogue receptor)
B: tshr (homo sapiens) (aka thyroid stimulating hormone receptor)
C: follicle stimulating hormone receptor (homo sapiens) (aka follicle stimulating hormone receptor)
D: ghrhr (homo sapiens) (aka growth hormone releasing ho... | [C] |
<Instruct>: Given the context 'Immunofluorescence microscopy showed that mAbs 106.318 and 106.156 stained the surface of fixed, intact CHO cells expressing wild type hFSH-R. However, following cell permeabilization all four antibodies stained hFSH-R in Golgi and endoplasmic reticulum.', select the correct biomedical co... | <Mentions>: [hfsh-r]
<Options>: A: ghrhr (homo sapiens) (aka growth hormone releasing hormone receptor)
B: ghsr (homo sapiens) (aka growth hormone secretagogue receptor)
C: ghr (homo sapiens) (aka growth hormone receptor)
D: tshr (homo sapiens) (aka thyroid stimulating hormone receptor)
E: follicle stimulating hormone ... | [E] |
<Instruct>: Given the context 'Both glycosylated truncated hFSH-R variants were sensitive to peptide-N-glycanase F and endoglycosidase H but insensitive to neuraminidase indicating that these variants possess high mannose type oligosaccharides.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [hfsh-r; neuraminidase]
<Options>: A: ghr (homo sapiens) (aka growth hormone receptor)
B: tshr (homo sapiens) (aka thyroid stimulating hormone receptor)
C: fshr (homo sapiens) (aka follicle stimulating hormone receptor)
D: growth hormone releasing hormone receptor (homo sapiens) (aka growth hormone releasin... | [C; H] |
<Instruct>: Given the context 'Both glycosylated truncated hFSH-R variants were sensitive to peptide-N-glycanase F and endoglycosidase H but insensitive to neuraminidase indicating that these variants possess high mannose type oligosaccharides.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [hfsh-r; neuraminidase]
<Options>: A: gonadotropin releasing hormone receptor (homo sapiens) (aka gonadotropin releasing hormone receptor)
B: neuraminidase 1 (sus scrofa) (aka neuraminidase 1)
C: follicle stimulating hormone receptor (homo sapiens) (aka follicle stimulating hormone receptor)
D: neuraminidas... | [C; F] |
<Instruct>: Given the context 'Thus truncated hFSH-R variants do not reach the medial or trans Golgi where high mannose oligosaccharides are trimmed and sialic acid is added.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [hfsh-r]
<Options>: A: gonadotropin releasing hormone receptor (homo sapiens) (aka gonadotropin releasing hormone receptor)
B: ghr (homo sapiens) (aka growth hormone receptor)
C: thyroid stimulating hormone receptor (homo sapiens) (aka thyroid stimulating hormone receptor)
D: ghsr (homo sapiens) (aka growth... | [E] |
<Instruct>: Given the context 'The pro-alpha3(V) collagen chain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pro-alpha3(v) collagen]
<Options>: A: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
B: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
C: collagen type v alpha 3 chain (bos taurus) (aka collagen type v alpha 3 chain)
D: collagen type v alp... | [B] |
<Instruct>: Given the context 'The low abundance fibrillar collagen type V is widely distributed in tissues as an alpha1(V)(2)alpha2(V) heterotrimer that helps regulate the diameters of fibrils of the abundant collagen type I. Mutations in the alpha1(V) and alpha2(V) chain genes have been identified in some cases of cl... | <Mentions>: [alpha1(v); alpha2(v)]
<Options>: A: vla-2 (homo sapiens) (aka integrin subunit alpha 2)
B: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
C: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
D: collagen type xv alpha 1 chain (homo sapiens) (aka collagen type xv alpha 1 chain)
E: col... | [F; H] |
<Instruct>: Given the context 'The low abundance fibrillar collagen type V is widely distributed in tissues as an alpha1(V)(2)alpha2(V) heterotrimer that helps regulate the diameters of fibrils of the abundant collagen type I. Mutations in the alpha1(V) and alpha2(V) chain genes have been identified in some cases of cl... | <Mentions>: [alpha1(v); alpha2(v)]
<Options>: A: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
B: vla5a (homo sapiens) (aka integrin subunit alpha 5)
C: collagen type vi alpha 2 chain (homo sapiens) (aka collagen type vi alpha 2 chain)
D: collagen type xxv alpha 1 chain (homo sapiens) (aka coll... | [H; I] |
<Instruct>: Given the context 'The low abundance fibrillar collagen type V is widely distributed in tissues as an alpha1(V)(2)alpha2(V) heterotrimer that helps regulate the diameters of fibrils of the abundant collagen type I. Mutations in the alpha1(V) and alpha2(V) chain genes have been identified in some cases of cl... | <Mentions>: [alpha1(v); alpha2(v)]
<Options>: A: collagen type v alpha 2 chain (sus scrofa) (aka collagen type v alpha 2 chain)
B: integrin subunit alpha v (homo sapiens) (aka integrin subunit alpha v)
C: vlaa2 (homo sapiens) (aka integrin subunit alpha 2)
D: collagen type xv alpha 1 chain (homo sapiens) (aka collagen ... | [F; I] |
<Instruct>: Given the context 'Type V collagen also exists as an alpha1(V)alpha2(V)alpha3(V) heterotrimer that has remained poorly characterized chiefly due to inability to obtain the complete primary structure or nucleic acid probes for the alpha3(V) chain or its biosynthetic precursor, pro-alpha3(V).', select the cor... | <Mentions>: [alpha1(v); alpha2(v); alpha3(v)]
<Options>: A: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
B: collagen type v alpha 2 chain (rattus norvegicus) (aka collagen type v alpha 2 chain)
C: collagen type v alpha 3 chain (xenopus tropicalis) (aka collagen type v alpha 3 chain)
... | [L; F; A] |
<Instruct>: Given the context 'Type V collagen also exists as an alpha1(V)alpha2(V)alpha3(V) heterotrimer that has remained poorly characterized chiefly due to inability to obtain the complete primary structure or nucleic acid probes for the alpha3(V) chain or its biosynthetic precursor, pro-alpha3(V).', select the cor... | <Mentions>: [alpha1(v); alpha2(v); alpha3(v)]
<Options>: A: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
B: vlaa2 (homo sapiens) (aka integrin subunit alpha 2)
C: collagen type xiv alpha 1 chain (homo sapiens) (aka collagen type xiv alpha 1 chain)
D: collagen type v alpha 2 chain (gallus gallus) (aka collagen type... | [I; J; E] |
<Instruct>: Given the context 'Type V collagen also exists as an alpha1(V)alpha2(V)alpha3(V) heterotrimer that has remained poorly characterized chiefly due to inability to obtain the complete primary structure or nucleic acid probes for the alpha3(V) chain or its biosynthetic precursor, pro-alpha3(V).', select the cor... | <Mentions>: [alpha1(v); alpha2(v); alpha3(v)]
<Options>: A: collagen type v alpha 3 chain (rattus norvegicus) (aka collagen type v alpha 3 chain)
B: collagen type v alpha 2 chain (sus scrofa) (aka collagen type v alpha 2 chain)
C: integrin subunit alpha v (rattus norvegicus) (aka integrin subunit alpha v)
D: collagen t... | [N; F; M] |
<Instruct>: Given the context 'Type V collagen also exists as an alpha1(V)alpha2(V)alpha3(V) heterotrimer that has remained poorly characterized chiefly due to inability to obtain the complete primary structure or nucleic acid probes for the alpha3(V) chain or its biosynthetic precursor, pro-alpha3(V).', select the cor... | <Mentions>: [pro-alpha3(v)]
<Options>: A: collagen, type v, alpha 1 s homeolog (xenopus laevis) (aka collagen, type v, alpha 1 s homeolog)
B: apoa-v (xenopus tropicalis) (aka apolipoprotein a5)
C: collagen type v alpha 3 s homeolog (xenopus laevis) (aka collagen type v alpha 3 s homeolog)
D: collagen type v alpha 3 cha... | [D] |
<Instruct>: Given the context 'Pro-alpha3(V) is shown to be closely related to the alpha1(V) precursor, pro-alpha1(V), but with marked differences in N-propeptide sequences, and collagenous domain features that provide insights into the low melting temperature of alpha1(V)alpha2(V)alpha3(V)', select the correct biomedi... | <Mentions>: [pro-alpha3(v); alpha1(v); pro-alpha1(v)]
<Options>: A: collagen, type v, alpha 1 (xenopus tropicalis) (aka collagen, type v, alpha 1)
B: procollagen, type v, alpha 1 (danio rerio) (aka procollagen, type v, alpha 1)
C: vla5a (homo sapiens) (aka integrin subunit alpha 5)
D: collagen type v alpha 3 chain (sus... | [K; L; L] |
<Instruct>: Given the context 'Pro-alpha3(V) is shown to be closely related to the alpha1(V) precursor, pro-alpha1(V), but with marked differences in N-propeptide sequences, and collagenous domain features that provide insights into the low melting temperature of alpha1(V)alpha2(V)alpha3(V)', select the correct biomedi... | <Mentions>: [pro-alpha3(v); alpha1(v); pro-alpha1(v)]
<Options>: A: apoa-v (xenopus tropicalis) (aka apolipoprotein a5)
B: vla5a (homo sapiens) (aka integrin subunit alpha 5)
C: collagen, type v, alpha 1 (xenopus tropicalis) (aka collagen, type v, alpha 1)
D: collagen type v alpha 3 chain (homo sapiens) (aka collagen t... | [D; H; H] |
<Instruct>: Given the context 'Pro-alpha3(V) is shown to be closely related to the alpha1(V) precursor, pro-alpha1(V), but with marked differences in N-propeptide sequences, and collagenous domain features that provide insights into the low melting temperature of alpha1(V)alpha2(V)alpha3(V)', select the correct biomedi... | <Mentions>: [pro-alpha3(v); alpha1(v); pro-alpha1(v)]
<Options>: A: apoa-v (rattus norvegicus) (aka apolipoprotein a5)
B: apoa-v (xenopus tropicalis) (aka apolipoprotein a5)
C: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
D: collagen type v alpha 1 chain (sus scrofa) (aka collagen ty... | [I; C; C] |
<Instruct>: Given the context 'Pro-alpha3(V) is shown to be closely related to the alpha1(V) precursor, pro-alpha1(V), but with marked differences in N-propeptide sequences, and collagenous domain features that provide insights into the low melting temperature of alpha1(V)alpha2(V)alpha3(V)', select the correct biomedi... | <Mentions>: [alpha2(v); alpha3(v)]
<Options>: A: collagen type vi alpha 2 chain (homo sapiens) (aka collagen type vi alpha 2 chain)
B: collagen type v alpha 3 chain (rattus norvegicus) (aka collagen type v alpha 3 chain)
C: collagen type v alpha 3 chain (xenopus tropicalis) (aka collagen type v alpha 3 chain)
D: collag... | [D; F] |
<Instruct>: Given the context 'Pro-alpha3(V) is shown to be closely related to the alpha1(V) precursor, pro-alpha1(V), but with marked differences in N-propeptide sequences, and collagenous domain features that provide insights into the low melting temperature of alpha1(V)alpha2(V)alpha3(V)', select the correct biomedi... | <Mentions>: [alpha2(v); alpha3(v)]
<Options>: A: collagen type v alpha 3 s homeolog (xenopus laevis) (aka collagen type v alpha 3 s homeolog)
B: vla5a (homo sapiens) (aka integrin subunit alpha 5)
C: collagen type vi alpha 3 chain (homo sapiens) (aka collagen type vi alpha 3 chain)
D: collagen type v alpha 3 chain (hom... | [E; D] |
<Instruct>: Given the context 'heterotrimers, lack of heparin binding by alpha3(V) chains and the possibility that alpha1(V)alpha2(V)alpha3(V)', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha3(v); alpha1(v); alpha2(v)]
<Options>: A: collagen type v alpha 3 chain (rattus norvegicus) (aka collagen type v alpha 3 chain)
B: vla3a (homo sapiens) (aka integrin subunit alpha 3)
C: collagen type v alpha 2 chain (sus scrofa) (aka collagen type v alpha 2 chain)
D: collagen type v alpha 2 chain (hom... | [M; F; D] |
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