instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
|---|---|---|
<Instruct>: Given the context 'Our findings suggest that FA1 is synthesized as a membrane anchored protein and released into the circulation after enzymic cleavage, and that circulating FA1 represents the post-translationally modified gene product of human dlk which, in turn, is identical to human adrenal-specific mRNA... | <Mentions>: [fa1; dlk; pg2]
<Options>: A: pg2 (mus musculus) (aka delta like non-canonical notch ligand 1)
B: dlg (drosophila melanogaster) (discs large 1 (drosophila melanogaster)) (aka discs large 1)
C: fa-1 (homo sapiens) (aka small nuclear ribonucleoprotein 13)
D: pgdp2 (homo sapiens) (aka phosphogluconate dehydrog... | [N; N; N] |
<Instruct>: Given the context 'Our findings suggest that FA1 is synthesized as a membrane anchored protein and released into the circulation after enzymic cleavage, and that circulating FA1 represents the post-translationally modified gene product of human dlk which, in turn, is identical to human adrenal-specific mRNA... | <Mentions>: [fa1; dlk; pg2]
<Options>: A: dlk/zpk (drosophila melanogaster) (aka wallenda)
B: ptgs2 (homo sapiens) (aka prostaglandin-endoperoxide synthase 2)
C: pgk2 (homo sapiens) (phosphoglycerate kinase 1, pseudogene 2 (homo sapiens)) (aka phosphoglycerate kinase 1, pseudogene 2)
D: dlk (drosophila melanogaster) (l... | [F; F; F] |
<Instruct>: Given the context 'Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dna helicase ii]
<Options>: A: dnah2 (homo sapiens) (aka dynein axonemal heavy chain 2)
B: dna helicase b (homo sapiens) (aka dna helicase b)
C: chromodomain helicase dna binding protein 2 (homo sapiens) (aka chromodomain helicase dna binding protein 2)
D: dbp2 (homo sapiens) (aka deah-box helicase 16)
E: ... | [F] |
<Instruct>: Given the context 'Human DNA helicase II (HDH II) is a novel ATP-dependent DNA unwinding enzyme, purified to apparent homogeneity from HeLa cells, which (i) unwinds exclusively DNA duplexes, (ii) prefers partially unwound substrates and (iii) proceeds in the 3' to 5' direction on the bound strand.', select ... | <Mentions>: [dna helicase ii; hdh ii]
<Options>: A: hyd2 (homo sapiens) (aka hypodontia 2 (autosomal recessive))
B: dna replication helicase/nuclease 2 (homo sapiens) (aka dna replication helicase/nuclease 2)
C: phd2 (homo sapiens) (aka egl-9 family hypoxia inducible factor 1)
D: dcoh2 (homo sapiens) (aka pterin-4 alph... | [K; K] |
<Instruct>: Given the context 'Human DNA helicase II (HDH II) is a novel ATP-dependent DNA unwinding enzyme, purified to apparent homogeneity from HeLa cells, which (i) unwinds exclusively DNA duplexes, (ii) prefers partially unwound substrates and (iii) proceeds in the 3' to 5' direction on the bound strand.', select ... | <Mentions>: [dna helicase ii; hdh ii]
<Options>: A: d2h (homo sapiens) (aka solute carrier family 3 member 1)
B: hyd2 (homo sapiens) (aka hypodontia 2 (autosomal recessive))
C: hdhd2 (homo sapiens) (aka haloacid dehalogenase like hydrolase domain containing 2)
D: dbp2 (homo sapiens) (aka deah-box helicase 16)
E: dnah2 ... | [J; J] |
<Instruct>: Given the context 'HDH II is a heterodimer of 72 and 87 kDa polypeptides.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hdh ii; heterodimer of 72 and 87 kda polypeptides]
<Options>: A: signal recognition particle 72kda (xenopus tropicalis) (aka signal recognition particle 72kda)
B: dcoh2 (homo sapiens) (aka pterin-4 alpha-carbinolamine dehydratase 2)
C: hst17287 (homo sapiens) (aka aquaporin 9)
D: hyd2 (homo sapiens) (aka h... | [K; K] |
<Instruct>: Given the context 'HDH II is a heterodimer of 72 and 87 kDa polypeptides.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hdh ii; heterodimer of 72 and 87 kda polypeptides]
<Options>: A: hdhd2 (homo sapiens) (aka haloacid dehalogenase like hydrolase domain containing 2)
B: signal recognition particle 72 (homo sapiens) (aka signal recognition particle 72)
C: dnah2 (homo sapiens) (aka dynein axonemal heavy chain 2)
D: p87/89 (h... | [K; K] |
<Instruct>: Given the context 'The antibodies raised in rabbit against either polypeptide can remove from the solution all the activities of HDH II.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hdh ii]
<Options>: A: dnah2 (homo sapiens) (aka dynein axonemal heavy chain 2)
B: dcoh2 (homo sapiens) (aka pterin-4 alpha-carbinolamine dehydratase 2)
C: hd2 (homo sapiens) (aka histone deacetylase 2)
D: phd2 (homo sapiens) (aka egl-9 family hypoxia inducible factor 1)
E: hdhd2b (homo sapiens) (aka phosph... | [F] |
<Instruct>: Given the context 'Microsequencing of the separate polypeptides of HDH II and cross-reaction with specific antibodies showed that this enzyme is identical to Ku, an autoantigen recognized by the sera of scleroderma and lupus erythematosus patients, which binds specifically to duplex DNA ends and is regulato... | <Mentions>: [hdh ii]
<Options>: A: cphd2 (homo sapiens) (aka prop paired-like homeobox 1)
B: hd2 (homo sapiens) (aka histone deacetylase 2)
C: dnah2 (homo sapiens) (aka dynein axonemal heavy chain 2)
D: dcoh2 (homo sapiens) (aka pterin-4 alpha-carbinolamine dehydratase 2)
E: hyd2 (homo sapiens) (aka hypodontia 2 (autos... | [F] |
<Instruct>: Given the context 'Recombinant HDH II/Ku protein expressed in and purified from Escherichia coli cells showed DNA binding and helicase activities indistinguishable from those of the isolated protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [hdh ii/ku]
<Options>: A: atp-dependent dna helicase ii subunit 2;ku c-terminal domain-containing protein;ku_pk_bind domain-containing protein (caenorhabditis elegans) (aka atp-dependent dna helicase ii subunit 2;ku c-terminal domain-containing protein;ku_pk_bind domain-containing protein)
B: kud (homo sapi... | [D] |
<Instruct>: Given the context 'The exclusively nuclear location of HDH II/Ku antigen, its highly specific affinity for double-stranded DNA, its abundance and its newly demonstrated ability to unwind exclusively DNA duplexes, point to an additional, if still unclear, role for this molecule in DNA metabolism.', select th... | <Mentions>: [hdh ii/ku]
<Options>: A: kub3 (homo sapiens) (aka atp23 metallopeptidase and atp synthase assembly factor homolog)
B: atp-dependent dna helicase 2 subunit ku70 (glycine max) (aka atp-dependent dna helicase 2 subunit ku70)
C: ku70 (homo sapiens) (aka x-ray repair cross complementing 6)
D: atp-dependent dna ... | [E] |
<Instruct>: Given the context 'A new cytokine (IK) down-regulating HLA class II: monoclonal antibodies, cloning and chromosome localization.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cytokine (ik)]
<Options>: A: ik cytokine (rattus norvegicus) (aka ik cytokine)
B: ik cytokine (xenopus tropicalis) (aka ik cytokine)
C: ik cytokine (oryctolagus cuniculus) (aka ik cytokine)
D: ik cytokine (sus scrofa) (aka ik cytokine)
E: ik cytokine (homo sapiens) (aka ik cytokine)
F: None of the above. | [E] |
<Instruct>: Given the context 'We have purified a cytokine (IK factor, 19 kDa) secreted by the leukemic cell line K562 and several cancer cells, which inhibits HLA Class II antigen induction by IFN-gamma.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [ik factor; ifn-gamma]
<Options>: A: ik1 (xenopus laevis) (ikaros family zinc finger 1 l homeolog (xenopus laevis)) (aka ikaros family zinc finger 1 l homeolog)
B: iklf (homo sapiens) (aka klf transcription factor 5)
C: ik (homo sapiens) (ik cytokine (homo sapiens)) (aka ik cytokine)
D: ik-1 (xenopus tropic... | [C; G] |
<Instruct>: Given the context 'We have purified a cytokine (IK factor, 19 kDa) secreted by the leukemic cell line K562 and several cancer cells, which inhibits HLA Class II antigen induction by IFN-gamma.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [ik factor; ifn-gamma]
<Options>: A: interferon gamma (homo sapiens) (aka interferon gamma)
B: ik-1 (xenopus tropicalis) (aka ikaros family zinc finger 1)
C: interleukin 36 gamma (homo sapiens) (aka interleukin 36 gamma)
D: iklf (homo sapiens) (aka klf transcription factor 5)
E: interferon gamma (xenopus tr... | [J; A] |
<Instruct>: Given the context 'We produced specific mAbs which antagonize the biological effect of IK in colon carcinoma Colo 205 cells induced to express HLA-DR molecules by IFN-gamma.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for e... | <Mentions>: [ik; ifn-gamma]
<Options>: A: ik (bos taurus) (aka ik cytokine)
B: ik (mus musculus) (aka ik cytokine)
C: ifn-gamma (gallus gallus) (aka interferon)
D: interferon gamma (homo sapiens) (aka interferon gamma)
E: interferon gamma (mus musculus) (aka interferon gamma)
F: ikk-i (homo sapiens) (aka inhibitor of n... | [I; D] |
<Instruct>: Given the context 'We produced specific mAbs which antagonize the biological effect of IK in colon carcinoma Colo 205 cells induced to express HLA-DR molecules by IFN-gamma.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for e... | <Mentions>: [ik; ifn-gamma]
<Options>: A: ik (mus musculus) (aka ik cytokine)
B: interleukin 36 gamma (homo sapiens) (aka interleukin 36 gamma)
C: gmf-gamma (homo sapiens) (aka glia maturation factor gamma)
D: interferon gamma (mus musculus) (aka interferon gamma)
E: ik (bos taurus) (aka ik cytokine)
F: ik (drosophila ... | [I; J] |
<Instruct>: Given the context 'Moreover, in Colo 205, HLA-DR can also be induced by the protein synthesis inhibitor Cycloheximide (0.1 micrograms ml-1); and addition of IK factor almost completely abolishes HLA class II expression.', select the correct biomedical concept for each mention using the provided options. Ans... | <Mentions>: [ik factor]
<Options>: A: ik (homo sapiens) (ik cytokine (homo sapiens)) (aka ik cytokine)
B: iklf (mus musculus) (aka kruppel-like transcription factor 5)
C: iklf (homo sapiens) (aka klf transcription factor 5)
D: ik-1 (xenopus tropicalis) (aka ikaros family zinc finger 1)
E: ikzf1 (homo sapiens) (aka ikar... | [A] |
<Instruct>: Given the context 'IK gene localization shows that it maps on chromosome 2p15-p14.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ik]
<Options>: A: ik cytokine (homo sapiens) (aka ik cytokine)
B: ik (bos taurus) (aka ik cytokine)
C: ik (mus musculus) (aka ik cytokine)
D: ik (drosophila melanogaster) (aka i-kappab kinase beta)
E: ik1 (mus musculus) (aka potassium intermediate/small conductance calcium-activated channel, subfamily n, m... | [A] |
<Instruct>: Given the context 'BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bmx; btk; itk; tec]
<Options>: A: bruton tyrosine kinase (homo sapiens) (aka bruton tyrosine kinase)
B: bmx (mus musculus) (aka bmx non-receptor tyrosine kinase)
C: tec (xenopus laevis) (tec protein tyrosine kinase l homeolog (xenopus laevis)) (aka tec protein tyrosine kinase l homeolog)
D: tec protein tyr... | [K; A; L; M] |
<Instruct>: Given the context 'BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bmx; btk; itk; tec]
<Options>: A: btkl (homo sapiens) (aka txk tyrosine kinase)
B: teck (xenopus tropicalis) (aka c-c motif chemokine ligand 25)
C: itk (bos taurus) (aka il2 inducible t cell kinase)
D: itk (gallus gallus) (aka il2 inducible t-cell kinase)
E: bmnx (mus musculus) (aka body mass index)
F: il2... | [N; O; F; M] |
<Instruct>: Given the context 'BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bmx; btk; itk; tec]
<Options>: A: bruton tyrosine kinase (xenopus tropicalis) (aka bruton tyrosine kinase)
B: tec (sus scrofa) (aka tec protein tyrosine kinase)
C: tec (xenopus laevis) (tec protein tyrosine kinase l homeolog (xenopus laevis)) (aka tec protein tyrosine kinase l homeolog)
D: teck (xenopus tr... | [M; K; G; L] |
<Instruct>: Given the context 'BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bmx; btk; itk; tec]
<Options>: A: btkl (homo sapiens) (aka txk tyrosine kinase)
B: ick (homo sapiens) (aka ciliogenesis associated kinase 1)
C: bmnx (mus musculus) (aka body mass index)
D: il2 inducible t cell kinase (homo sapiens) (aka il2 inducible t cell kinase)
E: bmx (bos taurus) (aka bmx non-receptor... | [L; K; D; T] |
<Instruct>: Given the context 'BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [txk]
<Options>: A: txk tyrosine kinase (sus scrofa) (aka txk tyrosine kinase)
B: txk (bos taurus) (aka txk tyrosine kinase)
C: txk (gallus gallus) (aka txk tyrosine kinase)
D: txk (danio rerio) (aka txk tyrosine kinase)
E: txk (homo sapiens) (aka txk tyrosine kinase)
F: None of the above. | [E] |
<Instruct>: Given the context 'The Bmx sequence was identified and cloned during our search for novel tyrosine kinase genes expressed in human bone marrow cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [bmx]
<Options>: A: bmnx (mus musculus) (aka body mass index)
B: mbx (homo sapiens) (aka diencephalon/mesencephalon homeobox 1)
C: bmx (mus musculus) (aka bmx non-receptor tyrosine kinase)
D: bmx non-receptor tyrosine kinase (homo sapiens) (aka bmx non-receptor tyrosine kinase)
E: bmx (bos taurus) (aka bmx ... | [D] |
<Instruct>: Given the context 'Bmx cDNA comprises a long open reading frame of 675 amino acids, containing one SH3, one SH2 and one tyrosine kinase domain, which are about 70% identical with Btk, Itk and Tec and somewhat less with Txk tyrosine kinase sequences.', select the correct biomedical concept for each mention u... | <Mentions>: [bmx; btk; itk; tec]
<Options>: A: ibtk (homo sapiens) (aka inhibitor of bruton tyrosine kinase)
B: tec (homo sapiens) (tec protein tyrosine kinase (homo sapiens)) (aka tec protein tyrosine kinase)
C: tec (sus scrofa) (aka tec protein tyrosine kinase)
D: blk proto-oncogene, src family tyrosine kinase (homo ... | [S; J; R; B] |
<Instruct>: Given the context 'Bmx cDNA comprises a long open reading frame of 675 amino acids, containing one SH3, one SH2 and one tyrosine kinase domain, which are about 70% identical with Btk, Itk and Tec and somewhat less with Txk tyrosine kinase sequences.', select the correct biomedical concept for each mention u... | <Mentions>: [bmx; btk; itk; tec]
<Options>: A: itk (mus musculus) (aka il2 inducible t cell kinase)
B: btk (homo sapiens) (aka bruton tyrosine kinase)
C: tec (sus scrofa) (aka tec protein tyrosine kinase)
D: bruton tyrosine kinase (bos taurus) (aka bruton tyrosine kinase)
E: blk proto-oncogene, src family tyrosine kina... | [K; B; F; O] |
<Instruct>: Given the context 'Bmx cDNA comprises a long open reading frame of 675 amino acids, containing one SH3, one SH2 and one tyrosine kinase domain, which are about 70% identical with Btk, Itk and Tec and somewhat less with Txk tyrosine kinase sequences.', select the correct biomedical concept for each mention u... | <Mentions>: [bmx; btk; itk; tec]
<Options>: A: btkl (homo sapiens) (aka txk tyrosine kinase)
B: tec (homo sapiens) (transient erythroblastopenia of childhood (homo sapiens)) (aka transient erythroblastopenia of childhood)
C: bmnx (mus musculus) (aka body mass index)
D: bmx (bos taurus) (aka bmx non-receptor tyrosine ki... | [G; N; I; O] |
<Instruct>: Given the context 'Bmx cDNA comprises a long open reading frame of 675 amino acids, containing one SH3, one SH2 and one tyrosine kinase domain, which are about 70% identical with Btk, Itk and Tec and somewhat less with Txk tyrosine kinase sequences.', select the correct biomedical concept for each mention u... | <Mentions>: [bmx; btk; itk; tec]
<Options>: A: itk (gallus gallus) (aka il2 inducible t-cell kinase)
B: teck (xenopus tropicalis) (aka c-c motif chemokine ligand 25)
C: blk proto-oncogene, src family tyrosine kinase (bos taurus) (aka blk proto-oncogene, src family tyrosine kinase)
D: bmx non-receptor tyrosine kinase (m... | [H; F; N; G] |
<Instruct>: Given the context 'Bmx cDNA comprises a long open reading frame of 675 amino acids, containing one SH3, one SH2 and one tyrosine kinase domain, which are about 70% identical with Btk, Itk and Tec and somewhat less with Txk tyrosine kinase sequences.', select the correct biomedical concept for each mention u... | <Mentions>: [txk]
<Options>: A: txk tyrosine kinase (sus scrofa) (aka txk tyrosine kinase)
B: txk (gallus gallus) (aka txk tyrosine kinase)
C: txk (bos taurus) (aka txk tyrosine kinase)
D: txk (homo sapiens) (aka txk tyrosine kinase)
E: txk (danio rerio) (aka txk tyrosine kinase)
F: None of the above. | [D] |
<Instruct>: Given the context 'The 2.7 kb Bmx mRNA was expressed in endothelial cells and several human tissues by Northern blotting and an 80 kD Bmx polypeptide was detected in human endothelial cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected o... | <Mentions>: [bmx]
<Options>: A: bmx (homo sapiens) (aka bmx non-receptor tyrosine kinase)
B: bmx non-receptor tyrosine kinase (mus musculus) (aka bmx non-receptor tyrosine kinase)
C: mbx (homo sapiens) (aka diencephalon/mesencephalon homeobox 1)
D: bmx (rattus norvegicus) (aka bmx non-receptor tyrosine kinase)
E: bmh (... | [A] |
<Instruct>: Given the context 'Immunoprecipitates of COS cells transfected with a Bmx expression vector and NIH3T3 cells expressing a Bmx retrovirus contained a tyrosyl phosphorylated Bmx polypeptide of similar molecular weight.', select the correct biomedical concept for each mention using the provided options. Answer... | <Mentions>: [bmx]
<Options>: A: bmx (mus musculus) (aka bmx non-receptor tyrosine kinase)
B: bmh (xenopus tropicalis) (aka bleomycin hydrolase)
C: bmx (rattus norvegicus) (aka bmx non-receptor tyrosine kinase)
D: bmx (bos taurus) (aka bmx non-receptor tyrosine kinase)
E: bmx non-receptor tyrosine kinase (homo sapiens) ... | [E] |
<Instruct>: Given the context 'The BMX gene was located in chromosomal band Xp22.2 between the DXS197 and DXS207 loci.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bmx]
<Options>: A: bmx (gallus gallus) (aka bmx non-receptor tyrosine kinase)
B: bmx (homo sapiens) (aka bmx non-receptor tyrosine kinase)
C: mbx (homo sapiens) (aka diencephalon/mesencephalon homeobox 1)
D: bmx (bos taurus) (aka bmx non-receptor tyrosine kinase)
E: bmx (rattus norvegicus) (aka bmx non-rec... | [B] |
<Instruct>: Given the context 'Interestingly, chromosome X also contains the closest relative of BMX, the BTK gene, implicated in X-linked agammaglobulinemia.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [bmx; btk]
<Options>: A: bmx (gallus gallus) (aka bmx non-receptor tyrosine kinase)
B: bruton tyrosine kinase (xenopus tropicalis) (aka bruton tyrosine kinase)
C: btk (bos taurus) (aka bruton tyrosine kinase)
D: btkl (homo sapiens) (aka txk tyrosine kinase)
E: blk (homo sapiens) (aka blk proto-oncogene, src... | [F; J] |
<Instruct>: Given the context 'Interestingly, chromosome X also contains the closest relative of BMX, the BTK gene, implicated in X-linked agammaglobulinemia.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [bmx; btk]
<Options>: A: btk (bos taurus) (aka bruton tyrosine kinase)
B: mbx (homo sapiens) (aka diencephalon/mesencephalon homeobox 1)
C: blk proto-oncogene, src family tyrosine kinase (xenopus tropicalis) (aka blk proto-oncogene, src family tyrosine kinase)
D: bmx (bos taurus) (aka bmx non-receptor tyros... | [F; J] |
<Instruct>: Given the context 'The BMX gene thus encodes a novel nonreceptor tyrosine kinase, which may play a role in the growth and differentiation of hematopoietic cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [bmx]
<Options>: A: bmx (rattus norvegicus) (aka bmx non-receptor tyrosine kinase)
B: bmh (xenopus tropicalis) (aka bleomycin hydrolase)
C: bmx (homo sapiens) (aka bmx non-receptor tyrosine kinase)
D: bmnx (mus musculus) (aka body mass index)
E: mbx (homo sapiens) (aka diencephalon/mesencephalon homeobox 1)... | [C] |
<Instruct>: Given the context 'The BMX gene thus encodes a novel nonreceptor tyrosine kinase, which may play a role in the growth and differentiation of hematopoietic cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [bmx]
<Options>: A: bmh (xenopus tropicalis) (aka bleomycin hydrolase)
B: bmnx (mus musculus) (aka body mass index)
C: mbx (homo sapiens) (aka diencephalon/mesencephalon homeobox 1)
D: bmx (rattus norvegicus) (aka bmx non-receptor tyrosine kinase)
E: None of the above. | [E] |
<Instruct>: Given the context 'Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [brk]
<Options>: A: brk (homo sapiens) (aka protein tyrosine kinase 6)
B: brks (homo sapiens) (aka fkbp prolyl isomerase 10)
C: br serine/threonine kinase 1 (homo sapiens) (aka br serine/threonine kinase 1)
D: brk1 (homo sapiens) (aka brick1 subunit of scar/wave actin nucleating complex)
E: brk (mus musculu... | [A] |
<Instruct>: Given the context 'Using a polymerase chain reaction based differential screening approach, we have isolated and characterised a cDNA from a human metastatic breast tumour representing a novel protein tyrosine kinase (brk).', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [brk]
<Options>: A: brk1 (bos taurus) (aka brick1 subunit of scar/wave actin nucleating complex)
B: brpk (homo sapiens) (aka pten induced kinase 1)
C: brk1 (homo sapiens) (aka brick1 subunit of scar/wave actin nucleating complex)
D: brk (homo sapiens) (aka protein tyrosine kinase 6)
E: brk (mus musculus) (a... | [D] |
<Instruct>: Given the context 'Sequencing of brk cDNAs isolated from T-47D and MCF-7 human breast tumour cell lines indicate that they encode a protein with the features of a novel nonreceptor tyrosine kinase, including amino terminal SH3 and SH2 domains.', select the correct biomedical concept for each mention using t... | <Mentions>: [brk]
<Options>: A: brk (homo sapiens) (aka protein tyrosine kinase 6)
B: brpk (homo sapiens) (aka pten induced kinase 1)
C: brk1 (bos taurus) (aka brick1 subunit of scar/wave actin nucleating complex)
D: brk (drosophila melanogaster) (aka brinker)
E: brk (mus musculus) (aka ptk6 protein tyrosine kinase 6)
... | [A] |
<Instruct>: Given the context 'When synthesised in recombinant baculovirus and bacterial expression systems, brk protein products are capable of autophosphorylation on tyrosine residues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ... | <Mentions>: [brk]
<Options>: A: brk1 (bos taurus) (aka brick1 subunit of scar/wave actin nucleating complex)
B: brk (homo sapiens) (aka protein tyrosine kinase 6)
C: brk-1 (gallus gallus) (aka bone morphogenetic protein receptor type 1a)
D: brk1 (homo sapiens) (aka brick1 subunit of scar/wave actin nucleating complex)
... | [B] |
<Instruct>: Given the context 'Initial expression studies have detected low levels of brk transcripts in some human breast tumours and breast tumour cell lines, but not in normal breast tissue.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [brk]
<Options>: A: brk1 (homo sapiens) (aka brick1 subunit of scar/wave actin nucleating complex)
B: brpk (homo sapiens) (aka pten induced kinase 1)
C: brk (homo sapiens) (aka protein tyrosine kinase 6)
D: brk (drosophila melanogaster) (aka brinker)
E: brk-1 (gallus gallus) (aka bone morphogenetic protein ... | [C] |
<Instruct>: Given the context 'Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [pc4]
<Options>: A: pc4 (mus musculus) (sub1 homolog, transcriptional regulator (mus musculus)) (aka sub1 homolog, transcriptional regulator)
B: pch4 (homo sapiens) (aka trna splicing endonuclease subunit 54)
C: pc4 (xenopus laevis) (aka proprotein convertase subtilisin/kexin type 4 l homeolog)
D: pc4 (mus ... | [E] |
<Instruct>: Given the context 'A novel positive cofactor (PC4) purified from the human USA fraction effected a marked enhancement (up to 85-fold) of GAL4-AH-dependent transcription in conjunction with TFIID and other general factors.', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [pc4; gal4]
<Options>: A: prostate cancer, hereditary, 4 (homo sapiens) (aka prostate cancer, hereditary, 4)
B: pc4 (homo sapiens) (sub1 regulator of transcription (homo sapiens)) (aka sub1 regulator of transcription)
C: pc4 (mus musculus) (proprotein convertase subtilisin/kexin type 4 (mus musculus)) (aka ... | [B; H] |
<Instruct>: Given the context 'A novel positive cofactor (PC4) purified from the human USA fraction effected a marked enhancement (up to 85-fold) of GAL4-AH-dependent transcription in conjunction with TFIID and other general factors.', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [pc4; gal4]
<Options>: A: pch4 (homo sapiens) (aka trna splicing endonuclease subunit 54)
B: gtf-1 (drosophila melanogaster) (aka germ line transcription factor 1)
C: gal4 (saccharomyces cerevisiae s288c) (aka galactose-responsive transcription factor gal4)
D: gal4 (homo sapiens) (aka galectin 4)
E: pc4 (ho... | [E; D] |
<Instruct>: Given the context 'A novel positive cofactor (PC4) purified from the human USA fraction effected a marked enhancement (up to 85-fold) of GAL4-AH-dependent transcription in conjunction with TFIID and other general factors.', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [pc4; gal4]
<Options>: A: pc4 (mus musculus) (proprotein convertase subtilisin/kexin type 4 (mus musculus)) (aka proprotein convertase subtilisin/kexin type 4)
B: transcription activator glk1-like (glycine max) (aka transcription activator glk1-like)
C: pc4 (xenopus laevis) (aka proprotein convertase subtil... | [I; J] |
<Instruct>: Given the context 'Isolation of a corresponding cDNA identified PC4 as a 127 residue single-stranded DNA-binding protein with serine-rich regions near the N-terminus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [pc4]
<Options>: A: pc4 (mus musculus) (sub1 homolog, transcriptional regulator (mus musculus)) (aka sub1 homolog, transcriptional regulator)
B: pc4 (xenopus laevis) (aka proprotein convertase subtilisin/kexin type 4 l homeolog)
C: pc4 (homo sapiens) (sub1 regulator of transcription (homo sapiens)) (aka sub... | [C] |
<Instruct>: Given the context 'Recombinant PC4 was functionally equivalent to native PC4, and both proteins markedly enhanced activation by diverse activation domains fused to the DNA-binding domain of GAL4.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [pc4; gal4]
<Options>: A: gal4 (xenopus tropicalis) (aka lectin, galactoside-binding, soluble, 4, gene 2)
B: prostate cancer, hereditary, 4 (homo sapiens) (aka prostate cancer, hereditary, 4)
C: pc4-like (drosophila melanogaster) (aka single stranded-binding protein c31a)
D: pc4 (mus musculus) (proprotein c... | [G; I] |
<Instruct>: Given the context 'Recombinant PC4 was functionally equivalent to native PC4, and both proteins markedly enhanced activation by diverse activation domains fused to the DNA-binding domain of GAL4.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [pc4; gal4]
<Options>: A: gal4 (candida albicans sc5314) (aka galactose-responsive transcription factor)
B: gal4 (homo sapiens) (aka galectin 4)
C: pc4 (homo sapiens) (sub1 regulator of transcription (homo sapiens)) (aka sub1 regulator of transcription)
D: pc4 (xenopus laevis) (aka proprotein convertase sub... | [C; B] |
<Instruct>: Given the context 'Recombinant PC4 interacted independently both with free or DNA-bound VP16 activation domains and with free or DNA-bound TFIIA-TBP complexes (but not with TBP alone).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options... | <Mentions>: [pc4; tbp]
<Options>: A: tbp-b (xenopus tropicalis) (aka tata-box binding protein)
B: tata-box binding protein like 1 (xenopus tropicalis) (aka tata-box binding protein like 1)
C: pc4 (xenopus laevis) (aka proprotein convertase subtilisin/kexin type 4 l homeolog)
D: tbp (bos taurus) (aka tata-box binding pr... | [E; K] |
<Instruct>: Given the context 'Recombinant PC4 interacted independently both with free or DNA-bound VP16 activation domains and with free or DNA-bound TFIIA-TBP complexes (but not with TBP alone).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options... | <Mentions>: [pc4; tbp]
<Options>: A: tbp protein-like pseudogene (bos taurus) (aka tbp protein-like pseudogene)
B: tbp (bos taurus) (aka tata-box binding protein)
C: pch4 (homo sapiens) (aka trna splicing endonuclease subunit 54)
D: prostate cancer, hereditary, 4 (homo sapiens) (aka prostate cancer, hereditary, 4)
E: t... | [H; K] |
<Instruct>: Given the context 'These results indicate that PC4 is a general coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [pc4]
<Options>: A: prostate cancer, hereditary, 4 (homo sapiens) (aka prostate cancer, hereditary, 4)
B: pc4 (mus musculus) (proprotein convertase subtilisin/kexin type 4 (mus musculus)) (aka proprotein convertase subtilisin/kexin type 4)
C: pc4 (homo sapiens) (sub1 regulator of transcription (homo sapiens... | [C] |
<Instruct>: Given the context 'These results indicate that PC4 is a general coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [pc4]
<Options>: A: pc4-like (drosophila melanogaster) (aka single stranded-binding protein c31a)
B: pc4 (xenopus laevis) (aka proprotein convertase subtilisin/kexin type 4 l homeolog)
C: pc4 (mus musculus) (proprotein convertase subtilisin/kexin type 4 (mus musculus)) (aka proprotein convertase subtilisin/... | [E] |
<Instruct>: Given the context 'Molecular cloning, sequencing, and functional expression of a cDNA encoding human coproporphyrinogen oxidase.
Coproporphyrinogen oxidase (EC 1.3.3.3) catalyzes the sixth step in the heme biosynthetic pathway, the oxidation of coproporphyrinogen III to protoporphyrinogen IX.', select the c... | <Mentions>: [coproporphyrinogen oxidase]
<Options>: A: coproporphyrinogen oxidase (danio rerio) (aka coproporphyrinogen oxidase)
B: cpx (homo sapiens) (coproporphyrinogen oxidase (homo sapiens)) (aka coproporphyrinogen oxidase)
C: coproporphyrinogen oxidase (drosophila melanogaster) (aka coproporphyrinogen oxidase)
D: ... | [B] |
<Instruct>: Given the context 'The sequence of the cDNA and predicted amino acid sequence of the human coproporphyrinogen oxidase are presented.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [coproporphyrinogen oxidase]
<Options>: A: protoporphyrinogen oxidase (homo sapiens) (aka protoporphyrinogen oxidase)
B: coproporphyrinogen oxidase (drosophila melanogaster) (aka coproporphyrinogen oxidase)
C: coproporphyrinogen-iii oxidase-like (glycine max) (aka coproporphyrinogen-iii oxidase-like)
D: cop... | [E] |
<Instruct>: Given the context 'The human protein sequence contains a region completely homologous to that we obtained by sequencing an 11-amino acid peptide fragment from purified murine liver coproporphyrinogen oxidase.', select the correct biomedical concept for each mention using the provided options. Answer by list... | <Mentions>: [coproporphyrinogen oxidase]
<Options>: A: protoporphyrinogen oxidase (homo sapiens) (aka protoporphyrinogen oxidase)
B: coproporphyrinogen-iii oxidase-like (glycine max) (aka coproporphyrinogen-iii oxidase-like)
C: cox (homo sapiens) (coproporphyrinogen oxidase (homo sapiens)) (aka coproporphyrinogen oxida... | [C] |
<Instruct>: Given the context 'Results of Southern blotting were consistent with the presence of a single human coproporphyrinogen oxidase gene, and Northern blotting demonstrated one transcript of similar size in erythroid and nonerythroid cell lines.', select the correct biomedical concept for each mention using the ... | <Mentions>: [coproporphyrinogen oxidase]
<Options>: A: coproporphyrinogen oxidase (homo sapiens) (aka coproporphyrinogen oxidase)
B: coproporphyrinogen oxidase (danio rerio) (aka coproporphyrinogen oxidase)
C: coproporphyrinogen oxidase (glycine max) (aka coproporphyrinogen oxidase)
D: coproporphyrinogen oxidase (sacch... | [A] |
<Instruct>: Given the context 'Expression of the cDNA coding for the putative mature human coproporphyrinogen oxidase in Escherichia coli resulted in a 17-fold increase in coproporphyrinogen activity over endogenous activity.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [coproporphyrinogen oxidase]
<Options>: A: cox (homo sapiens) (coproporphyrinogen oxidase (homo sapiens)) (aka coproporphyrinogen oxidase)
B: coproporphyrinogen oxidase (drosophila melanogaster) (aka coproporphyrinogen oxidase)
C: coproporphyrinogen oxidase (saccharomyces cerevisiae s288c) (aka coproporphyr... | [A] |
<Instruct>: Given the context 'Molecular cloning and characterization of a novel human sperm antigen (HE2) specifically expressed in the proximal epididymis.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [he2]
<Options>: A: hebi2 (homo sapiens) (aka g protein-coupled receptor 183)
B: he2c (homo sapiens) (aka sperm associated antigen 11b)
C: he3b (homo sapiens) (aka epididymal protein 3b)
D: heag2 (homo sapiens) (aka potassium voltage-gated channel subfamily h member 5)
E: hey2 (homo sapiens) (aka hes relate... | [B] |
<Instruct>: Given the context 'A novel human cDNA encoding a small secretory glycopeptide specifically expressed within the caput and proximal corpus regions of the human epididymis, HE2, has been cloned and sequenced.', select the correct biomedical concept for each mention using the provided options. Answer by listin... | <Mentions>: [he2]
<Options>: A: heag2 (homo sapiens) (aka potassium voltage-gated channel subfamily h member 5)
B: he2c (homo sapiens) (aka sperm associated antigen 11b)
C: he1 (homo sapiens) (aka npc intracellular cholesterol transporter 2)
D: hey2 (homo sapiens) (aka hes related family bhlh transcription factor with ... | [B] |
<Instruct>: Given the context 'This recombinant HE2 protein, as well as an oligopeptide deduced from the open-reading frame, was used to raise polyclonal antisera.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [he2]
<Options>: A: heg (homo sapiens) (aka heart development protein with egf like domains 1)
B: heag2 (homo sapiens) (aka potassium voltage-gated channel subfamily h member 5)
C: hey2 (homo sapiens) (aka hes related family bhlh transcription factor with yrpw motif 2)
D: he3b (homo sapiens) (aka epididymal... | [E] |
<Instruct>: Given the context 'Immunohistochemistry and immunofluorescence showed that the predicted HE2 peptide is present in the epididymal epithelium and on the sperm surface, where it adopts a typical antigenic pattern with a subacrosomal equatorial distribution on the sperm head.', select the correct biomedical co... | <Mentions>: [he2]
<Options>: A: hey2 (homo sapiens) (aka hes related family bhlh transcription factor with yrpw motif 2)
B: heag2 (homo sapiens) (aka potassium voltage-gated channel subfamily h member 5)
C: he3b (homo sapiens) (aka epididymal protein 3b)
D: he1 (homo sapiens) (aka npc intracellular cholesterol transpor... | [E] |
<Instruct>: Given the context 'Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization.
Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotinamide and other pyridines.', select the correct biomedical concept for each mention using the provided op... | <Mentions>: [nicotinamide n-methyltransferase; nnmt]
<Options>: A: nnmt (xenopus tropicalis) (provisional ortholog of nicotinamide n-methyltransferase (xenopus tropicalis)) (aka provisional ortholog of nicotinamide n-methyltransferase)
B: nrmt (homo sapiens) (aka n-terminal xaa-pro-lys n-methyltransferase 1)
C: nicotin... | [E; E] |
<Instruct>: Given the context 'Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization.
Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotinamide and other pyridines.', select the correct biomedical concept for each mention using the provided op... | <Mentions>: [nicotinamide n-methyltransferase; nnmt]
<Options>: A: nicotinamide n-methyltransferase (mus musculus) (aka nicotinamide n-methyltransferase)
B: nnt (mus musculus) (aka nicotinamide nucleotide transhydrogenase)
C: nrmt (homo sapiens) (aka n-terminal xaa-pro-lys n-methyltransferase 1)
D: nicotinamide n-methy... | [D; D] |
<Instruct>: Given the context 'Human liver NNMT activity has a bimodal frequency distribution, an observation which raises the possibility that this enzyme activity might be regulated by a genetic polymorphism, a polymorphism that could have functional implications for individual differences in drug and xenobiotic toxi... | <Mentions>: [nnmt]
<Options>: A: nnt (homo sapiens) (aka nicotinamide nucleotide transhydrogenase)
B: nnt (mus musculus) (aka nicotinamide nucleotide transhydrogenase)
C: nrmt (homo sapiens) (aka n-terminal xaa-pro-lys n-methyltransferase 1)
D: nnmt (mus musculus) (aka nicotinamide n-methyltransferase)
E: nnmt (homo sa... | [E] |
<Instruct>: Given the context 'As a first step toward testing that hypothesis, we set out to clone and express a cDNA for human liver NNMT.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nnmt]
<Options>: A: nnmt (xenopus tropicalis) (provisional ortholog of nicotinamide n-methyltransferase (xenopus tropicalis)) (aka provisional ortholog of nicotinamide n-methyltransferase)
B: nicotinamide n-methyltransferase (homo sapiens) (aka nicotinamide n-methyltransferase)
C: nnt (homo sapiens) (aka n... | [B] |
<Instruct>: Given the context 'Human liver NNMT was partially purified, photoaffinity-labeled, subjected to limited proteolysis, and partial amino acid sequence information was obtained.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ... | <Mentions>: [nnmt]
<Options>: A: nnmt (rattus norvegicus) (aka nicotinamide n-methyltransferase)
B: nnt (mus musculus) (aka nicotinamide nucleotide transhydrogenase)
C: nnmt (homo sapiens) (aka nicotinamide n-methyltransferase)
D: nnmt (xenopus tropicalis) (provisional ortholog of nicotinamide n-methyltransferase (xeno... | [C] |
<Instruct>: Given the context 'The polymerase chain reaction was then used to amplify a 550-nucleotide sequence with human liver cDNA as template and primers designed on the basis of the NNMT amino acid sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the ... | <Mentions>: [nnmt]
<Options>: A: nicotinamide n-methyltransferase (homo sapiens) (aka nicotinamide n-methyltransferase)
B: nicotinamide n-methyltransferase (mus musculus) (aka nicotinamide n-methyltransferase)
C: nnmt (xenopus tropicalis) (provisional ortholog of nicotinamide n-methyltransferase (xenopus tropicalis)) (... | [A] |
<Instruct>: Given the context 'The 5'- and 3'-ends of a human liver NNMT cDNA were obtained by use of the rapid amplification of cDNA ends.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nnmt]
<Options>: A: nnt (mus musculus) (aka nicotinamide nucleotide transhydrogenase)
B: nnmt (xenopus tropicalis) (provisional ortholog of nicotinamide n-methyltransferase (xenopus tropicalis)) (aka provisional ortholog of nicotinamide n-methyltransferase)
C: nnmt (rattus norvegicus) (aka nicotinamide n-m... | [E] |
<Instruct>: Given the context 'The combined use of these approaches resulted in the isolation of a human liver NNMT cDNA that was 969 nucleotides in length, with a 792-nucleotide open reading frame that encoded a 264-amino acid protein with a calculated molecular mass of 29.6 kDa.', select the correct biomedical concep... | <Mentions>: [nnmt]
<Options>: A: nnt (homo sapiens) (aka nicotinamide nucleotide transhydrogenase)
B: nicotinamide n-methyltransferase (rattus norvegicus) (aka nicotinamide n-methyltransferase)
C: nnmt (mus musculus) (aka nicotinamide n-methyltransferase)
D: nnmt (xenopus tropicalis) (provisional ortholog of nicotinami... | [E] |
<Instruct>: Given the context 'The human liver NNMT cDNA was transcribed in vitro and translated with a reticulocyte lysate system to yield a protein with a molecular mass of approximately 29 kDa that comigrated during SDS-polyacrylamide gel electrophoresis with photoaffinity-labeled human liver NNMT.', select the corr... | <Mentions>: [nnmt]
<Options>: A: nnmt (mus musculus) (aka nicotinamide n-methyltransferase)
B: nicotinamide n-methyltransferase (homo sapiens) (aka nicotinamide n-methyltransferase)
C: nrmt (homo sapiens) (aka n-terminal xaa-pro-lys n-methyltransferase 1)
D: nnmt (rattus norvegicus) (aka nicotinamide n-methyltransferas... | [B] |
<Instruct>: Given the context 'The human liver NNMT cDNA was transcribed in vitro and translated with a reticulocyte lysate system to yield a protein with a molecular mass of approximately 29 kDa that comigrated during SDS-polyacrylamide gel electrophoresis with photoaffinity-labeled human liver NNMT.', select the corr... | <Mentions>: [nnmt]
<Options>: A: nnmt (xenopus tropicalis) (provisional ortholog of nicotinamide n-methyltransferase (xenopus tropicalis)) (aka provisional ortholog of nicotinamide n-methyltransferase)
B: nrmt (homo sapiens) (aka n-terminal xaa-pro-lys n-methyltransferase 1)
C: nnmt (rattus norvegicus) (aka nicotinamid... | [E] |
<Instruct>: Given the context 'The NNMT cDNA was also subcloned into the eukaryotic expression vector p91023(B).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nnmt]
<Options>: A: nnt (homo sapiens) (aka nicotinamide nucleotide transhydrogenase)
B: nnmt (homo sapiens) (aka nicotinamide n-methyltransferase)
C: nnmt (mus musculus) (aka nicotinamide n-methyltransferase)
D: nrmt (homo sapiens) (aka n-terminal xaa-pro-lys n-methyltransferase 1)
E: nicotinamide n-methy... | [B] |
<Instruct>: Given the context 'COS-1 cells transfected with this construct expressed a high level of NNMT enzymatic activity, and the biochemical properties of this activity were similar to those of human liver NNMT.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [nnmt]
<Options>: A: nicotinamide n-methyltransferase (rattus norvegicus) (aka nicotinamide n-methyltransferase)
B: nnt (homo sapiens) (aka nicotinamide nucleotide transhydrogenase)
C: nicotinamide n-methyltransferase (mus musculus) (aka nicotinamide n-methyltransferase)
D: nnt (mus musculus) (aka nicotinam... | [E] |
<Instruct>: Given the context 'Human liver NNMT and transfected COS-1 cell NNMT had apparent Km values for the two cosubstrates for the reaction, nicotinamide and S-adenosyl-L-methionine, of 0.43 and 0.38 mM and of 1.8 and 2.2 microM, respectively.', select the correct biomedical concept for each mention using the prov... | <Mentions>: [nnmt]
<Options>: A: nicotinamide n-methyltransferase (mus musculus) (aka nicotinamide n-methyltransferase)
B: nicotinamide n-methyltransferase (homo sapiens) (aka nicotinamide n-methyltransferase)
C: nnmt (rattus norvegicus) (aka nicotinamide n-methyltransferase)
D: nnt (homo sapiens) (aka nicotinamide nuc... | [B] |
<Instruct>: Given the context 'IC50 values for the inhibition of NNMT by N1-methylnicotinamide were 60 and 30 microns for human liver and COS-1 cell-expressed NNMT, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [nnmt]
<Options>: A: nnt (homo sapiens) (aka nicotinamide nucleotide transhydrogenase)
B: nnmt (homo sapiens) (aka nicotinamide n-methyltransferase)
C: nnt (mus musculus) (aka nicotinamide nucleotide transhydrogenase)
D: nrmt (homo sapiens) (aka n-terminal xaa-pro-lys n-methyltransferase 1)
E: nicotinamide ... | [B] |
<Instruct>: Given the context 'Cloning of a cDNA for human liver NNMT will help make it possible to test the hypothesis that inheritance may play a role in the regulation of individual differences in human liver NNMT activity.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [nnmt]
<Options>: A: nnmt (rattus norvegicus) (aka nicotinamide n-methyltransferase)
B: nnt (mus musculus) (aka nicotinamide nucleotide transhydrogenase)
C: nrmt (homo sapiens) (aka n-terminal xaa-pro-lys n-methyltransferase 1)
D: nnt (homo sapiens) (aka nicotinamide nucleotide transhydrogenase)
E: nnmt (ho... | [E] |
<Instruct>: Given the context 'Purification and characterization of the recombinant human calcium-binding S100 proteins CAPL and CACY.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [capl; cacy]
<Options>: A: caprin-2-like (xenopus laevis) (aka caprin-2-like)
B: cartilage-associated protein-like (bos taurus) (aka cartilage-associated protein-like)
C: capl (homo sapiens) (aka s100 calcium binding protein a4)
D: cacy (mus musculus) (aka s100 calcium binding protein a6 (calcyclin))
E: coy... | [C; I] |
<Instruct>: Given the context 'Purification and characterization of the recombinant human calcium-binding S100 proteins CAPL and CACY.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [capl; cacy]
<Options>: A: cky-1 (caenorhabditis elegans) (aka pas domain-containing protein cky-1)
B: cacy (homo sapiens) (aka s100 calcium binding protein a6)
C: caly (homo sapiens) (aka calcyon neuron specific vesicular protein)
D: capsl (homo sapiens) (aka calcyphosine like)
E: caca (homo sapiens) (aka ... | [J; B] |
<Instruct>: Given the context 'The S100 proteins CAPL and CACY are expressed in a tissue- and cell-specific manner and have been reported to be associated with the metastatic phenotype of tumor cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [capl; cacy]
<Options>: A: casy-1 (caenorhabditis elegans) (aka calsyntenin c-terminal domain-containing protein;secreted calsyntenin-1)
B: capl (mus musculus) (aka s100 calcium binding protein a4)
C: capl (homo sapiens) (aka s100 calcium binding protein a4)
D: cartilage-associated protein-like (bos taurus)... | [C; J] |
<Instruct>: Given the context 'The S100 proteins CAPL and CACY are expressed in a tissue- and cell-specific manner and have been reported to be associated with the metastatic phenotype of tumor cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [capl; cacy]
<Options>: A: caca (homo sapiens) (aka crystallin gamma d)
B: cmap-like (bos taurus) (aka cystatin f)
C: capn1 (homo sapiens) (aka calpain 1)
D: capl (homo sapiens) (aka s100 calcium binding protein a4)
E: caprin-2-like (xenopus laevis) (aka caprin-2-like)
F: cacy (homo sapiens) (aka s100 calci... | [D; F] |
<Instruct>: Given the context 'The isotherms show slight (CAPL, nH = 1.15) or pronounced (CACY, nH = 1.33) positive cooperativity with K0.5 values of 0.32 mM (CACY) and 0.15 mM (CAPL), indicating that the sites are of the low-affinity type.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [capl; cacy]
<Options>: A: cartilage-associated protein-like (bos taurus) (aka cartilage-associated protein-like)
B: capsl (homo sapiens) (aka calcyphosine like)
C: cacy (mus musculus) (aka s100 calcium binding protein a6 (calcyclin))
D: capl (homo sapiens) (aka s100 calcium binding protein a4)
E: cacy (hom... | [D; E] |
<Instruct>: Given the context 'The isotherms show slight (CAPL, nH = 1.15) or pronounced (CACY, nH = 1.33) positive cooperativity with K0.5 values of 0.32 mM (CACY) and 0.15 mM (CAPL), indicating that the sites are of the low-affinity type.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [capl; cacy]
<Options>: A: cacy (homo sapiens) (aka s100 calcium binding protein a6)
B: cacy (mus musculus) (aka s100 calcium binding protein a6 (calcyclin))
C: capl (homo sapiens) (aka s100 calcium binding protein a4)
D: capon (homo sapiens) (aka nitric oxide synthase 1 adaptor protein)
E: capn1 (homo sapi... | [C; A] |
<Instruct>: Given the context 'Conformational changes in the Tyr microenvironment of CACY indicate that Ca2+ binding induces a shift of Tyr to a less polar environment.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [cacy]
<Options>: A: cyy-1 (caenorhabditis elegans) (aka cyclin-y)
B: caly (homo sapiens) (aka calcyon neuron specific vesicular protein)
C: pas domain-containing protein cky-1 (caenorhabditis elegans) (aka pas domain-containing protein cky-1)
D: cacy (homo sapiens) (aka s100 calcium binding protein a6)
E: ... | [D] |
<Instruct>: Given the context 'The Ca(2+)-induced difference spectra of CAPL are about 3 times smaller than those of CACY, suggesting that the additional Tyr84 in CACY is much more sensitive to Ca2+ than the two Tyr residues conserved in both proteins.', select the correct biomedical concept for each mention using the ... | <Mentions>: [capl; cacy]
<Options>: A: cacy (homo sapiens) (aka s100 calcium binding protein a6)
B: capl (homo sapiens) (aka s100 calcium binding protein a4)
C: cmap-like (bos taurus) (aka cystatin f)
D: caprin-2-like (xenopus laevis) (aka caprin-2-like)
E: capsl (homo sapiens) (aka calcyphosine like)
F: ccny (homo sap... | [B; A] |
<Instruct>: Given the context 'The Ca(2+)-induced difference spectra of CAPL are about 3 times smaller than those of CACY, suggesting that the additional Tyr84 in CACY is much more sensitive to Ca2+ than the two Tyr residues conserved in both proteins.', select the correct biomedical concept for each mention using the ... | <Mentions>: [capl; cacy]
<Options>: A: cky-1 (caenorhabditis elegans) (aka pas domain-containing protein cky-1)
B: coy1 (homo sapiens) (aka cut like homeobox 1)
C: capsl (bos taurus) (aka calcyphosine like)
D: caprin-2-like (xenopus laevis) (aka caprin-2-like)
E: ccny (homo sapiens) (aka cyclin y)
F: capsl (homo sapien... | [H; J] |
<Instruct>: Given the context 'The Ca(2+)-induced difference spectra of CAPL are about 3 times smaller than those of CACY, suggesting that the additional Tyr84 in CACY is much more sensitive to Ca2+ than the two Tyr residues conserved in both proteins.', select the correct biomedical concept for each mention using the ... | <Mentions>: [capl; cacy]
<Options>: A: coy1 (homo sapiens) (aka cut like homeobox 1)
B: capn1 (homo sapiens) (aka calpain 1)
C: cacy (homo sapiens) (aka s100 calcium binding protein a6)
D: caly (homo sapiens) (aka calcyon neuron specific vesicular protein)
E: capsl (bos taurus) (aka calcyphosine like)
F: cacy (mus musc... | [I; C] |
<Instruct>: Given the context 'X-arrestin: a new retinal arrestin mapping to the X chromosome.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [x-arrestin]
<Options>: A: arrestin (xenopus laevis) (arrestin beta 1 l homeolog (xenopus laevis)) (aka arrestin beta 1 l homeolog)
B: arrestin (xenopus laevis) (arrestin beta 2 l homeolog (xenopus laevis)) (aka arrestin beta 2 l homeolog)
C: arrestin 3, retinal (x-arrestin) (xenopus tropicalis) (aka arrest... | [E] |
<Instruct>: Given the context 'Chromosomal mapping localized this new arrestin gene to the proximal long arm of the X chromosome, hence it was named X-arrestin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [x-arrestin]
<Options>: A: arrestin (xenopus laevis) (arrestin beta 1 s homeolog (xenopus laevis)) (aka arrestin beta 1 s homeolog)
B: arr (drosophila melanogaster) (arrestin 2 (drosophila melanogaster)) (aka arrestin 2)
C: arrestin (xenopus laevis) (arrestin beta 1 l homeolog (xenopus laevis)) (aka arresti... | [E] |
<Instruct>: Given the context 'Human G(olf) alpha: complementary deoxyribonucleic acid structure and expression in pancreatic islets and other tissues outside the olfactory neuroepithelium and central nervous system.
G(olf) alpha is a G-protein originally believed to mediate signal transduction exclusively within the o... | <Mentions>: [g(olf) alpha]
<Options>: A: guanine nucleotide-binding protein alpha-1 subunit (glycine max) (aka guanine nucleotide-binding protein alpha-1 subunit)
B: gnas/l (drosophila melanogaster) (g protein alpha subunit f (drosophila melanogaster)) (aka g protein alpha subunit f)
C: guanine nucleotide-binding prote... | [E] |
<Instruct>: Given the context 'Here we present evidence that G(olf) alpha is expressed in several other tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [g(olf) alpha]
<Options>: A: g protein alpha subunit (glycine max) (aka g protein alpha subunit)
B: g protein subunit alpha l (homo sapiens) (aka g protein subunit alpha l)
C: gnas/l (drosophila melanogaster) (g protein alpha subunit f (drosophila melanogaster)) (aka g protein alpha subunit f)
D: guanine nu... | [B] |
<Instruct>: Given the context 'The human isoform of G(olf) alpha was isolated from two human insulinoma cDNA libraries.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [g(olf) alpha]
<Options>: A: g(olf) (xenopus laevis) (g protein subunit alpha l l homeolog (xenopus laevis)) (aka g protein subunit alpha l l homeolog)
B: galpha(olf) (xenopus tropicalis) (aka g protein subunit alpha l)
C: guanine nucleotide-binding protein g(olf) subunit alpha-like (oryctolagus cuniculus) ... | [E] |
<Instruct>: Given the context 'Comparison of the human sequence with rat G(olf) alpha shows 91% nucleotide identity (within the coding region) and 99% identity at the amino acid level.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [g(olf) alpha]
<Options>: A: g protein subunit alpha l (homo sapiens) (aka g protein subunit alpha l)
B: guanine nucleotide-binding protein g(olf) subunit alpha-like (oryctolagus cuniculus) (aka guanine nucleotide-binding protein g(olf) subunit alpha-like)
C: galpha(olf) (xenopus tropicalis) (aka g protein ... | [A] |
<Instruct>: Given the context 'Northern and reverse transcriptase-polymerase chain reaction analyses indicated that G(olf) alpha is expressed in all human insulinomas examined thus far as well as in normal pancreatic islets.', select the correct biomedical concept for each mention using the provided options. Answer by ... | <Mentions>: [g(olf) alpha]
<Options>: A: galpha(olf) (xenopus laevis) (g protein subunit alpha l l homeolog (xenopus laevis)) (aka g protein subunit alpha l l homeolog)
B: g(olf) (xenopus laevis) (g protein subunit alpha l s homeolog (xenopus laevis)) (aka g protein subunit alpha l s homeolog)
C: galpha(olf) (xenopus t... | [D] |
<Instruct>: Given the context 'G(olf) alpha mRNA was also detected in testis, retina, brain, and liver.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [g(olf) alpha]
<Options>: A: g(olf) (xenopus laevis) (g protein subunit alpha l l homeolog (xenopus laevis)) (aka g protein subunit alpha l l homeolog)
B: galpha(olf) (xenopus tropicalis) (aka g protein subunit alpha l)
C: g protein alpha subunit (glycine max) (aka g protein alpha subunit)
D: gnas/l (drosop... | [E] |
<Instruct>: Given the context 'G(olf) alpha mRNA was also detected in testis, retina, brain, and liver.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [g(olf) alpha]
<Options>: A: galpha(olf) (xenopus tropicalis) (aka g protein subunit alpha l)
B: g(olf) (xenopus laevis) (g protein subunit alpha l l homeolog (xenopus laevis)) (aka g protein subunit alpha l l homeolog)
C: gnas/l (drosophila melanogaster) (g protein alpha subunit f (drosophila melanogaster)... | [E] |
<Instruct>: Given the context 'Western blot analysis of various mouse tissues demonstrated that the level of G(olf) alpha protein in islets is lower than that in the olfactory neuroepithelium and other parts of the brain; its expression in retina, lung, and spleen was moderately higher than that in islets, and its expr... | <Mentions>: [g(olf) alpha]
<Options>: A: guanine nucleotide-binding protein g(olf) subunit alpha-like (oryctolagus cuniculus) (aka guanine nucleotide-binding protein g(olf) subunit alpha-like)
B: g(olf) (xenopus laevis) (g protein subunit alpha l s homeolog (xenopus laevis)) (aka g protein subunit alpha l s homeolog)
C... | [D] |
<Instruct>: Given the context 'G(olf) alpha was also detected by immunohistochemistry in mouse islets, human insulinomas, the epithelial lining of mouse epididymis, photoreceptor cells of mouse retina, and mouse lung alveoli.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [g(olf) alpha]
<Options>: A: g protein subunit alpha l (homo sapiens) (aka g protein subunit alpha l)
B: g(olf) (xenopus laevis) (g protein subunit alpha l s homeolog (xenopus laevis)) (aka g protein subunit alpha l s homeolog)
C: gnas/l (drosophila melanogaster) (g protein alpha subunit f (drosophila melan... | [A] |
<Instruct>: Given the context 'These findings suggest a role for G(olf) alpha in a diverse population of cells located outside the olfactory neuroepithelium and central nervous system.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [g(olf) alpha]
<Options>: A: guanine nucleotide-binding protein alpha-1 subunit (glycine max) (aka guanine nucleotide-binding protein alpha-1 subunit)
B: gnas/l (drosophila melanogaster) (g protein alpha subunit f (drosophila melanogaster)) (aka g protein alpha subunit f)
C: g protein subunit alpha l (homo ... | [C] |
<Instruct>: Given the context 'Regions of similarity were also seen between the amino acid sequences of the 140-kDa subunit of RFC, poly(ADP-ribose) polymerase, and bacterial DNA ligases--possibly representing a conserved structural feature of these proteins that bind similar DNA substrates.', select the correct biomed... | <Mentions>: [140-kda subunit of rfc]
<Options>: A: rfc4 (saccharomyces cerevisiae s288c) (aka replication factor c subunit 4)
B: rfc40 (homo sapiens) (replication factor c subunit 2 (homo sapiens)) (aka replication factor c subunit 2)
C: rfc1 (saccharomyces cerevisiae s288c) (aka replication factor c subunit 1)
D: rfc ... | [E] |
<Instruct>: Given the context 'Molecular cloning and centrosomal localization of human caltractin.
Caltractin, a 20-kDa calcium-binding protein, was previously purified and cloned at the DNA level from the unicellular green alga Chlamydomonas.', select the correct biomedical concept for each mention using the provided ... | <Mentions>: [caltractin]
<Options>: A: caln (homo sapiens) (aka protein phosphatase 3 catalytic subunit alpha)
B: caltractin (xenopus tropicalis) (aka caltractin)
C: calt (homo sapiens) (aka centrin 2)
D: calbindin (xenopus tropicalis) (aka calbindin 1)
E: calbindin 2 (homo sapiens) (aka calbindin 2)
F: None of the abo... | [C] |
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