instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Previous studies have specifically implicated DNA polymerase delta as the enzyme involved in DNA repair synthesis occurring immediately after UV damage.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [dna polymerase delta]
<Options>: A: dna polymerase iii subunit delta (escherichia coli str. k-12 substr. mg1655) (aka dna polymerase iii subunit delta)
B: dna polymerase theta (homo sapiens) (aka dna polymerase theta)
C: cdc2 (homo sapiens) (dna polymerase delta 1, catalytic subunit (homo sapiens)) (aka dn... | [C] |
<Instruct>: Given the context 'In permeable cells, the process was further analyzed by using the nucleotide analogue (butylphenyl)-2'-deoxyguanosine 5'-triphosphate, which inhibits DNA polymerase alpha several hundred times more strongly than it inhibits DNA polymerase delta.', select the correct biomedical concept for... | <Mentions>: [dna polymerase alpha; dna polymerase delta]
<Options>: A: dna polymerase delta 1, catalytic subunit (homo sapiens) (aka dna polymerase delta 1, catalytic subunit)
B: dna polymerase catalytic subunit (human alphaherpesvirus 1) (aka dna polymerase catalytic subunit)
C: cdc2 (homo sapiens) (dna polymerase del... | [F; C] |
<Instruct>: Given the context 'In permeable cells, the process was further analyzed by using the nucleotide analogue (butylphenyl)-2'-deoxyguanosine 5'-triphosphate, which inhibits DNA polymerase alpha several hundred times more strongly than it inhibits DNA polymerase delta.', select the correct biomedical concept for... | <Mentions>: [dna polymerase alpha; dna polymerase delta]
<Options>: A: dna polymerase eta (homo sapiens) (aka dna polymerase eta)
B: dna polymerase catalytic subunit (human alphaherpesvirus 1) (aka dna polymerase catalytic subunit)
C: dna polymerase epsilon, catalytic subunit (homo sapiens) (aka dna polymerase epsilon,... | [D; H] |
<Instruct>: Given the context 'The (butylphenyl)-2'-deoxyguanosine 5'-triphosphate inhibition curve for late UV-induced repair synthesis was very similar to that for polymerase delta.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [polymerase delta]
<Options>: A: pold (homo sapiens) (aka dna polymerase delta 1, catalytic subunit)
B: dna polymerase iii subunit delta (escherichia coli str. k-12 substr. mg1655) (aka dna polymerase iii subunit delta)
C: dna polymerase delta catalytic subunit (caenorhabditis elegans) (aka dna polymerase d... | [A] |
<Instruct>: Given the context 'The (butylphenyl)-2'-deoxyguanosine 5'-triphosphate inhibition curve for late UV-induced repair synthesis was very similar to that for polymerase delta.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [polymerase delta]
<Options>: A: dna polymerase epsilon, catalytic subunit (homo sapiens) (aka dna polymerase epsilon, catalytic subunit)
B: dna polymerase delta 3, accessory subunit (homo sapiens) (aka dna polymerase delta 3, accessory subunit)
C: dna polymerase iii subunit delta (escherichia coli str. k-1... | [E] |
<Instruct>: Given the context 'It appears that repair synthesis at late times after UV irradiation, like repair synthesis at early times, is mediated by DNA polymerase delta.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [dna polymerase delta]
<Options>: A: dna polymerase delta 3, accessory subunit (homo sapiens) (aka dna polymerase delta 3, accessory subunit)
B: dna polymerase iota (homo sapiens) (aka dna polymerase iota)
C: dna polymerase delta 2, accessory subunit (homo sapiens) (aka dna polymerase delta 2, accessory sub... | [D] |
<Instruct>: Given the context 'Molecular cloning and primary structure of human 15-lipoxygenase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [15-lipoxygenase]
<Options>: A: arachidonate 15-lipoxygenase type b (homo sapiens) (aka arachidonate 15-lipoxygenase type b)
B: arachidonate 15-lipoxygenase (rattus norvegicus) (aka arachidonate 15-lipoxygenase)
C: 15-lox (oryctolagus cuniculus) (aka arachidonate 15-lipoxygenase)
D: arachidonate 15-lipoxyge... | [D] |
<Instruct>: Given the context 'A full-length cDNA encoding 15-lipoxygenase has been isolated from a human reticulocyte cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [15-lipoxygenase]
<Options>: A: arachidonate 15-lipoxygenase (rattus norvegicus) (aka arachidonate 15-lipoxygenase)
B: 15-lox (oryctolagus cuniculus) (aka arachidonate 15-lipoxygenase)
C: 12-lox (homo sapiens) (arachidonate 15-lipoxygenase (homo sapiens)) (aka arachidonate 15-lipoxygenase)
D: arachidonate 1... | [C] |
<Instruct>: Given the context 'The predicted primary structure of the enzyme exhibits a sequence similarity of 61% and 45% with human 5-lipoxygenase and the soybean lipoxygenase isoenzyme I, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [5-lipoxygenase; lipoxygenase isoenzyme i]
<Options>: A: lox1 (homo sapiens) (aka oxidized low density lipoprotein receptor 1)
B: linoleate 9s-lipoxygenase 1 (glycine max) (aka linoleate 9s-lipoxygenase 1)
C: loxl1 (homo sapiens) (aka lysyl oxidase like 1)
D: lipoxygenase l-5 (glycine max) (aka lipoxygenase... | [G; J] |
<Instruct>: Given the context 'The predicted primary structure of the enzyme exhibits a sequence similarity of 61% and 45% with human 5-lipoxygenase and the soybean lipoxygenase isoenzyme I, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [5-lipoxygenase; lipoxygenase isoenzyme i]
<Options>: A: lipoxygenase l-5 (glycine max) (aka lipoxygenase l-5)
B: 15-lox (homo sapiens) (aka arachidonate 15-lipoxygenase)
C: linoleate 9s-lipoxygenase 1 (glycine max) (aka linoleate 9s-lipoxygenase 1)
D: arachidonate 5-lipoxygenase (oryctolagus cuniculus) (ak... | [G; K] |
<Instruct>: Given the context 'Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [srf; c-fos]
<Options>: A: fosl1 (homo sapiens) (aka fos like 1, ap-1 transcription factor subunit)
B: fos (homo sapiens) (aka fos proto-oncogene, ap-1 transcription factor subunit)
C: srf-1 (homo sapiens) (aka spermatogenesis associated 6)
D: serum response factor (sus scrofa) (aka serum response factor)
E... | [H; B] |
<Instruct>: Given the context 'Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [srf; c-fos]
<Options>: A: serum response factor homolog b (glycine max) (aka serum response factor homolog b)
B: c-fos (xenopus tropicalis) (aka fbj murine osteosarcoma viral oncogene homolog)
C: fos proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka fos proto-oncogene, ap-1 transcriptio... | [J; C] |
<Instruct>: Given the context 'We have isolated cDNA clones encoding serum response factor (SRF), a ubiquitous nuclear protein that binds to the SRE.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [serum response factor; srf]
<Options>: A: serum response factor (homo sapiens) (aka serum response factor)
B: srf (sus scrofa) (aka serum response factor)
C: serum response factor (xenopus tropicalis) (aka serum response factor)
D: srf (mus musculus) (aka serum response factor)
E: serum response factor (su... | [A; A] |
<Instruct>: Given the context 'We have isolated cDNA clones encoding serum response factor (SRF), a ubiquitous nuclear protein that binds to the SRE.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [serum response factor; srf]
<Options>: A: srf (mus musculus) (aka serum response factor)
B: serum response factor (bos taurus) (aka serum response factor)
C: serum response factor (sus scrofa) (aka serum response factor)
D: serum response factor homolog (caenorhabditis elegans) (aka serum response factor h... | [I; I] |
<Instruct>: Given the context 'The SRF gene is highly conserved through evolution, and in cultured cells its transcription is itself transiently increased following serum stimulation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [srf]
<Options>: A: serum response factor homolog (caenorhabditis elegans) (aka serum response factor homolog)
B: srf (mus musculus) (aka serum response factor)
C: serum response factor (sus scrofa) (aka serum response factor)
D: serum response factor (homo sapiens) (aka serum response factor)
E: serum resp... | [D] |
<Instruct>: Given the context 'A cDNA clone of SRF expressed in vitro generates protein that forms complexes indistinguishable from those formed with HeLa cell SRF, as judged by DNA binding specificity and the ability to promote SRE-dependent in vitro transcription.', select the correct biomedical concept for each ment... | <Mentions>: [srf]
<Options>: A: serum response factor (homo sapiens) (aka serum response factor)
B: serum response factor homolog (caenorhabditis elegans) (aka serum response factor homolog)
C: srf1 (homo sapiens) (aka spermatogenesis associated 6)
D: serum response factor (xenopus tropicalis) (aka serum response facto... | [A] |
<Instruct>: Given the context 'SRF binds DNA as a dimer, and the DNA binding/dimerization domain of the protein exhibits striking homology to two yeast regulatory proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [srf]
<Options>: A: serum response factor (xenopus tropicalis) (aka serum response factor)
B: serum response factor homolog (caenorhabditis elegans) (aka serum response factor homolog)
C: srf-1 (homo sapiens) (aka spermatogenesis associated 6)
D: srf (sus scrofa) (aka serum response factor)
E: serum respons... | [E] |
<Instruct>: Given the context 'Isolation of cDNA clones coding for rat isovaleryl-CoA dehydrogenase and assignment of the gene to human chromosome 15.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [isovaleryl-coa dehydrogenase]
<Options>: A: isovaleryl-coa dehydrogenase (oryctolagus cuniculus) (aka isovaleryl-coa dehydrogenase)
B: isovaleryl-coa dehydrogenase (homo sapiens) (aka isovaleryl-coa dehydrogenase)
C: isovaleryl-coa dehydrogenase (rattus norvegicus) (aka isovaleryl-coa dehydrogenase)
D: iso... | [C] |
<Instruct>: Given the context 'Rat liver mRNA encoding the cytoplasmic precursor of mitochondrial isovaleryl-CoA dehydrogenase was highly enriched by polysome immunopurification using a polyclonal monospecific antibody.', select the correct biomedical concept for each mention using the provided options. Answer by listi... | <Mentions>: [isovaleryl-coa dehydrogenase]
<Options>: A: isovaleryl-coa dehydrogenase (oryctolagus cuniculus) (aka isovaleryl-coa dehydrogenase)
B: isovaleryl-coa dehydrogenase (gallus gallus) (aka isovaleryl-coa dehydrogenase)
C: isovaleryl-coa dehydrogenase (rattus norvegicus) (aka isovaleryl-coa dehydrogenase)
D: is... | [C] |
<Instruct>: Given the context 'Rat liver mRNA encoding the cytoplasmic precursor of mitochondrial isovaleryl-CoA dehydrogenase was highly enriched by polysome immunopurification using a polyclonal monospecific antibody.', select the correct biomedical concept for each mention using the provided options. Answer by listi... | <Mentions>: [isovaleryl-coa dehydrogenase]
<Options>: A: isovaleryl coenzyme a dehydrogenase (mus musculus) (aka isovaleryl coenzyme a dehydrogenase)
B: isovaleryl-coa dehydrogenase (oryctolagus cuniculus) (aka isovaleryl-coa dehydrogenase)
C: isovaleryl-coa dehydrogenase (gallus gallus) (aka isovaleryl-coa dehydrogena... | [E] |
<Instruct>: Given the context 'The purified mRNA was used to prepare a plasmid cDNA library which was screened with two oligonucleotide mixtures encoding two peptides in the amino-terminal portion of mature rat isovaleryl-CoA dehydrogenase.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [isovaleryl-coa dehydrogenase]
<Options>: A: isovaleryl-coa dehydrogenase (rattus norvegicus) (aka isovaleryl-coa dehydrogenase)
B: acyl-coa dehydrogenase very long chain (bos taurus) (aka acyl-coa dehydrogenase very long chain)
C: isovaleryl-coa dehydrogenase (xenopus tropicalis) (aka isovaleryl-coa dehydr... | [A] |
<Instruct>: Given the context 'Southern blot analysis of DNAs from human-rodent somatic cell hybrids with an isolated rat cDNA (2 kbp) assigned the isovaleryl-CoA dehydrogenase gene to the long arm of chromosome 15, region q14----qter.', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [isovaleryl-coa dehydrogenase]
<Options>: A: isovaleryl coenzyme a dehydrogenase (mus musculus) (aka isovaleryl coenzyme a dehydrogenase)
B: isovaleryl-coa dehydrogenase (oryctolagus cuniculus) (aka isovaleryl-coa dehydrogenase)
C: isovaleryl-coa dehydrogenase (sus scrofa) (aka isovaleryl-coa dehydrogenase)... | [E] |
<Instruct>: Given the context 'This location differs from that of the gene for medium-chain acyl-CoA dehydrogenase, a closely related enzyme, which has been previously assigned to chromosome 1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [medium-chain acyl-coa dehydrogenase]
<Options>: A: acyl-coa dehydrogenase medium chain (homo sapiens) (aka acyl-coa dehydrogenase medium chain)
B: acyl-coa dehydrogenase medium chain (sus scrofa) (aka acyl-coa dehydrogenase medium chain)
C: mcad (mus musculus) (acyl-coenzyme a dehydrogenase, medium chain (... | [A] |
<Instruct>: Given the context 'Molecular cloning of a cDNA for human delta-aminolevulinate dehydratase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [delta-aminolevulinate dehydratase]
<Options>: A: aminolevulinate dehydratase s homeolog (xenopus laevis) (aka aminolevulinate dehydratase s homeolog)
B: aminolevulinate dehydratase (xenopus tropicalis) (aka aminolevulinate dehydratase)
C: aminolevulinate dehydratase (bos taurus) (aka aminolevulinate dehydr... | [E] |
<Instruct>: Given the context 'A cDNA encoding human delta-aminolevulinic acid dehydratase (ALA-D; EC 4.2.1.24), the second enzyme in the heme biosynthetic pathway, was isolated from a human liver cDNA expression library.', select the correct biomedical concept for each mention using the provided options. Answer by lis... | <Mentions>: [delta-aminolevulinic acid dehydratase; ala-d]
<Options>: A: aminolevulinate dehydratase l homeolog (xenopus laevis) (aka aminolevulinate dehydratase l homeolog)
B: delta-aminolevulinic acid dehydratase, chloroplastic-like (glycine max) (aka delta-aminolevulinic acid dehydratase, chloroplastic-like)
C: alad... | [G; G] |
<Instruct>: Given the context 'A cDNA encoding human delta-aminolevulinic acid dehydratase (ALA-D; EC 4.2.1.24), the second enzyme in the heme biosynthetic pathway, was isolated from a human liver cDNA expression library.', select the correct biomedical concept for each mention using the provided options. Answer by lis... | <Mentions>: [delta-aminolevulinic acid dehydratase; ala-d]
<Options>: A: aminolevulinate dehydratase s homeolog (xenopus laevis) (aka aminolevulinate dehydratase s homeolog)
B: alad (xenopus laevis) (aka aminolevulinate dehydratase l homeolog)
C: aminolevulinate dehydratase (homo sapiens) (aka aminolevulinate dehydrata... | [C; C] |
<Instruct>: Given the context 'Of the original 17 clones selected with anti-ALA-D antibody, only four expressed anti-ALA-D epitopes as assessed by rescreening with antibody preabsorbed with purified antigen.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [ala-d]
<Options>: A: aaopd (homo sapiens) (aka parkinson disease 10 (susceptibility))
B: aard (homo sapiens) (aka alanine and arginine rich domain containing protein)
C: alad (xenopus laevis) (aka aminolevulinate dehydratase l homeolog)
D: alad.s (xenopus laevis) (aka aminolevulinate dehydratase s homeolog... | [E] |
<Instruct>: Given the context 'The aa sequence predicted from the partial nucleotide sequence was found to be essentially colinear with the sequences of four bovine ALA-D peptides, totaling 35 non-overlapping aa residues.', select the correct biomedical concept for each mention using the provided options. Answer by lis... | <Mentions>: [ala-d]
<Options>: A: aaopd (homo sapiens) (aka parkinson disease 10 (susceptibility))
B: aladin (homo sapiens) (aka aladin wd repeat nucleoporin)
C: alad (glycine max) (aka aminolevulinate, delta-, dehydratase)
D: aard (homo sapiens) (aka alanine and arginine rich domain containing protein)
E: alad.s (xeno... | [F] |
<Instruct>: Given the context '6-Phosphogluconolactonase deficiency, a hereditary erythrocyte enzyme deficiency: possible interaction with glucose-6-phosphate dehydrogenase deficiency.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for e... | <Mentions>: [6-phosphogluconolactonase; glucose-6-phosphate dehydrogenase]
<Options>: A: 6-phosphogluconolactonase (escherichia coli str. k-12 substr. mg1655) (aka 6-phosphogluconolactonase)
B: 6-phosphogluconolactonase (bos taurus) (aka 6-phosphogluconolactonase)
C: glucose-6-phosphate dehydrogenase (danio rerio) (aka... | [G; D] |
<Instruct>: Given the context '6-Phosphogluconolactonase deficiency, a hereditary erythrocyte enzyme deficiency: possible interaction with glucose-6-phosphate dehydrogenase deficiency.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for e... | <Mentions>: [6-phosphogluconolactonase; glucose-6-phosphate dehydrogenase]
<Options>: A: 6-phosphogluconolactonase (bos taurus) (aka 6-phosphogluconolactonase)
B: 6-phosphogluconolactonase (xenopus tropicalis) (aka 6-phosphogluconolactonase)
C: 6-phosphogluconolactonase (homo sapiens) (aka 6-phosphogluconolactonase)
D:... | [C; I] |
<Instruct>: Given the context 'Partial deficiency of 6-phosphogluconolactonase (EC 3.1.1.31) of the erythrocytes was discovered as an autosomal dominant disorder.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [6-phosphogluconolactonase]
<Options>: A: 6-phosphogluconolactonase (homo sapiens) (aka 6-phosphogluconolactonase)
B: 6-phosphogluconolactonase (xenopus tropicalis) (aka 6-phosphogluconolactonase)
C: 6-phosphogluconolactonase (gallus gallus) (aka 6-phosphogluconolactonase)
D: 6-phosphogluconolactonase (bos ... | [A] |
<Instruct>: Given the context 'Hemolytic anemia occurred in an individual who had inherited both the gene for 6-phosphogluconolactonase deficiency and that for deficiency of a nonhemolytic variant of glucose-6-phosphate dehydrogenase (EC 1.1.1.49).', select the correct biomedical concept for each mention using the prov... | <Mentions>: [6-phosphogluconolactonase; glucose-6-phosphate dehydrogenase]
<Options>: A: glucose-6-phosphate dehydrogenase (sus scrofa) (aka glucose-6-phosphate dehydrogenase)
B: g6pd (homo sapiens) (glucose-6-phosphate dehydrogenase (homo sapiens)) (aka glucose-6-phosphate dehydrogenase)
C: 6-phosphogluconolactonase (... | [F; B] |
<Instruct>: Given the context 'Hemolytic anemia occurred in an individual who had inherited both the gene for 6-phosphogluconolactonase deficiency and that for deficiency of a nonhemolytic variant of glucose-6-phosphate dehydrogenase (EC 1.1.1.49).', select the correct biomedical concept for each mention using the prov... | <Mentions>: [6-phosphogluconolactonase; glucose-6-phosphate dehydrogenase]
<Options>: A: glucose-6-phosphate 1-dehydrogenase (caenorhabditis elegans) (aka glucose-6-phosphate 1-dehydrogenase)
B: 6-phosphogluconolactonase (homo sapiens) (aka 6-phosphogluconolactonase)
C: 6pgd (homo sapiens) (aka phosphogluconate dehydro... | [B; F] |
<Instruct>: Given the context 'It is proposed that the interaction of this hereditary erythrocyte abnormality with glucose-6-phosphate dehydrogenase deficiency may explain hemolysis in some other patients who have inherited polymorphic variants of glucose-6-phosphate dehydrogenase.', select the correct biomedical conce... | <Mentions>: [glucose-6-phosphate dehydrogenase]
<Options>: A: 6pgd (homo sapiens) (aka phosphogluconate dehydrogenase)
B: glucose-6-phosphate dehydrogenase (sus scrofa) (aka glucose-6-phosphate dehydrogenase)
C: glucose-6-phosphate 1-dehydrogenase (caenorhabditis elegans) (aka glucose-6-phosphate 1-dehydrogenase)
D: ud... | [E] |
<Instruct>: Given the context 'It is proposed that the interaction of this hereditary erythrocyte abnormality with glucose-6-phosphate dehydrogenase deficiency may explain hemolysis in some other patients who have inherited polymorphic variants of glucose-6-phosphate dehydrogenase.', select the correct biomedical conce... | <Mentions>: [glucose-6-phosphate dehydrogenase]
<Options>: A: glucose-6-phosphate dehydrogenase (sus scrofa) (aka glucose-6-phosphate dehydrogenase)
B: 6pgd (homo sapiens) (aka phosphogluconate dehydrogenase)
C: glucose-6-phosphate 1-dehydrogenase (caenorhabditis elegans) (aka glucose-6-phosphate 1-dehydrogenase)
D: ud... | [E] |
<Instruct>: Given the context 'Human muscle phosphoglycerate mutase deficiency: newly discovered metabolic myopathy.
Muscle phosphoglycerate mutase activity was decreased (5.7 percent of the lowest control value) in a 52-year-old man with intolerance for strenuous exercise and recurrent pigmenturia since adolescence.',... | <Mentions>: [muscle phosphoglycerate mutase]
<Options>: A: pgam-m (homo sapiens) (aka phosphoglycerate mutase 2)
B: phosphoglycerate mutase 1 (homo sapiens) (aka phosphoglycerate mutase 1)
C: phosphoglycerate mutase 2 (mus musculus) (aka phosphoglycerate mutase 2)
D: phosphoglycerate mutase elevated 2 (mus musculus) (a... | [A] |
<Instruct>: Given the context 'Electrophoretic, heat lability, and mercury inhibition studies showed that the small residual activity in the patient's muscle was represented by the brain (BB) isoenzyme of phosphoglycerate mutase, suggesting a genetic defect of the M subunit which predominates in normal muscle.', select... | <Mentions>: [brain (bb) isoenzyme of phosphoglycerate mutase]
<Options>: A: phosphoglycerate mutase 2 (mus musculus) (aka phosphoglycerate mutase 2)
B: bisphosphoglycerate mutase (homo sapiens) (aka bisphosphoglycerate mutase)
C: pgam-b (homo sapiens) (phosphoglycerate mutase family member 4 (homo sapiens)) (aka phosph... | [D] |
<Instruct>: Given the context 'Linkage of the LW blood group locus with the complement C3 and Lutheran blood group loci.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lw blood group; complement c3; lutheran blood group]
<Options>: A: basal cell adhesion molecule (lutheran blood group) (xenopus tropicalis) (aka basal cell adhesion molecule (lutheran blood group))
B: opn1lw (bos taurus) (aka opsin 1, long wave sensitive)
C: complement c3 (rattus norvegicus) (aka complemen... | [F; O; L] |
<Instruct>: Given the context 'Linkage of the LW blood group locus with the complement C3 and Lutheran blood group loci.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lw blood group; complement c3; lutheran blood group]
<Options>: A: lulu (xenopus laevis) (erythrocyte membrane protein band 4.1 like 5 l homeolog (xenopus laevis)) (aka erythrocyte membrane protein band 4.1 like 5 l homeolog)
B: lu (bos taurus) (aka basal cell adhesion molecule)
C: complement c3 (rattus no... | [G; L; F] |
<Instruct>: Given the context 'Linkage of the LW blood group locus with the complement C3 and Lutheran blood group loci.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lw blood group; complement c3; lutheran blood group]
<Options>: A: immunoglobulin light chain, lambda gene cluster (bos taurus) (aka immunoglobulin light chain, lambda gene cluster)
B: basal cell adhesion molecule (lutheran blood group) (homo sapiens) (aka basal cell adhesion molecule (lutheran blood group... | [C; F; B] |
<Instruct>: Given the context 'Segregation data on LW in families of informative males show that the LW (Landsteiner-Wiener) blood group locus is closely linked to the complement C3 locus and to the locus for the Lutheran blood group.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [lw; lw (landsteiner-wiener) blood group; complement c3; lutheran blood group]
<Options>: A: wd repeat-containing protein lwd2-like (glycine max) (aka wd repeat-containing protein lwd2-like)
B: lulu (xenopus laevis) (erythrocyte membrane protein band 4.1 like 5 l homeolog (xenopus laevis)) (aka erythrocyte ... | [F; F; H; L] |
<Instruct>: Given the context 'Segregation data on LW in families of informative males show that the LW (Landsteiner-Wiener) blood group locus is closely linked to the complement C3 locus and to the locus for the Lutheran blood group.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [lw; lw (landsteiner-wiener) blood group; complement c3; lutheran blood group]
<Options>: A: lw-1 (homo sapiens) (aka heat shock transcription factor family, x-linked 1)
B: basal cell adhesion molecule (lutheran blood group) (rattus norvegicus) (aka basal cell adhesion molecule (lutheran blood group))
C: co... | [H; H; F; Q] |
<Instruct>: Given the context 'Segregation data on LW in families of informative males show that the LW (Landsteiner-Wiener) blood group locus is closely linked to the complement C3 locus and to the locus for the Lutheran blood group.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [lw; lw (landsteiner-wiener) blood group; complement c3; lutheran blood group]
<Options>: A: complement c3 (rattus norvegicus) (aka complement c3)
B: opn1lw (bos taurus) (aka opsin 1, long wave sensitive)
C: apo-c3 (homo sapiens) (aka apolipoprotein c3)
D: lulu (xenopus laevis) (erythrocyte membrane protein... | [R; R; Q; J] |
<Instruct>: Given the context 'Segregation data on LW in families of informative males show that the LW (Landsteiner-Wiener) blood group locus is closely linked to the complement C3 locus and to the locus for the Lutheran blood group.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [lw; lw (landsteiner-wiener) blood group; complement c3; lutheran blood group]
<Options>: A: gwl (bos taurus) (aka microtubule associated serine/threonine kinase like)
B: basal cell adhesion molecule (lutheran blood group) (rattus norvegicus) (aka basal cell adhesion molecule (lutheran blood group))
C: basa... | [Q; Q; G; C] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [apoe; le; c3; lw]
<Options>: A: lep (homo sapiens) (aka leptin)
B: apoe (bos taurus) (aka apolipoprotein e)
C: leb (homo sapiens) (aka mucin 5ac, oligomeric mucus/gel-forming)
D: c3 (gallus gallus) (aka complement component 3)
E: lwr (drosophila melanogaster) (aka lesswright)
F: apolipoprotein h (homo sapi... | [J; N; O; T] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [apoe; le; c3; lw]
<Options>: A: c3 (bos taurus) (aka complement c3)
B: apolipoprotein o (homo sapiens) (aka apolipoprotein o)
C: leb (homo sapiens) (aka mucin 5ac, oligomeric mucus/gel-forming)
D: complement component 3 precursor pseudogene (homo sapiens) (aka complement component 3 precursor pseudogene)
E... | [R; J; G; Q] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [apoe; le; c3; lw]
<Options>: A: c3g (drosophila melanogaster) (crossover suppressor on 3 of gowen (drosophila melanogaster)) (aka crossover suppressor on 3 of gowen)
B: apolipoprotein h (homo sapiens) (aka apolipoprotein h)
C: lep.l (xenopus laevis) (aka leptin l homeolog)
D: apolipoprotein o (homo sapiens... | [G; S; P; E] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [apoe; le; c3; lw]
<Options>: A: lep (homo sapiens) (aka leptin)
B: apolipoprotein h (homo sapiens) (aka apolipoprotein h)
C: apoe (oryctolagus cuniculus) (aka apolipoprotein e)
D: apo-e (homo sapiens) (aka apolipoprotein e)
E: lws (homo sapiens) (aka rna, u4atac small nuclear)
F: le (mus musculus) (aka hps... | [D; L; Q; H] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [lu; se; h; pepd]
<Options>: A: pepd (homo sapiens) (aka peptidase d)
B: sei1 (homo sapiens) (aka serta domain containing 1)
C: hhh (homo sapiens) (aka solute carrier family 25 member 15)
D: selenoh (gallus gallus) (aka selenoprotein h)
E: h (drosophila melanogaster) (hairless (drosophila melanogaster)) (ak... | [P; F; U; A] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [lu; se; h; pepd]
<Options>: A: pep.5 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 22)
B: pepd (homo sapiens) (aka peptidase d)
C: se (homo sapiens) (aka fucosyltransferase 2 (h blood group))
D: lulu (xenopus laevis) (erythrocyte membrane protein band 4.1 like 5 l homeolog (xenopus lae... | [I; C; U; B] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [lu; se; h; pepd]
<Options>: A: seh (homo sapiens) (aka epoxide hydrolase 2)
B: lulu1 (homo sapiens) (aka erythrocyte membrane protein band 4.1 like 5)
C: 28h (homo sapiens) (aka high mobility group nucleosomal binding domain 2 pseudogene 11)
D: lu1 (homo sapiens) (aka pdz domain containing 4)
E: pepe (homo... | [I; H; U; P] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [lu; se; h; pepd]
<Options>: A: selenon (homo sapiens) (aka selenoprotein n)
B: pepd (mus musculus) (aka peptidase d)
C: lulu (xenopus tropicalis) (aka erythrocyte membrane protein band 4.1 like 5)
D: selenoh (gallus gallus) (aka selenoprotein h)
E: se (homo sapiens) (aka fucosyltransferase 2 (h blood group... | [F; E; U; L] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [myotonic dystrophy; dm; neurofibromatosis; nf]
<Options>: A: fascin (rattus norvegicus) (aka fascin actin-bundling protein 1)
B: generalized neuroaxonal dystrophy (mus musculus) (aka generalized neuroaxonal dystrophy)
C: neurofascin (xenopus tropicalis) (aka neurofascin)
D: nf (rattus norvegicus) (aka neur... | [F; F; M; M] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [myotonic dystrophy; dm; neurofibromatosis; nf]
<Options>: A: dmilton (drosophila melanogaster) (aka milton)
B: myotonia (mus musculus) (aka chloride channel, voltage-sensitive 1)
C: neurofibromin 1 (rattus norvegicus) (aka neurofibromin 1)
D: neurofascin (xenopus tropicalis) (aka neurofascin)
E: neurofibro... | [O; O; Q; Q] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [myotonic dystrophy; dm; neurofibromatosis; nf]
<Options>: A: nf-m (mus musculus) (neurofilament, medium polypeptide (mus musculus)) (aka neurofilament, medium polypeptide)
B: nf (homo sapiens) (aka neurofascin)
C: dmd (mus musculus) (aka dystrophin, muscular dystrophy)
D: dmilton (drosophila melanogaster) ... | [P; P; J; J] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [myotonic dystrophy; dm; neurofibromatosis; nf]
<Options>: A: dm (homo sapiens) (aka dm1 protein kinase)
B: dystrophin, muscular dystrophy (mus musculus) (aka dystrophin, muscular dystrophy)
C: dm (mus musculus) (dystrophia myotonica-protein kinase (mus musculus)) (aka dystrophia myotonica-protein kinase)
D... | [A; A; K; K] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [familial hypercholesterolemia; fhc]
<Options>: A: fhf1 (homo sapiens) (aka fibroblast growth factor 12)
B: fh (gallus gallus) (aka fumarate hydratase)
C: fhf3 (homo sapiens) (aka fibroblast growth factor 11)
D: fhdc1 (homo sapiens) (aka fh2 domain containing 1)
E: hypoalphalipoproteinemia, primary (homo sa... | [I; I] |
<Instruct>: Given the context 'This finding also confirms the presence of a larger linkage group on chromosome 19, including now the loci for apoE, Le, C3, LW, Lu, Se, H, PEPD, myotonic dystrophy (DM), neurofibromatosis (NF) and familial hypercholesterolemia (FHC).', select the correct biomedical concept for each menti... | <Mentions>: [familial hypercholesterolemia; fhc]
<Options>: A: fhl1 (gallus gallus) (aka four and a half lim domains 1)
B: fh (homo sapiens) (complement factor h (homo sapiens)) (aka complement factor h)
C: fhc (homo sapiens) (low density lipoprotein receptor (homo sapiens)) (aka low density lipoprotein receptor)
D: fh... | [C; C] |
<Instruct>: Given the context 'Linkage of LW with the Lewis blood group locus could not be definitely established by the present family data, but small positive scores between LW and Le suggest that the Le locus is situated outside the C3-LW region.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [lw; lewis blood group; le]
<Options>: A: lep (homo sapiens) (aka leptin)
B: lectin, galactoside-binding-like l homeolog (xenopus laevis) (aka lectin, galactoside-binding-like l homeolog)
C: leo1 homolog, paf1/rna polymerase ii complex component l homeolog (xenopus laevis) (aka leo1 homolog, paf1/rna polyme... | [E; I; I] |
<Instruct>: Given the context 'Linkage of LW with the Lewis blood group locus could not be definitely established by the present family data, but small positive scores between LW and Le suggest that the Le locus is situated outside the C3-LW region.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [lw; lewis blood group; le]
<Options>: A: lwr (drosophila melanogaster) (aka lesswright)
B: lectin, galactoside-binding-like l homeolog (xenopus laevis) (aka lectin, galactoside-binding-like l homeolog)
C: selectin e (bos taurus) (aka selectin e)
D: lw (homo sapiens) (aka intercellular adhesion molecule 4 (... | [D; K; K] |
<Instruct>: Given the context 'Linkage of LW with the Lewis blood group locus could not be definitely established by the present family data, but small positive scores between LW and Le suggest that the Le locus is situated outside the C3-LW region.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [lw; lewis blood group; le]
<Options>: A: le (mus musculus) (aka hps4, biogenesis of lysosomal organelles complex 3 subunit 2)
B: leo1 homolog, paf1/rna polymerase ii complex component l homeolog (xenopus laevis) (aka leo1 homolog, paf1/rna polymerase ii complex component l homeolog)
C: opn1lw (homo sapiens... | [E; M; M] |
<Instruct>: Given the context 'Linkage of LW with the Lewis blood group locus could not be definitely established by the present family data, but small positive scores between LW and Le suggest that the Le locus is situated outside the C3-LW region.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [le; c3; lw]
<Options>: A: gwl (bos taurus) (aka microtubule associated serine/threonine kinase like)
B: complement component 3 precursor pseudogene (homo sapiens) (aka complement component 3 precursor pseudogene)
C: c3g (drosophila melanogaster) (crossover suppressor on 3 of gowen (drosophila melanogaster)... | [H; D; O] |
<Instruct>: Given the context 'Linkage of LW with the Lewis blood group locus could not be definitely established by the present family data, but small positive scores between LW and Le suggest that the Le locus is situated outside the C3-LW region.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [le; c3; lw]
<Options>: A: lwr (drosophila melanogaster) (aka lesswright)
B: les (homo sapiens) (aka fucosyltransferase 3 (lewis blood group))
C: lw (homo sapiens) (aka intercellular adhesion molecule 4 (landsteiner-wiener blood group))
D: apolipoprotein c3 (homo sapiens) (aka apolipoprotein c3)
E: lw (dros... | [B; H; C] |
<Instruct>: Given the context 'Linkage of LW with the Lewis blood group locus could not be definitely established by the present family data, but small positive scores between LW and Le suggest that the Le locus is situated outside the C3-LW region.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [le; c3; lw]
<Options>: A: complement component 3 (gallus gallus) (aka complement component 3)
B: apo-c3 (homo sapiens) (aka apolipoprotein c3)
C: lvwm (homo sapiens) (aka eukaryotic translation initiation factor 2b subunit epsilon)
D: lw (drosophila melanogaster) (aka long wing)
E: c3 (bos taurus) (aka com... | [K; G; M] |
<Instruct>: Given the context 'Human beta-nerve growth factor gene sequence highly homologous to that of mouse.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [beta-nerve growth factor]
<Options>: A: ngfb (rattus norvegicus) (aka nerve growth factor)
B: beta-ngf (xenopus tropicalis) (aka nerve growth factor)
C: nerve growth factor (homo sapiens) (aka nerve growth factor)
D: brain-derived neurotrophic factor (rattus norvegicus) (aka brain-derived neurotrophic fact... | [C] |
<Instruct>: Given the context 'Even so, beta-NGF comprises only approximately 0.1% of the protein in this small gland, which has made the study of this polypeptide difficult.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [beta-ngf]
<Options>: A: ngfb (bos taurus) (aka nerve growth factor)
B: beta-ngf (xenopus tropicalis) (aka nerve growth factor)
C: ngf (homo sapiens) (aka nerve growth factor)
D: ngfib (homo sapiens) (aka nuclear receptor subfamily 4 group a member 1)
E: brain-derived neurotrophic factor (rattus norvegicus)... | [C] |
<Instruct>: Given the context 'The amino acid sequence of the mouse NGF beta-chain has been determined and some information has been obtained regarding the size of a mouse precursor molecule, pro-beta-NGF, but little was known about the structure and relatedness of beta-NGF from other vertebrates.', select the correct ... | <Mentions>: [ngf beta; beta-ngf]
<Options>: A: beta-ngf (homo sapiens) (aka nerve growth factor)
B: neuromedin b (rattus norvegicus) (aka neuromedin b)
C: ngfb (bos taurus) (aka nerve growth factor)
D: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
E: neurotrophin 6 beta (pseudogene) (homo sapiens) (aka neurotr... | [I; A] |
<Instruct>: Given the context 'The amino acid sequence of the mouse NGF beta-chain has been determined and some information has been obtained regarding the size of a mouse precursor molecule, pro-beta-NGF, but little was known about the structure and relatedness of beta-NGF from other vertebrates.', select the correct ... | <Mentions>: [ngf beta; beta-ngf]
<Options>: A: lymphotoxin beta (homo sapiens) (aka lymphotoxin beta)
B: beta-ngf (xenopus tropicalis) (aka nerve growth factor)
C: beta-ngf (homo sapiens) (aka nerve growth factor)
D: neuropeptide b (rattus norvegicus) (aka neuropeptide b)
E: ngfb (bos taurus) (aka nerve growth factor)
... | [I; F] |
<Instruct>: Given the context 'Here we describe the isolation of mouse beta-NGF complementary DNA (cDNA) and present its nucleotide sequence, which predicts a prepro-beta-NGF molecule of Mr 27,000 (27K) and a pro-beta-NGF molecule of Mr 25K. We have used the mouse beta-NGF cDNA clone to isolate the human beta-NGF gene,... | <Mentions>: [beta-ngf]
<Options>: A: ngfb (rattus norvegicus) (aka nerve growth factor)
B: brain-derived neurotrophic factor (rattus norvegicus) (aka brain-derived neurotrophic factor)
C: beta-ngf (homo sapiens) (aka nerve growth factor)
D: ngfib (homo sapiens) (aka nuclear receptor subfamily 4 group a member 1)
E: bra... | [F] |
<Instruct>: Given the context 'Here we describe the isolation of mouse beta-NGF complementary DNA (cDNA) and present its nucleotide sequence, which predicts a prepro-beta-NGF molecule of Mr 27,000 (27K) and a pro-beta-NGF molecule of Mr 25K. We have used the mouse beta-NGF cDNA clone to isolate the human beta-NGF gene,... | <Mentions>: [beta-ngf]
<Options>: A: beta-ngf (rattus norvegicus) (aka nerve growth factor)
B: neurotrophin 6 beta (pseudogene) (homo sapiens) (aka neurotrophin 6 beta (pseudogene))
C: ngfb (bos taurus) (aka nerve growth factor)
D: ngfib (homo sapiens) (aka nuclear receptor subfamily 4 group a member 1)
E: beta-ngf (ho... | [E] |
<Instruct>: Given the context 'Mutations in the gene encoding the alpha subunit of the rod cGMP-gated channel in autosomal recessive retinitis pigmentosa.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semi... | <Mentions>: [alpha subunit of the rod cgmp-gated channel]
<Options>: A: cyclic nucleotide gated channel subunit alpha 1 (homo sapiens) (aka cyclic nucleotide gated channel subunit alpha 1)
B: cgmp-gated cation channel alpha-1-like (rattus norvegicus) (aka cgmp-gated cation channel alpha-1-like)
C: cholinergic receptor ... | [F] |
<Instruct>: Given the context 'Mutations in the genes encoding two proteins of the retinal rod phototransduction cascade, opsin and the beta subunit of rod cGMP phosphodiesterase, cause retinitis pigmentosa (RP) in some families.', select the correct biomedical concept for each mention using the provided options. Answe... | <Mentions>: [beta subunit of rod cgmp phosphodiesterase]
<Options>: A: pde3b (homo sapiens) (aka phosphodiesterase 3b)
B: phosphodiesterase 6b, cgmp, rod receptor, beta polypeptide (mus musculus) (aka phosphodiesterase 6b, cgmp, rod receptor, beta polypeptide)
C: pde6b (homo sapiens) (aka phosphodiesterase 6b)
D: pde8b... | [C] |
<Instruct>: Given the context 'We screened 94 unrelated patients with autosomal dominant RP and 173 unrelated patients with autosomal recessive RP for mutations in the gene encoding the alpha subunit of the rod cGMP-gated cation channel.', select the correct biomedical concept for each mention using the provided option... | <Mentions>: [alpha subunit of the rod cgmp-gated cation channel]
<Options>: A: achra (homo sapiens) (aka cholinergic receptor nicotinic alpha 1 subunit)
B: protein kinase camp-dependent type i regulatory subunit alpha (homo sapiens) (aka protein kinase camp-dependent type i regulatory subunit alpha)
C: cgmp-gated catio... | [F] |
<Instruct>: Given the context 'Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [cellular apoptosis susceptibility gene; cse1]
<Options>: A: csen (homo sapiens) (aka potassium voltage-gated channel interacting protein 3)
B: cuta divalent cation tolerance homolog (sus scrofa) (aka cuta divalent cation tolerance homolog)
C: cas (drosophila melanogaster) (chromosome segregation 1 (drosoph... | [F; H] |
<Instruct>: Given the context 'Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [cellular apoptosis susceptibility gene; cse1]
<Options>: A: cse1 (homo sapiens) (aka chromosome segregation 1 like)
B: ovarian cancer, epithelial, susceptibility to (homo sapiens) (aka ovarian cancer, epithelial, susceptibility to)
C: caspr (homo sapiens) (aka contactin associated protein 1)
D: cas (drosop... | [J; F] |
<Instruct>: Given the context 'Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [cellular apoptosis susceptibility gene; cse1]
<Options>: A: cancer susceptibility 11 (homo sapiens) (aka cancer susceptibility 11)
B: atherosclerosis susceptibility (lipoprotein associated) (homo sapiens) (aka atherosclerosis susceptibility (lipoprotein associated))
C: cas (drosophila melanogaster) (chromo... | [F; H] |
<Instruct>: Given the context 'We report here that one of these fragments is an antisense fragment of a gene homologous to the essential yeast chromosome segregation gene CSE1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each menti... | <Mentions>: [cse1]
<Options>: A: csec (homo sapiens) (aka sialic acid acetylesterase)
B: cse1l (homo sapiens) (aka chromosome segregation 1 like)
C: csen (homo sapiens) (aka potassium voltage-gated channel interacting protein 3)
D: cse1 (escherichia coli str. k-12 substr. mg1655) (aka type i-e crispr system cascade sub... | [E] |
<Instruct>: Given the context 'Cloning and analysis of the full-length cDNA of the human CSE1 homologue, which we name CAS for cellular apoptosis susceptibility gene, reveals a protein coding region with similar length (971 amino acids for CAS, 960 amino acids for CSE1) and 59% overall protein homology to the yeast CSE... | <Mentions>: [cse1; cas; cellular apoptosis susceptibility gene]
<Options>: A: casr (homo sapiens) (aka calcium sensing receptor)
B: cancer susceptibility 11 (homo sapiens) (aka cancer susceptibility 11)
C: cse1 chromosome segregation 1-like (xenopus tropicalis) (aka cse1 chromosome segregation 1-like)
D: bcar1 scaffold... | [H; G; G] |
<Instruct>: Given the context 'Cloning and analysis of the full-length cDNA of the human CSE1 homologue, which we name CAS for cellular apoptosis susceptibility gene, reveals a protein coding region with similar length (971 amino acids for CAS, 960 amino acids for CSE1) and 59% overall protein homology to the yeast CSE... | <Mentions>: [cse1; cas; cellular apoptosis susceptibility gene]
<Options>: A: cas (homo sapiens) (chromosome segregation 1 like (homo sapiens)) (aka chromosome segregation 1 like)
B: cuta divalent cation tolerance like (sus scrofa) (aka cuta divalent cation tolerance like)
C: cse (drosophila melanogaster) (chromosome s... | [G; A; A] |
<Instruct>: Given the context 'Cloning and analysis of the full-length cDNA of the human CSE1 homologue, which we name CAS for cellular apoptosis susceptibility gene, reveals a protein coding region with similar length (971 amino acids for CAS, 960 amino acids for CSE1) and 59% overall protein homology to the yeast CSE... | <Mentions>: [cse1; cas; cellular apoptosis susceptibility gene]
<Options>: A: radiation sensitivity/chromosome instability syndrome, autosomal dominant (homo sapiens) (aka radiation sensitivity/chromosome instability syndrome, autosomal dominant)
B: cas (homo sapiens) (chromosome segregation 1 like (homo sapiens)) (aka... | [E; B; B] |
<Instruct>: Given the context 'Cloning and analysis of the full-length cDNA of the human CSE1 homologue, which we name CAS for cellular apoptosis susceptibility gene, reveals a protein coding region with similar length (971 amino acids for CAS, 960 amino acids for CSE1) and 59% overall protein homology to the yeast CSE... | <Mentions>: [cse1]
<Options>: A: cse1 chromosome segregation 1-like s homeolog (xenopus laevis) (aka cse1 chromosome segregation 1-like s homeolog)
B: cse (drosophila melanogaster) (chromosome segregation 1 (drosophila melanogaster)) (aka chromosome segregation 1)
C: cse1 (saccharomyces cerevisiae s288c) (aka importin-... | [C] |
<Instruct>: Given the context 'The conservation of this gene indicates it has an important function in human cells consistent with the essential role of CSE1 in yeast.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separ... | <Mentions>: [cse1]
<Options>: A: cse1l (homo sapiens) (aka chromosome segregation 1 like)
B: cse1 chromosome segregation 1-like (xenopus tropicalis) (aka cse1 chromosome segregation 1-like)
C: cse1 (saccharomyces cerevisiae s288c) (aka importin-alpha export receptor)
D: csec (homo sapiens) (aka sialic acid acetylestera... | [C] |
<Instruct>: Given the context 'CAS is highly expressed in human tumor cell lines and in human testis and fetal liver, tissues that contain actively dividing cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [cas]
<Options>: A: cas (homo sapiens) (chromosome segregation 1 like (homo sapiens)) (aka chromosome segregation 1 like)
B: cas3 (homo sapiens) (aka embryonal fyn-associated substrate)
C: bcar1 scaffold protein, cas family member (gallus gallus) (aka bcar1 scaffold protein, cas family member)
D: casr (homo... | [A] |
<Instruct>: Given the context 'Furthermore, CAS expression increases when resting human fibroblasts are induced to proliferate and decreases when they are growth-arrested.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, s... | <Mentions>: [cas]
<Options>: A: cas (homo sapiens) (chromosome segregation 1 like (homo sapiens)) (aka chromosome segregation 1 like)
B: cas (homo sapiens) (bcar1 scaffold protein, cas family member (homo sapiens)) (aka bcar1 scaffold protein, cas family member)
C: cas1p (homo sapiens) (aka cas1 domain sialic acid o ac... | [A] |
<Instruct>: Given the context 'Thus, CAS appears to play an important role in both toxin and tumor necrosis factor-mediated cell death, as well as in cell proliferation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [cas]
<Options>: A: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas family member)
B: cas3 (homo sapiens) (aka embryonal fyn-associated substrate)
C: cas (drosophila melanogaster) (chromosome segregation 1 (drosophila melanogaster)) (aka chromosome segregation 1)
D:... | [D] |
<Instruct>: Given the context 'They were all located on the long arm of chromosome 17, in loci located between q11 and q21.3, a region known to contain the c-erbB-2 oncogene and the BRCA1 breast carcinomas, and overexpression of three of them was dependent on gene amplification in breast cancer cell lines.', select the... | <Mentions>: [c-erbb-2; brca1]
<Options>: A: c-erbb3 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 3)
B: erbb2 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
C: brca1 associated protein (homo sapiens) (aka brca1 associated protein)
D: brca1 (homo sapiens) (aka brca1 dna repair associated)
E: brisc and brca... | [B; D] |
<Instruct>: Given the context 'They were all located on the long arm of chromosome 17, in loci located between q11 and q21.3, a region known to contain the c-erbB-2 oncogene and the BRCA1 breast carcinomas, and overexpression of three of them was dependent on gene amplification in breast cancer cell lines.', select the... | <Mentions>: [c-erbb-2; brca1]
<Options>: A: brca1 associated protein (homo sapiens) (aka brca1 associated protein)
B: erbb3 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 3)
C: erbb2 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
D: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
E: brca1 (homo s... | [C; E] |
<Instruct>: Given the context 'Molecular cloning of the human homolog of a striatum-enriched phosphatase (STEP) gene and chromosomal mapping of the human and murine loci.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, s... | <Mentions>: [striatum-enriched phosphatase; step]
<Options>: A: ptpstep (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 5)
B: ptpe (homo sapiens) (aka protein tyrosine phosphatase receptor type e)
C: step (mus musculus) (aka protein tyrosine phosphatase, non-receptor type 5)
D: stp-1 (sus scrofa) (ak... | [A; A] |
<Instruct>: Given the context 'Molecular cloning of the human homolog of a striatum-enriched phosphatase (STEP) gene and chromosomal mapping of the human and murine loci.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, s... | <Mentions>: [striatum-enriched phosphatase; step]
<Options>: A: stepp (homo sapiens) (aka peroxisomal testis enriched protein 1)
B: ptpstep (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 5)
C: phosphoserine phosphatase (sus scrofa) (aka phosphoserine phosphatase)
D: phosphoserine phosphatase (homo s... | [B; B] |
<Instruct>: Given the context 'By using a combination of somatic cell hybrid analysis and fluorescence in situ hybridization, we have mapped the human STEP locus to chromosome 11p15.2-p15.1 and the murine STEP gene to chromosome 7B3-B5.', select the correct biomedical concept for each mention using the provided options... | <Mentions>: [step]
<Options>: A: tptep (homo sapiens) (aka tpte2 pseudogene 4)
B: step (mus musculus) (aka protein tyrosine phosphatase, non-receptor type 5)
C: step1 (arabidopsis thaliana) (aka 31-kda rna binding protein)
D: stp-1 (sus scrofa) (aka transition protein 1)
E: step61 (homo sapiens) (aka protein tyrosine p... | [E] |
<Instruct>: Given the context 'These are two regions of known conserved synteny, providing further evidence that the human STEP is a true homolog of the murine STEP gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, se... | <Mentions>: [step]
<Options>: A: step (mus musculus) (aka protein tyrosine phosphatase, non-receptor type 5)
B: step61 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 5)
C: step1 (arabidopsis thaliana) (aka 31-kda rna binding protein)
D: tppp (sus scrofa) (aka tubulin polymerization promoting protein... | [B] |
<Instruct>: Given the context 'Cloning of the cDNA for the human ATP synthase OSCP subunit (ATP5O) by exon trapping and mapping to chromosome 21q22.1-q22.2.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [atp synthase oscp subunit; atp5o]
<Options>: A: atp5l (homo sapiens) (aka atp synthase membrane subunit g)
B: atp synthase subunit o, mitochondrial (caenorhabditis elegans) (aka atp synthase subunit o, mitochondrial)
C: atp5o (mus musculus) (aka atp synthase peripheral stalk subunit oscp)
D: atp synthase p... | [I; I] |
<Instruct>: Given the context 'Cloning of the cDNA for the human ATP synthase OSCP subunit (ATP5O) by exon trapping and mapping to chromosome 21q22.1-q22.2.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [atp synthase oscp subunit; atp5o]
<Options>: A: oscp (homo sapiens) (atp synthase peripheral stalk subunit oscp (homo sapiens)) (aka atp synthase peripheral stalk subunit oscp)
B: atp5e (homo sapiens) (aka atp synthase f1 subunit epsilon)
C: atp synthase peripheral stalk subunit oscp (mus musculus) (aka at... | [A; A] |
<Instruct>: Given the context 'We subsequently cloned the full-length human ATP synthase OSCP cDNA (GDB/HGMW approved name ATP50) from infant brain and muscle libraries and determined its nucleotide and deduced amino acid sequence (EMBL/GenBank Accession No. X83218).', select the correct biomedical concept for each men... | <Mentions>: [atp synthase oscp; atp50]
<Options>: A: atpase (homo sapiens) (aka dynein axonemal heavy chain 8)
B: atpo (xenopus laevis) (atp synthase peripheral stalk subunit oscp s homeolog (xenopus laevis)) (aka atp synthase peripheral stalk subunit oscp s homeolog)
C: atp5o (oryctolagus cuniculus) (aka atp synthase ... | [I; I] |
<Instruct>: Given the context 'We subsequently cloned the full-length human ATP synthase OSCP cDNA (GDB/HGMW approved name ATP50) from infant brain and muscle libraries and determined its nucleotide and deduced amino acid sequence (EMBL/GenBank Accession No. X83218).', select the correct biomedical concept for each men... | <Mentions>: [atp synthase oscp; atp50]
<Options>: A: oscp (homo sapiens) (atp synthase peripheral stalk subunit oscp (homo sapiens)) (aka atp synthase peripheral stalk subunit oscp)
B: atp5 (homo sapiens) (aka atp synthase peripheral stalk subunit f6)
C: atp synthase peripheral stalk subunit oscp (mus musculus) (aka at... | [A; A] |
<Instruct>: Given the context 'The human ATP5O gene is located at 21q22.1-q22.2, just proximal to D21S17, in YACs 860G11 and 838C7 of the Chumakov et al.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [atp5o]
<Options>: A: atp5o (mus musculus) (aka atp synthase peripheral stalk subunit oscp)
B: atp5o (homo sapiens) (aka atp synthase peripheral stalk subunit oscp)
C: atp5l (homo sapiens) (aka atp synthase membrane subunit g)
D: atp5lp5 (homo sapiens) (aka atp synthase membrane subunit g pseudogene 5)
E: a... | [B] |
<Instruct>: Given the context 'This ATP5O subunit is a key structural component of the stalk of the mitochondrial respiratory chain F1F0-ATP synthase and as such may contribute in a gene dosage-dependent manner to the phenotype of Down syndrome (trisomy 21).', select the correct biomedical concept for each mention usin... | <Mentions>: [atp5o]
<Options>: A: atp5e (homo sapiens) (aka atp synthase f1 subunit epsilon)
B: atp5l (homo sapiens) (aka atp synthase membrane subunit g)
C: atp5h (homo sapiens) (aka atp synthase peripheral stalk subunit d)
D: atp5o (homo sapiens) (aka atp synthase peripheral stalk subunit oscp)
E: atp5o (mus musculus... | [D] |
<Instruct>: Given the context 'Genomic organization of the human gene (CA5) and pseudogene for mitochondrial carbonic anhydrase V and their localization to chromosomes 16q and 16p.
Carbonic anhydrase V (CA V) is expressed in mitochondrial matrix in liver and several other tissues.', select the correct biomedical concep... | <Mentions>: [ca5; mitochondrial carbonic anhydrase v; carbonic anhydrase v; ca v]
<Options>: A: coagulation factor v (homo sapiens) (aka coagulation factor v)
B: ca5 (gallus gallus) (aka carbonic anhydrase 5a)
C: putative carbonic anhydrase 5 (caenorhabditis elegans) (aka putative carbonic anhydrase 5)
D: carbonic anhy... | [G; G; G; G] |
<Instruct>: Given the context 'Genomic organization of the human gene (CA5) and pseudogene for mitochondrial carbonic anhydrase V and their localization to chromosomes 16q and 16p.
Carbonic anhydrase V (CA V) is expressed in mitochondrial matrix in liver and several other tissues.', select the correct biomedical concep... | <Mentions>: [ca5; mitochondrial carbonic anhydrase v; carbonic anhydrase v; ca v]
<Options>: A: carbonic anhydrase 5b (homo sapiens) (aka carbonic anhydrase 5b)
B: ca5p (homo sapiens) (aka carbonic anhydrase 5a pseudogene 1)
C: carbonic anhydrase vb, mitochondrial (xenopus tropicalis) (aka carbonic anhydrase vb, mitoch... | [G; G; G; G] |
<Instruct>: Given the context 'Genomic organization of the human gene (CA5) and pseudogene for mitochondrial carbonic anhydrase V and their localization to chromosomes 16q and 16p.
Carbonic anhydrase V (CA V) is expressed in mitochondrial matrix in liver and several other tissues.', select the correct biomedical concep... | <Mentions>: [ca5; mitochondrial carbonic anhydrase v; carbonic anhydrase v; ca v]
<Options>: A: ca5p (homo sapiens) (aka carbonic anhydrase 5a pseudogene 1)
B: ca5 (gallus gallus) (aka carbonic anhydrase 5a)
C: ca7.5 (mus musculus) (aka dna segment, ca7.5)
D: carbonic anhydrase vii s homeolog (xenopus laevis) (aka carb... | [F; F; F; F] |
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