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Small molecules with antiviral activity against the Ebola virus | The recent outbreak of the Ebola virus in West Africa has highlighted the clear shortage of broad-spectrum antiviral drugs for emerging viruses. There are numerous FDA approved drugs and other small molecules described in the literature that could be further evaluated for their potential as antiviral compounds. These m... |
The expanding roles of endoplasmic reticulum stress in virus replication and pathogenesis | The endoplasmic reticulum (ER) is a cellular membrane organelle that plays important roles in virus replication and maturation. Accumulating evidence indicates that virus infection often disturbs ER homeostasis and leads to ER stress, which is associated with a variety of prevalent diseases. To cope with the deleteriou... |
Antiviral Agents☆ | Abstract Antiviral agents are drugs approved in the USA by the Food and Drug Administration (FDA) for the treatment or control of viral infections. Available antiviral agents mainly target stages in the viral life cycle. The target stages in the viral life cycle are; viral attachment to host cell, uncoating, synthesis ... |
A global perspective on hepatitis B‐related single nucleotide polymorphisms and evolution during human migration | Genome‐wide association studies have indicated that human leukocyte antigen (HLA)‐DP and HLA‐DQ play roles in persistent hepatitis B virus (HBV) infection in Asia. To understand the evolution of HBV‐related single nucleotide polymorphisms (SNPs) and to correlate these SNPs with chronic HBV infection among different pop... |
Search for Therapeutics Continues as SARS ‘Epidemic’ Abates | |
What do monitoring platelet counts in COVID‐19 teach us? | Yang and colleagues published the relevance of thrombocytopenia in COVID-19 patients and its association with mortality in this condition in the Journal of Thrombosis and Haemostasis.1 The authors are to be applauded for the largest so-far analysis in the epidemiology of thrombocytopenia in patients with COVID-19. In a... |
Heat-Related Deaths — United States, 2004–2018 | Deaths attributable to natural heat exposure, although generally considered preventable (1), represent a continuing public health concern in the United States. During 2004-2018, an average of 702 heat-related deaths occurred in the United States annually. To study patterns in heat-related deaths by age group, sex, race... |
One-step nanomorphology control of self-organized projection coronas in uniform polymeric nanoparticles | Abstract Uniform polymeric nanoparticles with various morphologies of projection coronas like the viruses in the coronavirus group have been formed by the self-organization of macromolecular chains polymerizing in a dispersion system of styrene (St), acrylonitrile (AN) and poly(ethylene glycol) monomethoxymonomethacryl... |
Public enemy number one | The new coronavirus is no small threat, but we are starting to understand how it works, reports Michael Marshall |
A Review on Applications of Computational Methods in Drug Screening and Design | Drug development is one of the most significant processes in the pharmaceutical industry. Various computational methods have dramatically reduced the time and cost of drug discovery. In this review, we firstly discussed roles of multiscale biomolecular simulations in identifying drug binding sites on the target macromo... |
Antioxidant potential of theaflavin ameliorates the activities of key enzymes of glucose metabolism in high fat diet and streptozotocin – induced diabetic rats | Objectives: The present study was to evaluate the effect of theaflavin on the activities of key enzymes of carbohydrate metabolism in high fat diet and streptozotocin – induced diabetic rats. Methods: Diabetes was induced in male albino Wistar rats by feeding them with high fat diet comprising of standard laboratory ra... |
Repercussions of COVID-19 pandemic on municipal solid waste management: Challenges and opportunities | Abstract The COVID-19 pandemic has caused global emergency and has raised social and economic concerns which will also spill over to environmental issues. Amid this natural experiment, current study evaluates prevailing municipal solid waste (MSW) management practices, with the emphasis on MSW treatment and disposal fa... |
Xylem supports community-based responses to Covid-19 | Xylem has extended its Partner Community Grants Program to support community-level responses to Covid-19. |
Susceptibility of Southwestern American Indian Tribes to Coronavirus Disease 2019 (COVID‐19) | |
Clinical Development of a Cytomegalovirus DNA Vaccine: From Product Concept to Pivotal Phase 3 Trial | 2013 marks a milestone year for plasmid DNA vaccine development as a first-in-class cytomegalovirus (CMV) DNA vaccine enters pivotal phase 3 testing. This vaccine consists of two plasmids expressing CMV antigens glycoprotein B (gB) and phosphoprotein 65 (pp65) formulated with a CRL1005 poloxamer and benzalkonium chlori... |
Pseudomonas aeruginosa infection increases the readmission rate of COPD patients | INTRODUCTION: Acute exacerbation of COPD (AECOPD) leads to rapid deterioration of pulmonary function and quality of life. It is unclear whether the prognosis for AECOPD differs depending on the bacterium or virus identified. The purpose of this study is to determine whether readmission of patients with severe AECOPD va... |
Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets | The ubiquitin–proteasome system (UPS) and ubiquitin-like protein (UBL) conjugation pathways are integral to cellular protein homeostasis. The growing recognition of the fundamental importance of these pathways to normal cell function and in disease has prompted an in-depth search for small-molecule inhibitors that sele... |
New opportunities for the redesign of agricultural and food systems | |
Definition of an extended MHC class II-peptide binding motif for the autoimmune disease-associated Lewis rat RT1.BL molecule. | The Lewis rat, an inbred rat strain susceptible to several well-characterized experimental autoimmune diseases, provides a good model to study peptide-mediated immunotherapy. Peptide immunotherapy focussing on the modulation of T cell responses by interfering with TCR-peptide-MHC complex formation requires the elucidat... |
Cameroonian fruit bats harbor divergent viruses, including rotavirus H, bastroviruses, and picobirnaviruses using an alternative genetic code | Most human emerging infectious diseases originate from wildlife and bats are a major reservoir of viruses, a few of which have been highly pathogenic to humans. In some regions of Cameroon, bats are hunted and eaten as a delicacy. This close proximity between human and bats provides ample opportunity for zoonotic event... |
COVID ‐19 and medical staff's mental health in educational hospitals in Alborz province, Iran | |
Combined use of the neutrophil-to-lymphocyte ratio and CRP to predict 7-day disease severity in 84 hospitalized patients with COVID-19 pneumonia: a retrospective cohort study. | Background Coronavirus disease 2019 (COVID-19) has spread rapidly worldwide from Wuhan. An easy-to-use index capable of the early identification of inpatients who are at risk of becoming critically ill is urgently needed in clinical practice. Hence, the aim of this study was to explore an easy-to-use nomogram and a mod... |
Making of Viral Replication Organelles by Remodeling Interior Membranes | Positive-stranded RNA (+RNA) viruses exploit host cell machinery by subverting host proteins and membranes and altering cellular pathways during infection. To achieve robust replication, some +RNA viruses, such as poliovirus (PV), build special intracellular compartments, called viral replication organelles. A recent w... |
Clinical features of children hospitalized with influenza A and B infections during the 2012–2013 influenza season in Italy | BACKGROUND: Influenza is a major public health issue worldwide. It is characterized by episodes of infection that involve hundreds of millions of people each year. Since that in the seasons 2010–2011 and 2011–2012 the circulation of FLUB was decreasing we evaluated the clinical presentation, demographic characteristics... |
The origin of acute respiratory epidemics | After studying the dependence of acute respiratory diseases of all etiologies on air temperature and population immunity dynamics, the authors proposed that the air temperature and the immunity level can affect disease resistance. Knowledge of the relationship between these factors must clarify the mechanisms that dete... |
Community-Acquired Respiratory Viruses | The incidence of community-acquired respiratory viruses (CARVs) is ∼15 cases per 100 patient-years after lung transplantation (LTx). Paramyxoviruses account for almost 50% of the cases of CARV infection in LTx. Most patients will be symptomatic with a mean decline of 15 to 20% in forced expiratory volume in 1 second. T... |
Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity | For many emerging and re-emerging infectious diseases, definitive solutions via sterilizing adaptive immunity may require years or decades to develop, if they are even possible. The innate immune system offers alternative mechanisms that do not require antigen-specific recognition or a priori knowledge of the causative... |
Virion glycosylation governs integrity and infectivity of infectious pancreatic necrosis virus | The possible importance of the O‐linked glycosylation in virion stability and infectivity of infectious pancreatic necrosis virus (IPNV) was analysed. Enzymatic treatment with O‐glycosidase of radiolabelled virions under different ionic conditions, to allow for possible alternative exposure of glycosidic enzyme cleavag... |
Macrothrombosis and stroke in patients with mild Covid‐19 infection | Coronavirus disease 2019 (COVID‐19) is a pandemic disease currently affecting millions of people worldwide. Its neurological implications are poorly understood, and further study is urgently required. A hypercoagulable state has been reported in patients with severe COVID‐19, but nothing is known about coagulopathy in ... |
Examining the Moderation Effect of Political Trust on the Linkage between Civic Morality and Support for Environmental Taxation | Climate change and pollution are threatening sustainable environments and human life. To mitigate and adapt to the effects of such threats, governments around the world need significant financial resources. Accordingly, this study focuses on which factors are associated with individuals’ support for taxation to protect... |
Human papillomavirus: The other invisible enemy | • The world is working with unprecedented fervor and spending billions of dollars to find a vaccine for COVID-19. • Nearly 381,500 people worldwide died from human papillomavirus-related cancers in 2018 despite a safe and effective vaccine. • With the momentum from our fight against this pandemic, we can improve vaccin... |
Genome Organization of the SARS-CoV | Annotation of the genome sequence of the SARS-CoV (severe acute respiratory syndrome-associated coronavirus) is indispensable to understand its evolution and pathogenesis. We have performed a full annotation of the SARS-CoV genome sequences by using annotation programs publicly available or developed by ourselves. Tota... |
Maintenance of PD-1 on brain-resident memory CD8 T cells is antigen-independent | Infection of the central nervous system by murine polyomavirus (MuPyV), a persistent natural mouse pathogen, establishes brain-resident memory CD8 T cells (bT(RM)) that uniformly and chronically express PD-1 irrespective of expression of the α(E) integrin CD103, a T(RM) cell marker. In contrast, memory antiviral CD8 T ... |
“SARS-CoV-2 in the peritoneal waste of patients treated with peritoneal dialysis” | |
Cardiopulmonary resuscitation of inpatients with severe COVID-19 pneumonia: the Wuhan experience | |
Impact of Social Vulnerability on COVID-19 Incidence and Outcomes in the United States | Importance: Prior pandemics have disparately affected socially vulnerable communities. Whether regional variations in social vulnerability to disasters influence COVID-19 outcomes and incidence in the U.S. is unknown. Objective: To examine the association of Social Vulnerability Index (SVI), a percentile-based measure ... |
COVID-19 stressors on migrant workers in Kuwait: cumulative risk considerations | As a marginalised subpopulation, migrant workers often fall short from protection by public policies, they take precarious jobs with unsafe working and living conditions and they grapple with cultural and linguistic barriers. In light of the current COVID-19 pandemic, migrant workers are now exposed to additional stres... |
What is new in otitis media? | The “wait and see” approach in acute otitis media (AOM), consisting of postponing the antibiotic administration for a few days, has been advocated mainly to counteract the increased bacterial resistance in respiratory infections. This approach is not justified in children less than 2 years of age and this for several r... |
Chikungunya Fever, Hong Kong | |
Characterisation of porcine epidemic diarrhea virus isolates during the 2014–2015 outbreak in the Philippines | The viral agent of the porcine epidemic diarrhea (PED) was investigated during the reported 2014–2015 outbreaks in commercial farms in Central Luzon, Philippines. The study covered detection of PED virus (PEDV) in fecal and intestinal samples through reverse transcription PCR and sequence analysis of the nucleocapsid (... |
Epidemiology of Injuries Sustained by Civilians and Local Combatants in Contemporary Armed Conflict: An Appeal for a Shared Trauma Registry Among Humanitarian Actors | BACKGROUND: Conflict-related injuries sustained by civilians and local combatants are poorly described, unlike injuries sustained by US, North Atlantic Treaty Organization, and coalition military personnel. An understanding of injury epidemiology in twenty-first century armed conflict is required to plan humanitarian t... |
Lonicerae japonicae flos and Lonicerae flos: a systematic review of ethnopharmacology, phytochemistry and pharmacology | Lonicerae japonicae flos (called Jinyinhua, JYH in Chinese), flowers or flower buds of Lonicera japonica Thunberg, is an extremely used traditional edible-medicinal herb. Pharmacological studies have already proved JYH ideal clinical therapeutic effects on inflammation and infectious diseases and prominent effects on m... |
Technology‐based management of neurourology patients in the COVID‐19 pandemic: Is this the future? A report from the International Continence Society (ICS) institute | Coronavirus disease‐2019 (COVID‐19) pandemic significantly altered our daily life as well as our professional practice. COVID‐19 has disrupted our lives both professionally and personally. We know the urological management in a neurogenic patient needs to be tailored to the individual circumstances, this is even more p... |
“The COVID-19 Generation”: A Cautionary Note | With COVID-19 presenting as a global pandemic, we have noticed an emerging rhetoric concerning “the COVID-19 Generation,” both anecdotally and across various media outlets. The narratives advanced to support such rhetoric have distinct implications for the study of work, aging, and retirement. In this commentary, we re... |
Part 2 model eye simulation: aerosol generating procedures in intraocular surgery | |
Establishment and Clinical Applications of a Portable System for Capturing Influenza Viruses Released through Coughing | Coughing plays an important role in influenza transmission; however, there is insufficient information regarding the viral load in cough because of the lack of convenient and reliable collection methods. We developed a portable airborne particle-collection system to measure the viral load; it is equipped with an air sa... |
Levodopa attenuates cellular apoptosis in steroid-associated necrosis of the femoral head | The present study aimed to investigate the effects of levodopa (LEV) on cellular apoptosis in a rabbit model of steroid-associated necrosis of the femoral head (SANFH). A total of 44 healthy adult Chinese rabbits were randomly divided into three groups: Group A (n=15), administered a combination of lipopolysaccharide a... |
Automatisches Pollenmonitoring in Deutschland: Eine Arbeit der Sektion Umwelt- und Arbeitsmedizin der Deutschen Gesellschaft für Allergologie und klinische Immunologie (DGAKI) | |
Coronavirus Associated Fulminant Myocarditis Successfully Treated With Intravenous Immunoglobulin and Extracorporeal Membrane Oxygenation | |
COVID-19 and telepsychiatry: Early outpatient experiences and implications for the future | The COVID-19 pandemic has dramatically transformed the U.S. healthcare landscape. Within psychiatry, a sudden relaxing of insurance and regulatory barriers during the month of March 2020 enabled clinicians practicing in a wide range of settings to quickly adopt virtual care in order to provide critical ongoing mental h... |
Natural selection and infectious disease in human populations | The ancient biological 'arms race' between microbial pathogens and humans has shaped genetic variation in modern populations, and this has important implications for the growing field of medical genomics. As humans migrated throughout the world, populations encountered distinct pathogens, and natural selection increase... |
Artículo EspecialEl médico frente a la COVID-19: lecciones de una pandemia | Abstract Apart from its enormous health and economic impact, the COVID-19 pandemic has changed the way of practicing medicine and medical education. It is likely that this effect may accelerate the transformation that both activities are experiencing. The present article, written at the peak of the crisis, sets out som... |
Risk factors for disease severity, unimprovement, and mortality of COVID-19 patients in Wuhan, China | Abstract Objective Since December 2019, coronavirus disease (COVID-19) emerged in Wuhan. However, the characteristics and risk factors associated with disease severity, unimprovement and mortality are unclear. Methods All consecutive patients diagnosed with COVID-19 admitted to the Renmin Hospital of Wuhan University f... |
Influence of extreme weather and meteorological anomalies on outbreaks of influenza A (H1N1) | Biological experiments and epidemiological evidence indicate that variations in environment have important effect on the occurrence and transmission of epidemic influenza. It is therefore important to understand the characteristic patterns of transmission for prevention of disease and reduction of disease burden. Based... |
SKEMPI 2.0: an updated benchmark of changes in protein–protein binding energy, kinetics and thermodynamics upon mutation | MOTIVATION: Understanding the relationship between the sequence, structure, binding energy, binding kinetics and binding thermodynamics of protein–protein interactions is crucial to understanding cellular signaling, the assembly and regulation of molecular complexes, the mechanisms through which mutations lead to disea... |
The coronavirus pandemic and aerosols: Does COVID-19 transmit via expiratory particles? | |
Epidemiological Characteristics of Imported Influenza A (H1N1) Cases during the 2009 Pandemic in Korea | OBJECTIVES: Quarantine measure for prevention of epidemic disease and further evaluations of their efficiency are possible only by elaborating analyses of imported cases. The purpose of this study was to analyze descriptive epidemiological characteristics of pandemic influenza A (H1N1) cases imported to Korea. METHODS:... |
New Design for Aerosol Protection During Endotracheal Intubation in the COVID-19 Pandemic Era: The "Anti-Aerosol Igloo" (AAI) | |
Simulation of the interferon-mediated protective field in lymphoid organs with their spatial and functional organization taken into consideration | |
COVID-19 pandemic: Emerging perspectives and future trends | World is living on the edge. The human cost of COVID pandemic could be extraordinary. We find ourselves in a time of great economic, social, and medical uncertainty. The pandemic demands action on many fronts, from prevention to testing to treatment. We need to create simple, cheap, more accessible testing for SARS-CoV... |
Inhibitors of signal peptide peptidase and subtilisin/kexin-isozyme 1 inhibit Ebola virus glycoprotein-driven cell entry by interfering with activity and cellular localization of endosomal cathepsins | Emerging viruses such as severe fever and thrombocytopenia syndrome virus (SFTSV) and Ebola virus (EBOV) are responsible for significant morbidity and mortality. Host cell proteases that process the glycoproteins of these viruses are potential targets for antiviral intervention. The aspartyl protease signal peptide pep... |
Chapter 13 Animals and Human Health Where Do They Meet? ∗ | Abstract Human health and animal health are closely intertwined. We share hundreds of diseases with animals, and they are vectors for many diseases that assail humans—but, at the same time, they are essential to many treatments and cures. We discuss in this chapter various aspects of intimate relationship between human... |
Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19 | The outbreak of COVID-19 caused by 2019–nCov/SARS-CoV-2 has become a pandemic with an urgent need for understanding the mechanisms and identifying a treatment. Viral infections including SARS-CoV are associated with increased levels of reactive oxygen species, disturbances of Ca(++) caused by unfolded protein response ... |
Neurological complications of pandemic influenza A H1N1 2009 infection: European case series and review | Neurological manifestations and outcomes of children with the 2009 H1N1 virus infection have been reported in three American series and from smaller cohorts and case reports worldwide. Of the 83 children admitted between April 2009 and March 2010 with H1N1 virus infection to a tertiary children’s hospital in a European... |
Attitudes of consumers and live-poultry workers to central slaughtering in controlling H7N9: a cross-sectional study | BACKGROUND: Guangdong Province in the Pearl River Delta of Southeast China is among the areas in the country with the highest rates of avian flu cases. In order to control the outbreak of human-infected H7N9 cases, Guangdong launched a new policy on the central slaughtering of live poultry in 2015. This study aims to e... |
A randomized multicenter clinical trial to evaluate the efficacy of melatonin in the prophylaxis of SARS-CoV-2 infection in high-risk contacts (MeCOVID Trial): A structured summary of a study protocol for a randomised controlled trial | OBJECTIVES: Primary objective: to evaluate the efficacy of melatonin as a prophylactic treatment on prevention of symptomatic SARS-CoV-2 infection among healthcare workers at high risk of SARS-CoV-2 exposure. To evaluate the efficacy of melatonin as a prophylactic treatment on prevention of asymptomatic SARS-CoV-2 infe... |
Estimation of basic reproduction number of the Middle East respiratory syndrome coronavirus (MERS-CoV) during the outbreak in South Korea, 2015 | BACKGROUND: In South Korea, an outbreak of Middle East respiratory syndrome (MERS) occurred in 2015. It was the second largest MERS outbreak. As a result of the outbreak in South Korea, 186 infections were reported, and 36 patients died. At least 16,693 people were isolated with suspicious symptoms. This paper estimate... |
COVID‐19 infection may cause ketosis and ketoacidosis | The present study included 658 hospitalized patients with confirmed COVID‐19. Forty‐two (6.4%) out of 658 patients presented with ketosis on admission with no obvious fever or diarrhoea. They had a median (interquartile range [IQR]) age of 47.0 (38.0–70.3) years, and 16 (38.1%) were men. Patients with ketosis were youn... |
Premorbid factors and outcome associated with respiratory virus infections in a pediatric intensive care unit | OBJECTIVES: The purpose of this study was to report the clinical features and outcome of all children with a laboratory proven diagnosis of respiratory virus infection admitted to a university Pediatric Intensive Care Unit (PICU). METHODS: Retrospective study between January 2003 and April 2007 was carried out in the P... |
Vaccine Development in the Twenty-First Century: Changing Paradigms for Elusive Viruses | |
Mechanism of baricitinib supports artificial intelligence‐predicted testing in COVID‐19 patients | Baricitinib, is an oral Janus kinase (JAK)1/JAK2 inhibitor approved for the treatment of rheumatoid arthritis (RA) that was independently predicted, using artificial intelligence (AI)‐algorithms, to be useful for COVID‐19 infection via a proposed anti‐cytokine effects and as an inhibitor of host cell viral propagation.... |
TYPE 1 DIABETES TRIGGERED BY COVID-19 PANDEMIC: A POTENTIAL OUTBREAK? | |
Molecular Genotyping of Microbes by Multilocus PCR and Mass Spectrometry: A New Tool for Hospital Infection Control and Public Health Surveillance | We describe a new technology for the molecular genotyping of microbes using a platform known commercially as the Ibis T5000. The technology couples multilocus polymerase chain reaction (PCR) to electrospray ionization/mass spectrometry (PCR/ESI-MS) and was developed to provide rapid, high-throughput, and precise digita... |
Coronavirus infection of the central nervous system: host–virus stand-off | Several viruses infect the mammalian central nervous system (CNS), some with devastating consequences, others resulting in chronic or persistent infections associated with little or no overt pathology. Coronavirus infection of the murine CNS illustrates the contributions of both the innate immune response and specific ... |
Epidemiologic Parameters of the Middle East Respiratory Syndrome Outbreak in Korea, 2015 | BACKGROUND: Epidemiologic parameters are important in planning infection control policies during the outbreak of emerging infections. Korea experienced an outbreak of Middle East Respiratory Syndrome coronavirus (MERS-CoV) infection in 2015, which was characterized by superspreading events in healthcare settings. We ai... |
Viral Infections and Associated Factors That Promote Acute Exacerbations of Asthma | Despite asthma being the most common chronic childhood ailment, there is still much to learn about the disease. Early childhood infections with well-known or emerging viruses can lay the pathophysiologic framework for asthma development and exacerbation later in life, which may be due partly to alteration of the airway... |
Restricted family visiting in intensive care during COVID19 | |
Banking for health: the role of financial sector actors in investing in global health | The world faces multiple health financing challenges as the global health burden evolves. Countries have set an ambitious health policy agenda for the next 15 years with prioritisation of universal health coverage under the Sustainable Development Goals. The scale of investment needed for equitable access to health ser... |
Aptamers in Diagnostics and Treatment of Viral Infections | Aptamers are in vitro selected DNA or RNA molecules that are capable of binding a wide range of nucleic and non-nucleic acid molecules with high affinity and specificity. They have been conducted through the process known as SELEX (Systematic Evolution of Ligands by Exponential Enrichment). It serves to reach specifici... |
Wellness in pediatric radiology: lessons learned in a time of pandemic | |
The Canadian Pandemic Influenza Plan: an evolution to the approach for national communicable disease emergencies | Abstract Advance planning for a large-scale and widespread health emergency is required to optimize health care delivery during an influenza pandemic. The Canadian Pandemic Influenza Plan (CPIP) is an example of a successful communicable disease emergency plan that ensures a national, coordinated approach to preparedne... |
After the COVID-19 pandemic: returning to normalcy or returning to a new normal? | Abstract The novel coronavirus, SARS-CoV-2, pandemic has delivered a profound and negative impact on the United States. The suspension of elective surgeries including arthroplasty will have a lasting effect on all stakeholders including patients, physicians, and healthcare organizations within the US healthcare system.... |
Enteric viruses in HIV-related diarrhoea | Abstract HIV-related diarrhoea is an important cause of morbidity and mortality in HIV infection. Cytomegalovirus is a well-established cause of diarrhoea, but the role of other enteric viruses is less clear and will be discussed here. The clinical manifestations, disease mechanisms, diagnostic techniques and current t... |
An emergency responding mechanism for cruise epidemic prevention—taking COVID-19 as an example | COVID-19 has severely impacted the global cruise tourism industry. The increasing number of confirmed cases during the quarantine period of ‘Diamond Princess’ questioned the efficiency and science behind the Japanese government's emergency management of the outbreak and led to a debate on the responsibilities of the sh... |
Some lessons from the COVID‐19 pandemic | |
Richard Allen Williams, M.D.: a Career Fighting Disparities and Fostering Equity | This is a literature review where we acknowledge Richard Allen Williams, the first African American physician to win the John P. McGovern Compleat Physician Award, and recognize his achievements in race and ethnicity in healthcare. There have been significant advances in the diagnosis and treatment of cardiovascular di... |
Chapter 9 Diverse Roles of DEAD/DEAH-Box Helicases in Innate Immunity and Diseases | Abstract DEAD/DEAH-box helicases are enzymes that belong to the DEAD/H-box family of SF2 helicase superfamily. These enzymes are essential in RNA metabolism, where they are involved in a number of processes that require manipulation of RNA structure. Recent studies have found that some DEAD/DEAH-box helicases play impo... |
Experience of establishing severe acute respiratory surveillance in the Netherlands: evaluation and challenges | Abstract The 2009 influenza A(H1N1) pandemic prompted the World Health Organization (WHO) to recommend countries to establish a national severe acute respiratory infections (SARI) surveillance system for preparedness and emergency response. However, setting up or maintaining a robust SARI surveillance system has been c... |
Emerging viral diseases in kidney transplant recipients | Viruses are the most important cause of infections and a major source of mortality in Kidney Transplant Recipients (KTRs). These patients may acquire viral infections through exogenous routes including community exposure, donor organs, and blood products or by endogenous reactivation of latent viruses. Beside major opp... |
Chapter 19 Advantages and Limitations of Commonly Used Nonhuman Primate Species in Research and Development of Biopharmaceuticals | Abstract Nonhuman primates (NHPs) have been used extensively during the past four decades for research and nonclinical development because they are close to humans in terms of genetics, anatomy, physiology, and immunology. They have been widely used in the development of infection models, leading to the generation of v... |
Human immunodeficiency virus infection (HIV)–associated rheumatic manifestations in thepre- and post-HAART eras | Rheumatic manifestations remain an important clinical manifestation associated to HIV. To date after 4 decades of the onset of the HIV/AIDS pandemic, almost 37 million individuals are living with the infection, including close to 2 million of newly infected individuals. The status, however, of a considerable proportion... |
The effect of respiratory viral assay panel on antibiotic prescription patterns at discharge in adults admitted with mild to moderate acute exacerbation of COPD: a retrospective before- after study | BACKGROUND: Despite well-defined criteria for use of antibiotics in patients presenting with mild to moderate Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD), their overuse is widespread. We hypothesized that following implementation of a molecular multiplex respiratory viral panel (RVP), AECOPD pa... |
Linking Human Destruction of Nature to COVID-19 Increases Support for Wildlife Conservation Policies | This paper investigates if narratives varying the cause of the COVID-19 pandemic affects pro-wildlife conservation outcomes. In a pre-registered online experiment (N = 1081), we randomly allocated subjects to either a control group or to one of three narrative treatment groups, each presenting a different likely cause ... |
Expression of Single Chain Variable Fragment (scFv) Molecules in Plants: A Comprehensive Update | Single chain variable fragments (scFvs) are generated by joining together the variable heavy and light chain of a monoclonal antibody (mAb) via a peptide linker. They offer some advantages over the parental mAb such as low molecular weight, heterologous production, multimeric form, and multivalency. The scFvs were prod... |
Integrating the preventive medicine specialty in the rural and public health workforce | Abstract The majority of the U.S. American Indian and Alaska Native (AI/AN) population live in rural areas, and are thus disproportionately affected by rural health issues. In addition, the AI/AN population has unique health characteristics resulting from a distinct cultural and sociopolitical history. A public health ... |
Mouse hepatitis virus nasoencephalopathy is dependent upon virus strain and host genotype | Mouse hepatitis virus (MHV) S induced typical MHV spongiform lesions in brainstem 28 days following intranasal inoculation of adult A/J, BALB/cByJ, CBA/J, C3H/HeJ and C3H/RV, but not SJL mice. In all but SJL mice, brain lesions occurred at or near the infectious dose level, based on seroconversion by the indirect immun... |
Análisis de las tasas de letalidad de la infección por SARS-CoV-2 en las Comunidades Autónomas de España | Resumen Introducción: La pandemia por el virus SARS-CoV-2 ha supuesto un auténtico reto para los sistemas sanitarios. En España, la distribución heterogénea del virus y las diferentes estrategias sanitarias han condicionado la morbilidad y letalidad. El objetivo de este estudio fue analizar la letalidad de la infección... |
Travel-related MERS-CoV cases: an assessment of exposures and risk factors in a group of Dutch travellers returning from the Kingdom of Saudi Arabia, May 2014 | BACKGROUND: In May 2014, Middle East respiratory syndrome coronavirus (MERS-CoV) infection, with closely related viral genomes, was diagnosed in two Dutch residents, returning from a pilgrimage to Medina and Mecca, Kingdom of Saudi Arabia (KSA). These patients travelled with a group of 29 other Dutch travellers. We con... |
Slum Livestock Agriculture | Abstract Slums are unplanned squatter human settlements in peri-urban and urban areas where more than 800 million people live. These densely populated areas lack basic public services. Livestock raised in these conditions compete with humans for space and water, and pose a risk to human and animal health. Notwithstandi... |
Comment on “The neuroinvasive potential of SARS‐CoV‐2 may play a role in the respiratory failure of COVID‐19 patients” | We have read with great care and interest the article by Li et al The authors provide interesting elements with respect to the possible entry of severe acute respiratory syndrome coronavirus 2 at the brain area and plead for an implication of the central nervous system in respiratory problems linked to coronavirus dise... |
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