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On the crucial role of multilingual biomedical databases on epidemic events (SARS-CoV-2 analysis) | |
Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals | IFIT (interferon-induced with tetratricopeptide repeats) proteins are critical mediators of mammalian innate antiviral immunity. Mouse IFIT1 selectively inhibits viruses that lack 2'O-methylation of their mRNA 5' caps. Surprisingly, human IFIT1 does not share this antiviral specificity. Here, we resolve this discrepanc... |
Veterans’ Response to an Automated Text Messaging Protocol During the COVID-19 Pandemic | The US Department of Veterans Affairs (VA) is using an automated short message service (SMS) application named ‘Annie’ as part of their COVID-19 response with a protocol for coronavirus precautions, which can help the Veteran monitor symptoms and can advise the Veteran when to contact their VA care team or a nurse tria... |
Nipah virus: Impact, origins, and causes of emergence | Nipah virus is an emerging zoonotic pathogen that causes severe febrile encephalitis resulting in death in 40% to 75% of human cases. Nipah virus is considered a biosafety level-4 pathogen and is listed as a select agent with high risk for public health and security due to its high mortality rate in people and the lack... |
Human SCARB2-Mediated Entry and Endocytosis of EV71 | Enterovirus (EV) 71 infection is known to cause hand-foot-and-mouth disease (HFMD) and in severe cases, induces neurological disorders culminating in fatality. An outbreak of EV71 in South East Asia in 1997 affected over 120,000 people and caused neurological disorders in a few individuals. The control of EV71 infectio... |
On the usefulness of point-of-care antibody tests for SARS-CoV-2 in community screening settings | |
Unrealistic Optimism in the Time of Coronavirus Pandemic: May It Help to Kill, If So—Whom: Disease or the Person? | Objective: The results of numerous empirical studies have showed the occurrence of so-called unrealistic optimism. Thus, we aimed to investigate whether in the situation of an imminent coronavirus pandemic, people would still perceive themselves as being less exposed to the disease than others. Methods: Survey studies ... |
Human herpesvirus 6 and multiple sclerosis: A study of t cell cross‐reactivity to viral and myelin basic protein antigens | Several reports have suggested an association of human herpesvirus 6 (HHV‐6) with multiple sclerosis. Autoreactive T lymphocytes directed against myelin components seem to contribute to the pathogenesis of the disease. It has been suggested that molecular mimicry between viral and self‐antigens might be one of the mech... |
Individual variation of the SARS‐CoV‐2 receptor ACE2 gene expression and regulation | The COVID‐19 coronavirus is now spreading worldwide. Its pathogen, SARS‐CoV‐2, has been shown to use angiotensin‐converting enzyme 2 (ACE2) as its host cell receptor, same as the severe acute respiratory syndrome coronavirus (SARS‐CoV) in 2003. Epidemiology studies found males although only slightly more likely to be i... |
Reply to Comments on 'Co‐infection of SARS‐CoV‐2 and HIV in a patient in Wuhan city, China’ | Coronovirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronovirus 2 (SARS‐CoV‐2) infection has been ranging in China throughout the world now. The World Health Organiztion declared the COVID‐19 crisis a global pandemic. The previous our case of co‐infection of SARS‐CoV‐2 and HIV has raised the... |
Alliances for scientific success | The diverse histories of China's cities strongly influence their collaboration patterns. |
Progressive CT findings and positive RT-PCR again of recovered and discharged patients with COVID-19 | |
Filtration and inactivation of aerosolized bacteriophage MS2 by a CNT air filter fabricated using electro-aerodynamic deposition | Abstract Carbon nanotubes (CNTs) were coated on a sample of glass fiber air filter medium at atmospheric pressure and room temperature using electro-aerodynamic deposition (EAD). In the EAD method, CNTs (diameter: 50nm, length: 2–3μm) were aerosolized, electrically charged, and injected through a nozzle. A voltage was ... |
Incidence of Acute Ischemic Stroke and Rate of Mechanical Thrombectomy During the COVID-19 Pandemic in a Large Tertiary Care Telemedicine Network | |
Infections and exercise in high‐performance athletes | The elite athlete has a potentially increased sensitivity to respiratory infections, rendering protective measures particularly important. Some other infections that may appear in clusters in the sports setting, such as gastroenteritis, leptospirosis, herpes simplex and viral hepatitis, also require special precautiona... |
Spatio-temporal evolution of Beijing 2003 SARS epidemic | Studying spatio-temporal evolution of epidemics can uncover important aspects of interaction among people, infectious diseases, and the environment, providing useful insights and modeling support to facilitate public health response and possibly prevention measures. This paper presents an empirical spatio-temporal anal... |
Candidate Genes Associated with Susceptibility for SARS-Coronavirus | Assuming that no human had any previously acquired immunoprotection against severe acute respiratory syndrome coronavirus (SARS-CoV) during the 2003 SARS outbreak, the biological bases for possible difference in individual susceptibility are intriguing. However, this issue has never been fully elucidated. Based on the ... |
Conversations and Medical News Frames on Twitter: Infodemiological Study on COVID-19 in South Korea | BACKGROUND: SARS-CoV-2 (severe acute respiratory coronavirus 2) was spreading rapidly in South Korea at the end of February 2020 following its initial outbreak in China, making Korea the new center of global attention. The role of social media amid the current coronavirus disease (COVID-19) pandemic has often been crit... |
Self-assembled Star-shaped Chiroplasmonic Gold Nanoparticles for Ultrasensitive Chiro-immunosensor of Viruses | Near field optics and optical tunneling light-matter interaction in the superstructure of chiral nanostructures and semiconductor quantum dots exhibit strong optical rotation activity that may open a new window for chiral-based bioanalytes detection. Herein we report an ultrasensitive, chiro-immunosensor using superstr... |
Financial time series analysis based on information categorization method | Abstract The paper mainly applies the information categorization method to analyze the financial time series. The method is used to examine the similarity of different sequences by calculating the distances between them. We apply this method to quantify the similarity of different stock markets. And we report the resul... |
The global challenges of infectious diseases | |
Effects of nationwide lockdown during COVID-19 epidemic on lifestyle and other medical issues of patients with type 2 diabetes in north India | BACKGROUND AND AIMS: During the current pandemic of COVID-19 India is under lockdown which could cause disruption in diet and lifestyle in patients with type 2 diabetes (T2DM). We aimed to study lifestyle changes and other common issues related to treatment in our previously seen and treated patients with T2DM. METHODS... |
Serum 25-Hydroxyvitamin D and the Incidence of Acute Viral Respiratory Tract Infections in Healthy Adults | BACKGROUND: Declining serum concentrations of 25-hydroxyvitamin D seen in the fall and winter as distance increases from the equator may be a factor in the seasonal increased prevalence of influenza and other viral infections. This study was done to determine if serum 25-hydroxyvitamin D concentrations correlated with ... |
Factores asociados a la incidencia y la mortalidad por COVID-19 en las comunidades autónomas | RESUMEN Objetivo: Analizar la evolución de la epidemia de COVID-19 después del estado de alarma e identificar factores asociados a las diferencias entre las comunidades autónomas. Método: Estudio ecológico que utilizó variables epidemiológicas, demográficas, ambientales y sobre la estructura de los servicios sanitarios... |
Multiple sequence alignment of the M protein in SARS-associated and other known coronaviruses | In this paper, we report a multiple sequence alignment result on the basis of 10 amino acid sequences of the M protein, which come from different coronaviruses (4 SARS-associated and 6 others known). The alignment model was based on the profile HMM (Hidden Markov Model), and the model training was implemented through t... |
Immune response of mature cows subjected to annual booster vaccination against neonatal calf diarrhoea with two different commercial vaccines: A non-inferiority study | Abstract Neonatal calf diarrhoea can have important economic consequences. Scour vaccines are available against some of the most frequent pathogens responsible for this disease: Bovine Rotavirus (BoRV), Bovine Coronavirus (BoCV) and E. coli K99. In this multi-centre, randomised, blinded study, adult cows vaccinated wit... |
Seroprevalence of economically important viral pathogens in swine populations of Trinidad and Tobago, West Indies | The objective of this study was to evaluate the seroprevalence and identify the strains of swine influenza virus (SwIV), as well as the seroprevalence of porcine parvovirus (PPV), transmissible gastroenteritis virus (TGEV), porcine reproductive and respiratory syndrome virus (PRRSV), porcine respiratory coronavirus (PR... |
Health services restructuring in Alberta and the 2009 pandemic influenza—An untimely concurrence | In the last 12 years, every Canadian province and territory has undertaken significant health services restructuring, with the pace of change accelerating recently. When the H1N1 Pandemic Influenza (PI) hit Alberta in the spring of 2009, the province had just begun a restructuring of health services of a scale unpreced... |
COVID‐19 related home confinement in adults: weight gain risks and opportunities | As the global COVID‐19 pandemic unfolds, over 90% of U.S. adult residents are confined to their homes, with restaurants, shops, schools, and workplaces shut down to prevent disease spread. While it is a priority to mitigate the immediate impact, one area of great concern is the long‐term effects of this pandemic on wei... |
Bioaerosol sampling for the detection of aerosolized influenza virus | Background Influenza virus was used to characterize the efficacy of a cyclone‐based, two‐stage personal bioaerosol sampler for the collection and size fractionation of aerosolized viral particles. Methods A Collison single‐jet nebulizer was used to aerosolize the attenuated FluMist® vaccine into a calm‐air settling cha... |
Peritoneal dialysis: the ideal bridge from conservative therapy to kidney transplant | BACKGROUND: Kidney transplantation offers the best potential for full rehabilitation in patients with end-stage kidney disease who are treated with dialysis. However, due to organ shortage which is a universal phenomenon, most patients need to be maintained on a period of dialysis therapy before the prospect of transpl... |
Chapter 16 Other Negative-Strand RNA Viruses | Abstract In this chapter, four miscellaneous negative-strand RNA viruses are covered briefly with emphasis on the genome structure: paramyxoviruses, filoviruses, bunyaviruses, and arenaviruses. Paramyxoviruses and filoviruses belong to the order Mononegavirales, having one negative-strand RNA genome, while bunyaviruses... |
COVID-19—does social distancing include species distancing? | |
Chaos game representation dataset of SARS-CoV-2 genome | Abstract As of April 16, 2020, the novel coronavirus disease (called COVID-19) spread to more than 185 countries/regions with more than 142,000 deaths and more than 2,000,000 confirmed cases. In the bioinformatics area, one of the crucial points is the analysis of the virus nucleotide sequences using approaches such as... |
Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR | BACKGROUND: The ongoing outbreak of the recently emerged novel coronavirus (2019-nCoV) poses a challenge for public health laboratories as virus isolates are unavailable while there is growing evidence that the outbreak is more widespread than initially thought, and international spread through travellers does already ... |
Microbiology Select | The interactions between virus proteins and host cells are intricate and impact diverse processes. Recent papers explored in this issue's Microbiology Select reveal unexpected mechanisms by which viruses interact with host cells to facilitate infection, promote replication of their genomes, and foster horizontal gene t... |
COVID-19 Journal de bord- 13 avril 2020: Violences conjugales et confinement | |
Misinformation and de-contextualization: international media reporting on Sweden and COVID-19 | In the first month of the 2020 COVID-19 pandemic, Sweden took the same strategy as most other countries, working to “flatten the curve,” by slowing transmission so that the healthcare system could cope with the disease. However, unlike most other countries, much of Sweden’s implementation focused on voluntary and stepw... |
An evaluation of psychological distress and social support of survivors and contacts of Ebola virus disease infection and their relatives in Lagos, Nigeria: a cross sectional study − 2014 | BACKGROUND: By September 2014, an outbreak of Ebola Viral Disease (EVD) in West African countries of Guinea, Liberia, Sierra Leone, Senegal and Nigeria, had recorded over 4500 and 2200 probable or confirmed cases and deaths respectively. EVD, an emerging infectious disease, can create fear and panic among patients, con... |
Protocolo de manejo hospitalario de alteraciones electrocardiográficas en pacientes con COVID-19 con un sistema portátil vinculado a smartphone | |
Optimization of potassium for proper growth and physiological response of Houttuynia cordata Thunb. | Abstract Houttuynia cordata Thunb. is an edible herb with a variety of pharmacological activities, but only limited information is available about its response towards potassium supplementation. Sterile plantlets were cultured in media with different potassium levels, and parameters related to growth, foliar potassium,... |
Virtual drug repurposing study against SARS-CoV-2 TMPRSS2 target | Currently, the world suffers from a new coronavirus SARS-CoV-2 that causes COVID-19. Therefore, there is a need for the urgent development of novel drugs and vaccines for COVID-19. Since it can take years to develop new drugs against this disease, here we used a hybrid combined molecular modeling approach in virtual dr... |
Wildlife, Exotic Pets, and Emerging Zoonoses | Most emerging infectious diseases are zoonotic; wildlife constitutes a large and often unknown reservoir. Wildlife can also be a source for reemergence of previously controlled zoonoses. Although the discovery of such zoonoses is often related to better diagnostic tools, the leading causes of their emergence are human ... |
No evidence for the effectiveness of systemic corticosteroids in acute pharyngitis, community-acquired pneumonia and acute otitis media | Corticosteroids have been used to treat infectious diseases for more than 50 years but, although it has been shown that they are highly effective in improving the clinical course of some diseases, their effects have not been clearly defined in others. Nevertheless, they are still used by a considerable number of physic... |
Adaptation to SARS‐CoV‐2 under stress: Role of distorted information | BACKGROUND: Since the time of global SARS‐CoV‐2 spread across the earth in February 2020, most of countries faced the problem of massive stress of their healthcare systems. In many cases, the structural stress was a result of incorrect allocation of medical care resources. In turn, this misallocation resulted from fear... |
Diagnostic performance of 7 rapid IgG/IgM antibody tests and the Euroimmun IgA/IgG ELISA in COVID-19 patients | OBJECTIVES: To evaluate the diagnostic performance of 7 rapid IgG/IgM tests and the Euroimmun IgA/IgG ELISA for antibodies against SARS-CoV-2 in COVID-19 patients. METHODS: Specificity was evaluated in 103 samples collected before January 2020. Sensitivity and time to seropositivity was evaluated in samples from 94 pat... |
Validation of Reference Genes for Gene Expression Studies in Aphis glycines (Hemiptera: Aphididae) | Quantitative real-time polymerase chain reaction (qRT-PCR) is a common and robust tool for accurate quantification of mRNA transcripts. To normalize results, a housekeeping gene ([HKG], reference gene or endogenous control gene) is mandatory. Soybean aphid, Aphis glycines Matsumura (Hemiptera: Aphididae), is a signific... |
Respiratory Viruses in Lung Transplant Recipients: A Critical Review and Pooled Analysis of Clinical Studies | Lung transplant recipients present an increased risk for severe complications associated with respiratory infections. We conducted a review of the literature examining the clinical relationship between viral respiratory infection and graft complications. Thirty‐four studies describing the clinical impact of influenza, ... |
Human rhinovirus C—Associated severe pneumonia in a neonate | Abstract We present a case of severe pneumonia, associated with a prolonged infection by a species C rhinovirus (HRV) in a 3-week old neonate. HRV RNA was identified in nasal and nasopharyngeal secretions, bronchoalveolar lavage and bronchial specimens, stool and urine, collected from the patient during a one-month per... |
Pro/con clinical debate: Steroids are a key component in the treatment of SARS | SARS (severe acute respiratory syndrome) proved an enormous physical and emotional challenge to frontline health care workers throughout the world in late 2002 through to mid 2003. A large percentage of patients (many being health care workers themselves) became critically ill. Unfortunately, clinicians caring for thes... |
Full-Genome Sequence Analysis of a Variant Strain of Porcine Epidemic Diarrhea Virus in South Korea | In March of 2014, a variant of novel porcine epidemic diarrhea virus (PEDV) was first identified in South Korea and found to be most closely related to the U.S. variant strain OH851. The complete genome of the KOR/KNU-1406/2014 strain was sequenced and analyzed to investigate the U.S.-strain-like variant circulating in... |
Using the Kulldorff’s scan statistical analysis to detect spatio-temporal clusters of tuberculosis in Qinghai Province, China, 2009–2016 | BACKGROUND: Although the incidence of tuberculosis (TB) in most parts of China are well under control now, in less developed areas such as Qinghai, TB still remains a major public health problem. This study aims to reveal the spatio-temporal patterns of TB in the Qinghai province, which could be helpful in the planning... |
Candidiasis and other oral mucosal lesions during and after interferon therapy for HCV-related chronic liver diseases | BACKGROUND: Oral lichen planus (OLP) is seen frequently in patients with hepatitis C virus (HCV) infection. The aim of this study was to evaluate the occurrence of oral candidiasis, other mucosal lesions, and xerostomia during interferon (IFN) therapy for HCV infection. METHODS: Of 124 patients with HCV-infected liver ... |
The Spread of Influenza and Other Respiratory Viruses: Complexities and Conjectures | |
From H1N1 to 2019-nCoV, what do we learn? | |
Infections at the Animal/Human Interface: Shifting the Paradigm from Emergency Response to Prevention at Source | The majority of emerging infectious diseases have their source in animals, and emergence occurs at the human/animal interface, when infections in animals breech the species barrier to infect humans, the population in which they are often first identified. The response is frequently characterized by a series of emergenc... |
Problems in physiological experimental animal models investigated with factorial design | Abstract In the present study we investigated four variables using factorial design to decide if any of these could explain the variations in the control measurements of interstitial fluid pressure (P if) in rat trachea that were experienced. This approach requires only a fraction of the animals normally needed when st... |
2020 ACR Presidential Address: Quality, Ownership, and Our Role as Physicians | Abstract A story from long ago reminds us of the importance of quality in our practices, of taking ownership of our patients, and of our role as physicians. The coronavirus disease 2019 (COVID-19) pandemic has disrupted our practices. Before the pandemic, many practices were stretched thin by the amount of work that ne... |
Relevance of SARS-CoV-2 in food safety and food hygiene: potential preventive measures, suggestions and nanotechnological approaches | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is easily transmitted from person to person, which has fueled the ongoing pandemic. Governments in different countries have taken drastic actions such as complete lockdown. However, little attention has been paid to food safety and its potential linkage with ... |
Chikungunya: A Potentially Emerging Epidemic? | Chikungunya virus is a mosquito-borne emerging pathogen that has a major health impact in humans and causes fever disease, headache, rash, nausea, vomiting, myalgia, and arthralgia. Indigenous to tropical Africa, recent large outbreaks have been reported in parts of South East Asia and several of its neighboring island... |
siRNA silencing of angiotensin-converting enzyme 2 reduced severe acute respiratory syndrome-associated coronavirus replications in Vero E6 cells | The outbreak of severe acute respiratory syndrome (SARS) in 2002–2003 has had a significant impact worldwide. No effective prophylaxis or treatment for SARS is available up to now. Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for SARS-associated coronavirus (SARS-CoV). By expressing a U6 promoter-dri... |
Bat Airway Epithelial Cells: A Novel Tool for the Study of Zoonotic Viruses | Bats have been increasingly recognized as reservoir of important zoonotic viruses. However, until now many attempts to isolate bat-borne viruses in cell culture have been unsuccessful. Further, experimental studies on reservoir host species have been limited by the difficulty of rearing these species. The epithelium of... |
Understanding SARS‐CoV‐2 endocytosis for COVID‐19 drug repurposing | The quest for the effective treatment against coronavirus disease 2019 pneumonia caused by the severe acute respiratory syndrome (SARS)‐coronavirus 2(CoV‐2) coronavirus is hampered by the lack of knowledge concerning the basic cell biology of the infection. Given that most viruses use endocytosis to enter the host cell... |
A cluster-randomised controlled trial to test the efficacy of facemasks in preventing respiratory viral infection among Hajj pilgrims | Abstract Background Cost-effective interventions are needed to control the transmission of viral respiratory tract infections (RTIs) in mass gatherings. Facemasks are a promising preventive measure, however, previous studies on the efficacy of facemasks have been inconclusive. This study proposes a large-scale facemask... |
Rapidly fatal pneumonitis from immunotherapy and concurrent SARS-CoV-2 infection in a patient with newly diagnosed lung cancer | Immune checkpoint inhibitors (ICIs) are used for the treatment of numerous cancers, but risks associated with ICI-therapy during the COVID-19 pandemic are poorly understood. We report a case of acute lung injury in a lung cancer patient initially treated for ICI-pneumonitis and later found to have concurrent SARS-CoV-2... |
Identify-Isolate-Inform: A Tool for Initial Detection and Management of Zika Virus Patients in the Emergency Department | First isolated in 1947 from a monkey in the Zika forest in Uganda, and from mosquitoes in the same forest the following year, Zika virus has gained international attention due to concerns for infection in pregnant women potentially causing fetal microcephaly. More than one million people have been infected since the ap... |
Transmission of SARS-CoV-2: an update of current literature | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent for the 2019 coronavirus disease (COVID-19) pandemic, has caused a public health emergency. The need for additional research in viral pathogenesis is essential as the number of cases and deaths rise. Understanding the virus and its abilit... |
Mast cells contribute to coronavirus-induced inflammation: new anti-inflammatory strategy. | Coronavirus, which can cause respiratory syndrome, to date has affected over seventeen thousand individuals, especially in China. Coronavirus is interspecies and can also be transmitted from man to man, with an incubation ranging from 1 to 14 days. Human coronavirus infections can induce not only mild to severe respira... |
Implementation of an OSCE at Kaohsiung Medical University | The Objective Structured Clinical Examination (OSCE), a tool to objectively and fairly assess medical students' clinical competences, has become widely used in medical education worldwide. However, most medical schools in Taiwan have just begun to adopt this assessment method. In 2003, Kaohsiung Medical University (KMU... |
Clinical trials during COVID‐19 | As this ever‐evolving pandemic lays itself, more of its impact is being understood. Until recently, most guidelines were reported to aid in managing and treating suspected or confirmed cases. Research institutions around the world are responding with a sense of confusion. Some are continuing routinely, especially those... |
Impact of Mated Female Nonproductive Days in Breeding Herd after Porcine Epidemic Diarrhea Virus Outbreak | Porcine epidemic diarrhea virus (PEDV) is an important pathogen that has a significant economic impact on the swine industry by imposing a high rate of mortality in suckling piglets. However, limited information on the productivity values of gilts and sows infected with PEDV is available. Here, we evaluate the producti... |
Am I a Coronavirus? | |
Biomaterials Made from Coiled-Coil Peptides | The development of biomaterials designed for specific applications is an important objective in personalized medicine. While the breadth and prominence of biomaterials have increased exponentially over the past decades, critical challenges remain to be addressed, particularly in the development of biomaterials that exh... |
Clinical characteristics of 194 cases of COVID-19 in Huanggang and Taian, China | PURPOSE: We aimed to report the clinical characteristics of 194 cases coronavirus disease-19 (COVID-19) in Huanggang, Hubei and Taian, Shandong. METHODS: We retrospectively investigated the clinical, laboratory characteristics and CT imaging of confirmed cases of COVID-19 from January 22 to February 28, 2020 in Huangga... |
China’s experience on mental health in response to the COVID-19 pandemic | |
Polycyclic N‐Benzamido Imides with Potent Activity against Vaccinia Virus | The synthesis and antiviral activity of a series of novel polycyclic analogues of the orthopoxvirus egress inhibitor tecovirimat (ST‐246) is presented. Several of these compounds display sub‐micromolar activity against vaccinia virus, and were more potent than cidofovir (CDV). The more active compounds were about 10‐fo... |
Acute Type A Aortic Dissection Complicated by COVID-19 Infection | Abstract A patient underwent surgery for acute type A aortic dissection. SARS- CoV-2 was positive. The postoperative course was complicated by a mixed viral/bacterial pneumonia with bilateral infiltration, treated with antibiotics and hydroxychloroquine, without any need for reintubation. The patient recovered and fina... |
Reply to ‘Ibuprofen and thromboembolism in SARS‐COV2’ | We appreciate the opportunity to respond to the comments by Drs. Arian Arjomandi Rad, Robert Vardanyan and Natalie R Tas. Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely used in many countries for the relief of symptoms of pain, inflammation and fever, which reduce the conversion of arachidonic acid to prosta... |
Electrocardiographic features of patients with COVID-19 pneumonia | BACKGROUND: . The electrocardiographic (ECG) changes which may occur during hospitalization for COVID-19 have not yet been comprehensively assessed. PATIENTS AND METHODS: . We examined 50 patients admitted to hospital with proven COVID-19 pneumonia. At entry, all patients underwent a detailed clinical examination, 12-l... |
Characteristics of laboratory indexes in COVID-19 patients with non-severe symptoms in Hefei City, China: diagnostic value in organ injuries | This study compared the laboratory indexes in 40 non-severe COVID-19 patients with those in 57 healthy controls. In the peripheral blood system of non-severe symptom COVID-19 patients, lymphocytes, eosinophils, basophils, total procollagen type 1 amino-terminal propeptide, osteocalcin N-terminal, thyroid-stimulating ho... |
Statistical analysis and visualization of the potential cases of pandemic coronavirus | A local outbreak of initially unknown cause pneumonia was detected in Wuhan (Hubei, China) in December 2019 and a novel coronavirus, the severe acute respiratory syndrome coronavirus 2, was quickly found to be causing it. Since then, the epidemic has spread to all of China's mainland provinces as well as 58 other count... |
The association of SARS-CoV-2 infection and acute disseminated encephalomyelitis without prominent clinical pulmonary symptoms | • We describe a patient with acute disseminated encephalitis and COVID-19. • CNS manifestations primarily occurred without evident pulmonary symptoms. • Brain MRI of the patient indicated diffuse confluent white matter hyperintensities. • The patient initially responded to steroids but lastly, died of status epilepticu... |
Neurologic manifestations of nonhospitalized patients with COVID‐19 in Wuhan, China | |
Infectious disease risk from the Syrian conflict | |
The Herpes Simplex Virus-1 genome contains multiple clusters of repeated G-quadruplex: Implications for the antiviral activity of a G-quadruplex ligand | Abstract Guanine-rich nucleic acids can fold into G-quadruplexes, secondary structures implicated in important regulatory functions at the genomic level in humans, prokaryotes and viruses. The remarkably high guanine content of the Herpes Simplex Virus-1 (HSV-1) genome prompted us to investigate both the presence of G-... |
Cxcl16 interact with SARS-CoV N protein in and out cell | Our study investigated the host cell protein which can interact with SARS-CoV N protein, and explored the functional connections. The eukaryotic expression vectors pEGFP-N1/SARS-CoVN and pdsRed2-N1/CXCL16 were constructed and used to co-transfect HEK293FT cells by the calcium phosphate method. The HIS-tagged fusion pro... |
Clinical characteristics and risk factors associated with COVID-19 disease severity in patients with cancer in Wuhan, China: a multicentre, retrospective, cohort study | BACKGROUND: COVID-19 has spread globally. Epidemiological susceptibility to COVID-19 has been reported in patients with cancer. We aimed to systematically characterise clinical features and determine risk factors of COVID-19 disease severity for patients with cancer and COVID-19. METHODS: In this multicentre, retrospec... |
Digital technology in psychiatry: towards the implementation of a true person-centered care in psychiatry? | |
Global assessment of environment, health and economic impact of the novel coronavirus (COVID-19) | The institution of social distancing and punitive measures to contain the spread of COVID-19 through human-to-human transmission has environmental, health and economic impact. While the global pandemic has led to the enhancement of the health system and decline of emissions, economic development appears deteriorating. ... |
SUBCELLULAR LOCALIZATION OF SARS-CoV STRUCTURAL PROTEINS | |
Isolation and Characterization of Dromedary Camel Coronavirus UAE-HKU23 from Dromedaries of the Middle East: Minimal Serological Cross-Reactivity between MERS Coronavirus and Dromedary Camel Coronavirus UAE-HKU23 | Recently, we reported the discovery of a dromedary camel coronavirus UAE-HKU23 (DcCoV UAE-HKU23) from dromedaries in the Middle East. In this study, DcCoV UAE-HKU23 was successfully isolated in two of the 14 dromedary fecal samples using HRT-18G cells, with cytopathic effects observed five days after inoculation. North... |
Association of Increased Bcl‐2 Expression with Rescue from Tumor Necrosis Factor‐α‐Induced Cell Death in the Oligodendrocyte Cell Line OLN‐93 | Abstract: The present study investigated the effects of flupirtine(Katadolon) on tumor necrosis factor (TNF)‐α‐mediated cell death andBcl‐2 expression in the permanent rat oligodendrocyte cell line OLN‐93 (OLNcells). TNF‐α (500 U/ml) induced apoptosis of OLN cells, which wasconfirmed by DNA fragmentation using an in si... |
Murine Norovirus 1 (MNV1) Replication Induces Translational Control of the Host by Regulating eIF4E Activity during Infection | Protein synthesis is a tightly controlled process responding to several stimuli, including viral infection. As obligate intracellular parasites, viruses depend on the translation machinery of the host and can manipulate it by affecting the availability and function of specific eukaryotic initiation factors (eIFs). Huma... |
A Protocol for the Multi-Omic Integration of Cervical Microbiota and Urine Metabolomics to Understand Human Papillomavirus (HPV)-Driven Dysbiosis | The multi-omic integration of microbiota data with metabolomics has gained popularity. This protocol is based on a human multi-omics study, integrating cervicovaginal microbiota, HPV status and neoplasia, with urinary metabolites. Indeed, to understand the biology of the infections and to develop adequate interventions... |
Reply to: ‘Younger patients with MAFLD are at increased risk of severe COVID-19 illness: A multicenter preliminary analysis’ | |
Smart campus—A sketch | Abstract Smart campus is an emerging trend that allows educational institutions to combine smart technologies with physical infrastructure for improved services, decision making, campus sustainability etc. Under the umbrella of smart campus, various solutions have been implemented on campus levels such as smart microgr... |
Vaccines and Vaccination for Veterinary Viral Diseases: A General Overview | A high number of infectious diseases affecting livestock and companion animals are caused by pathogens of viral etiology. Ensuring the maximum standards of quality and welfare in animal production requires developing effective tools to halt and prevent the spread of those infectious diseases affecting animal husbandry.... |
Collaborative accountability for sustainable public health: A Korean perspective on the effective use of ICT-based health risk communication | Abstract The sustainability of public health practices requires collaboration between the government and its citizens. On the government's side, social media can provide a conduit for communicating health risk information in an effective and timely fashion, while also engaging citizens in informed decision-making. On t... |
Neutrophil-to-lymphocyte ratio and clinical outcome in COVID-19: a report from the Italian front line. | • Clinicians are looking for a reliable prognostic marker for patients with COVID-19; • In our cohort, clinical improvement was predicted by younger age and a NLR below 3; • Transfer to ICU was instead predicted by a NLR over 4 (p=0.046); • NLR is a fast, widely available and relatively inexpensive assessment; • NLR ma... |
A case series of chest imaging manifestation of COVID-19 | Abstract Coronavirus disease 2019 (COVID-19) is caused by a infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [1]. It started in Wuhan, China, in December 2019, after which quickly spread to many other countries around the world. Chest radiography (CXR) and computed tomography (CT) play key ro... |
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