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Risk Factors for Primary Middle East Respiratory Syndrome Coronavirus Infection in Camel Workers in Qatar During 2013–2014: A Case-Control Study | The transmission routes and risk factors for zoonotic Middle East respiratory syndrome coronavirus (MERS-CoV) infections are still unknown. We used the World Health Organization questionnaire for MERS-CoV case-control studies to assess risk factors for human MERS-CoV seropositivity at a farm complex in Qatar. Nine came... |
Application of refined management in prevention and control of the coronavirus disease 2019 epidemic in non-isolated areas of a general hospital | Abstract Objective This article summarizes the experience in the prevention and control of coronavirus disease 2019(COVID-19) epidemic in non-isolated areas in a general hospital. Methods Based on refined management theory, we professionally developed the standards for prevention and control of COVID-19 in non-isolated... |
Development of HPV(16,18,31,45) E5 and E7 peptides-based vaccines predicted by immunoinformatics tools | OBJECTIVES: Viral oncoproteins are ideal targets in therapeutic vaccines for functional inhibition of human papillomaviruses (HPVs). Herein, we designed the peptide constructs derived from E5 and E7 oncoproteins of high-risk HPV types 16, 18, 31 and 45 using the bioinformatics tools and investigated their potency in mi... |
How can we evaluate an interrelation of symptoms? | A pandemic of 2019 novel coronavirus (COVID-19) is an international problem and factors associated with increased risk of mortality have been reported. However, there exists limited statistical method to estimate a comprehensive risk for a case in which a patient has several characteristics and symptoms concurrently. W... |
Research on the urban resilience evaluation with hybrid multiple attribute TOPSIS method: an example in China | Cities are important barriers to protect people’s lives and property in the face of natural disasters, economic fluctuations and epidemic diseases. The evaluation of urban resilience is a hybrid multiple attribute group decision-making problem involving both crisp and fuzzy indicators. In order to evaluate the urban re... |
Human rhinovirus infections of the lower respiratory tract in hematopoietic stem cell transplant recipients | BACKGROUND: Human rhinoviruses (HRVs) are a common cause of upper respiratory infection (URI) in hematopoietic stem cell transplant (HSCT) recipients; yet, their role in lower respiratory illness is not well understood. METHODS: We performed a retrospective chart review of HSCT recipients with HRV infection from the ti... |
The renin–angiotensin–aldosterone system as a link between obesity and coronavirus disease 2019 severity | Coronavirus disease 2019 (COVID‐19), caused by the severe acute respiratory distress coronavirus 2 (SARS‐CoV2), is a rapidly evolving pandemic challenging the world and posing unprecedented public health issues. Current data show that COVID‐19 is associated with increased disease severity in individuals with obesity. O... |
The disguised pandemic: The importance of data normalization in COVID-19 web mapping | |
Clinical education of ethicists: the role of a clinical ethics fellowship | BACKGROUND: Although clinical ethicists are becoming more prevalent in healthcare settings, their required training and education have not been clearly delineated. Most agree that training and education are important, but their nature and delivery remain topics of debate. One option is through completion of a clinical ... |
A Bioethical Perspective for Navigating Moral Dilemmas Amidst the COVID-19 Pandemic | The Coronavirus disease 2019 pandemic has been an unprecedented challenge to healthcare systems and clinicians around the globe. As the virus has spread, critical questions arose about how to best deliver health care in emergency situations where material and personnel resources become scarce. Clinicians who excel at c... |
Changement de tropisme des coronavirus | Résumé Le tropisme d’un virus se définit comme l’ensemble des cellules cibles et permissives à ce virus. Le connaître permet de déterminer le ou les organes cibles, ainsi que la ou les espèces animales pouvant être infectées. Le changement de tropisme permet aux virus d’évoluer, notamment en leur permettant de franchir... |
Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: a current perspective | Owing to the efficacy in reducing pain and inflammation non-steroidal anti-inflammatory drugs (NSAIDs) are amongst the most popularly used medicines, confirming their position in the WHO’s Model List of Essential Medicines. With escalating musculoskeletal complications, as evident from 2016 Global Burden of Disease dat... |
Antigenic and biological comparisons of bovine coronaviruses derived from neonatal calf diarrhea and winter dysentery of adult cattle | The antigenic and biological properties of 6 strains of bovine coronavirus (BCV) derived from neonatal calf diarrhea (CD) and 8 strains of BCV from winter dysentery (WD) of adult cattle, propagated in HRT-18 cells, were compared to determine if CD and WD strains belong to distinct serotypes or subtypes of BCV. All stra... |
A practical approach for the management of obstetric and infertile women during the Phase Two of the Novel Coronavirus Disease 2019 (COVID ‐19) Pandemic | |
Infection prevention and control measures during COVID‐19 from medical physics perspective: A single institution experience from China | |
Outbreak detection model based on danger theory | Abstract In outbreak detection, one of the key issues is the need to deal with the weakness of early outbreak signals because this causes the detection model to have has less capability in terms of robustness when unseen outbreak patterns vary from those in the trained model. As a result, an imbalance between high dete... |
Challenges in early phase clinical trials for childhood cancer during the COVID-19 pandemic: a report from the new agents group of the Spanish Society of Paediatric Haematology and Oncology (SEHOP) | PURPOSE: The COVID-19 pandemic has forced healthcare stakeholders towards challenging decisions. We analyse the impact of the pandemic on the conduct of phase I–II trials for paediatric cancer during the first month of state of alarm in Spain. METHODS: A questionnaire was sent to all five ITCC-accredited Spanish Paedia... |
VADR: validation and annotation of virus sequence submissions to GenBank | BACKGROUND: GenBank contains over 3 million viral sequences. The National Center for Biotechnology Information (NCBI) previously made available a tool for validating and annotating influenza virus sequences that is used to check submissions to GenBank. Before this project, there was no analogous tool in use for non-inf... |
COVID-19 Cytokine Storm and Novel Truth | |
Einstellung von Patienten mit entzündlich-rheumatischen Erkrankungen zur immunsuppressiven Therapie im Rahmen der COVID-19 Pandemie – eine Situationsanalyse | The current COVID-19 pandemic inherits an unprecedented challenge for the treating rheumatologists. On the one hand, antirheumatic drugs can increase the risk of infection and potentially deteriorate the course of an infection. On the other hand, an active inflammatory rheumatic disease can also increase the risk for a... |
Enfermedad pulmonar obstructiva crónica e infección por SARS-CoV-2. ¿Qué sabemos hasta ahora? | |
Predictive Value of Respiratory Viral Detection in the Upper Respiratory Tract for Infection of the Lower Respiratory Tract With Hematopoietic Stem Cell Transplantation | BACKGROUND: Hematopoietic cell transplant (HCT) recipients are frequently infected with respiratory viruses (RVs) in the upper respiratory tract (URT), but the concordance between URT and lower respiratory tract (LRT) RV detection is not well characterized. METHODS: Hematopoietic cell transplant candidates and recipien... |
Acute Generalized Exanthematous Pustulosis with Erythema Multiforme‐Like lesions in a COVID‐19 woman | The antimalarials, Chloroquine and Hydroxychloroquine (HCQ), and the antivirals Lopinavir/Ritonavir have been recently recorded as having anti‐severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) effects.(1) In particular, regarding Italy, one of the countries most affected by the pandemic, the Italian Society ... |
Multisystem Inflammatory Syndrome in Children (MIS-C) with COVID-19: Insights from simultaneous familial Kawasaki Disease cases | Abstract Recently, an increasing number of patients of SARS-CoV-2 with syndrome which overlaps with Kawasaki Disease (KD) has been reported, supporting the idea that infection is one of triggers of KD. We summarized the reports of simultaneous familial KD cases for understanding etiopathogenesis of both KD and Multisys... |
Vaccine‐Associated Immune‐Mediated Hemolytic Anemia in the Dog | Vaccination has been incriminated as a trigger of immune‐mediated hemolytic anemia (IMHA) in dogs and in people, but evidence to support this association is lacking. In a controlled retrospective study, idiopathic IMHA was identified in 58 dogs over a 27–month period. When compared with a randomly selected control grou... |
Thermal cures and COVID-19 | |
Estimating a breakpoint in the spread pattern of COVID-19 in South Korea | OBJECTIVES: Amid the global COVID-19 crisis, South Korea has been touted for successfully preventing the spread of the infectious disease, which may be due to the aggressive implementation of preventive policies. We evaluated the spread pattern of COVID-19 in South Korea considering the potential impact of policy inter... |
The impact of macroeconomic and non-macroeconomic forces on hotel stock returns | Abstract This study aimed to examine the relationship between macroeconomic and non-macroeconomic variables and hotel stock returns using hotel companies listed on the Taiwan Stock Exchange. The regression analysis indicated that among the macroeconomic variables (i.e., money supply, the growth rate of industrial produ... |
An NTP-binding motif is the most conserved sequence in a highly diverged monophyletic group of proteins involved in positive strand RNA viral replication | NTP-motif, a consensus sequence previously shown to be characteristic of numerous NTP-utilizing enzymes, was identified in nonstructural proteins of several groups of positive-strand RNA viruses. These groups include picorna-, alpha-, and coronaviruses infecting animals and como-, poty-, tobamo-, tricorna-, hordei-, an... |
Virtual drug testing: redefining sample collection in a global pandemic | |
Occupational Health Science in the Time of COVID-19: Now more than Ever | Workers bear a heavy share of the burden of how countries contend with COVID-19; they face numerous serious threats to their occupational health ranging from those associated with direct exposure to the virus to those reflecting the conflicts between work and family demands. Ten experts were invited to comment on occup... |
Report of the fifth symposium on emerging viral diseases | |
Preventive behaviors, beliefs, and anxieties in relation to the swine flu outbreak among college students aged 18–24 years | AIM: The objective of this study was to assess beliefs, misconception, and anxiety in relation to swine flu outbreak and whether perception of the outbreak predicted changes in behavior. SUBJECT AND METHODS: In November 2009, we conducted an Internet-based cross-sectional survey of college students aged 18–24 years in ... |
Time to restart: A comparative compilation of triage recommendations in dentistry during the Covid −19 pandemic | BACKGROUND: The novel coronavirus (COVID-19) pandemic has become a enormous challenge for the health care facilitators. It has significantly affected the dental professionals in their clinical practices, hospitals and even dental schools. Due to the risk of cross – infection involved within in the dental setting, the d... |
The Economic and Public Health Imperatives Around Making Potential Coronavirus Disease–2019 Treatments Available and Affordable | ▪▪▪ |
First assessment of microbial diversity in faecal microflora of Eurasian otter (Lutra lutra Linnaeus, 1758) in Portugal | The Eurasian otter (Lutra lutra Linnaeus, 1758), a predator from the Order Carnivora, Family Mustelidae, evolved the ability to swim and forage in water, being an important element of biodiversity. Otters are widely spread through Portugal, and scats have been extensively used in ecology studies; however, valid informa... |
Comprehensive analysis of the codon usage patterns in the envelope glycoprotein E2 gene of the classical swine fever virus | The classical swine fever virus (CSFV), circulating worldwide, is a highly contagious virus. Since the emergence of CSFV, it has caused great economic loss in swine industry. The envelope glycoprotein E2 gene of the CSFV is an immunoprotective antigen that induces the immune system to produce neutralizing antibodies. T... |
Antiviral activity of Aloe hijazensis against some haemagglutinating viruses infection and its phytoconstituents | Evaluation of the antiviral activities of flowers, flower-peduncles, leaves, and roots of Aloe hijazensis against haemagglutinating viruses of avian paramyxovirus type-1 (APMV-1), avian influenza virus type A (AI-H5N1), Newcastle disease virus (NDV), and egg-drop syndrome virus (EDSV) in specific pathogen free (SPF) ch... |
Functional characteristics of patients with SARS-CoV-2 pneumonia at 30 days post infection | More than half of patients with Covid-19 pneumonia exhibit abnormal lung function 30 days after symptoms onset, without clear relationship with pneumonia extent on chest-CT. This pleads for systematic and long-term follow-up of patients with Covid. |
COVID-19 and forced alcohol abstinence in India: The dilemmas around ethics and rights | In response to the COVID-19 pandemic, as with other countries across the world, the Central and State Governments of India initiated several measures to slow down the spread of the virus and to ‘flatten the curve’. One such measure was a ‘total lockdown’ for several weeks across the country. A complex and unexpected ou... |
Individual sequences in large sets of gene sequences may be distinguished efficiently by combinations of shared sub-sequences | BACKGROUND: Most current DNA diagnostic tests for identifying organisms use specific oligonucleotide probes that are complementary in sequence to, and hence only hybridise with the DNA of one target species. By contrast, in traditional taxonomy, specimens are usually identified by 'dichotomous keys' that use combinatio... |
Serological Diagnosis of Flavivirus-Associated Human Infections | Arthropod-borne viruses (arboviruses) belonging to the Flavivirus genus of the Flaviviridae family, are a major public health threat in tropical and subtropical regions, and have recently become a medical concern in temperate zones. Most flaviviruses are classified as zoonotic viruses. Human flavivirus infections can b... |
Gilles de la Tourette Syndrome: advice in the times of COVID-19 | The novel coronavirus disease (COVID-19) was identified as the cause of an outbreak of respiratory disease in China at the end of 2019. It then spread with enormous rapidity and by mid-March 2020 was declared a world pandemic. Gilles de la Tourette Syndrome (GTS) is a childhood-onset neurodevelopmental disorder with a ... |
Post-SARS tourist arrival recovery patterns: An analysis based on a catastrophe theory | In 2003, the Severe Acute Respiratory Syndrome (SARS) ravaged many Asian countries. The outbreak of SARS caused a crisis in the tourism industry in many parts of Asia in that year. The purpose of this study is to examine and to compare the post-SARS recovery patterns of inbound arrivals from Japan, Hong Kong and USA in... |
Genetic characterization of porcine epidemic diarrhea virus in Korea from 1998 to 2013 | The number of porcine epidemic diarrhea (PED) cases has increased over the past 20 years in Korea, with a major outbreak in 2013. A total of 27 Korean strains from 1998 to 2013 were analyzed (excluding the noncoding regions) and divided into two groups for comparison of the spike (S), ORF3, envelope (E), membrane (M), ... |
Serious Adverse Events Associated With Hydroxychloroquine Amidst COVID-19 Pandemic: Case Series and Literature Review | COVID-19 represents a global health crisis. Several studies are evaluating potential therapies including hydroxychloroquine (HCQ) which is given to patients based on limited observational evidence. However, it can cause serious adverse events. Moreover, recent studies showed no benefits due to HCQ. We present two COVID... |
Characterization of peritoneal cells from cats with experimentally-induced feline infectious peritonitis (FIP) using RNA-seq | Laboratory cats were infected with a serotype I cat-passaged field strain of FIP virus (FIPV) and peritoneal cells harvested 2–3 weeks later at onset of lymphopenia, fever and serositis. Comparison peritoneal cells were collected from four healthy laboratory cats by peritoneal lavage and macrophages predominated in bot... |
Characterization of the Filovirus-Resistant Cell Line SH-SY5Y Reveals Redundant Role of Cell Surface Entry Factors | Filoviruses infect a wide range of cell types with the exception of lymphocytes. The intracellular proteins cathepsin B and L, two-pore channel 1 and 2, and bona fide receptor Niemann–Pick Disease C1 (NPC1) are essential for the endosomal phase of cell entry. However, earlier steps of filoviral infection remain poorly ... |
Current and Emerging Therapeutics for Neuromyelitis Optica Spectrum Disorder: Relevance to the COVID-19 Pandemic | Neuromyelitis optica spectrum disorder (NMOSD) can lead to immobility and bulbar weakness. This, in addition to the older age of onset and the higher rate of hospitalization compared to multiple sclerosis, makes this patient group a potential target for complicated COVID-19 infection. Moreover, many of the commonly use... |
Establishment and Application of a Universal Coronavirus Screening Method Using MALDI-TOF Mass Spectrometry | There are four human coronaviruses (HCoVs), distributed worldwide, that are associated with a range of respiratory symptoms. The discovery of severe acute respiratory syndrome (SARS)-CoV and Middle East respiratory syndrome (MERS)-CoV shows that HCoVs pose a significant threat to human health. Our work aims to develop ... |
Three-Dimensional Architecture and Biogenesis of Membrane Structures Associated with Plant Virus Replication | Positive-sense (+) RNA viruses represent the most abundant group of viruses and are dependent on the host cell machinery to replicate. One remarkable feature that occurs after (+) RNA virus entry into cells is the remodeling of host endomembranes, leading to the formation of viral replication factories. Recently, rapid... |
Development and characterization of serotype-specific monoclonal antibodies against the dengue virus-4 (DENV-4) non-structural protein (NS1) | BACKGROUND: Dengue, caused by one of the four serologically distinct dengue viruses (DENV-1 to − 4), is a mosquito-borne disease of serious global health significance. Reliable and cost-effective diagnostic tests, along with effective vaccines and vector-control strategies, are highly required to reduce dengue morbidit... |
Chapter 3 Early Stages of Infection After Pathogen Entry | In this chapter, we describe the early stages of the pathogenic cycle involving entry into the host. For example, some bacteria may enter into epithelial cells, proliferate and then spread at the epithelial surface before being transmitted to another host. Some pathogens then migrate past the epithelial layer to deeper... |
Vesicular Stomatitis Virus-Based Ebola Vaccine Is Well-Tolerated and Protects Immunocompromised Nonhuman Primates | Ebola virus (EBOV) is a significant human pathogen that presents a public health concern as an emerging/re-emerging virus and as a potential biological weapon. Substantial progress has been made over the last decade in developing candidate preventive vaccines that can protect nonhuman primates against EBOV. Among these... |
Coronavirus disease (COVID-19) and fertility: viral host entry protein expression in male and female reproductive tissues | Abstract Objective To identify cell types in the male and female reproductive systems at risk of SARS-CoV-2 infection due to expression of host genes and proteins used by the virus for cell entry. Design Descriptive analysis of transcriptomic and proteomic data. Setting Academic research department and clinical diagnos... |
Hepatitis E Virus Replication | Hepatitis E virus (HEV) is a small quasi-enveloped, (+)-sense, single-stranded RNA virus belonging to the Hepeviridae family. There are at least 20 million HEV infections annually and 60,000 HEV-related deaths worldwide. HEV can cause up to 30% mortality in pregnant women and progress to liver cirrhosis in immunocompro... |
Pathogen seasonality and links with weather in England and Wales: a big data time series analysis | BACKGROUND: Many infectious diseases of public health importance display annual seasonal patterns in their incidence. We aimed to systematically document the seasonality of several human infectious disease pathogens in England and Wales, highlighting those organisms that appear weather-sensitive and therefore may be in... |
Modeling monthly flows of global air travel passengers: An open-access data resource | Abstract The global flow of air travel passengers varies over time and space, but analyses of these dynamics and their integration into applications in the fields of economics, epidemiology and migration, for example, have been constrained by a lack of data, given that air passenger flow data are often difficult and ex... |
COVID-19 and vitamin D—Is there a link and an opportunity for intervention? | |
CANCER IN THE TIME OF COVID: Expert opinion on how to adapt current practice | The susceptibility of cancer patients to adverse outcome of viral infections is well known from past experiences, e.g. Influenza increasing the risk of hospital admission with respiratory distress four times, and the risk of death ten times, compared to patients without cancer [1]. |
IFN-β-inducing, unusual viral RNA species produced by paramyxovirus infection accumulated into distinct cytoplasmic structures in an RNA-type-dependent manner | The interferon (IFN) system is one of the most important defensive responses of mammals against viruses, and is rapidly evoked when the pathogen-associated molecular patterns (PAMPs) of viruses are sensed. Non-self, virus-derived RNA species have been identified as the PAMPs of RNA viruses. In the present study, we com... |
Perceived risk, anxiety, and behavioural responses of the general public during the early phase of the Influenza A (H1N1) pandemic in the Netherlands: results of three consecutive online surveys | BACKGROUND: Research into risk perception and behavioural responses in case of emerging infectious diseases is still relatively new. The aim of this study was to examine perceptions and behaviours of the general public during the early phase of the Influenza A (H1N1) pandemic in the Netherlands. METHODS: Two cross-sect... |
Throat and nasal swabs for molecular detection of respiratory viruses in acute pharyngitis | BACKGROUND: Detection of specific respiratory viruses is important for surveillance programs, where nasopharyngeal or nasal swabs have traditionally been used. Our objective was to determine whether sampling with a throat swab provides incremental benefit—when used in conjunction with a nasal swab—to detect respiratory... |
COVID‐19 in dimethyl fumarate‐treated patients with multiple sclerosis | |
EVOLUTION AND MEDICINE IN UNDERGRADUATE EDUCATION: A PRESCRIPTION FOR ALL BIOLOGY STUDENTS | The interface between evolutionary biology and the biomedical sciences promises to advance understanding of the origins of genetic and infectious diseases in humans, potentially leading to improved medical diagnostics, therapies, and public health practices. The biomedical sciences also provide unparalleled examples fo... |
Autophagy induced by bovine viral diarrhea virus infection counteracts apoptosis and innate immune activation | Bovine viral diarrhea virus (BVDV) is an important pathogen of cattle that plays a complex role in disease. There are two biotypes of BVDV: non-cytopathic (NCP) and cytopathic (CP). One strategy that has been used to treat or prevent virus-associated diseases is the modulation of autophagy, which is used by the innate ... |
Inhibitory effect of anti-aminopeptidase N/CD13 antibodies on fibroblast migration | Aminopeptidase N (APN)/CD13 is a widely expressed transmembrane ectoenzyme and has been implicated in a myriad of physiological processes that are specific to cell type and tissue origin, including cancer cell metastasis, angiogenesis, cholesterol uptake, apoptosis, and cell migration. Skin cells, in particular fibrobl... |
When do you say it's SARS‐CoV‐2‐associated diarrhea? | |
Could patients taking isotretinoin therapy be immune against SARS‐CoV‐2? | |
Recent advances in influenza vaccines | Seasonal influenza remains a major public health problem, responsible for hundreds of thousands of deaths every year, mostly of elderly people. Despite the wide availability of vaccines, there are multiple problems decreasing the effectiveness of vaccination programs. These include viral variability and hence the requi... |
Early Self‐Proning in Awake, Non‐intubated Patients in the Emergency Department: A Single ED’s Experience During the COVID‐19 Pandemic | OBJECTIVE: Prolonged and unaddressed hypoxia can lead to poor patient outcomes. Proning has become a standard treatment in the management of patients with ARDS who have difficulty achieving adequate oxygen saturation. The purpose of this study was to describe the use of early proning of awake, non‐intubated patients in... |
Predictors of symptoms of posttraumatic stress in Chinese university students during the 2009 H1N1 influenza pandemic | BACKGROUND: The university environment poses a high risk of spreading infectious diseases, particularly the 2009 pandemic influenza H1N1, as it is a mass gathering place for youth. This study aimed to evaluate the predictors of stress symptoms among Chinese university students during the 2009 H1N1 influenza pandemic. M... |
Efficiency of Airborne Sample Analysis Platform (ASAP) bioaerosol sampler for pathogen detection | The threat of bioterrorism and pandemics has highlighted the urgency for rapid and reliable bioaerosol detection in different environments. Safeguarding against such threats requires continuous sampling of the ambient air for pathogen detection. In this study we investigated the efficacy of the Airborne Sample Analysis... |
RETRACTED ARTICLE: Interferon-mediated antiviral activities of Angelica tenuissima Nakai and its active components | Angelica tenuissima Nakai is a widely used commodity in traditional medicine. Nevertheless, no study has been conducted on the antiviral and immune-modulatory properties of an aqueous extract of Angelica tenuissima Nakai. In the present study, we evaluated the antiviral activities and the mechanism of action of an aque... |
Advances Towards Painless Vaccination and Newer Modes of Vaccine Delivery | Vaccines have been successful in reducing the mortality and morbidity, but most of them are delivered by intramuscular or intravenous route. They are associated with pain to the baby and bring lot of anxiety for the parents. There has been a marked increase in the number of injections required in first two years of lif... |
MERS-CoV geography and ecology in the Middle East: analyses of reported camel exposures and a preliminary risk map | BACKGROUND: Middle Eastern respiratory syndrome coronavirus (MERS-CoV) has spread rapidly across much of the Middle East, but no quantitative mapping of transmission risk has been developed to date. Moreover, details of the transmission cycle of the virus remain unclear, particularly regarding the role of camels as a r... |
The Globalization of Healthcare: Implications of Medical Tourism for the Infectious Disease Clinician | Travel abroad for healthcare has increased rapidly; interventions include organ transplant; cardiac surgery; reproductive care; and joint, cosmetic, and dental procedures. Individuals who receive medical care abroad are a vulnerable, sentinel population, who sample the local environment and can carry home unusual and r... |
Fulminant Necrotizing Fasciitis and Nonsteroidal Anti-Inflammatory Drugs | |
Nocardia polymerase chain reaction (PCR)-based assay performed on bronchoalveolar lavage fluid after lung transplantation: A prospective pilot study | BACKGROUND: Transplant recipients are at risk of pulmonary nocardiosis, a life-threatening opportunistic infection caused by Nocardia species. Given the limitations of conventional diagnostic techniques (i.e., microscopy and culture), a polymerase chain reaction (PCR)-based assay was developed to detect Nocardia spp. o... |
Functional movement disorders in a patient with COVID-19 | The infectious diseases (ID) specialty continues to be in crisis due to a lack of interest by residents in the recruitment pool It is possible that enhancing and innovating how microbiology is taught in medical school could increase the interest in ID We need to improve teaching of preclinical medical microbiology and ... |
Caution and clarity required in the use of chloroquine for COVID-19 | |
African Primates: Likely Victims, Not Reservoirs, of Ebolaviruses | |
Investigation into the Role of Potentially Contaminated Feed as a Source of the First-Detected Outbreaks of Porcine Epidemic Diarrhea in Canada | SUMMARY: In January 2014, approximately 9 months following the initial detection of porcine epidemic diarrhea (PED) in the USA, the first case of PED was confirmed in a swine herd in south-western Ontario. A follow-up epidemiological investigation carried out on the initial and 10 subsequent Ontario PED cases pointed t... |
Nasal swab bacteriology by PCR during the first 24‐months of life: A prospective birth cohort study | BACKGROUND: Most respiratory bacterial carriage studies in children are based on cross‐sectional samples or longitudinal studies with infrequent sampling points. The prospective Observational Research in Childhood Infectious Diseases birth cohort study intensively evaluated the community‐based epidemiology of respirato... |
COVID-19 con afectación pulmonar. Una enfermedad autoinmune de causa conocida | |
COVID-19 Outbreak and Inflammatory Bowel Disease Management: A Questionnaire Survey From Realistic Practice | |
A Compact Immunoassay Platform Based on a Multicapillary Glass Plate | A highly sensitive, rapid immunoassay performed in the multi-channels of a micro-well array consisting of a multicapillary glass plate (MCP) and a polydimethylsiloxane (PDMS) slide is described. The micro-dimensions and large surface area of the MCP permitted the diffusion distance to be decreased and the reaction effi... |
Strengths, Weaknesses, Opportunities and Threats (SWOT) Analysis of China’s Prevention and Control Strategy for the COVID-19 Epidemic | This study used the Strengths (S), Weaknesses (W), Opportunities (O) and Threats (T) (SWOT) analysis method, drawing on our experience of the response to the 2003 SARS epidemic, the 2019 China Health Statistics Yearbook data, and changes in China’s policy environment for the pneumonia epidemic response relating to the ... |
Dengue virus infection induces autophagy: an in vivo study | BACKGROUND: We and others have reported that autophagy is induced by dengue viruses (DVs) in various cell lines, and that it plays a supportive role in DV replication. This study intended to clarify whether DV infection could induce autophagy in vivo. Furthermore, the effect of DV induced autophagy on viral replication... |
The effects of COVID-19 induced lockdown measures on maritime settings of a coastal region | Abstract The spread of coronavirus (COVID-19) caused an unprecedented implementation of lockdown measures across world's nations. Veneto Region, located in the North-Eastern Italy was one of the first maritime regions in Italy and Europe subjected to progressive lockdown restrictions. We systematically analyse the effe... |
Complete Genome Sequences of Two Genetically Distinct Variants of Porcine Epidemic Diarrhea Virus in the Eastern Region of Thailand | Porcine epidemic diarrhea virus (PEDV) has continued to cause sporadic outbreaks in Thailand since 2007. Previously, PEDV in Thailand was a new variant containing an insertion and deletion in the spike gene. Herein, full-length genome sequences are reported for two variants of PEDV isolates from pigs displaying diarrhe... |
Editorial note for manuscripts from the Second International Congress of the Asia Pacific Society of Infection Control (Singapore, March 14-17, 2004) submitted for publication in the American Journal of Infection Control | |
In vitro and in vivo evaluation of small interference RNA‐mediated gynaecophoral canal protein silencing in Schistosoma japonicum | BACKGROUND: Schistosomiasis causes liver and intestinal damage and can be very debilitating. The pairing of a male worm with a female worm residing in the gynaecophoral canal of male plays a critical role in the development of female parasite. Because the male specific gynaecophoral canal protein of Schistosoma japonic... |
Viroporins: structure and biological functions | Viroporins are small, hydrophobic proteins that are encoded by a wide range of clinically relevant animal viruses. When these proteins oligomerize in host cell membranes, they form hydrophilic pores that disrupt a number of physiological properties of the cell. Viroporins are crucial for viral pathogenicity owing to th... |
Evaluation of Low versus High Volume per Minute Displacement CO(2) Methods of Euthanasia in the Induction and Duration of Panic-Associated Behavior and Physiology | SIMPLE SUMMARY: Current recommendations for the use of CO(2) as a euthanasia agent for rats require the use of gradual fill methods in order to render the animal insensible prior to their experience of pain. However, there is concern that the use of these gradual fill methods may increase the distress experienced by th... |
Sensitive Diagnostics Confirm That Influenza C is an Uncommon Cause of Medically Attended Respiratory Illness in Adults | Among 4200 adults who presented with acute respiratory symptoms at a variety of medical practice settings (November 2006 through May 2012), only 13 (0.3%) nasal/throat swabs were positive for influenza C. Influenza C was rarely associated with medical care visits in adults. |
Relationships between A(H1N1)pdm09 influenza infection and infections with other respiratory viruses | BACKGROUND: A(H1N1)pdm09, a new influenza pandemic virus emerged in 2009. The A(H1N1)pdm09 infection had several unique characteristics which included rapid transmissibility and high morbidity in obese individuals, pregnant women and individuals suffering from chronic diseases. OBJECTIVES: To study the relationships be... |
ONLINE FORECASTING OF COVID-19 CASES IN NIGERIA USING LIMITED DATA | Abstract The novel Coronavirus disease (COVID-19) was first identified in Wuhan, China in December 2019 but later spread to other parts of the world. The disease as at the point of writing this paper has been declared a pandemic by the World Health Organization (WHO). The application of mathematical models, artificial ... |
Proposal for Coronavirus Disease 2019 Management | SETTING: The coronavirus disease 2019 pandemic has raised fear throughout the nation. Current news and social media predictions of ventilator, medication, and personnel shortages are rampant. PATIENTS: Patients with coronavirus disease 2019 are presenting with early respiratory distress and hypoxemia, but not hypercapn... |
Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform | Reverse genetics has been an indispensable tool revolutionising our insights into viral pathogenesis and vaccine development. Large RNA virus genomes, such as from Coronaviruses, are cumbersome to clone and to manipulate in E. coli hosts due to size and occasional instability1-3. Therefore, an alternative rapid and rob... |
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