instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Vasopressin exposure induced increases in water permeability and the absolute labeling density of AQP-CD in the APM.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vasopressin; aqp-cd]
<Options>: A: avp (homo sapiens) (arginine vasopressin (homo sapiens)) (aka arginine vasopressin)
B: aqp-cd (xenopus tropicalis) (aka aquaporin 2)
C: vasopressin (xenopus laevis) (arginine vasopressin s homeolog (xenopus laevis)) (aka arginine vasopressin s homeolog)
D: aqp-cd (oryctolagus cuniculus) (aka aquaporin 2)
E: arginine vasopressin (rattus norvegicus) (aka arginine vasopressin)
F: vasopressin (sus scrofa) (aka vasopressin)
G: aqpcd (xenopus laevis) (aquaporin 2 s homeolog (xenopus laevis)) (aka aquaporin 2 s homeolog)
H: vasopressin (xenopus laevis) (arginine vasopressin l homeolog (xenopus laevis)) (aka arginine vasopressin l homeolog)
I: aqp-cd (mus musculus) (aka aquaporin 2)
J: None of the above. | [A; J] |
<Instruct>: Given the context 'Furthermore, in response to vasopressin withdrawal, AQP-CD labeling density in the APM and the APM:IV labeling ratio decreased in parallel to a measured decrease in osmotic water permeability.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vasopressin; aqp-cd]
<Options>: A: arginine vasopressin (homo sapiens) (aka arginine vasopressin)
B: avp (rattus norvegicus) (aka arginine vasopressin)
C: aqp-cd (xenopus laevis) (aquaporin 2 s homeolog (xenopus laevis)) (aka aquaporin 2 s homeolog)
D: aqp-cd (xenopus laevis) (aquaporin 2 l homeolog (xenopus laevis)) (aka aquaporin 2 l homeolog)
E: aqp-cd (oryctolagus cuniculus) (aka aquaporin 2)
F: aqpcd (xenopus tropicalis) (aka aquaporin 2)
G: aqp-cd (homo sapiens) (aka aquaporin 2)
H: vasopressin (xenopus laevis) (arginine vasopressin l homeolog (xenopus laevis)) (aka arginine vasopressin l homeolog)
I: vasopressin (sus scrofa) (aka vasopressin)
J: arginine vasopressin (xenopus tropicalis) (aka arginine vasopressin)
K: None of the above. | [A; G] |
<Instruct>: Given the context 'Furthermore, in response to vasopressin withdrawal, AQP-CD labeling density in the APM and the APM:IV labeling ratio decreased in parallel to a measured decrease in osmotic water permeability.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vasopressin; aqp-cd]
<Options>: A: aqp-cd (homo sapiens) (aka aquaporin 2)
B: vp (homo sapiens) (arginine vasopressin (homo sapiens)) (aka arginine vasopressin)
C: aqpcd (xenopus tropicalis) (aka aquaporin 2)
D: arginine vasopressin (xenopus tropicalis) (aka arginine vasopressin)
E: aqp-2 (oryctolagus cuniculus) (aka aquaporin 2)
F: aqp-cd (xenopus laevis) (aquaporin 2 s homeolog (xenopus laevis)) (aka aquaporin 2 s homeolog)
G: vasopressin (sus scrofa) (aka vasopressin)
H: aqpcd (xenopus laevis) (aquaporin 2 l homeolog (xenopus laevis)) (aka aquaporin 2 l homeolog)
I: avp (rattus norvegicus) (aka arginine vasopressin)
J: vasotocin (xenopus laevis) (arginine vasopressin s homeolog (xenopus laevis)) (aka arginine vasopressin s homeolog)
K: None of the above. | [B; A] |
<Instruct>: Given the context 'We conclude that vasopressin increases the water permeability of collecting duct cells by inducing a reversible translocation of AQP-CD water channels from IVs to the APM.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vasopressin; aqp-cd]
<Options>: A: aqp-cd (oryctolagus cuniculus) (aka aquaporin 2)
B: arginine vasopressin (rattus norvegicus) (aka arginine vasopressin)
C: vasopressin (xenopus laevis) (arginine vasopressin s homeolog (xenopus laevis)) (aka arginine vasopressin s homeolog)
D: aqp-cd (xenopus tropicalis) (aka aquaporin 2)
E: vasopressin (sus scrofa) (aka vasopressin)
F: vasopressin (xenopus laevis) (arginine vasopressin l homeolog (xenopus laevis)) (aka arginine vasopressin l homeolog)
G: aqp-cd (xenopus laevis) (aquaporin 2 l homeolog (xenopus laevis)) (aka aquaporin 2 l homeolog)
H: aqp-cd (homo sapiens) (aka aquaporin 2)
I: aqp-cd (mus musculus) (aka aquaporin 2)
J: vp (homo sapiens) (arginine vasopressin (homo sapiens)) (aka arginine vasopressin)
K: None of the above. | [J; H] |
<Instruct>: Given the context 'We conclude that vasopressin increases the water permeability of collecting duct cells by inducing a reversible translocation of AQP-CD water channels from IVs to the APM.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vasopressin; aqp-cd]
<Options>: A: aqpcd (xenopus laevis) (aquaporin 2 s homeolog (xenopus laevis)) (aka aquaporin 2 s homeolog)
B: aqpcd (xenopus laevis) (aquaporin 2 l homeolog (xenopus laevis)) (aka aquaporin 2 l homeolog)
C: vasopressin (xenopus laevis) (arginine vasopressin l homeolog (xenopus laevis)) (aka arginine vasopressin l homeolog)
D: aqpcd (xenopus tropicalis) (aka aquaporin 2)
E: aqp-cd (homo sapiens) (aka aquaporin 2)
F: arginine vasopressin (rattus norvegicus) (aka arginine vasopressin)
G: vasopressin (sus scrofa) (aka vasopressin)
H: vasotocin (xenopus laevis) (arginine vasopressin s homeolog (xenopus laevis)) (aka arginine vasopressin s homeolog)
I: aqp-cd (mus musculus) (aka aquaporin 2)
J: avp (homo sapiens) (arginine vasopressin (homo sapiens)) (aka arginine vasopressin)
K: None of the above. | [J; E] |
<Instruct>: Given the context 'Functional expression and pharmacological characterization of the human EAA4 (GluR6) glutamate receptor: a kainate selective channel subunit.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eaa4; glur6]
<Options>: A: eaat4 (homo sapiens) (aka solute carrier family 1 member 6)
B: ea6 (homo sapiens) (aka solute carrier family 1 member 3)
C: glutamate receptor 2.6 (glycine max) (aka glutamate receptor 2.6)
D: eaa4 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 2)
E: eap4 (homo sapiens) (aka exosome component 6)
F: glua4 (homo sapiens) (aka glutamate ionotropic receptor ampa type subunit 4)
G: grg6 (homo sapiens) (aka tle family member 6, subcortical maternal complex member)
H: glur-6 (mus musculus) (aka glutamate receptor, ionotropic, kainate 2 (beta 2))
I: glur-6 (xenopus laevis) (aka glutamate receptor, ionotropic, kainate 2 s homeolog)
J: None of the above. | [D; D] |
<Instruct>: Given the context 'Functional expression and pharmacological characterization of the human EAA4 (GluR6) glutamate receptor: a kainate selective channel subunit.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eaa4; glur6]
<Options>: A: glua4 (homo sapiens) (aka glutamate ionotropic receptor ampa type subunit 4)
B: grg6 (homo sapiens) (aka tle family member 6, subcortical maternal complex member)
C: glur-6 (mus musculus) (aka glutamate receptor, ionotropic, kainate 2 (beta 2))
D: ea6 (homo sapiens) (aka solute carrier family 1 member 3)
E: eap4 (homo sapiens) (aka exosome component 6)
F: eaat4 (homo sapiens) (aka solute carrier family 1 member 6)
G: glutamate receptor 2.6 (glycine max) (aka glutamate receptor 2.6)
H: glur-6 (xenopus laevis) (aka glutamate receptor, ionotropic, kainate 2 s homeolog)
I: None of the above. | [I; I] |
<Instruct>: Given the context 'Functional expression and pharmacological characterization of the human EAA4 (GluR6) glutamate receptor: a kainate selective channel subunit.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eaa4; glur6]
<Options>: A: eaa4 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 2)
B: ea8 (homo sapiens) (aka episodic ataxia, type 8)
C: glur6 (rattus norvegicus) (aka glutamate ionotropic receptor kainate type subunit 2)
D: eaf4 (homo sapiens) (aka inhibitor of growth family member 3)
E: glua4 (homo sapiens) (aka glutamate ionotropic receptor ampa type subunit 4)
F: glur-6 (xenopus laevis) (aka glutamate receptor, ionotropic, kainate 2 s homeolog)
G: glutamate receptor 2.6 (glycine max) (aka glutamate receptor 2.6)
H: eaat4 (homo sapiens) (aka solute carrier family 1 member 6)
I: mglu6 (homo sapiens) (aka glutamate metabotropic receptor 6)
J: None of the above. | [A; A] |
<Instruct>: Given the context 'A cDNA encoding an ionotropic glutamate receptor subunit protein humEAA4 (GluR6), has been cloned from a human fetal brain library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [humeaa4; glur6]
<Options>: A: hypertension, essential, susceptibility to, 4 (homo sapiens) (aka hypertension, essential, susceptibility to, 4)
B: enhancer of seven in absentia 4 (drosophila melanogaster) (aka enhancer of seven in absentia 4)
C: glur8 (homo sapiens) (aka glutamate metabotropic receptor 8)
D: glur6 (xenopus tropicalis) (aka glutamate receptor, ionotropic, kainate 2)
E: mglu6 (homo sapiens) (aka glutamate metabotropic receptor 6)
F: eaa4 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 2)
G: hae4 (homo sapiens) (aka plasminogen)
H: glur6 (rattus norvegicus) (aka glutamate ionotropic receptor kainate type subunit 2)
I: ele4 (homo sapiens) (aka regulatory region in intron 4 of pax6)
J: None of the above. | [F; F] |
<Instruct>: Given the context 'A cDNA encoding an ionotropic glutamate receptor subunit protein humEAA4 (GluR6), has been cloned from a human fetal brain library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [humeaa4; glur6]
<Options>: A: mglu6 (homo sapiens) (aka glutamate metabotropic receptor 6)
B: grg6 (homo sapiens) (aka tle family member 6, subcortical maternal complex member)
C: ela4 (homo sapiens) (aka chymotrypsin c)
D: glur6 (xenopus tropicalis) (aka glutamate receptor, ionotropic, kainate 2)
E: esa4 (homo sapiens) (aka esterase a4)
F: glur-6 (mus musculus) (aka glutamate receptor, ionotropic, kainate 2 (beta 2))
G: eca4 (homo sapiens) (aka gamma-aminobutyric acid type a receptor subunit alpha1)
H: eaa4 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 2)
I: saa4 (homo sapiens) (aka serum amyloid a4, constitutive)
J: None of the above. | [H; H] |
<Instruct>: Given the context 'We have successfully established cell lines stably expressing humEAA4 in HEK-293 cells This is the first report of the establishment of stable cell lines expressing a glutamate receptor channel.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [humeaa4]
<Options>: A: hypertension, essential, susceptibility to, 4 (homo sapiens) (aka hypertension, essential, susceptibility to, 4)
B: ele4 (homo sapiens) (aka regulatory region in intron 4 of pax6)
C: eaa4 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 2)
D: esa4 (homo sapiens) (aka esterase a4)
E: ela4 (homo sapiens) (aka chymotrypsin c)
F: None of the above. | [C] |
<Instruct>: Given the context 'The relative potency of compounds for displacing [3H]-kainate binding to humEAA4 receptors expressed in COS or HEK-293 cells is domoate > kainate > quisqualate > 6-cyano-7-nitroquinoxaline-2,3-dione > L-glutamate = 6,7- dinitroquinoxaline-2,3-dione > dihydrokainate.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [humeaa4]
<Options>: A: esa4 (homo sapiens) (aka esterase a4)
B: ele4 (homo sapiens) (aka regulatory region in intron 4 of pax6)
C: eaa4 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 2)
D: ela4 (homo sapiens) (aka chymotrypsin c)
E: help4 (homo sapiens) (aka elongator acetyltransferase complex subunit 4)
F: None of the above. | [C] |
<Instruct>: Given the context 'Applications of kainate, glutamate, and domoate but not AMPA evoked rapidly desensitizing currents in cells expressing homo-oligomeric humEAA4 in a concentration dependent manner.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [humeaa4]
<Options>: A: help4 (homo sapiens) (aka elongator acetyltransferase complex subunit 4)
B: enhancer of seven in absentia 4 (drosophila melanogaster) (aka enhancer of seven in absentia 4)
C: hae4 (homo sapiens) (aka plasminogen)
D: hypertension, essential, susceptibility to, 4 (homo sapiens) (aka hypertension, essential, susceptibility to, 4)
E: eaa4 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 2)
F: None of the above. | [E] |
<Instruct>: Given the context 'Although AMPA did not itself activate humEAA4 receptors it did reduce, to a limited extent, kainate-evoked responses.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [humeaa4]
<Options>: A: ela4 (homo sapiens) (aka chymotrypsin c)
B: help4 (homo sapiens) (aka elongator acetyltransferase complex subunit 4)
C: eaa4 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 2)
D: hypertension, essential, susceptibility to, 4 (homo sapiens) (aka hypertension, essential, susceptibility to, 4)
E: saa4 (homo sapiens) (aka serum amyloid a4, constitutive)
F: None of the above. | [C] |
<Instruct>: Given the context 'Although AMPA did not itself activate humEAA4 receptors it did reduce, to a limited extent, kainate-evoked responses.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [humeaa4]
<Options>: A: hypertension, essential, susceptibility to, 4 (homo sapiens) (aka hypertension, essential, susceptibility to, 4)
B: ela4 (homo sapiens) (aka chymotrypsin c)
C: help4 (homo sapiens) (aka elongator acetyltransferase complex subunit 4)
D: saa4 (homo sapiens) (aka serum amyloid a4, constitutive)
E: None of the above. | [E] |
<Instruct>: Given the context 'To date this effect has not been demonstrated with rat GluR6.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [glur6]
<Options>: A: glur6 (rattus norvegicus) (aka glutamate ionotropic receptor kainate type subunit 2)
B: glur6 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 2)
C: grg6 (homo sapiens) (aka tle family member 6, subcortical maternal complex member)
D: glutamate receptor 2.6 (glycine max) (aka glutamate receptor 2.6)
E: glur-6 (xenopus laevis) (aka glutamate receptor, ionotropic, kainate 2 s homeolog)
F: None of the above. | [B] |
<Instruct>: Given the context 'Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [src-like adapter; eck]
<Options>: A: sla (homo sapiens) (src like adaptor (homo sapiens)) (aka src like adaptor)
B: src like adaptor 2 (sus scrofa) (aka src like adaptor 2)
C: eck (homo sapiens) (aka eph receptor a2)
D: cek2 (homo sapiens) (aka fibroblast growth factor receptor 3)
E: src-like adaptor (mus musculus) (aka src-like adaptor)
F: eek (homo sapiens) (aka eph receptor a8)
G: srcl (homo sapiens) (aka collectin subfamily member 12)
H: ehk-2 (homo sapiens) (aka eph receptor a6)
I: etk (escherichia coli str. k-12 substr. mg1655) (aka protein-tyrosine kinase etk)
J: srcap (homo sapiens) (aka snf2 related crebbp activator protein)
K: None of the above. | [A; C] |
<Instruct>: Given the context 'Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [src-like adapter; eck]
<Options>: A: ecfk (escherichia coli str. k-12 substr. mg1655) (aka outer membrane protein assembly factor bama)
B: ehk-2 (homo sapiens) (aka eph receptor a6)
C: srcl (homo sapiens) (aka collectin subfamily member 12)
D: sla (homo sapiens) (src like adaptor (homo sapiens)) (aka src like adaptor)
E: eck (homo sapiens) (aka eph receptor a2)
F: src like adaptor 2 (homo sapiens) (aka src like adaptor 2)
G: etk (escherichia coli str. k-12 substr. mg1655) (aka protein-tyrosine kinase etk)
H: src like adaptor (xenopus tropicalis) (aka src like adaptor)
I: srcap (homo sapiens) (aka snf2 related crebbp activator protein)
J: eck (mus musculus) (aka eph receptor a2)
K: None of the above. | [D; E] |
<Instruct>: Given the context 'Using a yeast two-hybrid screen to identify molecules that interact with the cytoplasmic domain of Eck, it was previously shown that activated Eck RPTK bound to and stimulated phosphatidylinositol 3-kinase (Pandey, A., Lazar, D.F., Saltiel, A. R., and Dixit, V.M. (1994) J. Biol.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eck]
<Options>: A: eek (homo sapiens) (aka eph receptor a8)
B: cek7 (homo sapiens) (aka eph receptor a5)
C: eck (mus musculus) (aka eph receptor a2)
D: cek2 (homo sapiens) (aka fibroblast growth factor receptor 3)
E: eck (homo sapiens) (aka eph receptor a2)
F: None of the above. | [E] |
<Instruct>: Given the context 'Hence, this protein was designated SLAP for Src-like adapter protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [slap; src-like adapter]
<Options>: A: srcl (homo sapiens) (aka collectin subfamily member 12)
B: slap (homo sapiens) (sarcolemma associated protein (homo sapiens)) (aka sarcolemma associated protein)
C: slan (homo sapiens) (aka secis binding protein 2 like)
D: slat (homo sapiens) (aka def6 guanine nucleotide exchange factor)
E: sla (homo sapiens) (src like adaptor (homo sapiens)) (aka src like adaptor)
F: src like adaptor (xenopus tropicalis) (aka src like adaptor)
G: slap-2 (homo sapiens) (aka src like adaptor 2)
H: src like adaptor 2 (homo sapiens) (aka src like adaptor 2)
I: sla (sus scrofa) (src like adaptor (sus scrofa)) (aka src like adaptor)
J: None of the above. | [E; E] |
<Instruct>: Given the context 'Hence, this protein was designated SLAP for Src-like adapter protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [slap; src-like adapter]
<Options>: A: sla (sus scrofa) (src like adaptor (sus scrofa)) (aka src like adaptor)
B: sla1p (homo sapiens) (aka src like adaptor)
C: src-like adaptor (mus musculus) (aka src-like adaptor)
D: src like adaptor 2 (sus scrofa) (aka src like adaptor 2)
E: slan (homo sapiens) (aka secis binding protein 2 like)
F: sla/lp (homo sapiens) (aka sep (o-phosphoserine) trna:sec (selenocysteine) trna synthase)
G: src like adaptor (xenopus tropicalis) (aka src like adaptor)
H: slap (homo sapiens) (sarcolemma associated protein (homo sapiens)) (aka sarcolemma associated protein)
I: src like adaptor (sus scrofa) (aka src like adaptor)
J: None of the above. | [B; B] |
<Instruct>: Given the context 'Hence, this protein was designated SLAP for Src-like adapter protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [slap; src-like adapter]
<Options>: A: sla (sus scrofa) (src like adaptor (sus scrofa)) (aka src like adaptor)
B: src like adaptor 2 (sus scrofa) (aka src like adaptor 2)
C: slap (homo sapiens) (sarcolemma associated protein (homo sapiens)) (aka sarcolemma associated protein)
D: slan (homo sapiens) (aka secis binding protein 2 like)
E: sla/lp (homo sapiens) (aka sep (o-phosphoserine) trna:sec (selenocysteine) trna synthase)
F: src like adaptor (xenopus tropicalis) (aka src like adaptor)
G: src like adaptor (sus scrofa) (aka src like adaptor)
H: src-like adaptor (mus musculus) (aka src-like adaptor)
I: None of the above. | [I; I] |
<Instruct>: Given the context 'Using glutathione S-transferase fusion Proteins, it was demonstrated that SLAP bound to activated Eck receptor tyrosine kinase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [slap; eck]
<Options>: A: cek2 (homo sapiens) (aka fibroblast growth factor receptor 3)
B: cek (homo sapiens) (aka fibroblast growth factor receptor 1)
C: slap2 (homo sapiens) (aka src like adaptor 2)
D: cek7 (homo sapiens) (aka eph receptor a5)
E: slan (homo sapiens) (aka secis binding protein 2 like)
F: ehk-2 (homo sapiens) (aka eph receptor a6)
G: sla (sus scrofa) (src like adaptor (sus scrofa)) (aka src like adaptor)
H: sla- (sus scrofa) (aka mhc class i antigen 1)
I: eck (homo sapiens) (aka eph receptor a2)
J: sla1p (homo sapiens) (aka src like adaptor)
K: None of the above. | [J; I] |
<Instruct>: Given the context 'Using glutathione S-transferase fusion Proteins, it was demonstrated that SLAP bound to activated Eck receptor tyrosine kinase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [slap; eck]
<Options>: A: cek2 (homo sapiens) (aka fibroblast growth factor receptor 3)
B: slan (homo sapiens) (aka secis binding protein 2 like)
C: sla (homo sapiens) (src like adaptor (homo sapiens)) (aka src like adaptor)
D: slat (homo sapiens) (aka def6 guanine nucleotide exchange factor)
E: sla/lp (homo sapiens) (aka sep (o-phosphoserine) trna:sec (selenocysteine) trna synthase)
F: ecfk (escherichia coli str. k-12 substr. mg1655) (aka outer membrane protein assembly factor bama)
G: ek (homo sapiens) (choline kinase beta (homo sapiens)) (aka choline kinase beta)
H: eek (homo sapiens) (aka eph receptor a8)
I: slap-2 (homo sapiens) (aka src like adaptor 2)
J: eck (homo sapiens) (aka eph receptor a2)
K: None of the above. | [C; J] |
<Instruct>: Given the context 'Therefore, SLAP is a novel candidate downstream signaling intermediate and the first member of the Src family that resembles an adapter molecule.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [slap]
<Options>: A: sla1p (homo sapiens) (aka src like adaptor)
B: slan (homo sapiens) (aka secis binding protein 2 like)
C: slap (homo sapiens) (sarcolemma associated protein (homo sapiens)) (aka sarcolemma associated protein)
D: slap-2 (homo sapiens) (aka src like adaptor 2)
E: sla/lp (homo sapiens) (aka sep (o-phosphoserine) trna:sec (selenocysteine) trna synthase)
F: None of the above. | [A] |
<Instruct>: Given the context 'Two proteins with seven transmembrane-spanning domains typical of guanosine-nucleotide-binding-protein-coupled receptors have been identified as cannabinoid receptors; the central cannabinoid receptor, CB1, and the peripheral cannabinoid receptor, CB2, initially described in rat brain and spleen, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb1; cb2]
<Options>: A: cb1r (mus musculus) (aka cannabinoid receptor 1)
B: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
C: cb2 (homo sapiens) (aka cannabinoid receptor 2)
D: cb1 (rattus norvegicus) (aka cannabinoid receptor 1)
E: cmkbr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
F: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
G: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
H: cb1r (homo sapiens) (aka cannabinoid receptor 1)
I: None of the above. | [H; C] |
<Instruct>: Given the context 'Two proteins with seven transmembrane-spanning domains typical of guanosine-nucleotide-binding-protein-coupled receptors have been identified as cannabinoid receptors; the central cannabinoid receptor, CB1, and the peripheral cannabinoid receptor, CB2, initially described in rat brain and spleen, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb1; cb2]
<Options>: A: cb1a (mus musculus) (aka cannabinoid receptor 1)
B: cb1r (rattus norvegicus) (aka cannabinoid receptor 1)
C: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2)
D: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
E: cb1a (homo sapiens) (aka cannabinoid receptor 1)
F: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
G: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
H: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
I: None of the above. | [E; C] |
<Instruct>: Given the context 'Here, we report the distribution patterns for both CB1 and CB2 transcripts in human immune cells and in several human tissues, as analysed using a highly sensitive and quantitative PCR-based method.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb1; cb2]
<Options>: A: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
B: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
C: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
D: cb1a (mus musculus) (aka cannabinoid receptor 1)
E: cb2 (homo sapiens) (aka cannabinoid receptor 2)
F: cb1a (homo sapiens) (aka cannabinoid receptor 1)
G: cb1r (rattus norvegicus) (aka cannabinoid receptor 1)
H: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
I: None of the above. | [F; E] |
<Instruct>: Given the context 'Here, we report the distribution patterns for both CB1 and CB2 transcripts in human immune cells and in several human tissues, as analysed using a highly sensitive and quantitative PCR-based method.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb1; cb2]
<Options>: A: ckr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
B: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
C: cb1r (rattus norvegicus) (aka cannabinoid receptor 1)
D: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
E: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
F: cb1a (homo sapiens) (aka cannabinoid receptor 1)
G: cb1a (mus musculus) (aka cannabinoid receptor 1)
H: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2)
I: None of the above. | [F; H] |
<Instruct>: Given the context 'CB1 was mainly expressed in the central nervous system and, to a lower extent, in several peripheral tissues such as adrenal gland, heart, lung, prostate, uterus, ovary, testis, bone marrow, thymus and tonsils.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb1]
<Options>: A: cannabinoid receptor 1 (homo sapiens) (aka cannabinoid receptor 1)
B: cb1a (mus musculus) (aka cannabinoid receptor 1)
C: cb1 (rattus norvegicus) (aka cannabinoid receptor 1)
D: None of the above. | [A] |
<Instruct>: Given the context 'In contrast, the CB2 gene, which is not expressed in the brain, was particularly abundant in immune tissues, with an expression level 10-100-fold higher than that of CB1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2; cb1]
<Options>: A: cannabinoid receptor 1 (rattus norvegicus) (aka cannabinoid receptor 1)
B: cb1a (mus musculus) (aka cannabinoid receptor 1)
C: cb1 (homo sapiens) (aka cannabinoid receptor 1)
D: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
E: cb2 (homo sapiens) (aka cannabinoid receptor 2)
F: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
G: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
H: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
I: None of the above. | [E; C] |
<Instruct>: Given the context 'In contrast, the CB2 gene, which is not expressed in the brain, was particularly abundant in immune tissues, with an expression level 10-100-fold higher than that of CB1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2; cb1]
<Options>: A: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
B: cb1a (homo sapiens) (aka cannabinoid receptor 1)
C: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
D: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2)
E: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
F: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
G: cannabinoid receptor 1 (rattus norvegicus) (aka cannabinoid receptor 1)
H: cb1a (mus musculus) (aka cannabinoid receptor 1)
I: None of the above. | [D; B] |
<Instruct>: Given the context 'Although CB2 mRNA was also detected in some other peripheral tissues, its level remained very low.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2]
<Options>: A: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
B: cb2 (homo sapiens) (aka cannabinoid receptor 2)
C: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
D: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
E: cmkbr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
F: None of the above. | [B] |
<Instruct>: Given the context 'In spleen and tonsils, the CB2 mRNA content was equivalent to that of CB1 mRNA in the central nervous system.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2; cb1]
<Options>: A: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2)
B: cb1 (rattus norvegicus) (aka cannabinoid receptor 1)
C: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
D: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
E: cb1a (homo sapiens) (aka cannabinoid receptor 1)
F: cb1a (mus musculus) (aka cannabinoid receptor 1)
G: ckr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
H: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
I: None of the above. | [A; E] |
<Instruct>: Given the context 'In spleen and tonsils, the CB2 mRNA content was equivalent to that of CB1 mRNA in the central nervous system.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2; cb1]
<Options>: A: cannabinoid receptor 1 (rattus norvegicus) (aka cannabinoid receptor 1)
B: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
C: cb1 (mus musculus) (aka cannabinoid receptor 1)
D: cannabinoid receptor 1 (homo sapiens) (aka cannabinoid receptor 1)
E: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
F: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
G: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
H: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2)
I: None of the above. | [H; D] |
<Instruct>: Given the context 'Among the main human blood cell subpopulations, the distribution pattern of the CB2 mRNA displayed important variations.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2]
<Options>: A: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
B: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2)
C: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
D: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
E: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
F: None of the above. | [B] |
<Instruct>: Given the context 'The rank order of CB2 mRNA levels in these cells was B-cells > natural killer cells >> monocytes > polymorphonuclear neutrophil cells > T8 cells > T4 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2]
<Options>: A: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
B: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2)
C: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
D: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
E: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
F: None of the above. | [B] |
<Instruct>: Given the context 'The prevailing expression of the CB2 gene in immune tissues was confirmed by Northern-blot analysis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2]
<Options>: A: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
B: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
C: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
D: cb2 (homo sapiens) (aka cannabinoid receptor 2)
E: cmkbr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
F: None of the above. | [D] |
<Instruct>: Given the context 'In addition, the expression of the CB2 protein was demonstrated by an immunohistological analysis performed on tonsil sections using specific anti-(human CB2) IgG; this experiment showed that CB2 expression was restricted to B-lymphocyte-enriched areas of the mantle of secondary lymphoid follicles.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2]
<Options>: A: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
B: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
C: cb2 (homo sapiens) (aka cannabinoid receptor 2)
D: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
E: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
F: None of the above. | [C] |
<Instruct>: Given the context 'These results suggest that (a) CB1 and CB2 can be considered as tissue-selective antigens of the central nervous system and immune system, respectively, and (b) cannabinoids may exert specific receptor-mediated actions on the immune system through the CB2 receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb1; cb2]
<Options>: A: cb1r (rattus norvegicus) (aka cannabinoid receptor 1)
B: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
C: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
D: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
E: cb1 (homo sapiens) (aka cannabinoid receptor 1)
F: cb1a (mus musculus) (aka cannabinoid receptor 1)
G: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
H: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2)
I: None of the above. | [E; H] |
<Instruct>: Given the context 'These results suggest that (a) CB1 and CB2 can be considered as tissue-selective antigens of the central nervous system and immune system, respectively, and (b) cannabinoids may exert specific receptor-mediated actions on the immune system through the CB2 receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb1; cb2]
<Options>: A: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
B: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2)
C: cb1r (rattus norvegicus) (aka cannabinoid receptor 1)
D: cb1a (mus musculus) (aka cannabinoid receptor 1)
E: ckr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
F: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
G: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
H: cannabinoid receptor 1 (homo sapiens) (aka cannabinoid receptor 1)
I: None of the above. | [H; B] |
<Instruct>: Given the context 'Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [proteinase-activated receptor 2]
<Options>: A: prokr2 (homo sapiens) (aka prokineticin receptor 2)
B: par-1b (homo sapiens) (aka microtubule affinity regulating kinase 2)
C: par2 (homo sapiens) (f2r like trypsin receptor 1 (homo sapiens)) (aka f2r like trypsin receptor 1)
D: f2r (homo sapiens) (aka coagulation factor ii thrombin receptor)
E: f2r like thrombin or trypsin receptor 3 (homo sapiens) (aka f2r like thrombin or trypsin receptor 3)
F: None of the above. | [C] |
<Instruct>: Given the context 'Since the physiological agonist was unknown, the receptor was named proteinase-activated receptor 2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [proteinase-activated receptor 2]
<Options>: A: par-1b (homo sapiens) (aka microtubule affinity regulating kinase 2)
B: par2 (homo sapiens) (f2r like trypsin receptor 1 (homo sapiens)) (aka f2r like trypsin receptor 1)
C: par3 (homo sapiens) (coagulation factor ii thrombin receptor like 2 (homo sapiens)) (aka coagulation factor ii thrombin receptor like 2)
D: prokr2 (homo sapiens) (aka prokineticin receptor 2)
E: f2r (homo sapiens) (aka coagulation factor ii thrombin receptor)
F: None of the above. | [B] |
<Instruct>: Given the context 'By fluorescence in situ hybridization, the human proteinase-activated receptor 2 gene was mapped to chromosomal region 5q13, where, previously, the related thrombin receptor gene has been located.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [proteinase-activated receptor 2]
<Options>: A: f2r like thrombin or trypsin receptor 3 (homo sapiens) (aka f2r like thrombin or trypsin receptor 3)
B: f2r (homo sapiens) (aka coagulation factor ii thrombin receptor)
C: f2rl2 (homo sapiens) (aka coagulation factor ii thrombin receptor like 2)
D: par2 (homo sapiens) (f2r like trypsin receptor 1 (homo sapiens)) (aka f2r like trypsin receptor 1)
E: prokr2 (homo sapiens) (aka prokineticin receptor 2)
F: None of the above. | [D] |
<Instruct>: Given the context 'We have described a protein (Hep27)', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hep27]
<Options>: A: hsf-27 (homo sapiens) (aka cdk5 regulatory subunit associated protein 3)
B: hep27 (homo sapiens) (aka dehydrogenase/reductase 2)
C: hcp27 (homo sapiens) (aka cycs pseudogene 27)
D: hh27 (homo sapiens) (aka nescient helix-loop-helix 2)
E: es27 (homo sapiens) (aka ribosomal protein s27)
F: None of the above. | [B] |
<Instruct>: Given the context 'The synthesis of Hep27 is inhibited in cells that, released from the butyrate block, have resumed DNA synthesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hep27]
<Options>: A: hel-s-27 (homo sapiens) (aka serpin family b member 1)
B: lc27 (homo sapiens) (aka lysosomal protein transmembrane 4 beta)
C: hep27 (mus musculus) (aka dehydrogenase/reductase member 2)
D: hep27 (homo sapiens) (aka dehydrogenase/reductase 2)
E: gp27 (homo sapiens) (aka cd151 molecule (raph blood group))
F: None of the above. | [D] |
<Instruct>: Given the context 'This report describes the cloning and the characterization of the cDNA coding for the Hep27 protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hep27]
<Options>: A: hsf-27 (homo sapiens) (aka cdk5 regulatory subunit associated protein 3)
B: hcp27 (homo sapiens) (aka cycs pseudogene 27)
C: hh27 (homo sapiens) (aka nescient helix-loop-helix 2)
D: lc27 (homo sapiens) (aka lysosomal protein transmembrane 4 beta)
E: hep27 (homo sapiens) (aka dehydrogenase/reductase 2)
F: None of the above. | [E] |
<Instruct>: Given the context 'The translation of the Hep27 cDNA predicts an amino acid sequence that can be aligned with those of the known short-chain alcohol dehydrogenase enzymes (SCAD) family.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hep27]
<Options>: A: hsf-27 (homo sapiens) (aka cdk5 regulatory subunit associated protein 3)
B: hep27 (homo sapiens) (aka dehydrogenase/reductase 2)
C: hh27 (homo sapiens) (aka nescient helix-loop-helix 2)
D: hep27 (mus musculus) (aka dehydrogenase/reductase member 2)
E: ncc27 (homo sapiens) (aka chloride intracellular channel 1)
F: None of the above. | [B] |
<Instruct>: Given the context 'In agreement with its nuclear localization Hep27 has a region similar to the bipartite nuclear-targeting sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hep27]
<Options>: A: gp27 (homo sapiens) (aka cd151 molecule (raph blood group))
B: hep27 (homo sapiens) (aka dehydrogenase/reductase 2)
C: es27 (homo sapiens) (aka ribosomal protein s27)
D: hep27 (mus musculus) (aka dehydrogenase/reductase member 2)
E: hsf-27 (homo sapiens) (aka cdk5 regulatory subunit associated protein 3)
F: None of the above. | [B] |
<Instruct>: Given the context 'The study of Hep27 mRNA expression and protein synthesis suggests the existence of a regulation at the post-transcriptional level.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hep27]
<Options>: A: hel-s-27 (homo sapiens) (aka serpin family b member 1)
B: hep27 (homo sapiens) (aka dehydrogenase/reductase 2)
C: hh27 (homo sapiens) (aka nescient helix-loop-helix 2)
D: gp27 (homo sapiens) (aka cd151 molecule (raph blood group))
E: ncc27 (homo sapiens) (aka chloride intracellular channel 1)
F: None of the above. | [B] |
<Instruct>: Given the context 'The study of Hep27 mRNA expression and protein synthesis suggests the existence of a regulation at the post-transcriptional level.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hep27]
<Options>: A: hh27 (homo sapiens) (aka nescient helix-loop-helix 2)
B: gp27 (homo sapiens) (aka cd151 molecule (raph blood group))
C: hel-s-27 (homo sapiens) (aka serpin family b member 1)
D: ncc27 (homo sapiens) (aka chloride intracellular channel 1)
E: None of the above. | [E] |
<Instruct>: Given the context 'The possible nuclear role of the Hep27 protein is discussed.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hep27]
<Options>: A: hep27 (homo sapiens) (aka dehydrogenase/reductase 2)
B: hh27 (homo sapiens) (aka nescient helix-loop-helix 2)
C: es27 (homo sapiens) (aka ribosomal protein s27)
D: lc27 (homo sapiens) (aka lysosomal protein transmembrane 4 beta)
E: ncc27 (homo sapiens) (aka chloride intracellular channel 1)
F: None of the above. | [A] |
<Instruct>: Given the context 'Human papillomaviruses (HPVs) are associated with the majority of cervical cancers and encode a transforming protein, E6, that interacts with the tumor suppressor protein p53.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p53]
<Options>: A: ct53 (homo sapiens) (aka zinc finger protein 165)
B: p53cp (homo sapiens) (aka tumor protein p63)
C: trp53 (homo sapiens) (aka tumor protein p53)
D: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
E: tp73 (homo sapiens) (aka tumor protein p73)
F: None of the above. | [C] |
<Instruct>: Given the context 'Because E6 has p53-independent transforming activity, the yeast two-hybrid system was used to search for other E6-binding proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p53]
<Options>: A: tumor protein p73 (homo sapiens) (aka tumor protein p73)
B: ct53 (homo sapiens) (aka zinc finger protein 165)
C: tp53 (homo sapiens) (aka tumor protein p53)
D: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
E: rad53 (homo sapiens) (aka checkpoint kinase 2)
F: None of the above. | [C] |
<Instruct>: Given the context 'One such protein, E6BP, interacted with cancer-associated HPV E6 and with bovine papillomavirus type 1 (BPV-1) E6.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e6bp]
<Options>: A: transforming protein e5 (human papillomavirus 16) (aka transforming protein e5)
B: e6bp (homo sapiens) (aka reticulocalbin 2)
C: e6 (human papillomavirus 16) (aka protein e6*;transforming protein e6)
D: ubc6p (homo sapiens) (aka ubiquitin conjugating enzyme e2 j1)
E: ebbp (homo sapiens) (aka tripartite motif containing 16)
F: None of the above. | [B] |
<Instruct>: Given the context 'The transforming activity of BPV-1 E6 mutants correlated with their E6BP-binding ability.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e6bp]
<Options>: A: e3bp (homo sapiens) (aka pyruvate dehydrogenase complex component x)
B: 16e1bp (homo sapiens) (aka thyroid hormone receptor interactor 13)
C: ebbp (homo sapiens) (aka tripartite motif containing 16)
D: e6bp (homo sapiens) (aka reticulocalbin 2)
E: transforming protein e5 (human papillomavirus 16) (aka transforming protein e5)
F: None of the above. | [D] |
<Instruct>: Given the context 'E6BP is identical to a putative calcium-binding protein, ERC-55, that appears to be localized in the endoplasmic reticulum.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e6bp; erc-55]
<Options>: A: testis expressed 55 (xenopus tropicalis) (aka testis expressed 55)
B: ebbp (homo sapiens) (aka tripartite motif containing 16)
C: e3bp (homo sapiens) (aka pyruvate dehydrogenase complex component x)
D: e6-ap (homo sapiens) (aka ubiquitin protein ligase e3a)
E: protein e6*;transforming protein e6 (human papillomavirus 16) (aka protein e6*;transforming protein e6)
F: ct55 (homo sapiens) (aka cancer/testis antigen 55)
G: ercc5 (homo sapiens) (aka ercc excision repair 5, endonuclease)
H: e6bp (homo sapiens) (aka reticulocalbin 2)
I: testis expressed 55 (homo sapiens) (aka testis expressed 55)
J: None of the above. | [H; H] |
<Instruct>: Given the context 'E6BP is identical to a putative calcium-binding protein, ERC-55, that appears to be localized in the endoplasmic reticulum.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e6bp; erc-55]
<Options>: A: e6bp (homo sapiens) (aka reticulocalbin 2)
B: ebbp (homo sapiens) (aka tripartite motif containing 16)
C: ubc6p (homo sapiens) (aka ubiquitin conjugating enzyme e2 j1)
D: e3bp (homo sapiens) (aka pyruvate dehydrogenase complex component x)
E: ct55 (homo sapiens) (aka cancer/testis antigen 55)
F: 16e1bp (homo sapiens) (aka thyroid hormone receptor interactor 13)
G: testis expressed 55 (xenopus tropicalis) (aka testis expressed 55)
H: rad55 (saccharomyces cerevisiae s288c) (aka putative dna-dependent atpase rad55)
I: testis expressed 55 (homo sapiens) (aka testis expressed 55)
J: None of the above. | [A; A] |
<Instruct>: Given the context 'A phosphoinositide-3 kinase isotype, p110 gamma, was cloned and characterized.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p110 gamma]
<Options>: A: p110-alpha (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)
B: pi3k-c2-gamma (homo sapiens) (aka phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma)
C: p110gamma (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)
D: pi3kgamma (mus musculus) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)
E: p110beta (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta)
F: None of the above. | [C] |
<Instruct>: Given the context 'A phosphoinositide-3 kinase isotype, p110 gamma, was cloned and characterized.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p110 gamma]
<Options>: A: p110beta (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta)
B: pi3k-c2-gamma (homo sapiens) (aka phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma)
C: pi3kgamma (mus musculus) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)
D: p110-alpha (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)
E: None of the above. | [E] |
<Instruct>: Given the context 'The p110 gamma enzyme was activated in vitro by both the alpha and beta gamma subunits of heterotrimeric guanosine triphosphate (GTP)-binding proteins (G proteins) and did not interact with p85.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p110 gamma]
<Options>: A: p110gamma (mus musculus) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)
B: p110-alpha (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)
C: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma (homo sapiens) (aka phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma)
D: p110beta (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta)
E: pi3kgamma (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)
F: None of the above. | [E] |
<Instruct>: Given the context 'The p110 gamma isotype may link signaling through G protein-coupled receptors to the generation of phosphoinositide second messengers phosphorylated in the D-3 position.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p110 gamma]
<Options>: A: p110beta (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta)
B: pi3k-c2-gamma (homo sapiens) (aka phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma)
C: pi3kgamma (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)
D: pi3kgamma (mus musculus) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)
E: p110-alpha (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)
F: None of the above. | [C] |
<Instruct>: Given the context 'ZNF133 and ZNF140 have both the KRAB A- and KRAB B-boxes present at their N-terminus, whereas ZNF136 contains only the KRAB A-box.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [znf133; znf140; znf136]
<Options>: A: cg13612 (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
B: znf404 (homo sapiens) (aka zinc finger protein 404)
C: zinc finger protein 133 (homo sapiens) (aka zinc finger protein 133)
D: znf400 (homo sapiens) (aka zdhhc palmitoyltransferase 12)
E: bzip133 (glycine max) (aka putative bzip domain class transcription factor)
F: znf136 (homo sapiens) (aka zinc finger protein 136)
G: znf141 (homo sapiens) (zinc finger protein 141 (homo sapiens)) (aka zinc finger protein 141)
H: zinc finger protein 236 (homo sapiens) (aka zinc finger protein 236)
I: chromosome 8 c6orf136 homolog (xenopus tropicalis) (aka chromosome 8 c6orf136 homolog)
J: znf135 (homo sapiens) (aka zinc finger protein 135)
K: fam161 homolog famh-136 (caenorhabditis elegans) (aka fam161 homolog famh-136)
L: znf139 (homo sapiens) (aka zinc finger with krab and scan domains 1)
M: zinc finger protein 136 (homo sapiens) (aka zinc finger protein 136)
N: zinc finger protein 140 (homo sapiens) (aka zinc finger protein 140)
O: zinc finger protein 132 (homo sapiens) (aka zinc finger protein 132)
P: None of the above. | [C; N; F] |
<Instruct>: Given the context 'ZNF133 and ZNF140 have both the KRAB A- and KRAB B-boxes present at their N-terminus, whereas ZNF136 contains only the KRAB A-box.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [znf133; znf140; znf136]
<Options>: A: zinc finger protein 133 (homo sapiens) (aka zinc finger protein 133)
B: zinc finger protein 195 (homo sapiens) (aka zinc finger protein 195)
C: zinc finger protein 136 (homo sapiens) (aka zinc finger protein 136)
D: znf140 (homo sapiens) (aka zinc finger protein 140)
E: bzip133 (glycine max) (aka putative bzip domain class transcription factor)
F: zinc finger protein 135 (homo sapiens) (aka zinc finger protein 135)
G: ct136 (homo sapiens) (aka outer dense fiber of sperm tails 4)
H: znf40 (homo sapiens) (aka hivep zinc finger 1)
I: znf132 (homo sapiens) (aka zinc finger protein 132)
J: fam161 homolog famh-136 (caenorhabditis elegans) (aka fam161 homolog famh-136)
K: znf136 (homo sapiens) (aka zinc finger protein 136)
L: znf400 (homo sapiens) (aka zdhhc palmitoyltransferase 12)
M: rnf136 (homo sapiens) (aka baculoviral iap repeat containing 8)
N: znf140l (homo sapiens) (aka zinc finger protein 302)
O: znf139 (homo sapiens) (aka zinc finger with krab and scan domains 1)
P: None of the above. | [A; D; K] |
<Instruct>: Given the context 'ZNF133 and ZNF140 have both the KRAB A- and KRAB B-boxes present at their N-terminus, whereas ZNF136 contains only the KRAB A-box.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [znf133; znf140; znf136]
<Options>: A: zinc finger protein 136 (homo sapiens) (aka zinc finger protein 136)
B: znf140l (homo sapiens) (aka zinc finger protein 302)
C: znf400 (homo sapiens) (aka zdhhc palmitoyltransferase 12)
D: znf132 (homo sapiens) (aka zinc finger protein 132)
E: zinc finger protein 135 (homo sapiens) (aka zinc finger protein 135)
F: znf139 (homo sapiens) (aka zinc finger with krab and scan domains 1)
G: rnf140 (homo sapiens) (aka deltex e3 ubiquitin ligase 1)
H: znf140 (homo sapiens) (aka zinc finger protein 140)
I: znf136 (homo sapiens) (aka zinc finger protein 136)
J: zinc finger protein 195 (homo sapiens) (aka zinc finger protein 195)
K: fam161 homolog famh-136 (caenorhabditis elegans) (aka fam161 homolog famh-136)
L: ct136 (homo sapiens) (aka outer dense fiber of sperm tails 4)
M: znf133 (homo sapiens) (aka zinc finger protein 133)
N: rnf133 (homo sapiens) (aka ring finger protein 133)
O: zinc finger protein 236 (homo sapiens) (aka zinc finger protein 236)
P: None of the above. | [M; H; I] |
<Instruct>: Given the context 'We have previously demonstrated that the KRAB domains derived from ZNF133 and ZNF140 are potent transcriptional repression domains', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [znf133; znf140]
<Options>: A: znf140l (homo sapiens) (aka zinc finger protein 302)
B: bzip133 (glycine max) (aka putative bzip domain class transcription factor)
C: zinc finger protein 195 (homo sapiens) (aka zinc finger protein 195)
D: znf133 (homo sapiens) (aka zinc finger protein 133)
E: zinc finger protein 136 (homo sapiens) (aka zinc finger protein 136)
F: zinc finger protein 140 (homo sapiens) (aka zinc finger protein 140)
G: znf400 (homo sapiens) (aka zdhhc palmitoyltransferase 12)
H: znf141 (homo sapiens) (zinc finger protein 141 (homo sapiens)) (aka zinc finger protein 141)
I: znf135 (homo sapiens) (aka zinc finger protein 135)
J: znf404 (homo sapiens) (aka zinc finger protein 404)
K: None of the above. | [D; F] |
<Instruct>: Given the context 'We have previously demonstrated that the KRAB domains derived from ZNF133 and ZNF140 are potent transcriptional repression domains', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [znf133; znf140]
<Options>: A: znf140l (homo sapiens) (aka zinc finger protein 302)
B: zinc finger protein 132 (homo sapiens) (aka zinc finger protein 132)
C: znf404 (homo sapiens) (aka zinc finger protein 404)
D: zinc finger protein 140 (homo sapiens) (aka zinc finger protein 140)
E: bzip133 (glycine max) (aka putative bzip domain class transcription factor)
F: znf133 (homo sapiens) (aka zinc finger protein 133)
G: znf135 (homo sapiens) (aka zinc finger protein 135)
H: znf141 (homo sapiens) (zinc finger protein 141 (homo sapiens)) (aka zinc finger protein 141)
I: rnf140 (homo sapiens) (aka deltex e3 ubiquitin ligase 1)
J: rnf133 (homo sapiens) (aka ring finger protein 133)
K: None of the above. | [F; D] |
<Instruct>: Given the context 'The KRAB domain from ZNF136, containing only subdomain A, is a considerable weaker suppression domain; however, when fused to the heterologous KRAB B subdomain of ZNF10 (KOX1) the two subdomains from a KRAB domain which induces repression as potently as previously reported KRAB domains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [znf136; znf10; kox1]
<Options>: A: zinc finger protein 136 (homo sapiens) (aka zinc finger protein 136)
B: chromosome 8 c6orf136 homolog (xenopus tropicalis) (aka chromosome 8 c6orf136 homolog)
C: cg13612 (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
D: kox10 (homo sapiens) (aka zinc finger protein 17)
E: kox3 (homo sapiens) (aka zinc finger protein 12)
F: kox7 (homo sapiens) (aka zinc finger protein 44)
G: fam161 homolog famh-136 (caenorhabditis elegans) (aka fam161 homolog famh-136)
H: lethal (1) ts136 (drosophila melanogaster) (aka lethal (1) ts136)
I: kox8 (homo sapiens) (aka zinc finger protein 708)
J: zinc finger cchc domain-containing protein 10 (glycine max) (aka zinc finger cchc domain-containing protein 10)
K: znf210 (homo sapiens) (aka zinc finger protein 205)
L: znf10 (homo sapiens) (aka zinc finger protein 10)
M: zinc finger protein 10-like (glycine max) (aka zinc finger protein 10-like)
N: None of the above. | [A; L; L] |
<Instruct>: Given the context 'The KRAB domain from ZNF136, containing only subdomain A, is a considerable weaker suppression domain; however, when fused to the heterologous KRAB B subdomain of ZNF10 (KOX1) the two subdomains from a KRAB domain which induces repression as potently as previously reported KRAB domains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [znf136; znf10; kox1]
<Options>: A: zscan10 (homo sapiens) (aka zinc finger and scan domain containing 10)
B: zinc finger protein 236 (homo sapiens) (aka zinc finger protein 236)
C: zinc finger protein 10-like (glycine max) (aka zinc finger protein 10-like)
D: rnf136 (homo sapiens) (aka baculoviral iap repeat containing 8)
E: cg13612 (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
F: kox6 (homo sapiens) (aka zinc finger protein 14)
G: kox8 (homo sapiens) (aka zinc finger protein 708)
H: znf210 (homo sapiens) (aka zinc finger protein 205)
I: zinc finger protein 10 (homo sapiens) (aka zinc finger protein 10)
J: kox4 (homo sapiens) (aka zinc finger protein 7)
K: kox7 (homo sapiens) (aka zinc finger protein 44)
L: kox10 (homo sapiens) (aka zinc finger protein 17)
M: zinc finger protein 136 (homo sapiens) (aka zinc finger protein 136)
N: fam161 homolog famh-136 (caenorhabditis elegans) (aka fam161 homolog famh-136)
O: None of the above. | [M; I; I] |
<Instruct>: Given the context 'The KRAB domain from ZNF136, containing only subdomain A, is a considerable weaker suppression domain; however, when fused to the heterologous KRAB B subdomain of ZNF10 (KOX1) the two subdomains from a KRAB domain which induces repression as potently as previously reported KRAB domains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [znf136; znf10; kox1]
<Options>: A: znf136 (homo sapiens) (aka zinc finger protein 136)
B: cg13612 (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
C: kox7 (homo sapiens) (aka zinc finger protein 44)
D: ct136 (homo sapiens) (aka outer dense fiber of sperm tails 4)
E: zinc finger protein 10-like (glycine max) (aka zinc finger protein 10-like)
F: kox10 (homo sapiens) (aka zinc finger protein 17)
G: zinc finger protein 236 (homo sapiens) (aka zinc finger protein 236)
H: znf10 (homo sapiens) (aka zinc finger protein 10)
I: kox8 (homo sapiens) (aka zinc finger protein 708)
J: chromosome 8 c6orf136 homolog (xenopus tropicalis) (aka chromosome 8 c6orf136 homolog)
K: zinc finger and btb domain containing 10 (homo sapiens) (aka zinc finger and btb domain containing 10)
L: kox-1 (homo sapiens) (aka nadph oxidase 4)
M: znf210 (homo sapiens) (aka zinc finger protein 205)
N: None of the above. | [A; H; H] |
<Instruct>: Given the context 'One form of hereditary long QT (LQT3) has been linked to a mutation in the gene encoding the human heart voltage-gated sodium-channel alpha-subunit (SCN5A on chromosome 3p21).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [heart voltage-gated sodium-channel alpha-subunit; scn5a]
<Options>: A: scn5a (sus scrofa) (aka sodium voltage-gated channel alpha subunit 5)
B: scnn1a (homo sapiens) (aka sodium channel epithelial 1 subunit alpha)
C: scnn1 (homo sapiens) (aka sodium channel epithelial 1 subunit alpha)
D: scn1a (homo sapiens) (aka sodium voltage-gated channel alpha subunit 1)
E: scn5a (rattus norvegicus) (aka sodium voltage-gated channel alpha subunit 5)
F: sodium voltage-gated channel alpha subunit 5 (homo sapiens) (aka sodium voltage-gated channel alpha subunit 5)
G: None of the above. | [F; F] |
<Instruct>: Given the context 'One form of hereditary long QT (LQT3) has been linked to a mutation in the gene encoding the human heart voltage-gated sodium-channel alpha-subunit (SCN5A on chromosome 3p21).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [heart voltage-gated sodium-channel alpha-subunit; scn5a]
<Options>: A: scn1a (homo sapiens) (aka sodium voltage-gated channel alpha subunit 1)
B: scn5a (homo sapiens) (sodium voltage-gated channel alpha subunit 5 (homo sapiens)) (aka sodium voltage-gated channel alpha subunit 5)
C: scn5a (mus musculus) (aka sodium channel, voltage-gated, type v, alpha)
D: enacalpha (homo sapiens) (aka sodium channel epithelial 1 subunit alpha)
E: scn5a (rattus norvegicus) (aka sodium voltage-gated channel alpha subunit 5)
F: scn6a (homo sapiens) (aka sodium voltage-gated channel alpha subunit 7)
G: None of the above. | [B; B] |
<Instruct>: Given the context 'The effect of the cap on translation is mediated by the initiation factor eIF-4F, whereas the effect on pre-mRNA splicing involves a nuclear complex (CBC) composed of two cap binding proteins, CBP80 and CBP20.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eif-4f; cbp80; cbp20]
<Options>: A: cbp80 (arabidopsis thaliana) (aka arm repeat superfamily protein)
B: eif4f (homo sapiens) (eukaryotic translation initiation factor 4e (homo sapiens)) (aka eukaryotic translation initiation factor 4e)
C: cbp80 (homo sapiens) (aka nuclear cap binding protein subunit 1)
D: cbp80 (drosophila melanogaster) (aka cap binding protein 80)
E: cbp68 (homo sapiens) (aka annexin a6)
F: eukaryotic translation initiation factor 4h (homo sapiens) (aka eukaryotic translation initiation factor 4h)
G: cbp20 (drosophila melanogaster) (aka cap binding protein 20)
H: small subunit processome component 20 homolog (xenopus laevis) (aka small subunit processome component 20 homolog)
I: cbp80 (saccharomyces cerevisiae s288c) (aka sto1p)
J: eukaryotic translation initiation factor 4e-4 (caenorhabditis elegans) (aka eukaryotic translation initiation factor 4e-4)
K: eif4f (drosophila melanogaster) (eukaryotic translation initiation factor 4e4 (drosophila melanogaster)) (aka eukaryotic translation initiation factor 4e4)
L: 4f (drosophila melanogaster) (ecdysone-induced gene 4f (drosophila melanogaster)) (aka ecdysone-induced gene 4f)
M: cbp20 (arabidopsis thaliana) (aka cap-binding protein 20)
N: cbp20 (xenopus laevis) (aka nuclear cap binding protein subunit 2 l homeolog)
O: cbp20 (homo sapiens) (aka nuclear cap binding protein subunit 2)
P: None of the above. | [B; C; O] |
<Instruct>: Given the context 'The effect of the cap on translation is mediated by the initiation factor eIF-4F, whereas the effect on pre-mRNA splicing involves a nuclear complex (CBC) composed of two cap binding proteins, CBP80 and CBP20.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eif-4f; cbp80; cbp20]
<Options>: A: atcbp80 (arabidopsis thaliana) (aka arm repeat superfamily protein)
B: eukaryotic translation initiation factor 4b (homo sapiens) (aka eukaryotic translation initiation factor 4b)
C: cbp20 (homo sapiens) (aka nuclear cap binding protein subunit 2)
D: cbp68 (homo sapiens) (aka annexin a6)
E: eif4f (drosophila melanogaster) (eukaryotic translation initiation factor 4e4 (drosophila melanogaster)) (aka eukaryotic translation initiation factor 4e4)
F: fact80 (homo sapiens) (aka structure specific recognition protein 1)
G: cbp80 (mus musculus) (aka nuclear cap binding protein subunit 1)
H: eukaryotic translation initiation factor 4e-4 (caenorhabditis elegans) (aka eukaryotic translation initiation factor 4e-4)
I: eukaryotic translation initiation factor 4h (homo sapiens) (aka eukaryotic translation initiation factor 4h)
J: cbp20 (saccharomyces cerevisiae s288c) (aka nuclear cap-binding protein subunit cbc2)
K: small subunit processome component 20 homolog (xenopus laevis) (aka small subunit processome component 20 homolog)
L: eukaryotic translation initiation factor 4e (homo sapiens) (aka eukaryotic translation initiation factor 4e)
M: cbp20 (xenopus laevis) (aka nuclear cap binding protein subunit 2 l homeolog)
N: cbp80 (homo sapiens) (aka nuclear cap binding protein subunit 1)
O: small subunit processome component 20 homolog (glycine max) (aka small subunit processome component 20 homolog)
P: None of the above. | [L; N; C] |
<Instruct>: Given the context 'The effect of the cap on translation is mediated by the initiation factor eIF-4F, whereas the effect on pre-mRNA splicing involves a nuclear complex (CBC) composed of two cap binding proteins, CBP80 and CBP20.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eif-4f; cbp80; cbp20]
<Options>: A: cbp86 (homo sapiens) (aka calcium binding tyrosine phosphorylation regulated)
B: cap binding protein 20 (drosophila melanogaster) (aka cap binding protein 20)
C: fact80 (homo sapiens) (aka structure specific recognition protein 1)
D: cbp20 (homo sapiens) (aka nuclear cap binding protein subunit 2)
E: small subunit processome component 20 homolog (xenopus laevis) (aka small subunit processome component 20 homolog)
F: cbp80 (homo sapiens) (aka nuclear cap binding protein subunit 1)
G: 4f (drosophila melanogaster) (eip4f (drosophila melanogaster)) (aka eip4f)
H: cbp20 (arabidopsis thaliana) (aka cap-binding protein 20)
I: eukaryotic translation initiation factor 4e-4 (caenorhabditis elegans) (aka eukaryotic translation initiation factor 4e-4)
J: cbp80 (mus musculus) (aka nuclear cap binding protein subunit 1)
K: cbp80 (drosophila melanogaster) (aka cap binding protein 80)
L: cbp20 (xenopus laevis) (aka nuclear cap binding protein subunit 2 l homeolog)
M: eukaryotic translation initiation factor 4h (homo sapiens) (aka eukaryotic translation initiation factor 4h)
N: eif-4e (homo sapiens) (aka eukaryotic translation initiation factor 4e)
O: eif4f (drosophila melanogaster) (eukaryotic translation initiation factor 4e1 (drosophila melanogaster)) (aka eukaryotic translation initiation factor 4e1)
P: None of the above. | [N; F; D] |
<Instruct>: Given the context 'Antibodies against recombinant CBP20 prevent interaction of CBC with capped RNAs in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cbp20]
<Options>: A: small subunit processome component 20 homolog (xenopus laevis) (aka small subunit processome component 20 homolog)
B: cbp20 (homo sapiens) (aka nuclear cap binding protein subunit 2)
C: cbp20 (arabidopsis thaliana) (aka cap-binding protein 20)
D: cbp20 (saccharomyces cerevisiae s288c) (aka nuclear cap-binding protein subunit cbc2)
E: cbp20 (xenopus laevis) (aka nuclear cap binding protein subunit 2 l homeolog)
F: None of the above. | [B] |
<Instruct>: Given the context 'Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [carboxypeptidase e]
<Options>: A: carboxypeptidase e (gallus gallus) (aka carboxypeptidase e)
B: carboxypeptidase e (xenopus tropicalis) (aka carboxypeptidase e)
C: peptidase e (homo sapiens) (aka peptidase e)
D: carboxypeptidase e (mus musculus) (aka carboxypeptidase e)
E: carboxypeptidase e (bos taurus) (aka carboxypeptidase e)
F: None of the above. | [D] |
<Instruct>: Given the context 'The fat mutation maps to mouse chromosome 8, very close to the gene for carboxypeptidase E (Cpe), which encodes an enzyme (CPE) that processes prohormone intermediates such as proinsulin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [carboxypeptidase e; cpe]
<Options>: A: carboxypeptidase e (rattus norvegicus) (aka carboxypeptidase e)
B: cpeb (homo sapiens) (aka cytoplasmic polyadenylation element binding protein 1)
C: peptidase e (homo sapiens) (aka peptidase e)
D: carboxypeptidase e (oryctolagus cuniculus) (cpe (oryctolagus cuniculus)) (aka carboxypeptidase e)
E: carboxypeptidase e (homo sapiens) (aka carboxypeptidase e)
F: cpe (gallus gallus) (aka carboxypeptidase e)
G: carboxypeptidase e (gallus gallus) (aka carboxypeptidase e)
H: cpe (homo sapiens) (aka carboxypeptidase e)
I: cpe1 (homo sapiens) (aka cytochrome p450 family 2 subfamily e member 1)
J: carboxypeptidase e (mus musculus) (aka carboxypeptidase e)
K: None of the above. | [J; J] |
<Instruct>: Given the context 'The fat mutation maps to mouse chromosome 8, very close to the gene for carboxypeptidase E (Cpe), which encodes an enzyme (CPE) that processes prohormone intermediates such as proinsulin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [carboxypeptidase e; cpe]
<Options>: A: carboxypeptidase e (bos taurus) (aka carboxypeptidase e)
B: carboxypeptidase e (homo sapiens) (aka carboxypeptidase e)
C: cpepe (drosophila melanogaster) (aka silver)
D: carboxypeptidase e (mus musculus) (aka carboxypeptidase e)
E: cpe1 (homo sapiens) (aka cytochrome p450 family 2 subfamily e member 1)
F: carboxypeptidase e (sus scrofa) (aka carboxypeptidase e)
G: carboxypeptidase e (oryctolagus cuniculus) (cpe (oryctolagus cuniculus)) (aka carboxypeptidase e)
H: cpea (escherichia coli str. k-12 substr. mg1655) (aka exodeoxyribonuclease i)
I: carboxypeptidase o (homo sapiens) (aka carboxypeptidase o)
J: cpe (homo sapiens) (aka carboxypeptidase e)
K: None of the above. | [D; D] |
<Instruct>: Given the context 'We now demonstrate a defect in proinsulin processing associated with the virtual absence of CPE activity in extracts of fat/fat pancreatic islets and pituitaries.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cpe]
<Options>: A: cpepe (drosophila melanogaster) (aka silver)
B: cpe (homo sapiens) (aka carboxypeptidase e)
C: cpe (gallus gallus) (aka carboxypeptidase e)
D: cpea (escherichia coli str. k-12 substr. mg1655) (aka exodeoxyribonuclease i)
E: carboxypeptidase e (oryctolagus cuniculus) (cpe (oryctolagus cuniculus)) (aka carboxypeptidase e)
F: None of the above. | [F] |
<Instruct>: Given the context 'A single Ser202Pro mutation distinguishes the mutant Cpe allele, and abolishes enzymatic activity in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cpe]
<Options>: A: cpepe (drosophila melanogaster) (aka silver)
B: carboxypeptidase e (oryctolagus cuniculus) (cpe (oryctolagus cuniculus)) (aka carboxypeptidase e)
C: cpe1 (homo sapiens) (aka cytochrome p450 family 2 subfamily e member 1)
D: cpeb (homo sapiens) (aka cytoplasmic polyadenylation element binding protein 1)
E: cpea (escherichia coli str. k-12 substr. mg1655) (aka exodeoxyribonuclease i)
F: None of the above. | [F] |
<Instruct>: Given the context 'A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [translin]
<Options>: A: translin (xenopus tropicalis) (aka translin)
B: translin-like (bos taurus) (aka translin-like)
C: translin (mus musculus) (aka translin)
D: translin-like (xenopus tropicalis) (aka translin-like)
E: translin (homo sapiens) (aka translin)
F: None of the above. | [E] |
<Instruct>: Given the context 'We have identified a novel gene, Translin, encoding a protein which specifically binds to consensus sequences at breakpoint junctions of chromosomal translocations in many cases of lymphoid malignancies.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [translin]
<Options>: A: translin (drosophila melanogaster) (aka translin)
B: translin (homo sapiens) (aka translin)
C: translin (bos taurus) (aka translin)
D: translin-like (xenopus tropicalis) (aka translin-like)
E: translin-like (bos taurus) (aka translin-like)
F: None of the above. | [B] |
<Instruct>: Given the context 'The encoded protein, Translin, is a previously undescribed type with no significant similarity to known proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [translin]
<Options>: A: translin (homo sapiens) (aka translin)
B: translin (mus musculus) (aka translin)
C: translin (sus scrofa) (aka translin)
D: translin-like (bos taurus) (aka translin-like)
E: translin-like (xenopus tropicalis) (aka translin-like)
F: None of the above. | [A] |
<Instruct>: Given the context 'In the native form, Translin polypeptides form a multimeric structure which is responsible for its DNA binding activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [translin]
<Options>: A: translin (drosophila melanogaster) (aka translin)
B: translin (xenopus tropicalis) (aka translin)
C: translin (danio rerio) (aka translin)
D: translin (bos taurus) (aka translin)
E: translin (homo sapiens) (aka translin)
F: None of the above. | [E] |
<Instruct>: Given the context 'Nuclear localization of Translin is limited to lymphoid cell lines, raising the intriguing possibility that nuclear transport of Translin is regulated in a physiologically significant way such that active nuclear transport is associated with the lymphoid specific process known as Ig/TCR gene rearrangement.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [translin]
<Options>: A: translin (sus scrofa) (aka translin)
B: translin (homo sapiens) (aka translin)
C: translin (drosophila melanogaster) (aka translin)
D: translin-like (bos taurus) (aka translin-like)
E: translin (xenopus tropicalis) (aka translin)
F: None of the above. | [B] |
<Instruct>: Given the context 'Nuclear localization of Translin is limited to lymphoid cell lines, raising the intriguing possibility that nuclear transport of Translin is regulated in a physiologically significant way such that active nuclear transport is associated with the lymphoid specific process known as Ig/TCR gene rearrangement.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [translin]
<Options>: A: translin (xenopus tropicalis) (aka translin)
B: translin-like (bos taurus) (aka translin-like)
C: translin (drosophila melanogaster) (aka translin)
D: translin (sus scrofa) (aka translin)
E: None of the above. | [E] |
<Instruct>: Given the context 'Marked deficiency of muscle adhalin, a 50 kDa sarcolemmal dystrophin-associated glycoprotein, has been reported in severe childhood autosomal recessive muscular dystrophy (SCARMD).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adhalin; 50 kda sarcolemmal dystrophin-associated glycoprotein]
<Options>: A: 50dag (mus musculus) (aka sarcoglycan, alpha (dystrophin-associated glycoprotein))
B: adhalin (xenopus tropicalis) (aka sarcoglycan alpha)
C: 35kda (mus musculus) (sarcoglycan, gamma (dystrophin-associated glycoprotein) (mus musculus)) (aka sarcoglycan, gamma (dystrophin-associated glycoprotein))
D: dctn-50 (mus musculus) (aka dynactin 2)
E: adn (homo sapiens) (aka complement factor d)
F: apln (homo sapiens) (aka apelin)
G: arcadlin (homo sapiens) (aka protocadherin 8)
H: adhalin (homo sapiens) (aka sarcoglycan alpha)
I: sarcoglycan, delta (dystrophin-associated glycoprotein) (mus musculus) (aka sarcoglycan, delta (dystrophin-associated glycoprotein))
J: None of the above. | [H; H] |
<Instruct>: Given the context 'Marked deficiency of muscle adhalin, a 50 kDa sarcolemmal dystrophin-associated glycoprotein, has been reported in severe childhood autosomal recessive muscular dystrophy (SCARMD).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adhalin; 50 kda sarcolemmal dystrophin-associated glycoprotein]
<Options>: A: adhalin (homo sapiens) (aka sarcoglycan alpha)
B: 50dag (mus musculus) (aka sarcoglycan, alpha (dystrophin-associated glycoprotein))
C: adhalin (xenopus laevis) (aka sarcoglycan alpha l homeolog)
D: sarcoglycan, delta (dystrophin-associated glycoprotein) (mus musculus) (aka sarcoglycan, delta (dystrophin-associated glycoprotein))
E: arcadlin (homo sapiens) (aka protocadherin 8)
F: 50kda (mus musculus) (aka polymerase (dna directed), delta 2, regulatory subunit)
G: ankyrin repeat domain 50 (mus musculus) (aka ankyrin repeat domain 50)
H: anln (homo sapiens) (aka anillin, actin binding protein)
I: adhalin (xenopus tropicalis) (aka sarcoglycan alpha)
J: None of the above. | [A; A] |
<Instruct>: Given the context 'Adhalin deficiency has been found in SCARMD patients from North Africa Europe, Brazil, Japan and North America (SLR & KPC, unpublished data).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adhalin]
<Options>: A: dystonin (homo sapiens) (aka dystonin)
B: arcadlin (homo sapiens) (aka protocadherin 8)
C: adhalin (xenopus tropicalis) (aka sarcoglycan alpha)
D: anillin, actin binding protein (homo sapiens) (aka anillin, actin binding protein)
E: adhalin (homo sapiens) (aka sarcoglycan alpha)
F: None of the above. | [E] |
<Instruct>: Given the context 'The disease was initially linked to an unidentified gene on chromosome 13 in families from North Africa, and to the adhalin gene itself on chromosome 17q in one French family in which missense mutations were identified.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adhalin]
<Options>: A: adhalin (homo sapiens) (aka sarcoglycan alpha)
B: anillin, actin binding protein (homo sapiens) (aka anillin, actin binding protein)
C: adhalin (xenopus laevis) (aka sarcoglycan alpha l homeolog)
D: adn (homo sapiens) (aka complement factor d)
E: arcadlin (homo sapiens) (aka protocadherin 8)
F: None of the above. | [A] |
<Instruct>: Given the context 'Thus there are two kinds of myopathies with adhalin deficiency: one with a primary defect of adhalin (primary adhalinopathies), and one in which absence of adhalin is secondary to a separate gene defect on chromosome 13.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adhalin]
<Options>: A: dystonin (homo sapiens) (aka dystonin)
B: adhalin (xenopus tropicalis) (aka sarcoglycan alpha)
C: adhalin (homo sapiens) (aka sarcoglycan alpha)
D: anillin, actin binding protein (homo sapiens) (aka anillin, actin binding protein)
E: arcadlin (homo sapiens) (aka protocadherin 8)
F: None of the above. | [C] |
<Instruct>: Given the context 'We have examined the importance of primary adhalinopathies among myopathies with adhalin deficiency, and describe several additional mutations (null and missense) in the adhalin gene in 10 new families from Europe and North Africa.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adhalin]
<Options>: A: apln (homo sapiens) (aka apelin)
B: adhalin (homo sapiens) (aka sarcoglycan alpha)
C: dystonin (homo sapiens) (aka dystonin)
D: ankyrin-1-like (danio rerio) (aka ankyrin-1-like)
E: arcadlin (homo sapiens) (aka protocadherin 8)
F: None of the above. | [B] |
<Instruct>: Given the context 'Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [macrophage inflammatory protein 1 alpha; rantes receptor]
<Options>: A: c-c motif chemokine receptor 6 (homo sapiens) (aka c-c motif chemokine receptor 6)
B: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
C: mip-1d (homo sapiens) (aka c-c motif chemokine ligand 15)
D: mcp-1 (homo sapiens) (aka c-c motif chemokine ligand 2)
E: c-c motif chemokine receptor 2 (homo sapiens) (aka c-c motif chemokine receptor 2)
F: mip-1-alpha (homo sapiens) (aka c-c motif chemokine ligand 3)
G: c-x-c motif chemokine ligand 1 (homo sapiens) (aka c-x-c motif chemokine ligand 1)
H: c-x3-c motif chemokine ligand 1 (homo sapiens) (aka c-x3-c motif chemokine ligand 1)
I: c-c motif chemokine receptor 1 (homo sapiens) (aka c-c motif chemokine receptor 1)
J: c-c motif chemokine receptor 5 (homo sapiens) (aka c-c motif chemokine receptor 5)
K: None of the above. | [I; I] |
<Instruct>: Given the context 'Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [macrophage inflammatory protein 1 alpha; rantes receptor]
<Options>: A: mip-1-alpha (homo sapiens) (aka c-c motif chemokine ligand 3)
B: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
C: c-c motif chemokine receptor 6 (homo sapiens) (aka c-c motif chemokine receptor 6)
D: mcp-1 (homo sapiens) (aka c-c motif chemokine ligand 2)
E: c-c motif chemokine receptor 2 (homo sapiens) (aka c-c motif chemokine receptor 2)
F: c-c motif chemokine receptor 5 (homo sapiens) (aka c-c motif chemokine receptor 5)
G: mip-1d (homo sapiens) (aka c-c motif chemokine ligand 15)
H: c-x-c motif chemokine ligand 1 (homo sapiens) (aka c-x-c motif chemokine ligand 1)
I: c-x3-c motif chemokine ligand 1 (homo sapiens) (aka c-x3-c motif chemokine ligand 1)
J: None of the above. | [J; J] |
<Instruct>: Given the context 'Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [macrophage inflammatory protein 1 alpha; rantes receptor]
<Options>: A: mcp-1 (homo sapiens) (aka c-c motif chemokine ligand 2)
B: c-x-c motif chemokine ligand 1 (homo sapiens) (aka c-x-c motif chemokine ligand 1)
C: c-c motif chemokine ligand 1 (homo sapiens) (aka c-c motif chemokine ligand 1)
D: c-c motif chemokine receptor 6 (homo sapiens) (aka c-c motif chemokine receptor 6)
E: c-c motif chemokine receptor 3 (homo sapiens) (aka c-c motif chemokine receptor 3)
F: mip1ap (homo sapiens) (aka c-c motif chemokine ligand 3 like 1)
G: mip-1d (homo sapiens) (aka c-c motif chemokine ligand 15)
H: ckr-1 (homo sapiens) (c-c motif chemokine receptor 1 (homo sapiens)) (aka c-c motif chemokine receptor 1)
I: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
J: c-c motif chemokine receptor 2 (homo sapiens) (aka c-c motif chemokine receptor 2)
K: None of the above. | [H; H] |
<Instruct>: Given the context 'The chemokine beta family is comprised of at least six distinct cytokines that regulate trafficking of phagocytes and lymphocytes in mammalian species; at least one of these, macrophage inflammatory protein 1 alpha (MIP-1 alpha), also regulates the growth of hematopoietic stem cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [macrophage inflammatory protein 1 alpha; mip-1 alpha]
<Options>: A: mip1ap (homo sapiens) (aka c-c motif chemokine ligand 3 like 1)
B: mcp-1 (homo sapiens) (aka c-c motif chemokine ligand 2)
C: mip-1d (homo sapiens) (aka c-c motif chemokine ligand 15)
D: c-x3-c motif chemokine ligand 1 (homo sapiens) (aka c-x3-c motif chemokine ligand 1)
E: c-c motif chemokine ligand 1 (homo sapiens) (aka c-c motif chemokine ligand 1)
F: mip1b (homo sapiens) (aka c-c motif chemokine ligand 4)
G: mip-3-alpha (homo sapiens) (aka c-c motif chemokine ligand 20)
H: None of the above. | [H; H] |
<Instruct>: Given the context 'The chemokine beta family is comprised of at least six distinct cytokines that regulate trafficking of phagocytes and lymphocytes in mammalian species; at least one of these, macrophage inflammatory protein 1 alpha (MIP-1 alpha), also regulates the growth of hematopoietic stem cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [macrophage inflammatory protein 1 alpha; mip-1 alpha]
<Options>: A: mip1a (homo sapiens) (aka c-c motif chemokine ligand 3)
B: mip1ap (homo sapiens) (aka c-c motif chemokine ligand 3 like 1)
C: mcp-1 (homo sapiens) (aka c-c motif chemokine ligand 2)
D: mip1b (homo sapiens) (aka c-c motif chemokine ligand 4)
E: c-c motif chemokine ligand 1 (homo sapiens) (aka c-c motif chemokine ligand 1)
F: c-x-c motif chemokine ligand 1 (homo sapiens) (aka c-x-c motif chemokine ligand 1)
G: c-x3-c motif chemokine ligand 1 (homo sapiens) (aka c-x3-c motif chemokine ligand 1)
H: mip-1d (homo sapiens) (aka c-c motif chemokine ligand 15)
I: None of the above. | [I; I] |
<Instruct>: Given the context 'We now show that MIP-1 alpha and the related beta chemokine, RANTES, induce transient alterations in intracellular Ca2+ concentration in polymorphonuclear leukocytes that can be reciprocally and specifically desensitized, suggesting a common receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mip-1 alpha; beta chemokine; rantes]
<Options>: A: mip3b (homo sapiens) (aka c-c motif chemokine ligand 19)
B: ccl25 (homo sapiens) (aka c-c motif chemokine ligand 25)
C: grob (homo sapiens) (aka c-x-c motif chemokine ligand 2)
D: rantes (sus scrofa) (aka c-c motif chemokine ligand 5)
E: mip-1d (homo sapiens) (aka c-c motif chemokine ligand 15)
F: mip-4a (homo sapiens) (aka c-c motif chemokine ligand 26)
G: c-x3-c motif chemokine ligand 1 (homo sapiens) (aka c-x3-c motif chemokine ligand 1)
H: scya7 (homo sapiens) (aka c-c motif chemokine ligand 7)
I: rantes (xenopus tropicalis) (aka chemokine (c-c motif) ligand 5)
J: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
K: mip1ap (homo sapiens) (aka c-c motif chemokine ligand 3 like 1)
L: mip-1-beta (xenopus tropicalis) (aka c-c motif chemokine ligand 4)
M: c-c motif chemokine ligand 1 (homo sapiens) (aka c-c motif chemokine ligand 1)
N: c-x-c motif chemokine ligand 3 (homo sapiens) (aka c-x-c motif chemokine ligand 3)
O: None of the above. | [O; J; J] |
<Instruct>: Given the context 'We now show that MIP-1 alpha and the related beta chemokine, RANTES, induce transient alterations in intracellular Ca2+ concentration in polymorphonuclear leukocytes that can be reciprocally and specifically desensitized, suggesting a common receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mip-1 alpha; beta chemokine; rantes]
<Options>: A: mip-4a (homo sapiens) (aka c-c motif chemokine ligand 26)
B: c-c motif chemokine ligand 3 (homo sapiens) (aka c-c motif chemokine ligand 3)
C: rantes (sus scrofa) (aka c-c motif chemokine ligand 5)
D: grob (homo sapiens) (aka c-x-c motif chemokine ligand 2)
E: c-c motif chemokine ligand 1 (homo sapiens) (aka c-c motif chemokine ligand 1)
F: mip-1d (homo sapiens) (aka c-c motif chemokine ligand 15)
G: rantes (xenopus tropicalis) (aka chemokine (c-c motif) ligand 5)
H: c-x3-c motif chemokine ligand 1 (homo sapiens) (aka c-x3-c motif chemokine ligand 1)
I: mip1b (homo sapiens) (aka c-c motif chemokine ligand 4)
J: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
K: mcp-3 (homo sapiens) (aka c-c motif chemokine ligand 7)
L: c-c motif chemokine ligand 2 (homo sapiens) (aka c-c motif chemokine ligand 2)
M: c-x-c motif chemokine ligand 3 (homo sapiens) (aka c-x-c motif chemokine ligand 3)
N: c-c motif chemokine 3 (sus scrofa) (aka c-c motif chemokine 3)
O: None of the above. | [O; J; J] |
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