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Problematic Internet Use and Perceived Quality of Life: Findings from a Cross-Sectional Study Investigating Work-Time and Leisure-Time Internet Use | Avoiding the potential negative impact brought by problematic internet use is becoming more important. To better understand public health and addiction, this study investigated to what extent work-time and leisure-time internet use relate to problematic internet use and perceived quality of life among college students ... |
Clinical Distancing of Hospitalized Patients with Advanced Heart Failure and Cardiac Transplantation During COVID-19 | |
Use of Face Masks in Dermatology Department During the COVID‐19 Outbreak | |
Asymptomatic and presymptomatic transmission of SARS-CoV-2: A systematic review | BACKGROUND AND PURPOSE: Many of the statutes comprising the shelter-in-place and phased-reopening orders are centered around minimizing asymptomatic and presymptomatic transmission. Assumptions about the presence and relative importance of asymptomatic and presymptomatic transmission are based on case reports, the fail... |
Intellectual and Developmental Disability and COVID-19 Case-Fatality Trends: TriNetX Analysis | BACKGROUND: Despite possibly higher risk of severe outcomes from COVID-19 among people with intellectual and developmental disabilities (IDD), there has been limited reporting of COVID-19 trends for this population. OBJECTIVE: To compare COVID-19 trends among people with and without IDD, overall and stratified by age. ... |
Comment on “Organ‐protective effect of angiotensin‐converting enzyme 2 and its effect on the prognosis of COVID‐19” | I read with this informative review article by Cheng et al. “ Organ‐protective effect of angiotensin‐converting enzyme 2 and its effect on the prognosis of COVID‐19”. I would like to talk about the role of ACE2 in endothelial cell function. Besides, I would like to mention that COVID‐19 patients might benefit from ACEI... |
Recent advances in “universal” influenza virus antibodies: the rise of a hidden trimeric interface in hemagglutinin globular head | Influenza causes seasonal outbreaks yearly and unpredictable pandemics with high morbidity and mortality rates. Despite significant efforts to address influenza, it remains a major threat to human public health. This issue is partially due to the lack of antiviral drugs with potent antiviral activity and broad reactivi... |
COVID‐19 and obesity | |
Molecular approaches in the diagnosis of primary immunodeficiency diseases | Over 120 inherited primary immunodeficiency diseases (PIDs) are known to exist. The genes responsible for many of these diseases have also been identified. Recent advances in diagnostic procedures have enabled these to be identified earlier and appropriately treated. While a number of approaches are available to identi... |
Effect of Chloroquine, Hydroxychloroquine, and Azithromycin on the Corrected QT Interval in Patients With SARS-CoV-2 Infection | The novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is responsible for the global coronavirus disease 2019 pandemic. Small studies have shown a potential benefit of chloroquine/hydroxychloroquine±azithromycin for the treatment of coronavirus disease 2019. Use of these medications alone, or in combina... |
Replacement Management in Cattle | Breeding Standards and Pregnancy Management | Rearing replacement heifers is part of herd survivability and represents 15–20% of total farm costs. Proper attention to the growth of heifers is paramount to producing heifers that achieve adequate stature and body weight before first breeding and calving. Timely entry of heifers into the milking herd by 2 years of ag... |
Rapid and severe Covid‐19 pneumonia with severe acute chest syndrome in a sickle cell patient successfully treated with tocilizumab | |
Analysis of the complete genomic sequences of two virus subpopulations of the Australian infectious bronchitis virus vaccine VicS | Although sequencing of the 3′ end of the genome of Australian infectious bronchitis viruses (IBVs) has shown that their structural genes are distinct from those of IBVs found in other countries, their replicase genes have not been analysed. To examine this, the complete genomic sequences of the two subpopulations of th... |
Collateral effects of COVID‐19 pandemic in pediatric hematooncology: Fatalities caused by diagnostic delay | |
Incidence, significance, and persistence of human coronavirus infection in hematopoietic stem cell transplant recipients | Hematopoietic stem cell transplant (HSCT) recipients are at increased risk of respiratory viral infections and their associated complications. Unlike other respiratory viruses, little is known about the clinical significance of human coronavirus infection (HCoV) in this population. We retrospectively identified all HSC... |
Elevated N-terminal pro-brain natriuretic peptide is associated with increased mortality in patients with COVID-19: systematic review and meta-analysis | OBJECTIVES: This systematic review and meta-analysis aimed to assess the association between N-terminal pro-brain natriuretic peptide (NT-proBNP) and mortality in patients with COVID-19. METHODS: Systematic literature search from several electronic databases were performed. The outcome was mortality (non-survivor) in p... |
Genomic Dissection of an Icelandic Epidemic of Respiratory Disease in Horses and Associated Zoonotic Cases | Iceland is free of the major infectious diseases of horses. However, in 2010 an epidemic of respiratory disease of unknown cause spread through the country’s native horse population of 77,000. Microbiological investigations ruled out known viral agents but identified the opportunistic pathogen Streptococcus equi subsp.... |
Genetic dissection of host immune response in pneumonia development and progression | The role of host genetic variation in pneumonia development and outcome is poorly understood. We studied common polymorphisms in the genes of proinflammatory cytokines (IL6 rs1800795, IL8 rs4073, IL1B rs16944), anti-inflammatory cytokines (IL10 rs1800896, IL4 rs2243250, IL13 rs20541) and toll-like receptors (TLR2 rs574... |
Phylogeny of SARS-CoV as inferred from complete genome comparison | SARS-CoV, as the pathogeny of severe acute respiratory syndrome (SARS), is a mystery that the origin of the virus is still unknown even a few isolates of the virus were completely sequenced. To explore the genesis of SARS-CoV, the FDOD method previously developed by us was applied to comparing complete genomes from 12 ... |
The persistence of multiple strains of avian influenza in live bird markets | Multiple subtypes of avian influenza (AI) and novel reassortants are frequently isolated from live bird markets (LBMs). However, our understanding of the drivers of persistence of multiple AI subtypes is limited. We propose a stochastic model of AI transmission within an LBM that incorporates market size, turnover rate... |
Identification of Novel Rosavirus Species That Infects Diverse Rodent Species and Causes Multisystemic Dissemination in Mouse Model | While novel picornaviruses are being discovered in rodents, their host range and pathogenicity are largely unknown. We identified two novel picornaviruses, rosavirus B from the street rat, Norway rat, and rosavirus C from five different wild rat species (chestnut spiny rat, greater bandicoot rat, Indochinese forest rat... |
Hospitality unionism and labour market adjustment: Toward Schumpeterian unionism? | Abstract This paper proposes a conceptual model for understanding emerging changes in a North American labour union. UNITE-HERE, largely representing textile and hospitality workers, has been at the forefront of debates on union revitalization in the US and Canada. UNITE-HERE is often characterized as a successful exam... |
Go slow to go fast: A plea for sustained scientific rigor in air pollution research during the COVID-19 pandemic | Present studies on the role of air pollution and COVID-19 spread and prognosis in patients do not fulfill quality criteria and are at present not sufficiently informative. |
Molecular and serological surveillance of canine enteric viruses in stray dogs from Vila do Maio, Cape Verde | BACKGROUND: Infections caused by canine parvovirus, canine distemper virus and canine coronavirus are an important cause of mortality and morbidity in dogs worldwide. Prior to this study, no information was available concerning the incidence and prevalence of these viruses in Cape Verde archipelago. RESULTS: To provide... |
The impact of COVID‐19 pandemic on ophthalmological emergency department visits | |
Ibuprofen and thromboembolism in SARS‐COV2 | Recent and developing literature has begun reporting on the incidence of thromboembolic events associated with COVID‐19. Klok et al. analysed 184 SARS‐CoV2‐positive ICU patients in two Dutch University Hospitals, reporting an incidence of thrombotic complications to be 31%, with Pulmonary Embolism (PE) comprising 81% o... |
Covid-19 and community development | |
Virus‐like particules in the poison glant of the parasitic wasp Opius concolor | Virus‐like particles (VLP's) have been found in the poison glands of adult females of the parasitic wasp Opius concolor Szèpl. (Hymenoptera, Braconidae). These VLP's are found in the secretory cells either free in the cytoplasm or within cytoplasmic vesicles, sometimes associated to a secretory apparatus. Negative stai... |
Rapid implementation of virtual clinics due to COVID-19: report and early evaluation of a quality improvement initiative | BACKGROUND: The COVID-19 outbreak has placed the National Health Service under significant strain. Social distancing measures were introduced in the UK in March 2020 and virtual consultations (via telephone or video call) were identified as a potential alternative to face-to-face consultations at this time. LOCAL PROBL... |
Livestock Drugs and Disease: The Fatal Combination behind Breeding Failure in Endangered Bearded Vultures | There is increasing concern about the impact of veterinary drugs and livestock pathogens as factors damaging wildlife health, especially of threatened avian scavengers feeding upon medicated livestock carcasses. We conducted a comprehensive study of failed eggs and dead nestlings in bearded vultures (Gypaetus barbatus)... |
Who should perform the rhinopharyngeal swab in COVID‐19 positive patients? | |
Origin, Adaptation and Evolutionary Pathways of Fungal Viruses | Fungal viruses or mycoviruses are widespread in fungi and are believed to be of ancient origin. They have evolved in concert with their hosts and are usually associated with symptomless infections. Mycoviruses are transmitted intracellularly during cell division, sporogenesis and cell fusion, and they lack an extracell... |
Postoperative online follow-up improves the quality of life of patients who undergo extraction of impacted madibular third molars: a randomized controlled trial | OBJECTIVE: To evaluate the effect of online follow-up on the quality of life of patients who undergo extraction of impacted mandibular third molars. MATERIALS AND METHODS: This study enrolled patients with impacted mandibular third molars who were treated at the Department of Oral and Maxillofacial Surgery of the Stoma... |
Recombination in Avian Gamma-Coronavirus Infectious Bronchitis Virus | Recombination in the family Coronaviridae has been well documented and is thought to be a contributing factor in the emergence and evolution of different coronaviral genotypes as well as different species of coronavirus. However, there are limited data available on the frequency and extent of recombination in coronavir... |
Temporal Variation in Physiological Biomarkers in Black Flying-Foxes (Pteropus alecto), Australia | Bats of the genus Pteropus (Pteropodidae) are recognised as the natural host of multiple emerging pathogenic viruses of animal and human health significance, including henipaviruses, lyssaviruses and ebolaviruses. Some studies have suggested that physiological and ecological factors may be associated with Hendra virus ... |
Emergence of Enteric Viruses in Production Chickens Is a Concern for Avian Health | Several viruses have been identified in recent years in the intestinal contents of chickens and turkeys with enteric problems, which have been observed in commercial farms worldwide, including Brazil. Molecular detection of these viruses in Brazil can transform to a big threat for poultry production due to risk for int... |
Pulling a DNA molecule through a nanopore embedded in an anionic membrane: tension propagation coupled to electrostatics | We consider the influence of electrostatic forces on driven translocation dynamics of a flexible polyelectrolyte being pulled through a nanopore by an external force on the head monomer. To this end, we augment the iso-flux tension propagation (IFTP) theory with electrostatics for a negatively charged biopolymer pulled... |
An advanced numerical model for the assessment of airborne transmission of influenza in bus microenvironments | Abstract A CFD-based numerical model was integrated with the Wells–Riley equation to numerically assess the risk of airborne influenza infection in a popular means of public transportation, e.g. the bus microenvironment. Three mixing ventilation methods, which are widely used in current bus configurations, and an alter... |
Candidate drugs against SARS-CoV-2 and COVID-19 | Abstract Outbreak and pandemic of coronavirus SARS-CoV-2 in 2019/2020 will challenge global health for the future. Because a vaccine against the virus will not be available in the near future, we herein try to offer a pharmacological strategy to combat the virus. There exists a number of candidate drugs that may inhibi... |
First Middle East respiratory syndrome coronavirus (MERS-CoV) case in Southeast Asia (outside Middle East) | |
Chapter 11 New Technologies for Monitoring Marine Mammal Health | Abstract Omics technologies have been developed in recent decades and applied to different subjects, although the greatest advancements have been achieved in human biology and disease. Genome sequencing and the exploration of its coding and noncoding regions are rapidly yielding meaningful answers to diverse questions,... |
Quality Improvement Through the Introduction of Interdisciplinary Geriatric Hemodialysis Rehabilitation Care | Background Provision of rehabilitation with the aim of restoring personal independence in elderly hemodialysis patients faces several challenges. Design Quality improvement report. Setting & Participants First 3 years of experience of an inpatient geriatric hemodialysis rehabilitation program in Toronto. Patients with ... |
Where do we go from here? A child rights-based response to COVID-19 | |
Letter to the editor regarding “lack of supporting data make the risks of a clinical trial of radiation therapy as a treatment for COVID-19 pneumonia unacceptable” | |
Ethical and Legal Challenges During the COVID‐19 Pandemic – Are We Thinking About Rural Hospitals? | |
Emerging Antiviral Strategies to Interfere with Influenza Virus Entry | Influenza A and B viruses are highly contagious respiratory pathogens with a considerable medical and socioeconomical burden and known pandemic potential. Current influenza vaccines require annual updating and provide only partial protection in some risk groups. Due to the global spread of viruses with resistance to th... |
China's limited push model of FOI legislation | Abstract China has adopted a push model of Freedom of Information (FOI) legislation that emphasizes proactive disclosure of government information. This differs from a pull model that stresses citizen-initiated access or reactive disclosure. The push model of FOI legislation, which has reduced the importance of access ... |
Caught by NETs | |
Needlestick injuries: a density-equalizing mapping and socioeconomic analysis of the global research | BACKGROUND: Needlestick injuries have caused a deleterious effect on the physical and mental health of millions of health-care workers over the past decades, being responsible for occupational infections with viruses such as HIV or hepatis C. Despite this heavy burden of disease, no concise studies have been published ... |
Clinical practice guideline: Approach to childhood asthma in the era of COVID-19: The official statement endorsed by the Saudi Pediatric Pulmonology Association (SPPA) | Abstract Coronaviruses are a large family of viruses that can infect humans, which may result in mild symptoms similar to those of the common cold. COVID-19 is most recent subtype similar or even worse than the two previous pandemic strains which were the severe acute respiratory syndrome coronavirus (SARS-CoV) and the... |
The usefulness of case reports in managing emerging infectious disease | Emerging infectious diseases are an important problem in medicine. Case reports usually document episodes in the early emerging phase or in a small outbreak. Although the case report is considered weak evidence in medical literature, it is usually the first report when there is a new emerging infectious disease. There ... |
Molecular Typing and Epidemiology Profiles of Human Adenovirus Infection among Paediatric Patients with Severe Acute Respiratory Infection in China | BACKGROUND: Human adenoviruses (HAdVs) have been recognised as pathogens that cause a broad spectrum of diseases. The studies on HAdV infection among children with severe acute respiratory infection (SARI) are limited. OBJECTIVE: To investigate the prevalence, epidemiology, and genotype of HAdV among children with SARI... |
Infections virales et asthme | Summary Rhinovirus, parainfluenza, influenza, adenovirus and respiratory syncytial virus respiratory tract infections are frequent causes of asthmatic exacerbations, especially in children. All these viru3es can induce bronchial inflammation which, by adding to the allergic inflammation specific to asthma, can worsen t... |
Immortalization of Human B Cells: Analysis of B Cell Repertoire and Production of Human Monoclonal Antibodies | One of the major challenges in human B cell immunology field has been the objective to establish stable monoclonal cells lines that express the B cell receptor (BCR) on their cell surface and secrete antibodies. Such a system is extremely attractive not only for studying various aspect of BCR signaling but also for the... |
Detection of KI polyomavirus and WU polyomavirus DNA by real‐time polymerase chain reaction in nasopharyngeal swabs and in normal lung and lung adenocarcinoma tissues | Polyomaviruses KI (KIPyV) and WU (WUPyV) were detected from 7 (3.0%) and 38 (16.4%) of 232 children with respiratory tract infections by real‐time PCR. The rates of infection by KIPyV and WUPyV alone were 3 of 7 (42.9%) and 20 of 38 (52.6%), respectively. In the other samples, various viruses (human respiratory syncyti... |
Covid-19: Airborne transmission is being underestimated, warn experts. | |
Etiological analysis and predictive diagnostic model building of community-acquired pneumonia in adult outpatients in Beijing, China | BACKGROUND: Etiological epidemiology and diagnosis are important issues in adult community-acquired pneumonia (CAP), and identifying pathogens based on patient clinical features is especially a challenge. CAP-associated main pathogens in adults include viruses as well as bacteria. However, large-scale epidemiological i... |
Schistosomiasis control: experiences and lessons from China | |
Disruption of the CCL5/RANTES-CCR5 Pathway Restores Immune Homeostasis and Reduces Plasma Viral Load in Critical COVID-19 | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), is now pandemic with nearly three million cases reported to date. Although the majority of COVID-19 patients experience only mild or moderate symptoms, a subset will progress to severe disease with ... |
Monitoring of risk perceptions and correlates of precautionary behaviour related to human avian influenza during 2006 - 2007 in the Netherlands: results of seven consecutive surveys | BACKGROUND: Avian influenza (AI) is a public health challenge because of ongoing spread and pandemic potential. Non-pharmaceutical measures are important to prevent the spread of AI and to contain a pandemic. The effectiveness of such measures is largely dependent on the behaviour of the population. Risk perception is ... |
Modeling the formation of social conventions from embodied real-time interactions | What is the role of real-time control and learning in the formation of social conventions? To answer this question, we propose a computational model that matches human behavioral data in a social decision-making game that was analyzed both in discrete-time and continuous-time setups. Furthermore, unlike previous approa... |
Screening of Natural Extracts for Inhibitors against Japanese Encephalitis Virus Infection | The mosquito-borne Japanese encephalitis virus (JEV) causes serious illness worldwide that is associated with high morbidity and mortality. Currently, there are no effective drugs approved for the treatment of JEV infection. Drug-repurposing screening is an alternative approach to discover potential antiviral agents. I... |
Modulation of the Immune Response to Respiratory Viruses by Vitamin D | Background: Vitamin D deficiency has been shown to be independently associated with increased risk of viral acute respiratory infection (ARI) in a number of observational studies, and meta-analysis of clinical trials of vitamin D supplementation for prevention of ARI has demonstrated protective effects. Several cellula... |
Immobilization Techniques for Aptamers on Gold Electrodes for the Electrochemical Detection of Proteins: A Review | The development of reliable biosensing platforms plays a key role in the detection of proteins in clinically and environmentally derived samples for diagnostics, as well as for process monitoring in biotechnological productions. For this purpose, the biosensor has to be stable and reproducible, and highly sensitive to ... |
Porcine epidemic diarrhea virus virus-like particles produced in insect cells induce specific immune responses in mice | Porcine epidemic diarrhea virus (PEDV), which causes 80–100% mortality in neonatal piglets, is one of the most devastating viral diseases affecting swine worldwide. To date, the lack of effective vaccines and drugs is the main problem preventing control of the global spread of PEDV. In this study, we produced PEDV viru... |
COVID-19 IN 7 MULTIPLE SCLEROSIS PATIENTS IN TREATMENT WITH ANTI-CD20 THERAPIES | BACKGROUND AND AIM: In December 2019, the first cases of SARS-CoV-2 infection were detected in Wuhan. Within two months, it had begun to spread around the world in what became an unprecedented pandemic. Patients with Multiple Sclerosis (MS) in a state of immunosuppression may be considered at risk for complications in ... |
Confirmed Invasive Pulmonary Aspergillosis and COVID-19: the value of postmortem findings to support antemortem management | We present postmortem evidence of invasive pulmonary aspergillosis (IPA) in a patient with severe COVID-19. Autopsies of COVID-19 confirmed cases were performed. The patient died despite antimicrobials, mechanical ventilation, and vasopressor support. Histopathology and peripheral blood galactomannan antigen testing co... |
The unfolded protein response in virus infections | |
Synthesis of symmetrical and unsymmetrical 3,3-di(indolyl)indolin-2-ones under controlled catalysis of ionic liquids | Abstract Three ionic liquids, [BMIM][BF4] doped with 60mol% of LiCl ([BMIM][BF4]–LiCl), N,N,N,N-tetramethylguanidinium trifluoroacetate (TMGT), and N,N,N,N-tetramethylguanidinium triflate (TMGTf) were found useful as catalyst solvents for controlled 3-indolylation of isatins. Our investigation revealed that the reactio... |
What we know so far about Coronavirus Disease 2019 in children: A meta‐analysis of 551 laboratory‐confirmed cases | AIM: To summarize what we know so far about coronavirus disease (COVID‐19) in children. METHOD: We searched PubMed, Scientific Electronic Library Online, and Latin American and Caribbean Center on Health Sciences Information from 1 January 2020 to 4 May 2020. We selected randomized trials, observational studies, case s... |
Mechanism of Dayuanyin in the treatment of coronavirus disease 2019 based on network pharmacology and molecular docking | BACKGROUND: At present, coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2, is spreading all over the world, with disastrous consequences for people of all countries. The traditional Chinese medicine prescription Dayuanyin (DYY), a classic prescription for the ... |
Epstein-Barr Virus Nuclear Antigen 1 Recruits Cyclophilin A to Facilitate the Replication of Viral DNA Genome | Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1)-mediated DNA episomal genome replication and persistence are essential for the viral pathogenesis. Cyclophilin A (CYPA) is upregulated in EBV-associated nasopharyngeal carcinoma (NPC) with unknown roles. In the present approach, cytosolic CYPA was found to be bound wit... |
Mesenchymal Stem Cell Therapy for COVID-19: Present or Future | “COVID-19” is the word that certainly isn’t forgotten by everybody who lives in the first half of the twenty-first century. COVID-19, as a pandemic, has led many researchers from different biomedical fields to find solutions or treatments to manage the pandemic. However, no standard treatment for this disease has been ... |
Detection and Isolation of Exotic Newcastle Disease Virus from Field-Collected Flies | Flies were collected by sweep net from the vicinity of two small groups of "backyard" poultry (10–20 chickens per group) that had been identified as infected with exotic Newcastle disease virus (family Paramyxoviridae, genus avulavirus, ENDV) in Los Angeles County, CA, during the 2002–2003 END outbreak. Collected flies... |
The C Type Lectins DC-SIGN and L-SIGN: Receptors for Viral Glycoproteins | DC-SIGN and L-SIGN are C-type lectins that recognize carbohydrate structures present on viral glycoproteins and function as attachment factors for several enveloped viruses. DC-SIGN and L-SIGN enhance viral entry and facilitate infection of cells that express the cognate entry receptor (cis-infection). They are also ab... |
Equine influenza and air transport | |
The Novel Coronavirus Outbreak: What We Know and What We Don’t | |
Emerging Manufacturers engagements in the COVID -19 vaccine research, development and supply | The World Health Organization declared the COVID-19 disease as a pandemic requiring a rapid response. Through online search, direct communication with network members and an internal survey, engagements of developing countries’ vaccine manufacturers’ network members in the research and development of COVID-19 vaccines ... |
Rethinking Smallpox | The potential consequences of a competently executed smallpox attack have not been adequately considered by policy makers. The possibility of release of an aerosolized and/or bioengineered virus must be anticipated and planned for. The transmission and infectivity of variola virus are examined. Arguments for and agains... |
Professional Educational Opportunities | |
Perioperative Considerations in Urgent Surgical Care of Suspected and Confirmed Coronavirus Disease 2019 Orthopaedic Patients: Operating Room Protocols and Recommendations in the Current Coronavirus Disease 2019 Pandemic | By April 7, 2020, severe acute respiratory syndrome coronavirus 2 was responsible for 1,383,436 confirmed cases of Coronavirus disease 2019 (COVID-19), involving 209 countries around the world; 378,881 cases have been confirmed in the United States. During this pandemic, the urgent surgical requirements will not stop. ... |
Automating the Classification of Complexity of Medical Decision-Making in Patient-Provider Messaging in a Patient Portal | BACKGROUND: Patient portals are consumer health applications that allow patients to view their health information. Portals facilitate the interactions between patients and their caregivers by offering secure messaging. Patients communicate different needs through portal messages. Medical needs contain requests for deli... |
Integration of the Gene Ontology into an object-oriented architecture | BACKGROUND: To standardize gene product descriptions, a formal vocabulary defined as the Gene Ontology (GO) has been developed. GO terms have been categorized into biological processes, molecular functions, and cellular components. However, there is no single representation that integrates all the terms into one cohesi... |
Identifying strategies to improve access to credible and relevant information for public health professionals: a qualitative study | BACKGROUND: Movement towards evidence-based practices in many fields suggests that public health (PH) challenges may be better addressed if credible information about health risks and effective PH practices is readily available. However, research has shown that many PH information needs are unmet. In addition to review... |
Acuted Disseminated Encephalomyelitis | Acute disseminated encephalomyelitis (ADEM) is a disorder of the central nervous system (CNS) characterized by an acute event, typically with encephalopathy, in which diffuse CNS involvement occurs. It may follow an infectious event and occurs more commonly in young children. Pulse steroid treatment is frequently used ... |
Small-Molecule Antiviral β-d-N(4)-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance | Coronaviruses (CoVs) have emerged from animal reservoirs to cause severe and lethal disease in humans, but there are currently no FDA-approved antivirals to treat the infections. One class of antiviral compounds, nucleoside analogues, mimics naturally occurring nucleosides to inhibit viral replication. While these comp... |
Initial Steps in Mammalian Autophagosome Biogenesis | During the last decade, autophagy has been pointed out as a central process in cellular homeostasis with the consequent implication in most cellular settings and human diseases pathology. At present, there is significant data available about molecular mechanisms that regulate autophagy. Nevertheless, autophagy pathway ... |
COVID-19 y la esperanza de la inmunidad | |
Cutaneous Dengue Virus Inoculation Triggers Strong B Cell Reactions but Contrastingly Poor T Cell Responses | Dengue is a global health problem without current specific treatment nor safe vaccines available. While severe dengue is related to pre-existing non-neutralizing dengue virus (DENV) antibodies, the role of T cells in protection or pathology is unclear. Using cutaneous DENV infection in immunocompetent mice we previousl... |
At the center of the COVID‐19 pandemic: Lessons learned for otolaryngology‐head and neck surgery in China | |
COVID ‐19 and the gastroenterologist | |
A contextual behavioral approach for responding to moral dilemmas in the age of COVID-19()() | Prior pandemics and current news stories suggest that a “second pandemic” of potentially devastating mental health consequences will follow the COVID-19 pandemic. Given the changing contextual demands associated with the pandemic for many people, the mental health consequences of COVID-19 are likely to include exposure... |
Coronaviruses and the human airway: a universal system for virus-host interaction studies | Human coronaviruses (HCoVs) are large RNA viruses that infect the human respiratory tract. The emergence of both Severe Acute Respiratory Syndrome and Middle East Respiratory syndrome CoVs as well as the yearly circulation of four common CoVs highlights the importance of elucidating the different mechanisms employed by... |
Acute otitis media and respiratory viruses | The present study was performed to elucidate the clinical outcome, and etiology of acute otitis media (AOM) in children based on virologic and bacteriologic tests. The study group consisted of 120 children aged 6 to 144 months with AOM. Middle ear fluid (MEF) was tested for viral pathogens by reverse transcriptase poly... |
Is Vitamin D One of the Key Elements in COVID-19 Days? | |
Genomic and protein structure modelling analysis depicts the origin and infectivity of 2019-nCoV, a new coronavirus which caused a pneumonia outbreak in Wuhan, China | Detailed genomic and structure-based analysis of a new coronavirus, namely 2019-nCoV, showed that the new virus is a new type of bat coronavirus and is genetically fairly distant from the human SARS coronavirus. Structure analysis of the spike (S) protein of this new virus showed that its S protein only binds weakly to... |
A Porcine Epidemic Diarrhea Virus Outbreak in One Geographic Region of the United States: Descriptive Epidemiology and Investigation of the Possibility of Airborne Virus Spread | This study describes a spring 2013 outbreak of porcine epidemic diarrhea virus (PEDv), using data from 222 swine sites in 14 counties area in 4 contiguous states in the United States. During the outbreak, the premises-level incidence of PEDv was 40.5 percent (90/222 sites). One of the three companies from which data we... |
Obesity is Associated with Severe Forms of COVID‐19 | We have read with great interest the Brief Cutting Edge Report from Simonnet et al. which reports a high prevalence of obesity in severe acute respiratory syndrome coronavirus-2 (SARS-Cov-2) requiring invasive mechanical ventilation. In the context of unprecedented health crisis due to the coronavirus disease 2019 (COV... |
Feeding associated neonatal necrotizing enterocolitis (Primary NEC) is an inflammatory bowel disease | Abstract Neonatal necrotizing enterocolitis which develops after feeding preterm infants is characterized by severe intestinal inflammation and profound systemic metabolic acidosis. The fermentation of undigested dietary carbohydrate by colonic flora yields gases (CO2 and H2) and short chain organic acids. These organi... |
A primer on COVID‐19 Mathematical Models | The emergence of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2 or COVID‐19) disease has led to a wide‐spread global pandemic (1). COVID‐19 symptoms and mortality are disproportionately more severe in people with obesity and obesity related comorbidities (2, 3). This is of concern for the United States, wh... |
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