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A Roadmap to Reopening a Neurosurgical Practice in the age of COVID-19 | Abstract The Coronavirus Disease 2019 (COVID-19) outbreak has left a lasting mark on medicine globally. Here we outline the steps that the Lenox Hill Hospital/Northwell Health Neurosurgery Department—located within the epicenter of the pandemic in New York City—is currently taking to recover our neurosurgical efforts i... |
Detection and characterisation of novel bocavirus (genus Bocaparvovirus) and gastroenteritis viruses from asymptomatic pigs in Ireland | BACKGROUND: Livestock animals have been the assumed source of several human epidemics in recent years, for example, influenza H1N1, rotavirus G8/G9, and MERS-CoV. Surveillance of novel viruses in animals is essential to evaluate the risk to human and animal health and to determine any economic impact, for example, fail... |
Alcohol and isolation: Experts comment on drinking behavior during COVID‐19 | Are people drinking more now that they are locked in a house with their nearest and dearest, facing job loss or having lost a job, bored and stressed? Probably. Is drinking a healthy way of coping? No. |
Hemagglutination by calf diarrhea coronavirus | Abstract The virus was grown in BEK-1 cells, a stable cell line from bovine embryo kidney, and tested for hemagglutination (HA) with erythrocytes of a variety of species at 4°C, room temperature and 37°C. HA was observed at all temperatures with chicken, mouse, rat, and hamster erythrocytes but not with erthyrocytes of... |
Large Arf1 guanine nucleotide exchange factors: evolution, domain structure, and roles in membrane trafficking and human disease | The Sec7 domain ADP-ribosylation factor (Arf) guanine nucleotide exchange factors (GEFs) are found in all eukaryotes, and are involved in membrane remodeling processes throughout the cell. This review is focused on members of the GBF/Gea and BIG/Sec7 subfamilies of Arf GEFs, all of which use the class I Arf proteins (A... |
Two‐year prospective study of single infections and co‐infections by respiratory syncytial virus and viruses identified recently in infants with acute respiratory disease | A prospective 2‐year analysis including 322 infant patients with acute respiratory disease (ARD) hospitalized in a pediatric department in northern Italy was carried out to evaluate the role as respiratory pathogens or co‐pathogens of recently identified viruses. The presence of respiratory syncitial virus (RSV), human... |
Analysis of clinical features and outcomes of 161 patients with severe and critical COVID‐19: A multicenter descriptive study | BACKGROUND: This study aimed to investigate clinical characteristics, laboratory indexes, treatment regimens, and short‐term outcomes of severe and critical coronavirus disease 2019 (COVID‐19) patients. METHODS: One hundred and sixty one consecutive severe and critical COVID‐19 patients admitted in intensive care unit ... |
Identification of a Conserved Non-Protein-Coding Genomic Element that Plays an Essential Role in Alphabaculovirus Pathogenesis | Highly homologous sequences 154–157 bp in length grouped under the name of “conserved non-protein-coding element” (CNE) were revealed in all of the sequenced genomes of baculoviruses belonging to the genus Alphabaculovirus. A CNE alignment led to the detection of a set of highly conserved nucleotide clusters that occup... |
Management of Leprosy Patients in the Era of COVID19 | |
Chapter 3 Features of Host Cells Cellular and Molecular Biology Review | Abstract As obligate intracellular parasites, viruses are completely dependent upon a host cell for their replication. They use energy generated by the host cell, and they exploit the host's machinery to manufacture viral proteins. Many of the cell's organelles, as well as the plasma membrane, are involved in viral rep... |
La consulta telemática para el cardiólogo clínico en tiempos de la COVID-19: presente y futuro. Documento de consenso de la Sociedad Española de Cardiología | RESUMEN La pandemia producida por la infección por el coronavirus SARS-CoV-2 (COVID-19) ha cambiado la forma de entender nuestras consultas. Para reducir el riesgo de contagio de los pacientes más vulnerables (aquellos con cardiopatías) y del personal sanitario, se han suspendido la mayoría de las consultas presenciale... |
The psychological impact of COVID-19 pandemic on the general population of Saudi Arabia | BACKGROUND: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging infection causing a widely spread pandemic of Coronavirus disease 2019 (COVID-19). The current COVID-2019 pandemic is prompting fear of falling sick, dying, helplessness and stigma, urgent and timely understanding of mental heal... |
Rheum emodin inhibits enterovirus 71 viral replication and affects the host cell cycle environment | Human enterovirus 71 (EV71) is the primary causative agent of recent large-scale outbreaks of hand, foot, and mouth disease (HFMD) in Asia. Currently, there are no drugs available for the prevention and treatment of HFMD. In this study, we compared the anti-EV71 activities of three natural compounds, rheum emodin, arte... |
Analysis of international tourist arrivals in China: The role of World Heritage Sites | This paper analyzes the determinants of international tourist arrivals in China, especially for World Heritage Sites and various kinds of travel spots. Utilizing annual provincial panel data over the 2000–2005 period, the empirical results suggest that key determinants include the relative income, population in the ori... |
Non-Molecular-Clock-Like Evolution following Viral Origins in Homo sapiens | Researchers routinely adopt molecular clock assumptions in conducting sequence analyses to estimate dates for viral origins in humans. We used computational methods to examine the extent to which this practice can result in inaccurate ‘retrodiction.’ Failing to account for dynamic molecular evolution can affect greatly... |
Co‐chaperone BAG3 and adenovirus penton base protein partnership | The BAG family of Hsp70/Hsc70 co‐chaperones is characterised by the presence of a conserved BAG domain at the carboxyl‐terminus. BAG3 protein is the only member of this family containing also the N‐terminally located WW domain. We describe here the identification of adenovirus (Ad) penton base protein as the first BAG3... |
The potential danger of suboptimal antibody responses in COVID-19 | There is a desperate need for effective therapies and vaccines for SARS-CoV-2 to mitigate the growing economic crisis that has ensued from societal lockdown. Vaccines are being developed at an unprecedented speed and are already in clinical trials, without preclinical testing for safety and efficacy. Yet, safety evalua... |
What does ‘leave no one behind’ mean for humanitarian crises-affected populations in the COVID-19 pandemic? | |
Models of cytokine dynamics in the inflammatory response of viral zoonotic infectious diseases | Inflammatory responses to an infection from a zoonotic pathogen, such as avian influenza viruses, hantaviruses and some coronaviruses, are distinctly different in their natural reservoir versus human host. While not as well studied in the natural reservoirs, the pro-inflammatory response and viral replication appear co... |
Report of the second international conference on next generation sequencing for adventitious virus detection in biologics for humans and animals() | The IABS-EU, in association with PROVAXS and Ghent University, hosted the “2(nd) Conference on Next Generation Sequencing (NGS) for Adventitious Virus Detection in Human and Veterinary Biologics” held on November 13(th) and 14(th) 2019, in Ghent, Belgium. The meeting brought together international experts from regulato... |
The Clinical Nurse Leader and COVID-19: Leadership and quality at the point of care | |
Securing Internet of Medical Things with Friendly-jamming schemes | The Internet of Medical Things (IoMT)-enabled e-healthcare can complement traditional medical treatments in a flexible and convenient manner. However, security and privacy become the main concerns of IoMT due to the limited computational capability, memory space and energy constraint of medical sensors, leading to the ... |
Towards a computational model for −1 eukaryotic frameshifting sites | Motivation: Unconventional decoding events are now well acknowledged, but not yet well formalized. In this study, we present a bioinformatics analysis of eukaryotic −1 frameshifting, in order to model this event. Results: A consensus model has already been established for −1 frameshifting sites. Our purpose here is to ... |
Immunoregulation with mTOR inhibitors to prevent COVID‐19 severity: A novel intervention strategy beyond vaccines and specific antiviral medicines | Coronavirus disease 2019 (COVID‐19) has become a major global public health concern. The mortality rate for critically ill patients is up to 60%, and, thus, reducing the disease severity and case mortality is a top priority. Currently, cytokine storms are considered as the major cause of critical illness and death due ... |
How Is WHO Responding to Global Public Health Threats? | The editors discuss two recent WHO initiatives on preparing for and responding to global public health threats: the WHO Rapid Advice Guidelines Group and the new revision of the International Health Regulations. |
Rationale for universal face masks in public against COVID‐19 | |
Antibioprophylaxie dans le cadre d'interventions obstétricales | OBJECTIF: Analyser les résultats et formuler des recommandations sur le recours à l'antibioprophylaxie dans le cadre d'interventions obstétricales. ISSUES: Parmi les issues évaluées, on trouve la nécessité et l'efficacité du recours à des antibiotiques aux fins de la prévention des infections dans le cadre d'interventi... |
Evaluating the promise of recombinant transmissible vaccines | Transmissible vaccines have the potential to revolutionize infectious disease control by reducing the vaccination effort required to protect a population against a disease. Recent efforts to develop transmissible vaccines focus on recombinant transmissible vaccine designs (RTVs) because they pose reduced risk if intra-... |
Vitamin D deficiency and co-morbidities in COVID-19 patients – A fatal relationship? | |
Community Epidemiology Framework for Classifying Disease Threats | Recent evidence suggests that most parasites can infect multiple host species and that these are primarily responsible for emerging infectious disease outbreaks in humans and wildlife. However, the ecologic and evolutionary factors that constrain or facilitate such emergences are poorly understood. We propose a concept... |
Diagnostic Techniques: Serological and Molecular Approaches☆ | Abstract Virus laboratory diagnostics has an increasingly important role in modern patient care. Virological methods are needed to investigate the etiology of acute viral infection or the reactivation of a latent infection, as well as to follow virus load in antiviral treatments. Serological assays are also used for sc... |
Incidence and consequences of systemic arterial thrombotic events in COVID-19 patients | A high incidence of thrombotic events, particularly deep vein thrombosis and pulmonary embolism, has been clearly documented in COVID-19 patients. In addition, small series of patients with coronary, cerebrovascular and peripheral arterial thrombotic events have also been reported, but their true incidence and conseque... |
U-08: Gestion des infections à MERS-CoV : expérience au CHRU de Lille | Introduction – objectifs Deux patients atteints de MERS-CoV (Middle East Respiratory Syndrome-Coronavirus) ont été hospitalisés en France en 2013. L’un d’eux a été pris en charge dans notre unité de Maladies Infectieuses (UMI). L’objectif de ce travail est de décrire et évaluer l’organisation pratique et les mesures de... |
Habitat for Humanity cuts staff amid COVID‐19 pandemic | |
High-level expression of the HIV entry inhibitor griffithsin from the plastid genome and retention of biological activity in dried tobacco leaves | KEY MESSAGE: The potent anti-HIV microbicide griffithsin was expressed to high levels in tobacco chloroplasts, enabling efficient purification from both fresh and dried biomass, thus providing storable material for inexpensive production and scale-up on demand. ABSTRACT: The global HIV epidemic continues to grow, with ... |
Genome sequence and origin analyses of the recombinant novel IBV virulent isolate SAIBK2 | Recombination between infectious bronchitis viruses (IBVs), together with point mutations, insertions, and deletions, is thought to be responsible for the emergence of new IBV variants. SAIBK2 is a nephropathogenic strain isolated from layer flocks vaccinated with live attenuated H120 vaccine in Sichuan province, China... |
Promoter Variation in the DC-SIGN–Encoding Gene CD209 Is Associated with Tuberculosis | BACKGROUND: Tuberculosis, which is caused by Mycobacterium tuberculosis, remains one of the leading causes of mortality worldwide. The C-type lectin DC-SIGN is known to be the major M. tuberculosis receptor on human dendritic cells. We reasoned that if DC-SIGN interacts with M. tuberculosis, as well as with other patho... |
A review on the cleavage priming of the spike protein on coronavirus by angiotensin-converting enzyme-2 and furin | The widespread antigenic changes lead to the emergence of a new type of coronavirus (CoV) called as severe acute respiratory syndrome (SARS)-CoV-2 that is immunologically different from the previous circulating species. Angiotensin-converting enzyme-2 (ACE-2) is one of the most important receptors on the cell membrane ... |
Current progress in CRISPR‐based diagnostic platforms | The CRISPR‐Cas system is a key technology for genome editing and regulation in a wide range of organisms and cell types. Recently, CRISPR‐Cas–based diagnostic platform has shown idealistic properties for pathogen detection. Integrating the CRISPR‐Cas platform along with lateral flow system allows rapid, sensitive, spec... |
Cytoplasmic Viruses: Rage against the (Cellular RNA Decay) Machine | |
Detection of Zika virus using reverse-transcription LAMP coupled with reverse dot blot analysis in saliva | In recent years, there have been increasing numbers of infectious disease outbreaks that spread rapidly to population centers resulting from global travel, population vulnerabilities, environmental factors, and ecological disasters such as floods and earthquakes. Some examples of the recent outbreaks are the Ebola epid... |
Identifying Small Molecules That Promote Quasipalindrome-Associated Template-Switch Mutations in Escherichia coli | DNA can assemble into non-B form structures that stall replication and cause genomic instability. One such secondary structure results from an inverted DNA repeat that can assemble into hairpin and cruciform structures during DNA replication. Quasipalindromes (QP), imperfect inverted repeats, are sites of mutational ho... |
The liver injury and gastrointestinal symptoms in patients with Coronavirus Disease 19: a systematic review and meta-analysis | Abstract Backgrounds: Since December 2019, novel coronavirus (SARS-CoV-2)-infected pneumonia (COVID-19) occurred in Wuhan, and rapidly spread throughout China. Our study aimed to evaluate the association of liver injury and gastrointestinal symptoms (GIS) with the progression of COVID-19. Methods: A comprehensive searc... |
Nuclear imprisonment of host cellular mRNA by nsp1β protein of porcine reproductive and respiratory syndrome virus | Abstract Positive-strand RNA genomes function as mRNA for viral protein synthesis which is fully reliant on host cell translation machinery. Competing with cellular protein translation apparatus needs to ensure the production of viral proteins, but this also stifles host innate defense. In the present study, we showed ... |
Implication of COVID‐19 in oral oncology practices in Brazil, Canada and the United States | The newly emerged Coronavirus disease 2019 (COVID‐19) is an infectious disease that has spread rapidly throughout the world. The most common signs and symptoms are fever, dry cough and shortness of breath which can progress to severe viral pneumonia and multi‐organ failure in susceptive patients (Chen et al. 2020, Wang... |
Advances in Mast Cell Activation by IL-1 and IL-33 in Sjögren’s Syndrome: Promising Inhibitory Effect of IL-37 | Sjögren’s syndrome (SS) is a chronic autoimmune inflammatory disease that affects primarily older women and is characterized by irreversible damage of the exocrine glands, including tear (xerophthalmia) and salivary glands (xerostomia). Secretory glands lose their functionality due to the infiltration of immune cells, ... |
Computational identification of biologically functional non-hairpin GC-helices in human Argonaute mRNA | BACKGROUND: Perfectly formed duplex elements in RNA occur within folding units, often as a part of hairpin motifs which can be reliably predicted by various RNA folding algorithms. Double helices with consecutive Watson-Crick base-pairing may also be formed between distant RNA segments thereby facilitating long-range i... |
Diffuse cutaneous manifestation in a new mother with COVID‐19 (SARS‐Cov‐2) | |
Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study | Summary Background We previously showed that small interfering RNAs (siRNAs) targeting the Zaire Ebola virus (ZEBOV) RNA polymerase L protein formulated in stable nucleic acid-lipid particles (SNALPs) completely protected guineapigs when administered shortly after a lethal ZEBOV challenge. Although rodent models of ZEB... |
High-resolution CT features of the COVID-19 infection in Nanchong City: Initial and follow-up changes among different clinical types | OBJECTIVE: To discuss the high resolution computed tomography (HRCT) manifestations of coronavirus disease 2019 (COVID-19) patients among different clinical types on initial and follow-up CT. METHODS: Seven COVID-19 patients admitted to the Affiliated Hospital of North Sichuan Medical Collage were enrolled. All patient... |
Perioperative planning in the COVID-19 pandemic: Cardiovascular perfusion and device-related issues. | |
Methods and approaches to disease mechanisms using systems kinomics | All cellular functions, ranging from regular cell maintenance and homeostasis, specialized functions specific to cellular types, or generating responses due to external stimulus, are mediated by proteins within the cell. Regulation of these proteins allows the cell to alter its behavior under different circumstances. A... |
Clinical presentation, diagnostic findings and outcome in dogs diagnosed withpresumptive spinal‐only meningoen‐cephalomyelitis of unknown origin | OBJECTIVES: To summarise clinical presentation, diagnostic findings and long‐term outcome for dogs clinically diagnosed with meningoencephalomyelitis of unknown origin affecting the spinal cord alone. METHODS: Medical records were reviewed for dogs diagnosed with presumptive spinal‐only meningoencephalomyelitis of unkn... |
‘Distancers’ and ‘non‐distancers’? The potential social psychological impact of moralizing COVID‐19 mitigating practices on sustained behaviour change | COVID‐19 mitigating practices such as ‘hand‐washing’, ‘social distancing’, or ‘social isolating’ are constructed as ‘moral imperatives’, required to avert harm to oneself and others. Adherence to COVID‐19 mitigating practices is presently high among the general public, and stringent lockdown measures supported by legal... |
Determinants of safety-focused product purchasing in the United States at the beginning of the global COVID-19 pandemic | Public preparation for the COVID-19 pandemic was widely covered in the media due to its intensity and fast-pace. While some individuals prepared with personal safety supplies such as soap and hand sanitizer, many others did not purchase such preparatory products. There are many health and safety benefits to quick engag... |
22 Role of Dynein in Viral Pathogenesis | Publisher Summary This chapter describes the state of the art machineries that viruses use from viral infection (entry) to the end stage, when new, progeny virus particles disseminate from cells. The development of drugs that target dynein activities during viral replication rely on the disruption of characterized and ... |
Protecting health workers from infectious disease transmission: an exploration of a Canadian-South African partnership of partnerships | BACKGROUND: Health workers are at high risk of acquiring infectious diseases at work, especially in low and middle-income countries (LMIC) with critical health human resource deficiencies and limited implementation of occupational health and infection control measures. Amidst increasing interest in international partne... |
How long does Coronavirus survive on different surfaces? | Dental practices now need to be more vigilant than ever and pay extra attention to hygiene in the surgery Hospitals are currently operating an hourly total clean policy and it would be prudent for dental practices to look to operate something similar to reduce the possibility of viral transmission The Government is enc... |
Ontario issues final SARS Commission report | |
Ribosomal frameshifting used in influenza A virus expression occurs within the sequence UCC_UUU_CGU and is in the +1 direction | Programmed ribosomal frameshifting is used in the expression of many virus genes and some cellular genes. In eukaryotic systems, the most well-characterized mechanism involves –1 tandem tRNA slippage on an X_XXY_YYZ motif. By contrast, the mechanisms involved in programmed +1 (or −2) slippage are more varied and often ... |
Comparison of Clinical Characteristics of Patients with Asymptomatic vs Symptomatic Coronavirus Disease 2019 in Wuhan, China | This case series examines clinical characteristics of patients with asymptomatic vs symptomatic coronavirus disease 2019 in Wuhan, China. |
The fecal microbiota of healthy donor horses and geriatric recipients undergoing fecal microbial transplantation for the treatment of diarrhea | BACKGROUND AND AIMS: Fecal microbial transplantation (FMT), a treatment for certain gastrointestinal conditions associated with dysbiosis in people, is also empirically employed in horses with colitis. This study used microbiota high-throughput sequencing to compare the fecal microbial profile of healthy horses to that... |
Treatment of severely ill COVID-19 patients with anti-interleukin drugs (COV-AID): A structured summary of a study protocol for a randomised controlled trial | OBJECTIVES: The purpose of this study is to test the safety and effectiveness of individually or simultaneously blocking IL-6, IL-6 receptor and IL-1 versus standard of care on blood oxygenation and systemic cytokine release syndrome in patients with COVID-19 coronavirus infection and acute hypoxic respiratory failure ... |
Aetiology of neonatal conjunctivitis evaluated in a population‐based setting | AIM: Our aim was to study prospectively the aetiology of neonatal conjunctivitis in a population‐based setting. METHODS: Altogether 173 neonates with clinical conjunctivitis aged on average 20 (SD 10) days were recruited from child welfare clinics in Oulu, Finland, in 2010–2015. Conjunctival specimens were collected fr... |
Localisation and distribution of O-acetylated N-acetylneuraminic acids, the endogenous substrates of the hemagglutinin-esterases of murine coronaviruses, in mouse tissue | Infections by mouse hepatitis viruses result in disease of the liver, the gastrointestinal tract, respiratory tract, and the central nervous system. Coronaviruses related to mouse hepatitis virus express a hemagglutinin-esterase surface glycoprotein, which specifically hydrolyses either 5-N-acetyl-4-O-acetyl neuraminic... |
Both ADP-Ribosyl-Binding and Hydrolase Activities of the Alphavirus nsP3 Macrodomain Affect Neurovirulence in Mice | Macrodomain (MD), a highly conserved protein fold present in a subset of plus-strand RNA viruses, binds to and hydrolyzes ADP-ribose (ADPr) from ADP-ribosylated proteins. ADPr-binding by the alphavirus nonstructural protein 3 (nsP3) MD is necessary for the initiation of virus replication in neural cells, whereas hydrol... |
Are Surgeons in India prepared for COVID−19? | |
Viral Metagenomics Revealed Sendai Virus and Coronavirus Infection of Malayan Pangolins (Manis javanica) | Pangolins are endangered animals in urgent need of protection. Identifying and cataloguing the viruses carried by pangolins is a logical approach to evaluate the range of potential pathogens and help with conservation. This study provides insight into viral communities of Malayan Pangolins (Manis javanica) as well as t... |
Recombinant Chimeric Transmissible Gastroenteritis Virus (TGEV)—Porcine Epidemic Diarrhea Virus (PEDV) Virus Provides Protection against Virulent PEDV | Porcine epidemic diarrhea virus (PEDV) is an enteric coronavirus causing high morbidity and mortality in porcine herds worldwide. Although both inactivated and live attenuated vaccines have been extensively used, the emergence of highly virulent strains and the recurrent outbreaks even in vaccinated farms highlight the... |
Measures to Limit COVID-19 Outbreak Effects Among Military Personnel: Preliminary Data | INTRODUCTION: The COVID-19 outbreak posed a threat to the readiness of military forces as well as their ability to fulfill missions. Seeing that military forces have been encountering similar challenges, we found it eminent to share the Israeli Defense Force (IDF) Northern Command’s (NC) preliminary experience. MATERIA... |
Proposed Modifications in the 6-Minute Walk Test for Potential Application in Patients With Mild COVID-19: A Step to Optimize Triage Guidelines | Supplemental Digital Content is available in the text. |
The effects of COVID-19 pandemic on the provision of urgent surgery: a perspective from the USA | Corona virus pandemic has affected all the 50 states in the USA. States such as NY, CA and WA being the most affected. According to the Centers for Disease Control and Prevention (CDC) website, as of 28 March 2020, the total number of cases in the USA is over 103 300 and number of deaths to 1668. In the coming weeks, C... |
Impact of TGEV infection on the pig small intestine | BACKGROUND: Pig diarrhea causes high mortality and large economic losses in the swine industry. Transmissible gastroenteritis virus (TGEV) causes pig diarrhea, with 100% mortality in piglets less than 2 weeks old. No investigation has yet been made of the small intestine of piglets that survived infection by TGEV. METH... |
ESMO Management and treatment adapted recommendations in the COVID-19 era: Breast Cancer | The global preparedness and response to the rapid escalation to severe acute respiratory syndrome coronavirus (SARS-CoV)-2-related disease (COVID-19) to a pandemic proportion has demanded the formulation of a reliable, useful and evidence-based mechanism for health services prioritisation, to achieve the highest qualit... |
Passive Immunotherapy: Assessment of Convalescent Serum Against Ebola Virus Makona Infection in Nonhuman Primates | Background. Convalescent serum and blood were used to treat patients during outbreaks of Zaire ebolavirus (ZEBOV) infection in 1976 and 1995, with inconclusive results. During the recent 2013–2016 West African epidemic, serum/plasma from survivors of ZEBOV infection was used to treat patients in the affected countries ... |
Cardiac Valves: Another “Disaster-Hit Area” of COVID-19 Patients? | |
Whole-genome based Archaea phylogeny and taxonomy: A composition vector approach | The newly proposed alignment-free and parameter-free composition vector (CVtree) method has been successfully applied to infer phylogenetic relationship of viruses, chloroplasts, bacteria, and fungi from their whole-genome data. In this study we pay special attention to the phylogenetic positions of 56 Archaea genomes ... |
An APN-activated NIR photosensitizer for cancer photodynamic therapy and fluorescence imaging | Abstract Photodynamic therapy has been developed as a prospective cancer treatment in recent years. Nevertheless, conventional photosensitizers suffer from lacking recognition and specificity to tumors, which causing severe side effects to normal tissues, while the enzyme-activated photosensitizers are capable of solvi... |
Le diagnostic rapide des infections à virus respiratoire syncytial (RS) par le titrage des IgM sériques (immunofluorescence indirecte) | Summary In January 1981, during an outbreak of respiratory diseases in babies aged between 1 and 3 months, 9 patients with severe bronchiolitis were hospitalized in a Pediatric ward and 11 cases occurred as nosocomial infections. For direct rapid diagnosis, pharyngeal swabs and nasal aspirations were obtained from 10 o... |
Identification of the membrane protein of porcine epidemic diarrhea virus | Sequence information on the genome of porcine epidemic diarrhea virus (PEDV) has only recently been determined. In contrast, very little is known about the viral proteins. In the present report we have identified the membrane glycoprotein (M) of PEDV by use of rabbit anti-peptide sera and transient expression of the cl... |
Potentially preventable urinary tract infection in patients with type 2 diabetes – A hospital-based study | Abstract Aim To investigate the prevalence of urinary tract infections in hospitalized patients with type 2 diabetes mellitus and identify corresponding risk factors. Methods We conducted a cross-sectional study on 7.347 patients with type 2 diabetes mellitus as the principal diagnosis, using hospitalization discharge ... |
COVID‐19 and sports medicine research | |
Detection of adenoviruses in faeces and the confirmation of isolates by latex agglutination | Abstract An adenovirus (AV) group-specific latex agglutination test (LA) was assessed for its ability to detect AVs in faeces and to confirm the isolation of AVs in cell culture. It detected all of 62 strains belonging to subgenus F (AdF) but only 4 40 non-AdF serotypes. This is possibly due to the concentration of AdF... |
Modeling triple-diffusions of infectious diseases, information, and preventive behaviors through a metropolitan social network—An agent-based simulation | Abstract A typical epidemic often involves the transmission of a disease, the flow of information regarding the disease, and the spread of human preventive behaviors against the disease. These three processes diffuse simultaneously through human social networks, and interact with one another, forming negative and posit... |
Glucose signalling pathway controls the programmed ribosomal frameshift efficiency in retroviral‐like element Ty3 in Saccharomyces cerevisiae | Ty3 elements of S. cerevisiae contain two overlapping coding regions, GAG3 and POL3, which are functional homologues of retroviral gag and pol genes, respectively. Pol3 is translated as a Gag3‐Pol3 fusion protein dependent on a +1 programmed frameshift at a site with the overlap between the two genes. We show that the ... |
Self-assembled natural rubber/silica nanocomposites: Its preparation and characterization | Abstract A novel natural rubber/silica (NR/SiO2) nanocomposite is developed by combining self-assembly and latex-compounding techniques. The results show that the SiO2 nanoparticles are homogenously distributed throughout NR matrix as nano-clusters with an average size ranged from 60 to 150nm when the SiO2 loading is l... |
Mouse Hepatitis Virus Infection Upregulates Genes Involved in Innate Immune Responses | Neurotropic recombinant strain of Mouse Hepatitis Virus, RSA59, induces meningo-encephalitis, myelitis and demyelination following intracranial inoculation. RSA59 induced neuropathology is partially caused by activation of CNS resident microglia, as demonstrated by changes in cellular morphology and increased expressio... |
President’s Page: The Impact of the COVID-19 Pandemic on Cardiac CT | |
Get an exact diagnosis in hours | A device that can identify all bacteria, viruses and fungi known to cause disease in humans should make diagnosis less of a guessing game, helping to curb the problem of antibiotic resistance |
The porcine virome and xenotransplantation | The composition of the porcine virome includes viruses that infect pig cells, ancient virus-derived elements including endogenous retroviruses inserted in the pig chromosomes, and bacteriophages that infect a broad array of bacteria that inhabit pigs. Viruses infecting pigs, among them viruses also infecting human cell... |
Marked escalation in journal submissions during COVID19 pandemic | |
Including the public in pandemic planning: a deliberative approach | BACKGROUND: Against a background of pandemic threat posed by SARS and avian H5N1 influenza, this study used deliberative forums to elucidate informed community perspectives on aspects of pandemic planning. METHODS: Two deliberative forums were carried out with members of the South Australian community. The forums were ... |
The limits of global health diplomacy: Taiwan’s observer status at the world health assembly | In 2009, health authorities from Taiwan (under the name “Chinese Taipei”)(a) formally attended the 62(nd) World Health Assembly (WHA) of the World Health Organization as observers, marking the country’s participation for the first time since 1972. The long process of negotiating this breakthrough has been cited as an e... |
Rabbit Clinical Pathology | Abstract With rabbit patients, as in other species, analyzing blood and urine samples can be useful and informative, although interpretation of the results is sometimes challenging. This article summarizes the interpretation of laboratory results from rabbits. Hematological parameters can yield information about the re... |
Randomized, double‐blind, placebo‐controlled trial of interferon Alfa2a with and without amantadine as initial treatment for chronic hepatitis C | Although the antiviral effects of amantadine sulphate (1‐aminoadamantan sulphate) have not been characterized for the hepatitis C virus (HCV), previous pilot studies have suggested promising results in patients with chronic hepatitis C. The aim of the present study was to compare the efficacy, safety, and health‐relate... |
Serological Evidence of MERS-CoV Antibodies in Dromedary Camels (Camelus dromedaries) in Laikipia County, Kenya | Middle East respiratory syndrome coronavirus (MERS-CoV) is a recently identified virus causing severe viral respiratory illness in people. Little is known about the reservoir in the Horn of Africa. In Kenya, where no human MERS cases have been reported, our survey of 335 dromedary camels, representing nine herds in Lai... |
Airway permeability | |
The effect of travel restrictions on the spread of the 2019 novel coronavirus (COVID-19) outbreak | Motivated by the rapid spread of COVID-19 in Mainland China, we use a global metapopulation disease transmission model to project the impact of travel limitations on the national and international spread of the epidemic. The model is calibrated based on internationally reported cases, and shows that at the start of the... |
Preparations for the Safe Management of Severe Acute Respiratory Syndrome (SARS) Research Protocol Patients | Abstract ISSUE: The Warren G Magnuson Clinical Center (CC) strives to achieve a balance between its mission and worker and patient safety. PROJECT: As part of its mission as one of the government's primary research facilities, the CC must be able to address epidemiologically significant public health concerns as they a... |
Increased ACE2 Expression in the Bronchial Epithelium of COPD Patients who are Overweight | OBJECTIVE: Mortality from coronavirus disease 2019 (COVID‐19) is increased in COPD patients. Furthermore, higher body mass index (BMI) is related to severe disease. SARS‐CoV‐2 utilises angiotensin converting enzyme 2 (ACE2) to gain cellular entry. METHODS: We have investigated whether ACE2 bronchial epithelial expressi... |
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