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PMID:19785 | Early visual experience, learning, and neurochemical plasticity in the rat and the chick. | Rats reared in the dark to 50 days show morphological and biochemical changes in the visual pathway. Light exposure results in elevated incorporation into protein in visual cortex, lateral geniculate and retina. Much of the visual cortex elevation is in a rapidly labelling, rapidly transported neuronal particulate prot... | Early visual experience, learning, and neurochemical plasticity in the rat and the chick. Rats reared in the dark to 50 days show morphological and biochemical changes in the visual pathway. Light exposure results in elevated incorporation into protein in visual cortex, lateral geniculate and retina. Much of the visual... | [
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PMID:19786 | Plasticity in the adult vestibulo-ocular reflex arc. | Human subjects with maintained reversal of their horizontal field of vision exhibit very substantial adaptive changes in their 'horizontal' vestibulo-ocular reflex (v.o.r.). Short durations (8 min) of vision reversal during natural head movement led to 20% v.o.r. attenuation while long periods (4 weeks) eventually led ... | Plasticity in the adult vestibulo-ocular reflex arc. Human subjects with maintained reversal of their horizontal field of vision exhibit very substantial adaptive changes in their 'horizontal' vestibulo-ocular reflex (v.o.r.). Short durations (8 min) of vision reversal during natural head movement led to 20% v.o.r. att... | [
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PMID:19787 | Electrophysiological experiments on the mechanism and accuracy of neuromuscular specificity in the axolotl. | The supracoracoideus muscle of the axolotl shoulder girdle is innervated by two nerves, the supracoracoideus nerve (SC) supplying most of the muscle and the posterior supracoracoideus (PSC) supplying the posterior corner. All the muscle fibres are multiply innervated and at the border between the two innervations many ... | Electrophysiological experiments on the mechanism and accuracy of neuromuscular specificity in the axolotl. The supracoracoideus muscle of the axolotl shoulder girdle is innervated by two nerves, the supracoracoideus nerve (SC) supplying most of the muscle and the posterior supracoracoideus (PSC) supplying the posterio... | [
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PMID:19789 | The presence of ineffective synapses and the circumstances which unmask them. | In this paper, we shall show that there are substantial numbers of nerve terminals which are normally ineffective. In the intact animal, occasional signs of the postsynaptic effectiveness of these fibres can be seen under conditions of optimal spatial summation or increased excitability or decreased inhibition. If the ... | The presence of ineffective synapses and the circumstances which unmask them. In this paper, we shall show that there are substantial numbers of nerve terminals which are normally ineffective. In the intact animal, occasional signs of the postsynaptic effectiveness of these fibres can be seen under conditions of optima... | [
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PMID:19801 | Pharmacokinetics of N-desmethyldiazepam in healthy volunteers after single daily doses of dipotassium chlorazepate. | Dipotassium chlorazepate was administered to 12 healthy volunteers (8 males and 4 females), aged 22-38 years, as a single daily dose of 20 mg for 14 days. Plasma concentrations of N-desmethyldiazepam were monitored with a gas-chromatographic method during the medication period and for 5 days after withdrawal of the dru... | Pharmacokinetics of N-desmethyldiazepam in healthy volunteers after single daily doses of dipotassium chlorazepate. Dipotassium chlorazepate was administered to 12 healthy volunteers (8 males and 4 females), aged 22-38 years, as a single daily dose of 20 mg for 14 days. Plasma concentrations of N-desmethyldiazepam were... | [
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PMID:19802 | Morphine action in grouped and isolated rats and mice. | The present study determines the analgesic effects of morphine in grouped and isolated rats and mice. Isolated animals developed altered behavioral patterns, including mouse-killing in rats and mutual aggressiveness in mice. The analgesic effect of morphine was tested by tail compression in rats and by the hot plate fo... | Morphine action in grouped and isolated rats and mice. The present study determines the analgesic effects of morphine in grouped and isolated rats and mice. Isolated animals developed altered behavioral patterns, including mouse-killing in rats and mutual aggressiveness in mice. The analgesic effect of morphine was tes... | [
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PMID:19803 | Comparison of thyrotropin-releasing hormone with melanocyte-stimulating-hormone-release-inhibiting factor as pentobarbital antagonists in monkeys. | Thyrotropin-releasing hormone (TRH), 0.1 mg/kg, i.m., significantly counteracted pentobarbital narcosis in six monkeys, but melanocyte-stimulating-hormone-release-inhibiting factor (MIF), 0.1 mg/kg i.m., did not. Earlier dose-response studies in unanesthetized monkeys had shown that this dose of MIF stimulated motor ac... | Comparison of thyrotropin-releasing hormone with melanocyte-stimulating-hormone-release-inhibiting factor as pentobarbital antagonists in monkeys. Thyrotropin-releasing hormone (TRH), 0.1 mg/kg, i.m., significantly counteracted pentobarbital narcosis in six monkeys, but melanocyte-stimulating-hormone-release-inhibiting... | [
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PMID:19804 | Dose- and time-dependent effects of narcotic analgesics on intracranial self-stimulation in the rat. | Rats were trained to bar-press in order to obtain electrical stimulation of the medial forebrain bundle through chronically implanted electrodes. Dose-response and time-effect curves were determined for morphine (1.0-30 mg/kg), levorphanol (0.1 to 3.0 mg/kg), methadone (0.1-3.0 mg/kg), meperidine (1.0-30 mg/kg), oxymor... | Dose- and time-dependent effects of narcotic analgesics on intracranial self-stimulation in the rat. Rats were trained to bar-press in order to obtain electrical stimulation of the medial forebrain bundle through chronically implanted electrodes. Dose-response and time-effect curves were determined for morphine (1.0-30... | [
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PMID:19805 | Influence of the suspension of continued treatment with flurazepam and amobarbital on two discrimination learning schedules. | The authors have studied the effect of the suspension of chronic treatment with flurazepam and amobarbital on the operant behavior of rats that for the first time were in the presence of two fixed-interval discrimination schedules. With the sound discrimination schedule, the responses emitted by the treated animals had... | Influence of the suspension of continued treatment with flurazepam and amobarbital on two discrimination learning schedules. The authors have studied the effect of the suspension of chronic treatment with flurazepam and amobarbital on the operant behavior of rats that for the first time were in the presence of two fixe... | [
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PMID:19806 | Blockade of intracranial self-stimulation by antipsychotic drugs: failure to correlate with central alpha-noradrenergic blockade. | The involvement of central alpha-noradrenergic receptors in intracranial self-stimulation (ICSS) was studied. Dose-response curves were established for the blockade of ICSS by the antipsychotic drugs chlorpromazine, thioridazine, clozapine, and pimozide and the alpha-antagonist phenoxybenzamine. Antagonism of the facil... | Blockade of intracranial self-stimulation by antipsychotic drugs: failure to correlate with central alpha-noradrenergic blockade. The involvement of central alpha-noradrenergic receptors in intracranial self-stimulation (ICSS) was studied. Dose-response curves were established for the blockade of ICSS by the antipsycho... | [
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PMID:19807 | Negative naloxone effects in schizophrenic patients. | On the basis of the hypothesis that the opiate-like neuropeptides, such as beta-endorphin, may be involved in the etiology of schizophrenic symptoms, naloxone 1,2 mg and placebo were administered intravenously to 8 schizophrenic patients, using a double-blind, crossover design. Naloxone was not found to be different fr... | Negative naloxone effects in schizophrenic patients. On the basis of the hypothesis that the opiate-like neuropeptides, such as beta-endorphin, may be involved in the etiology of schizophrenic symptoms, naloxone 1,2 mg and placebo were administered intravenously to 8 schizophrenic patients, using a double-blind, crosso... | [
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PMID:19810 | Effects of chronic hydrochloric and lactic acid administrations on food intake, blood acid-base balance and bone composition of the rat. | In experiment 1, weanling rats were given, for 7 weeks, a commercial rat diet supplemented with hydrochloric acid at levels up to 560 mmol.kg-1 dry matter. The supplement increased water intake but did not significantly affect food intake, live-weight gain, blood haemoglobin and haematocrit values or acid-base balance.... | Effects of chronic hydrochloric and lactic acid administrations on food intake, blood acid-base balance and bone composition of the rat. In experiment 1, weanling rats were given, for 7 weeks, a commercial rat diet supplemented with hydrochloric acid at levels up to 560 mmol.kg-1 dry matter. The supplement increased wa... | [
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PMID:19811 | The effect of fatigue on resident performance. | Fourteen rested and fatigued residents read a set of 25 test radiographs on two separate occasions approximately one month apart. The radiographs were made with partial chest phantom using pulmonary nodules as test objects. Seven rested and 7 fatigued residents read the radiographs, and a month later the order of fatig... | The effect of fatigue on resident performance. Fourteen rested and fatigued residents read a set of 25 test radiographs on two separate occasions approximately one month apart. The radiographs were made with partial chest phantom using pulmonary nodules as test objects. Seven rested and 7 fatigued residents read the ra... | [
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PMID:19812 | Prostaglandin E1 modifies nerve conduction and interferes with local anaesthetic action. | Prostaglandin E1 (PGE1) altered both the amplitude and conduction velocity of the compound action potential in frog sciatic nerve. Concentrations up to 1 ng/ml increased both amplitude and conduction velocity but at higher concentrations both effects were reversed. Procaine, chloroquine, indomethacin and SC19220 all re... | Prostaglandin E1 modifies nerve conduction and interferes with local anaesthetic action. Prostaglandin E1 (PGE1) altered both the amplitude and conduction velocity of the compound action potential in frog sciatic nerve. Concentrations up to 1 ng/ml increased both amplitude and conduction velocity but at higher concentr... | [
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PMID:19813 | On the structure of slow reacting substance of anaphylaxis: evidence of biosynthesis from arachidonic acid. | The mononuclear cells in peritoneal washings from normal rats can be induced to produce large amounts of slow reacting substance of anaphylaxis by incubation with 10 mM cysteine in the presence of the calcium ionophore A-23187. This production of slow reacting substance could be inhibited by the addition of non-steroid... | On the structure of slow reacting substance of anaphylaxis: evidence of biosynthesis from arachidonic acid. The mononuclear cells in peritoneal washings from normal rats can be induced to produce large amounts of slow reacting substance of anaphylaxis by incubation with 10 mM cysteine in the presence of the calcium ion... | [
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PMID:19814 | The TcO4-binding to human serum albumin --the stoichiometry and characteristics of the binding equilibrium. | The stoichiometry and the characteristics of the TcO4-binding equilibrium to human serum albumin were investigated by the use of 99TcO4-. Based on the Scatchard plots, the number of binding sites and the association constants were obtained at pH 7.38,6.04, 5.10, 4.18, 2.80 and 0.65, respectively. From the parameters at... | The TcO4-binding to human serum albumin --the stoichiometry and characteristics of the binding equilibrium. The stoichiometry and the characteristics of the TcO4-binding equilibrium to human serum albumin were investigated by the use of 99TcO4-. Based on the Scatchard plots, the number of binding sites and the associat... | [
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PMID:19817 | [Effect of methionine sulfone on the growth of Citrobacter intermedius C3 (author's transl)]. | Specific activity of glutamate dehydrogenase (GD) and glutamate synthase (GtS) has been determined in the wild strain C3 and on a non excreting pro- mutant strain. Methionine sulfone shows inhibitory effects on their growth. The addition of alpha-ketoglutarate to the medium prevents the inhibitory effect and increases ... | [Effect of methionine sulfone on the growth of Citrobacter intermedius C3 (author's transl)]. Specific activity of glutamate dehydrogenase (GD) and glutamate synthase (GtS) has been determined in the wild strain C3 and on a non excreting pro- mutant strain. Methionine sulfone shows inhibitory effects on their growth. T... | [
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PMID:19821 | Comparative antisecretory activity of several drugs in the gastric fistula squirrel monkey and rat. | A series of known antisecretory compounds, including glycopyrrolate, clonidine, propantheline bromide, CMN 131 (2-pyridylthiocetamide), and desmethylimipramine (DMI) were tested in the gastric fistula rat and monkey. The order of potency for inhibiting acid output was similar in both species. A general similarity exist... | Comparative antisecretory activity of several drugs in the gastric fistula squirrel monkey and rat. A series of known antisecretory compounds, including glycopyrrolate, clonidine, propantheline bromide, CMN 131 (2-pyridylthiocetamide), and desmethylimipramine (DMI) were tested in the gastric fistula rat and monkey. The... | [
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PMID:19822 | The effect of pH on stereospecific opiate binding to mouse brain membranes. | High-affinity, in vitro stereospecific binding of 3H-di-hydromorphine or 3H-naloxone to brain membranes shows a marked dependence on pH; maximal binding, observed at pH 7.5-8.0, is abruptly and reversibly reduced as the pH is lowered, with the binding half-maximal at about pH 6.8. A similar pH dependence of stereospeci... | The effect of pH on stereospecific opiate binding to mouse brain membranes. High-affinity, in vitro stereospecific binding of 3H-di-hydromorphine or 3H-naloxone to brain membranes shows a marked dependence on pH; maximal binding, observed at pH 7.5-8.0, is abruptly and reversibly reduced as the pH is lowered, with the ... | [
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PMID:19818 | [Use of chemical disinfectants in alcoholic fermentation of must of sugar cane molasses]. | The use of hexaclorophene as desinfectant for alcoholic fermentation was studied. Its effect upon alcoholic yield and acidity levels of "beers" and "spirit" was observed. The optimal concentration of hexaclorophene in fermentation broth was found to be 4%. | [Use of chemical disinfectants in alcoholic fermentation of must of sugar cane molasses]. The use of hexaclorophene as desinfectant for alcoholic fermentation was studied. Its effect upon alcoholic yield and acidity levels of "beers" and "spirit" was observed. The optimal concentration of hexaclorophene in fermentation... | [
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PMID:19823 | Red cell lysis coupled to the peroxidation of liver microsomal lipids. Compartmentalization of the hemolytic system. | As a contribution to the understanding of the mechanisms by which addition of erythrocytes to liver microsomes incubated in the NADPH dependent system results in hemolysis, experiments are presented here in which the system containing actively peroxidizing microsomes was separated from the system containing the red blo... | Red cell lysis coupled to the peroxidation of liver microsomal lipids. Compartmentalization of the hemolytic system. As a contribution to the understanding of the mechanisms by which addition of erythrocytes to liver microsomes incubated in the NADPH dependent system results in hemolysis, experiments are presented here... | [
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PMID:19819 | [Isolation of proteins in coconut water]. | The isolation of protein fractions in cocont water was achieved by precipitation with controlled pH variation obtaining three isolates at pH 8,5, 10,5, and 11,5. By comparing each of these isolates with proteins of coconut milk, a similarity between properties of the first two isolates of the water - pH 8,5, 10,5--and ... | [Isolation of proteins in coconut water]. The isolation of protein fractions in cocont water was achieved by precipitation with controlled pH variation obtaining three isolates at pH 8,5, 10,5, and 11,5. By comparing each of these isolates with proteins of coconut milk, a similarity between properties of the first two ... | [
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PMID:19824 | Metal ion catalyzed oxidation of the antibiotic rifampicin. | The metal ions Cu++, Mn++ and Co+++, but not Ca++, Fe+++, K+, La+++, Mg++, Na+, Sr++ or Zn++ catalyzed the oxidation of rifampicin from the naphthohydroquinone to the naphthoquinone form. This reaction was pH dependent, and occurred at neutral or basic pH more rapidly than at acidic pH. Mn++ catalyzed the most rapid ox... | Metal ion catalyzed oxidation of the antibiotic rifampicin. The metal ions Cu++, Mn++ and Co+++, but not Ca++, Fe+++, K+, La+++, Mg++, Na+, Sr++ or Zn++ catalyzed the oxidation of rifampicin from the naphthohydroquinone to the naphthoquinone form. This reaction was pH dependent, and occurred at neutral or basic pH more... | [
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PMID:19825 | Regulation of intracellular cyclic GMP and cyclic AMP levels in mouse lung fragments by disodium cromoglycate, beta-adrenergic agonists, cholinergic activators, and histamine. | The effects of adrenergic and cholinergic agents as well as the effects of disodium cromoglycate (DSCG) on the levels of cyclic AMP and cyclic GMP in mouse lung fragments were studied. Levels of cyclic AMP were enhanced by two of the known beta-adrenergic agonists, epinephrine and isoproterenol. This increase was aboli... | Regulation of intracellular cyclic GMP and cyclic AMP levels in mouse lung fragments by disodium cromoglycate, beta-adrenergic agonists, cholinergic activators, and histamine. The effects of adrenergic and cholinergic agents as well as the effects of disodium cromoglycate (DSCG) on the levels of cyclic AMP and cyclic G... | [
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PMID:19826 | Failure to observe pathology in the rat following chronic dosing with acetaminophen and acetylsalicylic acid. | Male Wistar rats were dosed daily by gavage for 200 days with either (1) aspirin, 200 mg/kg; (2) acetaminophen, 200 mg/kg; (3) aspirin and acetaminophen, 200 mg/kg of each; (4) aspirin and acetaminophen, 100 mg/kg of each or (5) vehicle alone. None of the treatments produced any marked signs of toxicity and no drug rel... | Failure to observe pathology in the rat following chronic dosing with acetaminophen and acetylsalicylic acid. Male Wistar rats were dosed daily by gavage for 200 days with either (1) aspirin, 200 mg/kg; (2) acetaminophen, 200 mg/kg; (3) aspirin and acetaminophen, 200 mg/kg of each; (4) aspirin and acetaminophen, 100 mg... | [
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PMID:19827 | Influence of catecholamine-derived alkaloids and beta-adrenergic blocking agents on stereospecific binding of 3H-naloxone. | Alkaloids containing a catecholamine moiety, viz., tetrahydroisoquinolines and tetrahydroprotoberberines, and a group of beta-adrenergic blocking agents were examined for their effects on the binding of tritiated naloxone by rat brain homogenate. The stereospecific binding of the opiate antagonist was weakly inhibited ... | Influence of catecholamine-derived alkaloids and beta-adrenergic blocking agents on stereospecific binding of 3H-naloxone. Alkaloids containing a catecholamine moiety, viz., tetrahydroisoquinolines and tetrahydroprotoberberines, and a group of beta-adrenergic blocking agents were examined for their effects on the bindi... | [
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PMID:19828 | Comparison of the effects of several selective B2-receptor agonists on bronchomotor function in vitro. | Three selective B2-adrenergic stimulants were studied for their effect on the resting tone and on reversing acetylcholine (ACh)-induced bronchoconstriction in the intrapulmonary airways of rats in vitro. Neither 1-(3,5-dihydroxyphenyl)-2-[(1-[4-hydroxybenzyl]-ethyl)-amino]-ethanol-hydrobromide (Fenoterol) nor 2-tert-bu... | Comparison of the effects of several selective B2-receptor agonists on bronchomotor function in vitro. Three selective B2-adrenergic stimulants were studied for their effect on the resting tone and on reversing acetylcholine (ACh)-induced bronchoconstriction in the intrapulmonary airways of rats in vitro. Neither 1-(3,... | [
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PMID:19829 | [Effect of beta-adrenergic stimulation on the closing volume in normal subjects (author's transl]. | In 12 normal subjets we studies the effects of beta-adrenergic stimulation (Salbutamol, 500 microgram inhaled) on the closing volume (CV) and the closing capacity and on the ratios of these indexes to the vital capacity (VC) and the total lung capacity, respectively. CV and CV/VC % increased in ten subjects wereas it d... | [Effect of beta-adrenergic stimulation on the closing volume in normal subjects (author's transl]. In 12 normal subjets we studies the effects of beta-adrenergic stimulation (Salbutamol, 500 microgram inhaled) on the closing volume (CV) and the closing capacity and on the ratios of these indexes to the vital capacity (... | [
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PMID:19830 | Blood respiratory properties of Bison bison. | The respiratory properties and basic hematology of blood from seven adult bison and one calf were determined. Average oxygen-carrying capacity was 22.2 ml/100 ml blood from adults and 17.0 in calf blood; hemoglobin averaged 17.1 g/100 ml in adults and 13.6 in the calf. Half saturation of the blood occurred at 32mm Hg P... | Blood respiratory properties of Bison bison. The respiratory properties and basic hematology of blood from seven adult bison and one calf were determined. Average oxygen-carrying capacity was 22.2 ml/100 ml blood from adults and 17.0 in calf blood; hemoglobin averaged 17.1 g/100 ml in adults and 13.6 in the calf. Half ... | [
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PMID:19831 | Arterial hydrogen ion versus CO2 on depth and rate of breathing in decerebrate cats. | Arterial blood hydrogen ion concentration (Ha+) was altered over the range of 25 to 110 nM (pH 7.60 to 6.96) by slow intravenous infusion of 1.0 N NaHCO3 or 0.5 N HC1 at controlled levels of Paco2in unanesthetized decerebrate cats. Respiratory f varied as a single function of Vt irrespective of a lterations in Paco2 an... | Arterial hydrogen ion versus CO2 on depth and rate of breathing in decerebrate cats. Arterial blood hydrogen ion concentration (Ha+) was altered over the range of 25 to 110 nM (pH 7.60 to 6.96) by slow intravenous infusion of 1.0 N NaHCO3 or 0.5 N HC1 at controlled levels of Paco2in unanesthetized decerebrate cats. Res... | [
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PMID:19832 | Thermorespiratory responses of shorn and unshorn sheep to mild heat stress. | Three 3-year-old ewes with surgically exteriorized carotid loops were twice exposed to ambient temperatures (Ta) of 25, 30, 35 and 40 C (at constant 40% relative humidity) for 120 min in the presence (6.6 cm) and absence (less than 0.3 cm) of fleece. Thermoregulatory responses were evaluated during the last 30 min of e... | Thermorespiratory responses of shorn and unshorn sheep to mild heat stress. Three 3-year-old ewes with surgically exteriorized carotid loops were twice exposed to ambient temperatures (Ta) of 25, 30, 35 and 40 C (at constant 40% relative humidity) for 120 min in the presence (6.6 cm) and absence (less than 0.3 cm) of f... | [
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PMID:19833 | Effect of simulated altitude on blood gas transport in the pigeon. | Unacclimated pigeons were exposed to various simulated altitudes. Arterial and mixed venous blood gas levels were measured. At the highest altitude 9150m (Pb = 235 mm Hg) a remarkable degree of alkalosis was tolerated for several hours without ill effecrtant factor in the bird's ability to survive such altitudes. | Effect of simulated altitude on blood gas transport in the pigeon. Unacclimated pigeons were exposed to various simulated altitudes. Arterial and mixed venous blood gas levels were measured. At the highest altitude 9150m (Pb = 235 mm Hg) a remarkable degree of alkalosis was tolerated for several hours without ill effec... | [
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PMID:19841 | Calcium fluoride formation on enamel and its influence on uptake of fluoride in the apatitic lattice. | Human dental enamel was exposed to a pH 4 buffer containing 150 parts/10(6) fluoride. It was found that due to the arising degrees of saturation with respect to calcium fluoride and apatites, surface enamel dissolved coincident with a formation of calcium fluoride. The calcium fluoride redissolved while it kept the liq... | Calcium fluoride formation on enamel and its influence on uptake of fluoride in the apatitic lattice. Human dental enamel was exposed to a pH 4 buffer containing 150 parts/10(6) fluoride. It was found that due to the arising degrees of saturation with respect to calcium fluoride and apatites, surface enamel dissolved c... | [
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PMID:19842 | Standardization of the nitroblue tetrazolium test. Influence of pH, dye concentration and sample storage. | The influence of pH, dye concentration and sample storage on the histochemical nitroblue tetrazolium (NBT) test in 45 patients with acute bacterial infections and 51 healthy individuals has been examined. Even minor deviations in pH and NBT dye concentration markedly influenced the reduction of NBT to formazan by patie... | Standardization of the nitroblue tetrazolium test. Influence of pH, dye concentration and sample storage. The influence of pH, dye concentration and sample storage on the histochemical nitroblue tetrazolium (NBT) test in 45 patients with acute bacterial infections and 51 healthy individuals has been examined. Even mino... | [
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PMID:19839 | [Study of a new hypnotic drug: Ro 5-4200 (flunitrazepam)]. | The Authors carried out a clinical study of a new benzodiazepinic derivative (Ro 5-4200) presenting hypnotic properties particularly "interesting". The results emerged from this study confirmed the hypnotic efficacy of the preparation also in case of insomnia of a certain seriousness, as well as its excellent tolerance... | [Study of a new hypnotic drug: Ro 5-4200 (flunitrazepam)]. The Authors carried out a clinical study of a new benzodiazepinic derivative (Ro 5-4200) presenting hypnotic properties particularly "interesting". The results emerged from this study confirmed the hypnotic efficacy of the preparation also in case of insomnia o... | [
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PMID:19843 | Eschaemia during arterial reconstructive surgery. Biochemical changes as reflected in popliteal vein samples. | Blood gases, electrolytes, metabolites and enzymes were studied in the venous effluate from the leg and in the systemic blood of 8 patients suffering from obliterating arteriosclerosis, during and after reconstructive arterial surgery. The common femoral artery was clamped for 50 to 180 min. Marked hypoxia and acidosis... | Eschaemia during arterial reconstructive surgery. Biochemical changes as reflected in popliteal vein samples. Blood gases, electrolytes, metabolites and enzymes were studied in the venous effluate from the leg and in the systemic blood of 8 patients suffering from obliterating arteriosclerosis, during and after reconst... | [
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PMID:19844 | [Use of immunosuppressive agents in systemic diseases]. | The use of immuno-suppressive agents in systemic diseases where the auto-immune origin is probable or certain is not yet based on definite physiopathological evidence. Therefore, it seems essential to use this treatment which has definite side effects only in cases where the progressive nature of the disease, renal com... | [Use of immunosuppressive agents in systemic diseases]. The use of immuno-suppressive agents in systemic diseases where the auto-immune origin is probable or certain is not yet based on definite physiopathological evidence. Therefore, it seems essential to use this treatment which has definite side effects only in case... | [
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PMID:19847 | Demonstration of cryoprecipitable immune complexes in pneumococcal pneumonia. | Cold-insoluble protein complexes (cryoprecipitates) can be found in the serum in a variety of infectious diseases. We studied serum cryoprecipitates isolated from three patients with pneumococcal pneumonia by counterimmunoelectrophoresis (CEP) and immunofluorescent technics for the presence of immune complexes. The cry... | Demonstration of cryoprecipitable immune complexes in pneumococcal pneumonia. Cold-insoluble protein complexes (cryoprecipitates) can be found in the serum in a variety of infectious diseases. We studied serum cryoprecipitates isolated from three patients with pneumococcal pneumonia by counterimmunoelectrophoresis (CEP... | [
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PMID:19845 | [Detection of excessive chronic alcoholic consumption and control of withdrawal. Comparative study of respective values of the mean red-cell volume and serum gamma-glutamyl-transferase activity]. | The routine detection of chronic alcoholism is necessary during any medical examination whether private or in hospital, or in occupational medicine. The practitionner now has available a simple reliable and cheap test. It consists of the serum estimation of gamma-glutamyl-transferase (gammaGT) and interpretation of the... | [Detection of excessive chronic alcoholic consumption and control of withdrawal. Comparative study of respective values of the mean red-cell volume and serum gamma-glutamyl-transferase activity]. The routine detection of chronic alcoholism is necessary during any medical examination whether private or in hospital, or i... | [
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PMID:19850 | Gastric volume and acidity at caesarean section. | The pulmonary acid aspiration (Mendelson's) syndrome may present after regurgitation and inhalation of acid gastric content during obstetric anesthesia. The stomach contents of 70 mothers were aspirated at caesarean section after pre-operative gastric 'emptying' and alkaline ingestion. The acidity of the gastric aspira... | Gastric volume and acidity at caesarean section. The pulmonary acid aspiration (Mendelson's) syndrome may present after regurgitation and inhalation of acid gastric content during obstetric anesthesia. The stomach contents of 70 mothers were aspirated at caesarean section after pre-operative gastric 'emptying' and alka... | [
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PMID:19846 | [Comparative study of a factor-VIII inhibitor in a non-hemophylic patient and in a patient with hemophylia A gravis]. | In this study, we tried to make a comparison between the findings concerning two human strong anti Factor VIII inhibitors. In one case, the strong inhibitor appeared in an old man without any particular antecedant. In the second case, it occurred in a young hemophiliac A. We found in both cases that the inhibitor was a... | [Comparative study of a factor-VIII inhibitor in a non-hemophylic patient and in a patient with hemophylia A gravis]. In this study, we tried to make a comparison between the findings concerning two human strong anti Factor VIII inhibitors. In one case, the strong inhibitor appeared in an old man without any particular... | [
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PMID:19860 | The conjugation of testosterone with horseradish peroxidase and a sensitive enzyme assay for the conjugate. | The formation of a horseradish peroxidase-testosterone conjugate for the enzyme-linked immunoassay of testosterone was investigated, using tritiated testosterone to follow the reaction. The formation of testosterone-3-(carboxymethyl) oxime-peroxidase by the mixed anhydride method was found to give a conjugate of high e... | The conjugation of testosterone with horseradish peroxidase and a sensitive enzyme assay for the conjugate. The formation of a horseradish peroxidase-testosterone conjugate for the enzyme-linked immunoassay of testosterone was investigated, using tritiated testosterone to follow the reaction. The formation of testoster... | [
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PMID:19861 | [Quantitative determination of protector activity of fibrinogen tryptic hydrolysates]. | A method is developed for the quantitative determination of the protector activity. The method is based on registrating the coagulation time shortening for a mixture of fibrin monomer and fragment D. All determinations should be carried out at high concentrations of fragment D when its inhibitory effect on fibrin polym... | [Quantitative determination of protector activity of fibrinogen tryptic hydrolysates]. A method is developed for the quantitative determination of the protector activity. The method is based on registrating the coagulation time shortening for a mixture of fibrin monomer and fragment D. All determinations should be carr... | [
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PMID:19862 | [Effect of phosphoenolpyruvate on creatine kinase activity in rabbit muscles]. | Phosphoenolpyruvate (PEP) is a potent inhibitor of muscle creatine kinase. The inhibition of ATP formation is more pronounced at pH 7.0. The substrates, creatine and creatine phosphate, partially prevent the inhibition of the enzyme activity by PEP, creatine being as an effector. | [Effect of phosphoenolpyruvate on creatine kinase activity in rabbit muscles]. Phosphoenolpyruvate (PEP) is a potent inhibitor of muscle creatine kinase. The inhibition of ATP formation is more pronounced at pH 7.0. The substrates, creatine and creatine phosphate, partially prevent the inhibition of the enzyme activity... | [
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PMID:19863 | [Transfer electron and hydrogen atom in model and enzymatic reactions of NAD and NADP]. | The paper deals with the mechanism of some model reactions of NAD and NADP which proceed with transfer of one electron and hydrogen atom. The joint oxidation of N-benzyl-1,4-dihydronicotinamide (I) and phenylglyoxal with hydrogen peroxide in the presence of cupric ions is found to result in transfer of one hydrogen ato... | [Transfer electron and hydrogen atom in model and enzymatic reactions of NAD and NADP]. The paper deals with the mechanism of some model reactions of NAD and NADP which proceed with transfer of one electron and hydrogen atom. The joint oxidation of N-benzyl-1,4-dihydronicotinamide (I) and phenylglyoxal with hydrogen pe... | [
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PMID:19864 | [Changes in lipid and carbohydrate metabolism in rat tissues under combined effect of hypercapnia, hypoxia and cooling]. | The cooling of rats under conditions of hypercapnia and hypoxia during the first 15 minutes increases the contents of free fatty acids, acetoacetate and beta-oxybutyrate in the tissues of the brain, myocardium, liver, skeletal muscles and blood and decreases them by the end of the effect (120 min later) down to the ini... | [Changes in lipid and carbohydrate metabolism in rat tissues under combined effect of hypercapnia, hypoxia and cooling]. The cooling of rats under conditions of hypercapnia and hypoxia during the first 15 minutes increases the contents of free fatty acids, acetoacetate and beta-oxybutyrate in the tissues of the brain, ... | [
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PMID:19865 | [Peculiarities of aggregation in acid medium of immunoglobulin G peculiar to cancer]. | Immunoglobulin G peculiar to cancer under the effect of acid medium changes to a slightly soluble form due to reversible formation of aggregates. The rest serum proteins transfer to the insoluble form in a more acid medium due to the irreversible denaturation changes in the protein molecules. When isolating aggregates ... | [Peculiarities of aggregation in acid medium of immunoglobulin G peculiar to cancer]. Immunoglobulin G peculiar to cancer under the effect of acid medium changes to a slightly soluble form due to reversible formation of aggregates. The rest serum proteins transfer to the insoluble form in a more acid medium due to the ... | [
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... |
PMID:19866 | [Structural changes in sarcolemma with E-avitaminosis dystrophy]. | Sorption properties of sarcolemma preparations isolated from skeletal muscles of normal and E-avitaminous rabbits were studied relative to organic ions. Analysis of isotherms of sarcolemma equilibrium binding of neutral red cations and turquoise direct lightfast "K" anions made it possible to determine the number of po... | [Structural changes in sarcolemma with E-avitaminosis dystrophy]. Sorption properties of sarcolemma preparations isolated from skeletal muscles of normal and E-avitaminous rabbits were studied relative to organic ions. Analysis of isotherms of sarcolemma equilibrium binding of neutral red cations and turquoise direct l... | [
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PMID:19872 | [Pasteurella multocida bacteriophage adsorption]. | Studied was the adsorption of 8 strains of Pasteurella multocida bacteriophages presenting three groups of phages isolated in Bulgaria. With the bacteriophages of groups I and II the adsorption in broth in the first 10 minutes amounted to 50-65%, and at the 80 the minute reached its maximum value--98-99%. With the bact... | [Pasteurella multocida bacteriophage adsorption]. Studied was the adsorption of 8 strains of Pasteurella multocida bacteriophages presenting three groups of phages isolated in Bulgaria. With the bacteriophages of groups I and II the adsorption in broth in the first 10 minutes amounted to 50-65%, and at the 80 the minut... | [
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PMID:19879 | The effect of dehydroemetine on vascular tissue. | The effect of dehydroemetine on vascular tissues was studied, using the aortic strip of the rabbit, the isolated perfused central ear artery of the rabbit and the perfused hind limb of the cat. Doses from 10(-6) to 10(-5) M inhibited the response of the aortic strip and the perfused ear artery to transmural electrical ... | The effect of dehydroemetine on vascular tissue. The effect of dehydroemetine on vascular tissues was studied, using the aortic strip of the rabbit, the isolated perfused central ear artery of the rabbit and the perfused hind limb of the cat. Doses from 10(-6) to 10(-5) M inhibited the response of the aortic strip and ... | [
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PMID:19884 | The metabolism of niclosamide and related compounds by Moniezia expansa, Ascaris lumbricoides var suum, and mouse- and sheep-liver enzymes. | 1. Niclosamide and related nitro compounds were reduced to the corresponding amines by Moniezia expansa, Ascaris lumbricoides var suum and by enzymes prepared from these species and by mouse and sheep liver homogenates. The reduction of niclosamide by the helminths required as cofactors NADH2 and glutathione, but was i... | The metabolism of niclosamide and related compounds by Moniezia expansa, Ascaris lumbricoides var suum, and mouse- and sheep-liver enzymes. 1. Niclosamide and related nitro compounds were reduced to the corresponding amines by Moniezia expansa, Ascaris lumbricoides var suum and by enzymes prepared from these species an... | [
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PMID:19885 | The metabolism of the neuroleptic agent 1 (4'-fluorophenyl)-4-(cyclohexyl-1'-piperzinyl-4'-carboxylated)-butan-1-one hydrochloride in rats and man. | 1. An oral dose the neuroleptic agent 1-(4'-fluorophenyl)-4-(cyclohexyl-1'-(14C)piperazinyl-4'-carboxylate)butan-1-one was mainly eliminated in the urine within 12 h by rats and man. During 5 days, 63-6% and 83-3% was eliminated in the urine of rats and man respectively. 2. Plasma concentrations in man related a maximu... | The metabolism of the neuroleptic agent 1 (4'-fluorophenyl)-4-(cyclohexyl-1'-piperzinyl-4'-carboxylated)-butan-1-one hydrochloride in rats and man. 1. An oral dose the neuroleptic agent 1-(4'-fluorophenyl)-4-(cyclohexyl-1'-(14C)piperazinyl-4'-carboxylate)butan-1-one was mainly eliminated in the urine within 12 h by rat... | [
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PMID:19886 | [Thermal inactivation and storage behavior of technologically important enzymes. IV. Spinach lipid-acyl-hydrolase]. | The thermal reaction of a lipid-acyl-hydrolase which seems to be important for the quality preservation of vegetable foods, was investigated in spinach. The authors applied a simple in-situ method using thin-layer chromatography which had been developed for the enzyme determination, to follow the thermal inactivation o... | [Thermal inactivation and storage behavior of technologically important enzymes. IV. Spinach lipid-acyl-hydrolase]. The thermal reaction of a lipid-acyl-hydrolase which seems to be important for the quality preservation of vegetable foods, was investigated in spinach. The authors applied a simple in-situ method using t... | [
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PMID:19887 | [Thermal inactivation and storage behavior of technologically important enzymes. I. Horseradish and spinach peroxidase]. | The thermal inactivation and storage behaviour for horseradish and spinach peroxidases were investigated in defined systems, in spinach also within its natural environment. The inactivation curves of either enzyme show a sharp bend which is clearly visible at low, but not at higher temperatures. The D-values were taken... | [Thermal inactivation and storage behavior of technologically important enzymes. I. Horseradish and spinach peroxidase]. The thermal inactivation and storage behaviour for horseradish and spinach peroxidases were investigated in defined systems, in spinach also within its natural environment. The inactivation curves of... | [
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PMID:19888 | [Effects of a coffee-antacid-mixture and a commercial coffee with regard to gastrin, pH and gastric secretion (author's transl)]. | The influence of a coffee-antazid-mixture was investigated at 30 patients with diseases of the stomach (17 with duodenal ulcer, 6 with gastric ulcer and 7 with chronic gastritis) in comparison to a commercial coffee. The parameters measured were the gastric basal acid output, the continuous registration of the pH by an... | [Effects of a coffee-antacid-mixture and a commercial coffee with regard to gastrin, pH and gastric secretion (author's transl)]. The influence of a coffee-antazid-mixture was investigated at 30 patients with diseases of the stomach (17 with duodenal ulcer, 6 with gastric ulcer and 7 with chronic gastritis) in comparis... | [
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PMID:19901 | [Experiences on the effectivity of prostaglandin F2alpha during labor after insufficient effect of oxytocin]. | A report is given about the efficacy of prostaglandin F2alpha for induction of labour after inefficient application of oxytocininfusion. In all cases induction of labour was indicated or labour should be supported. 80 of the 104 women with weak labour finally delivered on vaginal way. Only 9 of 24 caesarean sections we... | [Experiences on the effectivity of prostaglandin F2alpha during labor after insufficient effect of oxytocin]. A report is given about the efficacy of prostaglandin F2alpha for induction of labour after inefficient application of oxytocininfusion. In all cases induction of labour was indicated or labour should be suppor... | [
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PMID:19903 | [Morphofunctional changes in the thymus of semisyngenous chimeras during the "graft versus host" response]. | Activation of the enzymatic processes in the thymus cells was noted in the thymus gland at the early stages of the "transplantat-versus-host" reaction; the later stages were attended by inhibition of metabolic processes and reduction in number of immature and mature thymocytes in the cortical substance of the thymus. B... | [Morphofunctional changes in the thymus of semisyngenous chimeras during the "graft versus host" response]. Activation of the enzymatic processes in the thymus cells was noted in the thymus gland at the early stages of the "transplantat-versus-host" reaction; the later stages were attended by inhibition of metabolic pr... | [
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PMID:19905 | [Dynamic study of blood cholinesterase activity of paranoid schizophrenic patients]. | A comparison of the cholinesterase blood activity with the clinical traits of the disease in 64 patients with paranoid schizophrenia treated by majeptile and haloperidol detected 2 variants in the reactivity of the enzyme link of the cholinergic system. A fluctuation of the cholinesterase activity of the sinusoid type ... | [Dynamic study of blood cholinesterase activity of paranoid schizophrenic patients]. A comparison of the cholinesterase blood activity with the clinical traits of the disease in 64 patients with paranoid schizophrenia treated by majeptile and haloperidol detected 2 variants in the reactivity of the enzyme link of the c... | [
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PMID:19906 | [Sex gland morphology of schizophrenic patients during treatment with psychotropic drugs]. | A macro- and microscopic study of genital glands was conducted in 33 cases of schizophrenia (14 females and 19 males). A practically normal histological picture of the ovary and testis was found in 12 cases, different degrees of involutional (atrophic) changes in 19 and tumours in 2 cases. The degree of expressed histo... | [Sex gland morphology of schizophrenic patients during treatment with psychotropic drugs]. A macro- and microscopic study of genital glands was conducted in 33 cases of schizophrenia (14 females and 19 males). A practically normal histological picture of the ovary and testis was found in 12 cases, different degrees of ... | [
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PMID:19907 | [Several indices of the methylation process in schizophrenic patients]. | The paper deals with a study of 83 patients with different forms of schizophrenia and 15 normals where the methylating activity in converting nicotinamid into methylnicotinamid was determined and the activity of catechol-methyltransferase. In schizophrenic patients there is an increase of the methylating activity which... | [Several indices of the methylation process in schizophrenic patients]. The paper deals with a study of 83 patients with different forms of schizophrenia and 15 normals where the methylating activity in converting nicotinamid into methylnicotinamid was determined and the activity of catechol-methyltransferase. In schiz... | [
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PMID:19909 | The stenosis of the terminal esophagus after surgical repair of the hiatus hernia. | Eighty-two operations of hiatus hernia repair were performed at the General Surgery Department of the University of Padua from 1966 to 1975. Two cases of iatrogenic stenosis of the the terminal esophagus, whose correction required postoperative dilatations, occurred in this series. This complication should be separated... | The stenosis of the terminal esophagus after surgical repair of the hiatus hernia. Eighty-two operations of hiatus hernia repair were performed at the General Surgery Department of the University of Padua from 1966 to 1975. Two cases of iatrogenic stenosis of the the terminal esophagus, whose correction required postop... | [
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PMID:19917 | Saliva tests in the prognosis of caries in children. | The purpose of the investigation was to find out whether the negative correlations between caries indices and the flow rate, pH and buffer effect of saliva that could be demonstrated in groups of 8- and 5-year-old children, were close enough to allow prediction of the development of caries in a given child. The results... | Saliva tests in the prognosis of caries in children. The purpose of the investigation was to find out whether the negative correlations between caries indices and the flow rate, pH and buffer effect of saliva that could be demonstrated in groups of 8- and 5-year-old children, were close enough to allow prediction of th... | [
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PMID:19918 | Ocular encephalitozoonosis (nosematosis) in blue foxes. Polyarteritis nodosa and cataract. | In young blue foxes an association has previously been established between the protozoon Encephalitozoon (Nosema) cuniculi and generalized arterial lesions of the polyarteritis nodosa type. The same vascular changes are found in the posterior ciliary arteries and their intraocular branches of these foxes. Most of the e... | Ocular encephalitozoonosis (nosematosis) in blue foxes. Polyarteritis nodosa and cataract. In young blue foxes an association has previously been established between the protozoon Encephalitozoon (Nosema) cuniculi and generalized arterial lesions of the polyarteritis nodosa type. The same vascular changes are found in ... | [
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PMID:19920 | Role of feeding on lipase activity in gastric contents. | Lipase activity was recorded in gastric contents collected from healthy term and preterm neonates. In contrast to pancreatic lipase activity this lipase activity was higher at pH 5.5 than at pH 8.0 and it was more resistent to acid inactivation. Lipase activity was found in gastric contents from all infants who were re... | Role of feeding on lipase activity in gastric contents. Lipase activity was recorded in gastric contents collected from healthy term and preterm neonates. In contrast to pancreatic lipase activity this lipase activity was higher at pH 5.5 than at pH 8.0 and it was more resistent to acid inactivation. Lipase activity wa... | [
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PMID:19921 | Prevention of kernicterus, based on recent progress in bilirubin chemistry. | A review is presented of recent progress in bilirubin chemistry, its binding to albumin, displacement by drugs, and the mechanism of phototherapy. Quantitative formulations of the effect of albumin dosage, of varying pH, and of fatty acids result in a diagram which may be tried as an aid to indications for therapy. | Prevention of kernicterus, based on recent progress in bilirubin chemistry. A review is presented of recent progress in bilirubin chemistry, its binding to albumin, displacement by drugs, and the mechanism of phototherapy. Quantitative formulations of the effect of albumin dosage, of varying pH, and of fatty acids resu... | [
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PMID:19922 | Chemical composition, serological reactivity and endotoxicity of lipopolysaccharides extracted in different ways from Bacteroides fragilis, Bacteroides melaninogenicus and Bacteroides oralis. | Lipopolysaccharides (LPS) extracted from strains of Bacteroides fragilis, Bacteroides melaninogenicus and Bacteroides oralis with phenol-water, trichloroacetic acid, EDTA or liquid phenol-chloroform-petroleum ether (PCP) and isolated by ultracentrifugation, varied considerably in their quantitative chemical composition... | Chemical composition, serological reactivity and endotoxicity of lipopolysaccharides extracted in different ways from Bacteroides fragilis, Bacteroides melaninogenicus and Bacteroides oralis. Lipopolysaccharides (LPS) extracted from strains of Bacteroides fragilis, Bacteroides melaninogenicus and Bacteroides oralis wit... | [
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PMID:19919 | Purulent and non-purulent maxillary sinus secretions with respect to pO2, pCO2 and pH. | Antral secretions from patients with maxillary sinusitis were aspirated for determination of pO2, pCO2 and pH. In 14 non-purulent secretions the mean pO2 was 12.7 kPa (96 mmHg) and the mean pCO2 5.2 kPa (39 mmHg). The mean pH was slightly alkaline. In 18 purulent secretions, usually with a heavy growth of pneumococci o... | Purulent and non-purulent maxillary sinus secretions with respect to pO2, pCO2 and pH. Antral secretions from patients with maxillary sinusitis were aspirated for determination of pO2, pCO2 and pH. In 14 non-purulent secretions the mean pO2 was 12.7 kPa (96 mmHg) and the mean pCO2 5.2 kPa (39 mmHg). The mean pH was sli... | [
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PMID:19927 | Studies on fish liver protein synthesis. II. Factors influencing the aminoacylation of shark liver transfer ribonucleic acid. | The influence of buffer, pH, Mg2+, ATP, Na+, K+ and temperature on the extent and rate of aminoacyl-tRNA synthesis was studied with the shark Mustelus mento liver tRNAs and aminoacyl-tRNA synthetases. The optimum pH for the aminoacylation of tRNAMet was 8.3 and for tRNAVal 7.0. For these two tRNAs the Mg2+ optimum was ... | Studies on fish liver protein synthesis. II. Factors influencing the aminoacylation of shark liver transfer ribonucleic acid. The influence of buffer, pH, Mg2+, ATP, Na+, K+ and temperature on the extent and rate of aminoacyl-tRNA synthesis was studied with the shark Mustelus mento liver tRNAs and aminoacyl-tRNA synthe... | [
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PMID:19928 | Purchases of hypnotics, sedatives and minor tranquillizers among 2,566 individuals in the county of Jämtland, Sweden. A 6-year follow-up. | Data from a continuous recording of drug prescriptions to 16,600 individuals in the county of Jämtland, Sweden, revealed that 2,566 patients (15.5%) obtained prescriptions for hypnotics, sedatives and minor tranquillizers in 1970. Occasional use (one purchase only, Group A) was seen in 7.4% of the population, intermedi... | Purchases of hypnotics, sedatives and minor tranquillizers among 2,566 individuals in the county of Jämtland, Sweden. A 6-year follow-up. Data from a continuous recording of drug prescriptions to 16,600 individuals in the county of Jämtland, Sweden, revealed that 2,566 patients (15.5%) obtained prescriptions for hypnot... | [
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PMID:19929 | Peripheral haemodynamics in essential hypertension. | Previous studies have indicated the existance of haemodynamically important structural vascular changes in patients and animals with hypertension. Possible pathophysiological implications of these changes are discussed. Two studies dealing with the question of reversibility of the structural changes on long-term blood ... | Peripheral haemodynamics in essential hypertension. Previous studies have indicated the existance of haemodynamically important structural vascular changes in patients and animals with hypertension. Possible pathophysiological implications of these changes are discussed. Two studies dealing with the question of reversi... | [
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PMID:19937 | The oxygen sensing characteristics of microsomal enzymes. | The microsomal electron transport complex, in particular the segment associated with cytochrome P-450 function, is both qualitatively and quantitatively an important contributor to the cellular respiration of tissues such as liver. Although our knowledge is still limited, it is apparent that oxygen plays a pivitol role... | The oxygen sensing characteristics of microsomal enzymes. The microsomal electron transport complex, in particular the segment associated with cytochrome P-450 function, is both qualitatively and quantitatively an important contributor to the cellular respiration of tissues such as liver. Although our knowledge is stil... | [
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PMID:19945 | Evaluation of research on control of prolactin secretion. | At least three substances have been reported to be present in the hypothalamus that can inhibit prolactin release, namely a PIF, catecholamines and acetylcholine. At least four substances have been reported to be present in the hypothalamus that can stimulate prolactin release, namely PRF, TRH, serotonin and prostaglan... | Evaluation of research on control of prolactin secretion. At least three substances have been reported to be present in the hypothalamus that can inhibit prolactin release, namely a PIF, catecholamines and acetylcholine. At least four substances have been reported to be present in the hypothalamus that can stimulate pr... | [
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PMID:19949 | Effect of the diphosphonate EHDP on plasma inorganic phosphate and hemoglobin oxygen affinity of diabetic and healthy subjects. | The effect of oral disodium ethane-1-hydroxy-1,1-diphosphonate, EHDP (20 mg kg-1 day-1) and placebo given for 28 days on plasma inorganic phosphate (Pi) red cell 2,3-diphosphoglycerate and oxygen affinity of hemoglobin was evaluated in 14 insulin-treated diabetics and 5 healthy volunteers. EHDP significantly increased ... | Effect of the diphosphonate EHDP on plasma inorganic phosphate and hemoglobin oxygen affinity of diabetic and healthy subjects. The effect of oral disodium ethane-1-hydroxy-1,1-diphosphonate, EHDP (20 mg kg-1 day-1) and placebo given for 28 days on plasma inorganic phosphate (Pi) red cell 2,3-diphosphoglycerate and oxy... | [
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PMID:19952 | Prolactin release inhibiting and stimulating factors in the hypothalamus. | Catecholamines, especially norepinephrine and dopamine, as well as GABA extracted from porcine hypothalamic tissue, were found to possess PIF activity in vitro. However, more work is needed to determine whether or not the effects of GABA or catecholamines on prolactin release are physiological or pharmacological. Until... | Prolactin release inhibiting and stimulating factors in the hypothalamus. Catecholamines, especially norepinephrine and dopamine, as well as GABA extracted from porcine hypothalamic tissue, were found to possess PIF activity in vitro. However, more work is needed to determine whether or not the effects of GABA or catec... | [
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PMID:19953 | Atypical (relaxant) response to histamine in cat bronchus. | Histamine, 2-methylhistamine (a specific H1-receptor agonist), 4-methylhistamine (a specific H2-receptor agonist), isoprenaline, bradykinin, prostaglandin E1, E2, and F 2alpha induce relaxation of carbachol-contracted isolated cat bronchial strips and tracheal chains. Bovine SRS-A contracts bronchus but not trachea. H... | Atypical (relaxant) response to histamine in cat bronchus. Histamine, 2-methylhistamine (a specific H1-receptor agonist), 4-methylhistamine (a specific H2-receptor agonist), isoprenaline, bradykinin, prostaglandin E1, E2, and F 2alpha induce relaxation of carbachol-contracted isolated cat bronchial strips and tracheal... | [
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PMID:19954 | Tick-borne diseases in the United States: Rocky Mountain spotted fever and Colorado tick fever. A review. | The historical, clinical, ecological, and epidemiological features of Rocky Mountain spotted fever and Colorado tick fever, the two important tick-borne diseases in the United States, are reviewed. Rocky Mountain spotted fever, once considered a disease of the past, has again become a measurable public health problem. ... | Tick-borne diseases in the United States: Rocky Mountain spotted fever and Colorado tick fever. A review. The historical, clinical, ecological, and epidemiological features of Rocky Mountain spotted fever and Colorado tick fever, the two important tick-borne diseases in the United States, are reviewed. Rocky Mountain s... | [
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PMID:19955 | Influences of blood digestion on the development of Plasmodium gallinaceum (Brumpt) in the midgut of Aedes aegypti (L.). | Blood digestion of Aedes aegypti and development of Plasmodium gallinaceum were shifted against each other by giving the mosquitoes two consecutive blood meals. In this way the parasites were exposed to an environment where blood digestion was more advanced than in single blood meals. This procedure had an inhibiting e... | Influences of blood digestion on the development of Plasmodium gallinaceum (Brumpt) in the midgut of Aedes aegypti (L.). Blood digestion of Aedes aegypti and development of Plasmodium gallinaceum were shifted against each other by giving the mosquitoes two consecutive blood meals. In this way the parasites were exposed... | [
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PMID:19957 | Regulation of aerobic fermentation in protozoans. VI Comparative biochemistry of pathogenic and nonpathogenic protozoans. | We have investigated the oxidation of carbohydrate by several protozoan organisms. The oxidation is incomplete and results in a mixture of organic acid and carbon dioxide. The phosphofructokinase and pyruvate kinase, enzymes normally under strict metabolic regulation, are not subject to the normal feedback inhibition o... | Regulation of aerobic fermentation in protozoans. VI Comparative biochemistry of pathogenic and nonpathogenic protozoans. We have investigated the oxidation of carbohydrate by several protozoan organisms. The oxidation is incomplete and results in a mixture of organic acid and carbon dioxide. The phosphofructokinase an... | [
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PMID:19958 | Physiologic interactions between L-proline and D-glucose in Leishmania tarentolae, L. donovani and Trypanosoma scelopori culture forms. | L-proline is more completely catabolized by Leishmania tarentolae and Trypanosoma scelopori than by L. donovani. In the two former organisms the activity of 14CO2 derived from L-proline-14C was as high or higher than that derived from D-glucose-14C; in L. donovani more 14CO2 is derived from D-glucose-14C than from L-pr... | Physiologic interactions between L-proline and D-glucose in Leishmania tarentolae, L. donovani and Trypanosoma scelopori culture forms. L-proline is more completely catabolized by Leishmania tarentolae and Trypanosoma scelopori than by L. donovani. In the two former organisms the activity of 14CO2 derived from L-prolin... | [
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PMID:19959 | Tricarboxylic acid and glyoxylate cycles in the Leishmaniae. | Cell-free extacts of four species of Leishmania (L. brasiliensis, L. donovani, L. mexicana and L. tropica) have been shown to contain all enzymes of the tricarboxylic acid cycle. However, the activity of citrate synthase is so low that it is doubtful whether this pathway is of significance in the metabolism of carbohyd... | Tricarboxylic acid and glyoxylate cycles in the Leishmaniae. Cell-free extacts of four species of Leishmania (L. brasiliensis, L. donovani, L. mexicana and L. tropica) have been shown to contain all enzymes of the tricarboxylic acid cycle. However, the activity of citrate synthase is so low that it is doubtful whether ... | [
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PMID:19960 | Problems in the comparative physiology of some trypanosomatid flagellates. | There is considerable evidence that trypanosomatid species vary in their metabolic characteristics, that they vary in the mechanisms by which they control these characteristics, and that a single species may vary metabolically without varying structurally. Studies to date from a number of laboratories also indicate the... | Problems in the comparative physiology of some trypanosomatid flagellates. There is considerable evidence that trypanosomatid species vary in their metabolic characteristics, that they vary in the mechanisms by which they control these characteristics, and that a single species may vary metabolically without varying st... | [
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PMID:19965 | Testicular venography in the nonpalpable testis. | Localization and identification of a nonpalpable testis can be done accurately by testicular venography. The identification of the pampiniform plexus is essential to the localization of the testis by this method. We evaluated 15 patients 3-39 years of age with 21 nonpalpable testes. Fourteen successful testicular venog... | Testicular venography in the nonpalpable testis. Localization and identification of a nonpalpable testis can be done accurately by testicular venography. The identification of the pampiniform plexus is essential to the localization of the testis by this method. We evaluated 15 patients 3-39 years of age with 21 nonpalp... | [
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PMID:19966 | Polyarteritis nodosa and hepatitis-B surface antigen: role of angiography in diagnosis. | two patients with polyarteritis nodosa who presented with vague constitutional systems and hepatitis-B antigenemia are reported. Angiography was used as the primary diagnostic procedure and confirmed the diagnosis in each case. Angiography is a relatively simple and direct means for establishing the diagnosis of polyar... | Polyarteritis nodosa and hepatitis-B surface antigen: role of angiography in diagnosis. two patients with polyarteritis nodosa who presented with vague constitutional systems and hepatitis-B antigenemia are reported. Angiography was used as the primary diagnostic procedure and confirmed the diagnosis in each case. Angi... | [
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PMID:19968 | Improved quality control of blood acid-base equilibrium using the daily mean of patients' results: a validation study. | The efficiency of the daily mean of patients' results as a quality control tool for acid-base equilibrium has been studied in three one-month periods. Results for the first two periods were obtained in a stable patient population using tonometry in one period, direct measurement of PCO2 in the other; the third period c... | Improved quality control of blood acid-base equilibrium using the daily mean of patients' results: a validation study. The efficiency of the daily mean of patients' results as a quality control tool for acid-base equilibrium has been studied in three one-month periods. Results for the first two periods were obtained in... | [
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PMID:19969 | New method of obtaining cinchophen ulcer in dogs. | Cinchophen injected into the cerebral ventricle reacted with the hypothalamus somewhere in the vicinity ventricle, and produced a release of ACTH as indicated by a rise in peripheral plasma 11-OHCS concentration in the dog. The amount of cinchophen injected into the ventricle corresponds to about 1/600 of the dose requ... | New method of obtaining cinchophen ulcer in dogs. Cinchophen injected into the cerebral ventricle reacted with the hypothalamus somewhere in the vicinity ventricle, and produced a release of ACTH as indicated by a rise in peripheral plasma 11-OHCS concentration in the dog. The amount of cinchophen injected into the ven... | [
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PMID:19971 | Blunted respiratory drive in congenital myopathy. | Two patients with clinically mild congenital myopathies presented with chronic respiratory failure. Muscle weakness alone could not account for the respiratory insufficiency since static respiratory pressures were not markedly impaired, ventilation during exercise was normal, and daytime ventilation was normal if venti... | Blunted respiratory drive in congenital myopathy. Two patients with clinically mild congenital myopathies presented with chronic respiratory failure. Muscle weakness alone could not account for the respiratory insufficiency since static respiratory pressures were not markedly impaired, ventilation during exercise was n... | [
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PMID:19975 | Fetal respiration. A review. | During recent years respiratory movements by the human fetus have been rediscovered. The types of movements have been defined, and their dependence on some physiologic conditions has been described. Pharmacologic agents influence not only the occurrence of the movements but also their rate and depth. A tidal flow of fl... | Fetal respiration. A review. During recent years respiratory movements by the human fetus have been rediscovered. The types of movements have been defined, and their dependence on some physiologic conditions has been described. Pharmacologic agents influence not only the occurrence of the movements but also their rate ... | [
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PMID:19979 | Functional male dyspareunia: a case study. | An apparently successful treatment of a male with a long history of dyspareunia is discussed. The case is unique not only because the subject was male but also in that the etiology was functional. The case demonstrates the multicausal nature of dyspareunia as well as the need for an approach utilizing both a psychodyna... | Functional male dyspareunia: a case study. An apparently successful treatment of a male with a long history of dyspareunia is discussed. The case is unique not only because the subject was male but also in that the etiology was functional. The case demonstrates the multicausal nature of dyspareunia as well as the need ... | [
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PMID:19982 | The thin-layer isoelectric focusing of lactate dehydrogenase isoenzymes in rabbit lens parts and in intraocular tissues. | Lactate dehydrogenase (LDH) isoenzymes of rabbit lens and other intraocular tissues are separated by thin-layer isoelectric focusing and localized as discrete groups of multiple bands with defined isoelectric points after staining by the tetrazolium method. In the rabbit lens parts, the predominant isoenzymes are LDH-4... | The thin-layer isoelectric focusing of lactate dehydrogenase isoenzymes in rabbit lens parts and in intraocular tissues. Lactate dehydrogenase (LDH) isoenzymes of rabbit lens and other intraocular tissues are separated by thin-layer isoelectric focusing and localized as discrete groups of multiple bands with defined is... | [
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PMID:19985 | The effectiveness and duration of preoperative antacid therapy. | The administration of 10 ml of magnesium trisilicate mixture to premedicated patients, maintains the pH of gastric contents below pH 2-5 during subsequent general anaesthesia. This effect was sustained for over seven hours--the longest anaesthetic time studied. No antacid supplementation is required to offer protection... | The effectiveness and duration of preoperative antacid therapy. The administration of 10 ml of magnesium trisilicate mixture to premedicated patients, maintains the pH of gastric contents below pH 2-5 during subsequent general anaesthesia. This effect was sustained for over seven hours--the longest anaesthetic time stu... | [
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PMID:19986 | The effect of hyoscine and atropine on the lower oesophageal sphincter. | The effects of intravenous hyoscine 0-4 mg and atropine 0-6 mg on lower oesophageal sphincter tone were studied in normal human subjects. Hyoscine and atropine both decreased the lower oesophageal sphincter (L.O.S) pressure by approximately 11 cm H2O (p less than 0-01). There was also an increased incidence of reflux a... | The effect of hyoscine and atropine on the lower oesophageal sphincter. The effects of intravenous hyoscine 0-4 mg and atropine 0-6 mg on lower oesophageal sphincter tone were studied in normal human subjects. Hyoscine and atropine both decreased the lower oesophageal sphincter (L.O.S) pressure by approximately 11 cm H... | [
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PMID:19987 | An anaphylactoid reaction to gallamine triethiodide. | A patient suffered profound anaphylactoid reaction during anaesthesia. Intradermal skin testing confirmed the clinical impression that gallamine caused the reaction. The method of testing is discussed. Previous reports of hypersensitivity to the drug are reviewed, and the use of adrenaline, antihistamines and corticost... | An anaphylactoid reaction to gallamine triethiodide. A patient suffered profound anaphylactoid reaction during anaesthesia. Intradermal skin testing confirmed the clinical impression that gallamine caused the reaction. The method of testing is discussed. Previous reports of hypersensitivity to the drug are reviewed, an... | [
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PMID:20002 | [The Bain anesthetic system in facial surgery]. | The BAIN circuit was studied in 11 patients undergoing maxillofacial surgery, with no respiratory deficit, and under spontaneous and assisted ventilation, with a rate of flow of gas of 80, 100, 120, 140 ml/kg/min. From the results it could be concluded that this circuit should be used with a flow of at least 140 ml/kg/... | [The Bain anesthetic system in facial surgery]. The BAIN circuit was studied in 11 patients undergoing maxillofacial surgery, with no respiratory deficit, and under spontaneous and assisted ventilation, with a rate of flow of gas of 80, 100, 120, 140 ml/kg/min. From the results it could be concluded that this circuit s... | [
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PMID:20004 | [Anesthesia with continuous infusion of alfatesine and phenoperidine. Uses in anesthesia of aged subjects in visceral surgery]. | Anaesthesia was administered to one hundred and fifty eight patients by continuous infusion of a mixture of Alfatesine and phenoperidine. The patients were divided on two groups: group A consisted in 96 patients undergoing abdominal surgery and group B of 62 cases of various types of surgery, mainly orthopedics. The av... | [Anesthesia with continuous infusion of alfatesine and phenoperidine. Uses in anesthesia of aged subjects in visceral surgery]. Anaesthesia was administered to one hundred and fifty eight patients by continuous infusion of a mixture of Alfatesine and phenoperidine. The patients were divided on two groups: group A consi... | [
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PMID:20005 | [Action of dibencozide on nitrogen metabolism in immediate and long-term postoperative resuscitation]. | The catabolic orientation of the immediate post-aggression phase is aggravated in neurosurgery by the almost routine prescription of corticosteroids. This emphasises the value of any treatment which might limit this orientation. The authors report their experience with the use of dibencozide, with its known facilitatin... | [Action of dibencozide on nitrogen metabolism in immediate and long-term postoperative resuscitation]. The catabolic orientation of the immediate post-aggression phase is aggravated in neurosurgery by the almost routine prescription of corticosteroids. This emphasises the value of any treatment which might limit this o... | [
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0.039441... |
PMID:20006 | [Percutaneous catheterization of the subclavian vein and/or the Pirogoff angle]. | The approach to the sub-clavian venous axis being carried out blindly, the difficulties encountered oblige one: - to avoid the danger (pleural dome in particular); - to guide the catheter along the sub-clavian axis (and not in the jugular vein) and therefore to know the anatomical landmarks and a precise method. A vari... | [Percutaneous catheterization of the subclavian vein and/or the Pirogoff angle]. The approach to the sub-clavian venous axis being carried out blindly, the difficulties encountered oblige one: - to avoid the danger (pleural dome in particular); - to guide the catheter along the sub-clavian axis (and not in the jugular ... | [
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PMID:20007 | [A case of acute ischemia of the extremities in disseminated intravascular coagulation in an infant]. | The authors report a case of diffuse intravascular coagulation occurring in a 15 day old infant suffering from several congenital malformations (meningocoele, megacolon and bilateral hydronephrosis). During reparative surgery, acute and symmetrical of the lower limbs developed in a context of shock and respiratory dist... | [A case of acute ischemia of the extremities in disseminated intravascular coagulation in an infant]. The authors report a case of diffuse intravascular coagulation occurring in a 15 day old infant suffering from several congenital malformations (meningocoele, megacolon and bilateral hydronephrosis). During reparative ... | [
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0.018423693254590034,
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... |
PMID:20008 | [Early respiratory involvement in burns. Mechanism and prognostic significance]. | A retrospective study, on 87 flame burn patients, of arterial Pa02, chest X-ray and lactic dehydrogenase isoenzyme III revealed the very early onset (before the 24th hour) of severe respiratory problems. This involvement, with a severe prognostic significance, appears to be much more closely related to the extent of th... | [Early respiratory involvement in burns. Mechanism and prognostic significance]. A retrospective study, on 87 flame burn patients, of arterial Pa02, chest X-ray and lactic dehydrogenase isoenzyme III revealed the very early onset (before the 24th hour) of severe respiratory problems. This involvement, with a severe pro... | [
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0.0457... |
PMID:20009 | [Ventilatory disorders in the acute period of tetraplegia of traumatic origin]. | Out of a total of 30 cases of traumatic tetraplegia with the lesion situated from C1 to C8 seen during the acute phase in the department of Professor JUDET, 8 posed no respiratory problems, whilst the others suffered lobar or pulmonary atelectasis in 13 cases, retention of bronchial secretions with secondary infection ... | [Ventilatory disorders in the acute period of tetraplegia of traumatic origin]. Out of a total of 30 cases of traumatic tetraplegia with the lesion situated from C1 to C8 seen during the acute phase in the department of Professor JUDET, 8 posed no respiratory problems, whilst the others suffered lobar or pulmonary atel... | [
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PMID:20010 | [Atypical pulmonary embolism associated with inter-auricular communication]. | A case of massive pulmonary embolism at a patient with undetected atrial defect is reported. The authors discuss the difficulties of establishing a proper diagnosis when the right heart pressure is not raised and when a large emboliser is well tolerated. Angiography confirmed the diagnosis and the patient was successfu... | [Atypical pulmonary embolism associated with inter-auricular communication]. A case of massive pulmonary embolism at a patient with undetected atrial defect is reported. The authors discuss the difficulties of establishing a proper diagnosis when the right heart pressure is not raised and when a large emboliser is well... | [
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... |
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