instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'When coexpressed in transfected 293T cells, rab8 and the rab8ip/GC kinase formed a complex that could be recovered by immunoprecipitation with antibodies to rab8.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [rab8; rab8ip; gc kinase]
<Options>: A: gnk (homo sapiens) (aka n-acetylglucosamine kinase)
B: rab6ip1 (homo sapiens) (aka denn domain containing 5a)
C: serine/threonine-protein kinase gcn2 (saccharomyces cerevisiae s288c) (aka serine/threonine-protein kinase gcn2)
D: rab8ip (mus musculus) (aka mitogen-acti... | [E; D; G] |
<Instruct>: Given the context 'When coexpressed in transfected 293T cells, rab8 and the rab8ip/GC kinase formed a complex that could be recovered by immunoprecipitation with antibodies to rab8.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [rab8; rab8ip; gc kinase]
<Options>: A: gck (homo sapiens) (mitogen-activated protein kinase kinase kinase kinase 2 (homo sapiens)) (aka mitogen-activated protein kinase kinase kinase kinase 2)
B: gck-a (xenopus laevis) (aka glucokinase (hexokinase 4) l homeolog)
C: rab8 (drosophila melanogaster) (aka rab8)... | [I; L; A] |
<Instruct>: Given the context 'When coexpressed in transfected 293T cells, rab8 and the rab8ip/GC kinase formed a complex that could be recovered by immunoprecipitation with antibodies to rab8.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [rab8; rab8ip; gc kinase]
<Options>: A: rab6ip1 (homo sapiens) (aka denn domain containing 5a)
B: gck (homo sapiens) (mitogen-activated protein kinase kinase kinase kinase 2 (homo sapiens)) (aka mitogen-activated protein kinase kinase kinase kinase 2)
C: rab8a, member ras oncogene family (mus musculus) (aka... | [F; I; B] |
<Instruct>: Given the context 'Cell fractionation and immunofluorescence analyses indicate that in MDCK cells endogenous rab8ip is present both in the cytosol and as a peripheral membrane protein concentrated in the Golgi region and basolateral plasma membrane domains, sites where rab8 itself is also located.', select ... | <Mentions>: [rab8ip; rab8]
<Options>: A: rab3ip (homo sapiens) (aka rab3a interacting protein)
B: rab8b, member ras oncogene family (homo sapiens) (aka rab8b, member ras oncogene family)
C: rab8 (drosophila melanogaster) (aka rab8)
D: rab8ip (mus musculus) (aka mitogen-activated protein kinase kinase kinase kinase 2)
E... | [D; G] |
<Instruct>: Given the context 'Cell fractionation and immunofluorescence analyses indicate that in MDCK cells endogenous rab8ip is present both in the cytosol and as a peripheral membrane protein concentrated in the Golgi region and basolateral plasma membrane domains, sites where rab8 itself is also located.', select ... | <Mentions>: [rab8ip; rab8]
<Options>: A: rab8ipl1 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 3)
B: rab8a, member ras oncogene family (mus musculus) (aka rab8a, member ras oncogene family)
C: rab8a, member ras oncogene family l homeolog (xenopus laevis) (aka rab8a, member ras oncogene fami... | [F; E] |
<Instruct>: Given the context 'In light of recent evidence that rab proteins may act by promoting the stabilization of SNARE complexes, the specific GTP-dependent association of rab8 with the rab8ip/GC kinase raises the possibility that rab-regulated protein phosphorylation is important for vesicle targeting or fusion.... | <Mentions>: [rab8; rab8ip; gc kinase]
<Options>: A: rab8a, member ras oncogene family (mus musculus) (aka rab8a, member ras oncogene family)
B: rab8 (drosophila melanogaster) (aka rab8)
C: rabin8 (homo sapiens) (aka rab3a interacting protein)
D: rab8ipl1 (homo sapiens) (aka mitogen-activated protein kinase kinase kinas... | [H; O; G] |
<Instruct>: Given the context 'In light of recent evidence that rab proteins may act by promoting the stabilization of SNARE complexes, the specific GTP-dependent association of rab8 with the rab8ip/GC kinase raises the possibility that rab-regulated protein phosphorylation is important for vesicle targeting or fusion.... | <Mentions>: [rab8; rab8ip; gc kinase]
<Options>: A: rabin8 (homo sapiens) (aka rab3a interacting protein)
B: gck-1 (caenorhabditis elegans) (aka germinal center kinase 1;non-specific serine/threonine protein kinase)
C: rab8ipl1 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 3)
D: rab8ip (homo... | [G; N; H] |
<Instruct>: Given the context 'In light of recent evidence that rab proteins may act by promoting the stabilization of SNARE complexes, the specific GTP-dependent association of rab8 with the rab8ip/GC kinase raises the possibility that rab-regulated protein phosphorylation is important for vesicle targeting or fusion.... | <Mentions>: [rab8; rab8ip; gc kinase]
<Options>: A: rab8 (homo sapiens) (aka rab8a, member ras oncogene family)
B: rabin8 (homo sapiens) (aka rab3a interacting protein)
C: gck-2 (caenorhabditis elegans) (aka mitogen-activated protein kinase kinase kinase kinase)
D: rab8a, member ras oncogene family (mus musculus) (aka ... | [A; J; K] |
<Instruct>: Given the context 'Moreover, the rab8ip/GC kinase may serve to modulate secretion in response to stress stimuli.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rab8ip; gc kinase]
<Options>: A: rab8ipl1 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 3)
B: rab6ip1 (homo sapiens) (aka denn domain containing 5a)
C: serine/threonine-protein kinase gcn2 (saccharomyces cerevisiae s288c) (aka serine/threonine-protein kinase gcn2)
D: mcm8ip (hom... | [E; H] |
<Instruct>: Given the context 'Moreover, the rab8ip/GC kinase may serve to modulate secretion in response to stress stimuli.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rab8ip; gc kinase]
<Options>: A: rabin8 (homo sapiens) (aka rab3a interacting protein)
B: serine/threonine-protein kinase gcn2 (saccharomyces cerevisiae s288c) (aka serine/threonine-protein kinase gcn2)
C: gnk (homo sapiens) (aka n-acetylglucosamine kinase)
D: rab8ipl1 (homo sapiens) (aka mitogen-activated... | [J; G] |
<Instruct>: Given the context 'Moreover, the rab8ip/GC kinase may serve to modulate secretion in response to stress stimuli.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rab8ip; gc kinase]
<Options>: A: gnk (homo sapiens) (aka n-acetylglucosamine kinase)
B: mcm8ip (homo sapiens) (aka homologous recombination factor with ob-fold)
C: rab8ip (mus musculus) (aka mitogen-activated protein kinase kinase kinase kinase 2)
D: gck (xenopus tropicalis) (aka glucokinase (hexokinase 4)... | [C; H] |
<Instruct>: Given the context 'The contribution of the two transporter isoforms to monoamine storage in human neuroendocrine tissues was examined with isoform-specific polyclonal antibodies against hVMAT1 and hVMAT2.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [hvmat1; hvmat2]
<Options>: A: vmat2 (homo sapiens) (aka solute carrier family 18 member a2)
B: vmat2 (mus musculus) (aka solute carrier family 18 (vesicular monoamine), member 2)
C: vstm2 (homo sapiens) (aka v-set and transmembrane domain containing 2a)
D: hvt1 (arabidopsis thaliana) (aka helicase in vascu... | [H; A] |
<Instruct>: Given the context 'The contribution of the two transporter isoforms to monoamine storage in human neuroendocrine tissues was examined with isoform-specific polyclonal antibodies against hVMAT1 and hVMAT2.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [hvmat1; hvmat2]
<Options>: A: amino acid transporter avt1j (glycine max) (aka amino acid transporter avt1j)
B: solute carrier family 18 (vesicular monoamine), member 2 (mus musculus) (aka solute carrier family 18 (vesicular monoamine), member 2)
C: hvmt1 (mus musculus) (aka heavy metal tolerance protein 1)... | [H; G] |
<Instruct>: Given the context 'Central, peripheral, and enteric neurons express only VMAT2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vmat2]
<Options>: A: solute carrier family 18 (vesicular monoamine), member 2 (mus musculus) (aka solute carrier family 18 (vesicular monoamine), member 2)
B: eaat2 (homo sapiens) (aka solute carrier family 1 member 2)
C: vmat1 (homo sapiens) (aka solute carrier family 18 member a1)
D: vmat2 (homo sapiens)... | [D] |
<Instruct>: Given the context 'VMAT1 is expressed exclusively in neuroendocrine, including chromaffin and enterochromaffin, cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vmat1]
<Options>: A: vmat2 (homo sapiens) (aka solute carrier family 18 member a2)
B: solute carrier family 18 (vesicular monoamine), member 1 (mus musculus) (aka solute carrier family 18 (vesicular monoamine), member 1)
C: viaat (homo sapiens) (aka solute carrier family 32 member 1)
D: vesicle amine trans... | [E] |
<Instruct>: Given the context 'VMAT1 and VMAT2 are coexpressed in all chromaffin cells of the adrenal medulla.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vmat1; vmat2]
<Options>: A: vmat-2 (rattus norvegicus) (aka solute carrier family 18 member a2)
B: vat1 (homo sapiens) (solute carrier family 18 member a1 (homo sapiens)) (aka solute carrier family 18 member a1)
C: vmat2 (homo sapiens) (aka solute carrier family 18 member a2)
D: vmat-1 (rattus norvegicus) ... | [B; E] |
<Instruct>: Given the context 'VMAT1 and VMAT2 are coexpressed in all chromaffin cells of the adrenal medulla.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vmat1; vmat2]
<Options>: A: vat2 (homo sapiens) (aka solute carrier family 18 member a2)
B: solute carrier family 18 (vesicular monoamine), member 2 (mus musculus) (aka solute carrier family 18 (vesicular monoamine), member 2)
C: vmat-1 (rattus norvegicus) (aka solute carrier family 18 member a1)
D: vglut2... | [J; A] |
<Instruct>: Given the context 'VMAT1 and VMAT2 are coexpressed in all chromaffin cells of the adrenal medulla.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vmat1; vmat2]
<Options>: A: vglut2 (homo sapiens) (aka solute carrier family 17 member 6)
B: vesicle amine transport 1 (homo sapiens) (aka vesicle amine transport 1)
C: viaat (homo sapiens) (aka solute carrier family 32 member 1)
D: vat2 (homo sapiens) (aka solute carrier family 18 member a2)
E: vmat-1 (ra... | [G; D] |
<Instruct>: Given the context 'VMAT2 alone is expressed in histamine-storing enterochromaffin-like cells of the oxyntic mucosa of the stomach.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vmat2]
<Options>: A: vat2 (homo sapiens) (aka solute carrier family 18 member a2)
B: eaat2 (homo sapiens) (aka solute carrier family 1 member 2)
C: vglut2 (homo sapiens) (aka solute carrier family 17 member 6)
D: vmat1 (homo sapiens) (aka solute carrier family 18 member a1)
E: slc6a2 (homo sapiens) (aka so... | [A] |
<Instruct>: Given the context 'Catecholamines exhibit a 3-fold higher affinity, and histamine exhibits a 30-fold higher affinity, for VMAT2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vmat2]
<Options>: A: eaat2 (homo sapiens) (aka solute carrier family 1 member 2)
B: solute carrier family 18 (vesicular monoamine), member 2 (mus musculus) (aka solute carrier family 18 (vesicular monoamine), member 2)
C: vmat2 (rattus norvegicus) (aka solute carrier family 18 member a2)
D: vmat2 (homo sap... | [D] |
<Instruct>: Given the context 'Reserpine and ketanserin are slightly more potent inhibitors of VMAT2-mediated transport than of VMAT1-mediated transport, whereas tetrabenazine binds to and inhibits only VMAT2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the sel... | <Mentions>: [vmat2; vmat1]
<Options>: A: vmat-1 (rattus norvegicus) (aka solute carrier family 18 member a1)
B: vat1 (homo sapiens) (solute carrier family 18 member a1 (homo sapiens)) (aka solute carrier family 18 member a1)
C: vmat2 (homo sapiens) (aka solute carrier family 18 member a2)
D: vmat2 (rattus norvegicus) (... | [C; B] |
<Instruct>: Given the context 'Reserpine and ketanserin are slightly more potent inhibitors of VMAT2-mediated transport than of VMAT1-mediated transport, whereas tetrabenazine binds to and inhibits only VMAT2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the sel... | <Mentions>: [vmat2; vmat1]
<Options>: A: vat1 (homo sapiens) (solute carrier family 18 member a1 (homo sapiens)) (aka solute carrier family 18 member a1)
B: viaat (homo sapiens) (aka solute carrier family 32 member 1)
C: vmat2 (mus musculus) (aka solute carrier family 18 (vesicular monoamine), member 2)
D: slc6a2 (homo... | [F; A] |
<Instruct>: Given the context 'N-methyl-4-phenylpyridinium, phenylethylamine, amphetamine, and methylenedioxymethamphetamine are all more potent inhibitors of VMAT2 than of VMAT1, whereas fenfluramine is a more potent inhibitor of VMAT1-mediated monamine transport than of VMAT2-mediated monoamine transport.', select th... | <Mentions>: [vmat2; vmat1]
<Options>: A: eaat2 (homo sapiens) (aka solute carrier family 1 member 2)
B: slc6a2 (homo sapiens) (aka solute carrier family 6 member 2)
C: solute carrier family 18 (vesicular monoamine), member 1 (mus musculus) (aka solute carrier family 18 (vesicular monoamine), member 1)
D: vat1 (homo sap... | [G; D] |
<Instruct>: Given the context 'N-methyl-4-phenylpyridinium, phenylethylamine, amphetamine, and methylenedioxymethamphetamine are all more potent inhibitors of VMAT2 than of VMAT1, whereas fenfluramine is a more potent inhibitor of VMAT1-mediated monamine transport than of VMAT2-mediated monoamine transport.', select th... | <Mentions>: [vmat2; vmat1]
<Options>: A: viaat (homo sapiens) (aka solute carrier family 32 member 1)
B: vglut2 (homo sapiens) (aka solute carrier family 17 member 6)
C: vmat2 (rattus norvegicus) (aka solute carrier family 18 member a2)
D: vesicle amine transport 1 (homo sapiens) (aka vesicle amine transport 1)
E: eaat... | [J; I] |
<Instruct>: Given the context 'N-methyl-4-phenylpyridinium, phenylethylamine, amphetamine, and methylenedioxymethamphetamine are all more potent inhibitors of VMAT2 than of VMAT1, whereas fenfluramine is a more potent inhibitor of VMAT1-mediated monamine transport than of VMAT2-mediated monoamine transport.', select th... | <Mentions>: [vmat2; vmat1]
<Options>: A: viaat (homo sapiens) (aka solute carrier family 32 member 1)
B: vmat2 (homo sapiens) (aka solute carrier family 18 member a2)
C: vmat2 (mus musculus) (aka solute carrier family 18 (vesicular monoamine), member 2)
D: slc6a2 (homo sapiens) (aka solute carrier family 6 member 2)
E:... | [G; I] |
<Instruct>: Given the context 'The unique distributions of hVMAT1 and hVMAT2 provide new markers for multiple neuroendocrine lineages, and examination of their transport properties provides mechanistic insights into the pharmacology and physiology of amine storage in cardiovascular, endocrine, and central nervous syste... | <Mentions>: [hvmat1; hvmat2]
<Options>: A: solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 (mus musculus) (aka solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2)
B: maat1 (homo sapiens) (aka mitochondrial ribosomal protein l28)
C: vmat-... | [H; D] |
<Instruct>: Given the context 'The unique distributions of hVMAT1 and hVMAT2 provide new markers for multiple neuroendocrine lineages, and examination of their transport properties provides mechanistic insights into the pharmacology and physiology of amine storage in cardiovascular, endocrine, and central nervous syste... | <Mentions>: [hvmat1; hvmat2]
<Options>: A: amino acid transporter avt1j-like (glycine max) (aka amino acid transporter avt1j-like)
B: vmat1 (homo sapiens) (aka solute carrier family 18 member a1)
C: vstm2 (homo sapiens) (aka v-set and transmembrane domain containing 2a)
D: vat2 (homo sapiens) (aka solute carrier family... | [B; D] |
<Instruct>: Given the context 'The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c/ebpalpha; ob]
<Options>: A: cebpa (homo sapiens) (aka ccaat enhancer binding protein alpha)
B: ccaat enhancer binding protein beta (xenopus tropicalis) (aka ccaat enhancer binding protein beta)
C: c/ebp-beta (homo sapiens) (aka ccaat enhancer binding protein beta)
D: ob (homo sapiens) (leptin (homo sapie... | [A; D] |
<Instruct>: Given the context 'The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c/ebpalpha; ob]
<Options>: A: c/ebp-beta (homo sapiens) (aka ccaat enhancer binding protein beta)
B: c/ebp-alpha (homo sapiens) (aka ccaat enhancer binding protein alpha)
C: c/ebpbeta (xenopus tropicalis) (aka ccaat enhancer binding protein beta)
D: ob (homo sapiens) (leptin (homo sapiens)) (aka leptin)
E:... | [B; D] |
<Instruct>: Given the context 'The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c/ebpalpha; ob]
<Options>: A: c/ebpbeta (xenopus tropicalis) (aka ccaat enhancer binding protein beta)
B: obv (drosophila melanogaster) (aka centrosomin)
C: obp (drosophila melanogaster) (aka optix-binding protein)
D: ob (drosophila melanogaster) (aka oblique)
E: ob (homo sapiens) (leptin (homo sapiens)) (... | [I; E] |
<Instruct>: Given the context 'The ob gene product, leptin, apparently exclusively expressed in adipose tissue, is a signaling factor regulating body weight homeostasis and energy balance.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one fo... | <Mentions>: [ob; leptin]
<Options>: A: ob (homo sapiens) (leptin (homo sapiens)) (aka leptin)
B: lepr (homo sapiens) (leptin receptor (homo sapiens)) (aka leptin receptor)
C: ob (drosophila melanogaster) (aka oblique)
D: obv (drosophila melanogaster) (aka centrosomin)
E: obp (drosophila melanogaster) (aka optix-binding... | [A; A] |
<Instruct>: Given the context 'The ob gene product, leptin, apparently exclusively expressed in adipose tissue, is a signaling factor regulating body weight homeostasis and energy balance.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one fo... | <Mentions>: [ob; leptin]
<Options>: A: ob (drosophila melanogaster) (aka oblique)
B: leptin receptor (homo sapiens) (aka leptin receptor)
C: ob (oryctolagus cuniculus) (aka leptin)
D: leptin (oryctolagus cuniculus) (aka leptin)
E: ob (homo sapiens) (leptin (homo sapiens)) (aka leptin)
F: leptin, serum levels of (homo s... | [E; E] |
<Instruct>: Given the context 'ob gene expression is increased in obese rodents and regulated by feeding, insulin, and glucocorticoids, which supports the concept that ob gene expression is under hormonal control, which is expected for a key factor controlling body weight homeostasis and energy balance.', select the co... | <Mentions>: [ob]
<Options>: A: ob (homo sapiens) (leptin (homo sapiens)) (aka leptin)
B: obv (drosophila melanogaster) (aka centrosomin)
C: obf (homo sapiens) (aka izumo sperm-oocyte fusion 1)
D: ob1 (gallus gallus) (aka hop homeobox)
E: obp-1 (homo sapiens) (aka kinesin family member 22)
F: None of the above. | [A] |
<Instruct>: Given the context 'In humans, ob mRNA expression is increased in gross obesity; however, the effects of the above factors on human ob expression are unknown.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [ob]
<Options>: A: leptin (homo sapiens) (aka leptin)
B: ob (oryctolagus cuniculus) (aka leptin)
C: obf (homo sapiens) (aka izumo sperm-oocyte fusion 1)
D: obr (homo sapiens) (aka leptin receptor)
E: obp-1 (homo sapiens) (aka kinesin family member 22)
F: None of the above. | [A] |
<Instruct>: Given the context 'We describe the structure of the human ob gene and initial functional analysis of its promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ob]
<Options>: A: obr (homo sapiens) (aka leptin receptor)
B: ob (homo sapiens) (leptin (homo sapiens)) (aka leptin)
C: ob (oryctolagus cuniculus) (aka leptin)
D: ob1 (gallus gallus) (aka hop homeobox)
E: obp-1 (homo sapiens) (aka kinesin family member 22)
F: None of the above. | [B] |
<Instruct>: Given the context 'The human ob gene's three exons cover approximately 15 kb of genomic DNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ob]
<Options>: A: leptin (homo sapiens) (aka leptin)
B: ob (oryctolagus cuniculus) (aka leptin)
C: obp-1 (homo sapiens) (aka kinesin family member 22)
D: obv (drosophila melanogaster) (aka centrosomin)
E: obr (homo sapiens) (aka leptin receptor)
F: None of the above. | [A] |
<Instruct>: Given the context 'Only 217 bp of 5' sequence are required for basal adipose tissue-specific expression of the ob gene as well as enhanced expression by C/EBPalpha.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each menti... | <Mentions>: [ob; c/ebpalpha]
<Options>: A: c/ebp-beta (homo sapiens) (aka ccaat enhancer binding protein beta)
B: ob (oryctolagus cuniculus) (aka leptin)
C: leptin (homo sapiens) (aka leptin)
D: obp (drosophila melanogaster) (aka optix-binding protein)
E: ccaat enhancer binding protein alpha (homo sapiens) (aka ccaat e... | [C; E] |
<Instruct>: Given the context 'Only 217 bp of 5' sequence are required for basal adipose tissue-specific expression of the ob gene as well as enhanced expression by C/EBPalpha.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each menti... | <Mentions>: [ob; c/ebpalpha]
<Options>: A: ccaat enhancer binding protein beta (xenopus tropicalis) (aka ccaat enhancer binding protein beta)
B: leptin (homo sapiens) (aka leptin)
C: obp (drosophila melanogaster) (aka optix-binding protein)
D: obr (homo sapiens) (aka leptin receptor)
E: c/ebp (xenopus tropicalis) (aka ... | [B; I] |
<Instruct>: Given the context 'Only 217 bp of 5' sequence are required for basal adipose tissue-specific expression of the ob gene as well as enhanced expression by C/EBPalpha.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each menti... | <Mentions>: [ob; c/ebpalpha]
<Options>: A: c/ebp-beta (homo sapiens) (aka ccaat enhancer binding protein beta)
B: c/ebp-alpha (homo sapiens) (aka ccaat enhancer binding protein alpha)
C: ob1 (gallus gallus) (aka hop homeobox)
D: ob (oryctolagus cuniculus) (aka leptin)
E: obp (drosophila melanogaster) (aka optix-binding... | [H; B] |
<Instruct>: Given the context 'Mutation of the single C/EBPalpha site in this region abolished inducibility of the promoter by C/EBPalpha in cotransfection assays.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [c/ebpalpha]
<Options>: A: cebpa (homo sapiens) (aka ccaat enhancer binding protein alpha)
B: c/ebp (xenopus tropicalis) (aka ccaat enhancer binding protein alpha)
C: c/ebp-beta (homo sapiens) (aka ccaat enhancer binding protein beta)
D: ccaat enhancer binding protein beta (xenopus tropicalis) (aka ccaat en... | [A] |
<Instruct>: Given the context 'The gene structure will facilitate our analysis of ob mutations in human obesity, whereas knowledge of sequence elements and factors regulating ob gene expression should be of major importance in the prevention and treatment of obesity.', select the correct biomedical concept for each men... | <Mentions>: [ob]
<Options>: A: leptin (homo sapiens) (aka leptin)
B: obp (drosophila melanogaster) (aka optix-binding protein)
C: ob (oryctolagus cuniculus) (aka leptin)
D: ob1 (gallus gallus) (aka hop homeobox)
E: ob (drosophila melanogaster) (aka oblique)
F: None of the above. | [A] |
<Instruct>: Given the context 'Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ara70; androgen receptor]
<Options>: A: rpa70 (homo sapiens) (aka replication protein a1)
B: crsp70 (homo sapiens) (aka mediator complex subunit 26)
C: thra1 (homo sapiens) (aka nuclear receptor subfamily 1 group d member 1)
D: androgen receptor (homo sapiens) (aka androgen receptor)
E: ara70 (mus musculus... | [H; D] |
<Instruct>: Given the context 'Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ara70; androgen receptor]
<Options>: A: crsp70 (homo sapiens) (aka mediator complex subunit 26)
B: ara70 (homo sapiens) (aka nuclear receptor coactivator 4)
C: nr5a1 (homo sapiens) (aka nuclear receptor subfamily 5 group a member 1)
D: ara160 (homo sapiens) (aka tata element modulatory factor 1)
E: androge... | [B; G] |
<Instruct>: Given the context 'The androgen receptor (AR) is a member of the steroid receptor superfamily that plays an important role in male sexual differentiation and prostate cell proliferation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected optio... | <Mentions>: [androgen receptor; ar]
<Options>: A: androgen receptor (homo sapiens) (aka androgen receptor)
B: retinoid x receptor alpha (homo sapiens) (aka retinoid x receptor alpha)
C: ar1 (homo sapiens) (aka transcription factor 20)
D: ager1 (homo sapiens) (aka dolichyl-diphosphooligosaccharide--protein glycosyltrans... | [A; A] |
<Instruct>: Given the context 'The androgen receptor (AR) is a member of the steroid receptor superfamily that plays an important role in male sexual differentiation and prostate cell proliferation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected optio... | <Mentions>: [androgen receptor; ar]
<Options>: A: androgen receptor (rattus norvegicus) (aka androgen receptor)
B: ager (homo sapiens) (aka advanced glycosylation end-product specific receptor)
C: thra1 (homo sapiens) (aka nuclear receptor subfamily 1 group d member 1)
D: nr5a1 (homo sapiens) (aka nuclear receptor subf... | [I; I] |
<Instruct>: Given the context 'The androgen receptor (AR) is a member of the steroid receptor superfamily that plays an important role in male sexual differentiation and prostate cell proliferation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected optio... | <Mentions>: [androgen receptor; ar]
<Options>: A: androgen receptor (homo sapiens) (aka androgen receptor)
B: androgen receptor repeat instability region (homo sapiens) (aka androgen receptor repeat instability region)
C: ar1 (arabidopsis thaliana) (aka p450 reductase 1)
D: ar (drosophila melanogaster) (defective in th... | [A; A] |
<Instruct>: Given the context 'Mutations or abnormal expression of AR in prostate cancer can play a key role in the process that changes prostate cancer from androgen-dependent to an androgen-independent stage.', select the correct biomedical concept for each mention using the provided options. Answer by listing the se... | <Mentions>: [ar]
<Options>: A: ar (homo sapiens) (androgen receptor (homo sapiens)) (aka androgen receptor)
B: ager1 (homo sapiens) (aka dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit)
C: anr1 (arabidopsis thaliana) (aka agamous-like 44)
D: ager (homo sapiens) (aka advanced glycosy... | [A] |
<Instruct>: Given the context 'Using a yeast two-hybrid system, we were able to isolate a ligand-dependent AR-associated protein (ARA70), which functions as an activator to enhance AR transcriptional activity 10-fold in the presence of 10(-10)', select the correct biomedical concept for each mention using the provided ... | <Mentions>: [ligand-dependent ar-associated protein; ara70; ar]
<Options>: A: ar1 (homo sapiens) (aka transcription factor 20)
B: ra70 (homo sapiens) (aka src kinase associated phosphoprotein 2)
C: rpa70 (homo sapiens) (aka replication protein a1)
D: ar (rattus norvegicus) (androgen receptor (rattus norvegicus)) (aka a... | [I; I; L] |
<Instruct>: Given the context 'Using a yeast two-hybrid system, we were able to isolate a ligand-dependent AR-associated protein (ARA70), which functions as an activator to enhance AR transcriptional activity 10-fold in the presence of 10(-10)', select the correct biomedical concept for each mention using the provided ... | <Mentions>: [ligand-dependent ar-associated protein; ara70; ar]
<Options>: A: ara70 (homo sapiens) (aka nuclear receptor coactivator 4)
B: ar1 (arabidopsis thaliana) (aka p450 reductase 1)
C: transformation/transcription domain associated protein (homo sapiens) (aka transformation/transcription domain associated protei... | [A; A; M] |
<Instruct>: Given the context 'Using a yeast two-hybrid system, we were able to isolate a ligand-dependent AR-associated protein (ARA70), which functions as an activator to enhance AR transcriptional activity 10-fold in the presence of 10(-10)', select the correct biomedical concept for each mention using the provided ... | <Mentions>: [ligand-dependent ar-associated protein; ara70; ar]
<Options>: A: anr1 (arabidopsis thaliana) (aka agamous-like 44)
B: ra70 (homo sapiens) (aka src kinase associated phosphoprotein 2)
C: crsp70 (homo sapiens) (aka mediator complex subunit 26)
D: angiotensin ii receptor associated protein (homo sapiens) (aka... | [I; I; K] |
<Instruct>: Given the context 'Our data further indicated that ARA70 Will only slightly induce the transcriptional activity of other steroid receptors such as estrogen receptor, glucocorticoid receptor, and progesterone receptor in DU145 cells.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [ara70; glucocorticoid receptor; progesterone receptor]
<Options>: A: nr1c1 (homo sapiens) (aka peroxisome proliferator activated receptor alpha)
B: nr3c4 (homo sapiens) (aka androgen receptor)
C: ara70 (xenopus tropicalis) (aka nuclear receptor coactivator 4)
D: ra70 (homo sapiens) (aka src kinase associat... | [E; F; J] |
<Instruct>: Given the context 'Our data further indicated that ARA70 Will only slightly induce the transcriptional activity of other steroid receptors such as estrogen receptor, glucocorticoid receptor, and progesterone receptor in DU145 cells.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [ara70; glucocorticoid receptor; progesterone receptor]
<Options>: A: pgr (homo sapiens) (aka progesterone receptor)
B: ara70 (xenopus laevis) (nuclear receptor coactivator 4 s homeolog (xenopus laevis)) (aka nuclear receptor coactivator 4 s homeolog)
C: nr1c1 (homo sapiens) (aka peroxisome proliferator act... | [E; M; A] |
<Instruct>: Given the context 'Our data further indicated that ARA70 Will only slightly induce the transcriptional activity of other steroid receptors such as estrogen receptor, glucocorticoid receptor, and progesterone receptor in DU145 cells.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [ara70; glucocorticoid receptor; progesterone receptor]
<Options>: A: pgr (xenopus laevis) (progesterone receptor s homeolog (xenopus laevis)) (aka progesterone receptor s homeolog)
B: rpa70 (xenopus laevis) (replication protein a1 s homeolog (xenopus laevis)) (aka replication protein a1 s homeolog)
C: prog... | [I; H; O] |
<Instruct>: Given the context 'Together, these data suggest that AR may need a specific coactivator(s) such as ARA70 for optimal androgen activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ar; ara70]
<Options>: A: rpa70 (homo sapiens) (aka replication protein a1)
B: rpa70 (xenopus laevis) (replication protein a1 s homeolog (xenopus laevis)) (aka replication protein a1 s homeolog)
C: ager1 (homo sapiens) (aka dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit... | [F; E] |
<Instruct>: Given the context 'Together, these data suggest that AR may need a specific coactivator(s) such as ARA70 for optimal androgen activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ar; ara70]
<Options>: A: anr1 (arabidopsis thaliana) (aka agamous-like 44)
B: ar (homo sapiens) (androgen receptor (homo sapiens)) (aka androgen receptor)
C: arc100 (homo sapiens) (aka mediator complex subunit 24)
D: ager (homo sapiens) (aka advanced glycosylation end-product specific receptor)
E: ara70 (m... | [B; I] |
<Instruct>: Given the context 'Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [evi1]
<Options>: A: evi3 (homo sapiens) (aka zinc finger protein 521)
B: evi-1 (homo sapiens) (aka runx family transcription factor 1)
C: evi-1 (xenopus tropicalis) (mds1 and evi1 complex locus (xenopus tropicalis)) (aka mds1 and evi1 complex locus)
D: evi5 (homo sapiens) (aka ecotropic viral integration s... | [E] |
<Instruct>: Given the context 'The EVI1 gene, located at chromosome band 3q26, is overexpressed in some myeloid leukemia patients with breakpoints either 5' of the gene in the t(3;3)(q21;q26) or 3' of the gene in the inv(3)(q21q26).', select the correct biomedical concept for each mention using the provided options. An... | <Mentions>: [evi1]
<Options>: A: evi3 (homo sapiens) (aka zinc finger protein 521)
B: mds1-evi1 (homo sapiens) (aka mds1 and evi1 complex locus)
C: eve-1 (homo sapiens) (aka sh3 domain containing 19)
D: evi-1 (homo sapiens) (aka runx family transcription factor 1)
E: evi (homo sapiens) (aka wnt ligand secretion mediato... | [B] |
<Instruct>: Given the context 'EVI1 is also expressed as part of a fusion transcript with the transcription factor AML1 in the t(3;21)(q26;q22), associated with myeloid leukemia.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [evi1; aml1]
<Options>: A: aml2 (homo sapiens) (aka runx family transcription factor 3)
B: af1 (homo sapiens) (aka ephrin a5)
C: cbf-1 (homo sapiens) (aka recombination signal binding protein for immunoglobulin kappa j region)
D: evi1 (homo sapiens) (aka mds1 and evi1 complex locus)
E: eve-1 (homo sapiens) ... | [D; G] |
<Instruct>: Given the context 'EVI1 is also expressed as part of a fusion transcript with the transcription factor AML1 in the t(3;21)(q26;q22), associated with myeloid leukemia.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [evi1; aml1]
<Options>: A: evi5 (homo sapiens) (aka ecotropic viral integration site 5)
B: aml1 (homo sapiens) (aka runx family transcription factor 1)
C: cbf-1 (homo sapiens) (aka recombination signal binding protein for immunoglobulin kappa j region)
D: aml3 (homo sapiens) (aka runx family transcription f... | [H; B] |
<Instruct>: Given the context 'In cells with t(3;21), additional fusion transcripts are AML1-MDS1 and AML1-MDS1-EVI1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [aml1; evi1]
<Options>: A: evi (homo sapiens) (aka wnt ligand secretion mediator)
B: ev1 (homo sapiens) (aka transmembrane channel like 6)
C: aml-1 (xenopus tropicalis) (aka runx family transcription factor 1)
D: runx family transcription factor 1 (homo sapiens) (aka runx family transcription factor 1)
E: a... | [D; G] |
<Instruct>: Given the context 'In cells with t(3;21), additional fusion transcripts are AML1-MDS1 and AML1-MDS1-EVI1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [aml1; evi1]
<Options>: A: ev1 (homo sapiens) (aka transmembrane channel like 6)
B: evi5 (homo sapiens) (aka ecotropic viral integration site 5)
C: mds1-evi1 (homo sapiens) (aka mds1 and evi1 complex locus)
D: cbfa1 (homo sapiens) (aka runx family transcription factor 2)
E: runx family transcription factor ... | [E; C] |
<Instruct>: Given the context 'MDS1 is located at 3q26 170-400 kb upstream (telomeric) of EVI1 in the chromosomal region in which some of the breakpoints 5' of EVI1 have been mapped.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each... | <Mentions>: [evi1]
<Options>: A: eve-1 (homo sapiens) (aka sh3 domain containing 19)
B: evi-1 (xenopus tropicalis) (mds1 and evi1 complex locus (xenopus tropicalis)) (aka mds1 and evi1 complex locus)
C: evi3 (homo sapiens) (aka zinc finger protein 521)
D: mds1-evi1 (homo sapiens) (aka mds1 and evi1 complex locus)
E: ev... | [D] |
<Instruct>: Given the context 'MDS1 has been identified as a single gene as well as a previously unreported exon(s) of EVI1 We have analyzed the relationship between MDS1 and EVI1 to determine whether they are two separate genes.', select the correct biomedical concept for each mention using the provided options. Answe... | <Mentions>: [evi1]
<Options>: A: evi3 (homo sapiens) (aka zinc finger protein 521)
B: evi (homo sapiens) (aka wnt ligand secretion mediator)
C: mds1-evi1 (homo sapiens) (aka mds1 and evi1 complex locus)
D: evi-1 (xenopus tropicalis) (mds1 and evi1 complex locus (xenopus tropicalis)) (aka mds1 and evi1 complex locus)
E:... | [C] |
<Instruct>: Given the context 'In this report, we present evidence indicating that MDS1 exists in normal tissues both as a unique transcript and as a normal fusion transcript with EVI1, with an additional 188 codons at the 5' end of the previously reported EVI1 open reading frame.', select the correct biomedical concep... | <Mentions>: [evi1]
<Options>: A: eve-1 (homo sapiens) (aka sh3 domain containing 19)
B: mds1-evi1 (homo sapiens) (aka mds1 and evi1 complex locus)
C: evi5 (homo sapiens) (aka ecotropic viral integration site 5)
D: evin1 (homo sapiens) (aka transmembrane channel like 6)
E: evi-1 (xenopus tropicalis) (mds1 and evi1 compl... | [B] |
<Instruct>: Given the context 'This additional region has about 40% homology at the amino acid level with the PR domain of the retinoblastoma-interacting zinc-finger protein RIZ.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [retinoblastoma-interacting zinc-finger protein riz]
<Options>: A: riz (xenopus tropicalis) (aka pr domain containing 2, with znf domain)
B: cdkn1a interacting zinc finger protein 1 (homo sapiens) (aka cdkn1a interacting zinc finger protein 1)
C: riz2 (homo sapiens) (aka pr/set domain 2)
D: irz (homo sapien... | [C] |
<Instruct>: Given the context 'These results are important in view of the fact that EVI1 and MDS1 are involved in leukemia associated with chromosomal translocation breakpoints in the region between these genes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [evi1]
<Options>: A: evi-1 (xenopus tropicalis) (mds1 and evi1 complex locus (xenopus tropicalis)) (aka mds1 and evi1 complex locus)
B: eve-1 (homo sapiens) (aka sh3 domain containing 19)
C: evin1 (homo sapiens) (aka transmembrane channel like 6)
D: mds1-evi1 (homo sapiens) (aka mds1 and evi1 complex locus)... | [D] |
<Instruct>: Given the context 'These results are important in view of the fact that EVI1 and MDS1 are involved in leukemia associated with chromosomal translocation breakpoints in the region between these genes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [evi1]
<Options>: A: evi-1 (homo sapiens) (aka runx family transcription factor 1)
B: eve-1 (homo sapiens) (aka sh3 domain containing 19)
C: evi-1 (xenopus tropicalis) (mds1 and evi1 complex locus (xenopus tropicalis)) (aka mds1 and evi1 complex locus)
D: evin1 (homo sapiens) (aka transmembrane channel like... | [E] |
<Instruct>: Given the context 'MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mdc9]
<Options>: A: mda-9 (homo sapiens) (aka syndecan binding protein)
B: adam metallopeptidase with thrombospondin type 1 motif 9 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 9)
C: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans... | [D] |
<Instruct>: Given the context 'We have cloned and sequenced the mouse and human homologue of a widely expressed cellular disintegrin, which we have termed MDC9 (for metalloprotease/disintegrin/cysteine-rich protein 9).', select the correct biomedical concept for each mention using the provided options. Answer by listin... | <Mentions>: [mdc9; metalloprotease/disintegrin/cysteine-rich protein 9]
<Options>: A: mdc9 (mus musculus) (aka adam metallopeptidase domain 9)
B: mdc-3 (homo sapiens) (aka adam metallopeptidase domain 23)
C: disintegrin and metalloproteinase domain-containing protein 9 (xenopus tropicalis) (aka disintegrin and metallop... | [D; D] |
<Instruct>: Given the context 'We have cloned and sequenced the mouse and human homologue of a widely expressed cellular disintegrin, which we have termed MDC9 (for metalloprotease/disintegrin/cysteine-rich protein 9).', select the correct biomedical concept for each mention using the provided options. Answer by listin... | <Mentions>: [mdc9; metalloprotease/disintegrin/cysteine-rich protein 9]
<Options>: A: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain-containing protein 10 homolog)
B: mdc-l (homo sapiens) (aka adam metallopeptidase domain 28)... | [C; C] |
<Instruct>: Given the context 'MDC9 contains several distinct protein domains: a signal sequence is followed by a prodomain and a domain with sequence similarity to snake venom metalloproteases, a disintegrin domain, a cysteine-rich region, an EGF repeat, a membrane anchor, and a cytoplasmic tail.', select the correct ... | <Mentions>: [mdc9]
<Options>: A: mdc-3 (homo sapiens) (aka adam metallopeptidase domain 23)
B: adam metallopeptidase domain 9 (homo sapiens) (aka adam metallopeptidase domain 9)
C: mdc9 (mus musculus) (aka adam metallopeptidase domain 9)
D: mda-9 (homo sapiens) (aka syndecan binding protein)
E: mdc-l (homo sapiens) (ak... | [B] |
<Instruct>: Given the context 'The cytoplasmic tail of MDC9 has two proline-rich sequences which can bind the SH3 domain of Src, and may therefore function as SH3 ligand domains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [mdc9; src]
<Options>: A: c-src (homo sapiens) (aka src proto-oncogene, non-receptor tyrosine kinase)
B: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain-containing protein 10 homolog)
C: adam metallopeptidase domai... | [C; A] |
<Instruct>: Given the context 'The cytoplasmic tail of MDC9 has two proline-rich sequences which can bind the SH3 domain of Src, and may therefore function as SH3 ligand domains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [mdc9; src]
<Options>: A: src3 (homo sapiens) (aka nuclear receptor coactivator 3)
B: mdc9 (homo sapiens) (aka adam metallopeptidase domain 9)
C: src1 (homo sapiens) (aka nuclear receptor coactivator 1)
D: c-src2 (homo sapiens) (aka fgr proto-oncogene, src family tyrosine kinase)
E: disintegrin and metallop... | [B; I] |
<Instruct>: Given the context 'The cytoplasmic tail of MDC9 has two proline-rich sequences which can bind the SH3 domain of Src, and may therefore function as SH3 ligand domains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [mdc9; src]
<Options>: A: mdc-l (homo sapiens) (aka adam metallopeptidase domain 28)
B: src3 (homo sapiens) (aka nuclear receptor coactivator 3)
C: c-src (sus scrofa) (aka src proto-oncogene, non-receptor tyrosine kinase)
D: src1 (homo sapiens) (aka nuclear receptor coactivator 1)
E: mdc9 (mus musculus) (ak... | [J; H] |
<Instruct>: Given the context 'Western blot analysis shows that MDC9 is an approximately 84-kD glycoprotein in all mouse tissues examined, and in NIH 3T3 fibroblast and C2C12 myoblast mouse cell lines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [mdc9]
<Options>: A: adam metallopeptidase domain 9 (homo sapiens) (aka adam metallopeptidase domain 9)
B: adam metallopeptidase with thrombospondin type 1 motif 9 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 9)
C: mdc-3 (homo sapiens) (aka adam metallopeptidase domain 23)
D: m... | [A] |
<Instruct>: Given the context 'MDC9 can be both cell surface biotinylated and 125I-labeled in NIH 3T3 mouse fibroblasts, indicating that the protein is present on the plasma membrane.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [mdc9]
<Options>: A: mdc9 (mus musculus) (aka adam metallopeptidase domain 9)
B: mda-9 (homo sapiens) (aka syndecan binding protein)
C: adam metallopeptidase with thrombospondin type 1 motif 9 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 9)
D: adam9 (homo sapiens) (aka adam met... | [D] |
<Instruct>: Given the context 'Expression of MDC9 in COS-7 cells yields an 84-kD protein, and immunofluorescence analysis of COS-7 cells expressing MDC9 shows a staining pattern that is consistent with a plasma membrane localization.', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [mdc9]
<Options>: A: adam metallopeptidase domain 9 (homo sapiens) (aka adam metallopeptidase domain 9)
B: mdc15 (homo sapiens) (aka adam metallopeptidase domain 15)
C: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase doma... | [A] |
<Instruct>: Given the context 'The apparent molecular mass of 84 kD suggests that MDC9 contains a membrane-anchored metalloprotease and disintegrin domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semi... | <Mentions>: [mdc9]
<Options>: A: mdc-3 (homo sapiens) (aka adam metallopeptidase domain 23)
B: mdc15 (homo sapiens) (aka adam metallopeptidase domain 15)
C: mdc9 (mus musculus) (aka adam metallopeptidase domain 9)
D: mda-9 (homo sapiens) (aka syndecan binding protein)
E: adam metallopeptidase domain 9 (homo sapiens) (a... | [E] |
<Instruct>: Given the context 'We propose that MDC9 might function as a membrane-anchored integrin ligand or metalloprotease, or that MDC9 may combine both activities in one protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each... | <Mentions>: [mdc9]
<Options>: A: mda-9 (homo sapiens) (aka syndecan binding protein)
B: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain-containing protein 10 homolog)
C: adam9 (homo sapiens) (aka adam metallopeptidase domain 9... | [C] |
<Instruct>: Given the context 'A GLRA1 null mutation in recessive hyperekplexia challenges the functional role of glycine receptors.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [glra1]
<Options>: A: glra1.l (xenopus laevis) (aka glycine receptor alpha 1 l homeolog)
B: glra4 (homo sapiens) (aka glycine receptor alpha 4 (pseudogene))
C: glra1 (homo sapiens) (aka glycine receptor alpha 1)
D: glra1 (mus musculus) (aka glycine receptor, alpha 1 subunit)
E: glutamate receptor 1.1-like (... | [C] |
<Instruct>: Given the context 'Dominant missense mutations in the human glycine receptor (GlyR) alpha 1 subunit gene (GLRA1) give rise to hereditary hyperekplexia.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [glycine receptor (glyr) alpha 1; glra1]
<Options>: A: glr (homo sapiens) (aka glycine receptor alpha 2)
B: glr1.1 (arabidopsis thaliana) (aka glutamate receptor 1.1)
C: glutamate receptor 1.1-like (glycine max) (aka glutamate receptor 1.1-like)
D: glycine receptor alpha 1 (homo sapiens) (aka glycine recept... | [D; D] |
<Instruct>: Given the context 'Dominant missense mutations in the human glycine receptor (GlyR) alpha 1 subunit gene (GLRA1) give rise to hereditary hyperekplexia.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [glycine receptor (glyr) alpha 1; glra1]
<Options>: A: glutamate receptor 1.1-like (glycine max) (aka glutamate receptor 1.1-like)
B: glra1.l (xenopus laevis) (aka glycine receptor alpha 1 l homeolog)
C: glycine receptor alpha 1 (xenopus tropicalis) (aka glycine receptor alpha 1)
D: glra4 (homo sapiens) (ak... | [I; I] |
<Instruct>: Given the context 'Dominant missense mutations in the human glycine receptor (GlyR) alpha 1 subunit gene (GLRA1) give rise to hereditary hyperekplexia.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [glycine receptor (glyr) alpha 1; glra1]
<Options>: A: glycine receptor alpha 1 (xenopus tropicalis) (aka glycine receptor alpha 1)
B: glra1.l (xenopus laevis) (aka glycine receptor alpha 1 l homeolog)
C: glutamate receptor 1.1-like (glycine max) (aka glutamate receptor 1.1-like)
D: glycine receptor, alpha ... | [I; I] |
<Instruct>: Given the context 'In a recessive case of hyperekplexia, we found a deletion of exons 1-6 of the GLRA1 gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [glra1]
<Options>: A: glutamate receptor 1.1-like (glycine max) (aka glutamate receptor 1.1-like)
B: glra1 (homo sapiens) (aka glycine receptor alpha 1)
C: glra4 (homo sapiens) (aka glycine receptor alpha 4 (pseudogene))
D: glra1 (rattus norvegicus) (aka glycine receptor, alpha 1)
E: glr1.1 (arabidopsis tha... | [B] |
<Instruct>: Given the context 'Born to consanguineous parents, the affected child is homozygous for this GLRA1(null) allele consistent with a complete loss of gene function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [glra1]
<Options>: A: glra4 (homo sapiens) (aka glycine receptor alpha 4 (pseudogene))
B: glra1.l (xenopus laevis) (aka glycine receptor alpha 1 l homeolog)
C: glra2 (homo sapiens) (aka glycine receptor alpha 2)
D: glutamate receptor 1.1-like (glycine max) (aka glutamate receptor 1.1-like)
E: glra1 (homo sa... | [E] |
<Instruct>: Given the context 'This case demonstrates that, in contrast to the lethal effect of a null allele in the recessive mouse mutant oscillator (Glra1 spd-ot), the loss of the GlyR alpha 1 subunit is effectively compensated in man.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [glra1; spd; ot; glyr alpha 1]
<Options>: A: otop3 (oryctolagus cuniculus) (aka otopetrin 3)
B: glra1 (homo sapiens) (aka glycine receptor alpha 1)
C: spdsy (homo sapiens) (aka spermidine synthase)
D: spds (drosophila melanogaster) (aka spermidine synthase)
E: otol1 (oryctolagus cuniculus) (aka otolin 1)
F:... | [B; B; B; B] |
<Instruct>: Given the context 'This case demonstrates that, in contrast to the lethal effect of a null allele in the recessive mouse mutant oscillator (Glra1 spd-ot), the loss of the GlyR alpha 1 subunit is effectively compensated in man.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [glra1; spd; ot; glyr alpha 1]
<Options>: A: glra1 (mus musculus) (aka glycine receptor, alpha 1 subunit)
B: spdsy (homo sapiens) (aka spermidine synthase)
C: glra4 (homo sapiens) (aka glycine receptor alpha 4 (pseudogene))
D: spdyc (homo sapiens) (aka speedy/ringo cell cycle regulator family member c)
E: s... | [F; F; F; F] |
<Instruct>: Given the context 'This case demonstrates that, in contrast to the lethal effect of a null allele in the recessive mouse mutant oscillator (Glra1 spd-ot), the loss of the GlyR alpha 1 subunit is effectively compensated in man.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [glra1; spd; ot; glyr alpha 1]
<Options>: A: alpha1aar (homo sapiens) (aka adrenoceptor alpha 1a)
B: spdl1 (homo sapiens) (aka spindle apparatus coiled-coil protein 1)
C: guanine nucleotide-binding protein alpha-1 subunit (glycine max) (aka guanine nucleotide-binding protein alpha-1 subunit)
D: glra4 (homo ... | [S; S; S; S] |
<Instruct>: Given the context 'This case demonstrates that, in contrast to the lethal effect of a null allele in the recessive mouse mutant oscillator (Glra1 spd-ot), the loss of the GlyR alpha 1 subunit is effectively compensated in man.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [glra1; spd; ot; glyr alpha 1]
<Options>: A: otr (drosophila melanogaster) (aka octopamine-tyramine receptor)
B: glra1 (homo sapiens) (aka glycine receptor alpha 1)
C: spdl1 (homo sapiens) (aka spindle apparatus coiled-coil protein 1)
D: glra1.l (xenopus laevis) (aka glycine receptor alpha 1 l homeolog)
E: ... | [B; B; B; B] |
<Instruct>: Given the context 'This case demonstrates that, in contrast to the lethal effect of a null allele in the recessive mouse mutant oscillator (Glra1 spd-ot), the loss of the GlyR alpha 1 subunit is effectively compensated in man.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [glra1; spd; ot; glyr alpha 1]
<Options>: A: ot (homo sapiens) (aka oxytocin/neurophysin i prepropeptide)
B: glyr-a1 (xenopus laevis) (glycine receptor alpha 1 s homeolog (xenopus laevis)) (aka glycine receptor alpha 1 s homeolog)
C: spd (homo sapiens) (aka homeobox d13)
D: glr1.1 (arabidopsis thaliana) (ak... | [I; I; I; I] |
<Instruct>: Given the context 'Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [apo-2 ligand]
<Options>: A: cd40 ligand (homo sapiens) (aka cd40 ligand)
B: apo3l (homo sapiens) (aka tnf superfamily member 12)
C: apol2 (homo sapiens) (aka apolipoprotein l2)
D: fas ligand (homo sapiens) (aka fas ligand)
E: apo-2l (homo sapiens) (aka tnf superfamily member 10)
F: None of the above. | [E] |
<Instruct>: Given the context 'We have isolated a new member of this family, designated Apo-2 ligand (Apo-2L), via an expressed sequence tag.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [apo-2 ligand; apo-2l]
<Options>: A: apo-2l (homo sapiens) (aka tnf superfamily member 10)
B: apo3l (homo sapiens) (aka tnf superfamily member 12)
C: fas ligand (homo sapiens) (aka fas ligand)
D: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
E: apol2 (homo sapiens) (aka apolipoprotein l2)
F:... | [A; A] |
<Instruct>: Given the context 'We have isolated a new member of this family, designated Apo-2 ligand (Apo-2L), via an expressed sequence tag.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [apo-2 ligand; apo-2l]
<Options>: A: fas ligand (homo sapiens) (aka fas ligand)
B: apol2 (homo sapiens) (aka apolipoprotein l2)
C: trail (homo sapiens) (aka tnf superfamily member 10)
D: apo3l (homo sapiens) (aka tnf superfamily member 12)
E: cd95-l (homo sapiens) (aka fas ligand)
F: apo-l (homo sapiens) (a... | [C; C] |
<Instruct>: Given the context 'Apo-2L is a 281-amino acid protein, related most closely to Fas/Apo-1 ligand.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [apo-2l; fas; apo-1 ligand]
<Options>: A: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
B: apol1 (homo sapiens) (aka apolipoprotein l1)
C: apo3l (homo sapiens) (aka tnf superfamily member 12)
D: apo-2l (homo sapiens) (aka tnf superfamily member 10)
E: fasps (homo sapiens) (aka period circadi... | [G; H; H] |
<Instruct>: Given the context 'Apo-2L is a 281-amino acid protein, related most closely to Fas/Apo-1 ligand.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [apo-2l; fas; apo-1 ligand]
<Options>: A: fas (homo sapiens) (fas cell surface death receptor (homo sapiens)) (aka fas cell surface death receptor)
B: fas (gallus gallus) (aka fas cell surface death receptor)
C: apo3l (homo sapiens) (aka tnf superfamily member 12)
D: cd95l (homo sapiens) (aka fas ligand)
E:... | [J; A; A] |
<Instruct>: Given the context 'Apo-2L is a 281-amino acid protein, related most closely to Fas/Apo-1 ligand.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [apo-2l; fas; apo-1 ligand]
<Options>: A: fasn (homo sapiens) (aka fatty acid synthase)
B: apo-2l (homo sapiens) (aka tnf superfamily member 10)
C: apo3l (homo sapiens) (aka tnf superfamily member 12)
D: apo2l (homo sapiens) (aka tnf superfamily member 10)
E: apo1 (homo sapiens) (aka apolipoprotein b mrna e... | [D; H; H] |
<Instruct>: Given the context 'Transfected Apo-2L is expressed at the cell surface with its C terminus exposed, indicating a type II transmembrane protein topology.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [apo-2l]
<Options>: A: apol2 (homo sapiens) (aka apolipoprotein l2)
B: apo-2l (homo sapiens) (aka tnf superfamily member 10)
C: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
D: apo3l (homo sapiens) (aka tnf superfamily member 12)
E: cd95-l (homo sapiens) (aka fas ligand)
F: None of the above... | [B] |
<Instruct>: Given the context 'Like Fas/Apo-1 ligand and TNF, the C-terminal extracellular region of Apo-2L (amino acids 114-281) exhibits a homotrimeric subunit structure.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [fas; apo-1 ligand; apo-2l]
<Options>: A: fas ligand (homo sapiens) (aka fas ligand)
B: tall2 (homo sapiens) (aka tnf superfamily member 13)
C: fast (homo sapiens) (fas activated serine/threonine kinase (homo sapiens)) (aka fas activated serine/threonine kinase)
D: fas (gallus gallus) (aka fas cell surface ... | [L; L; K] |
<Instruct>: Given the context 'Like Fas/Apo-1 ligand and TNF, the C-terminal extracellular region of Apo-2L (amino acids 114-281) exhibits a homotrimeric subunit structure.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [fas; apo-1 ligand; apo-2l]
<Options>: A: fast (homo sapiens) (fas activated serine/threonine kinase (homo sapiens)) (aka fas activated serine/threonine kinase)
B: apol1 (homo sapiens) (aka apolipoprotein l1)
C: fasps (homo sapiens) (aka period circadian regulator 2)
D: cd40 ligand (homo sapiens) (aka cd40 ... | [F; F; H] |
<Instruct>: Given the context 'Like Fas/Apo-1 ligand and TNF, the C-terminal extracellular region of Apo-2L (amino acids 114-281) exhibits a homotrimeric subunit structure.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [fas; apo-1 ligand; apo-2l]
<Options>: A: fas ligand (homo sapiens) (aka fas ligand)
B: apo1 (homo sapiens) (aka apolipoprotein b mrna editing enzyme catalytic subunit 1)
C: fast (homo sapiens) (fas activated serine/threonine kinase (homo sapiens)) (aka fas activated serine/threonine kinase)
D: apo-2l (homo... | [J; J; D] |
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