instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
|---|---|---|
<Instruct>: Given the context 'We now show that MIP-1 alpha and the related beta chemokine, RANTES, induce transient alterations in intracellular Ca2+ concentration in polymorphonuclear leukocytes that can be reciprocally and specifically desensitized, suggesting a common receptor.', select the correct biomedical conce... | <Mentions>: [mip-1 alpha; beta chemokine; rantes]
<Options>: A: mip1b (homo sapiens) (aka c-c motif chemokine ligand 4)
B: c-c motif chemokine ligand 3 (homo sapiens) (aka c-c motif chemokine ligand 3)
C: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
D: mip-4a (homo sapiens) (aka c-c motif chemokine ligand 2... | [O; C; C] |
<Instruct>: Given the context 'It has approximately 33% amino acid identity with receptors for the alpha chemokine, interleukin 8, and may be the human homologue of the product of US28, an open reading frame of human cytomegalovirus.', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [alpha chemokine; interleukin 8]
<Options>: A: ccl8 (homo sapiens) (aka c-c motif chemokine ligand 8)
B: scya8 (homo sapiens) (aka c-c motif chemokine ligand 8)
C: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
D: il18 (homo sapiens) (aka interleukin 18)
E: fgf-8 (homo sapiens) (aka fibroblast gro... | [G; G] |
<Instruct>: Given the context 'It has approximately 33% amino acid identity with receptors for the alpha chemokine, interleukin 8, and may be the human homologue of the product of US28, an open reading frame of human cytomegalovirus.', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [alpha chemokine; interleukin 8]
<Options>: A: il-1f8 (homo sapiens) (aka interleukin 36 beta)
B: fgf-8 (homo sapiens) (aka fibroblast growth factor 8)
C: rantes (xenopus tropicalis) (aka chemokine (c-c motif) ligand 5)
D: c-x-c motif chemokine ligand 8 (homo sapiens) (aka c-x-c motif chemokine ligand 8)
E:... | [D; D] |
<Instruct>: Given the context 'p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2; p21cip1]
<Options>: A: cip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 3)
B: inhibitor of cdk, cyclin a1 interacting protein 1 (homo sapiens) (aka inhibitor of cdk, cyclin a1 interacting protein 1)
C: p21cip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1a)
D: p-cip1 (homo sapi... | [E; C] |
<Instruct>: Given the context 'p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2; p21cip1]
<Options>: A: inhibitor of cdk, cyclin a1 interacting protein 1 (homo sapiens) (aka inhibitor of cdk, cyclin a1 interacting protein 1)
B: p27kip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
C: p21 (homo sapiens) (cyclin dependent kinase inhibitor 1a (homo sapiens)) (aka cycl... | [E; C] |
<Instruct>: Given the context 'We describe a new CKI, p57KIP2, which is related to p21CIP1 and p27KIP1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2; p21cip1; p27kip1]
<Options>: A: p21cip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1a)
B: p-cip1 (homo sapiens) (aka ras association domain family member 9)
C: p21cip1 (xenopus tropicalis) (aka cyclin-dependent kinase inhibitor 1a)
D: p-cip2 (homo sapiens) (aka u2af homology motif kinas... | [J; A; M] |
<Instruct>: Given the context 'We describe a new CKI, p57KIP2, which is related to p21CIP1 and p27KIP1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2; p21cip1; p27kip1]
<Options>: A: p-cip2 (homo sapiens) (aka u2af homology motif kinase 1)
B: p-cip1 (homo sapiens) (aka ras association domain family member 9)
C: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
D: calcium/calmodulin dependent protein kinase ii inhibitor 2 (homo sa... | [G; K; J] |
<Instruct>: Given the context 'We describe a new CKI, p57KIP2, which is related to p21CIP1 and p27KIP1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2; p21cip1; p27kip1]
<Options>: A: kish2 (homo sapiens) (aka chromodomain helicase dna binding protein 9)
B: cyclin-dependent kinase inhibitor 1b (p27, kip1) (xenopus tropicalis) (aka cyclin-dependent kinase inhibitor 1b (p27, kip1))
C: kip2 (homo sapiens) (cyclin dependent kinase inhibitor 1c (homo ... | [C; H; K] |
<Instruct>: Given the context 'p57KIP2 is a potent, tight-binding inhibitor of several G1 cyclin/Cdk complexes, and its binding is cyclin dependent.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2]
<Options>: A: cdkn2c (homo sapiens) (aka cyclin dependent kinase inhibitor 2c)
B: kip2 (homo sapiens) (calcium and integrin binding family member 2 (homo sapiens)) (aka calcium and integrin binding family member 2)
C: p27kip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
D: p-cip2 (hom... | [E] |
<Instruct>: Given the context 'Unlike CIP1, KIP2 is not regulated by p53.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cip1; kip2; p53]
<Options>: A: cdkn1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1a)
B: p53cp (homo sapiens) (aka tumor protein p63)
C: ing2 (homo sapiens) (inhibitor of growth family member 2 (homo sapiens)) (aka inhibitor of growth family member 2)
D: tp53 (homo sapiens) (aka tumor protein p53)... | [A; E; D] |
<Instruct>: Given the context 'Unlike CIP1, KIP2 is not regulated by p53.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cip1; kip2; p53]
<Options>: A: cip2a (homo sapiens) (aka cellular inhibitor of pp2a)
B: kip2 (homo sapiens) (calcium and integrin binding family member 2 (homo sapiens)) (aka calcium and integrin binding family member 2)
C: cip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 3)
D: cdkn1 (homo sapien... | [D; M; K] |
<Instruct>: Given the context 'Unlike CIP1, KIP2 is not regulated by p53.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cip1; kip2; p53]
<Options>: A: cip1 (homo sapiens) (cyclin dependent kinase inhibitor 1a (homo sapiens)) (aka cyclin dependent kinase inhibitor 1a)
B: ckip-1 (homo sapiens) (aka pleckstrin homology domain containing o1)
C: cdkn2b (homo sapiens) (aka cyclin dependent kinase inhibitor 2b)
D: p532 (homo sapie... | [A; N; M] |
<Instruct>: Given the context 'Overexpression of p57KIP2 arrests cells in G1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2]
<Options>: A: cip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 3)
B: kip2 (homo sapiens) (cyclin dependent kinase inhibitor 1c (homo sapiens)) (aka cyclin dependent kinase inhibitor 1c)
C: p-cip2 (homo sapiens) (aka u2af homology motif kinase 1)
D: cdkn2 (homo sapiens) (cyclin dependent ... | [B] |
<Instruct>: Given the context 'p57KIP2 proteins have a complex structure.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2]
<Options>: A: p27kip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
B: p-cip2 (homo sapiens) (aka u2af homology motif kinase 1)
C: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
D: calcium/calmodulin dependent protein kinase ii inhibitor 2 (homo sapiens) (aka calcium... | [C] |
<Instruct>: Given the context 'Mouse p57KIP2 consists of four structurally distinct domains: an amino-terminal Cdk inhibitory domain, a proline-rich domain, an acidic-repeat region, and a carboxy-terminal domain conserved with p27KIP1.', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [p57kip2; p27kip1]
<Options>: A: cdkn1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1a)
B: p27k (homo sapiens) (aka proteasome 20s subunit alpha 6)
C: calcium/calmodulin dependent protein kinase ii inhibitor 2 (homo sapiens) (aka calcium/calmodulin dependent protein kinase ii inhibitor 2)
D: cyclin... | [H; I] |
<Instruct>: Given the context 'Mouse p57KIP2 consists of four structurally distinct domains: an amino-terminal Cdk inhibitory domain, a proline-rich domain, an acidic-repeat region, and a carboxy-terminal domain conserved with p27KIP1.', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [p57kip2; p27kip1]
<Options>: A: p27kip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
B: p27k (homo sapiens) (aka proteasome 20s subunit alpha 6)
C: cdkn2 (homo sapiens) (cyclin dependent kinase 2 (homo sapiens)) (aka cyclin dependent kinase 2)
D: kip1 (homo sapiens) (cyclin dependent kinase in... | [H; D] |
<Instruct>: Given the context 'Human p57KIP2 appears to have conserved the amino- and carboxy-terminal domains but has replaced the internal regions with sequences containing proline-alanine repeats.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opti... | <Mentions>: [p57kip2]
<Options>: A: cdkn2c (homo sapiens) (aka cyclin dependent kinase inhibitor 2c)
B: kip2 (homo sapiens) (cyclin dependent kinase inhibitor 1c (homo sapiens)) (aka cyclin dependent kinase inhibitor 1c)
C: p-cip2 (homo sapiens) (aka u2af homology motif kinase 1)
D: kip2 (homo sapiens) (calcium and int... | [B] |
<Instruct>: Given the context 'In situ hybridization during mouse embryogenesis revealed that KIP2 mRNA displays a striking pattern of expression during development, showing high level expression in skeletal muscle, brain, heart, lungs, and eye.', select the correct biomedical concept for each mention using the provide... | <Mentions>: [kip2]
<Options>: A: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
B: ing2 (homo sapiens) (inhibitor of growth family member 2 (homo sapiens)) (aka inhibitor of growth family member 2)
C: kip2 (homo sapiens) (calcium and integrin binding family member 2 (homo sapiens)) (aka calcium and i... | [A] |
<Instruct>: Given the context 'In situ hybridization during mouse embryogenesis revealed that KIP2 mRNA displays a striking pattern of expression during development, showing high level expression in skeletal muscle, brain, heart, lungs, and eye.', select the correct biomedical concept for each mention using the provide... | <Mentions>: [kip2]
<Options>: A: kip2 (homo sapiens) (calcium and integrin binding family member 2 (homo sapiens)) (aka calcium and integrin binding family member 2)
B: ing2 (homo sapiens) (inhibitor of growth family member 2 (homo sapiens)) (aka inhibitor of growth family member 2)
C: cdkn2b (homo sapiens) (aka cyclin... | [E] |
<Instruct>: Given the context 'Most of the KIP2-expressing cells are terminally differentiated, suggesting that p57KIP2 is involved in decisions to exit the cell cycle during development and differentiation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [kip2; p57kip2]
<Options>: A: kip2 (homo sapiens) (cyclin dependent kinase inhibitor 1c (homo sapiens)) (aka cyclin dependent kinase inhibitor 1c)
B: kip2 (homo sapiens) (calcium and integrin binding family member 2 (homo sapiens)) (aka calcium and integrin binding family member 2)
C: kish2 (homo sapiens) (... | [A; A] |
<Instruct>: Given the context 'Most of the KIP2-expressing cells are terminally differentiated, suggesting that p57KIP2 is involved in decisions to exit the cell cycle during development and differentiation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [kip2; p57kip2]
<Options>: A: calcium/calmodulin dependent protein kinase ii inhibitor 2 (homo sapiens) (aka calcium/calmodulin dependent protein kinase ii inhibitor 2)
B: cdkn2b (homo sapiens) (aka cyclin dependent kinase inhibitor 2b)
C: kip2 (homo sapiens) (cyclin dependent kinase inhibitor 1c (homo sapi... | [C; C] |
<Instruct>: Given the context 'Human KIP2 is located at 11p15.5, a region implicated in both sporadic cancers and Beckwith-Wiedemann syndrome, a familial cancer syndrome, marking it as a candidate tumor suppressor.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [kip2]
<Options>: A: cip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 3)
B: kip2 (homo sapiens) (calcium and integrin binding family member 2 (homo sapiens)) (aka calcium and integrin binding family member 2)
C: kip2 (homo sapiens) (cyclin dependent kinase inhibitor 1c (homo sapiens)) (aka cyclin ... | [C] |
<Instruct>: Given the context 'The discovery of a new member of the p21CIP1 inhibitor family with novel structural features and expression patterns suggests a complex role for these proteins in cell cycle control and development.', select the correct biomedical concept for each mention using the provided options. Answe... | <Mentions>: [p21cip1]
<Options>: A: p21cip1 (xenopus tropicalis) (aka cyclin-dependent kinase inhibitor 1a)
B: inhibitor of cdk, cyclin a1 interacting protein 1 (homo sapiens) (aka inhibitor of cdk, cyclin a1 interacting protein 1)
C: cyclin dependent kinase inhibitor 1a (homo sapiens) (aka cyclin dependent kinase inhi... | [C] |
<Instruct>: Given the context 'A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [interleukin-1 beta converting enzyme]
<Options>: A: caspase 1 (homo sapiens) (aka caspase 1)
B: casp2 (homo sapiens) (aka caspase 2)
C: casp7 (homo sapiens) (aka caspase 7)
D: casp16 (homo sapiens) (aka caspase 16, pseudogene)
E: ice1 (homo sapiens) (aka interactor of little elongation complex ell subunit ... | [A] |
<Instruct>: Given the context 'We have identified a novel cDNA encoding a protein (named TX) with > 50% overall sequence identity with the interleukin-1 beta converting enzyme (ICE) and approximately 30% sequence identity with the ICE homologs NEDD-2/ICH-1L and CED-3.', select the correct biomedical concept for each me... | <Mentions>: [tx; interleukin-1 beta converting enzyme; ice]
<Options>: A: ice1 (homo sapiens) (aka interactor of little elongation complex ell subunit 1)
B: ich-2 (homo sapiens) (aka caspase 4)
C: ice (xenopus laevis) (caspase 1 s homeolog (xenopus laevis)) (aka caspase 1 s homeolog)
D: tx1 (arabidopsis thaliana) (aka ... | [L; N; N] |
<Instruct>: Given the context 'We have identified a novel cDNA encoding a protein (named TX) with > 50% overall sequence identity with the interleukin-1 beta converting enzyme (ICE) and approximately 30% sequence identity with the ICE homologs NEDD-2/ICH-1L and CED-3.', select the correct biomedical concept for each me... | <Mentions>: [tx; interleukin-1 beta converting enzyme; ice]
<Options>: A: casp3 (homo sapiens) (aka caspase 3)
B: tx1 (arabidopsis thaliana) (aka mate efflux family protein)
C: ice (xenopus laevis) (caspase 1 s homeolog (xenopus laevis)) (aka caspase 1 s homeolog)
D: ich-2 (homo sapiens) (aka caspase 4)
E: txn (xenopus... | [N; G; G] |
<Instruct>: Given the context 'We have identified a novel cDNA encoding a protein (named TX) with > 50% overall sequence identity with the interleukin-1 beta converting enzyme (ICE) and approximately 30% sequence identity with the ICE homologs NEDD-2/ICH-1L and CED-3.', select the correct biomedical concept for each me... | <Mentions>: [tx; interleukin-1 beta converting enzyme; ice]
<Options>: A: casp16 (homo sapiens) (aka caspase 16, pseudogene)
B: tx1 (arabidopsis thaliana) (aka mate efflux family protein)
C: tx (homo sapiens) (aka caspase 4)
D: ich-2 (homo sapiens) (aka caspase 4)
E: casp-7 (homo sapiens) (aka caspase 7)
F: ice (homo s... | [C; F; F] |
<Instruct>: Given the context 'We have identified a novel cDNA encoding a protein (named TX) with > 50% overall sequence identity with the interleukin-1 beta converting enzyme (ICE) and approximately 30% sequence identity with the ICE homologs NEDD-2/ICH-1L and CED-3.', select the correct biomedical concept for each me... | <Mentions>: [tx; interleukin-1 beta converting enzyme; ice]
<Options>: A: casp1 (homo sapiens) (aka caspase 1)
B: tx (mus musculus) (aka atpase, copper transporting, beta polypeptide)
C: casp16 (homo sapiens) (aka caspase 16, pseudogene)
D: txs (homo sapiens) (aka thromboxane a synthase 1)
E: tx (homo sapiens) (aka cas... | [E; A; A] |
<Instruct>: Given the context 'We have identified a novel cDNA encoding a protein (named TX) with > 50% overall sequence identity with the interleukin-1 beta converting enzyme (ICE) and approximately 30% sequence identity with the ICE homologs NEDD-2/ICH-1L and CED-3.', select the correct biomedical concept for each me... | <Mentions>: [nedd-2; ich-1l]
<Options>: A: nedd8 (homo sapiens) (aka nedd8 ubiquitin like modifier)
B: death regulator nedd2-like caspase (drosophila melanogaster) (aka death regulator nedd2-like caspase)
C: casp-8 (homo sapiens) (aka caspase 8)
D: casp-7 (homo sapiens) (aka caspase 7)
E: casp1 (homo sapiens) (aka casp... | [H; H] |
<Instruct>: Given the context 'We have identified a novel cDNA encoding a protein (named TX) with > 50% overall sequence identity with the interleukin-1 beta converting enzyme (ICE) and approximately 30% sequence identity with the ICE homologs NEDD-2/ICH-1L and CED-3.', select the correct biomedical concept for each me... | <Mentions>: [nedd-2; ich-1l]
<Options>: A: ich-2 (homo sapiens) (aka caspase 4)
B: nedd-8 (homo sapiens) (aka nedd8 ubiquitin like modifier)
C: casp-7 (homo sapiens) (aka caspase 7)
D: nedd2 (homo sapiens) (aka caspase 2)
E: nedd3 (homo sapiens) (aka developmentally regulated gtp binding protein 1)
F: ich-3 (homo sapie... | [D; D] |
<Instruct>: Given the context 'We have identified a novel cDNA encoding a protein (named TX) with > 50% overall sequence identity with the interleukin-1 beta converting enzyme (ICE) and approximately 30% sequence identity with the ICE homologs NEDD-2/ICH-1L and CED-3.', select the correct biomedical concept for each me... | <Mentions>: [nedd-2; ich-1l]
<Options>: A: casp-7 (homo sapiens) (aka caspase 7)
B: nedd9 (homo sapiens) (aka neural precursor cell expressed, developmentally down-regulated 9)
C: nedd7 (homo sapiens) (aka dnaj heat shock protein family (hsp40) member a1)
D: casp-8 (homo sapiens) (aka caspase 8)
E: ich-3 (homo sapiens)... | [I; I] |
<Instruct>: Given the context 'A computer homology model of TX was constructed based on the X-ray coordinates of the ICE crystal recently published.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tx; ice]
<Options>: A: tx1 (xenopus laevis) (aka mab-21-like 3 s homeolog)
B: tx (homo sapiens) (aka caspase 4)
C: tx1 (xenopus tropicalis) (aka mab-21-like 3)
D: txn (xenopus laevis) (thioredoxin l homeolog (xenopus laevis)) (aka thioredoxin l homeolog)
E: ice (xenopus laevis) (caspase 1 s homeolog (xenop... | [B; G] |
<Instruct>: Given the context 'A computer homology model of TX was constructed based on the X-ray coordinates of the ICE crystal recently published.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tx; ice]
<Options>: A: txn (xenopus laevis) (thioredoxin l homeolog (xenopus laevis)) (aka thioredoxin l homeolog)
B: casp16 (homo sapiens) (aka caspase 16, pseudogene)
C: ice (homo sapiens) (caspase 1 (homo sapiens)) (aka caspase 1)
D: tx (drosophila melanogaster) (aka taxi)
E: ice(rel)iii (homo sapiens) ... | [F; C] |
<Instruct>: Given the context 'This model suggests that TX is a cysteine protease, with the P1 aspartic acid substrate specificity retained.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tx]
<Options>: A: tx (drosophila melanogaster) (aka taxi)
B: txl (homo sapiens) (aka thioredoxin like 1)
C: tx (mus musculus) (aka atpase, copper transporting, beta polypeptide)
D: tx (homo sapiens) (aka caspase 4)
E: txs (xenopus tropicalis) (aka thromboxane a synthase 1)
F: None of the above. | [D] |
<Instruct>: Given the context 'Transfection experiments demonstrate that TX is a protease which is able to cleave itself and the p30 ICE precursor, but not to generate mature IL-1 beta from pro-IL-1 beta.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [tx; ice; il-1 beta; pro-il-1 beta]
<Options>: A: casp16 (homo sapiens) (aka caspase 16, pseudogene)
B: ice(rel)iii (homo sapiens) (aka caspase 5)
C: ice (homo sapiens) (caspase 1 (homo sapiens)) (aka caspase 1)
D: tx (drosophila melanogaster) (aka taxi)
E: il-1a (homo sapiens) (aka interleukin 1 alpha)
F: ... | [F; C; H; H] |
<Instruct>: Given the context 'Transfection experiments demonstrate that TX is a protease which is able to cleave itself and the p30 ICE precursor, but not to generate mature IL-1 beta from pro-IL-1 beta.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [tx; ice; il-1 beta; pro-il-1 beta]
<Options>: A: txs (xenopus tropicalis) (aka thromboxane a synthase 1)
B: tx (mus musculus) (aka atpase, copper transporting, beta polypeptide)
C: ice2 (homo sapiens) (aka interactor of little elongation complex ell subunit 2)
D: ice(rel)ii (homo sapiens) (aka caspase 4)
E... | [G; P; N; N] |
<Instruct>: Given the context 'Transfection experiments demonstrate that TX is a protease which is able to cleave itself and the p30 ICE precursor, but not to generate mature IL-1 beta from pro-IL-1 beta.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [tx; ice; il-1 beta; pro-il-1 beta]
<Options>: A: interleukin 36 beta (homo sapiens) (aka interleukin 36 beta)
B: tx (mus musculus) (aka atpase, copper transporting, beta polypeptide)
C: ifn-beta (homo sapiens) (aka interferon beta 1)
D: ice2 (homo sapiens) (aka interactor of little elongation complex ell s... | [N; M; E; E] |
<Instruct>: Given the context 'Transfection experiments demonstrate that TX is a protease which is able to cleave itself and the p30 ICE precursor, but not to generate mature IL-1 beta from pro-IL-1 beta.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [tx; ice; il-1 beta; pro-il-1 beta]
<Options>: A: tx1 (arabidopsis thaliana) (aka mate efflux family protein)
B: il-1h (homo sapiens) (aka interleukin 37)
C: ice (homo sapiens) (caspase 1 (homo sapiens)) (aka caspase 1)
D: ifn-beta (homo sapiens) (aka interferon beta 1)
E: ich-2 (homo sapiens) (aka caspase ... | [L; C; G; G] |
<Instruct>: Given the context 'TX therefore delineates a new member of the growing Ice/ced-3 gene family coding for proteases with cytokine processing activity or involved in programmed cell death.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected option... | <Mentions>: [tx]
<Options>: A: tx1 (xenopus tropicalis) (aka mab-21-like 3)
B: txs (homo sapiens) (aka thromboxane a synthase 1)
C: txn (xenopus laevis) (thioredoxin l homeolog (xenopus laevis)) (aka thioredoxin l homeolog)
D: tx (homo sapiens) (aka caspase 4)
E: tx1 (arabidopsis thaliana) (aka mate efflux family prote... | [D] |
<Instruct>: Given the context 'The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB, is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [e48 antigen; ly-6 antigen thb]
<Options>: A: dee38 (homo sapiens) (aka arv1 fatty acid homeostasis modulator)
B: slam family member 6 (homo sapiens) (aka slam family member 6)
C: cd6 molecule (homo sapiens) (aka cd6 molecule)
D: integrin subunit beta 6 (homo sapiens) (aka integrin subunit beta 6)
E: lympho... | [H; K] |
<Instruct>: Given the context 'The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB, is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [e48 antigen; ly-6 antigen thb]
<Options>: A: el18 (homo sapiens) (aka ribosomal protein l18)
B: integrin subunit beta 6 (homo sapiens) (aka integrin subunit beta 6)
C: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
D: tnf receptor superfamily member 6b (homo sapiens) (aka tnf receptor superf... | [C; K] |
<Instruct>: Given the context 'The E48 antigen, a putative human homologue of the 20-kD protein present in desmosomal preparations of bovine muzzle, and formerly called desmoglein III (dg4), is a promising target antigen for antibody-based therapy of squamous cell carcinoma in man.', select the correct biomedical conce... | <Mentions>: [e48 antigen; desmoglein iii; dg4]
<Options>: A: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
B: mddgc4 (homo sapiens) (aka fukutin)
C: cdgs4 (homo sapiens) (aka alg3 alpha-1,3- mannosyltransferase)
D: dgk-4 (caenorhabditis elegans) (aka diacylglycerol kinase)
E: desmoglein 1 (homo sapiens)... | [A; I; I] |
<Instruct>: Given the context 'The E48 antigen, a putative human homologue of the 20-kD protein present in desmosomal preparations of bovine muzzle, and formerly called desmoglein III (dg4), is a promising target antigen for antibody-based therapy of squamous cell carcinoma in man.', select the correct biomedical conce... | <Mentions>: [e48 antigen; desmoglein iii; dg4]
<Options>: A: dsc3 (homo sapiens) (desmocollin 3 (homo sapiens)) (aka desmocollin 3)
B: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
C: cdgs4 (homo sapiens) (aka alg3 alpha-1,3- mannosyltransferase)
D: mm28 (homo sapiens) (aka matrix metallopeptidase 28)
E... | [B; O; O] |
<Instruct>: Given the context 'The E48 antigen, a putative human homologue of the 20-kD protein present in desmosomal preparations of bovine muzzle, and formerly called desmoglein III (dg4), is a promising target antigen for antibody-based therapy of squamous cell carcinoma in man.', select the correct biomedical conce... | <Mentions>: [e48 antigen; desmoglein iii; dg4]
<Options>: A: dgt4 (drosophila melanogaster) (aka dim gamma-tubulin 4)
B: mddgc4 (homo sapiens) (aka fukutin)
C: dgk-4 (caenorhabditis elegans) (aka diacylglycerol kinase)
D: desmoglein 1 (homo sapiens) (aka desmoglein 1)
E: dee48 (homo sapiens) (aka adaptor related protei... | [O; J; J] |
<Instruct>: Given the context 'A cDNA clone encoding the E48 antigen was isolated by expression cloning in COS cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e48 antigen]
<Options>: A: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
B: el18 (homo sapiens) (aka ribosomal protein l18)
C: tegument protein g48 (human gammaherpesvirus 4) (aka tegument protein g48)
D: es18 (homo sapiens) (aka programmed cell death 7)
E: dee18 (homo sapiens) (aka szt2 su... | [A] |
<Instruct>: Given the context 'Sequence analysis revealed that the clone contained an open reading frame of 128 amino acids, encoding a core protein of 13,286 kD. Database searching showed that the E48 antigen has a high level of sequence similarity with the mouse ThB antigen, a member of the Ly-6 antigen family.', sel... | <Mentions>: [e48 antigen; thb]
<Options>: A: thbd (bos taurus) (aka thrombomodulin)
B: mm28 (homo sapiens) (aka matrix metallopeptidase 28)
C: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
D: dee18 (homo sapiens) (aka szt2 subunit of kicstor complex)
E: thbs (homo sapiens) (aka thrombospondin 1)
F: tshb... | [C; G] |
<Instruct>: Given the context 'Sequence analysis revealed that the clone contained an open reading frame of 128 amino acids, encoding a core protein of 13,286 kD. Database searching showed that the E48 antigen has a high level of sequence similarity with the mouse ThB antigen, a member of the Ly-6 antigen family.', sel... | <Mentions>: [e48 antigen; thb]
<Options>: A: dee48 (homo sapiens) (aka adaptor related protein complex 3 subunit beta 2)
B: thbs (bos taurus) (aka thrombospondin 1)
C: thb (mus musculus) (aka lymphocyte antigen 6 family member d)
D: htnb (homo sapiens) (aka phosphodiesterase 3a)
E: es18 (homo sapiens) (aka programmed c... | [J; C] |
<Instruct>: Given the context 'Sequence analysis revealed that the clone contained an open reading frame of 128 amino acids, encoding a core protein of 13,286 kD. Database searching showed that the E48 antigen has a high level of sequence similarity with the mouse ThB antigen, a member of the Ly-6 antigen family.', sel... | <Mentions>: [e48 antigen; thb]
<Options>: A: tcb (homo sapiens) (aka pyruvate kinase m1/2)
B: htnb (homo sapiens) (aka phosphodiesterase 3a)
C: thb (mus musculus) (aka lymphocyte antigen 6 family member d)
D: es18 (homo sapiens) (aka programmed cell death 7)
E: dee18 (homo sapiens) (aka szt2 subunit of kicstor complex)... | [J; C] |
<Instruct>: Given the context 'Phosphatidylinositol-specific (PI-specific) phospholipase-C treatment indicated that the E48 antigen is glycosylphosphatidylinositol-anchored (GPI-anchored) to the plasma membrane.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [phosphatidylinositol-specific (pi-specific) phospholipase-c; e48 antigen]
<Options>: A: plc-ii (homo sapiens) (aka phospholipase c gamma 1)
B: plcl2 (homo sapiens) (aka phospholipase c like 2)
C: phosphatidylinositol-specific phospholipase c (glycine max) (aka phosphatidylinositol-specific phospholipase c)... | [A; E] |
<Instruct>: Given the context 'Phosphatidylinositol-specific (PI-specific) phospholipase-C treatment indicated that the E48 antigen is glycosylphosphatidylinositol-anchored (GPI-anchored) to the plasma membrane.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [phosphatidylinositol-specific (pi-specific) phospholipase-c; e48 antigen]
<Options>: A: e47 (homo sapiens) (aka transcription factor 3)
B: el18 (homo sapiens) (aka ribosomal protein l18)
C: phosphatidylinositol-specific phospholipase c (glycine max) (aka phosphatidylinositol-specific phospholipase c)
D: de... | [E; H] |
<Instruct>: Given the context 'The gene encoding the E48 antigen is a single copy gene, located on human chromosome 8 in the 8q24-qter region.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e48 antigen]
<Options>: A: dee48 (homo sapiens) (aka adaptor related protein complex 3 subunit beta 2)
B: e47 (homo sapiens) (aka transcription factor 3)
C: dee38 (homo sapiens) (aka arv1 fatty acid homeostasis modulator)
D: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
E: tegument protein ... | [D] |
<Instruct>: Given the context 'The putative mouse homologue, the ThB antigen, originally identified as an antigen on cells of the lymphocyte lineage, was shown to be highly expressed in squamous mouse epithelia.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [thb]
<Options>: A: thbd (bos taurus) (aka thrombomodulin)
B: t cell receptor beta locus (homo sapiens) (aka t cell receptor beta locus)
C: tcb (homo sapiens) (aka pyruvate kinase m1/2)
D: tshb (bos taurus) (aka thyroid stimulating hormone subunit beta)
E: thb (mus musculus) (aka lymphocyte antigen 6 family... | [E] |
<Instruct>: Given the context 'Moreover, the ThB expression level is in keratinocytes, in contrast to that in lymphocytes, not mouse strain related.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [thb]
<Options>: A: tshb (homo sapiens) (aka thyroid stimulating hormone subunit beta)
B: thbd (bos taurus) (aka thrombomodulin)
C: thbgb (homo sapiens) (aka pro-platelet basic protein)
D: htnb (homo sapiens) (aka phosphodiesterase 3a)
E: thb (mus musculus) (aka lymphocyte antigen 6 family member d)
F: None... | [E] |
<Instruct>: Given the context 'Transfection of mouse SV40-polyoma transformed mouse NIH/3T3 cells with the E48 cDNA confirmed that the antigen is likely to be involved in cell-cell adhesion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one ... | <Mentions>: [e48]
<Options>: A: e46l (homo sapiens) (aka ataxin 10)
B: dee38 (homo sapiens) (aka arv1 fatty acid homeostasis modulator)
C: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
D: nf-e4 (homo sapiens) (aka nuclear factor, erythroid 4)
E: e47 (homo sapiens) (aka transcription factor 3)
F: None of... | [C] |
<Instruct>: Given the context 'Human peroxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, se... | <Mentions>: [peroxisomal targeting signal-1 receptor]
<Options>: A: peroxisomal biogenesis factor 1 (xenopus tropicalis) (aka peroxisomal biogenesis factor 1)
B: peroxisomal targeting signal 2 receptor-like (xenopus laevis) (aka peroxisomal targeting signal 2 receptor-like)
C: sphingosine-1-phosphate receptor 1 (xenopu... | [D] |
<Instruct>: Given the context 'We have cloned and sequenced the human cDNA homologue (PTS1R) of the Pichia pastoris PAS8 gene, the PTS1 receptor (McCollum, D., E. Monosov, and S. Subramani.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [pts1r; pas8; pts1 receptor]
<Options>: A: pts1 (glycine max) (aka pterocarpan synthase)
B: pas8 (saccharomyces cerevisiae s288c) (aka aaa family atpase peroxin 6)
C: pts1r (mus musculus) (aka peroxisomal biogenesis factor 5)
D: pts1r (homo sapiens) (aka peroxisomal biogenesis factor 5)
E: neuronal pas doma... | [D; B; D] |
<Instruct>: Given the context 'We have cloned and sequenced the human cDNA homologue (PTS1R) of the Pichia pastoris PAS8 gene, the PTS1 receptor (McCollum, D., E. Monosov, and S. Subramani.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [pts1r; pas8; pts1 receptor]
<Options>: A: pts-p1 (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase pseudogene)
B: pex5r (xenopus tropicalis) (aka peroxisomal biogenesis factor 5-like)
C: pts (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase)
D: pts1-bp (homo sapiens) (aka peroxisomal biogenesis... | [D; F; D] |
<Instruct>: Given the context 'We have cloned and sequenced the human cDNA homologue (PTS1R) of the Pichia pastoris PAS8 gene, the PTS1 receptor (McCollum, D., E. Monosov, and S. Subramani.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [pts1r; pas8; pts1 receptor]
<Options>: A: pex5r (xenopus tropicalis) (aka peroxisomal biogenesis factor 5-like)
B: pas-3 (homo sapiens) (aka glycophorin b (mns blood group))
C: pts1 (glycine max) (aka pterocarpan synthase)
D: pts1-bp (homo sapiens) (aka peroxisomal biogenesis factor 5)
E: pts (homo sapiens... | [D; I; D] |
<Instruct>: Given the context 'The PTS1R mRNA is expressed in all human tissues examined.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pts1r]
<Options>: A: pts1r (rattus norvegicus) (aka peroxisomal biogenesis factor 5)
B: pts1 (glycine max) (aka pterocarpan synthase)
C: pts1r (xenopus laevis) (aka peroxisomal biogenesis factor 5 s homeolog)
D: pts-p1 (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase pseudogene)
E: pts1r (homo sapie... | [E] |
<Instruct>: Given the context 'Antibodies to the human PTS1R recognize this protein in human, monkey, rat, and hamster cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pts1r]
<Options>: A: pts1r (xenopus laevis) (aka peroxisomal biogenesis factor 5 s homeolog)
B: pts1r (homo sapiens) (aka peroxisomal biogenesis factor 5)
C: pts2r (homo sapiens) (aka peroxisomal biogenesis factor 7)
D: pts1r (rattus norvegicus) (aka peroxisomal biogenesis factor 5)
E: pts (homo sapiens) (... | [B] |
<Instruct>: Given the context 'Antibodies to the human PTS1R recognize this protein in human, monkey, rat, and hamster cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pts1r]
<Options>: A: pts1r (xenopus laevis) (aka peroxisomal biogenesis factor 5 s homeolog)
B: pts1r (rattus norvegicus) (aka peroxisomal biogenesis factor 5)
C: pts2r (homo sapiens) (aka peroxisomal biogenesis factor 7)
D: pts (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase)
E: None of the above. | [E] |
<Instruct>: Given the context 'Part of the peroxisomal PTS1R protein is tightly bound to the peroxisomal membrane.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pts1r]
<Options>: A: pts1r (homo sapiens) (aka peroxisomal biogenesis factor 5)
B: pts1r (rattus norvegicus) (aka peroxisomal biogenesis factor 5)
C: pts2r (homo sapiens) (aka peroxisomal biogenesis factor 7)
D: pts1r (xenopus laevis) (aka peroxisomal biogenesis factor 5 s homeolog)
E: pex5r (homo sapiens)... | [A] |
<Instruct>: Given the context 'Antibodies to PTS1R inhibit peroxisomal protein-import of PTS1-containing proteins in a permeabilized CHO cell system.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pts1r]
<Options>: A: pts1 (glycine max) (aka pterocarpan synthase)
B: pts2r (homo sapiens) (aka peroxisomal biogenesis factor 7)
C: pts-p1 (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase pseudogene)
D: pts1r (mus musculus) (aka peroxisomal biogenesis factor 5)
E: pts1-bp (homo sapiens) (aka peroxis... | [E] |
<Instruct>: Given the context 'In vitro-translated PTS1R protein specifically binds a serine-lysine-leucine-peptide.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pts1r]
<Options>: A: pts1 (glycine max) (aka pterocarpan synthase)
B: pex5r (homo sapiens) (aka peroxisomal biogenesis factor 5 like)
C: pts1r (rattus norvegicus) (aka peroxisomal biogenesis factor 5)
D: pts1-bp (homo sapiens) (aka peroxisomal biogenesis factor 5)
E: pts2r (homo sapiens) (aka peroxisomal b... | [D] |
<Instruct>: Given the context 'A PAS8-PTS1R fusion protein complements the P. pastoris pas8 mutant.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pas8; pts1r]
<Options>: A: pts-p1 (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase pseudogene)
B: pas3 (homo sapiens) (aka mucin 15, cell surface associated)
C: pas8 (mus musculus) (aka pulmonary adenoma susceptibility 8)
D: pts1r (xenopus laevis) (aka peroxisomal biogenesis factor 5 s homeolog)
E: ... | [F; I] |
<Instruct>: Given the context 'A PAS8-PTS1R fusion protein complements the P. pastoris pas8 mutant.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pas8; pts1r]
<Options>: A: pas8 (saccharomyces cerevisiae s288c) (aka aaa family atpase peroxin 6)
B: pasp (homo sapiens) (aka carboxypeptidase b1)
C: pts1r (rattus norvegicus) (aka peroxisomal biogenesis factor 5)
D: neuronal pas domain protein 4 (homo sapiens) (aka neuronal pas domain protein 4)
E: pts1r... | [A; E] |
<Instruct>: Given the context 'The PTS1R cDNA also complements the PTS1 protein-import defect in skin fibroblasts from patients--belonging to complementation group two--diagnosed as having neonatal adrenoleukodystrophy or Zellweger syndrome.', select the correct biomedical concept for each mention using the provided op... | <Mentions>: [pts1r]
<Options>: A: pts1r (rattus norvegicus) (aka peroxisomal biogenesis factor 5)
B: pts-p1 (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase pseudogene)
C: pts1r (xenopus laevis) (aka peroxisomal biogenesis factor 5 s homeolog)
D: pts1 (glycine max) (aka pterocarpan synthase)
E: pts1r (homo sapie... | [E] |
<Instruct>: Given the context 'The PTS1R gene has been localized to a chromosomal location where no other peroxisomal disorder genes are known to map.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [pts1r]
<Options>: A: pts1r (xenopus laevis) (aka peroxisomal biogenesis factor 5 s homeolog)
B: pts (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase)
C: pts1r (homo sapiens) (aka peroxisomal biogenesis factor 5)
D: pts2r (homo sapiens) (aka peroxisomal biogenesis factor 7)
E: pts-p1 (homo sapiens) (... | [C] |
<Instruct>: Given the context 'Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant.
TrkC is a receptor tyrosine kinase that is activated by neurotrophin-3, a factor important in the development of certain areas of the central nervous system.', select the corre... | <Mentions>: [trkc; ntrk3; neurotrophin-3]
<Options>: A: ntf3 (xenopus laevis) (neurotrophin 3 s homeolog (xenopus laevis)) (aka neurotrophin 3 s homeolog)
B: neurotrophin 3 (xenopus tropicalis) (aka neurotrophin 3)
C: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
D: ntrk3 (rattus norvegicus) (... | [H; H; F] |
<Instruct>: Given the context 'Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant.
TrkC is a receptor tyrosine kinase that is activated by neurotrophin-3, a factor important in the development of certain areas of the central nervous system.', select the corre... | <Mentions>: [trkc; ntrk3; neurotrophin-3]
<Options>: A: neurotrophin-3 (gallus gallus) (aka neurotrophin 3)
B: trka (homo sapiens) (aka neurotrophic receptor tyrosine kinase 1)
C: ntf3 (homo sapiens) (aka neurotrophin 3)
D: trkc (mus musculus) (aka neurotrophic tyrosine kinase, receptor, type 3)
E: trkc (rattus norvegi... | [F; F; C] |
<Instruct>: Given the context 'Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant.
TrkC is a receptor tyrosine kinase that is activated by neurotrophin-3, a factor important in the development of certain areas of the central nervous system.', select the corre... | <Mentions>: [trkc; ntrk3; neurotrophin-3]
<Options>: A: trkc (rattus norvegicus) (aka neurotrophic receptor tyrosine kinase 3)
B: trka (homo sapiens) (aka neurotrophic receptor tyrosine kinase 1)
C: neurotrophin-3 (gallus gallus) (aka neurotrophin 3)
D: ntrk4 (homo sapiens) (aka discoidin domain receptor tyrosine kinas... | [F; F; H] |
<Instruct>: Given the context 'We have cloned and sequenced the human trkC cDNA and found that the predicted amino acid sequence is 97 to 98% homologous to the rat and porcine trkC sequences, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selecte... | <Mentions>: [trkc]
<Options>: A: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
B: ntrk3 (homo sapiens) (aka neurotrophic receptor tyrosine kinase 3)
C: trka (homo sapiens) (aka neurotrophic receptor tyrosine kinase 1)
D: trkc (rattus norvegicus) (aka neurotrophic receptor tyrosine kinase 3)
E:... | [B] |
<Instruct>: Given the context 'The rat trkC has several isoforms due to alternative splicing in the tyrosine kinase domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trkc]
<Options>: A: trka (homo sapiens) (aka neurotrophic receptor tyrosine kinase 1)
B: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
C: ntrk2 (homo sapiens) (aka neurotrophic receptor tyrosine kinase 2)
D: trkc (mus musculus) (aka neurotrophic tyrosine kinase, receptor, type 3)
... | [E] |
<Instruct>: Given the context 'The rat trkC has several isoforms due to alternative splicing in the tyrosine kinase domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trkc]
<Options>: A: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
B: trkc (mus musculus) (aka neurotrophic tyrosine kinase, receptor, type 3)
C: ntrk2 (homo sapiens) (aka neurotrophic receptor tyrosine kinase 2)
D: trka (homo sapiens) (aka neurotrophic receptor tyrosine kinase 1)
... | [E] |
<Instruct>: Given the context 'The human trkC cDNA also has a (CGG)n repeat in the 5'-untranslated region.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trkc]
<Options>: A: trkc (homo sapiens) (aka neurotrophic receptor tyrosine kinase 3)
B: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
C: trkc (rattus norvegicus) (aka neurotrophic receptor tyrosine kinase 3)
D: trka (homo sapiens) (aka neurotrophic receptor tyrosine kinase 1)
E: ... | [A] |
<Instruct>: Given the context 'By PCR analysis of a somatic cell hybrid panel and fluorescence in situ hybridization with the cDNA clone, human trkC was mapped to chromosome 15q24-q25.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [trkc]
<Options>: A: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
B: trkc (rattus norvegicus) (aka neurotrophic receptor tyrosine kinase 3)
C: trkc (mus musculus) (aka neurotrophic tyrosine kinase, receptor, type 3)
D: trkb (homo sapiens) (aka neurotrophic receptor tyrosine kinase... | [E] |
<Instruct>: Given the context 'Fibulin-2 (FBLN2): human cDNA sequence, mRNA expression, and mapping of the gene on human and mouse chromosomes.
Fibulin-2 is a new extracellular matrix protein that we recently identified by characterizing mouse cDNA clones.', select the correct biomedical concept for each mention using ... | <Mentions>: [fibulin-2; fbln2]
<Options>: A: fbln2 (bos taurus) (aka fibulin 2)
B: fbln2 (sus scrofa) (aka fibulin 2)
C: fibulin 1 (homo sapiens) (aka fibulin 1)
D: fibulin 2 (sus scrofa) (aka fibulin 2)
E: egf containing fibulin extracellular matrix protein 2 (homo sapiens) (aka egf containing fibulin extracellular ma... | [G; G] |
<Instruct>: Given the context 'Fibulin-2 (FBLN2): human cDNA sequence, mRNA expression, and mapping of the gene on human and mouse chromosomes.
Fibulin-2 is a new extracellular matrix protein that we recently identified by characterizing mouse cDNA clones.', select the correct biomedical concept for each mention using ... | <Mentions>: [fibulin-2; fbln2]
<Options>: A: egf containing fibulin extracellular matrix protein 2 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 2)
B: fbln2 (bos taurus) (aka fibulin 2)
C: fibulin 2 (sus scrofa) (aka fibulin 2)
D: fibulin 1 (homo sapiens) (aka fibulin 1)
E: fbln3 (homo sapiens... | [F; F] |
<Instruct>: Given the context 'Fibulin-2 mRNA is prominently expressed in mouse heart tissue and is present in low amounts in other tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fibulin-2]
<Options>: A: fbln2 (homo sapiens) (aka fibulin 2)
B: egf containing fibulin extracellular matrix protein 1 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 1)
C: fibulin 2 (sus scrofa) (aka fibulin 2)
D: egf containing fibulin extracellular matrix protein 2 (homo sapiens)... | [A] |
<Instruct>: Given the context 'In this study, we isolated and sequenced a 4.1-kb human fibulin-2 cDNA, which encoded a mature protein of 1157 amino acids preceded by a 27-residue signal sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options,... | <Mentions>: [fibulin-2]
<Options>: A: fibulin 2 (homo sapiens) (aka fibulin 2)
B: fibulin 2 (sus scrofa) (aka fibulin 2)
C: fibulin 1 (homo sapiens) (aka fibulin 1)
D: egf containing fibulin extracellular matrix protein 2 (sus scrofa) (aka egf containing fibulin extracellular matrix protein 2)
E: egf containing fibulin... | [A] |
<Instruct>: Given the context 'The 115-residue C-terminal segment (domain III) is similar to the C variant of fibulin-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fibulin-1]
<Options>: A: fib1 (homo sapiens) (aka dachsous cadherin-related 1)
B: fibrillin 1 (homo sapiens) (aka fibrillin 1)
C: egf containing fibulin extracellular matrix protein 1 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 1)
D: fibulin-1 (caenorhabditis elegans) (aka fibul... | [E] |
<Instruct>: Given the context 'The amino acid sequences of the human and mouse fibulin-2 share approximately 90% identity in domains Na, I, II, and III but only 62% identity in domain Nb.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [fibulin-2]
<Options>: A: egf containing fibulin extracellular matrix protein 2 (sus scrofa) (aka egf containing fibulin extracellular matrix protein 2)
B: fibulin 1 (homo sapiens) (aka fibulin 1)
C: fibin (homo sapiens) (aka fin bud initiation factor homolog)
D: fibulin 2 (homo sapiens) (aka fibulin 2)
E: ... | [D] |
<Instruct>: Given the context 'The amino acid sequences of the human and mouse fibulin-2 share approximately 90% identity in domains Na, I, II, and III but only 62% identity in domain Nb.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [fibulin-2]
<Options>: A: fibin (homo sapiens) (aka fin bud initiation factor homolog)
B: fibulin 1 (homo sapiens) (aka fibulin 1)
C: egf containing fibulin extracellular matrix protein 2 (sus scrofa) (aka egf containing fibulin extracellular matrix protein 2)
D: egf containing fibulin extracellular matrix ... | [E] |
<Instruct>: Given the context 'The expression pattern differs from that of fibulin-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fibulin-1]
<Options>: A: fibulin 2 (homo sapiens) (aka fibulin 2)
B: fbln1 (homo sapiens) (aka fibulin 1)
C: egf containing fibulin extracellular matrix protein 1 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 1)
D: fib1 (homo sapiens) (aka dachsous cadherin-related 1)
E: fibulin 5... | [B] |
<Instruct>: Given the context 'The fibulin-2 gene was localized by in situ hybridization to the p24-p25 region of human chromosome 3 and to the band D-E of mouse chromosome 6.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [fibulin-2]
<Options>: A: fibulin 2 (sus scrofa) (aka fibulin 2)
B: egf containing fibulin extracellular matrix protein 2 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 2)
C: fibin (homo sapiens) (aka fin bud initiation factor homolog)
D: fibulin 2 (homo sapiens) (aka fibulin 2)
E: ... | [D] |
<Instruct>: Given the context 'TFIID is a multisubunit protein complex comprised of the TATA-binding protein (TBP) and multiple TBP-associated factors (TAFs).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [tata-binding protein; tbp]
<Options>: A: tata-box binding protein (bos taurus) (aka tata-box binding protein)
B: tata-box binding protein (homo sapiens) (aka tata-box binding protein)
C: tata-box binding protein like 1 (bos taurus) (aka tata-box binding protein like 1)
D: tbp-b (xenopus tropicalis) (aka ta... | [B; B] |
<Instruct>: Given the context 'TFIID is a multisubunit protein complex comprised of the TATA-binding protein (TBP) and multiple TBP-associated factors (TAFs).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [tata-binding protein; tbp]
<Options>: A: rbp (drosophila melanogaster) (tata binding protein (drosophila melanogaster)) (aka tata binding protein)
B: tbp protein-like pseudogene (bos taurus) (aka tbp protein-like pseudogene)
C: tata-box binding protein like 1 (bos taurus) (aka tata-box binding protein like... | [D; D] |
<Instruct>: Given the context 'The cloning of a complementary DNA encoding a human TFIID TAF, TAFII55, that has no known homolog in Drosophila TFIID is now described.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [tafii55]
<Options>: A: tafii55 (xenopus laevis) (aka tata-box binding protein associated factor 7 l homeolog)
B: tafii-32 (homo sapiens) (aka tata-box binding protein associated factor 9)
C: tafii55 (homo sapiens) (aka tata-box binding protein associated factor 7)
D: tafii55 (xenopus tropicalis) (aka tata-... | [C] |
<Instruct>: Given the context 'TAFII55 is shown to interact with the largest subunit (TAFII230) of human TFIID through its central region and with multiple activators--including Sp1, YY1, USF, CTF, adenoviral E1A, and human immunodeficiency virus-type 1 Tat proteins--through a distinct amino-terminal domain.', select t... | <Mentions>: [tafii55; tafii230; sp1; yy1]
<Options>: A: taf[[ii]] (drosophila melanogaster) (tbp-associated factor 5 (drosophila melanogaster)) (aka tbp-associated factor 5)
B: taf10 (saccharomyces cerevisiae s288c) (aka taf10p)
C: yy1 (drosophila melanogaster) (aka pleiohomeotic)
D: tafii30 (homo sapiens) (aka tata-bo... | [P; N; L; O] |
<Instruct>: Given the context 'TAFII55 is shown to interact with the largest subunit (TAFII230) of human TFIID through its central region and with multiple activators--including Sp1, YY1, USF, CTF, adenoviral E1A, and human immunodeficiency virus-type 1 Tat proteins--through a distinct amino-terminal domain.', select t... | <Mentions>: [tafii55; tafii230; sp1; yy1]
<Options>: A: yy1 (xenopus laevis) (yy1 transcription factor l homeolog (xenopus laevis)) (aka yy1 transcription factor l homeolog)
B: tafii-32 (homo sapiens) (aka tata-box binding protein associated factor 9)
C: tafii30 (homo sapiens) (aka tata-box binding protein associated f... | [F; H; P; Q] |
<Instruct>: Given the context 'TAFII55 is shown to interact with the largest subunit (TAFII230) of human TFIID through its central region and with multiple activators--including Sp1, YY1, USF, CTF, adenoviral E1A, and human immunodeficiency virus-type 1 Tat proteins--through a distinct amino-terminal domain.', select t... | <Mentions>: [tafii55; tafii230; sp1; yy1]
<Options>: A: mt-sp1 (homo sapiens) (aka st14 transmembrane serine protease matriptase)
B: yy1p1 (homo sapiens) (aka yy1 transcription factor pseudogene 1)
C: sp1 transcription factor (bos taurus) (aka sp1 transcription factor)
D: yin-yang-1 (homo sapiens) (aka yy1 transcriptio... | [E; N; M; D] |
<Instruct>: Given the context 'TAFII55 is shown to interact with the largest subunit (TAFII230) of human TFIID through its central region and with multiple activators--including Sp1, YY1, USF, CTF, adenoviral E1A, and human immunodeficiency virus-type 1 Tat proteins--through a distinct amino-terminal domain.', select t... | <Mentions>: [tafii55; tafii230; sp1; yy1]
<Options>: A: tafii-250 (homo sapiens) (aka tata-box binding protein associated factor 1)
B: yy1p1 (homo sapiens) (aka yy1 transcription factor pseudogene 1)
C: tafii55 (homo sapiens) (aka tata-box binding protein associated factor 7)
D: h-sp1 (homo sapiens) (aka synaptophysin ... | [C; A; O; T] |
<Instruct>: Given the context 'TAFII55 is shown to interact with the largest subunit (TAFII230) of human TFIID through its central region and with multiple activators--including Sp1, YY1, USF, CTF, adenoviral E1A, and human immunodeficiency virus-type 1 Tat proteins--through a distinct amino-terminal domain.', select t... | <Mentions>: [usf]
<Options>: A: usf1 (mus musculus) (aka upstream transcription factor 1)
B: usf3 (homo sapiens) (aka upstream transcription factor family member 3)
C: usf1 (homo sapiens) (aka upstream transcription factor 1)
D: ush1f (homo sapiens) (aka protocadherin related 15)
E: usf (drosophila melanogaster) (aka u... | [C] |
<Instruct>: Given the context 'The TAFII55-interacting region of Sp1 was localized to its DNA-binding domain, which is distinct from the glutamine-rich activation domains previously shown to interact with Drosophila TAFII110.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [tafii55; sp1; tafii110]
<Options>: A: tafii170 (homo sapiens) (aka b-tfiid tata-box binding protein associated factor 1)
B: sp1 transcription factor (bos taurus) (aka sp1 transcription factor)
C: sp1 transcription factor (xenopus tropicalis) (aka sp1 transcription factor)
D: taf30 (saccharomyces cerevisiae... | [N; F; P] |
<Instruct>: Given the context 'The TAFII55-interacting region of Sp1 was localized to its DNA-binding domain, which is distinct from the glutamine-rich activation domains previously shown to interact with Drosophila TAFII110.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [tafii55; sp1; tafii110]
<Options>: A: tafii-140 (homo sapiens) (aka tata-box binding protein associated factor 3)
B: tafii-32 (homo sapiens) (aka tata-box binding protein associated factor 9)
C: tafii170 (homo sapiens) (aka b-tfiid tata-box binding protein associated factor 1)
D: tafii55 (homo sapiens) (ak... | [D; H; P] |
<Instruct>: Given the context 'The TAFII55-interacting region of Sp1 was localized to its DNA-binding domain, which is distinct from the glutamine-rich activation domains previously shown to interact with Drosophila TAFII110.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [tafii55; sp1; tafii110]
<Options>: A: tafii70 (homo sapiens) (aka tata-box binding protein associated factor 6)
B: taf65 (saccharomyces cerevisiae s288c) (aka taf8p)
C: t-sp1 (homo sapiens) (aka serine protease 55)
D: tafii-32 (homo sapiens) (aka tata-box binding protein associated factor 9)
E: taf2 (sacch... | [O; N; O] |
<Instruct>: Given the context 'The TAFII55-interacting region of Sp1 was localized to its DNA-binding domain, which is distinct from the glutamine-rich activation domains previously shown to interact with Drosophila TAFII110.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [tafii55; sp1; tafii110]
<Options>: A: sp1 transcription factor (homo sapiens) (aka sp1 transcription factor)
B: tafii68 (homo sapiens) (aka tata-box binding protein associated factor 15)
C: taf[[ii]] (drosophila melanogaster) (tbp-associated factor 5 (drosophila melanogaster)) (aka tbp-associated factor 5)... | [D; A; P] |
<Instruct>: Given the context 'ERGIC-53, a membrane protein of the endoplasmic reticulum-Golgi intermediate compartment, is identical to MR60, an intracellular mannose-specific lectin of myelomonocytic cells.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the sel... | <Mentions>: [ergic-53; mr60]
<Options>: A: ergic53 (drosophila melanogaster) (aka ergic53)
B: cg6060 (drosophila melanogaster) (aka uncharacterized protein)
C: er60 (homo sapiens) (aka protein disulfide isomerase family a member 3)
D: ergic-53l (homo sapiens) (aka lectin, mannose binding 1 like)
E: ergic53 (homo sapien... | [E; E] |
<Instruct>: Given the context 'ERGIC-53, a membrane protein of the endoplasmic reticulum-Golgi intermediate compartment, is identical to MR60, an intracellular mannose-specific lectin of myelomonocytic cells.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the sel... | <Mentions>: [ergic-53; mr60]
<Options>: A: mic60 (homo sapiens) (aka inner membrane mitochondrial protein)
B: hel60 (homo sapiens) (aka aconitase 1)
C: ergic53 (homo sapiens) (aka lectin, mannose binding 1)
D: ergic-63 (homo sapiens) (aka cytoskeleton associated protein 4)
E: ergic-53l (mus musculus) (aka complexin 3)
... | [C; C] |
<Instruct>: Given the context 'A mannose-specific membrane lectin (MR60) isolated from human myelomonocytic HL60 cells by affinity chromatography is expressed in intracellular organelles of immature monocytes (Pimpaneau, V., Midoux, P., Monsigny, M., and Roche, A. C. (1991) Carbohydr.', select the correct biomedical co... | <Mentions>: [mr60]
<Options>: A: mic60 (homo sapiens) (aka inner membrane mitochondrial protein)
B: cg6060 (drosophila melanogaster) (aka uncharacterized protein)
C: mrt60 (homo sapiens) (aka tata-box binding protein associated factor 13)
D: ro60 (homo sapiens) (aka ro60, y rna binding protein)
E: mr60 (homo sapiens) (... | [E] |
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