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Modelling SARS-COV2 Spread in London: Approaches to Lift the Lockdown | Abstract Objective To use mathematical models to predict the epidemiological impact of lifting the lockdown in London, UK, and alternative strategies to help inform policy in the UK. Methods A mathematical model for the transmission of SARS-CoV2 in London. The model was parametrised using data on notified cases, deaths... |
Chapter 496 Arterivirus Papain-like Proteinase 1β | The third edition of the Handbook of Proteolytic Enzymes aims to be a comprehensive reference work for the enzymes that cleave proteins and peptides, and contains over 800 chapters. Each chapter is organized into sections describing the name and history, activity and specificity, structural chemistry, preparation, biol... |
Dual Analysis of the Murine Cytomegalovirus and Host Cell Transcriptomes Reveal New Aspects of the Virus-Host Cell Interface | Major gaps in our knowledge of pathogen genes and how these gene products interact with host gene products to cause disease represent a major obstacle to progress in vaccine and antiviral drug development for the herpesviruses. To begin to bridge these gaps, we conducted a dual analysis of Murine Cytomegalovirus (MCMV)... |
Talk COVID to Me: Language Rights and Canadian Government Responses to the Pandemic | Since the COVID-19 outbreak, a gradual loosening of linguistic obligations in public institutions and governments has been observed in various jurisdictions in Canada. This article argues that in addition to legal requirements to provide minority language services, it is not justifiable for governments to suspend or cu... |
Using machine learning to predict ICU transfer in hospitalized COVID-19 patients | Objectives: Approximately 20–30% of patients with COVID-19 require hospitalization, and 5–12% may require critical care in an intensive care unit (ICU). A rapid surge in cases of severe COVID-19 will lead to a corresponding surge in demand for ICU care. Because of constraints on resources, frontline healthcare workers ... |
Molecular Targets in the Chemotherapy of Coronavirus Infection | In the pathogenesis of the infectious process in the respiratory tract by SARS, MERS, and COVID-19 coronaviruses, two stages can be distinguished: early (etiotropic) and late (pathogenetic) ones. In the first stage, when the virus multiplication and accumulation are prevalent under insufficient host immune response, th... |
Transmission and Effect of Multiple Clusters of Seasonal Influenza in a Swiss Geriatric Hospital | OBJECTIVES: To investigate a nosocomial outbreak of influenza. DESIGN: Prospective outbreak investigation with active case finding and molecular typing. SETTING: A large academic geriatric hospital in Switzerland. PARTICIPANTS: Elderly hospitalized adults. MEASUREMENTS: Based on syndromic surveillance, a nosocomial inf... |
High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study | PURPOSE: Little evidence of increased thrombotic risk is available in COVID-19 patients. Our purpose was to assess thrombotic risk in severe forms of SARS-CoV-2 infection. METHODS: All patients referred to 4 intensive care units (ICUs) from two centers of a French tertiary hospital for acute respiratory distress syndro... |
Epidemieën zijn moeilijk beheersbaar | Halverwege de vorige eeuw had men een groot vertrouwen in de beheersbaarheid van infectieziekten. Maar nu, veertig jaar later, is het optimisme omgeslagen in bezorgdheid voor de toekomst. Hoe terecht is dat? In dit inleidend hoofdstuk wordt kort ingegaan op begrippen als ‘uitbraak’ en zoönose, de historie van pestilent... |
Risk, resilience, psychological distress, and anxiety at the beginning of the COVID‐19 pandemic in Germany | BACKGROUND: The current COVID‐19 pandemic comes with multiple psychological stressors due to health‐related, social, economic, and individual consequences and may cause psychological distress. The aim of this study was to screen the population in Germany for negative impact on mental health in the current COVID‐19 pand... |
Electron microscopy of stool‐shed viruses: Retention of characteristic morphologies after long‐term storage at ultralow temperatures | Storage of stool specimens at —70°C has been reported to destroy the characteristic morphology of calicivirus. To determine if other stool‐shed viruses are similarly affected, stool specimens previously examined by electron microscopy and observed to contain virus particles were reexamined after 6–10 years of storage a... |
Exposure to greenspaces could reduce the high global burden of pain | Abstract Painful conditions are among the leading causes of years lived with disability. To reduce this burden, novel, cost-effective and accessible interventions are required. We propose that greenspace exposure may be one such intervention. Drawing on evidence from neuroscience, physiology, microbiology, and psycholo... |
Safety and efficacy assessment of allogeneic human dental pulp stem cells to treat patients with severe COVID-19: structured summary of a study protocol for a randomized controlled trial (Phase I / II) | OBJECTIVES: To assess the safety and therapeutic effects of allogeneic human dental pulp stem cells (DPSCs) in treating severe pneumonia caused by COVID-19. TRIAL DESIGN: This is a single centre, two arm ratio 1:1, triple blinded, randomized, placebo-controlled, parallel group, clinical trial. PARTICIPANTS: 1. Adults a... |
Mayo Clinic Strategies for COVID-19 Avoiding a Medical Education Quarantine During the Pandemic | |
Adverse drug reactions and interactions: first reports and special situations | |
Chapter 34 Mannose–fucose recognition by DC-SIGN | Publisher Summary Dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN). DC-SIGN is a C-type lectin receptor that recognizes N-linked high-mannose oligosaccharides and branched fucosylated structures. It is now clear that the biological role of DC-SIGN is two-fold. It is primarily expressed by dendritic cells a... |
Coronavirus (COVID‐19): Patient experience—Administrative services on the frontline during crisis | The COVID‐19 pandemic has had a dramatic impact on care delivery among health care institutions and providers in the United States. As a categorical cancer center, MD Anderson has prioritized care for our patients based on acuity of their disease. We continue to implement measures to protect patients and employees from... |
Correction: Middle East Respiratory Syndrome Coronavirus Intra-Host Populations Are Characterized by Numerous High Frequency Variants | [This corrects the article DOI: 10.1371/journal.pone.0146251.]. |
Unveiling cultures in emergency response communication networks on social media: following the 2016 Louisiana floods | While culture in emergency management has gained attention from the field of risk communication, few have systemically dealt with the nuances of general culture involved in the formation and differentiation of risk communication. To fill this gap, this research aims to first examine cultural nuances from the 2016 Louis... |
Clinical Characteristics and Results of Semen Tests Among Men With Coronavirus Disease 2019 | This cohort study examines the clinical characteristics of men with coronavirus disease 2019 whose semen tested positive for severe acute respiratory syndrome coronavirus 2. |
Estimation of the number of blood donors during the COVID‐19 incubation period across China and analysis of prevention and control measures for blood transfusion transmission | BACKGROUND: The aim of this study was to estimate the number of blood donors during the COVID‐19 incubation period across China. STUDY DESIGN AND METHODS: In this study, we developed a predictive model to estimate the number of blood donors during the COVID‐19 incubation period among 34 provincial regions in China. Our... |
Similarities between the Yin/Yang Doctrine and Hormesis in Toxicology and Pharmacology | Hormesis is a generalizable dose–response relationship characterized by low-dose stimulation and high-dose inhibition. Despite debate over this biphasic dose–response curve, hormesis is challenging central beliefs in the evaluation of chemicals or drugs and has influenced biological model selection, concentration range... |
International surgical guidance for COVID-19: Validation using an international Delphi process - Cross-sectional study | BACKGROUND: International professional bodies have been quick to disseminate initial guidance documents during the COVID-19 pandemic. In the absence of firm evidence, these have been developed by expert committees, limited in participant number. This study aimed to validate international COVID-19 surgical guidance usin... |
Health Communication during SARS | During the severe acute respiratory syndrome (SARS) outbreak, electronic media made it possible to disseminate prevention messages rapidly. The Centers for Disease Control and Prevention’s Travelers’ Health Web site was frequently visited in the first half of 2003; more than 2.6 million visits were made to travel alert... |
Rapid quantitative detection of Yersinia pestis by lateral-flow immunoassay and up-converting phosphor technology-based biosensor | Abstract Up-converting phosphor technology (UPT)-based lateral-flow immunoassay has been developed for quantitative detection of Yersinia pestis rapidly and specifically. In this assay, 400nm up-converting phosphor particles were used as the reporter. A sandwich immumoassay was employed by using a polyclonal antibody a... |
10.17 Metabolism of Glutathione S-Conjugates: Multiple Pathways | This is an update of Cooper, A.J.L., Hanigan, M.H., Enzymes Involved in Processing Glutathione Conjugates, Comprehensive Toxicology, Second Edition, edited by Charlene A. McQueen, Elsevier, Oxford, 2010, Volume 4, Pages 323–366. |
Contribution of Host Intracellular Transport Machineries to Intercellular Movement of Turnip Mosaic Virus | The contribution of different host cell transport systems in the intercellular movement of turnip mosaic virus (TuMV) was investigated. To discriminate between primary infections and secondary infections associated with the virus intercellular movement, a gene cassette expressing GFP-HDEL was inserted adjacent to a TuM... |
Viral Loads in Clinical Specimens and SARS Manifestations | A retrospective viral load study was performed on clinical specimens from 154 patients with laboratory-confirmed severe acute respiratory syndrome (SARS); the specimens were prospectively collected during patients' illness. Viral load in nasopharyngeal aspirates (n = 142) from day 10 to day 15 after onset of symptoms w... |
Prisons confinées: quelles conséquences pour les soins psychiatriques et la santé mentale des personnes détenues en France? | Résumé Objectif. En France, les mesures de confinement ont été accompagnées de dispositions spécifiques pour les prisons: suspension des activités, parloirs et interventions extérieures. Plus de dix mille personnes détenues ont en outre été libérées pour diminuer le taux d’occupation des établissements et limiter la pr... |
Dietary Probiotic Compound Improves Reproductive Performance of Porcine Epidemic Diarrhea Virus-Infected Sows Reared in a Japanese Commercial Swine Farm under Vaccine Control Condition | Lactogenic immunity transferred to piglets after inoculation of a live vaccine to pregnant sows was proved limited to control porcine epidemic diarrhea (PED). Hence, here we evaluated the efficacy of administration of a probiotic compound containing Bacillus mesentericus, Clostridium butyricum, and Enterococcus faecali... |
COVID‐19 convalescent plasma: phase 2 | |
SINS model in the management of biosafety level 2 laboratories: exploration and practice | Abstract A significant number of biosafety level 2 (BSL-2) laboratories have been established in many countries for studies of various types of pathogenic agents and other infectious biological materials. The harmonized management of biological risks in such diverse laboratories thus appears as a real challenge. Zhejia... |
Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019‐nCoV | With the current trajectory of the 2019‐nCoV outbreak unknown, public health and medicinal measures will both be needed to contain spreading of the virus and to optimize patient outcomes. Although little is known about the virus, an examination of the genome sequence shows strong homology with its better‐studied cousin... |
Genomic Sequencing of the Severe Acute Respiratory Syndrome-Coronavirus | The polymerase chain reaction (PCR), which can exponentially replicate a target DNA sequence, has formed the basis for the sensitive and direct examination of clinical samples for evidence of infection. During the epidemic of severe acute respiratory syndrome (SARS) in 2003, PCR not only offered a rapid way to diagnose... |
COVID-19 and opportunities for international cooperation in health. | |
A long-term animal experiment indicating persistent infection of bovine coronavirus in cattle | A long-term animal experiment involving inoculation with bovine coronavirus (BCoV) was conducted to verify its persistent infection in cattle. Three colostrum-deprived Holstein calves were housed separately in individual rooms of a high-containment facility and inoculated with the BCoV strain Kumamoto/1/07. Until the e... |
Update in the treatment of non-influenza respiratory virus infection in solid organ transplant recipients | Introduction: Despite the improved outcomes in solid organ transplantation with regard to prevention of rejection and increased patient and graft survival, infection remains a common cause of morbidity and mortality. Respiratory viruses are a frequent and potentially serious cause of infection after solid organ transpl... |
An In-Silico Investigation of Phytochemicals as Antiviral Agents Against Dengue Fever | Abstract: A virtual screening analysis of our library of phytochemical structures with dengue virus protein targets has been carried out using a molecular docking approach. A total of 2194 plant-derived secondary metabolites have been docked. This molecule set comprised of 290 alkaloids (68 indole alkaloids, 153 isoqui... |
COVID-19 Pandemic: Knowledge and Perceptions of the Public and Healthcare Professionals | Background and objective The recent pandemic due to the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a major concern for the people and governments across the world due to its impact on individuals as well as on public health. The infectiousness and the quick spread across the world mak... |
Severe Acute Respiratory Illness Deaths in Sub-Saharan Africa and the Role of Influenza: A Case Series From 8 Countries | Background. Data on causes of death due to respiratory illness in Africa are limited. Methods. From January to April 2013, 28 African countries were invited to participate in a review of severe acute respiratory illness (SARI)–associated deaths identified from influenza surveillance during 2009–2012. Results. Twenty-th... |
Policy and Pandemic: The Changing Practice of Nephrology During the COVID-19 Outbreak | ABSTRACT The coronavirus (COVID-19) pandemic has changed care delivery for patients with end-stage kidney disease (ESKD). We explore the United States healthcare system as it pertains to dialysis care, including existing policies, modifications implemented in response to the COVID-19 crisis, and possible next steps for... |
Rotavirus prevalence and relationships with climatological factors in gabon, africa | A one‐year study of rotavirus prevalence was carried out using electron microscopy in Gabon, equatorial Africa. One hundred fifty‐six nonhospitalized diarrheic children up to 10 years of age and 115 age‐matched controls were investigated together with diarrheic adults and children over 10 years of age. Rotaviruses were... |
Non Structural Proteins 8 and 9 of Human Coronavirus 229E | |
Will the COVID-19 pandemic accelerate the implementation of single-day coronary angioplasty in Poland? | |
Offering patients more: how the West Africa Ebola outbreak can shape innovation in therapeutic research for emerging and epidemic infections | Although, after an epidemic of over 28 000 cases, there are still no licensed treatments for Ebola virus disease (EVD), significant progress was made during the West Africa outbreak. The pace of pre-clinical development was exceptional and a number of therapeutic clinical trials were conducted in the face of considerab... |
Improving immunological insights into the ferret model of human viral infectious disease | Ferrets are a well‐established model for studying both the pathogenesis and transmission of human respiratory viruses and evaluation of antiviral vaccines. Advanced immunological studies would add substantial value to the ferret models of disease but are hindered by the low number of ferret‐reactive reagents available ... |
Landscape of emerging and re-emerging infectious diseases in China: impact of ecology, climate, and behavior | For the past several decades, the infectious disease profile in China has been shifting with rapid developments in social and economic aspects, environment, quality of food, water, housing, and public health infrastructure. Notably, 5 notifiable infectious diseases have been almost eradicated, and the incidence of 18 a... |
The type I interferon response during viral infections: a “SWOT” analysis | The type I interferon (IFN) response is a strong and crucial moderator for the control of viral infections. The strength of this system is illustrated by the fact that, despite some temporary discomfort like a common cold or diarrhea, most viral infections will not cause major harm to the healthy immunocompetent host. ... |
Chapter 10 Organization of Public Health Systems | Abstract Public health consists of a complex of activities of public and private organizations working to protect and promote the health of the population, within laws, regulations, legal precedents, and ethics to ensure individual rights as well as those of society. Elected governments in unitary or federal states hav... |
International Air Travel to Ohio, USA, and the Impact on Malaria, Influenza, and Hepatitis A | The State of Ohio led the United States in measles in 2014, ostensibly related to international air travel (IAT), and ranked lower than 43 other states in infectious disease outbreak preparedness. We conducted a retrospective cohort study using surveillance data of the total Ohio population of 11 million from 2010 thro... |
Risk factors for adverse clinical outcomes with COVID-19 in China: a multicenter, retrospective, observational study | Background: The risk factors for adverse events of Coronavirus Disease-19 (COVID-19) have not been well described. We aimed to explore the predictive value of clinical, laboratory and CT imaging characteristics on admission for short-term outcomes of COVID-19 patients. Methods: This multicenter, retrospective, observat... |
Effect of Puumala hantavirus infection on human umbilical vein endothelial cell hemostatic function: platelet interactions, increased tissue factor expression and fibrinolysis regulator release | Puumala virus (PUUV) infection causes over 5000 cases of hemorrhagic fever in Europe annually and can influence the hemostatic balance extensively. Infection might lead to hemorrhage, while a recent study showed an increased risk of myocardial infarction during or shortly after PUUV infection. The mechanism by which th... |
Regulation of cellular innate antiviral signaling by ubiquitin modification | Host pattern-recognition receptors (PRRs) recognize pathogen-associated molecular patterns generated by invading viruses and initiate a series of signaling cascades that lead to the activation of interferon-regulatory factor 3 (IRF3) and nuclear factor-κB (NF-κB) and subsequent induction of type I interferons (IFNs). P... |
Biological response of using municipal solid waste compost in agriculture as fertilizer supplement | Waste management and declining soil fertility are the two main issues experienced by all developing nations, like India. Nowadays, agricultural utilization of Municipal Solid Waste (MSW) is one of the most promising and cost effective options for managing solid waste. It is helpful in solving two current burning issues... |
Acute Profound Sensorineural Hearing Loss after COVID-19 Pneumonia | |
Animal assisted intervention: A systematic review of benefits and risks | Abstract Introduction The therapeutic use of animals has been debated for decades, and its use explored in a variety of settings and populations. However, there is no uniformity on naming these interventions. Evidence based knowledge is essential to implement effective strategies in hospital. This review focused on the... |
Jede zweite akute Exazerbation viral bedingt?: Chronisch obstruktive Lungenerkrankung | |
Chapter 12 Early Warning Practice Using Internet-Based Data | Abstract On the Internet, there is a lot of open access information related to infectious diseases, e.g., official announcement, media news, bulletin boards, blogs, and other social media. If proper data retrieval and screening methods were applied on these Internet-based data, it would be very useful to improve the ti... |
Evolution of emergency medical calls during a pandemic – An emergency medical service during the COVID-19 outbreak | INTRODUCTION: Emergency Medical Services (EMS) are expected to be affected by a pandemic outbreak. However, the available data about trends and extents of these effects is limited. METHODS: We analyzed numbers of ambulance calls for all 136 diagnosis codes used by Magen David Adom (MDA), Israel's national EMS during 12... |
Experimental Dual Infection of Specific Pathogen‐Free Pigs with Porcine Reproductive and Respiratory Syndrome Virus and Pseudorabies Virus | Twenty 6‐week‐old specific pathogen‐free pigs were divided into four groups. On day 0 of the experiment, PRRSV–PRV (n = 6) and PRRSV (n = 4) groups were intranasally inoculated with porcine reproductive and respiratory syndrome virus (PRRSV) (10(5.6) TCID(50)). On day 7, the PRRSV–PRV and PRV (n = 6) groups were intran... |
Deletions into an NH2-terminal hydrophobic domain result in secretion of rotavirus VP7, a resident endoplasmic reticulum membrane glycoprotein | Rotavirus, a non-enveloped reovirus, buds into the rough endoplasmic reticulum and transiently acquires a membrane. The structural glycoprotein, VP7, a 38-kD integral membrane protein of the endoplasmic reticulum (ER), presumably transfers to virus in this process. The gene for VP7 potentially encodes a protein of 326 ... |
Respiratory illnesses in Canadian health care workers: a pilot study of influenza vaccine and oseltamivir prophylaxis during the 2007/2008 influenza season | Please cite this paper as: Coleman et al. (2011) Respiratory illnesses in Canadian health care workers: a pilot study of influenza vaccine and oseltamivir prophylaxis during the 2007/2008 influenza season. Influenza and Other Respiratory Viruses 5(6), 404–408. Background Data regarding both rates of acute respiratory i... |
High detection rates of nucleic acids of a wide range of respiratory viruses in the nasopharynx and the middle ear of children with a history of recurrent acute otitis media | Both bacteria and viruses play a role in the development of acute otitis media, however, the importance of specific viruses is unclear. In this study molecular methods were used to determine the presence of nucleic acids of human rhinoviruses (HRV; types A, B, and C), respiratory syncytial viruses (RSV; types A and B),... |
Artificial Intelligence in Diagnosis and Management of COVID‐19 in Dermatology | |
Localization of TGN38 to the trans-Golgi network: involvement of a cytoplasmic tyrosine-containing sequence | Protein localization to the TGN was investigated by examining the subcellular distribution of chimeric proteins in which the cytoplasmic and/or transmembrane domains of the TGN protein, TGN38, were substituted for the analogous domains of the plasma membrane protein, Tac. Using immunofluorescence and immunoelectron mic... |
Managing ACS during COVID-19 infection: do not follow the traditional route | COVID-19 pandemic is creating havoc in the world. It is also spreading in India creating a massive healthcare problem. Few major hospitals were closed down because of the spread among healthcare personnel. Management of several commonly occurring diseases needed modifications to a lesser or greater extent because of th... |
Isolation and Selection of Duck Primary Cells as Pathogenic and Innate Immunologic Cell Models for Duck Plague Virus | Duck plague virus (DPV) is a representative pathogen transmitted among aquatic animals that causes gross lesions and immune inhibition in geese and ducks. The mechanism of organ tropism and innate immune evasion of DPV has not been completely deciphered due to a lack of cell models to study the innate immune manipulati... |
Operating room team safety and perioperative anesthetic management of patients with suspected or confirmed novel corona virus in resource limited settings: A systematic review | Abstract Background Novel Corona Virus is a pandemic infectious disease which affects all age groups with higher incidence in geriatric population and chronic diseases. Contact, droplet and airborne had a role for transmission of the disease during airway manoeuvres in infected patients. This study aimed to prepare the... |
Employment‐Based, For‐Profit Health Care in a Pandemic | The emergence of Covid‐19 in the United States has revealed a critical weakness in the health care system in the United States. The majority of people in the nation receive health care via employment‐based health insurance from providers in a competitive market. However, neither employment‐based health care nor a compe... |
Prediction of class I T-cell epitopes: evidence of presence of immunological hot spots inside antigens | Motivation: Processing and presentation of major histocompatibility complex class I antigens to cytotoxic T-lymphocytes is crucial for immune surveillance against intracellular bacteria, parasites, viruses and tumors. Identification of antigenic regions on pathogen proteins will play a pivotal role in designer vaccine ... |
Molecular mimicry and immune‐mediated diseases | Molecular mimicry has been proposed as a pathogenetic mechanism for autoimmune disease, as well as a probe useful in uncovering its etiologic agents. The hypothesis is based in part on the abundant epidemiological, clinical, and experimental evidence of an association of infectious agents with autoimmune disease and ob... |
Experience of Chicagoland acute care hospitals in preparing for Ebola virus disease, 2014–2015 | During the 2014–2015 Ebola Virus Disease (EVD) outbreak, hospitals in the United States selected personal protective equipment (PPE) and trained healthcare personnel (HCP) in anticipation of receiving EVD patients. To improve future preparations for high-consequence infectious diseases, it was important to understand f... |
A Field-Proven Yeast Two-Hybrid Protocol Used to Identify Coronavirus–Host Protein–Protein Interactions | Over the last 2 decades, yeast two-hybrid became an invaluable technique to decipher protein–protein interaction networks. In the field of virology, it has proven instrumental to identify virus–host interactions that are involved in viral embezzlement of cellular functions and inhibition of immune mechanisms. Here, we ... |
Rapid responses in the emergency department of Linkou Chang Gung Memorial Hospital, Taiwan effectively prevents spread of COVID-19 among healthcare workers of emergency department during outbreak: Lessons learnt from SARS | Linkou Chang Gung Memorial Hospital, Taiwan has been on the forefront of efforts to manage and mitigate the Coronavirus Disease 2019 (COVID-19) pandemic since 20th January 2020. Despite having one of the largest and busiest emergency departments (EDs) in the world, we have managed to maintain a “zero-infection” rate am... |
Viral respiratory infections in hospitalized and community control children in Alaska, | Respiratory syncytial virus (RSV) in Alaska Native children from the Yukon Kuskokwim (YK) Delta is associated with a hospitalization rate five times higher than that reported for the general US child population. The role of other viral respiratory pathogens has not been studied in this population. YK Delta children <3 ... |
Mit Immanuel Kant in die zweite Welle der gegenwärtigen Pandemie | BACKGROUND: The efficacy of the most serious limitation of free movement of the German citizens since the end of the World War II and the Oil Crisis 1973 as intended countermeasure against the first wave of the pandemic is currently expected. The planning in regard to further action for the coming weeks and months has ... |
Metagenomic Nanopore sequencing of influenza virus direct from clinical respiratory samples | Influenza is a major global public health threat as a result of its highly pathogenic variants, large zoonotic reservoir, and pandemic potential. Metagenomic viral sequencing offers the potential of a diagnostic test for influenza which also provides insights on transmission, evolution and drug resistance, and simultan... |
Situación de la infección por SARS-CoV-2 en pacientes en tratamiento renal sustitutivo Informe del Registro COVID-19 de la Sociedad Española de Nefrología (S.E.N.) | RESUMEN La reciente aparición de la pandemia por el coronavirus SARS-CoV-2 ha impactado de forma muy importante en la población general. Los pacientes en tratamiento renal sustitutivo (TRS) no han sido ajenos a esta situación y por sus características resultan especialmente vulnerables. Presentamos los resultados del a... |
Heart failure exacerbation as only presenting sign of COVID-19 | With the increasing number of confirmed cases and accumulating clinical data, our understanding of COVID-19 continues to evolve. Here we describe the case of a patient who was initially admitted for decompensated heart failure with reduced ejection fraction (HFrEF). Only later in his course did he develop fever that le... |
Management strategies in the treatment of neonatal and pediatric gastroenteritis | Acute gastroenteritis, characterized by the onset of diarrhea with or without vomiting, continues to be a major cause of morbidity and mortality in children in mostly resource-constrained nations. Although generally a mild and self-limiting disease, gastroenteritis is one of the most common causes of hospitalization an... |
Characterize health and economic vulnerabilities of workers to control the emergence of COVID-19 in an industrial zone in Vietnam | The detection of first COVID-19 infected industrial worker in Vietnam on 13 April 2020 prompted timely effort to examine the health problems, behaviors, and health services access of industrial workers to inform effective and appropriate COVID-19 control measures, minimizing the risk of industrial sites becoming the ne... |
Emerging Infectious Diseases: a Review | PURPOSE OF REVIEW: This review highlights some of the recent concerning emerging infectious diseases, a number of them specifically that the World Health Organization has categorized as priorities for research. RECENT FINDINGS: Emerging and reemerging infectious diseases account for significant losses in not only human... |
Human (non‐severe acute respiratory syndrome) coronavirus infections in hospitalised children in France | Aim: This study has two objectives: to study the clinical symptoms associated with the detection of the four human coronaviruses (HCoVs), 229E, OC43, NL63 and HKU1 types, in the respiratory specimens sampled from hospitalised children in France between September 2004 and May 2005; and to develop a multiplex reverse tra... |
Acute Epstein-Barr related myocarditis: An unusual but life-threatening disease in an immunocompetent patient | Abstract Myocarditis is an uncommon but potentially life-threatening disease. Clinical manifestations could range from subclinical disease to sudden death, due to fulminant heart failure and/or malignant ventricular arrhythmias. The most common cause of myocarditis is viral infection, including Epstein-Barr virus (EBV)... |
Full-length Ebola glycoprotein accumulates in the endoplasmic reticulum | The Filoviridae family comprises of Ebola and Marburg viruses, which are known to cause lethal hemorrhagic fever. However, there is no effective anti-viral therapy or licensed vaccines currently available for these human pathogens. The envelope glycoprotein (GP) of Ebola virus, which mediates entry into target cells, i... |
Transcriptional changes detected in fecal RNA of neonatal dairy calves undergoing a mild diarrhea are associated with inflammatory biomarkers | After birth, a newborn calf has to adapt to an extrauterine life characterized by several physiological changes. In particular, maturation of the gastrointestinal tract in a new environment loaded with potential pathogens, which can predispose neonatal calves to develop diarrhea, and is a major cause of morbidity and m... |
Host response-based screening to identify undiagnosed cases of COVID-19and expand testing capacity | The COVID-19 pandemic has created unprecedented challenges in diagnostic testing. At the beginning of the epidemic, a confluence of factors resulted in delayed deployment of PCR-based diagnostic tests, resulting in lack of testing of individuals with symptoms of the disease. Although these tests are now more widely ava... |
An Old Solution for a New Problem: Antiserum against Emerging Infectious Diseases | |
Filtration Efficiencies of Nanoscale Aerosol by Cloth Mask Materials Used to Slow the Spread of SARS-CoV-2 | [Image: see text] Filtration efficiency (FE), differential pressure (ΔP), quality factor (QF), and construction parameters were measured for 32 cloth materials (14 cotton, 1 wool, 9 synthetic, 4 synthetic blends, and 4 synthetic/cotton blends) used in cloth masks intended for protection from the SARS-CoV-2 virus (diame... |
The effect of build orientation on both flexural quasi-static and fatigue behaviours of filament deposited PA6 polymer | The present paper aims to study the effect of manufacturing build orientation on both flexural quasi-static and fatigue behaviours of semi-crystalline polyamide 6 obtained by Fused Filament Fabrication (FFF), by considering the porosity and surface roughness. The glass transition temperature, melting temperature, and c... |
Development of the full-length cDNA clones of two porcine epidemic diarrhea disease virus isolates with different virulence | The recently emerged highly virulent variants of porcine epidemic and diarrhea virus (PEDV) remain a huge threat to the worldwide swine industry. Here, we describe the development of a bacterial artificial chromosome (BAC) reverse genetics system for PEDV based on two recent Chinese field isolates, namely CHM2013 and B... |
Complement Receptor 1: Disease associations and therapeutic implications | Abstract Exaggerated complement activation is a key event in the pathogenesis of a range of autoimmune and inflammatory diseases. Complement Receptor 1 (CR1) has emerged as a molecule of immense interest in gaining insight to the susceptibility, pathophysiology, diagnosis, prognosis and therapy of such diseases. This r... |
Antibody Tests in Detecting SARS-CoV-2 Infection: A Meta-Analysis | The emergence of Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 made imperative the need for diagnostic tests that can identify the infection. Although Nucleic Acid Test (NAT) is considered to be the gold standard, serological tests based on antibodies could be very helpful. However, individual studies are us... |
Influenza A (H1N1) pneumonia: HRCT findings | OBJECTIVE: To describe aspects found on HRCT scans of the chest in patients infected with the influenza A (H1N1) virus. METHODS: We retrospectively analyzed the HRCT scans of 71 patients (38 females and 33 males) with H1N1 infection, confirmed through laboratory tests, between July and September of 2009. The HRCT scans... |
Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins | Viral diseases remain serious threats to public health because of the shortage of effective means of control. To combat the surge of viral diseases, new treatments are urgently needed. Here we show that small-molecules, which inhibit cellular anti-apoptotic Bcl-2 proteins (Bcl-2i), induced the premature death of cells ... |
Response to Char's comment: Comment on Li et al.: COVID‐19 patients' clinical characteristics, discharge rate, and fatality rate of meta‐analysis | We have read Char's comment(1). Thanks for readers’ attention and valuable feedback on our article. Following was our response to Char's question about data overlap. Firstly, the meta‐analysis reprocessed the existing data about COVID‐19 patients in published articles, and involved no other information outside of the a... |
Identification of a Novel Polyomavirus from Patients with Acute Respiratory Tract Infections | We report the identification of a novel polyomavirus present in respiratory secretions from human patients with symptoms of acute respiratory tract infection. The virus was initially detected in a nasopharyngeal aspirate from a 3-year-old child from Australia diagnosed with pneumonia. A random library was generated fro... |
Public Awareness of Nature and the Environment During the COVID-19 Crisis | As our behavioral patterns change due to the COVID-19 crisis, our impact on nature and the environment changes too. Pollution levels are showing significant reductions. People are more aware of the importance of access to local green and blue spaces. By analyzing online search behavior in twenty European countries, we ... |
MERS transmission and risk factors: a systematic review | BACKGROUND: Since Middle East respiratory syndrome (MERS) infection was first reported in 2012, many studies have analysed its transmissibility and severity. However, the methodology and results of these studies have varied, and there has been no systematic review of MERS. This study reviews the characteristics and ass... |
A Syndemic of COVID-19 and methanol poisoning in Iran: Time for Iran to consider alcohol use as a public health challenge? | • While all activities surrounding alcohol is banned in Iran, mass methanol poisoning outbreaks (such as the one amid the COVID-19 epidemic with more than 5,000 poisonings and more than 700 deaths within only two months) have become a major public health concern. • Iran’s national policymakers should consider developin... |
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