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Prone positioning to improve oxygenation and relieve respiratory symptoms in awake, spontaneously breathing non-intubated patients with COVID-19 pneumonia | Emergency departments are facing an unprecedented challenge in dealing with patients who have coronavirus disease 2019 (COVID-19). The massive number of cases evolving to respiratory failure are leading to a rapid depletion of medical resources such as respiratory support equipment, which is more critical in low- and m... |
HUSBANDRY OF DAIRY ANIMALS | Buffalo: Asia | Domestic buffaloes (Bubalus bubalis) of swamp type (for draught) and river type (for milk) dominate the tropical Asia with slightly more than 169.4 million. They breed throughout the year and produce two calves every 3 years and are fed mainly on straw, crop residues, and mineral supplements. Assisted reproductive tech... |
LUCS: a high-resolution nucleic acid sequencing tool for accurate long-read analysis of individual DNA molecules | Nucleic acid sequence analyses are fundamental to all aspects of biological research, spanning aging, mitochondrial DNA (mtDNA) and cancer, as well as microbial and viral evolution. Over the past several years, significant improvements in DNA sequencing, including consensus sequence analysis, have proven invaluable for... |
Meta-analysis of several epidemic characteristics of COVID-19 | As the COVID-19 pandemic has strongly disrupted people’s daily work and life, a great amount of scientific research has been conducted to understand the key characteristics of this new epidemic. In this manuscript, we focus on four crucial epidemic metrics with regard to the COVID-19, namely the basic reproduction numb... |
Travel, Migration and Emerging Infectious Diseases | Emerging infectious diseases (EID) threaten public health and are sustained by increasing global commerce, travel and disruption of ecological systems. Travelers could play a role in importing EIDs and could be a sentinel of major epidemics. In connection with the extension of poverty, urbanization, extensive livestock... |
Calreticulin as a hydrophilic chimeric molecular adjuvant enhances IgG responses to the spike protein of severe acute respiratory syndrome coronavirus | Fragment 450–650 of the spike (S) protein (S450–650) of severe acute respiratory syndrome‐associated coronavirus (SARS‐CoV) contains epitopes capable of being recognized by convalescent sera of SARS patients. Vaccination of mice with recombinant S450–650 (rS450–650) can induce Abs against SARS‐CoV, although the titer i... |
Transmission Electron Microscopy Studies of Cellular Responses to Entry of Virions: One Kind of Natural Nanobiomaterial | Virions are one kind of nanoscale pathogen and are able to infect living cells of animals, plants, and bacteria. The infection is an intrinsic property of the virions, and the biological process provides a good model for studying how these nanoparticles enter into cells. During the infection, the viruses employ differe... |
Representative Contact Diaries for Modeling the Spread of Infectious Diseases in Taiwan | Recent studies of infectious diseases have attempted to construct more realistic parameters of interpersonal contact patterns from diary-approach surveys. To ensure that such diary-based contact patterns provide accurate baseline data for policy implementation in densely populated Taiwan, we collected contact diaries f... |
On the way to low-dose medicines | |
Has COVID-19 Changed Crime? Crime Rates in the United States during the Pandemic | In response to the COVID-19 pandemic, state-level governments across the United States issued mandatory stay-at-home orders around the end of March 2020. Though intended to stop the spread of the COVID-19 virus, the lockdowns have had sweeping impacts on life in ways which were not originally planned. This study’s purp... |
Proteolytic cleavage of the SARS-CoV-2 spike protein and the role of the novel S1/S2 site | Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 19 (COVID-19) has rapidly spread to the entire world within a few months. The origin of SARS-CoV-2 has been related to the lineage B Betacoronavirus SARS-CoV and SARS-related coronaviruses found in bats. Ea... |
Seroprevalence, cross antigenicity and circulation sphere of bat-borne hantaviruses revealed by serological and antigenic analyses | Bats are newly identified reservoirs of hantaviruses (HVs) among which very divergent HVs have been discovered in recent years. However, their significance for public health remains unclear since their seroprevalence as well as antigenic relationship with human-infecting HVs have not been investigated. In the present s... |
COVID-19: General anesthesia precautions | [Figure: see text] |
Exploiting the Legacy of the Arbovirus Hunters | In recent years, it has become evident that a generational gap has developed in the community of arbovirus research. This apparent gap is due to the dis-investment of training for the next generation of arbovirologists, which threatens to derail the rich history of virus discovery, field epidemiology, and understanding... |
How Do Viruses Avoid Inhibition by Endogenous Cellular MicroRNAs? | |
The SARS Coronavirus 3a Protein Causes Endoplasmic Reticulum Stress and Induces Ligand-Independent Downregulation of the Type 1 Interferon Receptor | The Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) is reported to cause apoptosis of infected cells and several of its proteins including the 3a accessory protein, are pro-apoptotic. Since the 3a protein localizes to the endoplasmic reticulum (ER)-Golgi compartment, its role in causing ER stress was investiga... |
Mortalidad por Covid-19 en pacientes con cáncer en un hospital de Madrid durante las primeras 3 semanas de epidemia | Abstract Background and objective: The Covid-19 pandemic especially affects cancer patients with higher incidence and mortality according to published series of original pandemic foci. The study aims to determine the mortality in our center due to covid-19 in cancer patients during the first 3 weeks of the epidemic. Ma... |
Engineering protein nanocages as carriers for biomedical applications | Protein nanocages have been explored as potential carriers in biomedicine. Formed by the self-assembly of protein subunits, the caged structure has three surfaces that can be engineered: the interior, the exterior and the intersubunit. Therapeutic and diagnostic molecules have been loaded in the interior of nanocages, ... |
Prevalence of Salmonella and E. coli in neonatal diarrheic calves | Abstract Neonatal calf diarrhea remains one of the most important problems faced by livestock, causing great economic losses. This study investigated the prevalence of Salmonella and Escherichia coli, especially enterotoxigenic E. coli (ETEC), in diarrheic calves. Fecal samples were collected from 127 diarrheic calves ... |
Lake retreat: African river valley once hosted big lake | |
Immunological Implications of Physical Inactivity among Older Adults during the COVID-19 Pandemic | Social distancing has been adopted worldwide to control severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission. Social isolation is likely to lead to a decline in physical activity, which could result in immune system dysfunction, thereby increasing infection susceptibility and exacerbating the patho... |
G6PD and chloroquine: Selecting the treatment against SARS‐CoV‐2? | In light of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID-19) pandemic and the possible widespread use of chloroquine (a member of the drug class 4-aminoquinoline primarily used to prevent and treat malaria and amebiasis) and its derivatives (e.g. hydroxychloroquine, a metabolite of chloroqui... |
Postnatal Maturation of Rat Small Intestinal Brush Border Membranes Correlates with Increase in Food Protein Binding Capacity | To investigate maturational changes of membranefood protein binding capacity, we studied bindingcharacteristics of brush border membranes isolated fromsmall intestines of newborn and adult rats. Binding of biotinylated gliadin peptides, cow's milkproteins (α-casein, β-lactoglobulin,α-lactalbumin, bovine serum albumin) ... |
Progress in the Development of Intrinsically Conducting Polymer Composites as Biosensors | Biosensors are analytical devices which find extensive applications in fields such as the food industry, defense sector, environmental monitoring, and in clinical diagnosis. Similarly, intrinsically conducting polymers (ICPs) and their composites have lured immense interest in bio‐sensing due to their various attribute... |
Global approaches for global challenges: The possible support of rehabilitation in the management of COVID‐19 | We have read with interest the paper by Li and colleagues about the neurotropism of the severe acute respiratory syndrome coronavirus (SARS-CoV-2), responsible of coronavirus disease (COVID-19), recently discovered in China and now worldwide spread.1 In particular, the paper focuses on the role of the nervous system in... |
Pflege Markt | |
Sequence Analysis of the Matrix/Nucleocapsid Gene Region of Turkey Coronavirus | A reverse transcriptase, polymerase chain reaction (RT-PCR) procedure was used to amplify a segment of the genome of turkey coronavirus (TCV) spanning portions of the matrix and nucleocapsid (MN) protein genes (approximately 1.1 kb). The MN gene region of three epidemiologically distinct TCV strains (Minnesota, NC95, I... |
The 1977 H1N1 Influenza Virus Reemergence Demonstrated Gain-of-Function Hazards | |
Endowments, foundations shifting strategies to weather pandemic | |
A new protocol for monitoring operational outcomes of environmental management in commercial forestry plantations | Environmental degradation is a global phenomenon with a high likelihood of influencing human quality of life. Effective management responses are needed to achieve societal goals of sustainability. We develop here a new monitoring protocol (Management Check: MATCH) that comprehensively evaluates management outcomes at t... |
Interleukin-17 suppresses grass carp reovirus infection in Ctenopharyngodon idellus kidney cells by activating NF-κB signaling | Abstract The grass carp accounts for a large proportion of aquacultural production in China, but the hemorrhagic disease caused by grass carp reovirus (GCRV) infection often causes huge economic losses to the industry. Interleukin 17 (IL-17) is an important cytokine that plays a critical role in the inflammatory and im... |
Post-pandemic influenza A/H1N1pdm09 is associated with more severe outcomes than A/H3N2 and other respiratory viruses in adult hospitalisations | This study compares the frequency and severity of influenza A/H1N1pdm09 (A/H1), influenza A/H3N2 (A/H3) and other respiratory virus infections in hospitalised patients. Data from 17 332 adult hospitalised patients admitted to Sir Charles Gairdner Hospital, Perth, Western Australia, with a respiratory illness between 20... |
siVirus: web-based antiviral siRNA design software for highly divergent viral sequences | siVirus () is a web-based online software system that provides efficient short interfering RNA (siRNA) design for antiviral RNA interference (RNAi). siVirus searches for functional, off-target minimized siRNAs targeting highly conserved regions of divergent viral sequences. These siRNAs are expected to resist viral mut... |
Will neurological care change over the next 5 years due to the COVID-19 pandemic? | Abstract Introduction The COVID-19 pandemic will give rise to long-term changes in neurological care, which are not easily predictable. Material and methods A key informant survey was used to enquire about the changes expected in the specialty over the next 5 years. The survey was completed by heads of neurology depart... |
Metagenomic Investigation of Idiopathic Meningoencephalomyelitis in Dogs | BACKGROUND: Meningoencephalomyelitis of unknown origin (MUO) is a common and life‐threatening neuroinflammatory disease in dogs. Features of the disease are suggestive of an underlying immune‐mediated process, but the association of this disease with a pathogen is still unknown. HYPOTHESIS/OBJECTIVES: To search for can... |
Glycyrrhizin Exerts Antioxidative Effects in H5N1 Influenza A Virus-Infected Cells and Inhibits Virus Replication and Pro-Inflammatory Gene Expression | Glycyrrhizin is known to exert antiviral and anti-inflammatory effects. Here, the effects of an approved parenteral glycyrrhizin preparation (Stronger Neo-Minophafen C) were investigated on highly pathogenic influenza A H5N1 virus replication, H5N1-induced apoptosis, and H5N1-induced pro-inflammatory responses in lung ... |
Small-area spatial statistical analysis of malaria clusters and hotspots in Cameroon;2000–2015 | BACKGROUND: Malaria prevalence in Cameroon is a major public health problem both at the regional and urban-rural geographic scale. In 2016, an estimated 1.6 million confirmed cases, and 18,738 cases were reported in health facilities and communities respectively, with about 8000 estimated deaths. Several studies have e... |
The Utility of rRT-PCR in Diagnosis and Assessment of Case-fatality rates of COVID-19 In the Iranian Population. Positive Test Results are a Marker for Illness Severity | The utility of PCR-based testing in characterizing patients with COVID-19 and the severity of their disease remains unknown. We performed an observational study among patients presenting to hospitals in Iran who were tested for 2019-nCoV viral RNA by rRT-PCR between the fourth week of February 2020 to the fourth week o... |
The musings of a family therapist in Asia when COVID‐19 struck | In response to the COVID‐19 crisis in Asia, a family therapist in Hong Kong shares her experiences and reflections, both personally and professionally from an Eastern lens. From a state of shock and immobilization to moments of contemplation, she highlights her struggle with being caught between her Eastern roots and W... |
A systematic review of the active saikosaponins and extracts isolated from Radix Bupleuri and their applications | Context: Radix Bupleuri has been used in traditional Chinese medicine for over 2000 years with functions of relieving exterior syndrome, clearing heat, regulating liver-qi, and lifting yang-qi. More natural active compounds, especially saikosaponins, have been isolated from Radix Bupleuri, which possess various valuabl... |
Epidemiological and clinical characteristics of 671 COVID-19 patients in Henan Province, China | BACKGROUND: Despite many reports on the characteristics of coronavirus disease 2019 (COVID-19) in Wuhan, China, relatively little is known about the transmission features of COVID-19 outside Wuhan, especially at the provincial level. METHODS: We collected epidemiological, demographic, clinical, laboratory, radiological... |
Infection control practices in children during COVID-19 pandemic: differences from adults | BACKGROUND: Limited studies have been published on practices and management of COVID-19 in children. Despite the fact that COVID-19 rarely caused any severe disease in children, the asymptomatic children might be playing an important role for spreading COVID-19 in healthcare facilities. This review aimed at sharing our... |
Tuberculosis infection and epidemiological characteristics in Haidian District, Beijing, 2005–2018 | BACKGROUND: This study was aimed to investigate the epidemiological characteristic of pulmonary tuberculosis (PTB) in Haidian District, Beijing from 2005 to 2018 and to provide suggestions for controlling tuberculosis (TB) development. METHODS: Epidemiological data about TB were obtained by the Infectious Disease Repor... |
Clinical characteristics of eosinophilic asthma exacerbations | BACKGROUND AND OBJECTIVE: Airway eosinophilia is associated with an increased risk of asthma exacerbations; however, the impact on the severity of exacerbations is largely unknown. We describe the sputum inflammatory phenotype during asthma exacerbation and correlate it with severity and treatment response. METHODS: Pa... |
Protein synthesis in cells infected by murine hepatitis viruses JHM and A59: Tryptic peptide analysis | The structural and intracellular proteins of the murine hepatitis viruses MHV-JHM and MHV-A59 were studied by tryptic peptide mapping. The results demonstrated that the virions contained three distinct proteins: the two related chains of the E2 complex, the nucleocapsid protein and the heterogeneous E1 complex. Five di... |
Going batty: Studying natural reservoirs to inform drug development | |
Erupción medicamentosa en paciente infectado por SARS-CoV2 | |
Rethinking the role of hydroxychloroquine in the treatment of COVID‐19 | There are currently no proven or approved treatments for coronavirus disease 2019 (COVID‐19). Early anecdotal reports and limited in vitro data led to the significant uptake of hydroxychloroquine (HCQ), and to lesser extent chloroquine (CQ), for many patients with this disease. As an increasing number of patients with ... |
Role of Natural Killer and Gamma-Delta T cells in West Nile Virus Infection | Natural Killer (NK) cells and Gamma-delta T cells are both innate lymphocytes that respond rapidly and non-specifically to viral infection and other pathogens. They are also known to form a unique link between innate and adaptive immunity. Although they have similar immune features and effector functions, accumulating ... |
Phylogeography, Transmission, and Viral Proteins of Nipah Virus | Nipah virus (NiV), a zoonotic paramyxovirus belonging to the genus Henipavirus, is classified as a Biosafety Level-4 pathogen based on its high pathogenicity in humans and the lack of available vaccines or therapeutics. Since its initial emergence in 1998 in Malaysia, this virus has become a great threat to domestic an... |
Significant Transplantation-Related Mortality from Respiratory Virus Infections within the First One Hundred Days in Children after Hematopoietic Stem Cell Transplantation | Abstract Respiratory viral infections (RVI) are important in hematopoietic stem cell transplantations (HSCT) and knowledge regarding incidence, morbidity, mortality, and long-term pulmonary complications is limited. We report a study to evaluate incidence and outcomes, both short and long-term, of RVI in children recei... |
Inhibition of metalloproteinases in therapy for severe lung injury due to COVID-19 | Since its first appearance in December 2019 in the Chinese province of Wuhan, COVID-19 has spread rapidly throughout the world and poses a serious threat to public health. Acute respiratory failure due to widespread lung inflammation progress to acute respiratory distress syndrome (ARDS) with an altered pulmonary and a... |
Database and Analytical Resources for Viral Research Community | Abstract Many public databases and analytical resources are available to facilitate virology research. The Virus Pathogen Database and Analysis Resource (ViPR, see “Relevant Websites section”) and Influenza Research Database (IRD, see “Relevant Websites section”) are comprehensive and highly curated repositories of gen... |
COVID‐19 and ectodermal dysplasias. Recommendations are necessary | |
The association between obesity, type 2 diabetes, and hypertension with severe COVID‐19 on admission among Mexicans | OBJECTIVE: To explore the association between obesity, type 2 diabetes, hypertension, and severe COVID‐19 on admission. METHODS: In the present study, a total of 23,593 patient samples were evaluated by a laboratory from the Mexican Institute of Epidemiological Diagnosis and Reference (InDRE, for its acronym in Spanish... |
Modular approach to customise sample preparation procedures for viral metagenomics: a reproducible protocol for virome analysis | A major limitation for better understanding the role of the human gut virome in health and disease is the lack of validated methods that allow high throughput virome analysis. To overcome this, we evaluated the quantitative effect of homogenisation, centrifugation, filtration, chloroform treatment and random amplificat... |
PRED(BALB/c): a system for the prediction of peptide binding to H2(d) molecules, a haplotype of the BALB/c mouse | PRED(BALB/c) is a computational system that predicts peptides binding to the major histocompatibility complex-2 (H2(d)) of the BALB/c mouse, an important laboratory model organism. The predictions include the complete set of H2(d) class I (H2-K(d), H2-L(d) and H2-D(d)) and class II (I-E(d) and I-A(d)) molecules. The pr... |
Identification of effective siRNA blocking the expression of SARS viral envelope E and RDRP genes | A cell-based assay was developed to screen small interference RNA (siRNA) to block the expression of two genes of the severe acute respiratory syndrome (SARS) virus. These two genes encode RNA-dependent RNA polymerase (RDRP) and envelope E protein. The RDRP plays an essential role in viral RNA replication where envelop... |
Deletion of accessory genes 3a, 3b, 5a or 5b from avian coronavirus infectious bronchitis virus induces an attenuated phenotype both in vitro and in vivo | Avian coronavirus infectious bronchitis virus (IBV) infects domestic fowl, resulting in respiratory disease and causing serious losses in unprotected birds. Its control is mainly achieved by using live attenuated vaccines. Here we explored the possibilities for rationally attenuating IBV to improve our knowledge regard... |
Potential Ebola prophylaxis | |
Evaluation of knowledge and attitudes among intensive care physicians during the COVID-19 pandemic: a cross-sectional survey | BACKGROUND: The novel coronavirus (COVID-19) emerged in Wuhan, China, in December 2019 OBJECTIVES: To evaluate the knowledge of intensive care physicians in Turkey about COVID-19 and their attitudes towards the strategies and application methods to be used for COVID-19 cases that need to be followed up in an intensive ... |
REPLY to: Labor and Delivery Guidance for COVID-19 | |
Porcine epidemic diarrhoea: new insights into an old disease | Porcine epidemic diarrhea (PED) is an enteric disease in swine caused by an alphacoronavirus. It affects swine of all ages causing acute diarrhoea and can lead to severe dehydration and death in suckling piglets. Being recognized for the first time in Europe and Asia during the seventies and the eighties, respectively,... |
Protein covariance networks reveal interactions important to the emergence of SARS coronaviruses as human pathogens | SARS-CoV-2 is one of three recognized coronaviruses (CoVs) that have caused epidemics or pandemics in the 21st century and that have likely emerged from animal reservoirs based on genomic similarities to bat and other animal viruses. Here we report the analysis of conserved interactions between amino acid residues in p... |
Comparison of two multiplexed PCR assays for respiratory virus detection in ICU patients: FilmArray® respiratory panel and Allplex™ respiratory full panel | |
Biosafety and data quality considerations for animal experiments with highly infectious agents at ABSL-3 facilities | Abstract Animal models are crucial for the study of severe infectious diseases, which is essential for determining their pathogenesis and the development of vaccines and drugs. Animal experiments involving risk grade 3 agents such as SARS CoV, HIV, M.tb, H7N9, and Brucella must be conducted in an Animal Biosafety Level... |
SARS-CoV-2 (COVID-19) and intravascular volume management strategies in the critically ill | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread across the globe, and millions of people may be affected. While knowledge regarding epidemiologic features and diagnostic tools of coronavirus disease 2019 (COVID-19) is rapidly evolving, uncertainties surrounding various aspects of it... |
Lessons learned so far from the pandemic: A review on pregnants and neonates with COVID-19 | There are concerns regarding the risk and the course of COVID-19 in pregnancy and in the neonates. In this review, we aimed to present the current understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy and neonatal periods considering diagnosis, treatment, prognosis, an... |
CD4 T(RM) Cells Following Infection and Immunization: Implications for More Effective Vaccine Design | The induction of immunological memory, which is mediated by memory T and B cells, is central to adaptive protective immunity to pathogens induced by previous infection and is the cornerstone of effective vaccine design. Recent studies in mice have suggested that memory T cells that accumulate in tissues, termed tissue-... |
Comparative genomics of QX-like infectious bronchitis viruses in Korea | To minimize the spread of infectious bronchitis virus (IBV), domestic fowl have been extensively vaccinated with the KM91 strain. However, various IBV QX-like virus strains have become increasingly prevalent in Korea. We conducted comparative genomic analyses of seven QX-like viruses: early viruses (n = 2), new cluster... |
The Effect of COVID-19 on Youth Mental Health | The purposes of this study was to assess the youth mental health after the coronavirus disease 19 (COVID-19) occurred in China two weeks later, and to investigate factors of mental health among youth groups. A cross-sectional study was conducted two weeks after the occurrence of COVID-19 in China. A total of 584 youth ... |
Subcutaneous Implants of a Cholesterol-Triglyceride-Buprenorphine Suspension in Rats | A Target Animal Safety protocol was used to examine adverse events in male and female Fischer F344/NTac rats treated with increasing doses of a subcutaneous implant of a lipid suspension of buprenorphine. A single injection of 0.65 mg/kg afforded clinically significant blood levels of drug for 3 days. Chemistry, hemato... |
Rinitis agudas | Resumen La rinitis aguda es la afección rinológica más frecuente. El costo económico de los tratamientos y el absentismo laboral que provoca esta patología tienen una repercusión socioeconómica muy importante. En su forma habitual, de etiología viral, esta afección se resuelve espontáneamente en varios días. Las recidi... |
Chapter 5 ZMapp The Ethics of Decision Making | Abstract Ebola’s Curse: 2013–2016 Outbreak in West Africa, a timely, needed and well-presented book by Michael Oldstone and Madeleine Rose Oldstone, unlocks the mysteries of the largest outbreak of one of the world’s most fearsome viruses. What is Ebola? Why did this happen? Here you will find the answers to these ques... |
COVID 19 and Brain Crosstalks | |
Using cellular automata images and pseudo amino acid composition to predict protein subcellular location | The avalanche of newly found protein sequences in the post-genomic era has motivated and challenged us to develop an automated method that can rapidly and accurately predict the localization of an uncharacterized protein in cells because the knowledge thus obtained can greatly speed up the process in finding its biolog... |
Post‐SARS sickness syndrome manifestations and endocrinopathy: how, why, and so what? | |
SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic Reticulum | Positive-strand RNA viruses, a large group including human pathogens such as SARS-coronavirus (SARS-CoV), replicate in the cytoplasm of infected host cells. Their replication complexes are commonly associated with modified host cell membranes. Membrane structures supporting viral RNA synthesis range from distinct spher... |
Genetic variability: The key problem in the prevention and therapy of RNA‐based virus infections | Despite extraordinary progress that has recently been made in biomedical sciences, viral infectious diseases still remain one of the most serious world health problems. Among the different types of viruses, those using RNA as their genetic material (RNA viruses and retroviruses) are especially dangerous. At present the... |
Validation of a multiplex reverse transcriptase PCR ELISA for the detection of 19 respiratory tract pathogens | INTRODUCTION: Since acute respiratory tract infections inflict a high burden of disease in children worldwide, a multiplex reverse transcription polymerase chain reaction combined with a microwell hybridization assay (m-RT-PCR–ELISA) to detect 19 different respiratory pathogens was developed and validated. METHODS: A t... |
Bilateral orbital and nasal aspergillosis in a cat | A 12‐year‐old, 4 kg, castrated male Persian cat was referred with a 2‐month history of sneezing and bilateral mucopurulent nasal discharge. Rhinoscopically acquired nasal biopsies at this time revealed bilateral lymphoplasmacytic rhinitis. A tapering dose of oral prednisone caused the complete remission of the clinical... |
Examining structural changes in Asian offices market | It is complicated to measure the effects of various economic events on office markets within a non-parameter modeling framework. In response to this issue, a non-parametric statistical method-wavelet analysis is introduced in this study. Based on this innovative technique, we not only could detect the abrupt change poi... |
Genome-wide analysis of Indian SARS-CoV-2 genomes for the identification of genetic mutation and SNP | The wave of COVID-19 is a big threat to the human population. Presently, the world is going through different phases of lock down in order to stop this wave of pandemic; India being no exception. We have also started the lock down on 23rd March 2020. In this current situation, apart from social distancing only a vaccin... |
Provision of cancer care during the COVID-19 pandemic | Health-care services are rapidly transforming their organization and workforce in response to the coronavirus disease 2019 (COVID-19) pandemic. These changes, and a desire to mitigate infection risk, are having profound effects on other vital aspects of care, including the care of patients with cancer. Difficult decisi... |
Special attention to nurses’ protection during the COVID-19 epidemic | As of March 8, 2020, the novel coronavirus disease 2019 (COVID-19) had caused 80,815 human infections and 3073 deaths in China, including more than 3000 infections among medical staff. Guangdong Second Provincial General Hospital (Guangzhou, Guangdong Province, China), a provincial emergency hospital, has treated more ... |
First Detection of Canine Parvovirus Type 2c in Pups with Haemorrhagic Enteritis in Spain | Canine parvovirus type 2 (CPV‐2), the aetiological agent of haemorrhagic enteritis in dogs, includes three antigenic variants, types 2a, 2b and 2c. CPV‐2c has been detected initially in Italy and subsequently in Vietnam. We report the first identification of this novel antigenic variant in Spain, where it caused an out... |
Poly(I:C) promotes TNFα/TNFR1-dependent oligodendrocyte death in mixed glial cultures | BACKGROUND: Activation of glial cells via toll-like receptors (TLRs) and other intracellular pathogen recognition receptors promotes the release of potentially toxic acute phase reactants such as TNFα and nitric oxide into the extracellular space. As such, prolonged glial activation, as is thought to occur during a per... |
Women’s Health During the COVID-19 Surge in the Bronx: Reflections from Two OBGYNs on the Flatter Side of the Curve | |
“Masked” empathy‐ a post‐pandemic reality: Psychodermatological perspective | |
Community health workers in Ghana: the need for greater policy attention | From the 1970s to the 1990s, the WHO, United Nations and other agencies mooted the idea of formally training and recognising community health workers (CHWs) to complement efforts to improve primary healthcare delivery in low and middle income countries. Recently, CHWs have been recognised as important players in the ac... |
Viral Infections in Children in the 2014/2015 Epidemic Season in Poland | In every epidemic season, viral infections affect the general population, including children, which is an underestimated issue. The present study demonstrates the results of examination of 802 clinical samples obtained from pediatric patients aged 0–14 years during the 2014/2015 epidemic season in Poland. The study was... |
Seaweed Secondary Metabolites with Beneficial Health Effects: An Overview of Successes in In Vivo Studies and Clinical Trials | Macroalgae are increasingly viewed as a source of secondary metabolites with great potential for the development of new drugs. In this development, in vitro studies are only the first step in a long process, while in vivo studies and clinical trials are the most revealing stages of the true potential and limitations th... |
Managing Emerging Infectious Diseases: Should Travel Be the Fifth Vital Sign? | In the setting of emerging infections, such as COVID-19, this commentary argues that all members of the health care team need training on how to integrate key epidemiologic information, such as travel history, into their risk assessments in the same way they are trained to ask about tobacco exposure to assess cancer an... |
Coronavirus disease 2019 (COVID-19): challenges and management of aerosol-generating procedures in dentistry | Data sources Experimental investigation. Study design A retrospective review to evaluate the use of a negative-pressure otolaryngology viral isolation drape (NOVID) system to reduce cross-infection through aerosol. The apparatus consists of a plastic drape suspended over the surgical field in the head and neck region w... |
A comparative study on the time to achieve negative nucleic acid testing and hospital stays between Danoprevir and Lopinavir/Ritonavir in the treatment of patients with COVID‐19 | BACKGROUND: In late December 2019, the coronavirus disease 2019 (COVID‐19) first outbroke in Wuhan city, China, and has now become a global pandemic. However, there is no specific antiviral treatment for COVID‐19. METHODS: This study enrolled 33 COVID‐19 patients in the nineth hospital of Nanchang from January 27(th) t... |
Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC | Most human coronaviruses cause mild upper respiratory tract disease but may be associated with more severe pulmonary disease in immunocompromised individuals(1). However, SARS coronavirus caused severe lower respiratory disease with nearly 10% mortality and evidence of systemic spread(2). Recently, another coronavirus ... |
COVID-19 pandemic preparedness: A practical guide from an operational pharmacy perspective | PURPOSE: To describe our medical center’s pharmacy services preparedness process and offer guidance to assist other institutions in preparing for surges of critically ill patients such as those experienced during the coronavirus disease 2019 (COVID-19) pandemic. SUMMARY: The leadership of a department of pharmacy at an... |
Chapter 4 Emergence in the functionalized carbon nanotubes as smart nanocarriers for drug delivery applications | Abstract Carbon nanotubes (CNTs) are the newer generation advanced materials for diverse applications, starting from physical, mechanical, chemical and biological sciences. However, the present era of healthcare industry is extensively using CNTs for exploring their applications in mitigating diverse needs. The conside... |
Reduction in emergency surgery activity during COVID‐19 pandemic in three Spanish hospitals | |
Inhibition of RNA Recruitment and Replication of an RNA Virus by Acridine Derivatives with Known Anti-Prion Activities | BACKGROUND: Small molecule inhibitors of RNA virus replication are potent antiviral drugs and useful to dissect selected steps in the replication process. To identify antiviral compounds against Tomato bushy stunt virus (TBSV), a model positive stranded RNA virus, we tested acridine derivatives, such as chlorpromazine ... |
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