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COVID-19 Infection Fatality Rate Associated with Incidence—A Population-Level Analysis of 19 Spanish Autonomous Communities | Previous studies have found large variations in the COVID-19 infection fatality rate (IFR). This study hypothesized that IFR would be influenced by COVID-19 epidemic intensity. We tested the association between epidemic intensity and IFR using serological results from a recent large SARS-CoV-2 serosurvey (N = 60,983) i... |
Coronavirus entry and release in polarized epithelial cells: a review | Most coronaviruses cause respiratory or intestinal infections in their animal or human host. Hence, their interaction with polarized epithelial cells plays a critical role in the onset and outcome of infection. In this paper, we review the knowledge regarding the entry and release of coronaviruses, with particular emph... |
Immobilization of Ulp1 protease on NHS-activated Sepharose: a useful tool for cleavage of the SUMO tag of recombinant proteins | OBJECTIVE: To fabricate an active and stable enzyme through covalent immobilization, a Ubl-specific protease (Ulp1) was used to cleave small ubiquitin-like modifier (SUMO) fusion proteins. RESULTS: We immobilized Ulp1 on N-hydroxysuccinimide (NHS)-activated Sepharose with a coupling efficiency of 1.7 mg/ml. The immobil... |
Estimating the reproductive number and the outbreak size of COVID-19 in Korea | OBJECTIVES: Since the first novel coronavirus disease 2019 (COVID-19) patient in Korea was diagnosed on January 20, 2020, 30 patients were diagnosed until February 17, 2020. However, 5,298 additional patients were confirmed until March 4, 2020. Therefore, our objective was to estimate the reproduction number (R) and ev... |
The Effectiveness and Mechanism of Toona sinensis Extract Inhibit Attachment of Pandemic Influenza A (H1N1) Virus | TSL-1 is a fraction of the aqueous extract from the tender leaf of Toona sinensis Roem, a nutritious vegetable. The pandemic influenza A (H1N1) virus is a recently described, rapidly contagious respiratory pathogen which can cause acute respiratory distress syndrome (ARDS) and poses a major public health threat. In thi... |
Neurological disease and encephalitis in cats experimentally infected with Borna disease virus | Barrier-bred cats were inoculated intracerebrally with either the rabbit-adapted Borna disease virus (BDV) strain V or a newly isolated feline BDV, obtained from a cat with natural staggering disease (SD). Three out of eight inoculated cats developed neurological signs and non-suppurative encephalitis; all three recove... |
Comparing Chinese children and adults with RT-PCR positive COVID-19: A systematic review | BACKGROUND: The various clinical manifestations of COVID-19 with RT-PCR positive patients have been reported. However, the differences in the clinical presentation between children and adults were unclear. Thus, we aimed to investigate the differences in the clinical manifestations and imaging characteristics between C... |
Challenges and recommendations for mental health providers during the COVID-19 pandemic: the experience of China’s First University-based mental health team | Coronavirus Disease is impacting the entire world. As the first country that has needed to confront this disease, China has responded with unprecedented and hugely successful public health initiatives. Almost simultaneous with the awareness of the potential for widespread loss of life, the first Chinese university reco... |
Comparison of visual and electronic devices for individual identification of dromedary camels under different farming conditions | The camel industry uses traditional (i.e., iron brands and ear tags) and modern (i.e., microchips) identification (ID) systems without having performance results of reference. Previously iron-branded (n = 45; 1 yr) and microchipped (n = 59; 7 yr) camels showed problems of healing (8.6% of brands) and reading (only 42.9... |
The ACE2‐deficient mouse: A model for a cytokine storm‐driven inflammation | Angiotensin converting enzyme 2 (ACE2) plays an important role in inflammation, which is attributable at least, in part, to the conversion of the pro‐inflammatory angiotensin (Ang) II peptide into angiotensin 1‐7 (Ang 1‐7), a peptide which opposes the actions of AngII. ACE2 and AngII are present in many tissues but inf... |
Diagnostic Reverse-Transcription Polymerase Chain Reaction Kit for Filoviruses Based on the Strain Collections of all European Biosafety Level 4 Laboratories | A network of European biosafety level 4 laboratories has designed the first industry-standard molecular assay for all filoviruses species, based on the strain collections of all participants. It uses 5 optimized L gene primers and 3 probes, as well as an internal control with a separate detection probe. Detection limit... |
Reflections arising from the COVID-19 pandemic | Abstract While we were drafting the recommendations for the joint contingency plan between the Spanish Society of Intensive Care and Coronary Unit Nursing (SEEIUC) and the Spanish Society of Intensive and Critical Care Medicine and Coronary Units (SEMICYUC), predictions were overtaken by events with regard to the magni... |
Estimating and modelling the transmissibility of Middle East Respiratory Syndrome CoronaVirus during the 2015 outbreak in the Republic of Korea | BACKGROUND: Emerging respiratory infections represent a significant public health threat. Because of their novelty, there are limited measures available to control their early spread. Learning from past outbreaks is important for future preparation. The Middle Eastern Respiratory Syndrome CoronaVirus (MERS‐CoV ) 2015 o... |
A novel European H5N8 influenza A virus has increased virulence in ducks but low zoonotic potential | We investigated in a unique setup of animal models and a human lung explant culture biological properties, including zoonotic potential, of a representative 2016 highly pathogenic avian influenza virus (HPAIV) H5N8, clade 2.3.4.4 group B (H5N8B), that spread rapidly in a huge and ongoing outbreak series in Europe and c... |
Pulmonary Aspergillosis: An Evolving Challenge for Diagnosis and Treatment | Aspergillus is a mold that may lead to different clinical pictures, from allergic to invasive disease, depending on the patient’s immune status and structural lung diseases. Chronic pulmonary aspergillosis is an infection with a locally invasive presentation, reported especially in patients with chronic pulmonary disea... |
Global Health Security in an Era of Global Health Threats | |
Identification of an immunorelevant ORF2 epitope from porcine circovirus type 2 as a serological marker for experimental and natural infection | Post-weaning multisystemic wasting syndrome (PMWS) is a recently identified disease of pigs linked to the emergence of a new porcine circovirus (PCV2). We report here the characterization of immunorelevant linear B-cell epitopes of the Open Reading Frame 2-encoded protein (Orf2) from PCV2 by an enzyme-linked immunosorb... |
Case report of a patient with suspected COVID-19 with depression and fever in an epidemic stress environment | During the COVID-19 pandemic, the number of suspected cases, confirmed cases and those who passed away from the virus has been reported in major media and the internet, and has caused a high degree of tension. In addition, people’s outdoor activities have been limited, making it more difficult to find outlets for relea... |
Screening of immune-related differentially expressed genes from primary lymphatic organs of broilers fed with probiotic bacillus cereus PAS38 based on suppression subtractive hybridization | To explore the molecular mechanism of the effect of Bacillus cereus PAS38 on the immunity of broilers, sixty 7-day-old broilers were divided into two groups with three replicates. The control group was fed with basal diet, and the treatment group was fed with basal diet containing Bacillus cereus PAS38 1×10(6) CFU/g. T... |
Computational identification of rare codons of Escherichia coli based on codon pairs preference | BACKGROUND: Codon bias is believed to play an important role in the control of gene expression. In Escherichia coli, some rare codons, which can limit the expression level of exogenous protein, have been defined by gene engineering operations. Previous studies have confirmed the existence of codon pair's preference in ... |
Origin and Evolution of the Kiwifruit Canker Pandemic | Recurring epidemics of kiwifruit (Actinidia spp.) bleeding canker disease are caused by Pseudomonas syringae pv. actinidiae (Psa). In order to strengthen understanding of population structure, phylogeography, and evolutionary dynamics, we isolated Pseudomonas from cultivated and wild kiwifruit across six provinces in C... |
A Focused Ethnographic Study of Alberta Cattle Veterinarians’ Decision Making about Diagnostic Laboratory Submissions and Perceptions of Surveillance Programs | The animal and public health communities need to address the challenge posed by zoonotic emerging infectious diseases. To minimize the impacts of future events, animal disease surveillance will need to enable prompt event detection and response. Diagnostic laboratory-based surveillance systems targeting domestic animal... |
1 Recurring Pitfalls in Hospital Preparedness and Response | Publisher Summary This chapter discusses the frequently occurring pitfalls in hospital preparedness and response. Significant systemic constraints make hospitals reluctant partners in preparedness and generate ineffective responses. Such a condition has been highlighted by the antiterrorism training and preparedness pr... |
An Antiviral Mechanism of Nitric Oxide Inhibition of a Viral Protease | Abstract Although nitric oxide (NO) kills or inhibits the replication of a variety of intracellular pathogens, the antimicrobial mechanisms of NO are unknown. Here, we identify a viral protease as a target of NO. The life cycle of many viruses depends upon viral proteases that cleave viral polyproteins into individual ... |
Rennen vliegen rust nemen | Hoge werkdruk, personeelstekorten, inspelen op acute - soms dramatische - situaties. Het verpleegkundig beroep gaat vaak gepaard met stress, helemaal in deze crisistijd.(*) Wat kun je daaraan doen? ‘Stress is niet altijd het grootste probleem; veel verpleegkundigen nemen onvoldoende hersteltijd.’ |
Epidemiological aspects of astrovirus and coronavirus in poults in the South Eastern Region of Brazil | A survey of Turkey Coronavirus (TCoV) and Astrovirus (TAstV-2) prevalence was carried out from February to December during 2006 year in semiarid region of Brazil, from a turkey producer area, localized in South Eastern of Brazil. To asses the risk factor related to clinical material, climatic condition and type of RT-P... |
Concept mapping as pre-task planning: A case study of three Japanese ESL writers | Abstract The majority of research to date on pre-task planning has investigated the impact of planning time on L2 learners’ oral production, and has generally reported its positive effects on their task performance. However, little research on planning has been conducted in writing contexts, and there is no firm eviden... |
In Case You Haven't Heard… | China reported a major drop in new coronavirus cases to 2,641 on Feb. 15, a decline after Chinese officials began implementing measures to contain the illness, and a slight increase in new deaths to 143, Fox News reported Feb. 16. The new figures bring the total number of deaths from the virus, now known as COVID‐19, t... |
Remote monitoring in clinical trials during the COVID‐19 pandemic | The COVID‐19 pandemic has rapidly challenged the pharmaceutical industry to implement remote clinical trials. The industry's lack of extensive experience with remote measurements initiates multiple questions about how to select candidates for remote collection, their validity, and regulatory implications of moving cert... |
Inhibitory C-type lectin receptors in myeloid cells | C-type lectin receptors encoded by the natural killer gene complex play critical roles in enabling NK cell discrimination between self and non-self. In recent years, additional genes at this locus have been identified with patterns of expression that extend to cells of the myeloid lineage where many of the encoded inhi... |
Diagnosis and treatment strategy of coronavirus disease 2019 with cardiovascular disease in elderly patients | |
An outbreak of COVID‐19 caused by a new coronavirus: what we know so far | |
Microarray Chip Based Identification of a Mixed Infection of Bovine Herpesvirus 1 and Bovine Viral Diarrhea 2 From Indian Cattle | Bovine herpesvirus 1 (BHV1) and bovine viral diarrhea virus 2 (BVD2) are endemic in India although no mixed infection with these viruses has been reported from India. We report first mixed infection of these viruses in cattle during routine screening with a microarray chip. 62 of the 69 probes of BHV1 and 42 of the 57 ... |
Synthetic Antibodies with a Human Framework That Protect Mice from Lethal Sudan Ebolavirus Challenge | [Image: see text] The ebolaviruses cause severe and rapidly progressing hemorrhagic fever. There are five ebolavirus species; although much is known about Zaire ebolavirus (EBOV) and its neutralization by antibodies, little is known about Sudan ebolavirus (SUDV), which is emerging with increasing frequency. Here we des... |
Influenza A☆ | Abstract The influenza viruses, which contain single-stranded RNA, are classified into 3 types, A, B, and C and belong to the Orthomyxoviridae family of viruses. Types A and B cause annual epidemics and often pandemics of influenza illness, while type C is a less common disease with fewer symptoms. |
Methods for air cleaning and protection of building occupants from airborne pathogens | Abstract This article aims to draw the attention of the scientific community towards the elevated risks of airborne transmission of diseases and the associated risks of epidemics or pandemics. The complexity of the problem and the need for multidisciplinary research is highlighted. The airborne route of transmission, i... |
What factors determine the survival of green innovative enterprises in China? - A method based on fsQCA | Increasingly serious environmental problems have generated a large number of small and medium-sized green innovative enterprises. Against the background of rapid technological changes and increasingly fierce market competition, survival is the main problem faced by these enterprises. Exploring the mechanisms and core e... |
Neurosurgery in Iraq at the Time of Corona | |
Pathogen evolution within host individuals as a primary cause of senescence | This paper discusses a novel theory of senescence: the community of pathogens within each host individual evolves during the life-time of the host, and in doing so progressively reduces host vigour. I marshal evidence that asymptomatic host individuals maintain persistent populations of viral pathogens; that these path... |
Preserving Operational Capability while Building Capacity during the COVID-19 Pandemic: A Tertiary Urology Centre's Experience | |
Viral evolution | Abstract In the last two decades, viruses have been used as model systems to study evolution in short periods of time. Due to their characteristics, virus adapt rapidly to changing conditions, thus allowing the quantification of several evolutionary features under controlled laboratory conditions. Here we review the ba... |
NF-κB activation by equine arteritis virus is MyD88 dependent and promotes viral replication | NF-κB, a family of transcription factors involved in different cell functions and immune responses is targeted by viruses. The mechanism of NF-κB signalling and its role in replication of EAV have not been investigated. We demonstrate that EAV infection in BHK-21 cells activates NF-κB, and this activation was found to ... |
Welcome to Infectious Disease Reports: a message from the Editor | |
Protection by Exclusion: Another Missed Opportunity to Include Pregnant Women in Research During the Coronavirus Disease 2019 (COVID-19) Pandemic | Coronavirus disease 2019 (COVID-19) is a novel infectious disease that started in Wuhan, China, and has rapidly spread all across the world. With limited ability to contain the virus and relatively high transmissibility and case fatality rates, governmental institutions and pharmaceutical companies are racing to find t... |
Efficacy, Safety, and Pharmacokinetics of a New 10 % Liquid Intravenous Immunoglobulin Containing High Titer Neutralizing Antibody to RSV and Other Respiratory Viruses in Subjects with Primary Immunodeficiency Disease | PURPOSE: Immune globulins for IgG supplementation have been produced for over 35 years with essentially no differentiating features regarding their specific antibody composition. Furthermore, the compositions of plasma donor pools used for IG manufacturing are not standardized. While all immune globulin products meet t... |
Coronavirus 229E-Related Pneumonia in Immunocompromised Patients | Coronaviruses strains 229E and OC43 have been associated with various respiratory illnesses ranging from the self-resolving common cold to severe pneumonia. Although chronic underlying conditions are major determinants of severe respiratory virus infections, few data about coronavirus-related pneumonia in immunocomprom... |
Letter to the editor in response to the article: “Is diabetes mellitus associated with mortality and severity of COVID-19? A meta-analysis (Kumar et al.)” | |
COVID‐19 infection in children and adolescents with cancer in Madrid | |
Frailty and COVID-19: A Systematic Scoping Review | Older people have paid a huge toll in terms of mortality during the coronavirus disease-19 (COVID-19) pandemic Frailty may have contributed to the vulnerability of older people to more severe clinical presentation We aimed at reviewing available evidence about frailty and COVID-19 We searched PUBMED, Web of Science, an... |
Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses | RNA viruses encode an RNA-dependent RNA polymerase (RdRp) that catalyzes the synthesis of their RNA(s). In the case of positive-stranded RNA viruses belonging to the order Nidovirales, the RdRp resides in a replicase subunit that is unusually large. Bioinformatics analysis of this non-structural protein has now reveale... |
Negative impact of hyperglycaemia on tocilizumab therapy in Covid-19 patients | Abstract Tocilizumab (TCZ) is used for treating moderate-to-severe Covid-19 pneumonia by targeting interleukin-6 receptors (IL-6Rs) and reducing cytokine release. Yet, in spite of this therapy, patients with vs patients without diabetes have an adverse disease course. In fact, glucose homoeostasis has influenced the ou... |
Epidemiology of severe acute respiratory infections from hospital-based surveillance in Madagascar, November 2010 to July 2013 | BACKGROUND: Few comprehensive data exist regarding the epidemiology of severe acute respiratory infections (SARI) in low income countries. This study aimed at identifying etiologies and describing clinical features of SARI-associated hospitalization in Madagascar. METHODS: It is a prospective surveillance of SARI in 2 ... |
Epidemiological characteristics of COVID-19 patients in convalescence period | This study aimed to investigate the clinical characteristics and to analyse the epidemiological features of coronavirus disease 2019 (COVID-19) patients during convalescence. In this study, we enrolled 71 confirmed cases of COVID-19 who were discharged from hospital and transferred to isolation wards from 6 February to... |
May COVID-19 outbreaks lead to a worsening of skin chronic inflammatory conditions? | The emergence of the novel beta Coronavirus has raised serious concerns due to the virus rapid dissemination worldwide. Many areas throughout the world are now experiencing the COVID 19 outbreaks with government and policy authorities taking many aggressive isolation or restriction measures, drastically reducing also p... |
Challenges and Responsibilities in Caring for the Most Vulnerable During the COVID‐19 Pandemic | |
Curso clínico de la COVID-19 en pacientes con hipertensión arterial pulmonar | |
As ACA marks 10th anniversary, MH care even more critical during COVID‐19 | March 23, 2020, marked the 10th anniversary of the Affordable Care Act (ACA), which, despite some ups and downs over the past decade, has expanded the scope of coverage for millions of people with mental illnesses and substance use disorders (SUDs). |
Development of a negative pressure hood for isolation and transportation of individual patient with respiratory infectious disease | Abstract The frequent and sudden occurrence of both known and unknown infectious diseases can cause global social panic. If the source of infection can be effectively controlled in the early stages of an outbreak, the spread of infectious diseases can be prevented. In view of this situation, this study developed for in... |
Current awareness on yeast | In order to keep subscribers up‐to‐date with the latest developments in their field, this current awareness service is provided by John Wiley & Sons and contains newly‐published material on yeasts. Each bibliography is divided into 10 sections. 1 Books, Reviews & Symposia; 2 General; 3 Biochemistry; 4 Biotechnology; 5 ... |
Mysterious Virus: A Review on Behavior and Treatment Approaches of the Novel Coronavirus, 2019-nCoV | Abstract At the end of the year 2019, the novel coronavirus (2019-nCoV) was spreading in Wuhan, China, and the outbreak process has a high speed. It was recognized as a pandemic by the World Health Organization (WHO) on 11 March 2020. Coronaviruses are enveloped and single-stranded RNA that have several families includ... |
A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease | Live-attenuated RNA virus vaccines are efficacious but subject to reversion to virulence. Among RNA viruses, replication fidelity is recognized as a key determinant of virulence and escape from antiviral therapy; increased fidelity is attenuating for some viruses. Coronavirus replication fidelity is approximately 20-fo... |
COVID-19 and Crimean Congo Hemorrhagic Fever: Similarities and Differences | |
Frequency of Common Viruses in Etiology of Acute Respiratory Tract Infections | OBJECTIVE: To determine the frequency rate of C. pneumoniae, rhinovirus, respiratory syncytial virus (RSV), influenza virus, metapneumovirus, adenovirus’, parainfluenza virus and coronavirus in acute respiratory tract infections in children. METHODS: One hundred nine pediatric patients having respiratory tract infectio... |
Chapter Eleven Communicating During a Public Health Crisis | “Communicating during a Public Health Crisis,” examines how communicating to the public and media during a public health or safety emergency is different. In a serious crisis, all affected people take in information differently, process information differently and act on information differently. This chapter incorporat... |
Any unique image biomarkers associated with COVID-19? | OBJECTIVE: To define the uniqueness of chest CT infiltrative features associated with COVID-19 image characteristics as potential diagnostic biomarkers. METHODS: We retrospectively collected chest CT exams including n = 498 on 151 unique patients RT-PCR positive for COVID-19 and n = 497 unique patients with community-a... |
Skin manifestations in COVID‐19: A case series of five patients from Elazığ, Turkey | |
A novel CDPK1 inhibitor—a potential treatment for cryptosporidiosis in calves? | Cryptosporidium parvum is a zoonotic agent that infects humans and animals occasionally causing severe, watery diarrhoea. In immunocompetent hosts, cryptosporidiosis is self-limiting but can have a fatal outcome in immunocompromised individuals. Cryptosporidium is one of the most common causes of waterborne diseases (r... |
Psychological Resilience During the COVID-19 Lockdown | Some individuals are more psychologically resilient to adversity than others, an issue of great importance during the emerging mental health issues associated with the COVID-19 pandemic. To identify factors that may contribute to greater psychological resilience during the first weeks of the nation-wide lockdown effort... |
OUTBREAK OF COVID-19 IN A NURSING HOME IN MADRID | |
Vaccines for emerging pathogens: from research to the clinic | In this two‐part series of reviews, we have invited experts in their fields to contribute articles on the status of vaccine research and development for emerging pathogens. This topic has been brought into sharp focus in recent years following significant outbreaks of viral diseases such as those causing severe acute r... |
RETRACTED: Efficacy of novel antibody-based drugs against rhinovirus infection: In vitro and in vivo results | This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor in Chief. This article claimed to demonstrate the antiviral activity of ®Anaferon and ®Ergoferon again... |
Therapeutic Immunoglobulin Selected for High Antibody Titer to RSV also Contains High Antibody Titers to Other Respiratory Viruses | Specific antibodies against infections most relevant to patients with primary immunodeficiency diseases are not routinely evaluated in commercial polyclonal immunoglobulin preparations. A polyclonal immunoglobulin prepared from plasma of donors having high neutralizing antibody titers to respiratory syncytial virus (RS... |
World Union of Wound Healing Societies Meeting, 2020 | |
The efficacy of herbal therapy on quality of life in patients with breast cancer: self-control clinical trial | BACKGROUND: Mounting evidence indicates that herbal therapy is effective in alleviating anxiety, lessening cancer treatment-related side-effects, and facilitating rehabilitation. This is the first trial to examine the herbal therapy of combined yunzhi and danshen on quality of life among breast cancer patients. METHODS... |
Virome Profiling of Bats from Myanmar by Metagenomic Analysis of Tissue Samples Reveals More Novel Mammalian Viruses | Bats are reservoir animals harboring many important pathogenic viruses and with the capability of transmitting these to humans and other animals. To establish an effective surveillance to monitor transboundary spread of bat viruses between Myanmar and China, complete organs from the thorax and abdomen from 853 bats of ... |
Discovery of Hepatitis C Virus NS3 Helicase Inhibitors by a Multiplexed, High‐Throughput Helicase Activity Assay Based on Graphene Oxide | A GO‐to solution: A simple graphene oxide (GO)‐based assay to screen for selective inhibitors of a hepatitis C virus (HCV) helicase along with inhibitors of a severe acute respiratory syndrome coronavirus (SARS CoV) helicase was tested (see scheme). A single screen found five inhibitors highly selective for the HCV hel... |
Lectins from red algae and their biomedical potential | Lectins are unique proteins or glycoproteins of non-immune origin that bind specifically to carbohydrates. They recognise and interact reversibly to either free carbohydrates or glycoconjugates, without modifying their structure. Lectins are highly diverse and widely distributed in nature and have been extensively repo... |
"Transition to on‐line is possible: solution for simulation‐based teaching during pandemic" | In March 2020, Polish universities had to suspend all on‐site activities due to the SARS‐CoV‐2 pandemic. As a result, we were faced with the problem of how to convert a simulation‐based course in geriatrics into distance‐learning. The main focus of the original course (30 academic hours) is to expose fourth‐year medica... |
Encephalopathy only stroke codes (EoSC) do not result in rt-PA treatments | BACKGROUND: Isolated mental status changes as a presenting sign (EoSC+), are not uncommon stroke code triggers. As stroke alerts, they still require the same intensive resources be applied. We previously showed that EoSC+ strokes (EoSC+ Stroke+) account for 0.1–0.2% of all codes. Whether these result in thrombolytic tr... |
Effect of acute respiratory infections in infancy on pulmonary function test at 3 years of age: a prospective birth cohort study | INTRODUCTION: Acute respiratory infections (ARIs) in infancy may have a long-term impact on the developing respiratory system. We planned a prospective cohort study to determine the impact of ARI during infancy on the pulmonary function test indices at 3 years of age. METHODS: A cohort of normal, full-term newborns wer... |
Chapter 16 Carbohydrate Microarrays as Essential Tools of Postgenomic Medicine | Publisher Summary Carbohydrates are essential biological molecules carrying important biological information. Carbohydrates are prominently displayed on the surface of cell membranes and expressed by virtually all secretory proteins in bodily fluids. This is achieved by the events of posttranslational protein modificat... |
The ecology and adaptive evolution of influenza A interspecies transmission | Since 2013, there have been several alarming influenza‐related events; the spread of highly pathogenic avian influenza H5 viruses into North America, the detection of H10N8 and H5N6 zoonotic infections, the ongoing H7N9 infections in China and the continued zoonosis of H5N1 viruses in parts of Asia and the Middle East.... |
Signal of Increased Opioid Overdose during COVID-19 from Emergency Medical Services Data | BACKGROUND: Individuals with opioid use disorder may be at heightened risk of opioid overdose during the COVID-19 period of social isolation, economic distress, and disrupted treatment services delivery. This study evaluated changes in daily number of Kentucky emergency medical services (EMS) runs for opioid overdose b... |
Oligomerized transferrin receptors are selectively retained by a lumenal sorting signal in a long-lived endocytic recycling compartment | Cross-linking of surface receptors results in altered receptor trafficking in the endocytic system. To better understand the cellular and molecular mechanisms by which receptor cross-linking affects the intracellular trafficking of both ligand and receptor, we studied the intracellular trafficking of the transferrin re... |
Studying Coronavirus–Host Protein Interactions | To understand the molecular mechanisms of viral replication and pathogenesis, it is necessary to establish the virus–host protein interaction networks. The yeast two-hybrid system is a powerful proteomic approach to study protein–protein interactions. After the identification of specific cellular factors interacting wi... |
Détection, quantification et analyse des génomes viraux dans les infections à herpèsvirus humains 6 et 7 (HHV-6, HHV-7) | Résumé La détection, la quantification et l’analyse génétique des génomes viraux ont été progressivement introduites dans la pratique quotidienne de la virologie médicale. Dans le cas des infections à herpèsvirus humains 6 et 7 (HHV-6, HHV-7), la détection de l’ADN viral a permis d’impliquer ces infections dans des mal... |
Des propositions pragmatiques pour le suivi respiratoire des patients après une infection à SARS-CoV-2 établies en un temps record à destination de tous les professionnels de santé | |
Trends of participation of post-graduate year training program for dentists in Taiwan dental training institutions from 2010 to 2018 | BACKGROUND/PURPOSE: The licensed dentists in Taiwan should join the post-graduate year training program for dentists (PGYD) since 2010. This study aimed to analyze the project types and the geographical distribution of the PGYD training institutions in Taiwan from 2010 to 2018. MATERIALS AND METHODS: From 2010 to 2018,... |
Chapter 11 Pathology The Clinical Description of Human Disease | …Future discoveries will not likely be made by morphologists ignorant of molecular biologic findings, or by biologists unaware or scornful of morphologic data, but by those willing and capable of integrating them through a team approach… Rosai [1]. |
Chapter 5 Innate Humoral Defense Factors | |
Prevalence and complete genome of bovine norovirus with novel VP1 genotype in calves in China | Bovine norovirus (BNoV) is a diarrhea-causing pathogen of calves. In this study, 211 diarrheic fecal samples were collected from 25 farms across six provinces in China, between November 2017 and September 2018. 20.4% of the samples were detected as BNoV-positive by RT-PCR. Phylogenetic analyses based on RdRp, VP1, and ... |
Maternal choline and respiratory coronavirus effects on fetal brain development | Prenatal COVID-19 infection is anticipated by the U.S. Centers for Disease Control to affect fetal development similarly to other common respiratory coronaviruses through effects of the maternal inflammatory response on the fetus and placenta. Plasma choline levels were measured at 16 weeks gestation in 43 mothers who ... |
Respiratory Presentation of Pediatric Patients in the 2014 Enterovirus D68 Outbreak | Background. In the fall of 2014, a North American outbreak of enterovirus D68 resulted in a significant number of pediatric hospital admissions for respiratory illness throughout North America. This study characterized the clinical presentation and risk factors for a severe clinical course in children admitted to Briti... |
Severe Systemic Calciphylaxis in a Young Cat | |
Plagues and adaptation: Lessons from the Felidae models for SARS and AIDS | Abstract Research studies of infectious disease outbreaks in wild species of the cat family Felidae have revealed unusual details regarding forces that shape population survival and genetic resistance in these species. A highly virulent feline coronavirus epidemic in African cheetahs, a disease model for human SARS, il... |
Effect of hydroxychloroquine on prevention of COVID-19 virus infection among healthcare professionals: a structured summary of a study protocol for a randomised controlled trial | OBJECTIVES: Comparison of the effect of hydroxychloroquine with placebo to prevent infection from the COVID -19 virus among healthcare professionals TRIAL DESIGN: Single centre, 2-arm, double-blind randomised (ratio 1:1) placebo-controlled trial PARTICIPANTS: Treatment staff who are in contact with patients and have at... |
Genetic and Molecular Biological Analysis of Protein-Protein Interactions in Coronavirus Assembly | |
Leader Sequence | Abstract The region of a messenger RNA (mRNA) molecule that precedes the coding sequence of a gene is called the ‘leader sequence’. This region is also known as the ‘five prime untranslated region’ (Figure 1) of the mRNA. Leader sequences have the propensity for forming secondary structures (stem-loops) by base pairing... |
Outbreak of acute febrile respiratory illness caused by human adenovirus B P14H11F14 in a military training camp in Shandong China | This study reports an outbreak of acute febrile respiratory illness caused by human adenovirus B [P14H11F14] in a military training center in China between May and June 2014. In total, 164 military personnel were affected, and two patients were admitted into the intensive care unit of the military regional central hosp... |
Specific coagulation markers may provide more therapeutic targets in COVID‐19 patients receiving prophylactic anticoagulant | I read with interest the recent published article from Professor Robert L. Medcalf, entitled “Fibrinolysis and COVID‐19: a plasmin paradox” [1]. As an indirect marker of thrombin and plasmin activation, D‐dimer has been suggested to guide anticoagulant treat in COVID‐19 patients [2, 3]. However, D‐dimer may not be able... |
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