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Association of residential dampness and mold with respiratory tract infections and bronchitis: a meta-analysis | BACKGROUND: Dampness and mold have been shown in qualitative reviews to be associated with a variety of adverse respiratory health effects, including respiratory tract infections. Several published meta-analyses have provided quantitative summaries for some of these associations, but not for respiratory infections. Dem... |
Rapid random access detection of the novel SARS-coronavirus-2 (SARS-CoV-2, previously 2019-nCoV) using an open access protocol for the Panther Fusion | • Detection of SARS-CoV-2 within 3.5 h (sample-to-answer-time) by random access real time PCR. • Adaption of an already published real time PCR for SARS-CoV-2 to a fully automatic, random access PCR system. • Detection of all SARS-CoV (from 2002, which may be soon labelled as SARS-CoV-1, and SARS-CoV-2) with a PCR for ... |
Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model | The current pandemic coronavirus, SARS-CoV-2, was recently identified in patients with an acute respiratory syndrome, COVID-19. To compare its pathogenesis with that of previously emerging coronaviruses, we inoculated cynomolgus macaques with SARS-CoV-2 or MERS-CoV and compared the pathology and virology with historica... |
An infectious bat chimeric influenza virus harboring the entry machinery of a influenza A virus | In 2012 the complete genomic sequence of a new and potentially harmful influenza A-like virus from bats (H17N10) was identified. However, infectious influenza virus was neither isolated from infected bats nor reconstituted, impeding further characterization of this virus. Here we show the generation of an infectious ch... |
How many are we missing with ID NOW COVID-19 assay using direct nasopharyngeal swabs? – Findings from a mid-sized academic hospital clinical microbiology laboratory | Abstract Here, we retrospectively analyzed the comparative results of 182 paired dry nasopharyngeal swabs tested by Abbott ID NOW and nasopharyngeal swabs in viral transport medium by real-time RT-PCR methods. While the overall agreement was 96.2%, we found that of 15 samples that were tested positive with RT-PCR metho... |
A risk-assessment model to rate the occurrence and relevance of adventitious agents in the production of influenza vaccines | Influenza vaccine production has traditionally relied on the use of embryonated chicken eggs for virus isolation and propagation, but recently, cell-culture-derived manufacturing methods have been introduced. During influenza vaccine production, by either conventional or cell culture methods, there is a risk of inciden... |
PROPUESTA DE USO DE ANAKINRA EN EL DISTRESS RESPIRATORIO AGUDO SECUNDARIO A COVID-19 | Resumen El desenlace de la infección por SARS-CoV-2 (COVID-19) afecta fundamentalmente al campo pulmonar, ocasionando un cuadro de SÍNDROME DE DISTRÉS RESPIRATORIO AGUDO (SDRA). Este proceso es un cuadro inflamatorio, protagonizado por una cascada de citocinas bajo el amparo del INFLAMOSOMA NLRP3, responsable principal... |
Risk factors and patterns of household clusters of respiratory viruses in rural Nepal | Viral pneumonia is an important cause of death and morbidity among infants worldwide. Transmission of non-influenza respiratory viruses in households can inform preventative interventions and has not been well-characterised in South Asia. From April 2011 to April 2012, household members of pregnant women enrolled in a ... |
The novel coronavirus (SARS-CoV-2) emergency and the role of timely and effective national health surveillance. | |
Follow-up of convalescent COVID-19 patients by the general practitioner | |
Introducing the “Corona Curtain”: an innovative technique to prevent airborne COVID-19 exposure during emergent intubations | BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic places healthcare workers at risk of exposure to the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Emergency department (ED) staff are particularly vulnerable when managing patients with acute respiratory distress due to the aerosolization of ... |
Animal models for dengue vaccine development and testing | Dengue fever is a tropical endemic disease; however, because of climate change, it may become a problem in South Korea in the near future. Research on vaccines for dengue fever and outbreak preparedness are currently insufficient. In addition, because there are no appropriate animal models, controversial results from v... |
First identification of mammalian orthoreovirus type 3 in diarrheic pigs in Europe | Mammalian Orthoreoviruses 3 (MRV3) have been described in diarrheic pigs from USA and Asia. We firstly detected MRV3 in Europe (Italy) in piglets showing severe diarrhea associated with Porcine Epidemic Diarrhea. The virus was phylogenetically related to European reoviruses of human and bat origin and to US and Chinese... |
Optimization of human, animal, and environmental health by using the One Health approach | Emerging diseases are increasing burdens on public health, negatively affecting the world economy, causing extinction of species, and disrupting ecological integrity. One Health recognizes that human, domestic animal, and wildlife health are interconnected within ecosystem health and provides a framework for the develo... |
Cryptosporidium infection in a veal calf cohort in France: molecular characterization of species in a longitudinal study | Feces from 142 animals were collected on 15 farms in the region of Brittany, France. Each sample was directly collected from the rectum of the animal and identified with the ear tag number. Animals were sampled three times, at 5, 15 and 22 weeks of age. After DNA extraction from stool samples, nested PCR was performed ... |
Occupational skin disease during the COVID‐19 pandemic, as captured in a Dermatology staff clinic in the United Kingdom | A Dermatology walk‐in clinic available to all hospital staff (HS) was commenced to treat skin problems related to personal protective equipment (PPE) during the COVID‐19 pandemic. An observational case series was conducted in a single district general hospital within Wales (United Kingdom) to record the dermatological ... |
Implementing and Monitoring At-Home VR Oculo-kinetic Perimetry During COVID-19 | |
Personal resources and personal demands for work engagement: Evidence from employees in the service industry | Conventional studies have widely demonstrated that individuals’ engagement at work depends on their personal resources, which are affected by environmental influences, especially those derived from the workplace and home domains. In this study, we examine whether a change in work engagement may be based on individuals’... |
Reply to: “Do IL-17 Inhibitors Increase Risk of Respiratory Tract Infections?” | |
The use of biochar in animal feeding | Biochar, that is, carbonized biomass similar to charcoal, has been used in acute medical treatment of animals for many centuries. Since 2010, livestock farmers increasingly use biochar as a regular feed supplement to improve animal health, increase nutrient intake efficiency and thus productivity. As biochar gets enric... |
Respiratory tract virus infections in the elderly with pneumonia | BACKGROUND: In children suffering from severe lower airway illnesses, respiratory virus detection has given good prognostic information, but such reports in the elderly are scarce. Therefore, our aim was to study whether the detection of nasopharyngeal viral pathogens and conventional inflammatory markers in the frail ... |
Social network theory in the behavioural sciences: potential applications | Social network theory has made major contributions to our understanding of human social organisation but has found relatively little application in the field of animal behaviour. In this review, we identify several broad research areas where the networks approach could greatly enhance our understanding of social patter... |
Design, synthesis, antiviral and cytotoxic evaluation of novel acyclic phosphonate nucleotide analogues with a 5,6-dihydro-1H-[1,2,3]triazolo[4,5-d]pyridazine-4,7-dione system | ABSTRACT: A series of diethyl 2-(4,5-dimethoxycarbonyl-1H-1,2,3-triazol-1-yl)alkylphosphonates was synthesised from ω-azidoalkylphosphonates and dimethyl acetylenedicarboxylate and was further transformed into the respective diamides, dihydrazides, and 5,6-dihydro-1H-[1,2,3]triazolo[4,5-d]pyridazine-4,7-diones as phosp... |
Inhibition of hepatitis B virus gene expression and replication by endoribonuclease-prepared siRNA | Abstract Endoribonuclease-prepared siRNA (esiRNA) is an alternative tool to chemical synthetic siRNA for gene silencing. Since esiRNAs are directed against long target sequences, the genetic variations in the target sequences will have little influence on their effectiveness. The ability of esiRNAs to inhibit hepatitis... |
Does recombinant human erythropoietin administration in critically ill COVID‐19 patients have miraculous therapeutic effects? | An 80‐year‐old man with multiple comorbidities presented to the emergency department with tachypnea, tachycardia, fever, and critically low O(2) saturation and definitive chest computerized tomography scan findings in favor of COVID‐19 and positive PCR results in 48 hours. He received antiviral treatment plus recombina... |
Effect of facemasks on empathy and relational continuity: a randomised controlled trial in primary care | BACKGROUND: There is limited evidence to support the use of facemasks in preventing infection for primary care professionals. Negative effects on communication has been suggested when the physician wears a facemask. As communication skills and doctor patient relationship are essential to primary care consultations, the... |
Multiplex reverse transcription loop-mediated isothermal amplification combined with nanoparticle-based lateral flow biosensor for the diagnosis of COVID-19 | The ongoing global pandemic (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a huge public health issue. Hence, we devised a multiplex reverse transcription loop-mediated isothermal amplification (mRT-LAMP) coupled with a nanoparticle-based lateral flow biosensor (LFB) ... |
The impact of the COVID-19 pandemic on marginalized populations in the United States: A research agenda | Abstract International and national crises often highlight inequalities in the labor market that disproportionately affect individuals from marginalized backgrounds. The COVID-19 pandemic, and the resulting changes in society due to social distancing measures, has showcased inequities in access to decent work and exper... |
Informed public against false rumor in the social media era: Focusing on social media dependency | Abstract This study explores how the public’s belief in false rumors about Middle East Respiratory Syndrome that spread across South Korea related to their accuracy-oriented information seeking as well as the moderating effects of people’s reasons for using social networking services (SNS). The survey results show that... |
Conduite à tenir devant une diarrhée aiguë. Étiologies | Résumé Les diarrhées aiguës constituent un problème de santé publique du fait de leur grande fréquence. Leur origine est presque toujours infectieuse et leur évolution spontanément résolutive, le plus souvent en moins de 3 jours. Seul 1 % des diarrhées nécessite d'emblée des explorations complémentaires, notamment des ... |
An Otofuke-like virus associated with diarrhoea. Case report and electronmicroscopic study | Virus particles similar to Otofuke virus have been found, together with rotaviruses and astroviruses, by electronmicroscopy in faeces from an infant with diarrhoea in Northern Ireland. Previously Otofuke virus has been found only in Japan whence it may have been carried to this country by a businessman. |
A tripartite approach can seek to optimize breast cancer management during a pandemic – Real‐Time experience of a developing breast oncology unit in Singapore | |
Contributions of dermatologists to COVID‐19 research: a brief systematic review | Coronavirus Disease 2019 (COVID‐19) has been declared a pandemic. We conducted a systematic review to reveal the contribution of dermatologists in COVID‐19 research. 298 articles were included and classified into cutaneous manifestations of COVID‐19, operating experience against COVID‐19, mechanisms and treatment of CO... |
COVID-19 and the quality use of medicines: evidence, risks and fads | |
The need for accurate D‐dimer reporting in COVID‐19: Communication from the ISTH SSC on Fibrinolysis | The coronavirus disease 2019 (COVID‐19) pandemic continues to claim many lives across the world. In the attempts to identify a reliable prognostic indicator, marked elevation of D‐dimer has been a strong contender.(1,2) In many studies, D‐dimers have consistently been shown to be the most significant marker for illness... |
Public behavior change, perceptions, depression, and anxiety in relation to the COVID-19 outbreak | BACKGROUND: The COVID-19 has spread rapidly and world-widely, which elicits public panic and psychological problems. Public protective behaviors and perception play crucial roles in controlling the spread of illness and psychological status. METHODS: We conducted a cross-sectional online survey in the hardest-hit Hubei... |
Resilience strategies to manage psychological distress amongst healthcare workers during the COVID‐19 pandemic: a narrative review | The COVID‐19 pandemic marks an extraordinary global public health crisis unseen in the last century, with its rapid spread worldwide and associated mortality burden. The longevity of the crisis, and disruption to normality is unknown. With COVID‐19 set to be a chronic health crisis, clinicians will be required to maint... |
Proteomics informed by transcriptomics reveals Hendra virus sensitizes bat cells to TRAIL-mediated apoptosis | BACKGROUND: Bats are a major reservoir of emerging infectious viruses. Many of these viruses are highly pathogenic to humans however bats remain asymptomatic. The mechanism by which bats control viral replication is unknown. Here we utilize an integrated approach of proteomics informed by transcriptomics to compare the... |
Antibody-Based Sensors: Principles, Problems and Potential for Detection of Pathogens and Associated Toxins | Antibody-based sensors permit the rapid and sensitive analysis of a range of pathogens and associated toxins. A critical assessment of the implementation of such formats is provided, with reference to their principles, problems and potential for ‘on-site’ analysis. Particular emphasis is placed on the detection of food... |
SÍNDROME DE GUILLAIN-BARRÉ TRAS INFECCIÓN POR COVID-19 | RESUMEN La infección por COVID-19 declarada pandemia en el 2020 y cuya gravedad está relacionada con el desarrollo de distrés pulmonar, también presenta afectación a otros niveles incluyendo cuadros neurológicos que hasta el momento han pasado más desapercibidos. Nosotros presentamos un caso de un varón de 77 años con ... |
The Role of Selenium in Health and Disease: Emerging and Recurring Trends | In this Special Issue of Nutrients, "The Role of Selenium in Health and Disease" covers diverse diseases in the 8 original research articles and 2 reviews, such as cardiovascular disorders (CVD), metabolic syndrome, obesity, cancer, and viral infection, and highlights novel potential biomarkers of disease risk and prog... |
Decreased angiogenic and increased apoptotic activities of bone microvascular endothelial cells in patients with glucocorticoid-induced osteonecrosis of the femoral head | BACKGROUND: Glucocorticoid-induced osteonecrosis of the femoral head (ONFH) is closely associated with the dysfunction of the bone microvascular endothelial cells (BMECs). The present study investigated the angiogenic and apoptotic activity of the BMECs in glucocorticoid-induced ONFH. METHODS: This study enrolled a tot... |
Tension pneumothorax in a patient with COVID-19 | A 36-year-old man was brought to the emergency department with suspected COVID-19, following a 3-week history of cough, fevers and shortness of breath, worsening suddenly in the preceding 4 hours. On presentation he was hypoxaemic, with an SpO(2) of 88% on 15 L/min oxygen, tachycardic and had no audible breath sounds o... |
Efficacy and safety of Chinese patent medicine injection for COVID-19: A protocol for systematic review and meta-analysis | BACKGROUND: Corona Virus Disease 2019 (COVID-19) has caused a worldwide epidemic since its discovery. The outbreak of virus infection has aroused great concern of the World Health Organization (WHO). COVID-19 is highly infectious and has a high infection rate. So far, no specific drug has been found to cure it. China a... |
Angiotensin converting enzyme-2 (ACE2) and its possible roles in hypertension, diabetes and cardiac function | Angiotensin converting enzyme-2 (ACE2) is a recently described homologue of the vasoactive peptidase, angiotensin converting enzyme (ACE). Like ACE, ACE2 is an integral (type I) membrane zinc metallopeptidase, which exists as an ectoenzyme. ACE2 is less widely distributed than ACE in the body, being expressed at highes... |
Thalassemia in the emergency department: special considerations for a rare disease | Thalassemia is characterized by a defect in the synthesis of one or more of the globin subunits of hemoglobin. This defect results in imbalance in the α/β-globin chain ratio, ineffective erythropoiesis, chronic hemolytic anemia, and iron overload. With advances in diagnosis, treatment, and transfusion support, the prog... |
Pandemia de Covid-19 y transformación digital en Cuidados Intensivos | |
Is the use of laparoscopy in a COVID‐19 epidemic free of risk? | |
The epidemiology and etiology of influenza‐like illness in Chinese children from 2008 to 2010 | Influenza‐like illness can be caused by a wide range of respiratory viruses. In order to investigate the epidemiology of viral pathogens related to influenza‐like illness in children of Wuhan, the largest city in central China, throat swab samples were collected from 1,472 young patients, from July 2008 to June 2010, b... |
Norovirus Regulation of the Innate Immune Response and Apoptosis Occurs via the Product of the Alternative Open Reading Frame 4 | Small RNA viruses have evolved many mechanisms to increase the capacity of their short genomes. Here we describe the identification and characterization of a novel open reading frame (ORF4) encoded by the murine norovirus (MNV) subgenomic RNA, in an alternative reading frame overlapping the VP1 coding region. ORF4 is t... |
Nanoparticle-Based Vaccines Against Respiratory Viruses | The respiratory mucosa is the primary portal of entry for numerous viruses such as the respiratory syncytial virus, the influenza virus and the parainfluenza virus. These pathogens initially infect the upper respiratory tract and then reach the lower respiratory tract, leading to diseases. Vaccination is an affordable ... |
Development of Small‐Molecule Antivirals for Ebola | Ebola hemorrhagic fever is a deadly disease caused by infection with one of the Ebola virus species. Although a significant progress has recently been made in understanding of Ebola virus biology and pathogenesis, development of effective anti‐Ebola treatments has not been very productive, compared to other areas of an... |
Analysis of the Electricity Demand Trends amidst the COVID-19 Coronavirus Pandemic | This paper investigates the impact of COVID-19 and the global pandemic on the energy sector dynamics. Hourly electricity demand data was collected and analyzed for the province of Ontario. It is evident that health-related pandemics have a detrimental and direct influence on the concept of the smart city. This is manif... |
Middle East respiratory syndrome coronavirus in children | The Middle East respiratory syndrome (MERS) is a new human disease caused by a novel coronavirus (CoV). The disease is reported mainly in adults. Data in children are scarce. The disease caused by MERS-CoV in children presents with a wide range of clinical manifestations, and it is associated with a lower mortality rat... |
Determination of host cell proteins constituting the molecular microenvironment of coronavirus replicase complexes by proximity-labeling | Positive-sense RNA viruses hijack intracellular membranes that provide niches for viral RNA synthesis and a platform for interactions with host proteins. However, little is known about host factors at the interface between replicase complexes and the host cytoplasm. We engineered a biotin ligase into a coronaviral repl... |
Barriers to Telemedicine Implementation in Southwest Tribal Communities During COVID‐19 | |
Diagnosis of COVID‐19 pneumonia despite missing detection of viral nucleic acid and initially inconspicuous radiologic findings | The diagnosis of coronavirus disease 2019 (COVID‐19) is mainly based on a positive SARS‐CoV‐2 polymerase chain reaction (PCR) result. PCR samples are obtained from upper or lower respiratory tract specimens. However, the sensitivity of PCR is known to have some limitations. We report on a patient who was admitted to ou... |
Serological evidence of MERS-CoV and HKU8-related CoV co-infection in Kenyan camels | Dromedary camels are important reservoir hosts of various coronaviruses, including Middle East respiratory syndrome coronavirus (MERS-CoV) that cause human infections. CoV genomes regularly undergo recombination during infection as observed in bat SARS-related CoVs. Here we report for the first time that only a small p... |
Making the Mark: The Role of Adenosine Modifications in the Lifecycle of RNA Viruses | Viral epitranscriptomics is a newly emerging field that has identified unique roles for RNA modifications in modulating lifecycles of RNA viruses. Despite the observation of a handful of modified viral RNAs five decades ago, very little was known about how these modifications regulate viral lifecycles, until recently. ... |
Spatio-Temporal Patterns of the 2019-nCoV Epidemic at the County Level in Hubei Province, China | Understanding the spatio-temporal characteristics or patterns of the 2019 novel coronavirus (2019-nCoV) epidemic is critical in effectively preventing and controlling this epidemic. However, no research analyzed the spatial dependency and temporal dynamics of 2019-nCoV. Consequently, this research aims to detect the sp... |
Pattern recognition receptors in equine endotoxaemia and sepsis | Pattern recognition receptors (PRRs) on host cells detect pathogens to activate innate immunity which, in turn, initiates inflammatory and adaptive immune responses. Successful activation of PRRs is, therefore, critical to controlling infections and driving pathogen‐specific adaptive immunity, but overactivity of PRRs ... |
A Universal Influenza A and B Duplex Real‐time RT‐PCR Assay | A high throughput universal influenza A and B duplex real‐time RT‐PCR was developed to meet effectively the heightened surveillance and diagnostic needs essential in managing influenza infections and outbreaks. Primers and probes, designed to target highly conserved regions of the matrix protein of influenza A and the ... |
PER1 prevents excessive innate immune response during endotoxin-induced liver injury through regulation of macrophage recruitment in mice | The severity of acute liver failure (ALF) induced by bacterial lipopolysaccharide (LPS) is associated with the hepatic innate immune response. The core circadian molecular clock modulates the innate immune response by controlling rhythmic pathogen recognition by the innate immune system and daily variations in cytokine... |
Primer caso de infección neonatal por SARS-CoV-2 en España | |
Replication and Expression Analysis of PRRSV Defective RNA | |
Decoy ACE2-expressing extracellular vesicles that competitively bind SARS-CoV-2 as a possible COVID-19 therapy | The novel strain of coronavirus that appeared in 2019, SARS-CoV-2, is the causative agent of severe respiratory disease, COVID-19, and the ongoing pandemic. As for SARS-CoV that caused the SARS 2003 epidemic, the receptor on host cells that promotes uptake, through attachment of the spike (S) protein of the virus, is a... |
Novel Mechanistic Insights into Viral Modulation of Immune Receptor Signaling | |
Effects of superspreaders in spread of epidemic | Abstract Within the standard SIR model with spatial structure, we propose two models for the superspreader. In one model, superspreaders have intrinsically strong infectiousness. In other model, they have many social connections. By Monte Carlo simulation, we obtain the percolation probability, the propagation speed, t... |
Combination of western medicine and Chinese traditional patent medicine in treating a family case of COVID-19 in Wuhan | In December 2019, an outbreak of novel Coronavirus (2019-nCoV) occurred in Wuhan, Hubei Province, China. By February 14, 2020, it has led to 66 492 confirmed patients in China and high mortality up to ∼2.96% (1123/37 914) in Wuhan. Here we report the first family case of coronavirus disease 2019 (COVID-19) confirmed in... |
ACR Statement on Safe Resumption of Routine Radiology Care During the COVID-19 Pandemic | The ACR recognizes that radiology practices are grappling with when and how to safely resume routine radiology care during the coronavirus disease 2019 (COVID-19) pandemic. Although it is unclear how long the pandemic will last, it may persist for many months. Throughout this time, it will be important to perform safe,... |
Establishment of minimal positive-control conditions to ensure brain safety during rapid development of emergency vaccines | With the increase in international human and material exchanges, contagious and infectious epidemics are occurring. One of the effective methods of epidemic inhibition is the rapid development and supply of vaccines. Considering the safety of the brain during vaccine development is very important. However, manuals for ... |
Molecular characterization and pathogenesis of transmissible gastroenteritis coronavirus (TGEV) and porcine respiratory coronavirus (PRCV) field isolates co-circulating in a swine herd | TGEV replicates in intestinal enterocytes and causes diarrhea in young pigs. PRCV, a spike (S) gene deletion mutant of TGEV with an altered respiratory tissue tropism, causes mild or subclinical respiratory infections. Comparisons of TGEV and PRCV strains suggest that tropism and pathogenicity are influenced by the S g... |
¿Brotará una mejor salud pública tras la COVID-19? | |
Chapter 8 Quasispecies Dynamics in Disease Prevention and Control | Abstract Medical interventions to prevent and treat viral disease constitute evolutionary forces that may modify the genetic composition of viral populations that replicate in an infected host, as well as those that expand at the epidemiological level. Strategies intended to minimize vaccination and treatment failures ... |
Herpes zoster might be an indicator for Latent COVID 19 infection | Various cutaneous manifestations have been observed in patients with COVID‐19 infection. Herpes Zoster is a viral skin disease caused by varicella zoster that remains dormant in the dorsal root ganglia of cutaneous nerves following a primary chicken pox infection. In this report we describe two cases COVID infection wh... |
COVID-19: asymptomatic carrier transmission is an underestimated problem | At the present time, COVID-19 is spreading rapidly [1]. The global prevention and control of COVID-19 is focused on the estimation of the relevant incubation period, basic reproduction number (R(0)), effective reproduction number (R(t)) and death risk. Although the prevention and control of COVID-19 requires a reliable... |
A multiplex one-tube nested real time RT-PCR assay for simultaneous detection of respiratory syncytial virus, human rhinovirus and human metapneumovirus | BACKGROUND: Respiratory syncytial virus (RSV), human Rhinovirus (HRV) and human Metapneumo Virus (HMPV) are important viral pathogens causing acute respiratory tract infections in the hospitalized patients. Sensitive and accurate detection of RSV, HRV and HMPV is necessary for clinical diagnosis and treatment. RESULTS:... |
Fluorescent Protein Approaches in Alpha Herpesvirus Research | In the nearly two decades since the popularization of green fluorescent protein (GFP), fluorescent protein-based methodologies have revolutionized molecular and cell biology, allowing us to literally see biological processes as never before. Naturally, this revolution has extended to virology in general, and to the stu... |
How Hubei fought the virus | Doctors on the front line in the Chinese province where the coronavirus outbreak started tell Donna Lu about their experiences treating covid-19 |
Global Surveillance, National Surveillance, and SARS | |
Care of patients with hemoglobin disorders during the COVID‐19 pandemic: An overview of recommendations | |
Australia's international health relations in 2003 | A survey for the year 2003 of significant developments in Australia's official international health relations, and their domestic ramifications, is presented. The discussion is set within the broader context of Australian foreign policy. Sources include official documents, media reports and consultations with officers ... |
Detection of Human Bocavirus mRNA in Respiratory Secretions Correlates with High Viral Load and Concurrent Diarrhea | Human bocavirus (HBoV) is a parvovirus recently identified in association with acute respiratory infections (ARI). Despite its worldwide occurrence, little is known on the pathogenesis of HBoV infections. In addition, few systematic studies of HBoV in ARI have been conducted in Latin America. Therefore, in order to tes... |
Variable 3’polyadenylation of Wheat yellow mosaic virus and its novel effects on translation and replication | BACKGROUND: Polyadenylation influences many aspects of mRNA as well as viral RNA. variable polyadenylation at the 3' end have been reported in RNA viruses. It is interesting to identify the characteristic and potential role of 3' polyadenylation of Wheat yellow mosaic virus (WYMV), which has been reported to contain tw... |
Allergie respiratoire et virus | Summary Viral respiratory tract infections are a major cause of wheezing in infants. Investigators determined that 80% to 85% of school-aged children with wheezing episodes were tested positive for virus. To more fully understand how viral respiratory tract infections influence asthma, investigators have evaluated the ... |
Effect of essential oils on the immune response to some viral vaccines in broiler chickens, with special reference to Newcastle disease virus | Abstract This trial assessed the efficacy of a commercial essential oils (Eos) product on the immune response to vaccination against Newcastle disease (ND) and subsequent challenge with virulent ND virus genotype VII (vNDv genotype VII) by using the following experimental groups of broiler chickens (each group had 21 b... |
Locked-down digital work | Covid-19 and the related lockdown in many countries made digital work no longer just an option, but the new norm for many office workers who began to make sense of a new range of benefits of digital work tools. Based on my own observations and on observations shared by executives in New Zealand and Europe, I illustrate... |
The Oakville Oil Refinery Closure and Its Influence on Local Hospitalizations: A Natural Experiment on Sulfur Dioxide | Background: An oil refinery in Oakville, Canada, closed over 2004–2005, providing an opportunity for a natural experiment to examine the effects on oil refinery-related air pollution and residents’ health. Methods: Environmental and health data were collected for the 16 years around the refinery closure. Toronto (2.5 m... |
Modifications of emergency dental clinic protocols to combat COVID‐19 transmission | During the COVID‐19 pandemic, incidence rates for dental diseases will continue unabated. However, the intent to prevent the spread of this lethal respiratory disease will likely lead to reduced treatment access due to restrictions on population movements. These changes have the potential to increase dental‐related eme... |
The ProTides Boom | The masking of nucleoside phosphate and phosphonate groups by an aryl motif and an amino acid ester, nowadays known as the ‘ProTide’ technology, has proven to be effective in the discovery of nucleotide therapeutics. Indeed, this technology, which was invented by Chris McGuigan in the early 1990s, has inspired the disc... |
SARS‐CoV‐2 containment in complex surgical units during the COVID‐19 pandemic | |
Predictive Data Mining Models for Novel Coronavirus (COVID-19) Infected Patients’ Recovery | Novel coronavirus (COVID-19 or 2019-nCoV) pandemic has neither clinically proven vaccine nor drugs; however, its patients are recovering with the aid of antibiotic medications, anti-viral drugs, and chloroquine as well as vitamin C supplementation. It is now evident that the world needs a speedy and quicker solution to... |
Legal Issues in Quarantine and Isolation for Control of Emerging Infectious Diseases | The Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in South Korea in 2015 has drawn public attention regarding the legal regulation of infectious disease control in Korea. This paper discusses the interpretive and legislative concerns regarding the Infectious Disease Prevention and Control Act, its or... |
CHAPTER 2 Infections, Inflammogens, and Drugs | Publisher Summary This chapter examines environmental inflammatory factors in vascular disease and dementia with a focus on infections, environmental inflammogens, and drugs that modulate both vascular disease and dementia. Infections and blood levels of inflammatory proteins are risk factors for future coronary events... |
Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions | Abstract The coronavirus disease-19 pandemic (COVID-19), which appeared in China in December 2019 and rapidly spread throughout the world, has forced clinicians and scientists to take up extraordinary challenges. This unprecedented situation led to the inception of numerous fundamental research protocols and many clini... |
Two Detailed Plaque Assay Protocols for the Quantification of Infectious SARS‐CoV‐2 | Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) has been identified as the causal agent of COronaVIrus Disease‐19 (COVID‐19), an atypical pneumonia‐like syndrome that emerged in December 2019. While SARS‐CoV‐2 titers can be measured by detection of viral nucleic acid, this method is unable to quantitate in... |
Clinical feedback from experience with COVID-19: specific considerations for ExtraCorporeal Membrane Oxygenation | |
VR systems in dental education | |
Impact of the COVID-19 Pandemic on Neurosurgical Practice at an Academic Tertiary Referral Center: A Comparative Study | Abstract Background Neurosurgical services are affected by the COVID-19 pandemic, and several departments reported their experiences and responses to the COVID-19 crisis in an attempt to provide insights from which other impacted departments can benefit. Objective The goals of this study are to report the load and vari... |
COVID-19 and therapeutic drugs repurposing in hand: the need for collaborative efforts | Abstract The novel pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible to cause coronavirus disease-2019 (COVID-19). It is a global pandemic disease and has reached a new dimension with a higher death ratio. On 2 June 2020, World Health Organization (WHO) data showed more than 6,194,500... |
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