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RAT Coronavirus Infection of Primary RAT Alveolar Epithelial Cells | |
Joint detection of tumor markers with imaging ellipsometry biosensor | Tumor marker detection contributes to the early diagnosis of cancers. However, due to the lack of detection specificity, its results cannot act as a direct evidence to confirm cancer occurrence in clinic. Joint detection of tumor markers may improve the detection specificity. As a trial for clinical diagnosis of hepato... |
Understanding Knowledge and Behaviors Related to CoViD–19 Epidemic in Italian Undergraduate Students: The EPICO Study | Background: On February 2020, the novel coronavirus (2019−nCoV) epidemic began in Italy. In order to contain the spread of the virus, the Italian government adopted emergency measures nationwide, including closure of schools and universities, workplaces and subsequently lockdown. This survey was carried out among Itali... |
Laparoscopic versus open surgery: aerosols and their implications for surgery during the COVID-19 pandemic | |
Addressing challenges for clinical research responses to emerging epidemics and pandemics: a scoping review | BACKGROUND: Major infectious disease outbreaks are a constant threat to human health. Clinical research responses to outbreaks generate evidence to improve outcomes and outbreak control. Experiences from previous epidemics have identified multiple challenges to undertaking timely clinical research responses. This scopi... |
Healthcare workers' attitudes to working during pandemic influenza: a qualitative study | BACKGROUND: Healthcare workers (HCWs) will play a key role in any response to pandemic influenza, and the UK healthcare system's ability to cope during an influenza pandemic will depend, to a large extent, on the number of HCWs who are able and willing to work through the crisis. UK emergency planning will be improved ... |
Attitudes, practices and information needs regarding novel influenza A (H7N9) among employees of food production and operation in Guangzhou, Southern China: a cross-sectional study | BACKGROUND: As of 30 May 2013, 132 human infections with avian influenza A (H7N9) had been reported in 10 Chinese cities. On 17 May 2013, because a chicken infection with H7 subtype avian influenza virus was detected in Guanzhou, Guangzhou became the 11th city to conduct emergency response operations. The goal of this ... |
Societal Learning in Epidemics: Intervention Effectiveness during the 2003 SARS Outbreak in Singapore | BACKGROUND: Rapid response to outbreaks of emerging infectious diseases is impeded by uncertain diagnoses and delayed communication. Understanding the effect of inefficient response is a potentially important contribution of epidemic theory. To develop this understanding we studied societal learning during emerging out... |
Update of the ERS international Adult Respiratory Medicine syllabus for postgraduate training | First published in 2006, the first European core syllabus in Adult Respiratory Medicine was developed with the intention of harmonising education and training throughout Europe. Internationally recognised by the European Union of Medical Specialists and identified as the first document of its kind in respiratory medici... |
Modified tracheal extubation for patients with COVID–19 | |
Mitteilungen des BV Geriatrie | |
Hemagglutinin-esterase-fusion (HEF) protein of influenza C virus | Influenza C virus, a member of the Orthomyxoviridae family, causes flu-like disease but typically only with mild symptoms. Humans are the main reservoir of the virus, but it also infects pigs and dogs. Very recently, influenza C-like viruses were isolated from pigs and cattle that differ from classical influenza C viru... |
Mayo Clinic Strategies for COVID-19 Revisiting the Safety of Health Care Workers | |
Environmental investigation of respiratory pathogens during the Hajj 2016 and 2018 | Abstract Background Respiratory tract infections are common in the context of the Hajj pilgrimage and respiratory pathogens can be transmitted via contact with contaminated surfaces. We sampled surfaces during the Hajj to detect the presence of respiratory bacteria and viruses. Methods Frequently touched surfaces at Me... |
Novel Pharmacotherapies for Recurrent Pericarditis: Current Options in 2020 | ABSTRACT: Recent advances have shown impressive results by anti-interleukin 1 (IL-1) agents in refractory idiopathic recurrent pericarditis. PURPOSE OF REVIEW: We critically discuss the current state of the art of therapy of relapsing pericarditis, with a focus on new pharmacological approaches and on specific clinical... |
Immune responses and protective effects against Japanese encephalitis induced by a DNA vaccine encoding the prM/E proteins of the attenuated SA14-14-2 strain | Japanese encephalitis virus (JEV) is the causal pathogen of Japanese encephalitis (JE), which has become a severe public health problem and is one of the most rapidly spreading mosquito-borne diseases worldwide. Currently, there is no specific treatment for JEV. A vaccine would be an effective measure for reducing morb... |
EV‐D68 infection in children with asthma exacerbation and pneumonia in Mexico City during 2014 autumn | BACKGROUND: Human enterovirus D68 (EV‐D68) recently caused an increase in mild‐to‐severe pediatric respiratory cases in North America and some European countries. Even though few of these children presented with acute paralytic disease, direct causal relationship cannot yet be assumed. OBJECTIVES: The purposes of this ... |
Respiratory rehabilitation in elderly patients with COVID-19: A randomized controlled study | Abstract Background Different degrees of disorders are reported in respiratory function, physical function and psychological function in patients with corona virus disease 2019 (COVID-19), especially in elderly patients. With the experience of improved and discharged COVID-19 patients, timely respiratory rehabilitation... |
The psychosocial implications of COVID-19 for a neurology program in a pandemic epicenter | OBJECTIVE: We discuss the psychosocial implications of the COVID-19 pandemic as self-reported by housestaff and faculty in the NYU Langone Health Department of Neurology, and summarize how our program is responding to these ongoing challenges. METHODS: During the period of May 1–4, 2020, we administered an anonymous el... |
An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus | A new SARS animal model was established by inoculating SARS coronavirus (SARS‐CoV) into rhesus macaques (Macaca mulatta) through the nasal cavity. Pathological pulmonary changes were successively detected on days 5–60 after virus inoculation. All eight animals showed a transient fever 2–3 days after inoculation. Immuno... |
Home testing is no quick fix | UK prime minister Boris Johnson says antibody tests for covid-19 are a game changer, but they may not do much in the short term, argues Michael Le Page |
It Takes a Community to Raise the Prevalence of a Zoonotic Pathogen | By definition, zoonotic pathogens are not strict host-species specialists in that they infect humans and at least one nonhuman reservoir species. The majority of zoonotic pathogens infect and are amplified by multiple vertebrate species in nature, each of which has a quantitatively different impact on the distribution ... |
Notfällige Neurointerventionen, Covid-19 und Thorax-CT: SOP und Literaturübersicht | BACKGROUND AND PURPOSE: To analyze standard operating procedures (SOP) of acute stroke imaging and interventions during COVID-19 pandemic with special emphasis on chest CT within a multimodal stroke protocol. METHODS: A questionnaire was distributed via email to members of the Professional Organization of German Neuror... |
Houttuynia cordata, a novel and selective COX-2 inhibitor with anti-inflammatory activity | Abstract Ethnopharmacological relevance Houttuynia cordata Thunb. (Saururaceae; HC) has been long used in traditional oriental medicine for the treatment of inflammation diseases. Modern research has implicated inducible cyclooxygenase-2 (COX-2) as a key regulator of the inflammatory process. Aim of the study In the pr... |
COVID-19 and Picotechnology: Potential Opportunities | Humanity's challenges are becoming increasingly difficult, and as these challenges become more advanced, the need for effective and intelligent action becomes more apparent. Meanwhile, the novel coronavirus disease (COVID-19) pandemic, which has plagued the world, could be considered as an opportunity to take a step to... |
Do citation trends reflect epidemiologic patterns? Assessing MRSA, emerging and re-emerging pathogens, 1963–2014 | BACKGROUND: A rapid rise in PubMed citations on methicillin-resistant Staphylococcus aureus (MRSA) occurred after 2000, but the relationship of trends in citation to epidemiologic trends for infectious disease is not known. METHODS: We queried PubMed(R), for citations to the following: MRSA, HIV/AIDS, Staphylococcus au... |
Soft-shelled turtle iridovirus enters cells via cholesterol-dependent, clathrin-mediated endocytosis as well as macropinocytosis | Ranaviruses are nucleoplasmic large DNA viruses that can cause major economic losses in the aquaculture industry and pose a severe threat to global ecological diversity. The available literature demonstrates that classifiable members of the genus Ranavirus enter cells via multiple and complicated routes. Here, we demon... |
The porcine deltacoronavirus replication organelle comprises double membrane vesicles and zippered endoplasmic reticulum with double membrane spherules | Porcine deltacoronavirus (PDCoV) was first identified in Hong Kong in 2012 from samples taken from pigs in 2009. PDCoV was subsequently identified in the USA in 2014 in pigs with a history of severe diarrhea and the virus has now been detected in pigs in several countries around the world. Following the development of ... |
An in vitro system for the leader-primed transcription of coronavirus mRNAs. | We have developed an in vitro transcription system which can utilize exogenous leader RNA for mouse hepatitis virus (MHV) 'leader-primed' mRNA transcription. Cytoplasmic extracts containing viral proteins and template RNA were prepared by lysolecithin permeabilization of MHV-infected cells. Synthetic leader RNA which d... |
Should Schools Reopen Early or Late? – Transmission Dynamics of COVID-19 in Children | |
Canine coronavirus in Australian dogs | Objective To estimate the frequency of serum antibodies (IgG and IgM) to canine coronavirus (CCV) in the Australian dog population and evaluate the role of CCV as a causative agent of gastroenteritis. Design A serological survey of antibodies to CCV among different dog populations. Procedure The development and charact... |
Improvement in the Reproducibility of a Paper-based Analytical Device (PAD) Using Stable Covalent Binding between Proteins and Cellulose Paper | Paper-based analytical devices (PADs) have been widely used in many fields because they are affordable and portable. For reproducible quantitative analysis, it is crucial to strongly immobilize proteins on PADs. Conventional techniques for immobilizing proteins on PADs are based on physical adsorption, but proteins can... |
Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial | OBJECTIVE: To assess the efficacy and safety of hydroxychloroquine plus standard of care compared with standard of care alone in adults with coronavirus disease 2019 (covid-19). DESIGN: Multicentre, open label, randomised controlled trial. SETTING: 16 government designated covid-19 treatment centres in China, 11 to 29 ... |
Guinea Fowl Coronavirus Diversity Has Phenotypic Consequences for Glycan and Tissue Binding | Guinea fowl coronavirus (GfCoV) causes fulminating enteritis that can result in a daily death rate of 20% in guinea fowl flocks. Here, we studied GfCoV diversity and evaluated its phenotypic consequences. Over the period of 2014 to 2016, affected guinea fowl flocks were sampled in France, and avian coronavirus presence... |
Rhinovirus C and Respiratory Exacerbations in Children with Cystic Fibrosis | To investigate a possible role for human rhinovirus C in respiratory exacerbations of children with cystic fibrosis, we conducted microbiologic testing on respiratory specimens from 103 such patients in São Paulo, Brazil, during 2006–2007. A significant association was found between the presence of human rhinovirus C a... |
Review article: genetic factors that modify the outcome of viral hepatitis | BACKGROUND: Genetic factors can play an important role for treatment response and disease progression in chronic viral hepatitis. AIM: To review the influence of host genetic factors on the clinical course as well as on treatment response in patients with viral hepatitis. METHODS: Review of the literature. RESULTS: A l... |
neuroRAD 2020 Virtual | |
Pulmonary DNA vaccination: Concepts, possibilities and perspectives | Abstract Mucosal immunity establishes the first line of defence against pathogens entering the body via mucosal surfaces. Besides eliciting both local and systemic immunity, mucosal vaccination strategies that are non-invasive in nature may increase patient compliance and reduce the need for vaccine application by trai... |
Transitioning to high efficiency air conditioning in Saudi Arabia: A benefit cost analysis for residential buildings | Abstract This paper assesses the benefits of transitioning to high efficiency air conditioning (AC) equipment for existing units specific to the residential building stock in the Kingdom of Saudi Arabia (KSA). The analysis is based on a calibrated residential building stock model for Saudi Arabia supported by national ... |
Use of Saliva for Diagnosis and Monitoring the SARS-CoV-2: A General Perspective | In this report, updated information and future perspectives about the use of saliva as a sample for laboratory analysis of the Covid-19 are highlighted. Saliva can be used for the direct detection of the SARS-CoV-2 virus, the quantification of the specific immunoglobulins produced against it, and for the evaluation of ... |
Large artery ischaemic stroke in severe acute respiratory syndrome (SARS) | Of the 206 patients who contracted Severe Acute Respiratory Syndrome (SARS) in Singapore five developed large artery cerebral infarctions. Four patients were critically-ill and three died. Intravenous immunoglobulin was given to three patients. An increased incidence of deep venous thrombosis and pulmonary embolism was... |
Persistent Environmental Contamination and Prolonged Viral Shedding in MERS Patients During MERS-CoV Outbreak in South Korea | |
We urgently need guidelines for managing COVID‐19 in children with comorbidities | I read with great interest the systematic review by Ludvigsson on the coronavirus disease 2019 (COVID-19) (1). The author needs to be complimented for a well-timed, rigorous and rapid synthesis of the evidence from the rather scant data available on how the virus affects children. The review, which focused on all paper... |
Efficacy and safety of an attenuated live QX-like infectious bronchitis virus strain as a vaccine for chickens | The attenuation of infectious bronchitis (IB) QX-like virus strain L1148 is described. The virus was passaged multiple times in embryonated specific pathogen free (SPF) chicken eggs, and at different passage levels samples were tested for safety for the respiratory tract and kidneys in 1-day-old SPF chickens. There was... |
Assessing the Evidence Supporting Fruit Bats as the Primary Reservoirs for Ebola Viruses | |
Validation of a digital pathology system including remote review during the COVID-19 pandemic | Remote digital pathology allows healthcare systems to maintain pathology operations during public health emergencies. Existing Clinical Laboratory Improvement Amendments regulations require pathologists to electronically verify patient reports from a certified facility. During the 2019 pandemic of COVID-19 disease, cau... |
Deep splicing plasticity of the human adenovirus type 5 transcriptome drives virus evolution | Viral genomes have high gene densities and complex transcription strategies rendering transcriptome analysis through short-read RNA-seq approaches problematic. Adenovirus transcription and splicing is especially complex. We used long-read direct RNA sequencing to study adenovirus transcription and splicing during infec... |
The Role of Antimicrobial Peptides in Influenza Virus Infection and Their Potential as Antiviral and Immunomodulatory Therapy | Influenza A virus (IAV) remains a major threat that can cause severe morbidity and mortality due to rapid genomic variation. Resistance of IAVs to current anti-IAV drugs has been emerging, and antimicrobial peptides (AMPs) have been considered to be potential candidates for novel treatment against IAV infection. AMPs a... |
Autoinhibition of Bcr-Abl through Its SH3 Domain | Abstract Bcr-Abl is a dysregulated tyrosine kinase whose mechanism of activation is unclear. Here, we demonstrate that, like c-Abl, Bcr-Abl is negatively regulated through its SH3 domain. Kinase activity, transformation, and leukemogenesis by Bcr-Abl are greatly impaired by mutations of the Bcr coiled-coil domain that ... |
More awareness is needed for severe acute respiratory syndrome coronavirus 2019 transmission through exhaled air during non-invasive respiratory support: experience from China | Non-invasive respiratory support plays an essential role in the treatment of COVID-19. More awareness is needed of viral transmission through exhaled air. http://bit.ly/39kNrrF |
Preventive Behavioral Responses to the 2015 Middle East Respiratory Syndrome Coronavirus Outbreak in Korea | This study examined the public’s preventive behavioral responses during the 2015 Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in Korea and the influencing factors. Two cross-sectional telephone surveys were conducted by Gallup Korea using random digit dialing in June 2015 (n = 2004). The main outcom... |
Inferring who-infected-whom-where in the 2016 Zika outbreak in Singapore—a spatio-temporal model | Singapore experienced its first known Zika outbreak in 2016. Given the lack of herd immunity, the suitability of the climate for pathogen transmission, and the year-round presence of the vector—Aedes aegypti—Zika had the potential to become endemic, like dengue. Guillain–Barré syndrome and microcephaly are severe compl... |
Biochemical Microarrays for Studying Chemical Biology Interaction: DiscoveryDot(TM) Technology | DiscoveryDot(TM) is a novel solution‐phase technology for chemical compound microarrays which has been validated for several targets (e.g. serine proteases, cysteine proteases, metalloproteinases, histone deacetylases, phosphatases and various kinases) of significance for drug discovery. The historical context of micro... |
THORACIC RADIOGRAPHIC CHARACTERISTICS OF CANINE INFLUENZA VIRUS IN SIX DOGS | Canine influenza virus is an emerging, highly contagious, respiratory pathogen that has not previously been radiographically described. In this retrospective case series study, we describe the thoracic radiographic appearance of confirmed canine influenza virus in six dogs. Radiographic findings varied, but included ab... |
Processing and antigenicity of entire and anchor-free spike glycoprotein S of coronavirus TGEV expressed by recombinant baculovirus | Abstract The S gene of transmissible gastroenteritis virus (TGEV) was inserted into the genome of Autographa californica nuclear polyhedrosis virus (AcNPV) using the transfer plasmid pVL941. Infection of Sf9 insect cells with the recombinant virus resulted in the synthesis of a 175K polypeptide which was able to trimer... |
Synergistic effect of ribavirin and vaccine for protection during early infection stage of foot-and-mouth disease | In many countries, vaccines are used for the prevention of foot-and-mouth disease (FMD). However, because there is no protection against FMD immediately after vaccination, research and development on antiviral agents is being conducted to induce protection until immunological competence is produced. This study tested w... |
A Sabin 1 poliovirus-based vaccine vector transfects Vero cells with high efficiency | Over the past 40 years, live oral poliovirus (PV) vaccines have contributed to the eradication of wild PV in most countries. These live vaccine strains have a high safety record and can stimulate both cellular and humoral immune responses. As both of these factors are critical characteristics of a good vaccine, we aime... |
Middle East Respiratory Syndrome Vaccine Candidates: Cautious Optimism | Efforts towards developing a vaccine for Middle East respiratory syndrome coronavirus (MERS-CoV) have yielded promising results. Utilizing a variety of platforms, several vaccine approaches have shown efficacy in animal models and begun to enter clinical trials. In this review, we summarize the current progress towards... |
Recent Advances in the Development of Antimicrobial Nanoparticles for Combating Resistant Pathogens | The rapid growth of harmful pathogens and their multidrug‐resistance poses a severe challenge for health professionals and for the development of new healthcare products. Various strategies are exploited for the development of effective antimicrobial agents, and nanoparticles are a particularly promising class of mater... |
Predicting receptor functionality of signaling lymphocyte activation molecule for measles virus hemagglutinin by docking simulation | Predicting susceptibility of various species to a virus assists assessment of risk of interspecies transmission. Evaluation of receptor functionality may be useful in screening for susceptibility. In this study, docking simulation was conducted for measles virus hemagglutinin (MV‐H) and immunoglobulin‐like variable dom... |
COVID ‐19 and the state of African neurology | Expectations of Africa having high rates of infection and death from COVID‐19 have, as yet, not materialised. At the time of writing, all 54 countries have officially reported COVID‐19 cases; 123,724 people have tested positive for the disease and 3,668 people have died. The reasons for such low levels may be due, in p... |
Optimization of antigen dose for a receptor-binding domain-based subunit vaccine against MERS coronavirus | Middle East respiratory syndrome (MERS) is an emerging infectious disease caused by MERS coronavirus (MERS-CoV). The continuous increase of MERS cases has posed a serious threat to public health worldwide, calling for development of safe and effective MERS vaccines. We have previously shown that a recombinant protein c... |
Prevention and control strategies for emergency, limited-term, and elective operations in pediatric surgery during the epidemic period of COVID-19 | The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread to more than 100 countries. Children approved to be susceptible to SARS-CoV-2 infection. Preventing and controlling the epidemic while ensuring orderly flows of pediatric surgery clinica... |
Distribution of Patients at Risk for Complications Related to COVID-19 in the United States: Model Development Study | BACKGROUND: Coronavirus disease (COVID-19) has spread exponentially across the United States. Older adults with underlying health conditions are at an especially high risk of developing life-threatening complications if infected. Most intensive care unit (ICU) admissions and non-ICU hospitalizations have been among pat... |
COVID‐19 and Its Impact on Management Research and Education: Threats, Opportunities and a Manifesto | |
Nanodiagnostics in Microbiology and Dentistry | This chapter presents a general overview of nanodiagnostics in microbiology and dentistry. Nanodiagnostics uses biosensor technology which is one of the most promising, compact systems consisting of a composite analysis of biological recognition element. Detecting an analyte (glucose, antibiotics, etc.) using a transdu... |
Chapter 29 Rapid detection of organophosphates, Ochratoxin A, and Fusarium sp. in durum wheat via screen printed based electrochemical sensors | Publisher Summary Most of the inhibition bioassays or biosensors for organophosphate and carbamate pesticides are based on the amperometric detection of the enzymatic product of the reaction. Applications of amperometric biosensing strategies for pesticide detection in real or spiked food samples have been recently rep... |
The Enigma of Health Literacy and COVID-19 Pandemic | |
Clinical features of 1487 COVID-19 patients with outpatient management in the Greater Paris: the COVID-call study | Clinical features of COVID-19 have been mostly described in hospitalized patients with and without ICU admission. Yet, up to 80% of patients are managed in an outpatient setting. This population is poorly documented. In France, health authorities recommend outpatient management of patients presenting mild-to-moderate C... |
Clinical Signs and Diagnostic Tests in Acute Respiratory Infections | OBJECTIVES: To evaluate clinical manifestations of acute respiratory system infectious diseases and specific tests for causative agents in pediatric patients. METHODS: The authors evaluated children aged 0–16 y with clinical symptoms of acute respiratory tract infections who were administered rapid strep A test and/or ... |
Prediction of Intrinsic Disorder in MERS-CoV/HCoV-EMC Supports a High Oral-Fecal Transmission | A novel coronavirus, MERS-CoV (NCoV, HCoV-EMC/2012), originating from the Middle-East, has been discovered. Incoming data reveal that the virus is highly virulent to humans. A model that categorizes coronaviuses according to the hardness of their shells was developed before the discovery of MERS-CoV. Using protein intr... |
Psychometric Properties of the Greek Version of FCV-19S | As COVID-19 delivered a devastating blow around Europe, unprecedented mental health issues have arisen. This study outlines the Greek translation and validation of the Fear of COVID-19 Scale (FCV-19S) in the general population. A sample of 3029 Greek-speaking individuals completed the FCV-19S, as part of a large online... |
Management of Cardiovascular Disease During Coronavirus Disease (COVID-19) Pandemic | ABSTRACT Patients with pre-existing cardiovascular disease and risk factors are more likely to experience adverse outcomes associated with the novel coronavirus disease-2019 (COVID-19). Additionally, consistent reports of cardiac injury and de novo cardiac complications, including possible myocarditis, arrhythmia, and ... |
Managing Severe Aortic Stenosis in the COVID-19 Era | Abstract The novel coronavirus-19 (COVID-19) pandemic has created uncertainty in the management of patients with severe aortic stenosis (AS). This population experiences high mortality from delays in treatment of valve disease but is largely overlapping with the population of highest mortality from COVID-19. We present... |
Clones of cells from a human embryo lung: Their growth and susceptibility to respiratory viruses | Colonies of cells were obtained from human fetal lung tissue and exposed to recently isolated respiratory viruses. There was a considerable variation in the number of rounded cells found in different colonies exposed to rhinovirus types 2 and 9 (RV2 and 9), human coronavirus 229 E (HCV), adenovirus type 3 (Ad3) and res... |
Decoding the global outbreak of COVID-19: the nature is behind the scene | The sudden emergence of SARS-CoV-2 causing the global pandemic is a major public health concern. Though the virus is considered as a novel entity, it is not a completely new member. It is just a new version of previously emerged human SARS corona virus. The rapid evolving nature by changing host body environment and ex... |
The Scientific Response to a Pandemic | |
Enhanced Induction of SARS-CoV Nucleocapsid Protein-Specific Immune Response Using DNA Vaccination followed by Adenovirus Boosting in BALB/c Mice | OBJECTIVE: To investigate immunogenicity in the induction of humoral and cellular immune responses to genetic vaccines of the recombinant severe acute respiratory syndrome-associated coronavirus (SARS-CoV)-N gene expressing the same protein plasmid, pcDNA3.1-N, and replication-defective adenoviral vector, rAd-N, in a p... |
Three viruses of the bovine respiratory disease complex apply different strategies to initiate infection | Bovine respiratory disease complex (BRDC) is the major cause of serious respiratory tract infections in calves. The disease is multifactorial, with either stress or reduced immunity allowing several pathogens to emerge. We investigated the susceptibility of bovine airway epithelial cells (BAEC) to infection by the thre... |
EMMPRIN/BASIGIN as a biological modulator of oral cancer and COVID-19 interaction: novel propositions | Extracellular matrix metalloproteinase inducer (EMMPRIN), which is also called BASIGIN/CD147, is a cell surface glycoprotein that belongs to the immunoglobulin superfamily and plays a significant role in intercellular recognition in immunology, cellular differentiation and development. Apart from ACE-2, recently EMMPRI... |
AkzoNobel Shows Profitability Improvement for First Quarter despite COVID-19 Impacts | |
Campesin, a thermostable antifungal peptide with highly potent antipathogenic activities | Abstract An 9.4-kDa antifungal peptide designated as campesin was isolated from seeds of the cabbage Brassica campestris. The isolation procedure involved affinity chromatography on Affi-gel blue gel, ion exchange chromatography on Q-Sepharose and Mono S, and gel filtration on Superdex 75 and Superdex Peptide. The pept... |
Intravenous Immunoglobulins: Evolution of Commercial IVIG Preparations | Since its first use in 1952, human immunoglobulin has been used to treat people who have inherited antibody deficiencies. This article summarizes IVIG clinical development in primary immunodeficient patients and manufacturing improvements introduced over time. Manufacturing improvements include purification procedures ... |
Infecciones respiratorias por metapneumovirus en lactantes hospitalizados | Antecedentes El metapneumovirus humano es un virus de reciente descripción al que se atribuyen infecciones respiratorias que afectan fundamentalmente a la población infantil. Objetivos Conocer la incidencia de infecciones por metapneumovirus en lactantes hospitalizados, así como sus características clínicas y la posibl... |
COVID-19 Pandemic and Beyond: Considerations and Costs of Telehealth Exercise Programs for Older Adults With Functional Impairments Living at Home—Lessons Learned from a Pilot Case Study | OBJECTIVE: The purpose of this study was to describe the process and cost of delivering a physical therapist–guided synchronous telehealth exercise program appropriate for older adults with functional limitations. Such programs may help alleviate some of the detrimental impacts of social distancing and quarantine on ol... |
Syphilis in China: results of a national surveillance programme | Summary Background After a massive syphilis epidemic in the first half of the 20th century, China was able to eliminate this infection for 20 years (1960–80). However, substantial changes in Chinese society have been followed by a resurgent epidemic of sexually transmitted diseases. Sporadic reports have provided clues... |
Protracted bacterial bronchitis: The last decade and the road ahead | Cough is the single most common reason for primary care physician visits and, when chronic, a frequent indication for specialist referrals. In children, a chronic cough (>4 weeks) is associated with increased morbidity and reduced quality of life. One common cause of childhood chronic cough is protracted bacterial bron... |
The Argentine Society of Laparoscopic Surgery (SACIL) letter on Covid-19 | |
Predictors of protective behaviors among American travelers to the 2009 Hajj | BACKGROUND Respiratory-borne infectious diseases can spread rapidly at mass gatherings. The 2009 Hajj took place during the influenza A (H1N1) pandemic. This study investigates factors associated with compliance with recommended influenza A (H1N1)-related health practices and behaviors among American pilgrims to the 20... |
Preventing transfer of infectious agents | Abstract Xenotransplantation using pig cells, tissues and organs may be associated with the transfer of porcine infectious agents, which may infect the human recipient and in the worst case induce a disease (zoonosis). To prevent this, a broad screening program of the donor animals for putative zoonotic microorganisms,... |
Respiratory syncytial virus: The virus, the disease and the immune response | Abstract RSV is the primary cause of hospitalisation in the first year of life for children in most parts of the world, and nearly 100% of children in the USA are infected with the virus by 2 to 3 years of age. The agent is an enveloped RNA virus with a non-segmented single-stranded negative-sense genome. The viral gen... |
The COVID-19 pandemic: a systemic analysis | |
Expression of the COVID‐19 receptor ACE2 in the human conjunctiva | SARS‐CoV‐2 is assumed to use angiotensin‐converting enzyme 2 (ACE2) and other auxiliary proteins for cell entry. Recent studies have described conjunctival congestion in 0.8% of patients with laboratory‐confirmed SARS‐CoV‐2, and there has been speculation that SARS‐CoV‐2 can be transmitted through the conjunctiva. Howe... |
Being (more) Human in a Digitized World | |
Lessons from SARS‐CoV‐2 screening in a Brazilian organ transplant unit | Protecting immunosuppressed patients during infectious disease outbreaks is crucial. During this novel coronavirus disease 2019 pandemic, preserving “clean areas” in hospitals assisting organ transplant recipients is key to protect them and to preserve transplantation activity. Evidence suggests that asymptomatic carri... |
Aerosol or droplet: critical definitions in the COVID‐19 era | |
First detection of bovine noroviruses and detection of bovine coronavirus in Australian dairy cattle | BACKGROUND AND OBJECTIVE: Noroviruses have been recognised as a significant cause of neonatal enteritis in calves in many countries, but there has been no investigation of their occurrence in Australian cattle. This study aimed to establish whether bovine noroviruses could be detected in faecal samples from Australian ... |
Porcine Circovirus Type 2 and Porcine Circovirus‐Associated Disease | Porcine circovirus type 2 (PCV2) belongs to the viral family Circoviridae and to the genus Circovirus. Circoviruses are small, single‐stranded nonenveloped DNA viruses that have an unsegmented circular genome. PCV2 is the primary causative agent of several syndromes collectively known as porcine circovirus‐associated d... |
Is lithium a potential treatment for the novel Wuhan (2019-nCoV) coronavirus? A scoping review | The current rapid spread of the novel coronavirus (2019-nCoV) originating from Wuhan, China, calls for a rapid response from the research community Lithium is widely used to treat bipolar disorder, but has been shown to exhibit antiviral activity This brief review took a systematic approach to identify five in vitro st... |
Detection of Signature Sequences in Overlapping Genes and Prediction of a Novel Overlapping Gene in Hepatitis G Virus | In viruses an increased coding ability is provided by overlapping genes, in which two alternative open reading frames (ORFs) may be translated to yield two distinct proteins. The identification of signature sequences in overlapping genes is a topic of particular interest, since additional out-of-frame coding regions ca... |
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