instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Isolation of a novel human cDNA (rhoHP1) homologous to rho genes.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rhohp1]
<Options>: A: rhoh9 (homo sapiens) (aka ras homolog family member c)
B: rhoh (homo sapiens) (aka ras homolog family member h)
C: rho (drosophila melanogaster) (rho1 (drosophila melanogaster)) (aka rho1)
D: rhohp1 (homo sapiens) (aka ras homolog family member d)
E: rho family gtpase 1 (homo sapiens)... | [D] |
<Instruct>: Given the context 'In view of its degree of homology to members of the Rho family of molecules (50-54% identical amino acids, 60-63% identical nucleotides within the coding region), the predicted product was designated RhoHP1(Rho-related protein HP1).', select the correct biomedical concept for each mention... | <Mentions>: [rhohp1; rho-related protein hp1]
<Options>: A: rhoh9 (homo sapiens) (aka ras homolog family member c)
B: rho family gtpase 3 (homo sapiens) (aka rho family gtpase 3)
C: chp/wrch rho-like protein homolog (caenorhabditis elegans) (aka chp/wrch rho-like protein homolog)
D: rhohp1 (homo sapiens) (aka ras homol... | [D; D] |
<Instruct>: Given the context 'In view of its degree of homology to members of the Rho family of molecules (50-54% identical amino acids, 60-63% identical nucleotides within the coding region), the predicted product was designated RhoHP1(Rho-related protein HP1).', select the correct biomedical concept for each mention... | <Mentions>: [rhohp1; rho-related protein hp1]
<Options>: A: rho family gtpase 3 (homo sapiens) (aka rho family gtpase 3)
B: rho family gtpase 1 (homo sapiens) (aka rho family gtpase 1)
C: chp/wrch rho-like protein homolog (caenorhabditis elegans) (aka chp/wrch rho-like protein homolog)
D: rhohp1 (homo sapiens) (aka ras... | [D; D] |
<Instruct>: Given the context 'I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [i kappa b epsilon; rela; crel; nf-kappa b]
<Options>: A: v-rel avian reticuloendotheliosis viral oncogene homolog (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog)
B: cation transport regulator-like protein 2-like (glycine max) (aka cation transport regulator-like protein ... | [J; C; R; K] |
<Instruct>: Given the context 'I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [i kappa b epsilon; rela; crel; nf-kappa b]
<Options>: A: probable catabolite repression protein crec (glycine max) (aka probable catabolite repression protein crec)
B: rela proto-oncogene, nf-kb subunit (xenopus tropicalis) (aka rela proto-oncogene, nf-kb subunit)
C: creld1 (oryctolagus cuniculus) (aka cre... | [H; F; R; Q] |
<Instruct>: Given the context 'I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [i kappa b epsilon; rela; crel; nf-kappa b]
<Options>: A: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
B: nfkbie (homo sapiens) (aka nfkb inhibitor epsilon)
C: crrl (homo sapiens) (aka dickkopf wnt signaling pathway inhibitor 3)
D: crep (homo sapiens) (aka prote... | [S; P; U; F] |
<Instruct>: Given the context 'I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [i kappa b epsilon; rela; crel; nf-kappa b]
<Options>: A: nf-kappa-b1 (homo sapiens) (aka nuclear factor kappa b subunit 1)
B: probable catabolite repression protein crec (glycine max) (aka probable catabolite repression protein crec)
C: ikb-epsilon (xenopus tropicalis) (aka nuclear factor of kappa light po... | [M; G; S; A] |
<Instruct>: Given the context 'We have isolated a human cDNA which encodes a novel I kappa B family member using a yeast two-hybrid screen for proteins able to interact with the p52 subunit of the transcription factor NF-kappa B.', select the correct biomedical concept for each mention using the provided options. Answe... | <Mentions>: [nf-kappa b]
<Options>: A: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
B: nf-kappabeta (homo sapiens) (aka nuclear factor kappa b subunit 1)
C: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
D: relb proto-oncogene, nf-kb ... | [B] |
<Instruct>: Given the context 'The protein is found in many cell types and its expression is up-regulated following NF-kappa B activation and during myelopoiesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [nf-kappa b]
<Options>: A: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
B: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
C: nuclear factor kappa b subunit 1 (homo sapiens) (aka nuclear factor kappa b subunit 1)
D: nfk... | [C] |
<Instruct>: Given the context 'Consistent with its proposed role as an I kappa B molecule, I kappa B-epsilon is able to inhibit NF-kappa B-directed transactivation via cytoplasmic retention of rel proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [i kappa b-epsilon; nf-kappa b]
<Options>: A: nfkb inhibitor epsilon (homo sapiens) (aka nfkb inhibitor epsilon)
B: nuclear factor kappa b subunit 1 (homo sapiens) (aka nuclear factor kappa b subunit 1)
C: i-kappa-b-zeta (homo sapiens) (aka nfkb inhibitor zeta)
D: relb proto-oncogene, nf-kb subunit (homo sa... | [I; B] |
<Instruct>: Given the context 'Consistent with its proposed role as an I kappa B molecule, I kappa B-epsilon is able to inhibit NF-kappa B-directed transactivation via cytoplasmic retention of rel proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [i kappa b-epsilon; nf-kappa b]
<Options>: A: nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, epsilon (xenopus tropicalis) (aka nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, epsilon)
B: nfkbib (homo sapiens) (aka nfkb inhibitor beta)
C: nuclear f... | [E; D] |
<Instruct>: Given the context 'I kappa B-epsilon translation initiates from an internal ATG codon to give rise to a protein of 45 kDa, which exists as multiple phosphorylated isoforms in resting cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [i kappa b-epsilon]
<Options>: A: inhibitor of kappab kinase epsilon (mus musculus) (aka inhibitor of kappab kinase epsilon)
B: nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, epsilon (xenopus tropicalis) (aka nuclear factor of kappa light polypeptide gene enhancer in b-cells i... | [D] |
<Instruct>: Given the context 'I kappa B-epsilon translation initiates from an internal ATG codon to give rise to a protein of 45 kDa, which exists as multiple phosphorylated isoforms in resting cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [i kappa b-epsilon]
<Options>: A: nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, epsilon (xenopus tropicalis) (aka nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, epsilon)
B: nuclear factor of kappa light polypeptide gene enhancer in b cells inhib... | [E] |
<Instruct>: Given the context 'Unlike the other inhibitors, it is found almost exclusively in complexes containing RelA and/or cRel.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rela; crel]
<Options>: A: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
B: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit pseudogene)
C: cation transport regulator-like protein 2-like (glycine max) (aka catio... | [J; K] |
<Instruct>: Given the context 'Unlike the other inhibitors, it is found almost exclusively in complexes containing RelA and/or cRel.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rela; crel]
<Options>: A: rel proto-oncogene, nf-kb subunit (homo sapiens) (aka rel proto-oncogene, nf-kb subunit)
B: crep (homo sapiens) (aka protein phosphatase 1 regulatory subunit 15b)
C: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit pseudogene)
D:... | [G; K] |
<Instruct>: Given the context 'Upon activation, I kappa B-epsilon protein is degraded with slow kinetics by a proteasome-dependent mechanism.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [i kappa b-epsilon]
<Options>: A: i-kappa-b-zeta (homo sapiens) (aka nfkb inhibitor zeta)
B: inhibitor of kappab kinase epsilon (mus musculus) (aka inhibitor of kappab kinase epsilon)
C: inhibitor of nuclear factor kappa b kinase subunit epsilon (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase... | [C] |
<Instruct>: Given the context 'Similarly to I kappa B-alpha', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [i kappa b-alpha]
<Options>: A: ikkb (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
B: nf-kappa-b1 (homo sapiens) (aka nuclear factor kappa b subunit 1)
C: ikk-alpha (homo sapiens) (aka component of inhibitor of nuclear factor kappa b kinase complex)
D: nfkbia (homo sapiens) (a... | [D] |
<Instruct>: Given the context 'and I kappa B, I kappa B-epsilon contains multiple ankyrin repeats and two conserved serines which are necessary for signal-induced degradation of the molecule.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one... | <Mentions>: [i kappa b-epsilon]
<Options>: A: inhibitor of kappab kinase epsilon (mus musculus) (aka inhibitor of kappab kinase epsilon)
B: ikk-e (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit epsilon)
C: i-kappa-b-zeta (homo sapiens) (aka nfkb inhibitor zeta)
D: ikb-epsilon (mus musculus) (aka ... | [B] |
<Instruct>: Given the context 'Unlike I kappa B- alpha and I kappa B-beta, I kappa B-epsilon does not contain a C-terminal PEST-like sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [i kappa b- alpha; i kappa b-beta; i kappa b-epsilon]
<Options>: A: ikba (homo sapiens) (aka nfkb inhibitor alpha)
B: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
C: nfkbib (homo sapiens) (aka nfkb inhibitor beta)
D: ikk-e (homo sapiens) (aka inhibitor of nuclear fa... | [A; C; D] |
<Instruct>: Given the context 'Unlike I kappa B- alpha and I kappa B-beta, I kappa B-epsilon does not contain a C-terminal PEST-like sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [i kappa b- alpha; i kappa b-beta; i kappa b-epsilon]
<Options>: A: nfi-b (homo sapiens) (aka nuclear factor i b)
B: nfkbib (homo sapiens) (aka nfkb inhibitor beta)
C: ikk-alpha (homo sapiens) (aka component of inhibitor of nuclear factor kappa b kinase complex)
D: i-kappa-b-zeta (homo sapiens) (aka nfkb in... | [M; B; G] |
<Instruct>: Given the context 'Unlike I kappa B- alpha and I kappa B-beta, I kappa B-epsilon does not contain a C-terminal PEST-like sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [i kappa b- alpha; i kappa b-beta; i kappa b-epsilon]
<Options>: A: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
B: i-kappa-b-epsilon (mus musculus) (aka nuclear factor of kappa light polypeptide gene enhancer in b cells inhibitor, epsilon)
C: nfi-b (homo sapien... | [K; N; L] |
<Instruct>: Given the context 'Unlike I kappa B- alpha and I kappa B-beta, I kappa B-epsilon does not contain a C-terminal PEST-like sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [i kappa b- alpha; i kappa b-beta; i kappa b-epsilon]
<Options>: A: nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, epsilon (xenopus tropicalis) (aka nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, epsilon)
B: ikk-e (homo sapiens) (aka inhibitor of... | [D; J; B] |
<Instruct>: Given the context 'I kappa B-epsilon would, therefore, appear to regulate a late, transient activation of a subset of genes, regulated by RelA/cRel NF-kappa B complexes, distinct from those regulated by other I kappa B proteins.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [i kappa b-epsilon; rela; crel; nf-kappa b]
<Options>: A: rela (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
B: crrl (arabidopsis thaliana) (aka chaperone dnaj-domain superfamily protein)
C: light-regulated protein-like (glycine max) (aka light-regulated protein-like)
D: nfkbib (homo sapiens) (aka... | [M; A; T; F] |
<Instruct>: Given the context 'I kappa B-epsilon would, therefore, appear to regulate a late, transient activation of a subset of genes, regulated by RelA/cRel NF-kappa B complexes, distinct from those regulated by other I kappa B proteins.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [i kappa b-epsilon; rela; crel; nf-kappa b]
<Options>: A: probable catabolite repression protein crec (glycine max) (aka probable catabolite repression protein crec)
B: i-kappa-b-zeta (homo sapiens) (aka nfkb inhibitor zeta)
C: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-k... | [R; S; S; P] |
<Instruct>: Given the context 'I kappa B-epsilon would, therefore, appear to regulate a late, transient activation of a subset of genes, regulated by RelA/cRel NF-kappa B complexes, distinct from those regulated by other I kappa B proteins.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [i kappa b-epsilon; rela; crel; nf-kappa b]
<Options>: A: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
B: nf-kappab (homo sapiens) (aka nuclear factor kappa b subunit 1)
C: nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, epsilon (xenopu... | [K; F; U; T] |
<Instruct>: Given the context 'I kappa B-epsilon would, therefore, appear to regulate a late, transient activation of a subset of genes, regulated by RelA/cRel NF-kappa B complexes, distinct from those regulated by other I kappa B proteins.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [i kappa b-epsilon; rela; crel; nf-kappa b]
<Options>: A: crep (homo sapiens) (aka protein phosphatase 1 regulatory subunit 15b)
B: nf-kb2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
C: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
D: nfkbib (homo sapie... | [I; C; S; G] |
<Instruct>: Given the context 'I kappa B-epsilon would, therefore, appear to regulate a late, transient activation of a subset of genes, regulated by RelA/cRel NF-kappa B complexes, distinct from those regulated by other I kappa B proteins.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [i kappa b-epsilon; rela; crel; nf-kappa b]
<Options>: A: nfkbib (homo sapiens) (aka nfkb inhibitor beta)
B: probable catabolite repression protein crec (glycine max) (aka probable catabolite repression protein crec)
C: nfkb inhibitor epsilon (homo sapiens) (aka nfkb inhibitor epsilon)
D: nf-kappab (homo sa... | [M; F; T; D] |
<Instruct>: Given the context 'Characterization of VPS41, a gene required for vacuolar trafficking and high-affinity iron transport in yeast.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vps41]
<Options>: A: vps41 (homo sapiens) (aka vps41 subunit of hops complex)
B: transmembrane protein 41 homolog (caenorhabditis elegans) (aka transmembrane protein 41 homolog)
C: vps41 (drosophila melanogaster) (aka light)
D: vps41p (saccharomyces cerevisiae s288c) (aka vps41p)
E: vacuolar protein sortin... | [D] |
<Instruct>: Given the context 'Mutations in the yeast gene VPS41 give rise to poor growth on low iron medium, severe alterations in vacuolar morphology, and cause the missorting of membranous and soluble vacuolar proteins.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [vps41]
<Options>: A: hvsp41 (homo sapiens) (aka vps41 subunit of hops complex)
B: vacuolar protein sorting-associated protein 41 homolog (caenorhabditis elegans) (aka vacuolar protein sorting-associated protein 41 homolog)
C: vps41p (saccharomyces cerevisiae s288c) (aka vps41p)
D: vps41 (drosophila melanog... | [C] |
<Instruct>: Given the context 'Our studies predict that VPS41 encodes a hydrophilic protein of 992 amino acids that contains no obvious signal sequence or hydrophobic domains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [vps41]
<Options>: A: vacuolar protein sorting-associated protein 41 homolog (caenorhabditis elegans) (aka vacuolar protein sorting-associated protein 41 homolog)
B: vps41p (saccharomyces cerevisiae s288c) (aka vps41p)
C: vps41 subunit of hops complex (homo sapiens) (aka vps41 subunit of hops complex)
D: tr... | [B] |
<Instruct>: Given the context 'The deduced Vps41p sequence contains a domain rich in glutamic and aspartic residues, as well as a domain with resemblance to a region of clathrin heavy chain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one ... | <Mentions>: [vps41p]
<Options>: A: atg41p (saccharomyces cerevisiae s288c) (aka atg41p)
B: vacuolar protein sorting-associated protein 41 homolog (caenorhabditis elegans) (aka vacuolar protein sorting-associated protein 41 homolog)
C: vps41p (saccharomyces cerevisiae s288c) (aka vps41p)
D: vps41p (candida albicans sc53... | [C] |
<Instruct>: Given the context 'The VPS41 homologues (but not the yeast VPS41 itself) contain a conserved cysteine-rich RING-H2 zinc finger at their COOH termini.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [vps41]
<Options>: A: vps41 (drosophila melanogaster) (aka light)
B: vps41 (saccharomyces cerevisiae s288c) (aka vps41p)
C: vacuolar protein sorting-associated protein 41 homolog (caenorhabditis elegans) (aka vacuolar protein sorting-associated protein 41 homolog)
D: transmembrane protein 41 homolog (caenor... | [B] |
<Instruct>: Given the context 'Biochemical experiments suggest that VPS41 functions in post-Golgi protein processing: the deletion mutant exhibits defective high affinity transport due to impaired Fet3p activity and also exhibits defects in the processing and sorting of multiple vacuolar hydrolases.', select the correc... | <Mentions>: [vps41; fet3p]
<Options>: A: fthl3p (homo sapiens) (aka ferritin heavy chain 1 pseudogene 3)
B: fer3-like bhlh transcription factor (xenopus tropicalis) (aka fer3-like bhlh transcription factor)
C: ferry endosomal rab5 effector complex subunit 3 (xenopus tropicalis) (aka ferry endosomal rab5 effector comple... | [J; D] |
<Instruct>: Given the context 'Biochemical experiments suggest that VPS41 functions in post-Golgi protein processing: the deletion mutant exhibits defective high affinity transport due to impaired Fet3p activity and also exhibits defects in the processing and sorting of multiple vacuolar hydrolases.', select the correc... | <Mentions>: [vps41; fet3p]
<Options>: A: fthl3p (homo sapiens) (aka ferritin heavy chain 1 pseudogene 3)
B: vps41 (homo sapiens) (aka vps41 subunit of hops complex)
C: transcription factor 3 pseudogene 1 (homo sapiens) (aka transcription factor 3 pseudogene 1)
D: vps41 (drosophila melanogaster) (aka light)
E: vacuolar ... | [I; G] |
<Instruct>: Given the context 'Isolation of a full-length human WNT7A gene implicated in limb development and cell transformation, and mapping to chromosome 3p25.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [wnt7a]
<Options>: A: wnt-7a (xenopus laevis) (wingless-type mmtv integration site family member 7a s homeolog (xenopus laevis)) (aka wingless-type mmtv integration site family member 7a s homeolog)
B: wnt family member 7a (homo sapiens) (aka wnt family member 7a)
C: wnt family member 7a (gallus gallus) (ak... | [B] |
<Instruct>: Given the context 'One mouse member, Wnt7a, is vital for limb development in vivo and also possesses transforming ability in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [wnt7a]
<Options>: A: wnt7c-a (xenopus laevis) (wingless-type mmtv integration site family, member 7c s homeolog (xenopus laevis)) (aka wingless-type mmtv integration site family, member 7c s homeolog)
B: wnt family member 7a (xenopus tropicalis) (aka wnt family member 7a)
C: wnt-7a (homo sapiens) (aka wnt ... | [C] |
<Instruct>: Given the context 'This study reports the isolation of a full length of human homologue of mouse Wnt7a gene by library screening.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [wnt7a]
<Options>: A: wnt family member 7b (homo sapiens) (aka wnt family member 7b)
B: wnt-7a (xenopus laevis) (wingless-type mmtv integration site family member 7a s homeolog (xenopus laevis)) (aka wingless-type mmtv integration site family member 7a s homeolog)
C: wnt7a (homo sapiens) (aka wnt family mem... | [C] |
<Instruct>: Given the context 'Yeast artificial chromosome-fluorescence in situ hybridisation (YAC-FISH) mapped the WNT7A gene to chromosome 3p25.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [wnt7a]
<Options>: A: wnt family member 7b (homo sapiens) (aka wnt family member 7b)
B: wnt7a (xenopus tropicalis) (aka wnt family member 7a)
C: wnt family member 7a (homo sapiens) (aka wnt family member 7a)
D: wnt7c-a (xenopus laevis) (wingless-type mmtv integration site family, member 7c s homeolog (xenop... | [C] |
<Instruct>: Given the context 'Human WNT7A had an ORF encoding a deduced protein of 349 aa that exhibited 97% and 92% identity to mouse Wnt7a at the aa and nucleic acid levels, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one ... | <Mentions>: [wnt7a]
<Options>: A: wnt family member 7a (gallus gallus) (aka wnt family member 7a)
B: wnt family member 7b (homo sapiens) (aka wnt family member 7b)
C: wnt7a (xenopus tropicalis) (aka wnt family member 7a)
D: wnt-7a (xenopus laevis) (wingless-type mmtv integration site family member 7a s homeolog (xenopu... | [E] |
<Instruct>: Given the context 'The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [smad7]
<Options>: A: smad7 (drosophila melanogaster) (aka daughters against dpp)
B: smad family member 5 (mus musculus) (aka smad family member 5)
C: smad family member 7 (homo sapiens) (aka smad family member 7)
D: smad7 (mus musculus) (aka smad family member 7)
E: smad (drosophila melanogaster) (mothers ... | [C] |
<Instruct>: Given the context 'TGFbeta signaling is initiated when the type I receptor phosphorylates the MAD-related protein, Smad2, on C-terminal serine residues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [smad2]
<Options>: A: smad family member 2 (mus musculus) (aka smad family member 2)
B: hsmad2 (homo sapiens) (smad family member 2 (homo sapiens)) (aka smad family member 2)
C: smad2/3 (drosophila melanogaster) (aka smad on x)
D: None of the above. | [B] |
<Instruct>: Given the context 'This leads to Smad2 association with Smad4, translocation to the nucleus, and regulation of transcriptional responses.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad2; smad4]
<Options>: A: madh4 (homo sapiens) (aka smad family member 4)
B: smad family member 4 (mus musculus) (aka smad family member 4)
C: smad4 (drosophila melanogaster) (aka medea)
D: mad4 (homo sapiens) (aka max dimerization protein 4)
E: smad2/3 (drosophila melanogaster) (aka smad on x)
F: smad f... | [H; A] |
<Instruct>: Given the context 'This leads to Smad2 association with Smad4, translocation to the nucleus, and regulation of transcriptional responses.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad2; smad4]
<Options>: A: smad4 (drosophila melanogaster) (aka medea)
B: smad2/3 (drosophila melanogaster) (aka smad on x)
C: mad4 (homo sapiens) (aka max dimerization protein 4)
D: smad family member 5 (homo sapiens) (aka smad family member 5)
E: smad family member 4 (mus musculus) (aka smad family memb... | [H; G] |
<Instruct>: Given the context 'This leads to Smad2 association with Smad4, translocation to the nucleus, and regulation of transcriptional responses.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad2; smad4]
<Options>: A: smad4 (drosophila melanogaster) (aka medea)
B: dpc4 (homo sapiens) (aka smad family member 4)
C: smad family member 5 (homo sapiens) (aka smad family member 5)
D: smad family member 4 (mus musculus) (aka smad family member 4)
E: smad-2 (mus musculus) (aka smad family member 2)
F... | [G; B] |
<Instruct>: Given the context 'Here we demonstrate that Smad7 is an inhibitor of TGFbeta signaling.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad7]
<Options>: A: smad family member 7 (homo sapiens) (aka smad family member 7)
B: smad family member 5 (mus musculus) (aka smad family member 5)
C: smad family member 6 (homo sapiens) (aka smad family member 6)
D: smad7 (drosophila melanogaster) (aka daughters against dpp)
E: smad (drosophila melanoga... | [A] |
<Instruct>: Given the context 'Smad7 prevents TGFbeta-dependent formation of Smad2/Smad4 complexes and inhibits the nuclear accumulation of Smad2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad7; smad2; smad4]
<Options>: A: smad2/3 (drosophila melanogaster) (aka smad on x)
B: smad family member 7 (homo sapiens) (aka smad family member 7)
C: madh4 (homo sapiens) (aka smad family member 4)
D: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
E: smad7 (drosophila melanogaster... | [B; I; C] |
<Instruct>: Given the context 'Smad7 prevents TGFbeta-dependent formation of Smad2/Smad4 complexes and inhibits the nuclear accumulation of Smad2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad7; smad2; smad4]
<Options>: A: smad family member 7 (homo sapiens) (aka smad family member 7)
B: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
C: smad (drosophila melanogaster) (mothers against dpp (drosophila melanogaster)) (aka mothers against dpp)
D: smad family member 6 (mus ... | [A; I; M] |
<Instruct>: Given the context 'Smad7 prevents TGFbeta-dependent formation of Smad2/Smad4 complexes and inhibits the nuclear accumulation of Smad2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad7; smad2; smad4]
<Options>: A: dpc4 (homo sapiens) (aka smad family member 4)
B: smad family member 6 (mus musculus) (aka smad family member 6)
C: smad7 (drosophila melanogaster) (aka daughters against dpp)
D: smad4 (drosophila melanogaster) (aka medea)
E: smad family member 4 (xenopus tropicalis) (aka... | [M; L; A] |
<Instruct>: Given the context 'Smad7 interacts stably with the activated TGFbeta type I receptor, thereby blocking the association, phosphorylation, and activation of Smad2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [smad7; tgfbeta type i receptor; smad2]
<Options>: A: transforming growth factor beta receptor i (xenopus tropicalis) (aka transforming growth factor beta receptor i)
B: tgfr-1 (homo sapiens) (aka transforming growth factor beta receptor 1)
C: smad family member 6 (mus musculus) (aka smad family member 6)
D... | [M; B; H] |
<Instruct>: Given the context 'Smad7 interacts stably with the activated TGFbeta type I receptor, thereby blocking the association, phosphorylation, and activation of Smad2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [smad7; tgfbeta type i receptor; smad2]
<Options>: A: smad (drosophila melanogaster) (mothers against dpp (drosophila melanogaster)) (aka mothers against dpp)
B: transforming growth factor beta receptor i (xenopus tropicalis) (aka transforming growth factor beta receptor i)
C: smad family member 2 (mus musc... | [J; D; G] |
<Instruct>: Given the context 'Smad7 interacts stably with the activated TGFbeta type I receptor, thereby blocking the association, phosphorylation, and activation of Smad2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [smad7; tgfbeta type i receptor; smad2]
<Options>: A: smad7 (drosophila melanogaster) (aka daughters against dpp)
B: smad family member 6 (homo sapiens) (aka smad family member 6)
C: smad (drosophila melanogaster) (mothers against dpp (drosophila melanogaster)) (aka mothers against dpp)
D: smad family membe... | [D; G; F] |
<Instruct>: Given the context 'Furthermore, mutations in Smad7 that interfere with receptor binding disrupt its inhibitory activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad7]
<Options>: A: smad7 (homo sapiens) (aka smad family member 7)
B: smad family member 6 (homo sapiens) (aka smad family member 6)
C: smad (drosophila melanogaster) (mothers against dpp (drosophila melanogaster)) (aka mothers against dpp)
D: smad family member 5 (mus musculus) (aka smad family member 5... | [A] |
<Instruct>: Given the context 'SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sox22]
<Options>: A: sox2.s (xenopus laevis) (sry-box 2 s homeolog (xenopus laevis)) (aka sry-box 2 s homeolog)
B: sox22 (homo sapiens) (aka sry-box transcription factor 12)
C: sox27 (homo sapiens) (aka sry-box transcription factor 15)
D: sox21 (homo sapiens) (aka sry-box transcription factor 21)
E: sry-bo... | [B] |
<Instruct>: Given the context 'SOX (SRY box-containing) genes share a particular DNA-binding domain, called HMG, with the mammalian testis-determining gene SRY Several SOX genes have already been shown to be transcription factors involved in the decision of important cell fates during development.', select the correct ... | <Mentions>: [sry]
<Options>: A: sex determining region y (sus scrofa) (aka sex determining region y)
B: sex determining region y (homo sapiens) (aka sex determining region y)
C: sry-a (drosophila melanogaster) (aka serendipity alpha)
D: sry (drosophila melanogaster) (sprouty (drosophila melanogaster)) (aka sprouty)
E: ... | [B] |
<Instruct>: Given the context 'Here we report the cloning of a new human member of the SOX gene family, SOX22.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sox22]
<Options>: A: sox20 (homo sapiens) (aka sry-box transcription factor 15)
B: sox22 (homo sapiens) (aka sry-box transcription factor 12)
C: sox2.s (xenopus laevis) (sry-box 2 s homeolog (xenopus laevis)) (aka sry-box 2 s homeolog)
D: transcription factor sox-2-like (homo sapiens) (aka transcription fa... | [B] |
<Instruct>: Given the context 'The SOX22 gene maps to chromosome 20 on band p13 and does not appear to be clustered with any other SOX gene mapped to date.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semi... | <Mentions>: [sox22]
<Options>: A: sox21 (homo sapiens) (aka sry-box transcription factor 21)
B: sox2.s (xenopus laevis) (sry-box 2 s homeolog (xenopus laevis)) (aka sry-box 2 s homeolog)
C: sox28 (homo sapiens) (aka sry-box transcription factor 14)
D: sox20 (homo sapiens) (aka sry-box transcription factor 15)
E: sox22 ... | [E] |
<Instruct>: Given the context 'SOX22 mRNA is expressed in various fetal and adult organs and tissues, suggesting that this gene plays roles in both differentiation and maintenance of several cell types.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected o... | <Mentions>: [sox22]
<Options>: A: sox2.s (xenopus laevis) (sry-box 2 s homeolog (xenopus laevis)) (aka sry-box 2 s homeolog)
B: sox20 (homo sapiens) (aka sry-box transcription factor 15)
C: sox22 (homo sapiens) (aka sry-box transcription factor 12)
D: transcription factor sox-2-like (homo sapiens) (aka transcription fa... | [C] |
<Instruct>: Given the context 'A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected ... | <Mentions>: [retinal degeneration c; rdgc]
<Options>: A: primary retinal dysplasia (homo sapiens) (aka primary retinal dysplasia)
B: retinal degeneration d (drosophila melanogaster) (aka retinal degeneration d)
C: rdgb2 (homo sapiens) (aka phosphatidylinositol transfer protein membrane associated 2)
D: retinal degenera... | [D; D] |
<Instruct>: Given the context 'A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected ... | <Mentions>: [retinal degeneration c; rdgc]
<Options>: A: retinal degeneration a (drosophila melanogaster) (aka retinal degeneration a)
B: retinal degeneration c (drosophila melanogaster) (aka retinal degeneration c)
C: retinal degeneration 3-like (gallus gallus) (aka retinal degeneration 3-like)
D: retgc (homo sapiens)... | [B; B] |
<Instruct>: Given the context 'Through our transcriptional mapping effort in the Xp22 region, we have isolated by exon trapping a new transcript highly homologous to the Drosophila retinal degeneration C (rdgC) gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [retinal degeneration c; rdgc]
<Options>: A: retinal degeneration h (drosophila melanogaster) (aka retinal degeneration h)
B: rdgca (homo sapiens) (aka integral membrane protein 2b)
C: retinal degeneration 3-like (gallus gallus) (aka retinal degeneration 3-like)
D: retinal cone dystrophy 1 (homo sapiens) (a... | [F; F] |
<Instruct>: Given the context 'Through our transcriptional mapping effort in the Xp22 region, we have isolated by exon trapping a new transcript highly homologous to the Drosophila retinal degeneration C (rdgC) gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [retinal degeneration c; rdgc]
<Options>: A: retinal cone dystrophy 1 (homo sapiens) (aka retinal cone dystrophy 1)
B: retinal degeneration d (drosophila melanogaster) (aka retinal degeneration d)
C: retgc (homo sapiens) (aka guanylate cyclase 2d, retinal)
D: rd3 (homo sapiens) (aka rd3 regulator of gucy2d)... | [E; E] |
<Instruct>: Given the context 'rdgC encodes a serine/threonine phosphatase protein and is required in Drosophila to prevent light-induced retinal degeneration.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [rdgc]
<Options>: A: rdgc (escherichia coli str. k-12 substr. mg1655) (aka nucleoid-associated protein rdgc)
B: rdgc (drosophila melanogaster) (aka retinal degeneration c)
C: rdgb1 (homo sapiens) (aka phosphatidylinositol transfer protein membrane associated 1)
D: retinal degeneration g (drosophila melanoga... | [B] |
<Instruct>: Given the context 'This human gene is the first mammalian member of the serine-threonine phosphatase with EF hand motif gene family, and was thus named PPEF (Protein Phosphatase with EF calcium-binding domain).', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [ppef]
<Options>: A: ppef1 (homo sapiens) (aka protein phosphatase with ef-hand domain 1)
B: pedf (homo sapiens) (aka serpin family f member 1)
C: ppef1 (bos taurus) (aka protein phosphatase with ef-hand domain 1)
D: ppef2 (homo sapiens) (aka protein phosphatase with ef-hand domain 2)
E: ppef-1 (mus musculu... | [A] |
<Instruct>: Given the context 'The expression pattern of the mouse Ppef gene was studied by RNA in situ hybridization on embryonic tissue sections.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ppef]
<Options>: A: ppef (homo sapiens) (aka protein phosphatase with ef-hand domain 1)
B: ppef-1 (mus musculus) (aka protein phosphatase with ef hand calcium-binding domain 1)
C: ppef2 (homo sapiens) (aka protein phosphatase with ef-hand domain 2)
D: pedf (homo sapiens) (aka serpin family f member 1)
E: p... | [B] |
<Instruct>: Given the context 'While rdgC is expressed in the visual system of the fly, as well as in the mushroom bodies of the central brain, we found that Ppef is highly expressed in sensory neurons of the dorsal root ganglia (DRG) and neural crest-derived cranial ganglia.', select the correct biomedical concept for... | <Mentions>: [rdgc; ppef]
<Options>: A: ppef1 (homo sapiens) (aka protein phosphatase with ef-hand domain 1)
B: ppef1 (xenopus tropicalis) (aka protein phosphatase, ef-hand calcium binding domain 1)
C: epf (homo sapiens) (aka heat shock protein family e (hsp10) member 1)
D: ppef2 (homo sapiens) (aka protein phosphatase ... | [G; J] |
<Instruct>: Given the context 'While rdgC is expressed in the visual system of the fly, as well as in the mushroom bodies of the central brain, we found that Ppef is highly expressed in sensory neurons of the dorsal root ganglia (DRG) and neural crest-derived cranial ganglia.', select the correct biomedical concept for... | <Mentions>: [rdgc; ppef]
<Options>: A: ppef1 (mus musculus) (aka protein phosphatase with ef hand calcium-binding domain 1)
B: ppef2 (homo sapiens) (aka protein phosphatase with ef-hand domain 2)
C: retgc (homo sapiens) (aka guanylate cyclase 2d, retinal)
D: epf (homo sapiens) (aka heat shock protein family e (hsp10) m... | [J; A] |
<Instruct>: Given the context 'While rdgC is expressed in the visual system of the fly, as well as in the mushroom bodies of the central brain, we found that Ppef is highly expressed in sensory neurons of the dorsal root ganglia (DRG) and neural crest-derived cranial ganglia.', select the correct biomedical concept for... | <Mentions>: [rdgc; ppef]
<Options>: A: retgc (homo sapiens) (aka guanylate cyclase 2d, retinal)
B: ppef1 (xenopus tropicalis) (aka protein phosphatase, ef-hand calcium binding domain 1)
C: rdgca (homo sapiens) (aka integral membrane protein 2b)
D: ppef1 (bos taurus) (aka protein phosphatase with ef-hand domain 1)
E: re... | [I; F] |
<Instruct>: Given the context 'The selective pattern of expression makes PPEF an important marker for sensory neuron differentiation and suggests a role for serine-threonine phosphatases in mammalian development.', select the correct biomedical concept for each mention using the provided options. Answer by listing the ... | <Mentions>: [ppef]
<Options>: A: ppef-1 (mus musculus) (aka protein phosphatase with ef hand calcium-binding domain 1)
B: epf (homo sapiens) (aka heat shock protein family e (hsp10) member 1)
C: ppef1 (bos taurus) (aka protein phosphatase with ef-hand domain 1)
D: pedf (homo sapiens) (aka serpin family f member 1)
E: p... | [E] |
<Instruct>: Given the context 'Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hogg1; ogg1]
<Options>: A: hgh1 (homo sapiens) (aka hgh1 cochaperone)
B: hoga1 (homo sapiens) (aka 4-hydroxy-2-oxoglutarate aldolase 1)
C: ogg1 (drosophila melanogaster) (aka 8-oxoguanine dna glycosylase)
D: ogg1 (oryctolagus cuniculus) (aka 8-oxoguanine dna glycosylase)
E: ogh1 (homo sapiens) (aka 8-oxogu... | [E; I] |
<Instruct>: Given the context 'Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hogg1; ogg1]
<Options>: A: hhg1 (homo sapiens) (aka sonic hedgehog signaling molecule)
B: hoga1 (homo sapiens) (aka 4-hydroxy-2-oxoglutarate aldolase 1)
C: ogs1 (homo sapiens) (aka midline 1)
D: ogg1 (mus musculus) (aka 8-oxoguanine dna-glycosylase 1)
E: n-glycosylase/dna lyase ogg1 (glycine max) (aka n-gl... | [J; K] |
<Instruct>: Given the context 'The OGG1 gene of Saccharomyces cerevisiae encodes a DNA glycosylase activity that is a functional analog of the Fpg protein from Escherichia coli and excises 7,8-dihydro-8-oxoguanine (8-oxoG) from damaged DNA.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [ogg1; fpg]
<Options>: A: ogg1 (mus musculus) (aka 8-oxoguanine dna-glycosylase 1)
B: fpgt (xenopus tropicalis) (aka fucose-1-phosphate guanylyltransferase)
C: fpgs (xenopus tropicalis) (aka folylpolyglutamate synthase)
D: 8-oxoguanine dna glycosylase (oryctolagus cuniculus) (aka 8-oxoguanine dna glycosylas... | [K; H] |
<Instruct>: Given the context 'The OGG1 gene of Saccharomyces cerevisiae encodes a DNA glycosylase activity that is a functional analog of the Fpg protein from Escherichia coli and excises 7,8-dihydro-8-oxoguanine (8-oxoG) from damaged DNA.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [ogg1; fpg]
<Options>: A: fpg-1 (arabidopsis thaliana) (aka mutm homolog-1)
B: ogg1 (drosophila melanogaster) (aka 8-oxoguanine dna glycosylase)
C: 8-oxoguanine dna glycosylase (homo sapiens) (aka 8-oxoguanine dna glycosylase)
D: fpg1 (homo sapiens) (aka nei like dna glycosylase 1)
E: fpgt (xenopus laevis) ... | [K; F] |
<Instruct>: Given the context 'This protein shares a 38% sequence identity with the yeast Ogg1 protein, adding this novel human gene product to the growing family of enzymes that the repair of oxidatively damaged bases and are related to the E. coli endonuclease III.', select the correct biomedical concept for each men... | <Mentions>: [ogg1; endonuclease iii]
<Options>: A: hogg1 (homo sapiens) (aka 8-oxoguanine dna glycosylase)
B: endonuclease iii (escherichia coli str. k-12 substr. mg1655) (aka endonuclease iii)
C: n-glycosylase/dna lyase ogg1 (glycine max) (aka n-glycosylase/dna lyase ogg1)
D: endonuclease (saccharomyces cerevisiae s28... | [K; B] |
<Instruct>: Given the context 'This protein shares a 38% sequence identity with the yeast Ogg1 protein, adding this novel human gene product to the growing family of enzymes that the repair of oxidatively damaged bases and are related to the E. coli endonuclease III.', select the correct biomedical concept for each men... | <Mentions>: [ogg1; endonuclease iii]
<Options>: A: endonuclease iii (escherichia coli str. k-12 substr. mg1655) (aka endonuclease iii)
B: ogg1 (mus musculus) (aka 8-oxoguanine dna-glycosylase 1)
C: endonuclease v (xenopus tropicalis) (aka endonuclease v)
D: ogg1 (drosophila melanogaster) (aka 8-oxoguanine dna glycosyla... | [K; A] |
<Instruct>: Given the context 'The cloned coding sequence was expressed in an E. coli strain that carried a disrupted fpg gene, the bacterial functional analog of OGG1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [fpg; ogg1]
<Options>: A: fpg2 (homo sapiens) (aka nei like dna glycosylase 3)
B: fpgs (drosophila melanogaster) (aka folylpolyglutamate synthase 1)
C: ogg1 (mus musculus) (aka 8-oxoguanine dna-glycosylase 1)
D: fpg-1 (arabidopsis thaliana) (aka mutm homolog-1)
E: fpg (escherichia coli str. k-12 substr. mg1... | [E; K] |
<Instruct>: Given the context 'The cloned coding sequence was expressed in an E. coli strain that carried a disrupted fpg gene, the bacterial functional analog of OGG1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [fpg; ogg1]
<Options>: A: n-glycosylase/dna lyase ogg1 (glycine max) (aka n-glycosylase/dna lyase ogg1)
B: fpgs (drosophila melanogaster) (aka folylpolyglutamate synthase 1)
C: ogg1 (oryctolagus cuniculus) (aka 8-oxoguanine dna glycosylase)
D: fpgt (homo sapiens) (aka fucose-1-phosphate guanylyltransferase)... | [E; K] |
<Instruct>: Given the context 'The products of the reaction are consistent with an enzymatic activity like the one displayed by the yeast Ogg1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ogg1]
<Options>: A: n-glycosylase/dna lyase ogg1 (glycine max) (aka n-glycosylase/dna lyase ogg1)
B: ogg1 (drosophila melanogaster) (aka 8-oxoguanine dna glycosylase)
C: 8-oxoguanine dna glycosylase (oryctolagus cuniculus) (aka 8-oxoguanine dna glycosylase)
D: ogg1 (mus musculus) (aka 8-oxoguanine dna-glyc... | [F] |
<Instruct>: Given the context 'Moreover, when the human coding sequence was expressed in a yeast strain mutant in OGG1 it was able to complement the spontaneous mutator phenotype.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each me... | <Mentions>: [ogg1]
<Options>: A: 8-oxoguanine dna glycosylase (oryctolagus cuniculus) (aka 8-oxoguanine dna glycosylase)
B: ogg1 (mus musculus) (aka 8-oxoguanine dna-glycosylase 1)
C: ogg1 (drosophila melanogaster) (aka 8-oxoguanine dna glycosylase)
D: n-glycosylase/dna lyase ogg1 (glycine max) (aka n-glycosylase/dna l... | [F] |
<Instruct>: Given the context 'These results make this novel gene (hOGG1) a strong candidate for the human homolog of the yeast OGG1 and suggest an important role of its product in the protection of the genome from the mutagenic effects of the oxidatively damaged purines.', select the correct biomedical concept for eac... | <Mentions>: [hogg1; ogg1]
<Options>: A: n-glycosylase/dna lyase ogg1 (glycine max) (aka n-glycosylase/dna lyase ogg1)
B: hspg1 (homo sapiens) (aka syndecan 2)
C: ogg1 (homo sapiens) (aka 8-oxoguanine dna glycosylase)
D: hoga1 (homo sapiens) (aka 4-hydroxy-2-oxoglutarate aldolase 1)
E: ogg1 (mus musculus) (aka 8-oxoguan... | [C; K] |
<Instruct>: Given the context 'These results make this novel gene (hOGG1) a strong candidate for the human homolog of the yeast OGG1 and suggest an important role of its product in the protection of the genome from the mutagenic effects of the oxidatively damaged purines.', select the correct biomedical concept for eac... | <Mentions>: [hogg1; ogg1]
<Options>: A: hoga1 (homo sapiens) (aka 4-hydroxy-2-oxoglutarate aldolase 1)
B: hhg1 (homo sapiens) (aka sonic hedgehog signaling molecule)
C: ogg1 (drosophila melanogaster) (aka 8-oxoguanine dna glycosylase)
D: hspg1 (homo sapiens) (aka syndecan 2)
E: n-glycosylase/dna lyase ogg1 (glycine max... | [J; K] |
<Instruct>: Given the context 'A minK-HERG complex regulates the cardiac potassium current I(Kr).
MinK is a widely expressed protein of relative molecular mass approximately 15K that forms potassium channels by aggregation with other membrane proteins.', select the correct biomedical concept for each mention using the ... | <Mentions>: [mink; herg]
<Options>: A: eag1 (homo sapiens) (aka potassium voltage-gated channel subfamily h member 1)
B: kcnrg (homo sapiens) (aka potassium channel regulator)
C: mink (homo sapiens) (potassium voltage-gated channel subfamily e regulatory subunit 1 (homo sapiens)) (aka potassium voltage-gated channel su... | [C; E] |
<Instruct>: Given the context 'A minK-HERG complex regulates the cardiac potassium current I(Kr).
MinK is a widely expressed protein of relative molecular mass approximately 15K that forms potassium channels by aggregation with other membrane proteins.', select the correct biomedical concept for each mention using the ... | <Mentions>: [mink; herg]
<Options>: A: mink1 (homo sapiens) (aka misshapen like kinase 1)
B: mink (mus musculus) (potassium voltage-gated channel, isk-related subfamily, member 1 (mus musculus)) (aka potassium voltage-gated channel, isk-related subfamily, member 1)
C: eag1 (homo sapiens) (aka potassium voltage-gated ch... | [E; G] |
<Instruct>: Given the context 'MinK governs ion channel activation, regulation by second messengers, and the function and structure of the ion conduction pathway.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [mink]
<Options>: A: min1 (homo sapiens) (aka cd59 molecule (cd59 blood group))
B: mink (drosophila melanogaster) (aka mitotic spindle and nuclear protein)
C: mina (mus musculus) (aka ribosomal oxygenase 2)
D: mink (homo sapiens) (misshapen like kinase 1 (homo sapiens)) (aka misshapen like kinase 1)
E: mink... | [E] |
<Instruct>: Given the context 'MinK governs ion channel activation, regulation by second messengers, and the function and structure of the ion conduction pathway.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [mink]
<Options>: A: mina (mus musculus) (aka ribosomal oxygenase 2)
B: min1 (homo sapiens) (aka cd59 molecule (cd59 blood group))
C: mink (homo sapiens) (misshapen like kinase 1 (homo sapiens)) (aka misshapen like kinase 1)
D: mink (drosophila melanogaster) (aka mitotic spindle and nuclear protein)
E: None... | [E] |
<Instruct>: Given the context 'Association of minK with a channel protein known as KvLQT1 produces a voltage-gated outward K+ current (I[sK]) resembling the slow cardiac repolarization current (I[Ks]).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [mink; kvlqt1]
<Options>: A: min (mus musculus) (aka apc, wnt signaling pathway regulator)
B: potassium channel, voltage gated kqt-like subfamily q, member 1 (xenopus tropicalis) (aka potassium channel, voltage gated kqt-like subfamily q, member 1)
C: mink1 (mus musculus) (aka misshapen-like kinase 1 (zebra... | [H; F] |
<Instruct>: Given the context 'Association of minK with a channel protein known as KvLQT1 produces a voltage-gated outward K+ current (I[sK]) resembling the slow cardiac repolarization current (I[Ks]).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [mink; kvlqt1]
<Options>: A: kvlqt1 (sus scrofa) (aka potassium voltage-gated channel subfamily q member 1)
B: potassium voltage-gated channel subfamily kqt member 1 (xenopus tropicalis) (aka potassium voltage-gated channel subfamily kqt member 1)
C: minp (homo sapiens) (aka bmerb domain containing 1)
D: kv... | [I; G] |
<Instruct>: Given the context 'HERG, a human homologue of the ether-a-go-go gene of the fruitfly Drosophila melanogaster, encodes a protein that produces the rapidly activating cardiac delayed rectifier (I[Kr]).', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [herg; ether-a-go-go]
<Options>: A: go (drosophila melanogaster) (glucose dehydrogenase (drosophila melanogaster)) (aka glucose dehydrogenase)
B: goe (drosophila melanogaster) (aka gone early)
C: gok (homo sapiens) (aka stromal interaction molecule 1)
D: ether a go-go (drosophila melanogaster) (aka ether a ... | [I; D] |
<Instruct>: Given the context 'HERG, a human homologue of the ether-a-go-go gene of the fruitfly Drosophila melanogaster, encodes a protein that produces the rapidly activating cardiac delayed rectifier (I[Kr]).', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [herg; ether-a-go-go]
<Options>: A: gogo (drosophila melanogaster) (aka golden goal)
B: kcnrg (homo sapiens) (aka potassium channel regulator)
C: girk1 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 3)
D: ether a go-go (drosophila melanogaster) (aka ether a go-go)
E: go-alpha (... | [G; D] |
<Instruct>: Given the context 'Although heterologously expressed HERG channels are largely indistinguishable from native cardiac I(Kr), a role for minK in this current is suggested by the diminished I(Kr) in an atrial tumour line subjected to minK antisense suppression.', select the correct biomedical concept for each ... | <Mentions>: [herg; mink]
<Options>: A: kcnrg (homo sapiens) (aka potassium channel regulator)
B: herg2 (homo sapiens) (aka potassium voltage-gated channel subfamily h member 6)
C: mink (mus musculus) (potassium voltage-gated channel, isk-related subfamily, member 1 (mus musculus)) (aka potassium voltage-gated channel, ... | [E; H] |
<Instruct>: Given the context 'Although heterologously expressed HERG channels are largely indistinguishable from native cardiac I(Kr), a role for minK in this current is suggested by the diminished I(Kr) in an atrial tumour line subjected to minK antisense suppression.', select the correct biomedical concept for each ... | <Mentions>: [herg; mink]
<Options>: A: minp (homo sapiens) (aka bmerb domain containing 1)
B: girk1 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 3)
C: kcng (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 1)
D: mink (mus musculus) (potassium voltage-gated c... | [F; J] |
<Instruct>: Given the context 'Although heterologously expressed HERG channels are largely indistinguishable from native cardiac I(Kr), a role for minK in this current is suggested by the diminished I(Kr) in an atrial tumour line subjected to minK antisense suppression.', select the correct biomedical concept for each ... | <Mentions>: [herg; mink]
<Options>: A: herg1 (homo sapiens) (aka potassium voltage-gated channel subfamily h member 2)
B: herg-2 (homo sapiens) (aka potassium voltage-gated channel subfamily h member 6)
C: eag1 (homo sapiens) (aka potassium voltage-gated channel subfamily h member 1)
D: kcng (homo sapiens) (aka potassi... | [A; I] |
<Instruct>: Given the context 'Here we show that HERG and minK form a stable complex, and that this heteromultimerization regulates I(Kr) activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [herg; mink]
<Options>: A: minp (homo sapiens) (aka bmerb domain containing 1)
B: min (mus musculus) (aka apc, wnt signaling pathway regulator)
C: mina (mus musculus) (aka ribosomal oxygenase 2)
D: herg3 (homo sapiens) (aka potassium voltage-gated channel subfamily h member 7)
E: mink1 (homo sapiens) (aka m... | [G; H] |
<Instruct>: Given the context 'Here we show that HERG and minK form a stable complex, and that this heteromultimerization regulates I(Kr) activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [herg; mink]
<Options>: A: kcng (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 1)
B: mink (mus musculus) (potassium voltage-gated channel, isk-related subfamily, member 1 (mus musculus)) (aka potassium voltage-gated channel, isk-related subfamily, member 1)
C: min1 (homo sap... | [G; D] |
<Instruct>: Given the context 'MinK, through the formation of heteromeric channel complexes, is thus central to the control of the heart rate and rhythm.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [mink]
<Options>: A: mina (mus musculus) (aka ribosomal oxygenase 2)
B: mink (homo sapiens) (potassium voltage-gated channel subfamily e regulatory subunit 1 (homo sapiens)) (aka potassium voltage-gated channel subfamily e regulatory subunit 1)
C: min1 (homo sapiens) (aka cd59 molecule (cd59 blood group))
D... | [B] |
<Instruct>: Given the context 'X-linked IAP is a direct inhibitor of cell-death proteases.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [x-linked iap]
<Options>: A: c-iap1 (homo sapiens) (aka baculoviral iap repeat containing 2)
B: iap-1 (homo sapiens) (aka baculoviral iap repeat containing 3)
C: c-iap1 (xenopus tropicalis) (aka baculoviral iap repeat containing 2)
D: c-iap1 (xenopus laevis) (baculoviral iap repeat containing 2 l homeolog (... | [E] |
<Instruct>: Given the context 'Here we show that human X-chromosome-linked IAP directly inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [x-chromosome-linked iap; caspase-3; caspase-7]
<Options>: A: caspase-3 (drosophila melanogaster) (aka death executioner caspase related to apopain/yama)
B: caspase-3 (xenopus tropicalis) (aka caspase 3, gene 2)
C: casp3 (homo sapiens) (aka caspase 3)
D: xxiap (xenopus laevis) (x-linked inhibitor of apoptos... | [M; C; K] |
<Instruct>: Given the context 'Here we show that human X-chromosome-linked IAP directly inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [x-chromosome-linked iap; caspase-3; caspase-7]
<Options>: A: caspase-7 (mus musculus) (aka caspase 7)
B: ciap1 (xenopus laevis) (baculoviral iap repeat containing 2 l homeolog (xenopus laevis)) (aka baculoviral iap repeat containing 2 l homeolog)
C: caspase 3 (drosophila melanogaster) (death related ice-li... | [E; N; L] |
<Instruct>: Given the context 'Here we show that human X-chromosome-linked IAP directly inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [x-chromosome-linked iap; caspase-3; caspase-7]
<Options>: A: casp3 (homo sapiens) (aka caspase 3)
B: casp-3 (mus musculus) (aka caspase 3)
C: caspase-7 (mus musculus) (aka caspase 7)
D: xxiap (xenopus laevis) (x-linked inhibitor of apoptosis l homeolog (xenopus laevis)) (aka x-linked inhibitor of apoptosis... | [L; A; E] |
<Instruct>: Given the context 'Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fmr1; fxr1; fxr2]
<Options>: A: fmr1 autosomal homolog 2 (homo sapiens) (aka fmr1 autosomal homolog 2)
B: fxrb (homo sapiens) (aka nuclear receptor subfamily 1 group h member 5, pseudogene)
C: fxr1-b (xenopus laevis) (fmr1 autosomal homolog 1 s homeolog (xenopus laevis)) (aka fmr1 autosomal homolog 1 s hom... | [O; E; A] |
<Instruct>: Given the context 'Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fmr1; fxr1; fxr2]
<Options>: A: fxr1-b (xenopus laevis) (fmr1 autosomal homolog 1 s homeolog (xenopus laevis)) (aka fmr1 autosomal homolog 1 s homeolog)
B: fxr1-a (xenopus laevis) (fmr1 autosomal homolog 1 s homeolog (xenopus laevis)) (aka fmr1 autosomal homolog 1 s homeolog)
C: fxr1 (homo sapiens) (aka fm... | [N; C; N] |
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