instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
|---|---|---|
<Instruct>: Given the context 'heterotrimers, lack of heparin binding by alpha3(V) chains and the possibility that alpha1(V)alpha2(V)alpha3(V)', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha3(v); alpha1(v); alpha2(v)]
<Options>: A: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
B: collagen type v alpha 2 chain (homo sapiens) (aka collagen type v alpha 2 chain)
C: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
D: collagen type v alpha 3 chain (xenopus ... | [A; G; B] |
<Instruct>: Given the context 'heterotrimers, lack of heparin binding by alpha3(V) chains and the possibility that alpha1(V)alpha2(V)alpha3(V)', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha3(v); alpha1(v); alpha2(v)]
<Options>: A: collagen type xv alpha 1 chain (homo sapiens) (aka collagen type xv alpha 1 chain)
B: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
C: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
D: integrin subunit alpha v (xenopus tro... | [E; B; F] |
<Instruct>: Given the context 'In situ hybridization of mouse embryos detects alpha3(V) expression primarily in the epimysial sheaths of developing muscles and within nascent ligaments adjacent to forming bones and in joints.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [alpha3(v)]
<Options>: A: integrin subunit alpha v (xenopus tropicalis) (aka integrin subunit alpha v)
B: collagen type v alpha 3 chain (xenopus tropicalis) (aka collagen type v alpha 3 chain)
C: vla3a (homo sapiens) (aka integrin subunit alpha 3)
D: collagen type v alpha 3 chain (sus scrofa) (aka collagen ... | [F] |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least som... | <Mentions>: [alpha1(v); alpha2(v); alpha3(v)]
<Options>: A: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
B: collagen type xiv alpha 1 chain (homo sapiens) (aka collagen type xiv alpha 1 chain)
C: collagen type vi alpha 3 chain (homo sapiens) (aka collagen type vi alpha 3 chain)
D: in... | [J; I; A] |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least som... | <Mentions>: [alpha1(v); alpha2(v); alpha3(v)]
<Options>: A: vla5a (homo sapiens) (aka integrin subunit alpha 5)
B: collagen type v alpha 3 chain (sus scrofa) (aka collagen type v alpha 3 chain)
C: vla-2 (homo sapiens) (aka integrin subunit alpha 2)
D: integrin subunit alpha v (xenopus tropicalis) (aka integrin subunit ... | [M; J; H] |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least som... | <Mentions>: [alpha1(v); alpha2(v); alpha3(v)]
<Options>: A: collagen type v alpha 2 chain (sus scrofa) (aka collagen type v alpha 2 chain)
B: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
C: integrin subunit alpha v (rattus norvegicus) (aka integrin subunit alpha v)
D: collagen type v... | [L; G; B] |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least som... | <Mentions>: [col5a3; alpha1(v); alpha2(v)]
<Options>: A: col6a5 (homo sapiens) (aka collagen type vi alpha 5 chain)
B: collagen type v alpha 2 chain (homo sapiens) (aka collagen type v alpha 2 chain)
C: collagen type v alpha 1 chain (sus scrofa) (aka collagen type v alpha 1 chain)
D: collagen type v alpha 1 chain (homo... | [O; D; B] |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least som... | <Mentions>: [col5a3; alpha1(v); alpha2(v)]
<Options>: A: col6a3 (homo sapiens) (aka collagen type vi alpha 3 chain)
B: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
C: col4a5 (homo sapiens) (aka collagen type iv alpha 5 chain)
D: collagen type v alpha 1 chain (sus scrofa) (aka collage... | [H; B; L] |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least som... | <Mentions>: [col5a3; alpha1(v); alpha2(v)]
<Options>: A: collagen type v alpha 2 chain (gallus gallus) (aka collagen type v alpha 2 chain)
B: collagen type xxv alpha 1 chain (homo sapiens) (aka collagen type xxv alpha 1 chain)
C: collagen type v alpha 2 chain (rattus norvegicus) (aka collagen type v alpha 2 chain)
D: i... | [E; N; I] |
<Instruct>: Given the context 'This distribution, and the association of alpha1(V), alpha2(V), and alpha3(V) chains in heterotrimers, suggests the human alpha3(V) gene COL5A3 as a candidate locus for at least some cases of classical EDS in which the alpha1(V) and alpha2(V) genes have been excluded, and for at least som... | <Mentions>: [col5a3; alpha1(v); alpha2(v)]
<Options>: A: vla-2 (homo sapiens) (aka integrin subunit alpha 2)
B: col5a2 (homo sapiens) (aka collagen type v alpha 2 chain)
C: col6a5 (homo sapiens) (aka collagen type vi alpha 5 chain)
D: collagen type v alpha 1 chain (homo sapiens) (aka collagen type v alpha 1 chain)
E: c... | [L; D; N] |
<Instruct>: Given the context 'COL5A3 is mapped to 19p13.2 near a polymorphic marker that should be useful in analyzing linkage with EDS and other disease phenotypes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [col5a3]
<Options>: A: col5a3 (sus scrofa) (aka collagen type v alpha 3 chain)
B: col4a3 (homo sapiens) (aka collagen type iv alpha 3 chain)
C: col5a1 (homo sapiens) (aka collagen type v alpha 1 chain)
D: collagen type v alpha 3 chain (homo sapiens) (aka collagen type v alpha 3 chain)
E: col6a3 (homo sapien... | [D] |
<Instruct>: Given the context 'Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal degradation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [mdm2; p53]
<Options>: A: p53 (homo sapiens) (aka tumor protein p53)
B: hdmx (homo sapiens) (mdm2 proto-oncogene (homo sapiens)) (aka mdm2 proto-oncogene)
C: ct53 (homo sapiens) (aka zinc finger protein 165)
D: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member... | [B; A] |
<Instruct>: Given the context 'Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal degradation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [mdm2; p53]
<Options>: A: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
B: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiquitin protein ligase pseudogene)
C: mdm2 binding protein (homo sapiens) (aka mdm2 binding protein)
D: ct53 (homo sapiens) (aka zinc fing... | [G; F] |
<Instruct>: Given the context 'Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal degradation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [p53]
<Options>: A: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
B: tumor protein p53 (homo sapiens) (aka tumor protein p53)
C: p53cp (homo sapiens) (aka tumor protein p63)
D: rad53 (homo sapiens) (aka checkpoint kinase 2)
E: ct53 (homo sapiens) (aka z... | [B] |
<Instruct>: Given the context 'We now report that Mdm2 is a ubiquitin protein ligase (E3) for p53 and that its activity is dependent on its RING finger.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicol... | <Mentions>: [mdm2; p53]
<Options>: A: mdm2bp (homo sapiens) (aka mdm2 binding protein)
B: rad53 (homo sapiens) (aka checkpoint kinase 2)
C: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
D: tp73 (homo sapiens) (aka tumor protein p73)
E: mdm2, transformed 3t3 cell double minute p53 binding protein (mus musculus) (aka md... | [I; G] |
<Instruct>: Given the context 'We now report that Mdm2 is a ubiquitin protein ligase (E3) for p53 and that its activity is dependent on its RING finger.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicol... | <Mentions>: [mdm2; p53]
<Options>: A: mdm2 (mus musculus) (aka transformed mouse 3t3 cell double minute 2)
B: p53 (homo sapiens) (aka tumor protein p53)
C: mdm1 (homo sapiens) (aka mdm1 nuclear protein)
D: p53cp (homo sapiens) (aka tumor protein p63)
E: rad53 (homo sapiens) (aka checkpoint kinase 2)
F: mdm2bp (homo sap... | [G; B] |
<Instruct>: Given the context 'Furthermore, we show that Mdm2 mediates its own ubiquitination in a RING finger-dependent manner, which requires no eukaryotic proteins other than ubiquitin-activating enzyme (E1) and an ubiquitin-conjugating enzyme (E2).', select the correct biomedical concept for each mention using the ... | <Mentions>: [mdm2; ubiquitin-activating enzyme (e1)]
<Options>: A: hdmx (homo sapiens) (mdm2 proto-oncogene (homo sapiens)) (aka mdm2 proto-oncogene)
B: nedd8 activating enzyme e1 subunit 1 (homo sapiens) (aka nedd8 activating enzyme e1 subunit 1)
C: mdm2, transformed 3t3 cell double minute p53 binding protein (mus mus... | [A; H] |
<Instruct>: Given the context 'Furthermore, we show that Mdm2 mediates its own ubiquitination in a RING finger-dependent manner, which requires no eukaryotic proteins other than ubiquitin-activating enzyme (E1) and an ubiquitin-conjugating enzyme (E2).', select the correct biomedical concept for each mention using the ... | <Mentions>: [mdm2; ubiquitin-activating enzyme (e1)]
<Options>: A: ubiquitin like modifier activating enzyme 7 (homo sapiens) (aka ubiquitin like modifier activating enzyme 7)
B: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiquitin protein ligase pseudogene)
C: mdm2 (mus... | [I; A] |
<Instruct>: Given the context 'It is apparent, therefore, that Mdm2 manifests an intrinsic capacity to mediate ubiquitination.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mdm2]
<Options>: A: mdm2, transformed 3t3 cell double minute p53 binding protein (mus musculus) (aka mdm2, transformed 3t3 cell double minute p53 binding protein)
B: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka mdm2 oncogene, e3 ubiquitin protein ligase pseudogene)
C: mdm2 (hom... | [C] |
<Instruct>: Given the context 'We further demonstrate that the degradation of p53 and Mdm2 in cells requires additional potential zinc-coordinating residues beyond those required for the intrinsic activity of Mdm2 in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by l... | <Mentions>: [p53; mdm2]
<Options>: A: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
B: hdm2 (homo sapiens) (aka mdm2 proto-oncogene)
C: p53 (homo sapiens) (aka tumor protein p53)
D: mdm2, transformed 3t3 cell double minute p53 binding protein (mus musculus) (aka md... | [C; B] |
<Instruct>: Given the context 'We further demonstrate that the degradation of p53 and Mdm2 in cells requires additional potential zinc-coordinating residues beyond those required for the intrinsic activity of Mdm2 in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by l... | <Mentions>: [p53; mdm2]
<Options>: A: mdm2, transformed 3t3 cell double minute p53 binding protein (mus musculus) (aka mdm2, transformed 3t3 cell double minute p53 binding protein)
B: tumor protein p73 (homo sapiens) (aka tumor protein p73)
C: mdm2 oncogene, e3 ubiquitin protein ligase pseudogene (homo sapiens) (aka md... | [J; E] |
<Instruct>: Given the context 'We further demonstrate that the degradation of p53 and Mdm2 in cells requires additional potential zinc-coordinating residues beyond those required for the intrinsic activity of Mdm2 in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by l... | <Mentions>: [p53; mdm2]
<Options>: A: rad53 (homo sapiens) (aka checkpoint kinase 2)
B: p53cp (homo sapiens) (aka tumor protein p63)
C: mdm2, transformed 3t3 cell double minute p53 binding protein (mus musculus) (aka mdm2, transformed 3t3 cell double minute p53 binding protein)
D: mdm2 (mus musculus) (aka transformed m... | [I; E] |
<Instruct>: Given the context 'Replacement of the Mdm2 RING with that of another protein (Praja1) reconstituted ubiquitination and proteasomal degradation of Mdm2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [mdm2; praja1]
<Options>: A: mdm2 binding protein (homo sapiens) (aka mdm2 binding protein)
B: mdm2 (mus musculus) (aka transformed mouse 3t3 cell double minute 2)
C: praja ring finger ubiquitin ligase 1 (bos taurus) (aka praja ring finger ubiquitin ligase 1)
D: praja ring finger ubiquitin ligase 2 (homo sa... | [G; J] |
<Instruct>: Given the context 'Replacement of the Mdm2 RING with that of another protein (Praja1) reconstituted ubiquitination and proteasomal degradation of Mdm2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [mdm2; praja1]
<Options>: A: praja1 (homo sapiens) (aka praja ring finger ubiquitin ligase 1)
B: mdm2 binding protein (homo sapiens) (aka mdm2 binding protein)
C: keratin associated protein 1-1 (homo sapiens) (aka keratin associated protein 1-1)
D: e3 ubiquitin-protein ligase praja-2 (glycine max) (aka e3 u... | [I; A] |
<Instruct>: Given the context 'However, this RING was ineffective in ubiquitination and proteasomal targeting of p53, suggesting that there may be specificity at the level of the RING in the recognition of heterologous substrates.', select the correct biomedical concept for each mention using the provided options. Answ... | <Mentions>: [p53]
<Options>: A: ct53 (homo sapiens) (aka zinc finger protein 165)
B: p53cp (homo sapiens) (aka tumor protein p63)
C: rad53 (homo sapiens) (aka checkpoint kinase 2)
D: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
E: tumor protein p53 (homo sapiens) ... | [E] |
<Instruct>: Given the context 'Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins.
CD34 and podocalyxin are structurally related sialomucins, which are expressed in multiple tissues including vascular endothelium and hematopoietic progenitors.', select the correct biomedical concept fo... | <Mentions>: [endoglycan; cd34; podocalyxin]
<Options>: A: matrix extracellular phosphoglycoprotein (homo sapiens) (aka matrix extracellular phosphoglycoprotein)
B: podn (homo sapiens) (aka podocan)
C: podocalyxin like (homo sapiens) (aka podocalyxin like)
D: cd340 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
... | [O; I; C] |
<Instruct>: Given the context 'Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins.
CD34 and podocalyxin are structurally related sialomucins, which are expressed in multiple tissues including vascular endothelium and hematopoietic progenitors.', select the correct biomedical concept fo... | <Mentions>: [endoglycan; cd34; podocalyxin]
<Options>: A: cd34 molecule (gallus gallus) (aka cd34 molecule)
B: cd344 (homo sapiens) (aka frizzled class receptor 4)
C: betaglycan (rattus norvegicus) (aka transforming growth factor beta receptor 3)
D: endocan (homo sapiens) (aka endothelial cell specific molecule 1)
E: c... | [F; I; O] |
<Instruct>: Given the context 'Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins.
CD34 and podocalyxin are structurally related sialomucins, which are expressed in multiple tissues including vascular endothelium and hematopoietic progenitors.', select the correct biomedical concept fo... | <Mentions>: [endoglycan; cd34; podocalyxin]
<Options>: A: eg (homo sapiens) (aka podocalyxin like 2)
B: podocalyxin like (homo sapiens) (aka podocalyxin like)
C: nectin-4 (homo sapiens) (aka nectin cell adhesion molecule 4)
D: podocalyxin like (xenopus tropicalis) (aka podocalyxin like)
E: podocalyxin like (gallus gall... | [A; H; B] |
<Instruct>: Given the context 'Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins.
CD34 and podocalyxin are structurally related sialomucins, which are expressed in multiple tissues including vascular endothelium and hematopoietic progenitors.', select the correct biomedical concept fo... | <Mentions>: [endoglycan; cd34; podocalyxin]
<Options>: A: podocalyxin like (oryctolagus cuniculus) (aka podocalyxin like)
B: podocalyxin-like (homo sapiens) (aka podocalyxin-like)
C: megcann (homo sapiens) (aka clpb family mitochondrial disaggregase)
D: cd344 (homo sapiens) (aka frizzled class receptor 4)
E: bgcan (hom... | [H; I; G] |
<Instruct>: Given the context 'Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins.
CD34 and podocalyxin are structurally related sialomucins, which are expressed in multiple tissues including vascular endothelium and hematopoietic progenitors.', select the correct biomedical concept fo... | <Mentions>: [podocalyxin]
<Options>: A: podocalyxin like (oryctolagus cuniculus) (aka podocalyxin like)
B: podocalyxin-like (rattus norvegicus) (aka podocalyxin-like)
C: podocalyxin like s homeolog (xenopus laevis) (aka podocalyxin like s homeolog)
D: podocalyxin like (homo sapiens) (aka podocalyxin like)
E: podocalyxi... | [D] |
<Instruct>: Given the context 'Using homologies present in the cytoplasmic tails of these proteins, we have identified a novel member of this family, which we designate endoglycan.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [endoglycan]
<Options>: A: betaglycan (rattus norvegicus) (aka transforming growth factor beta receptor 3)
B: eg (homo sapiens) (aka podocalyxin like 2)
C: endocan (homo sapiens) (aka endothelial cell specific molecule 1)
D: endomucin (homo sapiens) (aka endomucin)
E: betaglycan (homo sapiens) (aka transfor... | [B] |
<Instruct>: Given the context 'In addition, endoglycan contains several potential glycosaminoglycan attachment sites and is modified with chondroitin sulfate.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [endoglycan]
<Options>: A: eg (homo sapiens) (aka podocalyxin like 2)
B: endoglin (homo sapiens) (aka endoglin)
C: betaglycan (homo sapiens) (aka transforming growth factor beta receptor 3)
D: endocan (homo sapiens) (aka endothelial cell specific molecule 1)
E: megcann (homo sapiens) (aka clpb family mitoch... | [A] |
<Instruct>: Given the context 'Endoglycan mRNA and protein were detected in both endothelial cells and CD34(+) bone marrow cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [endoglycan]
<Options>: A: betaglycan (rattus norvegicus) (aka transforming growth factor beta receptor 3)
B: endocan (homo sapiens) (aka endothelial cell specific molecule 1)
C: eg (homo sapiens) (aka podocalyxin like 2)
D: endoglin (homo sapiens) (aka endoglin)
E: megcann (homo sapiens) (aka clpb family m... | [C] |
<Instruct>: Given the context 'Endoglycan mRNA and protein were detected in both endothelial cells and CD34(+) bone marrow cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [endoglycan]
<Options>: A: endocan (homo sapiens) (aka endothelial cell specific molecule 1)
B: endoglin (homo sapiens) (aka endoglin)
C: megcann (homo sapiens) (aka clpb family mitochondrial disaggregase)
D: betaglycan (rattus norvegicus) (aka transforming growth factor beta receptor 3)
E: None of the abov... | [E] |
<Instruct>: Given the context 'Thus, CD34, podocalyxin, and endoglycan comprise a family of sialomucins sharing both structural similarity and sequence homology, which are expressed by both endothelium and multipotent hematopoietic progenitors.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [cd34; podocalyxin; endoglycan]
<Options>: A: cd340 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
B: cd34 molecule (homo sapiens) (aka cd34 molecule)
C: endomucin (homo sapiens) (aka endomucin)
D: podn (homo sapiens) (aka podocan)
E: nectin-4 (homo sapiens) (aka nectin cell adhesion molecule 4)
F: ... | [B; O; M] |
<Instruct>: Given the context 'Thus, CD34, podocalyxin, and endoglycan comprise a family of sialomucins sharing both structural similarity and sequence homology, which are expressed by both endothelium and multipotent hematopoietic progenitors.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [cd34; podocalyxin; endoglycan]
<Options>: A: endocan (homo sapiens) (aka endothelial cell specific molecule 1)
B: cd34 (gallus gallus) (aka cd34 molecule)
C: betaglycan (rattus norvegicus) (aka transforming growth factor beta receptor 3)
D: eg (homo sapiens) (aka podocalyxin like 2)
E: podocalyxin like (xe... | [J; K; D] |
<Instruct>: Given the context 'Thus, CD34, podocalyxin, and endoglycan comprise a family of sialomucins sharing both structural similarity and sequence homology, which are expressed by both endothelium and multipotent hematopoietic progenitors.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [cd34; podocalyxin; endoglycan]
<Options>: A: podocalyxin like (xenopus tropicalis) (aka podocalyxin like)
B: megcann (homo sapiens) (aka clpb family mitochondrial disaggregase)
C: fat4 (homo sapiens) (aka fat atypical cadherin 4)
D: eg (homo sapiens) (aka podocalyxin like 2)
E: cd114 (homo sapiens) (aka co... | [F; M; D] |
<Instruct>: Given the context 'While the members of this family may perform overlapping functions at these sites, the unique structural features of endoglycan suggest distinct functions for this molecule.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [endoglycan]
<Options>: A: matrix extracellular phosphoglycoprotein (homo sapiens) (aka matrix extracellular phosphoglycoprotein)
B: betaglycan (rattus norvegicus) (aka transforming growth factor beta receptor 3)
C: endoglin (sus scrofa) (aka endoglin)
D: endomucin (homo sapiens) (aka endomucin)
E: eg (homo... | [E] |
<Instruct>: Given the context 'While the members of this family may perform overlapping functions at these sites, the unique structural features of endoglycan suggest distinct functions for this molecule.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [endoglycan]
<Options>: A: betaglycan (rattus norvegicus) (aka transforming growth factor beta receptor 3)
B: endoglin (sus scrofa) (aka endoglin)
C: matrix extracellular phosphoglycoprotein (homo sapiens) (aka matrix extracellular phosphoglycoprotein)
D: endomucin (homo sapiens) (aka endomucin)
E: None of ... | [E] |
<Instruct>: Given the context 'Using one of the inhibitory mAbs, 8D6, we expression cloned the cDNA encoding the 8D6 antigen (Ag) from a human FDC line, HK.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [8d6; 8d6 antigen (ag)]
<Options>: A: 8d6 (homo sapiens) (aka cd320 molecule)
B: eg:8d8.8 (drosophila melanogaster) (aka mitochondrial poly(a) polymerase)
C: mer6 (homo sapiens) (aka cd47 molecule)
D: ly-6d (homo sapiens) (aka lymphocyte antigen 6 family member d)
E: dermatitis, atopic, 6 (homo sapiens) (ak... | [A; A] |
<Instruct>: Given the context 'Using one of the inhibitory mAbs, 8D6, we expression cloned the cDNA encoding the 8D6 antigen (Ag) from a human FDC line, HK.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [8d6; 8d6 antigen (ag)]
<Options>: A: 8d6 (homo sapiens) (aka cd320 molecule)
B: dermatitis, atopic, 6 (homo sapiens) (aka dermatitis, atopic, 6)
C: ly6g6 (homo sapiens) (aka lymphocyte antigen 6 family member g6f)
D: eg:8d8.8 (drosophila melanogaster) (aka mitochondrial poly(a) polymerase)
E: 8d8.1 (drosop... | [A; A] |
<Instruct>: Given the context 'The 8D6 Ag is a novel protein of 282 amino acids that is expressed abundantly on FDCs.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [8d6 ag]
<Options>: A: ly-6d (homo sapiens) (aka lymphocyte antigen 6 family member d)
B: 8d6a (homo sapiens) (aka cd320 molecule)
C: 8d6 (mus musculus) (aka cd320 antigen)
D: 6c6-ag (homo sapiens) (aka b cell receptor associated protein 31)
E: ly6g6 (homo sapiens) (aka lymphocyte antigen 6 family member g6... | [B] |
<Instruct>: Given the context 'Monolayers of COS cells transiently transfected with the 8D6 Ag cDNA stimulate B cell growth.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [8d6 ag]
<Options>: A: ly-6d (homo sapiens) (aka lymphocyte antigen 6 family member d)
B: 8d6a (homo sapiens) (aka cd320 molecule)
C: tetraspanin 6 (homo sapiens) (aka tetraspanin 6)
D: 8d6 (mus musculus) (aka cd320 antigen)
E: ly6g6 (homo sapiens) (aka lymphocyte antigen 6 family member g6f)
F: None of the... | [B] |
<Instruct>: Given the context 'The mAb 8D6 blocks the costimulatory function completely.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [8d6]
<Options>: A: 8d6 (mus musculus) (aka cd320 antigen)
B: defa6 (homo sapiens) (aka defensin alpha 6)
C: d6 (homo sapiens) (aka atypical chemokine receptor 2)
D: eg:8d8.8 (drosophila melanogaster) (aka mitochondrial poly(a) polymerase)
E: 8d6a (homo sapiens) (aka cd320 molecule)
F: None of the above. | [E] |
<Instruct>: Given the context 'The inhibitory activity of the mAb 8D6 was demonstrated to be due to an inhibition of cell cycle progression of CD40 ligand-stimulated GC B cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [8d6; cd40]
<Options>: A: eg:8d8.6 (drosophila melanogaster) (aka n(alpha)-acetyltransferase 30 a)
B: eg:8d8.8 (drosophila melanogaster) (aka mitochondrial poly(a) polymerase)
C: cd40 molecule (oryctolagus cuniculus) (aka cd40 molecule)
D: d6 (homo sapiens) (aka atypical chemokine receptor 2)
E: tnf recepto... | [H; F] |
<Instruct>: Given the context 'The inhibitory activity of the mAb 8D6 was demonstrated to be due to an inhibition of cell cycle progression of CD40 ligand-stimulated GC B cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [8d6; cd40]
<Options>: A: tnfrsf4 (homo sapiens) (aka tnf receptor superfamily member 4)
B: defa6 (homo sapiens) (aka defensin alpha 6)
C: cd40 molecule (oryctolagus cuniculus) (aka cd40 molecule)
D: cd40 (homo sapiens) (aka cd40 molecule)
E: cd40 (bos taurus) (aka cd40 molecule)
F: d8 (homo sapiens) (aka u... | [H; D] |
<Instruct>: Given the context 'In addition, the mAb 8D6 inhibits the growth of a lymphoma of GC origin, L3055, which depends on FDCs or HK cells for its growth.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [8d6]
<Options>: A: 8d6a (homo sapiens) (aka cd320 molecule)
B: 8d8.1 (drosophila melanogaster) (aka female sterile (1) nasrat)
C: 8d6 (mus musculus) (aka cd320 antigen)
D: d6 (homo sapiens) (aka atypical chemokine receptor 2)
E: eg:8d8.6 (drosophila melanogaster) (aka n(alpha)-acetyltransferase 30 a)
F: No... | [A] |
<Instruct>: Given the context 'An FDC signal molecule, 8D6 Ag, may be an important molecule to mediate this function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [8d6 ag]
<Options>: A: eg:8d8.6 (drosophila melanogaster) (aka n(alpha)-acetyltransferase 30 a)
B: ly-6d (homo sapiens) (aka lymphocyte antigen 6 family member d)
C: 8d6a (homo sapiens) (aka cd320 molecule)
D: tetraspanin 6 (homo sapiens) (aka tetraspanin 6)
E: ly6g6 (homo sapiens) (aka lymphocyte antigen 6... | [C] |
<Instruct>: Given the context 'Neutrophil polarity and locomotion are associated with surface redistribution of leukosialin (CD43), an antiadhesive membrane molecule.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [leukosialin; cd43]
<Options>: A: cd13 (homo sapiens) (aka alanyl aminopeptidase, membrane)
B: spn (homo sapiens) (sialophorin (homo sapiens)) (aka sialophorin)
C: sialophorin (sus scrofa) (aka sialophorin)
D: galn (homo sapiens) (aka galanin and gmap prepropeptide)
E: cd41 (homo sapiens) (aka integrin subu... | [B; B] |
<Instruct>: Given the context 'Neutrophil polarity and locomotion are associated with surface redistribution of leukosialin (CD43), an antiadhesive membrane molecule.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [leukosialin; cd43]
<Options>: A: granulysin (homo sapiens) (aka granulysin)
B: sialophorin (sus scrofa) (aka sialophorin)
C: glycoprotein a33 (homo sapiens) (aka glycoprotein a33)
D: gp3b (homo sapiens) (aka cd36 molecule (cd36 blood group))
E: leukosialin-like (rattus norvegicus) (aka leukosialin-like)
F:... | [G; G] |
<Instruct>: Given the context 'This study analyzed the behavior of an antiadhesive membrane molecule, CD43, in neutrophil polarization and locomotion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [cd43]
<Options>: A: gp3a (homo sapiens) (aka integrin subunit beta 3)
B: glycoprotein a33 (homo sapiens) (aka glycoprotein a33)
C: cd43 (homo sapiens) (aka sialophorin)
D: gp3b (homo sapiens) (aka cd36 molecule (cd36 blood group))
E: cd49c (homo sapiens) (aka integrin subunit alpha 3)
F: None of the above. | [C] |
<Instruct>: Given the context 'CD43 cross-linking by antibodies induced neutrophil locomotion, with CD43 molecules clustered at the uropod of polarized neutrophils.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [cd43]
<Options>: A: cd13 (homo sapiens) (aka alanyl aminopeptidase, membrane)
B: cd49c (homo sapiens) (aka integrin subunit alpha 3)
C: cd43 (homo sapiens) (aka sialophorin)
D: cd43 (xenopus tropicalis) (aka sialophorin)
E: glycoprotein a33 (homo sapiens) (aka glycoprotein a33)
F: None of the above. | [C] |
<Instruct>: Given the context 'In contrast, CD11b/CD18 cross-linking by antibodies did not affect either cell polarization or locomotion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd11b; cd18]
<Options>: A: cd118 (homo sapiens) (aka lif receptor subunit alpha)
B: cd11b (homo sapiens) (aka integrin subunit alpha m)
C: cd48 (homo sapiens) (aka cd48 molecule)
D: cd11b (rattus norvegicus) (aka integrin subunit alpha m)
E: slam family member 8 (homo sapiens) (aka slam family member 8)
F:... | [B; F] |
<Instruct>: Given the context 'In contrast, CD11b/CD18 cross-linking by antibodies did not affect either cell polarization or locomotion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd11b; cd18]
<Options>: A: cd11b (bos taurus) (aka integrin subunit alpha m)
B: cd118 (homo sapiens) (aka lif receptor subunit alpha)
C: cd48 (homo sapiens) (aka cd48 molecule)
D: cd11b (homo sapiens) (aka integrin subunit alpha m)
E: cd11a (mus musculus) (aka integrin alpha l)
F: itgax (mus musculus) (aka... | [D; G] |
<Instruct>: Given the context 'Stimulation of suspended or adherent neutrophils with chemotactic peptide results in cell polarization and locomotion and a concomitant redistribution of CD43 to the uropod.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [cd43]
<Options>: A: cd43 (homo sapiens) (aka sialophorin)
B: gp3a (homo sapiens) (aka integrin subunit beta 3)
C: cd46 (homo sapiens) (aka cd46 molecule)
D: cd41 (homo sapiens) (aka integrin subunit alpha 2b)
E: cd49c (homo sapiens) (aka integrin subunit alpha 3)
F: None of the above. | [A] |
<Instruct>: Given the context 'The study also investigated which actin-binding protein could be involved in CD43 lateral redistribution.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd43]
<Options>: A: cd46 (homo sapiens) (aka cd46 molecule)
B: gp3a (homo sapiens) (aka integrin subunit beta 3)
C: cd13 (homo sapiens) (aka alanyl aminopeptidase, membrane)
D: cd43 (homo sapiens) (aka sialophorin)
E: cd43 (xenopus tropicalis) (aka sialophorin)
F: None of the above. | [D] |
<Instruct>: Given the context 'alpha-Actinin and moesin are preferentially adsorbed on Sepharose beads bearing a recombinant CD43 intracellular domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [alpha-actinin; moesin]
<Options>: A: actinin (xenopus laevis) (actinin alpha 1 l homeolog (xenopus laevis)) (aka actinin alpha 1 l homeolog)
B: moesin s homeolog (xenopus laevis) (aka moesin s homeolog)
C: moesin pseudogene 1 (homo sapiens) (aka moesin pseudogene 1)
D: actinin alpha 2 (homo sapiens) (aka a... | [F; H] |
<Instruct>: Given the context 'alpha-Actinin and moesin are preferentially adsorbed on Sepharose beads bearing a recombinant CD43 intracellular domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [alpha-actinin; moesin]
<Options>: A: moesin pseudogene 1 (homo sapiens) (aka moesin pseudogene 1)
B: moesin (bos taurus) (aka moesin)
C: actinin alpha 2 (homo sapiens) (aka actinin alpha 2)
D: actinin alpha 3 (homo sapiens) (aka actinin alpha 3)
E: moesin (mus musculus) (aka moesin)
F: actinin alpha 1 (hom... | [F; J] |
<Instruct>: Given the context 'Analysis by immunofluorescence confocal microscopy shows a codistribution of moesin during CD43 lateral redistribution.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [moesin; cd43]
<Options>: A: moesin s homeolog (xenopus laevis) (aka moesin s homeolog)
B: cd43 (homo sapiens) (aka sialophorin)
C: cd46 (homo sapiens) (aka cd46 molecule)
D: glycoprotein a33 (homo sapiens) (aka glycoprotein a33)
E: moesin (bos taurus) (aka moesin)
F: cd43 (xenopus tropicalis) (aka sialopho... | [J; B] |
<Instruct>: Given the context 'Analysis by immunofluorescence confocal microscopy shows a codistribution of moesin during CD43 lateral redistribution.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [moesin; cd43]
<Options>: A: moesin pseudogene 1 (homo sapiens) (aka moesin pseudogene 1)
B: moesin (homo sapiens) (aka moesin)
C: cd43 (homo sapiens) (aka sialophorin)
D: gp3a (homo sapiens) (aka integrin subunit beta 3)
E: glycoprotein a33 (homo sapiens) (aka glycoprotein a33)
F: cd43 (xenopus tropicalis)... | [B; C] |
<Instruct>: Given the context 'By contrast, alpha-actinin is located at the leading edge, an area devoid of CD43.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha-actinin; cd43]
<Options>: A: gp3a (homo sapiens) (aka integrin subunit beta 3)
B: cd49c (homo sapiens) (aka integrin subunit alpha 3)
C: actinin alpha 1 (homo sapiens) (aka actinin alpha 1)
D: actinin-4 (homo sapiens) (aka actinin alpha 4)
E: actinin alpha 3 (homo sapiens) (aka actinin alpha 3)
F: gl... | [C; G] |
<Instruct>: Given the context 'By contrast, alpha-actinin is located at the leading edge, an area devoid of CD43.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha-actinin; cd43]
<Options>: A: actinin alpha 1 (homo sapiens) (aka actinin alpha 1)
B: actinin (xenopus laevis) (actinin alpha 1 s homeolog (xenopus laevis)) (aka actinin alpha 1 s homeolog)
C: actinin alpha 2 (homo sapiens) (aka actinin alpha 2)
D: actinin alpha 3 (homo sapiens) (aka actinin alpha 3)
... | [A; E] |
<Instruct>: Given the context 'These results shed new light on the role of CD43 membrane redistribution, which appears to be directly related to neutrophil polarity and locomotion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [cd43]
<Options>: A: cd43 (xenopus tropicalis) (aka sialophorin)
B: gp3a (homo sapiens) (aka integrin subunit beta 3)
C: cd43 (homo sapiens) (aka sialophorin)
D: cd46 molecule (homo sapiens) (aka cd46 molecule)
E: cd13 (homo sapiens) (aka alanyl aminopeptidase, membrane)
F: None of the above. | [C] |
<Instruct>: Given the context 'Here, we show that UDP-glucose, and some closely related molecules, potently activate the orphan G protein-coupled receptor KIAA0001 heterologously expressed in yeast or mammalian cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing... | <Mentions>: [kiaa0001]
<Options>: A: eg:100g10.1 (drosophila melanogaster) (aka uncharacterized protein)
B: cg6001 (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
C: heat repeat-containing protein 1 homolog (caenorhabditis elegans) (aka heat repeat-containing ... | [F] |
<Instruct>: Given the context 'Abnormal CAG repeat expansion in the alpha1A voltage-dependent calcium channel gene is associated with spinocerebellar ataxia type 6, an autosomal dominant cerebellar ataxia with a predominant loss of the Purkinje cell.', select the correct biomedical concept for each mention using the pr... | <Mentions>: [alpha1a voltage-dependent calcium channel]
<Options>: A: cacna1s (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 s)
B: cacna1c (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 c)
C: cms1a (homo sapiens) (cholinergic receptor nicotinic alpha 1 subunit (homo sapiens)) (aka ch... | [D] |
<Instruct>: Given the context 'Abnormal CAG repeat expansion in the alpha1A voltage-dependent calcium channel gene is associated with spinocerebellar ataxia type 6, an autosomal dominant cerebellar ataxia with a predominant loss of the Purkinje cell.', select the correct biomedical concept for each mention using the pr... | <Mentions>: [alpha1a voltage-dependent calcium channel]
<Options>: A: cacna1c (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 c)
B: cyclic nucleotide gated channel subunit alpha 1 (homo sapiens) (aka cyclic nucleotide gated channel subunit alpha 1)
C: cacna1s (homo sapiens) (aka calcium voltage-gated c... | [E] |
<Instruct>: Given the context 'A reverse transcriptase-polymerase chain reaction analysis of mRNA from mouse Purkinje cells revealed a predominant expression of the alpha1A channel lacking an asparagine-proline (NP) stretch in the domain IV (alpha1A(-NP)).', select the correct biomedical concept for each mention using ... | <Mentions>: [alpha1a]
<Options>: A: integrin subunit alpha 1 (homo sapiens) (aka integrin subunit alpha 1)
B: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
C: hemoglobin subunit alpha 1 (homo sapiens) (aka hemoglobin subunit alpha 1)
D: a1a (homo sapiens) (aka serpin family a member 1)
E: calcium voltage-gated chan... | [E] |
<Instruct>: Given the context 'Human alpha1A channels carrying various polyglutamine length with or without NP were expressed in HEK293 cells, and channel properties were compared using a whole-cell voltage clamp technique.', select the correct biomedical concept for each mention using the provided options. Answer by l... | <Mentions>: [alpha1a]
<Options>: A: amylase alpha 1a (homo sapiens) (aka amylase alpha 1a)
B: calcium voltage-gated channel subunit alpha1 a (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
C: calcium voltage-gated channel subunit alpha1 i (homo sapiens) (aka calcium voltage-gated channel subunit alp... | [B] |
<Instruct>: Given the context 'alpha1A(-NP), corresponding to P-type channel, with 24 and 28 polyglutamines found in patients showed the voltage dependence of inactivation shifting negatively by 6 and 11 mV, respectively, from the 13 polyglutamine control.', select the correct biomedical concept for each mention using ... | <Mentions>: [alpha1a]
<Options>: A: calcium voltage-gated channel subunit alpha1 i (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 i)
B: a1a (homo sapiens) (aka serpin family a member 1)
C: amylase alpha 1a (homo sapiens) (aka amylase alpha 1a)
D: hemoglobin subunit alpha 1 (homo sapiens) (aka hemoglob... | [E] |
<Instruct>: Given the context 'Contrarily, the alpha1A channel with NP (alpha1A(+NP)), corresponding to Q-type channel, with 28 polyglutamines exhibited a positive shift of 5 mV. These results suggest that altered function of alpha1A(-NP) may contribute to degeneration of Purkinje cells, which express predominantly alp... | <Mentions>: [alpha1a]
<Options>: A: alpha1 (homo sapiens) (aka adrenoceptor alpha 1d)
B: a1a (homo sapiens) (aka serpin family a member 1)
C: hemoglobin subunit alpha 1 (homo sapiens) (aka hemoglobin subunit alpha 1)
D: calcium voltage-gated channel subunit alpha1 a (homo sapiens) (aka calcium voltage-gated channel sub... | [D] |
<Instruct>: Given the context 'On the other hand, other types of neurons, expressing both alpha1A(-NP) and alpha1A(+NP), may survive because the positive shift of voltage-dependent inactivation of alpha1A(+NP) compensates Ca(2+) influx.', select the correct biomedical concept for each mention using the provided options... | <Mentions>: [alpha1a]
<Options>: A: calcium voltage-gated channel subunit alpha1 a (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
B: a1a (homo sapiens) (aka serpin family a member 1)
C: amylase alpha 1a (homo sapiens) (aka amylase alpha 1a)
D: tubulin alpha 1a (homo sapiens) (aka tubulin alpha 1a)
... | [A] |
<Instruct>: Given the context 'Structure, mapping and expression of the human gene encoding the homeodomain protein, SIX2.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [six2]
<Options>: A: six3 (homo sapiens) (aka six homeobox 3)
B: hairy and enhancer of split 5, gene 2 (xenopus tropicalis) (aka hairy and enhancer of split 5, gene 2)
C: six2 (gallus gallus) (aka six homeobox 2)
D: six2 (xenopus tropicalis) (aka six homeobox 2)
E: six2 (homo sapiens) (aka six homeobox 2)
F... | [E] |
<Instruct>: Given the context 'Vertebrate genes with sequence similarity to the Drosophila homeobox gene, sine oculis (so), constitute the SIX family.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [sine oculis; so]
<Options>: A: quo (danio rerio) (aka quattro b)
B: sok1 (homo sapiens) (aka serine/threonine kinase 25)
C: otx (drosophila melanogaster) (aka ocelliless)
D: sotos (homo sapiens) (aka nuclear receptor binding set domain protein 1)
E: otxa (xenopus laevis) (orthodenticle homeobox 2 s homeolo... | [G; G] |
<Instruct>: Given the context 'Vertebrate genes with sequence similarity to the Drosophila homeobox gene, sine oculis (so), constitute the SIX family.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [sine oculis; so]
<Options>: A: quo (homo sapiens) (aka kiaa1755)
B: sov (drosophila melanogaster) (aka small ovary)
C: soo (mus musculus) (aka sooty foot)
D: oculus-parvus (drosophila melanogaster) (aka oculus parvus)
E: micro-oculus (drosophila melanogaster) (aka micro-oculus)
F: sog (drosophila melanogas... | [I; I] |
<Instruct>: Given the context 'Vertebrate genes with sequence similarity to the Drosophila homeobox gene, sine oculis (so), constitute the SIX family.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [sine oculis; so]
<Options>: A: oculus-parvus (drosophila melanogaster) (aka oculus parvus)
B: soho (danio rerio) (aka h6 family homeobox 4)
C: micro-oculus (drosophila melanogaster) (aka micro-oculus)
D: soo (mus musculus) (aka sooty foot)
E: sog (drosophila melanogaster) (aka short gastrulation)
F: quo (h... | [I; I] |
<Instruct>: Given the context 'Mutations in three of these genes in man (SIX5, SIX6 and SIX3) are associated with severe phenotypes, and therefore, the cloning of other human genes from this family is of interest.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [six5; six6; six3]
<Options>: A: six homeobox 3 (homo sapiens) (aka six homeobox 3)
B: six homeobox 5 (homo sapiens) (aka six homeobox 5)
C: enhancer of seven in absentia 6 (drosophila melanogaster) (aka enhancer of seven in absentia 6)
D: hoxa6 (homo sapiens) (aka homeobox a6)
E: six3 (xenopus laevis) (six... | [B; H; A] |
<Instruct>: Given the context 'Mutations in three of these genes in man (SIX5, SIX6 and SIX3) are associated with severe phenotypes, and therefore, the cloning of other human genes from this family is of interest.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [six5; six6; six3]
<Options>: A: six5 (mus musculus) (aka sine oculis-related homeobox 5)
B: six6 (xenopus laevis) (aka six homeobox 6 l homeolog)
C: hairy and enhancer of split 3 (xenopus tropicalis) (aka hairy and enhancer of split 3)
D: six5 (danio rerio) (aka six homeobox 5)
E: six5 (homo sapiens) (aka ... | [L; F; K] |
<Instruct>: Given the context 'Mutations in three of these genes in man (SIX5, SIX6 and SIX3) are associated with severe phenotypes, and therefore, the cloning of other human genes from this family is of interest.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [six5; six6; six3]
<Options>: A: six6.1 (xenopus tropicalis) (aka six homeobox 6)
B: six5 (gallus gallus) (aka six homeobox 5)
C: hoxa6 (homo sapiens) (aka homeobox a6)
D: enhancer of seven in absentia 6 (drosophila melanogaster) (aka enhancer of seven in absentia 6)
E: six5 (homo sapiens) (aka six homeobox... | [E; G; I] |
<Instruct>: Given the context 'We have cloned and characterised the gene that encodes human SIX2, elucidated its gene structure and conducted expression studies in a range of tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [six2]
<Options>: A: six2 (mus musculus) (aka sine oculis-related homeobox 2)
B: six6 (homo sapiens) (aka six homeobox 6)
C: six3 (homo sapiens) (aka six homeobox 3)
D: six4 (homo sapiens) (aka six homeobox 4)
E: six2 (homo sapiens) (aka six homeobox 2)
F: None of the above. | [E] |
<Instruct>: Given the context 'We have cloned and characterised the gene that encodes human SIX2, elucidated its gene structure and conducted expression studies in a range of tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [six2]
<Options>: A: six2 (mus musculus) (aka sine oculis-related homeobox 2)
B: six3 (homo sapiens) (aka six homeobox 3)
C: six6 (homo sapiens) (aka six homeobox 6)
D: six4 (homo sapiens) (aka six homeobox 4)
E: None of the above. | [E] |
<Instruct>: Given the context 'SIX2 is widely expressed in the late first-trimester fetus, but has a limited range of expression sites in the adult.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [six2]
<Options>: A: six6 (homo sapiens) (aka six homeobox 6)
B: six2 (mus musculus) (aka sine oculis-related homeobox 2)
C: six3 (homo sapiens) (aka six homeobox 3)
D: six5 (homo sapiens) (aka six homeobox 5)
E: six homeobox 2 (homo sapiens) (aka six homeobox 2)
F: None of the above. | [E] |
<Instruct>: Given the context 'The expression pattern of SIX2 and its localisation to chromosome 2p15-p16 will be of use in assessing its candidacy in human developmental disorders.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ... | <Mentions>: [six2]
<Options>: A: six homeobox 2 (homo sapiens) (aka six homeobox 2)
B: six2 (gallus gallus) (aka six homeobox 2)
C: six4 (homo sapiens) (aka six homeobox 4)
D: six6 (homo sapiens) (aka six homeobox 6)
E: six2 (mus musculus) (aka sine oculis-related homeobox 2)
F: None of the above. | [A] |
<Instruct>: Given the context 'Enhanced growth of MCF-7 breast cancer cells overexpressing parathyroid hormone-related peptide.
PTH-related peptide (PTHrP) is a secreted protein produced by breast cancer cells both in vivo and in vitro.', select the correct biomedical concept for each mention using the provided options... | <Mentions>: [parathyroid hormone-related peptide; pth-related peptide; pthrp]
<Options>: A: pro-trh (homo sapiens) (aka thyrotropin releasing hormone)
B: hptp (homo sapiens) (aka protein tyrosine phosphatase receptor type d)
C: parathyroid hormone-like hormone (rattus norvegicus) (aka parathyroid hormone-like hormone)
... | [D; D; D] |
<Instruct>: Given the context 'Enhanced growth of MCF-7 breast cancer cells overexpressing parathyroid hormone-related peptide.
PTH-related peptide (PTHrP) is a secreted protein produced by breast cancer cells both in vivo and in vitro.', select the correct biomedical concept for each mention using the provided options... | <Mentions>: [parathyroid hormone-related peptide; pth-related peptide; pthrp]
<Options>: A: parathyroid hormone-like hormone (rattus norvegicus) (aka parathyroid hormone-like hormone)
B: pthrp (xenopus laevis) (aka parathyroid hormone-like hormone l homeolog)
C: pth promoter region (homo sapiens) (aka pth promoter regi... | [I; I; I] |
<Instruct>: Given the context 'Enhanced growth of MCF-7 breast cancer cells overexpressing parathyroid hormone-related peptide.
PTH-related peptide (PTHrP) is a secreted protein produced by breast cancer cells both in vivo and in vitro.', select the correct biomedical concept for each mention using the provided options... | <Mentions>: [parathyroid hormone-related peptide; pth-related peptide; pthrp]
<Options>: A: pro-trh (homo sapiens) (aka thyrotropin releasing hormone)
B: hptp (homo sapiens) (aka protein tyrosine phosphatase receptor type d)
C: parathyroid hormone like hormone (homo sapiens) (aka parathyroid hormone like hormone)
D: pa... | [C; C; C] |
<Instruct>: Given the context 'Because of its structural similarity to PTH at the amino terminus, the two proteins interact with a common cell surface receptor, the PTH/PTHrP receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [pth; pth/pthrp receptor]
<Options>: A: hptp (homo sapiens) (aka protein tyrosine phosphatase receptor type d)
B: pth (homo sapiens) (parathyroid hormone (homo sapiens)) (aka parathyroid hormone)
C: thyrotropin releasing hormone receptor (homo sapiens) (aka thyrotropin releasing hormone receptor)
D: pth pro... | [B; H] |
<Instruct>: Given the context 'Because of its structural similarity to PTH at the amino terminus, the two proteins interact with a common cell surface receptor, the PTH/PTHrP receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [pth; pth/pthrp receptor]
<Options>: A: parathyroid hormone 1 receptor (bos taurus) (aka parathyroid hormone 1 receptor)
B: hptp (homo sapiens) (aka protein tyrosine phosphatase receptor type d)
C: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
D: hpt (homo sapiens) (aka hypoparathyroidism)
E: ... | [E; I] |
<Instruct>: Given the context 'When overproduced by tumor cells, PTHrP enters the circulation, giving rise to the common paraneoplastic syndrome of humoral hypercalcemia of malignancy.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [pthrp]
<Options>: A: pthrp (bos taurus) (aka parathyroid hormone like hormone)
B: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
C: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
D: pth promoter region (homo sapiens) (aka pth promoter region)
E: pthr (homo sapiens) (parathyroid h... | [E] |
<Instruct>: Given the context 'Although initially discovered in malignancies, PTHrP is now known to be produced by most cells and tissues in the body.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [pthrp]
<Options>: A: parathyroid hormone like hormone (homo sapiens) (aka parathyroid hormone like hormone)
B: pthrp (xenopus laevis) (aka parathyroid hormone-like hormone l homeolog)
C: pth promoter region (homo sapiens) (aka pth promoter region)
D: pthrp (bos taurus) (aka parathyroid hormone like hormone... | [A] |
<Instruct>: Given the context 'It acts as an autocrine and paracrine mediator of cell proliferation and differentiation, effects which are mediated via the PTH/PTHrP receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [pth/pthrp receptor]
<Options>: A: parathyroid hormone 2 receptor (homo sapiens) (aka parathyroid hormone 2 receptor)
B: pthr1 (homo sapiens) (aka parathyroid hormone 1 receptor)
C: trhr (homo sapiens) (aka thyrotropin releasing hormone receptor)
D: parathyroid hormone 1 receptor (bos taurus) (aka parathyro... | [B] |
<Instruct>: Given the context 'Recent evidence also has shown that, directly after translation, PTHrP is able to enter the nucleus and/or nucleolus and influence cell cycle progression and apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opti... | <Mentions>: [pthrp]
<Options>: A: pth promoter region (homo sapiens) (aka pth promoter region)
B: pthr1 (homo sapiens) (aka parathyroid hormone 1 receptor)
C: pthrp (homo sapiens) (aka parathyroid hormone like hormone)
D: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
E: pthrp (xenopus laevis) (aka parath... | [C] |
<Instruct>: Given the context 'In this study, we have either overproduced PTHrP or inhibited endogenous PTHrP production in the breast cancer cell line, MCF-7.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [pthrp]
<Options>: A: pthrp (xenopus laevis) (aka parathyroid hormone-like hormone l homeolog)
B: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
C: pth promoter region (homo sapiens) (aka pth promoter region)
D: pthr (homo sapiens) (parathyroid hormone like hormone (homo sapiens)) (aka parathyr... | [D] |
<Instruct>: Given the context 'In this study, we have either overproduced PTHrP or inhibited endogenous PTHrP production in the breast cancer cell line, MCF-7.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [pthrp]
<Options>: A: pth promoter region (homo sapiens) (aka pth promoter region)
B: pthrp (xenopus laevis) (aka parathyroid hormone-like hormone l homeolog)
C: pthrp (bos taurus) (aka parathyroid hormone like hormone)
D: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
E: None of the above. | [E] |
<Instruct>: Given the context 'Overexpression of PTHrP was associated with an increase in mitogenesis, whereas inhibiting endogenous PTHrP production resulted in decreased cell proliferation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one... | <Mentions>: [pthrp]
<Options>: A: parathyroid hormone like hormone (homo sapiens) (aka parathyroid hormone like hormone)
B: pthr1 (homo sapiens) (aka parathyroid hormone 1 receptor)
C: pth promoter region (homo sapiens) (aka pth promoter region)
D: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
E: pthrp (x... | [A] |
<Instruct>: Given the context 'In contrast, PTHrP interaction with the cell surface PTH/PTHrP receptor resulted in decreased cell proliferation in the same cell line.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [pthrp; pth/pthrp receptor]
<Options>: A: pthr2 (homo sapiens) (aka parathyroid hormone 2 receptor)
B: thyrotropin releasing hormone receptor (homo sapiens) (aka thyrotropin releasing hormone receptor)
C: parathyroid hormone like hormone (homo sapiens) (aka parathyroid hormone like hormone)
D: pthr1 (homo s... | [C; I] |
<Instruct>: Given the context 'In contrast, PTHrP interaction with the cell surface PTH/PTHrP receptor resulted in decreased cell proliferation in the same cell line.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [pthrp; pth/pthrp receptor]
<Options>: A: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
B: parathyroid hormone 1 receptor (bos taurus) (aka parathyroid hormone 1 receptor)
C: pth promoter region (homo sapiens) (aka pth promoter region)
D: pthr (homo sapiens) (parathyroid hormone like hormone ... | [D; I] |
<Instruct>: Given the context 'This latter effect is dependent on interaction with the receptor, in that exogenously added PTHrP moieties known not to interact with the receptor had no effect on cell growth.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [pthrp]
<Options>: A: pthr1 (homo sapiens) (aka parathyroid hormone 1 receptor)
B: pthrp (homo sapiens) (aka parathyroid hormone like hormone)
C: pthrp (xenopus laevis) (aka parathyroid hormone-like hormone l homeolog)
D: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
E: pthrp (bos taurus) (ak... | [B] |
<Instruct>: Given the context 'Furthermore, neutralization of added peptide with an anti-PTHrP antiserum completely abolished the growth inhibitory effects.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [pthrp]
<Options>: A: pthrp (bos taurus) (aka parathyroid hormone like hormone)
B: pth promoter region (homo sapiens) (aka pth promoter region)
C: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
D: pthr (homo sapiens) (parathyroid hormone like hormone (homo sapiens)) (aka parathyroid hormone li... | [D] |
<Instruct>: Given the context 'In contrast, this antibody has no effect on the increased proliferation rate of the MCF-7 transfectants that overexpress PTHrP, compared with control cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [pthrp]
<Options>: A: pthr (homo sapiens) (parathyroid hormone like hormone (homo sapiens)) (aka parathyroid hormone like hormone)
B: pthrp (bos taurus) (aka parathyroid hormone like hormone)
C: parathyroid hormone (homo sapiens) (aka parathyroid hormone)
D: pth1 (homo sapiens) (aka peptidyl-trna hydrolase ... | [A] |
<Instruct>: Given the context 'The net effect of autocrine/paracrine and intracrine effects of PTHrP in MCF-7 cells overproducing the peptide is accelerated cell growth.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [pthrp]
<Options>: A: pthr (homo sapiens) (parathyroid hormone like hormone (homo sapiens)) (aka parathyroid hormone like hormone)
B: pth1 (homo sapiens) (aka peptidyl-trna hydrolase 1 homolog)
C: pthr (homo sapiens) (parathyroid hormone 1 receptor (homo sapiens)) (aka parathyroid hormone 1 receptor)
D: pth... | [A] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.