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Modeling the impact of non-pharmaceutical interventions on the dynamics of novel coronavirus with optimal control analysis with a case study | Coronavirus disease (COVID-19) is the biggest public health challenge the world is facing in recent days. Since there is no effective vaccine and treatment for this virus, therefore, the only way to mitigate this infection is the implementation of non-pharmaceutical interventions such as social-distancing, community lo... |
Recommendations of individualized medical treatment and common adverse events management for lung cancer patients during the outbreak of COVID‐19 epidemic | Since its outbreak in December 2019 in China, the novel coronavirus disease (COVID‐19) has rapidly spread and affected several countries. It has resulted in a difficult situation for cancer patients owing to the risks of the epidemic situation outbreak as well as cancer. Patients with cancer are more likely than the ge... |
Slaughterhouses: A major target for COVID-19 prevention | |
A new membrane based process to isolate immunoglobulin from chicken egg yolk | Abstract Although the importance of eggs as a source of specific antibodies has been well recognised, the generation of egg yolk immunoglobulins (IgY) is rarely chosen due to the peculiar composition of egg yolk and the lack of specific affinity ligands. In this work, we report a novel membrane based two-stage ultrafil... |
Knowledge and beliefs towards universal safety precautions during the coronavirus disease (COVID-19) pandemic among the Indian public: a web-based cross-sectional survey | BACKGROUND: The novel coronavirus disease 2019 (COVID-19) is considered the most serious global health threat in recent times. As there is a current lack of approved treatments and vaccines, universal safety precautions (USPs) must be taken to deal with this emergency. OBJECTIVE: The aim of this study was to assess the... |
The Phylogeography of MERS-CoV in Hospital Outbreak-Associated Cases Compared to Sporadic Cases in Saudi Arabia | This study compared the phylogeography of MERS-CoV between hospital outbreak-associated cases and sporadic cases in Saudi Arabia. We collected complete genome sequences from human samples in Saudi Arabia and data on the multiple risk factors of human MERS-CoV in Saudi Arabia reported from 2012 to 2018. By matching each... |
Chapter 5 Upper Airway Infections | Abstract Infections of the upper respiratory tract represent an important source of morbidity and potentially of life-threatening complications. This group of infections represents one of the most frequent outpatient consultations; and includes a range of clinical syndromes that may go from a self-limited common cold, ... |
Chapter 14 Biosecurity Strategies for Backyard Poultry: A Controlled Way for Safe Food Production | Abstract The people of rural and periurban India depend on backyard farming system for poultry meat and eggs. It is used by weaker sections of society, such as marginal farmers as insurance against crop failure, for ready cash and to ensure basic economic returns and the empowerment of women and children. However, back... |
Clinical characteristics and outcome of ICU admitted MERS corona virus infected patients | Abstract Middle East Respiratory Syndrome (MERS) is a novel respiratory illness firstly reported in Saudi Arabia in 2012. It is caused by a new corona virus, called MERS corona virus (MERS-CoV). Most people who have MERS-CoV infection developed severe acute respiratory illness. Aim of the work This work is done to dete... |
Persistent Humoral Immune Responses in the CNS Limit Recovery of Reactivated Murine Cytomegalovirus | BACKGROUND: Experimental infection of the mouse brain with murine CMV (MCMV) elicits neuroimmune responses that terminate acute infection while simultaneously preventing extensive bystander damage. Previous studies have determined that CD8(+) T lymphocytes are required to restrict acute, productive MCMV infection withi... |
Migraine in the Time of COVID‐19 | |
Advanced Pulmonary and Cardiac Support of COVID-19 Patients: Emerging Recommendations From ASAIO—A “Living Working Document” | The severe acute respiratory syndrome (SARS)-CoV-2 is an emerging viral pathogen responsible for the global coronavirus disease 2019 (COVID)-19 pandemic resulting in significant human morbidity and mortality. Based on preliminary clinical reports, hypoxic respiratory failure complicated by acute respiratory distress sy... |
Coronavirus disease‐2019 in pregnancy with neurological manifestations versus pregnancy with eclampsia: Need for liberal testing to rule out the masquerades | We read with interest, the article by Gidlöf et al on the management of a twin pregnancy with severe preeclampsia and Coronavirus disease-2019 (Covid-19) and their call for more liberal testing guidelines in women with high-risk pregnancies, and agree with their suggestion. A severe complication of preeclampsia is ecla... |
Diabetes and COVID‐19: psychosocial consequences of the COVID‐19 pandemic in people with diabetes in Denmark—what characterizes people with high levels of COVID‐19‐related worries? | AIM: To map COVID‐19‐specific worries and overall psychosocial health among people with diabetes in the initial phase of the COVID‐19 pandemic in Denmark, and to explore characteristics of people with diabetes and high levels of worries related to the COVID‐19 pandemic. METHODS: A cross‐sectional survey was conducted b... |
Digital work and organisational transformation: Emergent digital/human work configurations in modern organisations | Abstract Workplace technologies are more central to working in organisations than ever before. These technologies began as instrumental aids to support office work of individuals but have since also become the basis for social interactions and community building in organisations and more recently become able to perform... |
Detection of porcine circovirus genotypes 2a and 2b in aborted foetuses from infected swine herds in the State of São Paulo, Brazil | BACKGROUND: Porcine circovirus type 2 (PCV2) has been associated with several disease complexes, including reproductive failure. The aim of this study was to identify the subtypes of PCV2 that are associated with reproductive failure in pigs from the State of São Paulo, Brazil and to investigate co-infections with othe... |
MicroRNA-155 enhances T cell trafficking and antiviral effector function in a model of coronavirus-induced neurologic disease | BACKGROUND: MicroRNAs (miRNAs) are noncoding RNAs that modulate cellular gene expression, primarily at the post-transcriptional level. We sought to examine the functional role of miR-155 in a model of viral-induced neuroinflammation. METHODS: Acute encephalomyelitis and immune-mediated demyelination were induced by int... |
Screening of Feral and Wood Pigeons for Viruses Harbouring a Conserved Mobile Viral Element: Characterization of Novel Astroviruses and Picornaviruses | A highly conserved RNA-motif of yet unknown function, called stem-loop-2-like motif (s2m), has been identified in the 3′ end of the genomes of viruses belonging to different RNA virus families which infect a broad range of mammal and bird species, including Astroviridae, Picornaviridae, Coronaviridae and Caliciviridae.... |
Clinical course of patients infected with SARS-CoV-2 soon after thoracoscopic lung surgery | |
Male preponderance of COVID‐19 risk | In this editorial, Roger Kirby, Editor‐in‐Chief on Trends in Urology and Men's Health, discusses the discusses the male preponderance of the COVID‐19 mortality risk. |
How do we recover from COVID‐19? Helping diabetes teams foresee and prepare for the psychological harms | The scale of the COVID‐19 pandemic is entirely unprecedented. However, as depicted in Fig. 1, evidence from previous large‐scale disasters indicates that following a first wave of admissions and deaths from COVID‐19, there are likely to be subsequent waves of people with acute care needs worsened by delayed hospital tr... |
Cardiological society of India position statement on COVID-19 and heart failure | The COVID 19 global pandemic has engulfed humanity with a huge impact on health systems across the world. Many patients develop myocardial injury which can lead to significant cardiovascular complications including HF. This will require aggressive management strategies which are evolving. Guideline directed drug therap... |
Intubation and Ventilation amid the COVID-19 Outbreak: Wuhan’s Experience | The COVID-19 outbreak has led to 80,409 diagnosed cases and 3,012 deaths in mainland China based on the data released on March 4, 2020. Approximately 3.2% of patients with COVID-19 required intubation and invasive ventilation at some point in the disease course. Providing best practices regarding intubation and ventila... |
Genomic Sequences of two Novel Levivirus Single-Stranded RNA Coliphages (Family Leviviridae): Evidence for Recombinationin Environmental Strains | Bacteriophages are likely the most abundant entities in the aquatic environment, yet knowledge of their ecology is limited. During a fecal source-tracking study, two genetically novel Leviviridae strains were discovered. Although the novel strains were isolated from coastal waters 1130 km apart (North Carolina and Rhod... |
Community's compliance with measures for the prevention of respiratory infections in Riyadh, Saudi Arabia | BACKGROUND: Acute respiratory tract infections are the most common causes of both morbidity and mortality worldwid, and the management and prevention of acute respiratory infections is a global problem, especially in developing countries. This study sought to assess the community's compliance and practice of measures f... |
Recommandations de la Société Française de Médecine du Travail (SFMT) : Avis relatif à l’affectation, dans le contexte de l’épidémie SARS-CoV-2 (Covid-19), des professionnels exerçant en milieu de soins et travailleurs assimilés, présentant une pathologie chronique traitée par anti-inflammatoires no | |
El SRAA y el SARS-CoV-2: el acertijo a resolver | Resumen El 31 de diciembre de 2019 se reportó el primer caso de COVID-19 en Wuhan, China, y desde entonces ha habido un interés creciente y sin precedentes por conocer todos los aspectos vinculados con esta nueva enfermedad. Uno de los temas que ha generado debate se vincula con la asociación entre la terapia antihiper... |
Point-of-Care Diagnostic Services as an Integral Part of Health Services during the Novel Coronavirus 2019 Era | Point-of-care (POC) diagnostic services are commonly associated with pathology laboratory services This issue presents a holistic approach to POC diagnostics services from a variety of disciplines including pathology, radiological and information technology as well as mobile technology and artificial intelligence This ... |
Chronic cutaneous ulcers management in dermatologic department during COVID‐19 era | |
How to “Detronize” Virus in Crown – Questions to Current Stem Cell Therapies | |
RETRACTED: Autoadaptive ER-Associated Degradation Defines a Preemptive Unfolded Protein Response Pathway | This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the authors. The study reported that expression of misfolded proteins in the ER affects the composition and stability of the dislocation ... |
Nurses' Working Conditions: Implications for Infectious Disease | Poor working conditions are associated with risk for occupational infections. |
Detection of coronavirus RNA and antigen in multiple sclerosis brain | Epidemiological studies of patients with multiple sclerosis (MS) and animal model data support the hypothesis that viruses initiate the immunopathogenic events leading to demyelination in MS. There have been no reports, however, of consistent detection of viruses in MS central nervous system tissue. We probed MS and co... |
Giardiosis and other enteropathogenic infections: a study on diarrhoeic calves in Southern Germany | BACKGROUND: Diarrhoea induces massive problems in the rearing of calves. The aim of the study was to obtain current data about the frequency of Giardia spp., Cryptosporidium spp. and Eimeria spp. in diarrhoeic calves in Southern Germany with the particular focus on giardiosis. RESULTS: 1564 samples were analysed for th... |
La Società Italiana di Endocrinologia (SIE) e l’epidemia COVID-19 | |
Innovation During COVID-19: Improving Addiction Treatment Access | During the COVID-19 pandemic, many addiction treatment and harm reduction organizations have had to reduce their hours and services for people with substance use disorders, placing these individuals at increased risk of death. In order to address restricted treatment access during COVID-19, guidance from the Substance ... |
Managing Cardiac Implantable Electronic Device Patients during a Health Care Crisis: Practical Guidance | Abstract Our world is faced with a global pandemic that threatens to overwhelm many national health care systems for a prolonged period. Consequently, the elective long-term CIED management of millions of patients is potentially compromised raising the likelihood of patients experiencing major adverse events due to los... |
A comprehensive in silico analysis of non-synonymous and regulatory SNPs of human MBL2 gene | Mannose binding lectin (MBL) is a liver derived protein which plays an important role in innate immunity. Mannose binding lectin gene 2 (MBL2) polymorphisms are reported to be associated with various diseases. In spite of being exhaustively studied molecule, no attempt has been made till date to comprehensively and sys... |
Experience of Clinical Management for Pregnant Women and Newborns with Novel Coronavirus Pneumonia in Tongji Hospital, China | Based on the New Diagnosis and Treatment Scheme for Novel Coronavirus Infected Pneumonia (Trial Edition 5), combined with our current clinical treatment experience, we recently proposed a revision of the first edition of “Guidance for maternal and fetal management during pneumonia epidemics of novel coronavirus infecti... |
Tourism expansion and economic development: The case of Taiwan | This study examines the causal relationship between tourism expansion and economic development in Taiwan. A Granger causality test is performed following the cointegration approach to reveal the direction of causality between economic growth and tourism expansion. Test results indicate a long-run equilibrium relationsh... |
Infection of SARS-CoV on juvenile and adult Brandt’s voleMicrotus brandtii | We studied the infectious effect of SARS-CoV virus on juvenile and adult Brandt’s Vole (Microtus brandtii) by nasal cavity spraying method (CCID(50) is 10(5.7)). SARS virus caused serious deaths in adults. The death adults demonstrated hemorrhage from mouth, nasal cavity and intestine, hemorrhageious interstitial pneum... |
Empower Women in Healthcare to move Women’s Health forward | Abstract Medical science and patient care have historically focused on male patients. Many diagnoses in women are still undetermined and it takes several years longer to establish comparable diagnoses in women as in men. Women live longer and have more unhealthy years with ageing than men. Sociocultural aspects vary im... |
Risk factors and dynamics of household transmission of respiratory syncytial virus and other respiratory viruses in rural Nepal | |
Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants | The recent Middle East respiratory syndrome coronavirus (MERS-CoV), Ebola and Zika virus outbreaks exemplify the continued threat of (re-)emerging viruses to human health, and our inability to rapidly develop effective therapeutic countermeasures. Many viruses, including MERS-CoV and the Crimean-Congo hemorrhagic fever... |
Circulation of pantropic canine coronavirus in autochthonous and imported dogs, Italy | Canine coronavirus (CCoV) strains with the ability to spread to internal organs, also known as pantropic CCoVs (pCCoVs), have been detected in domestic dogs and wild carnivores. Our study focused on the detection and molecular characterization of pCCoV strains circulating in Italy during the period 2014–2017 in autocht... |
What works and what does not work in response to COVID-19 prevention and control in Africa | Abstract Since the emergence of the pandemic in December 2019 in Wuhan, China, as of 10:00 CEST, June 6, 2020, there have been nearly 6,663,304 confirmed cases of COVID-19 including 392,802 deaths worldwide. In Africa, as of June 2, 2020, a total of 152,442 COVID-19 cases and 4334 deaths have been reported. The five co... |
Detection of Severe Acute Respiratory Syndrome Coronavirus in the Brain: Potential Role of the Chemokine Mig in Pathogenesis | Background. Previous studies have shown that common human coronavirus might be neurotropic, although it was first isolated as a pathogen of the respiratory tract. We noticed that a few patients with severe acute respiratory syndrome (SARS) experienced central nervous symptoms during the course of illness. In the presen... |
Interfering antiviral immunity: application, subversion, hope? | RNA interference (RNAi), initially recognized as a natural antiviral mechanism in plants, has rapidly emerged as an invaluable tool to suppress gene expression in a sequence-specific manner in all organisms, including mammals. Its potential to inhibit the replication of a variety of viruses has been demonstrated in vit... |
Optimal media reporting intensity on mitigating spread of an emerging infectious disease | Mass media reports can induce individual behaviour change during a disease outbreak, which has been found to be useful as it reduces the force of infection. We propose a compartmental model by including a new compartment of the intensity of the media reports, which extends existing models by considering a novel media f... |
Antiviral therapies targeting host ER alpha-glucosidases: Current status and future directions | Abstract Endoplasmic reticulum (ER)-resident α-glucosidases I and II sequentially trim the three terminal glucose moieties on N-linked glycans attached to nascent glycoproteins. These reactions are the first steps of N-linked glycan processing and are essential for proper folding and function of many glycoproteins. Bec... |
Health Care Worker Contact with MERS Patient, Saudi Arabia | To investigate potential transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) to health care workers in a hospital, we serologically tested hospital contacts of the index case-patient in Saudi Arabia, 4 months after his death. None of the 48 contacts showed evidence of MERS-CoV infection. |
Moving towards a new vision: implementation of a public health policy intervention | BACKGROUND: Public health systems in Canada have undergone significant policy renewal over the last decade in response to threats to the public’s health, such as severe acute respiratory syndrome. There is limited research on how public health policies have been implemented or what has influenced their implementation. ... |
Ebola Virus Disease Epidemic: What Can the World Learn and Not Learn from West Africa? | With over 4,500 deaths and counting, and new cases identified in two developed countries that are struggling and faltering in their handling of the epidemic, the 2014 Ebola Virus Disease (EVD) epidemic is unlike any of its kind ever encountered. The ability of some poor, resource-limited, developing countries in sub-Sa... |
The Perfect Moral Storm: Diverse Ethical Considerations in the COVID-19 Pandemic | The COVID-19 pandemic has both exposed and created deep rifts in society. It has thrust us into deep ethical thinking to help justify the difficult decisions many will be called upon to make and to protect from decisions that lack ethical underpinnings. This paper aims to highlight ethical issues in six different areas... |
The Orthopaedic Trauma Service and COVID-19: Practice Considerations to Optimize Outcomes and Limit Exposure | |
COVID-19: Are we dealing with a multisystem vasculopathy in disguise of a viral infection? | After the emergence of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in the last two decades, the world is facing its new challenge in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic with unprecedented global response. With the... |
Prenatal and childhood infections: implications for the development and treatment of childhood asthma | Summary Bacterial and viral infections occur early and recurrently in life and thereby impose a substantial disease burden. Besides causing clinical symptoms, a potential role of infection in the development of the asthma syndrome later in life has also been suggested. However, whether bacterial and viral infections un... |
The challenges of remote working | The exhortation to stay at home to comply with the current legal requirement for social distancing has put the delivery of healthcare services in an unusual position The Healthcare Protection (Coronavirus Restrictions) Regulations 2020, resulted in the closure of restaurants and pubs along with the limitation on indivi... |
Development of a standard treatment protocol for severe acute respiratory syndrome | Summary A series of 31 patients with probable SARS, diagnosed from WHO criteria, were treated according to a treatment protocol consisting of antibacterials and a combination of ribavirin and methylprednisolone. Through experience with the first 11 patients, we were able to finalise standard dose regimens, including pu... |
SARS in Healthcare Facilities, Toronto and Taiwan | The healthcare setting was important in the early spread of severe acute respiratory syndrome (SARS) in both Toronto and Taiwan. Healthcare workers, patients, and visitors were at increased risk for infection. Nonetheless, the ability of individual SARS patients to transmit disease was quite variable. Unrecognized SARS... |
Insufficient preparedness of primary care practices for pandemic influenza and the effect of a preparedness plan in Japan: a prefecture-wide cross-sectional study | BACKGROUND: Cases of emerging infectious diseases, including H5N1 influenza, H7N9 influenza, and Middle East Respiratory Syndrome, have been reported in recent years, and the threat of pandemic outbreaks persists. In Japan, primary care is the frontline against emerging infectious diseases in communities. Although the ... |
Chapter 6 Epidemiology and Control of Viral Diseases | Publisher Summary Epidemiology is the study of the determinants, dynamics, and distribution of diseases in populations. The risk of infection and disease in an animal or animal population is determined by characteristics of the virus, the host and host population, and behavioral, environmental, and ecological factors t... |
Co-infection of MERS-CoV and SARS-CoV-2 in the same host: a silent threat | |
Encephalitis diagnosis using metagenomics: application of next generation sequencing for undiagnosed cases | Abstract Background Current estimates suggest that even in the most resourced settings, the aetiology of encephalitis is identified in less than half of clinical cases. It is acknowledged that filling this gap needs a combination of rigorous sampling and improved diagnostic technologies. Next generation sequencing (NGS... |
Molecular epidemiology of bovine noroviruses in South Korea | Abstract Since the prevalence of bovine norovirus (BNoV) and their genetic diversity have only been reported in the USA, England, Germany and The Netherlands, this study examined the prevalence and genetic diversity of BNoVs in diarrheic calves in South Korea using 645 diarrheic fecal specimens from calves by RT-PCR an... |
Phylogenic analysis of human bocavirus detected in children with acute respiratory infection in Yaounde, Cameroon | OBJECTIVE: Human Bocavirus (HBoV) was first identified in 2005 and has been shown to be a common cause of respiratory infections and gastroenteritis in children. In a recent study, we found that 10.7% of children with acute respiratory infections (ARI) were infected by HBoV. Genetic characterization of this virus remai... |
The Petri-Dish Effect | |
Efficacy and immunogenicity of recombinant swinepox virus expressing the A epitope of the TGEV S protein | Abstract To explore the possibility of developing a vaccine against transmissible gastroenteritis virus (TGEV) infection, a recombinant swinepox virus (rSPV-SA) expressing a TGEV protective antigen has been constructed. Immune responses and protection efficacy of the vaccination vector were assessed in both mice and pi... |
Critical COPD respiratory illness is linked to increased transcriptomic activity of neutrophil proteases genes | BACKGROUND: Gene expression profiling (GEP) in cells obtained from peripheral blood has shown that this is a very useful approach for biomarker discovery and for studying molecular pathogenesis of prevalent diseases. While there is limited literature available on gene expression markers associated with Chronic Obstruct... |
Pandemic March: 2019 Coronavirus Disease’s First Wave Circumnavigates the Globe | OBJECTIVE: March 2020 was a pivotal month for the worldwide geographic and numeric expansion of the first wave of Coronavirus Disease 2019 (COVID-19). We examined the major storylines that depicted this explosive spread of COVID-19 around the globe. METHODS: A detailed review of World Health Organization (WHO) situatio... |
State of Knowledge and Data Gaps of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Humans | Background: Between September 2012 and 22 October 2013, 144 laboratory-confirmed and 17 probable MERS-CoV cases from nine countries were notified to WHO. Methods: We summarize what is known about the epidemiology, virology, phylogeny and emergence of MERS-CoV to inform public health policies. Results: The median age of... |
A survey of the preparedness for an influenza pandemic of general practitioners in the West Midlands, UK | There is a lack of evidence regarding the preparedness of general practitioners (GPs) to respond to pandemic influenza. A postal questionnaire survey was conducted to explore the self-perceived pandemic preparedness of GPs in the West Midlands, United Kingdom, and to determine differences between urban and non-urban GP... |
Effectiveness of Common Fabrics to Block Aqueous Aerosols of Virus-like Nanoparticles | [Image: see text] Layered systems of commonly available fabric materials can be used by the public and healthcare providers in face masks to reduce the risk of inhaling viruses with protection that is about equivalent to or better than the filtration and adsorption offered by 5-layer N95 respirators. Over 70 different ... |
Between Fear and Courage: Attitudes, Beliefs, and Behavior of Liver Transplantation Recipients and Waiting List Candidates during the COVID‐19 Pandemic | Patients with chronic liver disease and patients after solid organ transplantation (SOT) are vulnerable to severe Coronavirus Disease 2019 (COVID‐19). We evaluated fears, attitudes, and opinions associated with COVID‐19 in 365 SOT recipients (95% liver, 5% pancreas/kidney), 112 SOT candidates, and 394 immediate househo... |
The Pan London Emergency Cardiac Surgery service: Coordinating a response to the COVID‐19 pandemic | Over the last 4 months, the novel coronavirus, SARS‐CoV‐2, has caused a significant economic, political, and public health impact on a global scale. The natural history of the disease and surge in the need for invasive ventilation has required the provision of intensive care beds in London to be reallocated. NHS Englan... |
Inhibitors of Deubiquitinating Enzymes Block HIV-1 Replication and Augment the Presentation of Gag-Derived MHC-I Epitopes | In recent years it has been well established that two major constituent parts of the ubiquitin proteasome system (UPS)—the proteasome holoenzymes and a number of ubiquitin ligases—play a crucial role, not only in virus replication but also in the regulation of the immunogenicity of human immunodeficiency virus type 1 (... |
Reliable and Standardized Animal Models to Study the Pathogenesis of Bluetongue and Schmallenberg Viruses in Ruminant Natural Host Species with Special Emphasis on Placental Crossing | Starting in 2006, bluetongue virus serotype 8 (BTV8) was responsible for a major epizootic in Western and Northern Europe. The magnitude and spread of the disease were surprisingly high and the control of BTV improved significantly with the marketing of BTV8 inactivated vaccines in 2008. During late summer of 2011, a f... |
COVID-19 Illness and Heart Failure A Missing Link? | |
The Effect of 13-Valent Pneumococcal Conjugate Vaccine on the Serotype Distribution and Antibiotic Resistance Profiles in Children With Invasive Pneumococcal Disease | BACKGROUND: Invasive pneumococcal disease (IPD) continues to be a significant burden in children despite the implementation of two generations of conjugate vaccines. Serotype replacement by nonvaccine serotypes is reported in multiple areas around the world. This study is a continuation of previous studies and describe... |
CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV) | In this retrospective case series, chest CT scans of 21 symptomatic patients from China infected with the 2019 novel coronavirus (2019-nCoV) were reviewed, with emphasis on identifying and characterizing the most common findings. Typical CT findings included bilateral pulmonary parenchymal ground-glass and consolidativ... |
Development of allergy in children I. Association with virus infections | Abstract Children born into allergic families, with two allergic parents, are at high risk of developing allergy within the first 5 years of life. In order to observe possible external factors in the sensitization process, a prospective study of 13 such children was done, in which serial clinical and immunologic observ... |
Cardiac dysfunction and shock in pediatric patients with COVID-19 | Abstract The 2019 novel coronavirus (COVID-19) has been reported to cause significant morbidity in adults with reportedly a lesser impact on children. Cardiac dysfunction has only been described in adults thus far. We describe three cases of previously healthy children presenting with shock and COVID-19 related cardiac... |
Pandemic Influenza: A Potential Role for Statins in Treatment and Prophylaxis | The next influenza pandemic may be imminent. Because antiviral agents and vaccines will be unavailable to people in most countries, we need to determine whether other agents could offer clinical benefits. Influenza is associated with an increase in acute cardiovascular diseases, and influenza viruses induce proinflamma... |
Viral Protease Inhibitors | This review provides an overview of the development of viral protease inhibitors as antiviral drugs. We concentrate on HIV-1 protease inhibitors, as these have made the most significant advances in the recent past. Thus, we discuss the biochemistry of HIV-1 protease, inhibitor development, clinical use of inhibitors, a... |
How Did COVID-19 Affect Firms’ Access to Public Capital Markets? | We find that bond issues have substantially increased since the onset of the COVID-19 crisis in calendar week 12 (March 16–20) for bonds rated A or higher, but surprisingly also for bonds rated BBB or lower. In contrast to existing evidence on bond maturities in economic downturns, we document that maturities exceed th... |
Hajj, Umrah, and the neglected tropical diseases | |
Comparative evaluation of a laboratory-developed real-time PCR assay and RealStar® Adenovirus PCR Kit for quantitative detection of human adenovirus | BACKGROUND: Human adenoviruses are common causes of community-acquired respiratory tract and enteric infections. Severe disseminated infections with high mortality rates may be seen in immunocompromised individuals. An accurate and cost-effective quantitative assay is essential not only for laboratory diagnosis of aden... |
Cyclophilin–CD147 interactions: a new target for anti-inflammatory therapeutics | CD147 is a widely expressed plasma membrane protein that has been implicated in a variety of physiological and pathological activities. It is best known for its ability to function as extracellular matrix metalloproteinase inducer (hence the other name for this protein, EMMPRIN), but has also been shown to regulate lym... |
The Location of the Protonated and Unprotonated Forms of Arbidol in the Membrane: A Molecular Dynamics Study | ABSTRACT: Arbidol is a potent broad-spectrum antiviral molecule for the treatment and prophylaxis of many viral infections. Viruses that can be inhibited by arbidol include enveloped and non-enveloped viruses, RNA and DNA viruses, as well as pH-independent and pH-dependent ones. These differences in viral types highlig... |
Climate change impact on migration, travel, travel destinations and the tourism industry | Background: Climate change is not only increasing ambient temperature but also accelerating the frequency, duration and intensity of extreme weather and climate events, such as heavy precipitation and droughts, and causing sea level rise, which can lead to population displacement. Climate change-related reductions in l... |
Co-infection cases of human common respiratory viruses in Beijing, 2010–2012 | |
Combining Free Text and Structured Electronic Medical Record Entries to Detect Acute Respiratory Infections | BACKGROUND: The electronic medical record (EMR) contains a rich source of information that could be harnessed for epidemic surveillance. We asked if structured EMR data could be coupled with computerized processing of free-text clinical entries to enhance detection of acute respiratory infections (ARI). METHODOLOGY: A ... |
Laparoscopic Major Hepatectomy—Technique and Outcomes | BACKGROUND: With technological innovations especially newer parenchymal transection devices, improved understanding of hepatic anatomy facilitated by better imaging, and reconstructions along with experiences gained from advanced minimal invasive procedures, laparoscopic liver surgery is gaining momentum with more than... |
Effect of deoxycholate, amphotericin B and fongizone on transmissible gastroenteritis coronavirus | Summary At a concentration of 2 μg/ml, neither amphotericin B nor deoxycholate had an inactivating effect upon transmissible gastroenteritis Coronavirus in-fectivity. However, amphothericin B stimulated plaque formatin in agarose and facilitated the entry of viral RNA into swine testis cells. The combination of amphote... |
CHEST Reviews: Addressing reduced laboratory-based pulmonary function testing during a pandemic | Abstract To reduce the spread of SARS-CoV-2, many pulmonary function testing (PFT) laboratories have been closed or have significantly reduced their testing capacity. As these mitigation strategies may be necessary for the next 6-18 months to prevent recurrent peaks in disease prevalence, fewer objective measurements o... |
Haunted with and hunting for viruses | |
Pneumonia caused by Mycobacterium tuberculosis | Tuberculosis (TB) is one of the top ten leading causes of death worldwide. The causative agent of TB is Mycobacterium tuberculosis. Acute tuberculous pneumonia (TP) is an acute form of pulmonary TB. However, acute TP and non-tuberculous community-acquired pneumonia can be easily confused, resulting in deterioration of ... |
L’exposition d’un nourrisson à un chien n’augmente pas le risque de sensibilisation ; elle semble même diminuer les risques de sensibilisation à d’autres pneumallergènes et le risque d’asthme à 4 ans ! C. | Unknown |
Differential neurodegenerative phenotypes are associated with heterogeneous voiding dysfunction in a coronavirus-induced model of multiple sclerosis | Patients with multiple sclerosis (MS) develop a variety of lower urinary tract symptoms (LUTS). We previously characterized a murine model of neurogenic bladder dysfunction induced by a neurotropic strain of a coronavirus. In the present study, we further study the role of long-lasting neurodegeneration on the developm... |
Community-Based Assessment of Knowledge, Attitude, Practices and Risk Factors Regarding COVID-19 Among Pakistanis Residents During a Recent Outbreak: A Cross-Sectional Survey | Exceptional precautionary measures have been adopted to stop the transmission and control of COVID-19 through the world and Pakistan is facing lockdown in this scenario. Public loyalty to precautionary measures is affected by their knowledge, attitude, risk factors and practices (KAP) towards COVID-19. The present stud... |
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