instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Here we report the characterization of a cDNA encoding a human caltractin that shares a high degree of amino acid identity (70%) with its algal counterpart.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [caltractin]
<Options>: A: calbindin (xenopus tropicalis) (aka calbindin 1)
B: calbindin 2 (homo sapiens) (aka calbindin 2)
C: calumenin (homo sapiens) (aka calumenin)
D: calt (homo sapiens) (aka centrin 2)
E: caltractin (xenopus tropicalis) (aka caltractin)
F: None of the above. | [D] |
<Instruct>: Given the context 'Caltractin was identified in both HeLa and BHK cells as a 21-kDa polypeptide specifically localized to the centrosome of interphase and mitotic cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [caltractin]
<Options>: A: caltractin (xenopus tropicalis) (aka caltractin)
B: calumenin (homo sapiens) (aka calumenin)
C: calbindin 1 (homo sapiens) (aka calbindin 1)
D: caln (homo sapiens) (aka protein phosphatase 3 catalytic subunit alpha)
E: calt (homo sapiens) (aka centrin 2)
F: None of the above. | [E] |
<Instruct>: Given the context 'The high level of conservation in the amino acid sequence of caltractin from algae to humans and its association with the major microtubule-organizing center in the cell suggest that caltractin plays a fundamental role in microtubule-organizing center structure and function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [caltractin]
<Options>: A: calt (homo sapiens) (aka centrin 2)
B: caltractin (xenopus laevis) (aka caltractin)
C: calbindin (xenopus tropicalis) (aka calbindin 1)
D: calbindin 1 (homo sapiens) (aka calbindin 1)
E: caltractin (xenopus tropicalis) (aka caltractin)
F: None of the above. | [A] |
<Instruct>: Given the context 'It has a RING finger motif present in a family of apparent DNA-binding proteins and is designated estrogen-responsive finger protein (efp).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [estrogen-responsive finger protein; efp]
<Options>: A: rlf zinc finger (homo sapiens) (aka rlf zinc finger)
B: efo2p (homo sapiens) (aka establishment of sister chromatid cohesion n-acetyltransferase 2)
C: efe (homo sapiens) (aka tafazzin, phospholipid-lysophospholipid transacylase)
D: ring finger protein 4 (homo sapiens) (aka ring finger protein 4)
E: efp (homo sapiens) (aka tripartite motif containing 25)
F: epfn (homo sapiens) (aka sp6 transcription factor)
G: finger4 (homo sapiens) (aka yip1 domain family member 4)
H: epf (homo sapiens) (aka heat shock protein family e (hsp10) member 1)
I: ring finger protein 5 (homo sapiens) (aka ring finger protein 5)
J: rnf (homo sapiens) (aka tripartite motif containing 31)
K: None of the above. | [E; E] |
<Instruct>: Given the context 'It has a RING finger motif present in a family of apparent DNA-binding proteins and is designated estrogen-responsive finger protein (efp).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [estrogen-responsive finger protein; efp]
<Options>: A: rlf zinc finger (homo sapiens) (aka rlf zinc finger)
B: rnf (homo sapiens) (aka tripartite motif containing 31)
C: efo2p (homo sapiens) (aka establishment of sister chromatid cohesion n-acetyltransferase 2)
D: epfn (homo sapiens) (aka sp6 transcription factor)
E: efe (homo sapiens) (aka tafazzin, phospholipid-lysophospholipid transacylase)
F: ring finger protein 5 (homo sapiens) (aka ring finger protein 5)
G: epf (homo sapiens) (aka heat shock protein family e (hsp10) member 1)
H: ring finger protein 4 (homo sapiens) (aka ring finger protein 4)
I: finger4 (homo sapiens) (aka yip1 domain family member 4)
J: None of the above. | [J; J] |
<Instruct>: Given the context 'It has a RING finger motif present in a family of apparent DNA-binding proteins and is designated estrogen-responsive finger protein (efp).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [estrogen-responsive finger protein; efp]
<Options>: A: ring finger protein 4 (homo sapiens) (aka ring finger protein 4)
B: efp (homo sapiens) (aka tripartite motif containing 25)
C: efc (homo sapiens) (aka regulatory factor x1)
D: efg1 (homo sapiens) (aka g elongation factor mitochondrial 1)
E: ring finger protein-like (bos taurus) (aka ring finger protein-like)
F: efp (escherichia coli str. k-12 substr. mg1655) (aka protein chain elongation factor ef-p)
G: finger4 (homo sapiens) (aka yip1 domain family member 4)
H: epfn (homo sapiens) (aka sp6 transcription factor)
I: rlf zinc finger (homo sapiens) (aka rlf zinc finger)
J: rnf (homo sapiens) (aka tripartite motif containing 31)
K: None of the above. | [B; B] |
<Instruct>: Given the context 'efp cDNA contains a consensus estrogen-responsive element at the 3' untranslated region that can act as a downstream estrogen-dependent enhancer.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [efp]
<Options>: A: efp (homo sapiens) (aka tripartite motif containing 25)
B: efc (homo sapiens) (aka regulatory factor x1)
C: efp (escherichia coli str. k-12 substr. mg1655) (aka protein chain elongation factor ef-p)
D: efp1 (homo sapiens) (aka thioredoxin domain containing 11)
E: epf (homo sapiens) (aka heat shock protein family e (hsp10) member 1)
F: None of the above. | [A] |
<Instruct>: Given the context 'Moreover, efp is regulated by estrogen as demonstrated at both the mRNA and the protein level in ER-positive cells derived from mammary gland.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [efp]
<Options>: A: epfn (homo sapiens) (aka sp6 transcription factor)
B: efo2p (homo sapiens) (aka establishment of sister chromatid cohesion n-acetyltransferase 2)
C: efp (homo sapiens) (aka tripartite motif containing 25)
D: efc (homo sapiens) (aka regulatory factor x1)
E: efp (escherichia coli str. k-12 substr. mg1655) (aka protein chain elongation factor ef-p)
F: None of the above. | [C] |
<Instruct>: Given the context 'These data suggest that efp may represent an estrogen-responsive transcription factor that mediates phenotypic expression of the diverse estrogen action.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [efp]
<Options>: A: efp (escherichia coli str. k-12 substr. mg1655) (aka protein chain elongation factor ef-p)
B: efp1 (homo sapiens) (aka thioredoxin domain containing 11)
C: epfn (homo sapiens) (aka sp6 transcription factor)
D: efe (homo sapiens) (aka tafazzin, phospholipid-lysophospholipid transacylase)
E: efp (homo sapiens) (aka tripartite motif containing 25)
F: None of the above. | [E] |
<Instruct>: Given the context 'A human mitochondrial ATP-dependent protease that is highly homologous to bacterial Lon protease.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lon protease]
<Options>: A: lon protease homolog, mitochondrial (caenorhabditis elegans) (aka lon protease homolog, mitochondrial)
B: lonpl (homo sapiens) (aka lon peptidase 2, peroxisomal)
C: lon-1 (caenorhabditis elegans) (aka protein lon-1;scp domain-containing protein)
D: lon (escherichia coli str. k-12 substr. mg1655) (aka lon protease)
E: lon peptidase 1, mitochondrial (homo sapiens) (aka lon peptidase 1, mitochondrial)
F: None of the above. | [D] |
<Instruct>: Given the context 'A single species of mRNA was found for this Lon protease in all human tissues examined.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lon protease]
<Options>: A: lon protease (drosophila melanogaster) (aka lon protease)
B: lon protease homolog, mitochondrial (caenorhabditis elegans) (aka lon protease homolog, mitochondrial)
C: lon protease (escherichia coli str. k-12 substr. mg1655) (aka lon protease)
D: lonp1 (homo sapiens) (aka lon peptidase 1, mitochondrial)
E: lon-1 (caenorhabditis elegans) (aka protein lon-1;scp domain-containing protein)
F: None of the above. | [D] |
<Instruct>: Given the context 'Immunofluorescence microscopy suggested a predominantly mitochondrial localization for the Lon protease in cultured human cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lon protease]
<Options>: A: lon protease (drosophila melanogaster) (aka lon protease)
B: lon (homo sapiens) (aka lon peptidase 1, mitochondrial)
C: lon (escherichia coli str. k-12 substr. mg1655) (aka lon protease)
D: lon protease homolog, mitochondrial (caenorhabditis elegans) (aka lon protease homolog, mitochondrial)
E: lonpl (homo sapiens) (aka lon peptidase 2, peroxisomal)
F: None of the above. | [B] |
<Instruct>: Given the context 'A truncated LON gene, in which translation was initiated at Met118 of the coding sequence, was expressed in Escherichia coli and produced a protease that degraded alpha-casein in vitro in an ATP-dependent manner and had other properties similar to E. coli Lon protease.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lon; lon protease]
<Options>: A: lon (drosophila melanogaster) (lon protease (drosophila melanogaster)) (aka lon protease)
B: lonpl (homo sapiens) (aka lon peptidase 2, peroxisomal)
C: lon (homo sapiens) (aka lon peptidase 1, mitochondrial)
D: lon protease homolog, mitochondrial (caenorhabditis elegans) (aka lon protease homolog, mitochondrial)
E: lon (escherichia coli str. k-12 substr. mg1655) (aka lon protease)
F: lon-1 (caenorhabditis elegans) (aka protein lon-1;scp domain-containing protein)
G: None of the above. | [E; E] |
<Instruct>: Given the context 'A truncated LON gene, in which translation was initiated at Met118 of the coding sequence, was expressed in Escherichia coli and produced a protease that degraded alpha-casein in vitro in an ATP-dependent manner and had other properties similar to E. coli Lon protease.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lon; lon protease]
<Options>: A: lon (homo sapiens) (aka lon peptidase 1, mitochondrial)
B: lon (drosophila melanogaster) (lon protease (drosophila melanogaster)) (aka lon protease)
C: lon protease homolog, mitochondrial (caenorhabditis elegans) (aka lon protease homolog, mitochondrial)
D: lon-1 (caenorhabditis elegans) (aka protein lon-1;scp domain-containing protein)
E: lonpl (homo sapiens) (aka lon peptidase 2, peroxisomal)
F: None of the above. | [F; F] |
<Instruct>: Given the context 'A truncated LON gene, in which translation was initiated at Met118 of the coding sequence, was expressed in Escherichia coli and produced a protease that degraded alpha-casein in vitro in an ATP-dependent manner and had other properties similar to E. coli Lon protease.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lon; lon protease]
<Options>: A: lon (homo sapiens) (aka lon peptidase 1, mitochondrial)
B: lon protease homolog, mitochondrial (caenorhabditis elegans) (aka lon protease homolog, mitochondrial)
C: lon (drosophila melanogaster) (lon protease (drosophila melanogaster)) (aka lon protease)
D: lon (escherichia coli str. k-12 substr. mg1655) (aka lon protease)
E: lon (mus musculus) (aka lon peptidase 1, mitochondrial)
F: lon protease (drosophila melanogaster) (aka lon protease)
G: lonpl (homo sapiens) (aka lon peptidase 2, peroxisomal)
H: lon-1 (caenorhabditis elegans) (aka protein lon-1;scp domain-containing protein)
I: None of the above. | [D; D] |
<Instruct>: Given the context 'We analyzed the entire amino acid sequences in an amyloid preparation and found, in addition to the major beta/A4-protein (A beta) fragment, two unknown peptides.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [beta/a4-protein; a beta]
<Options>: A: calcium voltage-gated channel auxiliary subunit beta 4 (homo sapiens) (aka calcium voltage-gated channel auxiliary subunit beta 4)
B: actr1b (homo sapiens) (aka actin related protein 1b)
C: adaptor related protein complex 4 subunit beta 1 (homo sapiens) (aka adaptor related protein complex 4 subunit beta 1)
D: tubb4a (homo sapiens) (aka tubulin beta 4a class iva)
E: arpn-beta (homo sapiens) (aka actin like 6a)
F: actin beta (homo sapiens) (aka actin beta)
G: adra1b (homo sapiens) (aka adrenoceptor alpha 1b)
H: a-beta (homo sapiens) (aka succinate-coa ligase adp-forming subunit beta)
I: ctnnb (homo sapiens) (aka catenin beta 1)
J: scs-betaa (homo sapiens) (aka succinate-coa ligase adp-forming subunit beta)
K: None of the above. | [K; K] |
<Instruct>: Given the context 'We analyzed the entire amino acid sequences in an amyloid preparation and found, in addition to the major beta/A4-protein (A beta) fragment, two unknown peptides.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [beta/a4-protein; a beta]
<Options>: A: scs-betaa (homo sapiens) (aka succinate-coa ligase adp-forming subunit beta)
B: tubb4a (homo sapiens) (aka tubulin beta 4a class iva)
C: actin beta (homo sapiens) (aka actin beta)
D: adra1b (homo sapiens) (aka adrenoceptor alpha 1b)
E: calcium voltage-gated channel auxiliary subunit beta 4 (homo sapiens) (aka calcium voltage-gated channel auxiliary subunit beta 4)
F: accbeta (homo sapiens) (aka acetyl-coa carboxylase beta)
G: a-beta (homo sapiens) (aka succinate-coa ligase adp-forming subunit beta)
H: ctnnb (homo sapiens) (aka catenin beta 1)
I: arpn-beta (homo sapiens) (aka actin like 6a)
J: vac-beta (homo sapiens) (aka annexin a8 like 1)
K: None of the above. | [K; K] |
<Instruct>: Given the context 'We tentatively named this 35-amino acid peptide NAC (non-A beta component of AD amyloid) and its precursor NACP.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nac; non-a beta component of ad amyloid; nacp]
<Options>: A: alzheimer disease 7 (homo sapiens) (aka alzheimer disease 7)
B: nac1a (homo sapiens) (aka sodium voltage-gated channel alpha subunit 4)
C: synuclein alpha (rattus norvegicus) (aka synuclein alpha)
D: naca (homo sapiens) (aka nascent polypeptide associated complex subunit alpha)
E: nascent polypeptide-associated complex nac (arabidopsis thaliana) (aka nascent polypeptide-associated complex nac)
F: nac domain protein nac1 (glycine max) (aka nac domain protein nac1)
G: nacb (homo sapiens) (aka basic transcription factor 3)
H: synuclein beta (homo sapiens) (aka synuclein beta)
I: adn (homo sapiens) (aka complement factor d)
J: nacp (homo sapiens) (aka synuclein alpha)
K: nacap1 (homo sapiens) (aka naca family member 4, pseudogene)
L: nac (escherichia coli str. k-12 substr. mg1655) (aka dna-binding transcriptional dual regulator nac)
M: None of the above. | [J; J; J] |
<Instruct>: Given the context 'We tentatively named this 35-amino acid peptide NAC (non-A beta component of AD amyloid) and its precursor NACP.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nac; non-a beta component of ad amyloid; nacp]
<Options>: A: adn (homo sapiens) (aka complement factor d)
B: alzheimer disease 8 (homo sapiens) (aka alzheimer disease 8)
C: naca (homo sapiens) (aka nascent polypeptide associated complex subunit alpha)
D: nacc1 (homo sapiens) (aka nucleus accumbens associated 1)
E: nacp (homo sapiens) (aka synuclein alpha)
F: adnp (homo sapiens) (aka activity dependent neuroprotector homeobox)
G: nac (escherichia coli str. k-12 substr. mg1655) (aka dna-binding transcriptional dual regulator nac)
H: nac (drosophila melanogaster) (nascent polypeptide associated complex protein alpha subunit (drosophila melanogaster)) (aka nascent polypeptide associated complex protein alpha subunit)
I: nacae (homo sapiens) (aka solute carrier family 3 member 2)
J: nascent polypeptide-associated complex nac (arabidopsis thaliana) (aka nascent polypeptide-associated complex nac)
K: synuclein beta (homo sapiens) (aka synuclein beta)
L: nacap1 (homo sapiens) (aka naca family member 4, pseudogene)
M: None of the above. | [E; E; E] |
<Instruct>: Given the context 'We tentatively named this 35-amino acid peptide NAC (non-A beta component of AD amyloid) and its precursor NACP.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nac; non-a beta component of ad amyloid; nacp]
<Options>: A: nacp (homo sapiens) (aka synuclein alpha)
B: nascent polypeptide-associated complex nac (arabidopsis thaliana) (aka nascent polypeptide-associated complex nac)
C: alzheimer disease 7 (homo sapiens) (aka alzheimer disease 7)
D: synuclein alpha (rattus norvegicus) (aka synuclein alpha)
E: nacc1 (homo sapiens) (aka nucleus accumbens associated 1)
F: nac (escherichia coli str. k-12 substr. mg1655) (aka dna-binding transcriptional dual regulator nac)
G: nac1a (homo sapiens) (aka sodium voltage-gated channel alpha subunit 4)
H: nac domain protein nac1 (glycine max) (aka nac domain protein nac1)
I: adn (homo sapiens) (aka complement factor d)
J: beta-naca (homo sapiens) (aka basic transcription factor 3)
K: abeta (homo sapiens) (aka amyloid beta precursor protein)
L: None of the above. | [A; A; A] |
<Instruct>: Given the context 'NAC is the second component, after A beta, identified chemically in the purified AD amyloid preparation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nac; a beta]
<Options>: A: nacae (homo sapiens) (aka solute carrier family 3 member 2)
B: accbeta (homo sapiens) (aka acetyl-coa carboxylase beta)
C: nacb (homo sapiens) (aka basic transcription factor 3)
D: nascent polypeptide-associated complex nac (arabidopsis thaliana) (aka nascent polypeptide-associated complex nac)
E: actin beta (homo sapiens) (aka actin beta)
F: nacc1 (homo sapiens) (aka nucleus accumbens associated 1)
G: adra1b (homo sapiens) (aka adrenoceptor alpha 1b)
H: cg-beta-a (homo sapiens) (aka chorionic gonadotropin subunit beta 7)
I: arpn-beta (homo sapiens) (aka actin like 6a)
J: nacp (homo sapiens) (aka synuclein alpha)
K: None of the above. | [J; K] |
<Instruct>: Given the context 'NAC is the second component, after A beta, identified chemically in the purified AD amyloid preparation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nac; a beta]
<Options>: A: nac1a (homo sapiens) (aka sodium voltage-gated channel alpha subunit 4)
B: adra1b (homo sapiens) (aka adrenoceptor alpha 1b)
C: actb (homo sapiens) (actin beta (homo sapiens)) (aka actin beta)
D: scs-betaa (homo sapiens) (aka succinate-coa ligase adp-forming subunit beta)
E: nacc1 (homo sapiens) (aka nucleus accumbens associated 1)
F: nacae (homo sapiens) (aka solute carrier family 3 member 2)
G: naca (homo sapiens) (aka nascent polypeptide associated complex subunit alpha)
H: actr1b (homo sapiens) (aka actin related protein 1b)
I: arpn-beta (homo sapiens) (aka actin like 6a)
J: nacp (homo sapiens) (aka synuclein alpha)
K: None of the above. | [J; K] |
<Instruct>: Given the context 'Secondary structure predictions indicate that the NAC peptide sequence has a strong tendency to form beta-structures consistent with its association with amyloid.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nac]
<Options>: A: nacae (homo sapiens) (aka solute carrier family 3 member 2)
B: naca (homo sapiens) (aka nascent polypeptide associated complex subunit alpha)
C: nacp (homo sapiens) (aka synuclein alpha)
D: nac1a (homo sapiens) (aka sodium voltage-gated channel alpha subunit 4)
E: nacc1 (homo sapiens) (aka nucleus accumbens associated 1)
F: None of the above. | [C] |
<Instruct>: Given the context 'Secondary structure predictions indicate that the NAC peptide sequence has a strong tendency to form beta-structures consistent with its association with amyloid.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nac]
<Options>: A: nacc1 (homo sapiens) (aka nucleus accumbens associated 1)
B: nacae (homo sapiens) (aka solute carrier family 3 member 2)
C: naca (homo sapiens) (aka nascent polypeptide associated complex subunit alpha)
D: nac1a (homo sapiens) (aka sodium voltage-gated channel alpha subunit 4)
E: None of the above. | [E] |
<Instruct>: Given the context 'NACP is detected as a M(r) 19,000 protein in the cytosolic fraction of brain homogenates and comigrates on immunoblots with NACP synthesized in Escherichia coli from NACP cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nacp]
<Options>: A: nascent polypeptide-associated complex nac (arabidopsis thaliana) (aka nascent polypeptide-associated complex nac)
B: nacp (homo sapiens) (aka synuclein alpha)
C: naca (homo sapiens) (aka nascent polypeptide associated complex subunit alpha)
D: nac domain protein nac1 (glycine max) (aka nac domain protein nac1)
E: nacc1 (homo sapiens) (aka nucleus accumbens associated 1)
F: None of the above. | [B] |
<Instruct>: Given the context 'NACP mRNA is expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver, suggesting its ubiquitous and brain-specific functions.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nacp]
<Options>: A: nascent polypeptide-associated complex nac (arabidopsis thaliana) (aka nascent polypeptide-associated complex nac)
B: nacb (homo sapiens) (aka basic transcription factor 3)
C: nacp (homo sapiens) (aka synuclein alpha)
D: nac domain protein nac1 (glycine max) (aka nac domain protein nac1)
E: naca (homo sapiens) (aka nascent polypeptide associated complex subunit alpha)
F: None of the above. | [C] |
<Instruct>: Given the context 'The availability of the cDNA encoding full-length NACP should help to elucidate the mechanisms of amyloidosis in AD.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nacp]
<Options>: A: nacp (homo sapiens) (aka synuclein alpha)
B: nac1a (homo sapiens) (aka sodium voltage-gated channel alpha subunit 4)
C: nacb (homo sapiens) (aka basic transcription factor 3)
D: naca (homo sapiens) (aka nascent polypeptide associated complex subunit alpha)
E: nac (drosophila melanogaster) (nascent polypeptide associated complex protein alpha subunit (drosophila melanogaster)) (aka nascent polypeptide associated complex protein alpha subunit)
F: None of the above. | [A] |
<Instruct>: Given the context 'Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nrf1]
<Options>: A: nrf1 (rattus norvegicus) (aka nuclear respiratory factor 1)
B: nuclear respiratory factor 1 (homo sapiens) (aka nuclear respiratory factor 1)
C: nrf (homo sapiens) (aka nfkb repressing factor)
D: nrf-1 (homo sapiens) (aka nfe2 like bzip transcription factor 1)
E: nrf2a (homo sapiens) (aka ga binding protein transcription factor subunit alpha)
F: None of the above. | [D] |
<Instruct>: Given the context 'We have devised a complementation assay in yeast to clone mammalian transcriptional activators and have used it to identify a human basic leucine-zipper transcription factor that we have designated Nrf1 for NF-E2-related factor 1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nrf1; nf-e2-related factor 1]
<Options>: A: nrbf1 (homo sapiens) (aka mitochondrial trans-2-enoyl-coa reductase)
B: nfe2l1 (rattus norvegicus) (aka nfe2 like bzip transcription factor 1)
C: nfe2 (homo sapiens) (aka nuclear factor, erythroid 2)
D: nrf1 (homo sapiens) (nuclear respiratory factor 1 (homo sapiens)) (aka nuclear respiratory factor 1)
E: nrf-1 (homo sapiens) (aka nfe2 like bzip transcription factor 1)
F: nuclear factor, erythroid derived 2,-like 1 (mus musculus) (aka nuclear factor, erythroid derived 2,-like 1)
G: nrf2a (homo sapiens) (aka ga binding protein transcription factor subunit alpha)
H: nuclear factor, erythroid 2 like 1 (gallus gallus) (aka nuclear factor, erythroid 2 like 1)
I: nrf (homo sapiens) (aka nfkb repressing factor)
J: None of the above. | [E; E] |
<Instruct>: Given the context 'We have devised a complementation assay in yeast to clone mammalian transcriptional activators and have used it to identify a human basic leucine-zipper transcription factor that we have designated Nrf1 for NF-E2-related factor 1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nrf1; nf-e2-related factor 1]
<Options>: A: nfe2 (homo sapiens) (aka nuclear factor, erythroid 2)
B: nfe2l1_retired (rattus norvegicus) (aka nuclear respiratory factor 1)
C: nuclear factor, erythroid derived 2,-like 1 (mus musculus) (aka nuclear factor, erythroid derived 2,-like 1)
D: nrff (escherichia coli str. k-12 substr. mg1655) (aka putative formate-dependent nitrite reductase complex subunit nrff)
E: nuclear factor, erythroid 2 like 1 (gallus gallus) (aka nuclear factor, erythroid 2 like 1)
F: nrf-1 (homo sapiens) (aka nfe2 like bzip transcription factor 1)
G: nrf-1 (xenopus tropicalis) (aka nuclear respiratory factor 1)
H: nrbf1 (homo sapiens) (aka mitochondrial trans-2-enoyl-coa reductase)
I: nrf2a (homo sapiens) (aka ga binding protein transcription factor subunit alpha)
J: None of the above. | [F; F] |
<Instruct>: Given the context 'Nrf1 potentially encodes a 742-aa protein and displays marked homology to the mouse and human NF-E2 transcription factors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nrf1]
<Options>: A: nrff (escherichia coli str. k-12 substr. mg1655) (aka putative formate-dependent nitrite reductase complex subunit nrff)
B: nuclear respiratory factor 1 (homo sapiens) (aka nuclear respiratory factor 1)
C: nrf (homo sapiens) (aka nfkb repressing factor)
D: nrf-1 (homo sapiens) (aka nfe2 like bzip transcription factor 1)
E: nrf1 (rattus norvegicus) (aka nuclear respiratory factor 1)
F: None of the above. | [D] |
<Instruct>: Given the context 'Nrf1 activates transcription via NF-E2 binding sites in yeast cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nrf1]
<Options>: A: nrf-1 (homo sapiens) (aka nfe2 like bzip transcription factor 1)
B: nrbf1 (homo sapiens) (aka mitochondrial trans-2-enoyl-coa reductase)
C: nrf-1 (xenopus tropicalis) (aka nuclear respiratory factor 1)
D: nrf1 (homo sapiens) (nuclear respiratory factor 1 (homo sapiens)) (aka nuclear respiratory factor 1)
E: nrf (homo sapiens) (aka nfkb repressing factor)
F: None of the above. | [A] |
<Instruct>: Given the context 'Nrf1 activates transcription via NF-E2 binding sites in yeast cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nrf1]
<Options>: A: nrf-1 (xenopus tropicalis) (aka nuclear respiratory factor 1)
B: nrbf1 (homo sapiens) (aka mitochondrial trans-2-enoyl-coa reductase)
C: nrf1 (homo sapiens) (nuclear respiratory factor 1 (homo sapiens)) (aka nuclear respiratory factor 1)
D: nrf (homo sapiens) (aka nfkb repressing factor)
E: None of the above. | [E] |
<Instruct>: Given the context 'The ubiquitous expression pattern of Nrf1 and the range of promoters containing the NF-E2 binding motif suggest that this gene may play a role in the regulation of heme synthesis and ferritin genes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nrf1]
<Options>: A: nrf1 (rattus norvegicus) (aka nuclear respiratory factor 1)
B: nrbf1 (homo sapiens) (aka mitochondrial trans-2-enoyl-coa reductase)
C: nrf-1 (homo sapiens) (aka nfe2 like bzip transcription factor 1)
D: nrf-1 (xenopus tropicalis) (aka nuclear respiratory factor 1)
E: nrf (homo sapiens) (aka nfkb repressing factor)
F: None of the above. | [C] |
<Instruct>: Given the context 'Recessive mutations in the gene encoding the beta-subunit of rod phosphodiesterase in patients with retinitis pigmentosa.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [beta-subunit of rod phosphodiesterase]
<Options>: A: phosphodiesterase 6b, cgmp, rod receptor, beta polypeptide (mus musculus) (aka phosphodiesterase 6b, cgmp, rod receptor, beta polypeptide)
B: pde6b (homo sapiens) (aka phosphodiesterase 6b)
C: pde3b (homo sapiens) (aka phosphodiesterase 3b)
D: phosphodiesterase 6b, cgmp-specific, rod, beta (danio rerio) (aka phosphodiesterase 6b, cgmp-specific, rod, beta)
E: pdeivb (homo sapiens) (aka phosphodiesterase 4b)
F: None of the above. | [B] |
<Instruct>: Given the context 'We have found four mutations in the human gene encoding the beta-subunit of rod cGMP phosphodiesterase (PDE beta) that cosegregate with autosomal recessive retinitis pigmentosa, a degenerative disease of photoreceptors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [beta-subunit of rod cgmp phosphodiesterase; pde beta]
<Options>: A: gmp-pdebeta (homo sapiens) (aka phosphodiesterase 6b)
B: pde7b (homo sapiens) (aka phosphodiesterase 7b)
C: pde3b (homo sapiens) (aka phosphodiesterase 3b)
D: pde8b (homo sapiens) (aka phosphodiesterase 8b)
E: phosphodiesterase 6b, cgmp, rod receptor, beta polypeptide (mus musculus) (aka phosphodiesterase 6b, cgmp, rod receptor, beta polypeptide)
F: pde1b (homo sapiens) (aka phosphodiesterase 1b)
G: None of the above. | [A; A] |
<Instruct>: Given the context 'We have found four mutations in the human gene encoding the beta-subunit of rod cGMP phosphodiesterase (PDE beta) that cosegregate with autosomal recessive retinitis pigmentosa, a degenerative disease of photoreceptors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [beta-subunit of rod cgmp phosphodiesterase; pde beta]
<Options>: A: pde1b (homo sapiens) (aka phosphodiesterase 1b)
B: pdeivb (homo sapiens) (aka phosphodiesterase 4b)
C: pde8b (homo sapiens) (aka phosphodiesterase 8b)
D: pde7b (homo sapiens) (aka phosphodiesterase 7b)
E: pdes1b (homo sapiens) (aka phosphodiesterase 1b)
F: phosphodiesterase 6b, cgmp, rod receptor, beta polypeptide (mus musculus) (aka phosphodiesterase 6b, cgmp, rod receptor, beta polypeptide)
G: pde3b (homo sapiens) (aka phosphodiesterase 3b)
H: pde6b (homo sapiens) (aka phosphodiesterase 6b)
I: None of the above. | [H; H] |
<Instruct>: Given the context 'PDE beta is the second member of the phototransduction cascade besides rhodopsin that is absent or altered as a cause of retinitis pigmentosa, suggesting that other members of this pathway may be defective in other forms of this disease.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pde beta; rhodopsin]
<Options>: A: rho (homo sapiens) (rhodopsin (homo sapiens)) (aka rhodopsin)
B: pde3b (homo sapiens) (aka phosphodiesterase 3b)
C: pde6b (homo sapiens) (aka phosphodiesterase 6b)
D: rhodopsin-1 (drosophila melanogaster) (aka neither inactivation nor afterpotential e)
E: rh (drosophila melanogaster) (rhodopsin 3 (drosophila melanogaster)) (aka rhodopsin 3)
F: pde1b (homo sapiens) (aka phosphodiesterase 1b)
G: retinal g protein coupled receptor (homo sapiens) (aka retinal g protein coupled receptor)
H: pde7b (homo sapiens) (aka phosphodiesterase 7b)
I: retinal pigment epithelium-derived rhodopsin homolog (bos taurus) (aka retinal pigment epithelium-derived rhodopsin homolog)
J: pde8b (homo sapiens) (aka phosphodiesterase 8b)
K: None of the above. | [C; A] |
<Instruct>: Given the context 'PDE beta is the second member of the phototransduction cascade besides rhodopsin that is absent or altered as a cause of retinitis pigmentosa, suggesting that other members of this pathway may be defective in other forms of this disease.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pde beta; rhodopsin]
<Options>: A: phosphodiesterase 3b (homo sapiens) (aka phosphodiesterase 3b)
B: pde7b (homo sapiens) (aka phosphodiesterase 7b)
C: rh (drosophila melanogaster) (rhodopsin 3 (drosophila melanogaster)) (aka rhodopsin 3)
D: rh (drosophila melanogaster) (rhodopsin 2 (drosophila melanogaster)) (aka rhodopsin 2)
E: rho (homo sapiens) (rhodopsin (homo sapiens)) (aka rhodopsin)
F: pde6b (homo sapiens) (aka phosphodiesterase 6b)
G: rhodopsin-1 (drosophila melanogaster) (aka neither inactivation nor afterpotential e)
H: pdeivb (homo sapiens) (aka phosphodiesterase 4b)
I: phosphodiesterase 1b (homo sapiens) (aka phosphodiesterase 1b)
J: retinal pigment epithelium-derived rhodopsin homolog (gallus gallus) (aka retinal pigment epithelium-derived rhodopsin homolog)
K: None of the above. | [F; E] |
<Instruct>: Given the context 'PDE beta is the second member of the phototransduction cascade besides rhodopsin that is absent or altered as a cause of retinitis pigmentosa, suggesting that other members of this pathway may be defective in other forms of this disease.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pde beta; rhodopsin]
<Options>: A: phosphodiesterase 3b (homo sapiens) (aka phosphodiesterase 3b)
B: retinal pigment epithelium-derived rhodopsin homolog (gallus gallus) (aka retinal pigment epithelium-derived rhodopsin homolog)
C: phosphodiesterase 1b (homo sapiens) (aka phosphodiesterase 1b)
D: rh (drosophila melanogaster) (rhodopsin 2 (drosophila melanogaster)) (aka rhodopsin 2)
E: rho (homo sapiens) (rhodopsin (homo sapiens)) (aka rhodopsin)
F: rhodopsin-1 (drosophila melanogaster) (aka neither inactivation nor afterpotential e)
G: pdeivb (homo sapiens) (aka phosphodiesterase 4b)
H: rh (drosophila melanogaster) (rhodopsin 3 (drosophila melanogaster)) (aka rhodopsin 3)
I: pde7b (homo sapiens) (aka phosphodiesterase 7b)
J: None of the above. | [J; E] |
<Instruct>: Given the context 'Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10 by fluorescence in situ hybridization.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c-rel; nf-kappa bp50; nf-kappa bp65; lyt-10]
<Options>: A: interleukin 10 (homo sapiens) (aka interleukin 10)
B: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
C: nuclear factor kappa b subunit 1 (homo sapiens) (aka nuclear factor kappa b subunit 1)
D: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
E: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
F: v-rel avian reticuloendotheliosis viral oncogene homolog (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog)
G: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit pseudogene)
H: nfkb-p105 (homo sapiens) (aka nuclear factor kappa b subunit 1)
I: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
J: lyt-10 (xenopus tropicalis) (aka nuclear factor of kappa light polypeptide gene enhancer in b-cells 2)
K: ilt10 (homo sapiens) (aka leukocyte immunoglobulin-like receptor pseudogene 2)
L: c-rel (xenopus laevis) (v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog (xenopus laevis)) (aka v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog)
M: v-rel avian reticuloendotheliosis viral oncogene homolog b (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog b)
N: rel (homo sapiens) (aka rel proto-oncogene, nf-kb subunit)
O: rel-b (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
P: lyt10 (homo sapiens) (aka nuclear factor kappa b subunit 2)
Q: None of the above. | [N; C; I; P] |
<Instruct>: Given the context 'Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10 by fluorescence in situ hybridization.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c-rel; nf-kappa bp50; nf-kappa bp65; lyt-10]
<Options>: A: v-rel avian reticuloendotheliosis viral oncogene homolog b (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog b)
B: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
C: c-rel (xenopus laevis) (v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog (xenopus laevis)) (aka v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog)
D: lyt10 (homo sapiens) (aka nuclear factor kappa b subunit 2)
E: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
F: rel (homo sapiens) (aka rel proto-oncogene, nf-kb subunit)
G: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
H: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
I: p65 (homo sapiens) (rela proto-oncogene, nf-kb subunit (homo sapiens)) (aka rela proto-oncogene, nf-kb subunit)
J: c-x-c motif chemokine ligand 10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
K: nuclear factor kappa b subunit 1 (homo sapiens) (aka nuclear factor kappa b subunit 1)
L: interleukin 10 (homo sapiens) (aka interleukin 10)
M: v-rel avian reticuloendotheliosis viral oncogene homolog (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog)
N: nf-kappa-b1 (homo sapiens) (aka nuclear factor kappa b subunit 1)
O: ilt10 (homo sapiens) (aka leukocyte immunoglobulin-like receptor pseudogene 2)
P: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit pseudogene)
Q: rel-b (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
R: None of the above. | [F; N; I; D] |
<Instruct>: Given the context 'Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10 by fluorescence in situ hybridization.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c-rel; nf-kappa bp50; nf-kappa bp65; lyt-10]
<Options>: A: p65 (homo sapiens) (rela proto-oncogene, nf-kb subunit (homo sapiens)) (aka rela proto-oncogene, nf-kb subunit)
B: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
C: c-rel (homo sapiens) (aka rel proto-oncogene, nf-kb subunit)
D: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
E: v-rel avian reticuloendotheliosis viral oncogene homolog (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog)
F: nf-kappab (homo sapiens) (aka nuclear factor kappa b subunit 1)
G: nkat-10 (homo sapiens) (aka killer cell immunoglobulin like receptor, three ig domains and short cytoplasmic tail 1)
H: rel-b (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
I: nf-kb2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
J: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
K: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit pseudogene)
L: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
M: lyt-10 (xenopus tropicalis) (aka nuclear factor of kappa light polypeptide gene enhancer in b-cells 2)
N: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
O: v-rel avian reticuloendotheliosis viral oncogene homolog b (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog b)
P: lyt-10 (homo sapiens) (aka nuclear factor kappa b subunit 2)
Q: nf-kb (homo sapiens) (aka nuclear factor kappa b subunit 1)
R: c-rel (xenopus laevis) (v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog (xenopus laevis)) (aka v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog)
S: None of the above. | [C; F; A; P] |
<Instruct>: Given the context 'Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10 by fluorescence in situ hybridization.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c-rel; nf-kappa bp50; nf-kappa bp65; lyt-10]
<Options>: A: nfkb-p105 (homo sapiens) (aka nuclear factor kappa b subunit 1)
B: ilt10 (homo sapiens) (aka leukocyte immunoglobulin-like receptor pseudogene 2)
C: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
D: v-rel avian reticuloendotheliosis viral oncogene homolog (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog)
E: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
F: p65 (homo sapiens) (rela proto-oncogene, nf-kb subunit (homo sapiens)) (aka rela proto-oncogene, nf-kb subunit)
G: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
H: lyt-10 (homo sapiens) (aka nuclear factor kappa b subunit 2)
I: rel (homo sapiens) (aka rel proto-oncogene, nf-kb subunit)
J: c-rel (xenopus laevis) (v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog (xenopus laevis)) (aka v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog)
K: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
L: v-rel avian reticuloendotheliosis viral oncogene homolog b (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog b)
M: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
N: c-x-c motif chemokine ligand 10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
O: nf-kappab (homo sapiens) (aka nuclear factor kappa b subunit 1)
P: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit pseudogene)
Q: None of the above. | [I; O; F; H] |
<Instruct>: Given the context 'We have used fluorescence in situ hybridization (FISH) to perform precise chromosomal mapping of the genes encoding the transcription factors c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c-rel; nf-kappa bp50; nf-kappa bp65; lyt-10]
<Options>: A: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit pseudogene)
B: lyt10 (homo sapiens) (aka nuclear factor kappa b subunit 2)
C: lyt-10 (xenopus tropicalis) (aka nuclear factor of kappa light polypeptide gene enhancer in b-cells 2)
D: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
E: p65 (homo sapiens) (rela proto-oncogene, nf-kb subunit (homo sapiens)) (aka rela proto-oncogene, nf-kb subunit)
F: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
G: v-rel avian reticuloendotheliosis viral oncogene homolog (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog)
H: c-rel (xenopus laevis) (v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog (xenopus laevis)) (aka v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog)
I: ilt10 (homo sapiens) (aka leukocyte immunoglobulin-like receptor pseudogene 2)
J: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
K: rel (homo sapiens) (aka rel proto-oncogene, nf-kb subunit)
L: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
M: nkat-10 (homo sapiens) (aka killer cell immunoglobulin like receptor, three ig domains and short cytoplasmic tail 1)
N: nfkb-p105 (homo sapiens) (aka nuclear factor kappa b subunit 1)
O: v-rel avian reticuloendotheliosis viral oncogene homolog b (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog b)
P: nf-kappa-b1 (homo sapiens) (aka nuclear factor kappa b subunit 1)
Q: relb (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
R: None of the above. | [K; P; E; B] |
<Instruct>: Given the context 'We have used fluorescence in situ hybridization (FISH) to perform precise chromosomal mapping of the genes encoding the transcription factors c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c-rel; nf-kappa bp50; nf-kappa bp65; lyt-10]
<Options>: A: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
B: nfkb-p105 (homo sapiens) (aka nuclear factor kappa b subunit 1)
C: nkat-10 (homo sapiens) (aka killer cell immunoglobulin like receptor, three ig domains and short cytoplasmic tail 1)
D: p65 (homo sapiens) (rela proto-oncogene, nf-kb subunit (homo sapiens)) (aka rela proto-oncogene, nf-kb subunit)
E: v-rel avian reticuloendotheliosis viral oncogene homolog b (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog b)
F: lyt-10 (xenopus tropicalis) (aka nuclear factor of kappa light polypeptide gene enhancer in b-cells 2)
G: ilt10 (homo sapiens) (aka leukocyte immunoglobulin-like receptor pseudogene 2)
H: c-rel (xenopus laevis) (v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog (xenopus laevis)) (aka v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog)
I: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit pseudogene)
J: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
K: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
L: v-rel avian reticuloendotheliosis viral oncogene homolog (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog)
M: rel (homo sapiens) (aka rel proto-oncogene, nf-kb subunit)
N: relb (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
O: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
P: nf-kappa-b1 (homo sapiens) (aka nuclear factor kappa b subunit 1)
Q: None of the above. | [M; P; D; Q] |
<Instruct>: Given the context 'We have used fluorescence in situ hybridization (FISH) to perform precise chromosomal mapping of the genes encoding the transcription factors c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c-rel; nf-kappa bp50; nf-kappa bp65; lyt-10]
<Options>: A: c-rel (xenopus laevis) (v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog (xenopus laevis)) (aka v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog)
B: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
C: nf-kb (homo sapiens) (aka nuclear factor kappa b subunit 1)
D: nf-kappa-b1 (homo sapiens) (aka nuclear factor kappa b subunit 1)
E: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
F: v-rel avian reticuloendotheliosis viral oncogene homolog (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog)
G: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
H: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
I: lyt-10 (xenopus tropicalis) (aka nuclear factor of kappa light polypeptide gene enhancer in b-cells 2)
J: p65 (homo sapiens) (rela proto-oncogene, nf-kb subunit (homo sapiens)) (aka rela proto-oncogene, nf-kb subunit)
K: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit pseudogene)
L: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
M: nf-kb2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
N: rel proto-oncogene, nf-kb subunit (homo sapiens) (aka rel proto-oncogene, nf-kb subunit)
O: v-rel avian reticuloendotheliosis viral oncogene homolog b (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog b)
P: lyt10 (homo sapiens) (aka nuclear factor kappa b subunit 2)
Q: i-rel (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
R: nkat-10 (homo sapiens) (aka killer cell immunoglobulin like receptor, three ig domains and short cytoplasmic tail 1)
S: None of the above. | [N; D; J; P] |
<Instruct>: Given the context 'We have used fluorescence in situ hybridization (FISH) to perform precise chromosomal mapping of the genes encoding the transcription factors c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c-rel; nf-kappa bp50; nf-kappa bp65; lyt-10]
<Options>: A: v-rel avian reticuloendotheliosis viral oncogene homolog b (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog b)
B: c-rel (xenopus laevis) (v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog (xenopus laevis)) (aka v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog)
C: nkat-10 (homo sapiens) (aka killer cell immunoglobulin like receptor, three ig domains and short cytoplasmic tail 1)
D: p65 (homo sapiens) (rela proto-oncogene, nf-kb subunit (homo sapiens)) (aka rela proto-oncogene, nf-kb subunit)
E: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
F: lyt-10 (homo sapiens) (aka nuclear factor kappa b subunit 2)
G: v-rel avian reticuloendotheliosis viral oncogene homolog (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog)
H: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
I: ilt10 (homo sapiens) (aka leukocyte immunoglobulin-like receptor pseudogene 2)
J: nfkb-p50 (homo sapiens) (aka nuclear factor kappa b subunit 1)
K: relb (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
L: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit pseudogene)
M: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
N: nf-kappa-b1 (homo sapiens) (aka nuclear factor kappa b subunit 1)
O: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
P: rel proto-oncogene, nf-kb subunit (homo sapiens) (aka rel proto-oncogene, nf-kb subunit)
Q: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
R: None of the above. | [P; N; D; F] |
<Instruct>: Given the context 'We have used fluorescence in situ hybridization (FISH) to perform precise chromosomal mapping of the genes encoding the transcription factors c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c-rel; nf-kappa bp50; nf-kappa bp65; lyt-10]
<Options>: A: ilt10 (homo sapiens) (aka leukocyte immunoglobulin-like receptor pseudogene 2)
B: nfkb-p50 (homo sapiens) (aka nuclear factor kappa b subunit 1)
C: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit pseudogene)
D: c-rel (homo sapiens) (aka rel proto-oncogene, nf-kb subunit)
E: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
F: lyt-10 (homo sapiens) (aka nuclear factor kappa b subunit 2)
G: v-rel avian reticuloendotheliosis viral oncogene homolog b (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog b)
H: interleukin 10 (homo sapiens) (aka interleukin 10)
I: nkat-10 (homo sapiens) (aka killer cell immunoglobulin like receptor, three ig domains and short cytoplasmic tail 1)
J: v-rel avian reticuloendotheliosis viral oncogene homolog (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog)
K: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
L: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
M: c-rel (xenopus laevis) (v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog (xenopus laevis)) (aka v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog)
N: nf-kappa-b1 (homo sapiens) (aka nuclear factor kappa b subunit 1)
O: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
P: None of the above. | [D; N; K; F] |
<Instruct>: Given the context 'The previously published assignments of c-rel and NF-kappa Bp50 have been refined to specific bands.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c-rel; nf-kappa bp50]
<Options>: A: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
B: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
C: i-rel (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
D: v-rel avian reticuloendotheliosis viral oncogene homolog b (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog b)
E: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit pseudogene)
F: c-rel (xenopus laevis) (v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog (xenopus laevis)) (aka v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog)
G: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
H: c-rel (homo sapiens) (aka rel proto-oncogene, nf-kb subunit)
I: v-rel avian reticuloendotheliosis viral oncogene homolog (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog)
J: nf-kb (homo sapiens) (aka nuclear factor kappa b subunit 1)
K: None of the above. | [H; J] |
<Instruct>: Given the context 'The previously published assignments of c-rel and NF-kappa Bp50 have been refined to specific bands.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c-rel; nf-kappa bp50]
<Options>: A: nfkb-p105 (homo sapiens) (aka nuclear factor kappa b subunit 1)
B: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
C: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit pseudogene)
D: rel proto-oncogene, nf-kb subunit (homo sapiens) (aka rel proto-oncogene, nf-kb subunit)
E: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
F: c-rel (xenopus laevis) (v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog (xenopus laevis)) (aka v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog)
G: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
H: v-rel avian reticuloendotheliosis viral oncogene homolog (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog)
I: v-rel avian reticuloendotheliosis viral oncogene homolog b (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog b)
J: None of the above. | [D; A] |
<Instruct>: Given the context 'The map position of lyt-10, inferred from its isolation from a t(10;14)(q24;q32) translocation, has been confirmed.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lyt-10]
<Options>: A: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
B: lyt10 (homo sapiens) (aka nuclear factor kappa b subunit 2)
C: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
D: ilt10 (homo sapiens) (aka leukocyte immunoglobulin-like receptor pseudogene 2)
E: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
F: None of the above. | [B] |
<Instruct>: Given the context 'NF-kappa Bp65 has now been mapped to 11q13, a site of frequent involvement in aberration in multiple tumor types.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nf-kappa bp65]
<Options>: A: p65 (homo sapiens) (rela proto-oncogene, nf-kb subunit (homo sapiens)) (aka rela proto-oncogene, nf-kb subunit)
B: nf-kb2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
C: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit pseudogene)
D: nfkb-p105 (homo sapiens) (aka nuclear factor kappa b subunit 1)
E: None of the above. | [A] |
<Instruct>: Given the context 'Cloning, sequencing and expression of a cDNA encoding mammalian valyl-tRNA synthetase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [valyl-trna synthetase]
<Options>: A: valyl-trna synthetase 1 (bos taurus) (aka valyl-trna synthetase 1)
B: valyl-trna synthetase / valine-trna ligase-like protein (arabidopsis thaliana) (aka valyl-trna synthetase / valine-trna ligase-like protein)
C: valyl-trna synthetase 1 (homo sapiens) (aka valyl-trna synthetase 1)
D: valine--trna ligase (saccharomyces cerevisiae s288c) (aka valine--trna ligase)
E: valyl trna synthetase (arabidopsis thaliana) (aka valyl-trna synthetase / valine-trna ligase (valrs))
F: None of the above. | [C] |
<Instruct>: Given the context 'A fragment of the cDNA encoding a rat valyl-tRNA synthetase (TrsVal)-like protein was cloned from a rat cDNA library in lambda gt11 using an oligodeoxyribonucleotide (oligo) probe.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [valyl-trna synthetase; trsval]
<Options>: A: valyl-trna synthetase / valine-trna ligase-like protein (arabidopsis thaliana) (aka valyl-trna synthetase / valine-trna ligase-like protein)
B: valyl-trna synthetase / valine-trna ligase (valrs) (arabidopsis thaliana) (aka valyl-trna synthetase / valine-trna ligase (valrs))
C: valyl trna synthetase (arabidopsis thaliana) (aka valyl-trna synthetase / valine-trna ligase (valrs))
D: valyl-trna synthetase 1 (homo sapiens) (aka valyl-trna synthetase 1)
E: valyl-trna synthetase 1 (xenopus tropicalis) (aka valyl-trna synthetase 1)
F: vrs (drosophila melanogaster) (valyl-trna synthetase (drosophila melanogaster)) (aka valyl-trna synthetase)
G: valyl-trna synthetase 1 (bos taurus) (aka valyl-trna synthetase 1)
H: trsval (rattus norvegicus) (aka valyl-trna synthetase 1)
I: valyl-trna synthetase 1 (sus scrofa) (aka valyl-trna synthetase 1)
J: None of the above. | [H; H] |
<Instruct>: Given the context 'A fragment of the cDNA encoding a rat valyl-tRNA synthetase (TrsVal)-like protein was cloned from a rat cDNA library in lambda gt11 using an oligodeoxyribonucleotide (oligo) probe.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [valyl-trna synthetase; trsval]
<Options>: A: valine--trna ligase (saccharomyces cerevisiae s288c) (aka valine--trna ligase)
B: valyl-trna synthetase 1 (sus scrofa) (aka valyl-trna synthetase 1)
C: valyl-trna synthetase 1 (homo sapiens) (aka valyl-trna synthetase 1)
D: trsval (rattus norvegicus) (aka valyl-trna synthetase 1)
E: valyl-trna synthetase / valine-trna ligase-like protein (arabidopsis thaliana) (aka valyl-trna synthetase / valine-trna ligase-like protein)
F: valyl-trna synthetase / valine-trna ligase (valrs) (arabidopsis thaliana) (aka valyl-trna synthetase / valine-trna ligase (valrs))
G: valyl trna synthetase (arabidopsis thaliana) (aka valyl-trna synthetase / valine-trna ligase (valrs))
H: None of the above. | [D; D] |
<Instruct>: Given the context 'Three independent plaque clones containing the human TrsVal cDNA were then isolated from a lambda gt10 human erythroleukemia cDNA library using the rat cDNA fragment as the hybridization probe.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trsval]
<Options>: A: valyl-trna synthetase 1 (sus scrofa) (aka valyl-trna synthetase 1)
B: valine--trna ligase-like (gallus gallus) (aka valine--trna ligase-like)
C: valyl-trna synthetase 1 (homo sapiens) (aka valyl-trna synthetase 1)
D: valyl-trna synthetase 2, mitochondrial (bos taurus) (aka valyl-trna synthetase 2, mitochondrial)
E: valyl-trna synthetase / valine-trna ligase-like protein (arabidopsis thaliana) (aka valyl-trna synthetase / valine-trna ligase-like protein)
F: None of the above. | [C] |
<Instruct>: Given the context 'The deduced 1051-amino-acid sequence shares 65% identity with yeast TrsVal, and contains a highly basic N-terminal region, a newly evolved protease-sensitive region in sequence close to the C terminus, and several sites for protein kinase C phosphorylation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trsval]
<Options>: A: valyl-trna synthetase 2, mitochondrial (bos taurus) (aka valyl-trna synthetase 2, mitochondrial)
B: valyl-trna synthetase 1 (sus scrofa) (aka valyl-trna synthetase 1)
C: valine--trna ligase (saccharomyces cerevisiae s288c) (aka valine--trna ligase)
D: trsval (rattus norvegicus) (aka valyl-trna synthetase 1)
E: valyl-trna synthetase / valine-trna ligase (valrs) (arabidopsis thaliana) (aka valyl-trna synthetase / valine-trna ligase (valrs))
F: None of the above. | [C] |
<Instruct>: Given the context 'A 3-kb cDNA fragment was sub-cloned into plasmid pSVL and expressed in COS-7 cells; up to a sevenfold increase in TrsVal activity was obtained.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trsval]
<Options>: A: valine--trna ligase (saccharomyces cerevisiae s288c) (aka valine--trna ligase)
B: valyl-trna synthetase / valine-trna ligase (valrs) (arabidopsis thaliana) (aka valyl-trna synthetase / valine-trna ligase (valrs))
C: valyl-trna synthetase 1 (homo sapiens) (aka valyl-trna synthetase 1)
D: valyl-trna synthetase 1 (bos taurus) (aka valyl-trna synthetase 1)
E: valyl-trna synthetase 1 (xenopus tropicalis) (aka valyl-trna synthetase 1)
F: None of the above. | [C] |
<Instruct>: Given the context 'These results confirm the cloning and sequencing of a human TrsVal-encoding cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trsval]
<Options>: A: valine--trna ligase-like (gallus gallus) (aka valine--trna ligase-like)
B: valyl-trna synthetase 1 (homo sapiens) (aka valyl-trna synthetase 1)
C: valine--trna ligase (saccharomyces cerevisiae s288c) (aka valine--trna ligase)
D: trsval (rattus norvegicus) (aka valyl-trna synthetase 1)
E: valyl-trna synthetase / valine-trna ligase-like protein (arabidopsis thaliana) (aka valyl-trna synthetase / valine-trna ligase-like protein)
F: None of the above. | [B] |
<Instruct>: Given the context 'Localization of the intronless gene coding for calmodulin-like protein CLP to human chromosome 10p13-ter.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [calmodulin-like protein clp]
<Options>: A: calmodulin like 6 (homo sapiens) (aka calmodulin like 6)
B: calmodulin-like (glycine max) (aka calmodulin-like)
C: caml (homo sapiens) (aka calcium modulating ligand)
D: clp (homo sapiens) (calmodulin like 3 (homo sapiens)) (aka calmodulin like 3)
E: calponin-like proteins (caenorhabditis elegans) (aka calponin-like proteins)
F: None of the above. | [D] |
<Instruct>: Given the context 'The functional intronless gene coding for a calmodulin-like protein (CLP) has been localized to human chromosome 10p13-ter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [calmodulin-like protein; clp]
<Options>: A: clph (homo sapiens) (aka calcium binding protein, spermatid associated 1)
B: calmodulin-like protein;ef-hand domain-containing protein (caenorhabditis elegans) (aka calmodulin-like protein;ef-hand domain-containing protein)
C: clpx (homo sapiens) (aka caseinolytic mitochondrial matrix peptidase chaperone subunit x)
D: calmodulin-like 3 (mus musculus) (aka calmodulin-like 3)
E: calmodulin-like (bos taurus) (aka calmodulin-like)
F: clpp (homo sapiens) (aka caseinolytic mitochondrial matrix peptidase proteolytic subunit)
G: clps (homo sapiens) (aka colipase)
H: clpp (xenopus laevis) (aka caseinolytic mitochondrial matrix peptidase proteolytic subunit l homeolog)
I: camk-like (drosophila melanogaster) (aka uncharacterized protein)
J: calmodulin like 3 (homo sapiens) (aka calmodulin like 3)
K: None of the above. | [J; J] |
<Instruct>: Given the context 'The functional intronless gene coding for a calmodulin-like protein (CLP) has been localized to human chromosome 10p13-ter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [calmodulin-like protein; clp]
<Options>: A: clpp (homo sapiens) (aka caseinolytic mitochondrial matrix peptidase proteolytic subunit)
B: calmodulin-like 3 (mus musculus) (aka calmodulin-like 3)
C: calmodulin-like (bos taurus) (aka calmodulin-like)
D: calmodulin-like protein;ef-hand domain-containing protein (caenorhabditis elegans) (aka calmodulin-like protein;ef-hand domain-containing protein)
E: clpp (xenopus laevis) (aka caseinolytic mitochondrial matrix peptidase proteolytic subunit l homeolog)
F: clpx (homo sapiens) (aka caseinolytic mitochondrial matrix peptidase chaperone subunit x)
G: clps (homo sapiens) (aka colipase)
H: clph (homo sapiens) (aka calcium binding protein, spermatid associated 1)
I: camk-like (drosophila melanogaster) (aka uncharacterized protein)
J: None of the above. | [J; J] |
<Instruct>: Given the context 'The functional intronless gene coding for a calmodulin-like protein (CLP) has been localized to human chromosome 10p13-ter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [calmodulin-like protein; clp]
<Options>: A: calmodulin like 3 (homo sapiens) (aka calmodulin like 3)
B: clp-1 (homo sapiens) (aka cyclin and cbs domain divalent metal cation transport mediator 1)
C: calmodulin-like protein;ef-hand domain-containing protein (caenorhabditis elegans) (aka calmodulin-like protein;ef-hand domain-containing protein)
D: calmodulin-like 3 (mus musculus) (aka calmodulin-like 3)
E: calmodulin like 4 (homo sapiens) (aka calmodulin like 4)
F: calmodulin like 5 (homo sapiens) (aka calmodulin like 5)
G: clps (oryctolagus cuniculus) (aka colipase)
H: clpx (homo sapiens) (aka caseinolytic mitochondrial matrix peptidase chaperone subunit x)
I: clpa (homo sapiens) (aka t-box transcription factor 22)
J: clps (homo sapiens) (aka colipase)
K: None of the above. | [A; A] |
<Instruct>: Given the context 'Chromosomal assignment was performed by Southern blot analysis of DNA from human-rodent somatic cell hybrids and amplification of a CLP gene-specific 1090-bp DNA fragment by the polymerase chain reaction (PCR) on DNA from human-hamster cell hybrids.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [clp]
<Options>: A: clpp (oryctolagus cuniculus) (aka caseinolytic mitochondrial matrix peptidase proteolytic subunit)
B: clps (homo sapiens) (aka colipase)
C: clp-1 (homo sapiens) (aka cyclin and cbs domain divalent metal cation transport mediator 1)
D: clpx (homo sapiens) (aka caseinolytic mitochondrial matrix peptidase chaperone subunit x)
E: clpa (homo sapiens) (aka t-box transcription factor 22)
F: None of the above. | [F] |
<Instruct>: Given the context 'The CLP gene is the first member of the human calmodulin/calmodulin-like gene family to be chromosomally sublocalized.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [clp]
<Options>: A: clpp.l (xenopus laevis) (aka caseinolytic mitochondrial matrix peptidase proteolytic subunit l homeolog)
B: clph (homo sapiens) (aka calcium binding protein, spermatid associated 1)
C: clp-1 (homo sapiens) (aka cyclin and cbs domain divalent metal cation transport mediator 1)
D: clpp (oryctolagus cuniculus) (aka caseinolytic mitochondrial matrix peptidase proteolytic subunit)
E: clpp (homo sapiens) (aka caseinolytic mitochondrial matrix peptidase proteolytic subunit)
F: None of the above. | [F] |
<Instruct>: Given the context 'The generation of a human CLP gene-specific sequence tag site specified by the two primers used for PCR should prove useful for future linkage studies.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [clp]
<Options>: A: clpp (homo sapiens) (aka caseinolytic mitochondrial matrix peptidase proteolytic subunit)
B: clpp (oryctolagus cuniculus) (aka caseinolytic mitochondrial matrix peptidase proteolytic subunit)
C: clps (oryctolagus cuniculus) (aka colipase)
D: clph (homo sapiens) (aka calcium binding protein, spermatid associated 1)
E: clpa (homo sapiens) (aka t-box transcription factor 22)
F: None of the above. | [F] |
<Instruct>: Given the context 'A novel form of cytochrome P-450 family 4 in human polymorphonuclear leukocytes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cytochrome p-450 family 4]
<Options>: A: cytochrome p450 family 3 subfamily a member 4 (homo sapiens) (aka cytochrome p450 family 3 subfamily a member 4)
B: cyp4f44p (homo sapiens) (aka cytochrome p450 family 4 subfamily f member 44, pseudogene)
C: cytochrome p450, family 4, subfamily f, polypeptide 4 (rattus norvegicus) (aka cytochrome p450, family 4, subfamily f, polypeptide 4)
D: cytochrome p450 family 4 subfamily f member 2 (homo sapiens) (aka cytochrome p450 family 4 subfamily f member 2)
E: cyp4f3 (homo sapiens) (aka cytochrome p450 family 4 subfamily f member 3)
F: None of the above. | [E] |
<Instruct>: Given the context 'cDNA cloning and expression of leukotriene B4 omega-hydroxylase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [leukotriene b4 omega-hydroxylase]
<Options>: A: arachidonate 5-lipoxygenase (homo sapiens) (aka arachidonate 5-lipoxygenase)
B: arachidonate 15-lipoxygenase type b (homo sapiens) (aka arachidonate 15-lipoxygenase type b)
C: leukotriene a-4 hydrolase-like (glycine max) (aka leukotriene a-4 hydrolase-like)
D: ltb4dh (homo sapiens) (aka prostaglandin reductase 1)
E: ltb4h (homo sapiens) (aka cytochrome p450 family 4 subfamily f member 3)
F: None of the above. | [E] |
<Instruct>: Given the context 'Isolation of cDNA clones for human leukotriene B4 (LTB4) omega-hydroxylase clearly demonstrates that the hydroxylase is a member of the cytochrome P-450 (CYP) superfamily.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [leukotriene b4 (ltb4) omega-hydroxylase]
<Options>: A: lox4 (glycine max) (aka lipoxygenase)
B: ltb4dh (homo sapiens) (aka prostaglandin reductase 1)
C: leukotriene-b(4) omega-hydroxylase 2-like (bos taurus) (aka leukotriene-b(4) omega-hydroxylase 2-like)
D: cytochrome p450 2b4-like l homeolog (xenopus laevis) (aka cytochrome p450 2b4-like l homeolog)
E: ltb4h (homo sapiens) (aka cytochrome p450 family 4 subfamily f member 3)
F: None of the above. | [E] |
<Instruct>: Given the context 'The microsomes from yeast cells transfected with an expression vector pAAH5 carrying isolated cDNA catalyzed the omega-hydroxylation of LTB4 with a Km value of 0.71 microM, and its activity was significantly inhibited by carbon monoxide and by antisera against CYP4A4, consistent with the properties previously reported with LTB4 omega-hydroxylase in human polymorphonuclear leukocytes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ltb4 omega-hydroxylase]
<Options>: A: ltb4h (homo sapiens) (aka cytochrome p450 family 4 subfamily f member 3)
B: cyp2b4 (oryctolagus cuniculus) (aka cytochrome p450, family 2, subfamily b, polypeptide 4)
C: lta4h (homo sapiens) (aka leukotriene a4 hydrolase)
D: ltb4dh (homo sapiens) (aka prostaglandin reductase 1)
E: ltb4dh (oryctolagus cuniculus) (aka prostaglandin reductase 1)
F: None of the above. | [A] |
<Instruct>: Given the context 'The amino acid sequence of LTB4 omega-hydroxylase (P-450LTB omega) shows 31-44% similarity to those of CYP4A, CYP4B, and CYP4C, whereas less than 25% similarity was observed with any of the other P-450 families.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ltb4 omega-hydroxylase; p-450ltb omega]
<Options>: A: ltb4dh (oryctolagus cuniculus) (aka prostaglandin reductase 1)
B: cyp2b4 (oryctolagus cuniculus) (aka cytochrome p450, family 2, subfamily b, polypeptide 4)
C: cytochrome p450 2b4-like (xenopus tropicalis) (aka cytochrome p450 2b4-like)
D: arachidonate 5-lipoxygenase (homo sapiens) (aka arachidonate 5-lipoxygenase)
E: ltb4h (homo sapiens) (aka cytochrome p450 family 4 subfamily f member 3)
F: cyp2e (oryctolagus cuniculus) (aka cytochrome p450 2e1)
G: ltb4dh (homo sapiens) (aka prostaglandin reductase 1)
H: cytochrome p450 2c42-like (bos taurus) (aka cytochrome p450 2c42-like)
I: None of the above. | [E; E] |
<Instruct>: Given the context 'The amino acid sequence of LTB4 omega-hydroxylase (P-450LTB omega) shows 31-44% similarity to those of CYP4A, CYP4B, and CYP4C, whereas less than 25% similarity was observed with any of the other P-450 families.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ltb4 omega-hydroxylase; p-450ltb omega]
<Options>: A: 5-lox (homo sapiens) (aka arachidonate 5-lipoxygenase)
B: ltb4h (homo sapiens) (aka cytochrome p450 family 4 subfamily f member 3)
C: ltb4dh (homo sapiens) (aka prostaglandin reductase 1)
D: cytochrome p450 2c42-like (bos taurus) (aka cytochrome p450 2c42-like)
E: cytochrome p450 2b4-like (xenopus tropicalis) (aka cytochrome p450 2b4-like)
F: lta4h (homo sapiens) (aka leukotriene a4 hydrolase)
G: cyp2e (oryctolagus cuniculus) (aka cytochrome p450 2e1)
H: p450-lm2 (oryctolagus cuniculus) (aka cytochrome p450, family 2, subfamily b, polypeptide 4)
I: arachidonate 15-lipoxygenase type b (homo sapiens) (aka arachidonate 15-lipoxygenase type b)
J: None of the above. | [B; B] |
<Instruct>: Given the context 'According to the systematic classification of the P-450 superfamily, P-450LTB omega is classified into the CYP4 family but does not belong to any of the known CYP4 subfamilies.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p-450ltb omega]
<Options>: A: ltb4h (homo sapiens) (aka cytochrome p450 family 4 subfamily f member 3)
B: p-450ib (oryctolagus cuniculus) (aka cytochrome p450 family 2 subfamily j member 2)
C: cyp2b4 (oryctolagus cuniculus) (aka cytochrome p450, family 2, subfamily b, polypeptide 4)
D: cyp2e (oryctolagus cuniculus) (aka cytochrome p450 2e1)
E: cytochrome p450 2c42-like (bos taurus) (aka cytochrome p450 2c42-like)
F: None of the above. | [A] |
<Instruct>: Given the context 'Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase epsilon.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [catalytic subunit of human dna polymerase epsilon]
<Options>: A: dna polymerase eta (homo sapiens) (aka dna polymerase eta)
B: dna polymerase epsilon 4, accessory subunit (homo sapiens) (aka dna polymerase epsilon 4, accessory subunit)
C: dna polymerase epsilon, catalytic subunit (homo sapiens) (aka dna polymerase epsilon, catalytic subunit)
D: polymerase (dna directed), epsilon (mus musculus) (aka polymerase (dna directed), epsilon)
E: dna polymerase delta 1, catalytic subunit (homo sapiens) (aka dna polymerase delta 1, catalytic subunit)
F: None of the above. | [C] |
<Instruct>: Given the context 'The cDNA encoding the catalytic polypeptide of human DNA polymerase epsilon was cloned.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [catalytic polypeptide of human dna polymerase epsilon]
<Options>: A: dna polymerase epsilon catalytic subunit (saccharomyces cerevisiae s288c) (aka dna polymerase epsilon catalytic subunit)
B: dna polymerase epsilon 2, accessory subunit (homo sapiens) (aka dna polymerase epsilon 2, accessory subunit)
C: dna polymerase epsilon, catalytic subunit (homo sapiens) (aka dna polymerase epsilon, catalytic subunit)
D: dna polymerase gamma, catalytic subunit (homo sapiens) (aka dna polymerase gamma, catalytic subunit)
E: polymerase (dna directed), epsilon (mus musculus) (aka polymerase (dna directed), epsilon)
F: None of the above. | [C] |
<Instruct>: Given the context 'cDNA cloning and mitochondrial import of the beta-subunit of the human electron-transfer flavoprotein.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [beta-subunit of the human electron-transfer flavoprotein]
<Options>: A: electron transfer flavoprotein dehydrogenase (homo sapiens) (aka electron transfer flavoprotein dehydrogenase)
B: electron transfer flavoprotein subunit alpha (homo sapiens) (aka electron transfer flavoprotein subunit alpha)
C: electron transfer flavoprotein subunit beta (homo sapiens) (aka electron transfer flavoprotein subunit beta)
D: electron transferring flavoprotein, beta polypeptide (mus musculus) (aka electron transferring flavoprotein, beta polypeptide)
E: electron transfer flavoprotein subunit beta (bos taurus) (aka electron transfer flavoprotein subunit beta)
F: None of the above. | [C] |
<Instruct>: Given the context 'We have isolated a cDNA clone which encodes the entire beta-subunit of human electron-transferring flavoprotein (ETF) by screening an expression library from human liver using polyclonal antibodies against porcine ETF.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [beta-subunit of human electron-transferring flavoprotein]
<Options>: A: hydroxyacyl-coa dehydrogenase trifunctional multienzyme complex subunit beta (homo sapiens) (aka hydroxyacyl-coa dehydrogenase trifunctional multienzyme complex subunit beta)
B: etfb (homo sapiens) (aka electron transfer flavoprotein subunit beta)
C: electron transferring flavoprotein, beta polypeptide (mus musculus) (aka electron transferring flavoprotein, beta polypeptide)
D: electron transfer flavoprotein dehydrogenase (homo sapiens) (aka electron transfer flavoprotein dehydrogenase)
E: electron transfer flavoprotein subunit beta (xenopus tropicalis) (aka electron transfer flavoprotein subunit beta)
F: None of the above. | [B] |
<Instruct>: Given the context 'This cDNA encodes a protein of 255 amino-acid residues with a predicted molecular mass of 27,877 Da which shows a high degree of similarity with partial amino-acid sequences obtained from both rat liver and Paracoccus denitrificans beta-ETF.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [beta-etf]
<Options>: A: etf (homo sapiens) (aka tea domain transcription factor 2)
B: tcfeb (homo sapiens) (aka transcription factor eb)
C: etfrf1 (homo sapiens) (aka electron transfer flavoprotein regulatory factor 1)
D: etfb (homo sapiens) (aka electron transfer flavoprotein subunit beta)
E: etf1 (homo sapiens) (aka eukaryotic translation termination factor 1)
F: None of the above. | [D] |
<Instruct>: Given the context 'Northern-blot analysis shows that the human beta-ETF mRNA is approximately 1 kb in size and is abundant in liver, heart and skeletal muscle.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [beta-etf]
<Options>: A: electron transfer flavoprotein subunit beta (homo sapiens) (aka electron transfer flavoprotein subunit beta)
B: hrtef-1b (homo sapiens) (aka tea domain transcription factor 4)
C: tcfeb (homo sapiens) (aka transcription factor eb)
D: etfb (bos taurus) (aka electron transfer flavoprotein subunit beta)
E: ecgf-beta (homo sapiens) (aka fibroblast growth factor 1)
F: None of the above. | [A] |
<Instruct>: Given the context 'Northern-blot analysis shows that the human beta-ETF mRNA is approximately 1 kb in size and is abundant in liver, heart and skeletal muscle.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [beta-etf]
<Options>: A: ecgf-beta (homo sapiens) (aka fibroblast growth factor 1)
B: tcfeb (homo sapiens) (aka transcription factor eb)
C: etfb (bos taurus) (aka electron transfer flavoprotein subunit beta)
D: hrtef-1b (homo sapiens) (aka tea domain transcription factor 4)
E: None of the above. | [E] |
<Instruct>: Given the context 'Incubation with intact mitochondria indicates that the cDNA-encoded beta-ETF polypeptide contains the information necessary to reach the mitochondrial matrix.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [beta-etf]
<Options>: A: etf (homo sapiens) (aka tea domain transcription factor 2)
B: etfb (homo sapiens) (aka electron transfer flavoprotein subunit beta)
C: ebf (homo sapiens) (aka ebf transcription factor 1)
D: etfb (bos taurus) (aka electron transfer flavoprotein subunit beta)
E: ecgf-beta (homo sapiens) (aka fibroblast growth factor 1)
F: None of the above. | [B] |
<Instruct>: Given the context 'These data are in agreement with previous experiments suggesting that beta-ETF, unlike the majority of nuclear-encoded mitochondrial matrix proteins, does not have a cleavable leader peptide.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [beta-etf]
<Options>: A: etfrf1 (homo sapiens) (aka electron transfer flavoprotein regulatory factor 1)
B: etfb (bos taurus) (aka electron transfer flavoprotein subunit beta)
C: hrtef-1b (homo sapiens) (aka tea domain transcription factor 4)
D: etfb (homo sapiens) (aka electron transfer flavoprotein subunit beta)
E: etf1 (homo sapiens) (aka eukaryotic translation termination factor 1)
F: None of the above. | [D] |
<Instruct>: Given the context 'Interestingly, the sequence analysis of beta-ETF protein identifies a 26.3% identity with the Fix A gene product of the nitrogen-fixing bacterium Azorhizobium caulinodans.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [beta-etf]
<Options>: A: hrtef-1b (homo sapiens) (aka tea domain transcription factor 4)
B: ecgf-beta (homo sapiens) (aka fibroblast growth factor 1)
C: etfrf1 (homo sapiens) (aka electron transfer flavoprotein regulatory factor 1)
D: etf1 (homo sapiens) (aka eukaryotic translation termination factor 1)
E: electron transfer flavoprotein subunit beta (homo sapiens) (aka electron transfer flavoprotein subunit beta)
F: None of the above. | [E] |
<Instruct>: Given the context 'Human cDNAs for cytosolic and mitochondrial serine hydroxymethyltransferase (SHMT) were cloned by functional complementation of an Escherichia coli glyA mutant with a human cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [glya]
<Options>: A: glyoxalase i (glycine max) (aka lactoylglutathione lyase)
B: gsa (glycine max) (aka glutamate 1-semialdehyde aminotransferase)
C: glya (escherichia coli str. k-12 substr. mg1655) (aka serine hydroxymethyltransferase)
D: glya (homo sapiens) (aka serine hydroxymethyltransferase 2)
E: glyb (homo sapiens) (aka solute carrier family 25 member 32)
F: None of the above. | [C] |
<Instruct>: Given the context 'Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fkbp12]
<Options>: A: fkbp-12 (homo sapiens) (aka fkbp prolyl isomerase 1a)
B: fkbp22 (homo sapiens) (aka fkbp prolyl isomerase 14)
C: fkbp13 (homo sapiens) (aka fkbp prolyl isomerase 2)
D: fkbp-12 (oryctolagus cuniculus) (aka fkbp prolyl isomerase 1a)
E: fkbp-12 (xenopus tropicalis) (aka fkbp prolyl isomerase 1a)
F: None of the above. | [A] |
<Instruct>: Given the context 'CaN is the target of the immunosuppressive drugs cyclosporin A and FK506, which inhibit CaN after forming complexes with cytoplasmic binding proteins (cyclophilin and FKBP12, respectively).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fkbp12]
<Options>: A: fkbp22 (homo sapiens) (aka fkbp prolyl isomerase 14)
B: fkbp-12 (homo sapiens) (aka fkbp prolyl isomerase 1a)
C: fkbp13 (homo sapiens) (aka fkbp prolyl isomerase 2)
D: fkbp11 (homo sapiens) (aka fkbp prolyl isomerase 11)
E: fkbp-12 (xenopus tropicalis) (aka fkbp prolyl isomerase 1a)
F: None of the above. | [B] |
<Instruct>: Given the context 'We report here the crystal structures of full-length human CaN at 2.1 A resolution and of the complex of human CaN with FKBP12-FK506 at 3.5 A resolution.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fkbp12]
<Options>: A: fkbp22 (homo sapiens) (aka fkbp prolyl isomerase 14)
B: fkbp12.6 (homo sapiens) (aka fkbp prolyl isomerase 1b)
C: fkbp6 (homo sapiens) (aka fkbp prolyl isomerase family member 6 (inactive))
D: fkbp11 (homo sapiens) (aka fkbp prolyl isomerase 11)
E: fkbp-12 (homo sapiens) (aka fkbp prolyl isomerase 1a)
F: None of the above. | [E] |
<Instruct>: Given the context 'In the FKBP12-FK506-CaN complex, the auto-inhibitory element is displaced from the active site.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fkbp12]
<Options>: A: fkbp12 (homo sapiens) (fkbp prolyl isomerase 1a (homo sapiens)) (aka fkbp prolyl isomerase 1a)
B: fkbp22 (homo sapiens) (aka fkbp prolyl isomerase 14)
C: fkbpl (homo sapiens) (aka fkbp prolyl isomerase like)
D: fkbp6 (homo sapiens) (aka fkbp prolyl isomerase family member 6 (inactive))
E: fkbp12.6 (homo sapiens) (aka fkbp prolyl isomerase 1b)
F: None of the above. | [A] |
<Instruct>: Given the context 'The site of binding of FKBP12-FK506 appears to be shared by other non-competitive inhibitors of calcineurin, including a natural anchoring protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fkbp12]
<Options>: A: fkbp-12 (xenopus tropicalis) (aka fkbp prolyl isomerase 1a)
B: fkbp12.6 (homo sapiens) (aka fkbp prolyl isomerase 1b)
C: fkbp13 (homo sapiens) (aka fkbp prolyl isomerase 2)
D: fkbp12 (homo sapiens) (fkbp prolyl isomerase 1a (homo sapiens)) (aka fkbp prolyl isomerase 1a)
E: fkbp22 (homo sapiens) (aka fkbp prolyl isomerase 14)
F: None of the above. | [D] |
<Instruct>: Given the context 'HCC-1, a novel chemokine from human plasma.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hcc-1]
<Options>: A: hccs1 (homo sapiens) (aka vps53 subunit of garp complex)
B: hcc2 (homo sapiens) (aka thioredoxin domain containing 5)
C: hccr1 (homo sapiens) (aka letm1 domain containing 1)
D: hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
E: hcc3 (homo sapiens) (aka fun14 domain containing 2)
F: None of the above. | [D] |
<Instruct>: Given the context 'HCC-1, a novel chemokine from human plasma.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hcc-1]
<Options>: A: hccs1 (homo sapiens) (aka vps53 subunit of garp complex)
B: hcc3 (homo sapiens) (aka fun14 domain containing 2)
C: hcc2 (homo sapiens) (aka thioredoxin domain containing 5)
D: hccr1 (homo sapiens) (aka letm1 domain containing 1)
E: None of the above. | [E] |
<Instruct>: Given the context 'A novel CC chemokine, HCC-1, was isolated from the hemofiltrate of patients with chronic renal failure.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hcc-1]
<Options>: A: hcc5 (homo sapiens) (aka minichromosome maintenance complex component 3)
B: hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
C: hccs-1 (homo sapiens) (aka suppressor of tumorigenicity 20)
D: hcc2 (homo sapiens) (aka thioredoxin domain containing 5)
E: hccr1 (homo sapiens) (aka letm1 domain containing 1)
F: None of the above. | [B] |
<Instruct>: Given the context 'HCC-1 has a relative molecular mass of 8,673 and consists of 74 amino acids including four cysteines linked to disulfide bonds.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hcc-1]
<Options>: A: hcc5 (homo sapiens) (aka minichromosome maintenance complex component 3)
B: hcc2 (homo sapiens) (aka thioredoxin domain containing 5)
C: hcc3 (homo sapiens) (aka fun14 domain containing 2)
D: hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
E: hccr1 (homo sapiens) (aka letm1 domain containing 1)
F: None of the above. | [D] |
<Instruct>: Given the context 'HCC-1 cDNA was cloned from human bone marrow and shown to code for the mature protein plus a putative 19-residue leader sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hcc-1]
<Options>: A: hccs1 (homo sapiens) (aka vps53 subunit of garp complex)
B: hcca1 (homo sapiens) (aka yy1 associated protein 1)
C: hccs-1 (homo sapiens) (aka suppressor of tumorigenicity 20)
D: hccr1 (homo sapiens) (aka letm1 domain containing 1)
E: hcc-1/hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
F: None of the above. | [E] |
<Instruct>: Given the context 'Mature HCC-1 has sequence identity of 46% with macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta, and 29-37% with the other human CC chemokines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hcc-1; macrophage inflammatory protein (mip)-1 alpha; mip-1 beta]
<Options>: A: mcp-1 (homo sapiens) (aka c-c motif chemokine ligand 2)
B: mip-1-beta (homo sapiens) (c-c motif chemokine ligand 4 like 1 (homo sapiens)) (aka c-c motif chemokine ligand 4 like 1)
C: hccr1 (homo sapiens) (aka letm1 domain containing 1)
D: hccs1 (homo sapiens) (aka vps53 subunit of garp complex)
E: c-x3-c motif chemokine ligand 1 (homo sapiens) (aka c-x3-c motif chemokine ligand 1)
F: mip-1-alpha (homo sapiens) (aka c-c motif chemokine ligand 3)
G: mip1ap (homo sapiens) (aka c-c motif chemokine ligand 3 like 1)
H: mip-1-beta (xenopus tropicalis) (aka c-c motif chemokine ligand 4)
I: hcc3 (homo sapiens) (aka fun14 domain containing 2)
J: mip1b (homo sapiens) (aka c-c motif chemokine ligand 4)
K: mip-1d (homo sapiens) (aka c-c motif chemokine ligand 15)
L: hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
M: hccs-1 (homo sapiens) (aka suppressor of tumorigenicity 20)
N: mip-3a (homo sapiens) (aka c-c motif chemokine ligand 20)
O: None of the above. | [L; F; J] |
<Instruct>: Given the context 'Mature HCC-1 has sequence identity of 46% with macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta, and 29-37% with the other human CC chemokines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hcc-1; macrophage inflammatory protein (mip)-1 alpha; mip-1 beta]
<Options>: A: hcca1 (homo sapiens) (aka yy1 associated protein 1)
B: hcc3 (homo sapiens) (aka fun14 domain containing 2)
C: mip1ap (homo sapiens) (aka c-c motif chemokine ligand 3 like 1)
D: mip-1-alpha (homo sapiens) (aka c-c motif chemokine ligand 3)
E: hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
F: mip2b (homo sapiens) (aka c-x-c motif chemokine ligand 3)
G: mip-1-beta (xenopus tropicalis) (aka c-c motif chemokine ligand 4)
H: hccs1 (homo sapiens) (aka vps53 subunit of garp complex)
I: mip-1-beta (homo sapiens) (c-c motif chemokine ligand 4 like 1 (homo sapiens)) (aka c-c motif chemokine ligand 4 like 1)
J: c-x-c motif chemokine ligand 1 (homo sapiens) (aka c-x-c motif chemokine ligand 1)
K: mip-1-beta (homo sapiens) (c-c motif chemokine ligand 4 (homo sapiens)) (aka c-c motif chemokine ligand 4)
L: hccs-1 (homo sapiens) (aka suppressor of tumorigenicity 20)
M: mip1a (homo sapiens) (aka c-c motif chemokine ligand 3)
N: mip-3a (homo sapiens) (aka c-c motif chemokine ligand 20)
O: mcp-1 (homo sapiens) (aka c-c motif chemokine ligand 2)
P: None of the above. | [E; M; K] |
<Instruct>: Given the context 'Mature HCC-1 has sequence identity of 46% with macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta, and 29-37% with the other human CC chemokines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hcc-1; macrophage inflammatory protein (mip)-1 alpha; mip-1 beta]
<Options>: A: mcp-1 (homo sapiens) (aka c-c motif chemokine ligand 2)
B: mip-1d (homo sapiens) (aka c-c motif chemokine ligand 15)
C: hcc3 (homo sapiens) (aka fun14 domain containing 2)
D: hcc2 (homo sapiens) (aka thioredoxin domain containing 5)
E: mip-3b (homo sapiens) (aka c-c motif chemokine ligand 19)
F: mip-1-beta (homo sapiens) (c-c motif chemokine ligand 4 like 1 (homo sapiens)) (aka c-c motif chemokine ligand 4 like 1)
G: mip-3-alpha (homo sapiens) (aka c-c motif chemokine ligand 20)
H: c-x3-c motif chemokine ligand 1 (homo sapiens) (aka c-x3-c motif chemokine ligand 1)
I: hcc5 (homo sapiens) (aka minichromosome maintenance complex component 3)
J: mip-2b (homo sapiens) (aka c-x-c motif chemokine ligand 3)
K: hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
L: mip-1-beta (homo sapiens) (c-c motif chemokine ligand 4 (homo sapiens)) (aka c-c motif chemokine ligand 4)
M: hccs-1 (homo sapiens) (aka suppressor of tumorigenicity 20)
N: mip-1-alpha (homo sapiens) (aka c-c motif chemokine ligand 3)
O: None of the above. | [K; N; L] |
<Instruct>: Given the context 'Unlike MIP-1 alpha and the other CC chemokines, HCC-1 is expressed constitutively in several normal tissues (spleen, liver, skeletal and heart muscle, gut, and bone marrow), and is present at high concentrations (1-80 nM) in plasma.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mip-1 alpha; hcc-1]
<Options>: A: c-c motif chemokine ligand 1 (homo sapiens) (aka c-c motif chemokine ligand 1)
B: hcc5 (homo sapiens) (aka minichromosome maintenance complex component 3)
C: mip1b (homo sapiens) (aka c-c motif chemokine ligand 4)
D: mip1a (homo sapiens) (aka c-c motif chemokine ligand 3)
E: hcca1 (homo sapiens) (aka yy1 associated protein 1)
F: hccr1 (homo sapiens) (aka letm1 domain containing 1)
G: hcc2 (homo sapiens) (aka thioredoxin domain containing 5)
H: mip-3-alpha (homo sapiens) (aka c-c motif chemokine ligand 20)
I: hcc-1 (homo sapiens) (aka c-c motif chemokine ligand 14)
J: mip1ap (homo sapiens) (aka c-c motif chemokine ligand 3 like 1)
K: None of the above. | [D; I] |
<Instruct>: Given the context 'Unlike MIP-1 alpha and the other CC chemokines, HCC-1 is expressed constitutively in several normal tissues (spleen, liver, skeletal and heart muscle, gut, and bone marrow), and is present at high concentrations (1-80 nM) in plasma.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mip-1 alpha; hcc-1]
<Options>: A: mip-1-alpha (homo sapiens) (aka c-c motif chemokine ligand 3)
B: hcc5 (homo sapiens) (aka minichromosome maintenance complex component 3)
C: hcca1 (homo sapiens) (aka yy1 associated protein 1)
D: hcc2 (homo sapiens) (aka thioredoxin domain containing 5)
E: hccr1 (homo sapiens) (aka letm1 domain containing 1)
F: mip-4a (homo sapiens) (aka c-c motif chemokine ligand 26)
G: hcc-1 (homo sapiens) (aka c-c motif chemokine ligand 14)
H: c-x3-c motif chemokine ligand 1 (homo sapiens) (aka c-x3-c motif chemokine ligand 1)
I: mip1ap (homo sapiens) (aka c-c motif chemokine ligand 3 like 1)
J: mip-3-alpha (homo sapiens) (aka c-c motif chemokine ligand 20)
K: None of the above. | [A; G] |
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