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PMID:20011 | [The cerebro-cardiac syndrome in neuro-traumatology]. | Head trauma is a possible cause of E.C.G. modifications originating in the brain and unresponsive to pure symptomatic cardial therapy. On the other hand, these perturbations react in a favourable way to treatment aimed at protecting the heart against descending nociceptive influx caused by brain injury. This report sho... | [The cerebro-cardiac syndrome in neuro-traumatology]. Head trauma is a possible cause of E.C.G. modifications originating in the brain and unresponsive to pure symptomatic cardial therapy. On the other hand, these perturbations react in a favourable way to treatment aimed at protecting the heart against descending noci... | [
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PMID:20013 | Medullary carcinoma of the thyroid gland. | Out of the discovery of concurrent multiple endocrine neoplasms has evolved the concept of multiple endocrine adenomatosis (MEA1 and MEA2). Medullary carcinoma of the thyroid gland is the most constant facet of MEA2 and is derived from C-cells of the neural crest. These cells, resembling parafollicular cells of lower a... | Medullary carcinoma of the thyroid gland. Out of the discovery of concurrent multiple endocrine neoplasms has evolved the concept of multiple endocrine adenomatosis (MEA1 and MEA2). Medullary carcinoma of the thyroid gland is the most constant facet of MEA2 and is derived from C-cells of the neural crest. These cells, ... | [
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PMID:20014 | Extrinsic neural influences on gastrointestinal motility. | The gastrointestinal tract is capable of carrying on all its major functions after all extrinsic nerves have been cut. This automaticity is due to the local nervous mechanisms in the walls of the gastrointestinal tract and the inherent properties of the smooth muscles in its walls, and gastrointestinal hormones. All le... | Extrinsic neural influences on gastrointestinal motility. The gastrointestinal tract is capable of carrying on all its major functions after all extrinsic nerves have been cut. This automaticity is due to the local nervous mechanisms in the walls of the gastrointestinal tract and the inherent properties of the smooth m... | [
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PMID:20015 | The switch process in manic-depressive psychosis. | Bipolar manic-depressive illness is a chronic disease in which patients experience recurrent episodes of mania and depression. Patients often change from a nonverbal, retarded depression of many months' duration to a hyperactive, psychotic, manic condition during the switch. The time required for the switch from depres... | The switch process in manic-depressive psychosis. Bipolar manic-depressive illness is a chronic disease in which patients experience recurrent episodes of mania and depression. Patients often change from a nonverbal, retarded depression of many months' duration to a hyperactive, psychotic, manic condition during the sw... | [
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PMID:20017 | Ecology of Keystone virus, a transovarially maintained arbovirus. | Our studies in the Pocomoke Cypress Swamp of Maryland have shown that KEY strain of CE is endemic and is carried by the floodwater mosquito A. atlanticus. The virus is transmitted transstadially in nature, as evidenced by our recovery of virus from larvae and males of this species. Serologic evidence, both here and els... | Ecology of Keystone virus, a transovarially maintained arbovirus. Our studies in the Pocomoke Cypress Swamp of Maryland have shown that KEY strain of CE is endemic and is carried by the floodwater mosquito A. atlanticus. The virus is transmitted transstadially in nature, as evidenced by our recovery of virus from larva... | [
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PMID:20018 | Transovarial transmission of Rickettsia-like microorganisms in mosquitoes. | The wolbachiae found in Culex pipiens and the Tafahi strain of the A. scutellaris group are small rickettsia-like symbionts of the gonads. They are extrachromosomal self-replicating units that are vertically transmitted through the ovaries. Their presence in the only two groups of mosquitoes known to exhibit incompatib... | Transovarial transmission of Rickettsia-like microorganisms in mosquitoes. The wolbachiae found in Culex pipiens and the Tafahi strain of the A. scutellaris group are small rickettsia-like symbionts of the gonads. They are extrachromosomal self-replicating units that are vertically transmitted through the ovaries. Thei... | [
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PMID:20019 | [Nitrates and nitrites in plants]. | The formation of aminoacids and proteins from the nitrogen which enters the roots as nitra t involves a complex reaction requiring energy. The first step requires a metalloflavoprotein, the nitrate reductase and the successive intervention of NADPH, FAD and reduced molybdenum which transfers electrons to nitrate and re... | [Nitrates and nitrites in plants]. The formation of aminoacids and proteins from the nitrogen which enters the roots as nitra t involves a complex reaction requiring energy. The first step requires a metalloflavoprotein, the nitrate reductase and the successive intervention of NADPH, FAD and reduced molybdenum which tr... | [
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PMID:20020 | [Formation of nitrosamines in the digestive tract]. | Nitrosamines are carcinogenic compounds synthetized from amines and nitrites or nitrates, if nitrates in the reaction medium may be reduced to nitrites. Nitrosation is determined in the digestive tract of several species of laboratory animals. Two physiochemical factors appear to determine in vitro nitrosamine formatio... | [Formation of nitrosamines in the digestive tract]. Nitrosamines are carcinogenic compounds synthetized from amines and nitrites or nitrates, if nitrates in the reaction medium may be reduced to nitrites. Nitrosation is determined in the digestive tract of several species of laboratory animals. Two physiochemical facto... | [
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PMID:20022 | [Metabolism of nitrates-nitrites]. | Once the pair nitrate-nitrite--in quantity respectively set by the ingestion level or transformation level by intestinal bacteria--has entered through the intestinal mucosa, it may react with active biochemical groups. Nitrite, owing to its high oxido-reduction potential, may induce the oxidation of a large number of c... | [Metabolism of nitrates-nitrites]. Once the pair nitrate-nitrite--in quantity respectively set by the ingestion level or transformation level by intestinal bacteria--has entered through the intestinal mucosa, it may react with active biochemical groups. Nitrite, owing to its high oxido-reduction potential, may induce t... | [
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PMID:20023 | [Effect of nitrites and nitrates on various aspects of vitamin nutritional status]. | Nitrites--and sometimes nitrates--decrease the biological availability of dietary vitamins in several animal species. 1. Numerous studies show that ingested nitrites decrease the stock of liver vitamin A in nonruminants (Rat, Pig, Chicken); the effect of nitrates is less pronounced even lacking. In vitro, experiments a... | [Effect of nitrites and nitrates on various aspects of vitamin nutritional status]. Nitrites--and sometimes nitrates--decrease the biological availability of dietary vitamins in several animal species. 1. Numerous studies show that ingested nitrites decrease the stock of liver vitamin A in nonruminants (Rat, Pig, Chick... | [
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PMID:20025 | pH of blood and aqueous in patients with glaucoma. | pH estimation of blood was carried out in 37 normal patients and 43 patients with chronic simple glaucoma. pH of blood did not show any statistical significant difference in the 2 groups. pH of aqueous also was noted in 8 patients with glaucoma and 8 normal patients and no significant difference was noted. | pH of blood and aqueous in patients with glaucoma. pH estimation of blood was carried out in 37 normal patients and 43 patients with chronic simple glaucoma. pH of blood did not show any statistical significant difference in the 2 groups. pH of aqueous also was noted in 8 patients with glaucoma and 8 normal patients an... | [
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PMID:20027 | Bradshaw lecture, 1976. Thyroid medullary carcinoma. | The main characteristics of medullary carcinoma of the thyroid are its non-follicular histological appearance, resulting from its origin from the parafollicular C cells, its secretion of calcitonin, providing a relatively simple diagnostic test, and its equal sex incidence, in contrast to all other diseases of the thyr... | Bradshaw lecture, 1976. Thyroid medullary carcinoma. The main characteristics of medullary carcinoma of the thyroid are its non-follicular histological appearance, resulting from its origin from the parafollicular C cells, its secretion of calcitonin, providing a relatively simple diagnostic test, and its equal sex inc... | [
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PMID:20028 | Determination of serum creatinine by reaction with methyl-3,5-dinitrobenzoate in Methyl Sulfoxide. | Creatinine in serum is determined with a new reagent system consisting of methyl-3,5-dinitrobenzoate and tetramethyl ammonium hydroxide in 50% methyl sulfoxide. The method shows excellent correlation with manual and automated alkaline picrate procedures and has comparable sensitivity. The proposed method has advantages... | Determination of serum creatinine by reaction with methyl-3,5-dinitrobenzoate in Methyl Sulfoxide. Creatinine in serum is determined with a new reagent system consisting of methyl-3,5-dinitrobenzoate and tetramethyl ammonium hydroxide in 50% methyl sulfoxide. The method shows excellent correlation with manual and autom... | [
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PMID:20026 | [Variation of the anhidrotic activities of anticholinergics with different routes of administration (author's transl)]. | Anhidrotic concentrations 50 of four anticholinergics were determined in mice using an original skin palmar conductance method. Intra-peritoneal, intra-palmar and topical routes were compared. Relative anhidrotic activities according to the mode of administration of the different anticholinergics showed definite differ... | [Variation of the anhidrotic activities of anticholinergics with different routes of administration (author's transl)]. Anhidrotic concentrations 50 of four anticholinergics were determined in mice using an original skin palmar conductance method. Intra-peritoneal, intra-palmar and topical routes were compared. Relativ... | [
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PMID:20029 | Human pancreatic alpha-amylase. II. Effects of pH, substrate and ions on the activity of the enzyme. | Purified human pancreatic alpha-amylase (alpha-1,4-glucan 4-glucano-hydrolase, EC 3.2.1.1) was found to be stable over a wide range of pH values (5.0 to 10.5) with an optimal pH for the enzymatic activity of 7.0. The Michaelis constant of the enzyme at optimal pH and assay conditions was found to be 2.51 mg per ml for ... | Human pancreatic alpha-amylase. II. Effects of pH, substrate and ions on the activity of the enzyme. Purified human pancreatic alpha-amylase (alpha-1,4-glucan 4-glucano-hydrolase, EC 3.2.1.1) was found to be stable over a wide range of pH values (5.0 to 10.5) with an optimal pH for the enzymatic activity of 7.0. The Mi... | [
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PMID:20030 | Glucose-6-phosphate dehydrogenase in vitro correlated with in vivo activity and reticulocytosis. | In vitro activity of erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) does not always correlate with in vivo hemolytic manifestations. Many of these non-correlations are reviewed and can now be explained on the basis of altered substrate affinity and/or altered inhibition by intracellular metabolites. These alter... | Glucose-6-phosphate dehydrogenase in vitro correlated with in vivo activity and reticulocytosis. In vitro activity of erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) does not always correlate with in vivo hemolytic manifestations. Many of these non-correlations are reviewed and can now be explained on the basis ... | [
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PMID:20032 | [Effects of a vagolytic substance on the circadian rhythm of the ACTH-secreting system in man]. | The circadian rhythm of plasma cortisol and urinary 17-hydroxy-corticosteroids has been studied in 6 normal volunteers both in basal conditions and after the administration of a single dose of 30 mg of a banthine derivative (the beta methyl-beta-isopropylaminoethyl ester bromide of xantene-9-carbonic acid, "Pervagal") ... | [Effects of a vagolytic substance on the circadian rhythm of the ACTH-secreting system in man]. The circadian rhythm of plasma cortisol and urinary 17-hydroxy-corticosteroids has been studied in 6 normal volunteers both in basal conditions and after the administration of a single dose of 30 mg of a banthine derivative ... | [
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PMID:20033 | Chemotaxis of leucocytes: an improved method of direct microscopic observation. | Leucochemotaxis was evaluated by direct morphological observation of a cell suspension between slide and coverslip. The chemotactic index was obtained by the ratio of the number of moving leucocytes recorded within an area limited on the slide by circles traced, at the beginning and after a time period of exposure to a... | Chemotaxis of leucocytes: an improved method of direct microscopic observation. Leucochemotaxis was evaluated by direct morphological observation of a cell suspension between slide and coverslip. The chemotactic index was obtained by the ratio of the number of moving leucocytes recorded within an area limited on the sl... | [
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PMID:20044 | Comparative stability of cephalothin and cefazolin in buffer or human serum. | A marked loss in potency was observed when cephalothin was incubated for 5 h in human serum at 37 degrees C. Cefazolin was stable under these conditions. | Comparative stability of cephalothin and cefazolin in buffer or human serum. A marked loss in potency was observed when cephalothin was incubated for 5 h in human serum at 37 degrees C. Cefazolin was stable under these conditions. | [
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PMID:20062 | New health practitioners and dermatology manpower planning. | To assess the need for dermatologists in the United States, the potential role of new health practitioners in this specialty is considered. Available data on physician extenders in general and informed opinion on dermatologist extenders in particular suggest that specially trained, nonphysician personnel could substant... | New health practitioners and dermatology manpower planning. To assess the need for dermatologists in the United States, the potential role of new health practitioners in this specialty is considered. Available data on physician extenders in general and informed opinion on dermatologist extenders in particular suggest t... | [
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PMID:20063 | The Environmental fate of three carcinogens: benzo-(alpha)-pyrene, benzidine, and vinyl chloride evaluated in laboratory model ecosystems. | Radiolabeled benzo-((alpha)-pyrene, benzidine, and vinyl chloride were evaluated in laboratory model ecosystems for environmental fate, degradation pathways, bioconcentration, and food chain accumulation. The comparative effects of microsomal detoxications were evaluated using the inhibitor piperonyl butoxide. The accu... | The Environmental fate of three carcinogens: benzo-(alpha)-pyrene, benzidine, and vinyl chloride evaluated in laboratory model ecosystems. Radiolabeled benzo-((alpha)-pyrene, benzidine, and vinyl chloride were evaluated in laboratory model ecosystems for environmental fate, degradation pathways, bioconcentration, and f... | [
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PMID:20067 | The effect of beta-adrenoceptor antagonists on the alpha-adrenoceptor blockade produced by phenoxybenzamine. | The effect of beta-adrenoceptor antagonists on the irreversible alpha-adrenoceptor blockade produced by phenoxybenzamine was studied in dogs. The pressor effects of adrenaline were revived after the inhibition by the alpha-receptor block by (+/-) propranolol, (-) INPEA, (+/-) MJ 1999 and (+/-) butoxamine. The enantiome... | The effect of beta-adrenoceptor antagonists on the alpha-adrenoceptor blockade produced by phenoxybenzamine. The effect of beta-adrenoceptor antagonists on the irreversible alpha-adrenoceptor blockade produced by phenoxybenzamine was studied in dogs. The pressor effects of adrenaline were revived after the inhibition b... | [
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PMID:20068 | [Quantitative composition of the gastrointestinal flora in the young pig]. | Studies were conducted into the quantitative composition of the gastro-intestinal flora in clinically intact store pigs. The methods are described in greater detail, followed by presentation of results. In the discussion particular reference is made to literature. Conclusions are drawn regarding the topographic distrib... | [Quantitative composition of the gastrointestinal flora in the young pig]. Studies were conducted into the quantitative composition of the gastro-intestinal flora in clinically intact store pigs. The methods are described in greater detail, followed by presentation of results. In the discussion particular reference is ... | [
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PMID:20069 | [Alterations of cerebrospinal fluid pressure in experimental communicating hydrocephalus. Response of CSF-pressure to increased CO2-tension (author's transl)]. | The response of cerebrospinal fluid pressure to increased arterial carbon dioxide tension was examined in 5 control dogs and 7 dogs with experimental communicating hydrocephalus. The cerebrospinal fluid pressure in control animals only rose to 35 mm Hg after elevation of the arterial CO2 tension. In dogs with experimen... | [Alterations of cerebrospinal fluid pressure in experimental communicating hydrocephalus. Response of CSF-pressure to increased CO2-tension (author's transl)]. The response of cerebrospinal fluid pressure to increased arterial carbon dioxide tension was examined in 5 control dogs and 7 dogs with experimental communicat... | [
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PMID:20070 | [Clinical trial with a new anti-epileptic: barbexaclone]. | A new anti-epileptic agent (barbexaclone) was tried in 48 patients suffering from epilepsy and presenting a total of 67 types of crises. All the patients were considered "bad cases" because either by the intensity of the epileptic manifestations or by their refractoriness to the usual medications. The results, similar ... | [Clinical trial with a new anti-epileptic: barbexaclone]. A new anti-epileptic agent (barbexaclone) was tried in 48 patients suffering from epilepsy and presenting a total of 67 types of crises. All the patients were considered "bad cases" because either by the intensity of the epileptic manifestations or by their refr... | [
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PMID:20072 | Generalized glycogenosis in beef shorthorn cattle--heterozygote detection. | A preliminary study of acidic alpha-glucosidase in a variety of tissues was carried out in an attempt to develop a test which might be used to detect individuals heterozygous for the genetype associated with generalized glycogenosis in beef Shorthorn cattle. Of the tissues readily available peripheral lymphocytes were ... | Generalized glycogenosis in beef shorthorn cattle--heterozygote detection. A preliminary study of acidic alpha-glucosidase in a variety of tissues was carried out in an attempt to develop a test which might be used to detect individuals heterozygous for the genetype associated with generalized glycogenosis in beef Shor... | [
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PMID:20077 | 4,4'-dimethylcholesta-7,9,14-trienol is an intermediate in the demethylation of dihydroagnosterol. | 1. 4,4'-Dimethylcholesta-7,9,14-trienol is an intermediate in the metabolism of dihydroagnosterol to cholesterol by rat liver homogenate. 2. This triene is reduced by a rat liver microsomal preparation in the presence of NADPH to give 4,4'-dimethylcholesta-7,9-dienol under anaerobic conditions. 3. Reduction of the trie... | 4,4'-dimethylcholesta-7,9,14-trienol is an intermediate in the demethylation of dihydroagnosterol. 1. 4,4'-Dimethylcholesta-7,9,14-trienol is an intermediate in the metabolism of dihydroagnosterol to cholesterol by rat liver homogenate. 2. This triene is reduced by a rat liver microsomal preparation in the presence of ... | [
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PMID:20112 | [In vitro studies on parsalmide / bioavailability and protein binding (author's transl)]. | The values of the diffusion constants at the different pH-values obtained using Stricker's apparatus, demonstrate that 2-propargyloxy-5-amino-N-(n-butyl)-benzamide(parsalmide, My 46-1) is characterized by a good absorption rate at gastric level and by a high absorption rate in the intestinal tract. The per cent of pars... | [In vitro studies on parsalmide / bioavailability and protein binding (author's transl)]. The values of the diffusion constants at the different pH-values obtained using Stricker's apparatus, demonstrate that 2-propargyloxy-5-amino-N-(n-butyl)-benzamide(parsalmide, My 46-1) is characterized by a good absorption rate at... | [
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PMID:20114 | Bufuralol, a new beta-adrenoceptor blocking agent in a series of benzofuran-2-ethanolamines. Part 2: pharmacology. | 1-(7-Ethylbenzofuran-2-yl)-2-tert.-butylamino-1-hydroxyethane hydrochloride (bufuralol) is a non-selective beta-adrenoceptor blocking agent which closely resembles propranolol in its properties, including potency. Bufuralol is devoid of alpha-adrenoceptor blocking activity but possesses beta-adrenoceptor agonist activi... | Bufuralol, a new beta-adrenoceptor blocking agent in a series of benzofuran-2-ethanolamines. Part 2: pharmacology. 1-(7-Ethylbenzofuran-2-yl)-2-tert.-butylamino-1-hydroxyethane hydrochloride (bufuralol) is a non-selective beta-adrenoceptor blocking agent which closely resembles propranolol in its properties, including ... | [
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PMID:20111 | Local and systemic reactions to puncture injuries by the sea urchin spine and the date palm thorn. | Puncture wounds were cuased in 9 patients by sea urchin spines and 1 patient by a date palm thorn. All 10 patients developed local inflammatory reactions, which were moderate to severe in 7. Two patients exhibited severe systemic illnesses, and a marked synovitis was present in 2 others. Several of the patients present... | Local and systemic reactions to puncture injuries by the sea urchin spine and the date palm thorn. Puncture wounds were cuased in 9 patients by sea urchin spines and 1 patient by a date palm thorn. All 10 patients developed local inflammatory reactions, which were moderate to severe in 7. Two patients exhibited severe ... | [
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PMID:20116 | Amiodarone-like haemodynamic and non-competitive antiadrenergic properties of a benzoyl-indolizine. | 1. 2-Ethyl-3-(4-gamma-di-n-butylaminopropoxy-benzoyl)-indolizine hydrochloride (L 9394) induced in the ananesthetized dog a marked and long-lasting decrease in heart rate together with a transient reduction in blood pressure. 2. L 9394 decreased Robinson's index, an effect which suggests that the substance reduces the ... | Amiodarone-like haemodynamic and non-competitive antiadrenergic properties of a benzoyl-indolizine. 1. 2-Ethyl-3-(4-gamma-di-n-butylaminopropoxy-benzoyl)-indolizine hydrochloride (L 9394) induced in the ananesthetized dog a marked and long-lasting decrease in heart rate together with a transient reduction in blood pres... | [
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PMID:20124 | The effect of mental arithmetic in normotensive and hypertensive subjects, and its modification by beta-adrenergic receptor blockade. | 1 The effects of a 5-min period of sustained mental arithmetic upon blood pressure and heart rate were determined in several groups of healthy subjects and hypertensive patients. 2 The arithmetic produced significant increases in heart rate and blood pressure (both systolic and diastolic) in both normotensive and hyper... | The effect of mental arithmetic in normotensive and hypertensive subjects, and its modification by beta-adrenergic receptor blockade. 1 The effects of a 5-min period of sustained mental arithmetic upon blood pressure and heart rate were determined in several groups of healthy subjects and hypertensive patients. 2 The a... | [
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PMID:20126 | Rupture of base pairing in double-stranded poly(riboadenylic acid)-poly(ribouridylic acid) by formaldehyde: medium chain lenghts. | By assuming that the opening of hydrogen bonds due to thermal fluctuations is a very fast step and that the reaction of formaldehyde with the imino or amino group is a slow step, we have constructed a model for the unwinding process of poly(A-U) induced by formaldehyde. The denaturation equation derived from the model ... | Rupture of base pairing in double-stranded poly(riboadenylic acid)-poly(ribouridylic acid) by formaldehyde: medium chain lenghts. By assuming that the opening of hydrogen bonds due to thermal fluctuations is a very fast step and that the reaction of formaldehyde with the imino or amino group is a slow step, we have con... | [
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PMID:20127 | Magnetic resonance investigation of ionizable residues at the active site of thermolysin. | The details of the pH dependence of the thermodynamic and magnetic interactions of the active-site region of thermolysin in which manganese has replaced the active-site zinc atom and the inhibitor N-trifluoroacetyl-D-phenylalanine have been examined. These show a number of ionizable groups in the active-site region. A ... | Magnetic resonance investigation of ionizable residues at the active site of thermolysin. The details of the pH dependence of the thermodynamic and magnetic interactions of the active-site region of thermolysin in which manganese has replaced the active-site zinc atom and the inhibitor N-trifluoroacetyl-D-phenylalanine... | [
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PMID:20134 | Studies on the reactive properties of histone amino groups: reactivities of free histones and histones in chromatin as a function of ionic strength. | The reactivity of the amino groups of the five histones towards acetic anhydride has been measured and with the exception of histone IIb2 the reactivities are very similar to those of exposed lysines with an average pK of 9.5. In addition the reactivities of these groups from 0.20 to 1.0 M NaCl and the reactivity of a ... | Studies on the reactive properties of histone amino groups: reactivities of free histones and histones in chromatin as a function of ionic strength. The reactivity of the amino groups of the five histones towards acetic anhydride has been measured and with the exception of histone IIb2 the reactivities are very similar... | [
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PMID:20136 | pH-dependent changes in proton:substrate stoichiometries during active transport in Escherichia coli membrane vesicles. | Experiments are presented in which the proton electrochemical gradient (deltamuH+) IN Escherichia coli membrane vesicles (interior negative and alkaline) was measured under a variety of conditions and compared with steady-state levels of accumulation of lactose, proline, D-lactate, and glucose-6-P measured under identi... | pH-dependent changes in proton:substrate stoichiometries during active transport in Escherichia coli membrane vesicles. Experiments are presented in which the proton electrochemical gradient (deltamuH+) IN Escherichia coli membrane vesicles (interior negative and alkaline) was measured under a variety of conditions and... | [
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PMID:20141 | Weak acid accumulation in the serosal extracellular compartment of the frog gastric mucosa. | The dimethyloxazolidine dione distribution in the extracellular compartments of the frog gastric mucosa was analyzed by washout kinetics. The volumes of the two extracellular compartments, serosal and mucosal, were estimated by inulin washout as 0.435 +/- 0.019 and 0.176 +/- 0.018 microliter/microliter tissue water, re... | Weak acid accumulation in the serosal extracellular compartment of the frog gastric mucosa. The dimethyloxazolidine dione distribution in the extracellular compartments of the frog gastric mucosa was analyzed by washout kinetics. The volumes of the two extracellular compartments, serosal and mucosal, were estimated by ... | [
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PMID:20142 | Intracellular pH and the kinetics of Rb+ uptake by yeast non-carrier versus mobile carrier-mediated uptake. | The effect of changes in the intracellular pH upon the concentration dependence of the Rb+ uptake by yeast is investigated. It is shown, that the uptake of Rb+ can be described by a mechanism in which the total concentration of primary binding sites at the outer side of the membrane is independent of the intracellular ... | Intracellular pH and the kinetics of Rb+ uptake by yeast non-carrier versus mobile carrier-mediated uptake. The effect of changes in the intracellular pH upon the concentration dependence of the Rb+ uptake by yeast is investigated. It is shown, that the uptake of Rb+ can be described by a mechanism in which the total c... | [
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PMID:20143 | Active transport of L-sorbose and 2-deoxy-D-galactose in Saccharomyces fragilis. | Sorbose and 2-deoxy-D-galactose are taken up in Saccharomyces fragilis by an active transport mechanism, as indicated by the energy requirement of the process and the accumulation of free sugar against the concentration gradient. There are no indications for transport-associated phosphorylation as mechanism of energy c... | Active transport of L-sorbose and 2-deoxy-D-galactose in Saccharomyces fragilis. Sorbose and 2-deoxy-D-galactose are taken up in Saccharomyces fragilis by an active transport mechanism, as indicated by the energy requirement of the process and the accumulation of free sugar against the concentration gradient. There are... | [
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PMID:20144 | Phase transition in charged lipid membranes. | Experimental results on the effect of electrostatics on bilayer phase transitions are compared with corresponding data for monolayers and the predictions of electrical double layer theory. The two substantial conclusions which emerge are that: (i) double layer theory based on a continuous surface charge distribution ca... | Phase transition in charged lipid membranes. Experimental results on the effect of electrostatics on bilayer phase transitions are compared with corresponding data for monolayers and the predictions of electrical double layer theory. The two substantial conclusions which emerge are that: (i) double layer theory based o... | [
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PMID:20145 | Interaction of phosphate with monovalent cation uptake in yeast. | The uptake of monovalent cations by yeast via the monovalent cation uptake mechanism is inhibited by phosphate. The inhibition of Rb+ uptake shows saturation kinetics and the phosphate concentration at which half-maximal inhibition is observed is equal to the Km of phosphate for the sodium-independent phosphate uptake ... | Interaction of phosphate with monovalent cation uptake in yeast. The uptake of monovalent cations by yeast via the monovalent cation uptake mechanism is inhibited by phosphate. The inhibition of Rb+ uptake shows saturation kinetics and the phosphate concentration at which half-maximal inhibition is observed is equal to... | [
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PMID:20146 | Endonuclease activity in nuclei of Physarum polycephalum. Partial purification and characterization. | An endonuclease, present in the microplasmodia of Physarum polycephalum, has been partially purified from isolated nuclei by DEAE-cellulose and Sephadex G-75 chromatography. 1. The endonuclease produced single-strand scissions in double-stranded DNA which resulted in the generation of 5'-phosphoryl and 3'-hydroxyl term... | Endonuclease activity in nuclei of Physarum polycephalum. Partial purification and characterization. An endonuclease, present in the microplasmodia of Physarum polycephalum, has been partially purified from isolated nuclei by DEAE-cellulose and Sephadex G-75 chromatography. 1. The endonuclease produced single-strand sc... | [
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PMID:20147 | Purification, crystallization and properties of triacylglycerol lipase from Pseudomonas fluorescens. | Triacylglycerol lipase of Pseudomonas fluorescens was purified from the crude enzyme by ammonium sulfate precipitation and chromatographies on Sephadex G-75 and DEAE-cellulose. The crystallization of the lipase was successfully carried out. The purified lipase was demonstrated to be homogenous on disc electrophoresis a... | Purification, crystallization and properties of triacylglycerol lipase from Pseudomonas fluorescens. Triacylglycerol lipase of Pseudomonas fluorescens was purified from the crude enzyme by ammonium sulfate precipitation and chromatographies on Sephadex G-75 and DEAE-cellulose. The crystallization of the lipase was succ... | [
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PMID:20148 | Two cholesterol ester hydrolases. Distribution in rat tissues and in cultured human fibroblasts and monkey arterial smooth muscle cells. | Hydrolytic activity against acetone-dispersed [4-14C]cholesterol oleate has been assayed as a function of pH in seven parenchymal tissues, blood cells, and plasma of the rat, as well as in cultured human fibroblasts and monkey (Macaca nemestrina) arterial smooth muscle cells. Both acid and neutral hydrolytic activities... | Two cholesterol ester hydrolases. Distribution in rat tissues and in cultured human fibroblasts and monkey arterial smooth muscle cells. Hydrolytic activity against acetone-dispersed [4-14C]cholesterol oleate has been assayed as a function of pH in seven parenchymal tissues, blood cells, and plasma of the rat, as well ... | [
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PMID:20149 | Studies on Tetrahymena membranes. Palmitoyl-coenzyme a desaturase, a possible key enzyme for temperature adaptation in Tetrahymena microsomes. | (1) Microsomes from a thermotolerant Tetrahymena NT-1 catalyze the conversion of palmitoyl-CoA to palmitoleate. (2) Palmitoyl-CoA desaturase enzyme requires molecular oxygen and NADH or NADPH as cofactor and its activity is inhibited by cyanide. A pH optimum range 7.0--7.3 is observed. (3) There is a clear break at 30 ... | Studies on Tetrahymena membranes. Palmitoyl-coenzyme a desaturase, a possible key enzyme for temperature adaptation in Tetrahymena microsomes. (1) Microsomes from a thermotolerant Tetrahymena NT-1 catalyze the conversion of palmitoyl-CoA to palmitoleate. (2) Palmitoyl-CoA desaturase enzyme requires molecular oxygen and... | [
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PMID:20150 | Neutral lipid biosynthesis in Mycobacterium smegmatis. | The biosynthesis of neutral lipids in Mycobacterium smegmatis was studied using cell free extracts. Maximum neutral lipid production was obtained when the reaction mixture (400 microliter) consisted of 0.25 M potassium phosphate buffer (pH 7.5), 0.125 mM oleoyl-CoA, 3.75 mM sn-glycerol-3-P, 10 mM MgCl2 and 1.85 mg bovi... | Neutral lipid biosynthesis in Mycobacterium smegmatis. The biosynthesis of neutral lipids in Mycobacterium smegmatis was studied using cell free extracts. Maximum neutral lipid production was obtained when the reaction mixture (400 microliter) consisted of 0.25 M potassium phosphate buffer (pH 7.5), 0.125 mM oleoyl-CoA... | [
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PMID:20151 | Physicochemical and functional properties of Perinereis cultrifera (Grübe) erythrocruorin. | Perinereis erythrocruorin has the following physicochemical properties: So20,w = 55S, corresponding to a molecular weight around 2.7-10(6); minimum molecular weight (on the basis of the heme content) 23 700 +/- 500; isoelectric point 5.1; alpha-helix content approximately 40%. At alkaline pH values in the oxygenated fo... | Physicochemical and functional properties of Perinereis cultrifera (Grübe) erythrocruorin. Perinereis erythrocruorin has the following physicochemical properties: So20,w = 55S, corresponding to a molecular weight around 2.7-10(6); minimum molecular weight (on the basis of the heme content) 23 700 +/- 500; isoelectric p... | [
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PMID:20152 | The pH dependence of the resonance raman spectra and structural alterations at heme moieties of various c-type cytochromes. | The pH dependence of resonance Raman spectra were studied for ferrous and ferric cytochromes c, c2, c3, c-551, and c-555. The frequencies of the 1565 cm-1 (ferric) and 1539 cm-1 lines (ferrous) were sensitive to the replacement of the sixth ligand. The titration curve for the 1565 cm-1 line of cytochrome c was parallel... | The pH dependence of the resonance raman spectra and structural alterations at heme moieties of various c-type cytochromes. The pH dependence of resonance Raman spectra were studied for ferrous and ferric cytochromes c, c2, c3, c-551, and c-555. The frequencies of the 1565 cm-1 (ferric) and 1539 cm-1 lines (ferrous) we... | [
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PMID:20153 | Nuclear magnetic resonance studies of the denaturation of ubiquitin. | The effects of pH, temperature and guanidine hydrochloride concentration on the structure of ubiquitin, a polypeptide which can activate adenylate cyclase and can mimic thymopoietin induced differentiation of prothymocytes, were monitored using nuclear magnetic resonance spectroscopy. This relatively small polypeptide ... | Nuclear magnetic resonance studies of the denaturation of ubiquitin. The effects of pH, temperature and guanidine hydrochloride concentration on the structure of ubiquitin, a polypeptide which can activate adenylate cyclase and can mimic thymopoietin induced differentiation of prothymocytes, were monitored using nuclea... | [
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PMID:20154 | The binding of calcium to fibrinogen: some structural features. | Experiments are described which suggest that structural features are related to the existence of three high affinity calcium-binding sites in the fibrinogen molecule. The circular dichroism spectra analysis shows that the binding of calcium to this protein does not entail an overall conformational change. However sever... | The binding of calcium to fibrinogen: some structural features. Experiments are described which suggest that structural features are related to the existence of three high affinity calcium-binding sites in the fibrinogen molecule. The circular dichroism spectra analysis shows that the binding of calcium to this protein... | [
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PMID:20155 | Physicochemical evidence for the existence of two pyridoxal 5'-phosphate binding sites on glutamate dehydrogenase and characterization of their functional role. | Kinetic studies of pyridoxal 5'-phosphate binding to glutamate dehydrogenase (EC 1.4.1.3) has provided evidence for two specific binding sites, chemically identified as Lys 126 and Lys 333. Use of protecting ligands permitted the selective modification of only one of these lysines, and showed that (1) Lys 333 modificat... | Physicochemical evidence for the existence of two pyridoxal 5'-phosphate binding sites on glutamate dehydrogenase and characterization of their functional role. Kinetic studies of pyridoxal 5'-phosphate binding to glutamate dehydrogenase (EC 1.4.1.3) has provided evidence for two specific binding sites, chemically iden... | [
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PMID:20157 | The isolation and characterization of a colony stimulating factor from human lung. | Serum-free conditioned medium from human lung obtained at autopsy provides a rich source of colony stimulating factor which stimulates granulocytic and macrophagic colony growth in both mouse and human bone marrow. The appearance of the factor is enhanced by endotoxin and inhibited by either puromycin or actinomycin D.... | The isolation and characterization of a colony stimulating factor from human lung. Serum-free conditioned medium from human lung obtained at autopsy provides a rich source of colony stimulating factor which stimulates granulocytic and macrophagic colony growth in both mouse and human bone marrow. The appearance of the ... | [
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PMID:20161 | [Analysis of the activity of Micrococcus luteus endonucleases with respect to gamma-irradiated DNA]. | Endonucleases from Micrococcus luteus that induce single-strand breaks in gamma-irradiated DNA have been separated chromatographycally into two groups. The first group involves two different enzymes: AP-endonuclease II (mol. weight 30 000) and AP, UV-endonuclease I (mol. weight 15 000) that recognize alkali-labile lesi... | [Analysis of the activity of Micrococcus luteus endonucleases with respect to gamma-irradiated DNA]. Endonucleases from Micrococcus luteus that induce single-strand breaks in gamma-irradiated DNA have been separated chromatographycally into two groups. The first group involves two different enzymes: AP-endonuclease II ... | [
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PMID:20162 | [Properties of human creatine kinase isoenzymes]. | Properties of human creatine kinase isoenzymes (MM, MB and BB) are investigated. The most pronounced differences in properties of these isoenzymes are found under their urea inactivation, heat denaturation and the inhibition by rabbit antisera to isoenzymes. Differences in values of the Mikhaelis constant and substrate... | [Properties of human creatine kinase isoenzymes]. Properties of human creatine kinase isoenzymes (MM, MB and BB) are investigated. The most pronounced differences in properties of these isoenzymes are found under their urea inactivation, heat denaturation and the inhibition by rabbit antisera to isoenzymes. Differences... | [
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PMID:20163 | [Soluble high molecular weight derivatives of trypsin pancreatic inhibitor. Isolation and properties of dextran-bound pancreatic inhibitor]. | A method of isolating preparations of pancreatic inhibitor of trypsin, bound with soluble polysaccharide carriers, is worked out. It is demonstrated that the reaction of a pancreatic inhibitor and cyanuric chloride-activated dextran proceeds for OH groups of tyrosine residues and for-epsilon-NH2 groups of lysine residu... | [Soluble high molecular weight derivatives of trypsin pancreatic inhibitor. Isolation and properties of dextran-bound pancreatic inhibitor]. A method of isolating preparations of pancreatic inhibitor of trypsin, bound with soluble polysaccharide carriers, is worked out. It is demonstrated that the reaction of a pancrea... | [
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PMID:20164 | [Comparative kinetic studies of Mg2+-activated hydrolysis of tripolyphosphate and pyrophosphate by inorganic pyrophosphatase]. | Computer analysis of P3 and pyrophosphate conversion rate dependence on substrate and metal-activator concentrations reveals the identity of kinetic patterns. Dissociation and catalytical constants for the enzyme combinations with two types of metal-substrates complexes, MS and M2S, at pH 9.0 are by one to two orders o... | [Comparative kinetic studies of Mg2+-activated hydrolysis of tripolyphosphate and pyrophosphate by inorganic pyrophosphatase]. Computer analysis of P3 and pyrophosphate conversion rate dependence on substrate and metal-activator concentrations reveals the identity of kinetic patterns. Dissociation and catalytical const... | [
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PMID:20160 | [Localization of unpaired electrons in molecules of the substrate inhibitors of lysozyme. II. Oligosaccharides]. | It has been shown by the method of electron photosensitized transfer that N-acetyl group is the main electron-acceptor group in oligomeres of N-acetyl glucose amine (AGA). In n-AGA molecules (n-3.5) interacting with an electron radical products of the breakage of glycoside bond are observed, their concentration rising ... | [Localization of unpaired electrons in molecules of the substrate inhibitors of lysozyme. II. Oligosaccharides]. It has been shown by the method of electron photosensitized transfer that N-acetyl group is the main electron-acceptor group in oligomeres of N-acetyl glucose amine (AGA). In n-AGA molecules (n-3.5) interact... | [
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PMID:20165 | [Solubilization and reconstruction of microsomal AMP-deaminase from skeletal muscles]. | Microsomal AMP-deaminase was solubilized by 0.5 M KCl after treatment of microsomal membranes with 0.12 M KCl. Using disc-electrophoresis in polyacrylamide gel in the presence of sodium dodecyl sulfate one major protein component (mol. weight about 90 000) and three minor ones with molecular weights of 110 000, 80 000,... | [Solubilization and reconstruction of microsomal AMP-deaminase from skeletal muscles]. Microsomal AMP-deaminase was solubilized by 0.5 M KCl after treatment of microsomal membranes with 0.12 M KCl. Using disc-electrophoresis in polyacrylamide gel in the presence of sodium dodecyl sulfate one major protein component (mo... | [
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PMID:20166 | [Purification and properties of NADP-reductase of phototropic bacteria Thiocapsa roseopersicina]. | The method of purification up to homogenous states and properties of NADP-reductase of purple bacteria Thiocapsa roseopersicina, strain BBS, are described. The molecular weight of NADP-reductase is about 47 000; it is flavoprotein consisting of two subunits. Atebrim and chloromercury bensoate inhibit the activity of NA... | [Purification and properties of NADP-reductase of phototropic bacteria Thiocapsa roseopersicina]. The method of purification up to homogenous states and properties of NADP-reductase of purple bacteria Thiocapsa roseopersicina, strain BBS, are described. The molecular weight of NADP-reductase is about 47 000; it is flav... | [
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PMID:20167 | [Free radical peroxidation of liver mitochondrial and microsomal phospholipids in rat postnatal development]. | Activities of both non-enzymic (ascorbate-dependent) and enzymic NADPH-dependent) peroxidation of microsomal and mitochondrial phospholipids are found to be increased in rat liver during postnatal development. It is suggested, that microsomal NADPH-dependent phospholipid dioxygenase forming a chemical modification of m... | [Free radical peroxidation of liver mitochondrial and microsomal phospholipids in rat postnatal development]. Activities of both non-enzymic (ascorbate-dependent) and enzymic NADPH-dependent) peroxidation of microsomal and mitochondrial phospholipids are found to be increased in rat liver during postnatal development. ... | [
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PMID:20168 | [Some features of cyclic adenosine monophosphate metabolism in mouse liver and hepatoma 22]. | The levels of cyclic adenosine monophosphate (cAMP) and two forms of cAMP phosphodiesterase with low (PDE1) and high (PDE2) affinity for the substrate were determined in homogenates from mouse liver and transplanted hepatoma 22. The level of cAMP in the tumour is 3 times lower than that in liver. By te kinetic paramete... | [Some features of cyclic adenosine monophosphate metabolism in mouse liver and hepatoma 22]. The levels of cyclic adenosine monophosphate (cAMP) and two forms of cAMP phosphodiesterase with low (PDE1) and high (PDE2) affinity for the substrate were determined in homogenates from mouse liver and transplanted hepatoma 22... | [
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PMID:20169 | Comparison of postnatal development of several acid glycosidases in the rat forebrain and cerebellum. | Changes of activity of several glycosidases (beta-galactosidase, beta-glucuronidase, N-acetyl-beta-D-glucosaminidase, alpha-D-mannosidase and alpha-L-fucosidase) were compared in the forebrain and cerebellum during postnatal development of the rat. Detailed analysis of the data showed similarities, but also substantial... | Comparison of postnatal development of several acid glycosidases in the rat forebrain and cerebellum. Changes of activity of several glycosidases (beta-galactosidase, beta-glucuronidase, N-acetyl-beta-D-glucosaminidase, alpha-D-mannosidase and alpha-L-fucosidase) were compared in the forebrain and cerebellum during pos... | [
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PMID:20170 | Dissociation of growth hormone and prolactin response to levodopa during pyridoxine administration. | 500 mg of levodopa was administered orally to 8 normal subjects and induced an increase of growth hormone (GH) and a decrease of prolactin (PRL) secretion. The levodopa-induced GH release was inhibited by an intravenous infusion of pyridoxine; on the contrary, the PRL response to levodopa was enhanced by pyridoxine inf... | Dissociation of growth hormone and prolactin response to levodopa during pyridoxine administration. 500 mg of levodopa was administered orally to 8 normal subjects and induced an increase of growth hormone (GH) and a decrease of prolactin (PRL) secretion. The levodopa-induced GH release was inhibited by an intravenous ... | [
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PMID:20171 | Isoelectric focusing of interacting systems. I. Carrier ampholyte-induced macromolecular isomerization. | A phenomenological theory of isoelectric focusing is formulated for rapidly reversible, ampholyte-induced macromolecular isomerization. The calculations reveal that such interactions can give well resolved, bimodal transient and equilibrium isoelectric focusing patterns in which the two peaks correspond to different ch... | Isoelectric focusing of interacting systems. I. Carrier ampholyte-induced macromolecular isomerization. A phenomenological theory of isoelectric focusing is formulated for rapidly reversible, ampholyte-induced macromolecular isomerization. The calculations reveal that such interactions can give well resolved, bimodal t... | [
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PMID:20172 | Isoelectric focusing of interacting systems. II. pH-dependent conformational transitions. | Transient and equilibrium isoelectric focusing patterns have been computed for pH-dependent conformational transitions in the limits of complete cooperativity and instantaneous chemical equilibration. Transitions induced by the binding of a relatively large number of hydrogen ions by the macromolecule give well resolve... | Isoelectric focusing of interacting systems. II. pH-dependent conformational transitions. Transient and equilibrium isoelectric focusing patterns have been computed for pH-dependent conformational transitions in the limits of complete cooperativity and instantaneous chemical equilibration. Transitions induced by the bi... | [
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PMID:20173 | Rheology of fibrin clots. IV. Darcy constants and fiber thickness. | Measurements of small oscillatory deformations of a fibrin clot by axial motion of a rod in a closed tube reveal an anomalous mechanical loss due to permeation of fluid through the clot structure. The Darcy constant for permeation can be calculated from data at the frequency where the apparent storage and loss shear mo... | Rheology of fibrin clots. IV. Darcy constants and fiber thickness. Measurements of small oscillatory deformations of a fibrin clot by axial motion of a rod in a closed tube reveal an anomalous mechanical loss due to permeation of fluid through the clot structure. The Darcy constant for permeation can be calculated from... | [
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PMID:20174 | The CO and NO Bohr effect of human hemoglobin with and without inositolhexaphosphate. | Using NO and CO as ligands the Bohr effect of human hemoglobin has been measured with and without inositolhexophosphate. It appears that in the absence and presence of inositolhexaphosphate hemoglobin shows a distinct ligand specificity with respect to the Bohr effect. Ligation with NO is accompanied by release of a la... | The CO and NO Bohr effect of human hemoglobin with and without inositolhexaphosphate. Using NO and CO as ligands the Bohr effect of human hemoglobin has been measured with and without inositolhexophosphate. It appears that in the absence and presence of inositolhexaphosphate hemoglobin shows a distinct ligand specifici... | [
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PMID:20175 | 1H Nmr studies at 360 MHz of the methyl groups in native and chemically modified basic pancreatic trypsin inhibitor (BPTI). | In the 1H NMR spectra obtained at 360 MHz after digital resolution enhancement, the multiplet resonances of the methyl groups in the basic pancreatic trypsin inhibitor (BPTI) were resolved. With suitable double irradiation techniques the individual methyl resonances were assigned to the different types of aliphatic ami... | 1H Nmr studies at 360 MHz of the methyl groups in native and chemically modified basic pancreatic trypsin inhibitor (BPTI). In the 1H NMR spectra obtained at 360 MHz after digital resolution enhancement, the multiplet resonances of the methyl groups in the basic pancreatic trypsin inhibitor (BPTI) were resolved. With s... | [
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PMID:20178 | Compartmentalization in proteinoid microspheres. | Proteinoid microspheres with stable internal compartments and internal structure are made from acidic proteinoid and basic proteinoid with calcium. The populations of microspheres are characterized by a wide diversity of structure. A model of primitive intracellular communication is suggested by the observed movement o... | Compartmentalization in proteinoid microspheres. Proteinoid microspheres with stable internal compartments and internal structure are made from acidic proteinoid and basic proteinoid with calcium. The populations of microspheres are characterized by a wide diversity of structure. A model of primitive intracellular comm... | [
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PMID:20180 | Life on Mars? The Viking labeled release experiment. | Viking radiorespirometry ("Labeled Release" [LR]) experiments conducted on surface material obtained at two sites on Mars have produced results which on Earth would clearly establish the presence of microbial activity in the soil. However, two factors on Mars keep the question open. First, the intense UV flux striking ... | Life on Mars? The Viking labeled release experiment. Viking radiorespirometry ("Labeled Release" [LR]) experiments conducted on surface material obtained at two sites on Mars have produced results which on Earth would clearly establish the presence of microbial activity in the soil. However, two factors on Mars keep th... | [
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0.022... |
PMID:20181 | A possible prebiotic synthesis of thymine: uracil-formaldehyde-formic acid reaction. | When uracil is reacted with formaldehyde and formic acid in dilute aqueous solutions at 100-140 degrees C, 5-hydroxymethyluracil (5-HMU), methylenebiuracil (MBU) and thymine are formed. It has been shown that 5-HMU is an intermediate in the formation of MBU and thymine. In the presence of formic acid, 5-HMU gives MBU, ... | A possible prebiotic synthesis of thymine: uracil-formaldehyde-formic acid reaction. When uracil is reacted with formaldehyde and formic acid in dilute aqueous solutions at 100-140 degrees C, 5-hydroxymethyluracil (5-HMU), methylenebiuracil (MBU) and thymine are formed. It has been shown that 5-HMU is an intermediate i... | [
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PMID:20182 | Chemical evolution XXIX. Pyrimidines from hydrogen cyanide. | Dilute (0.1 M) solutions of HCN condense to oligomers at pH 8-9. Hydrolysis of these oligomers at pH 8.5 or with 6 N HCl yields 4,5-dihydroxypyrimidine, as the most abundant pyrimidine product along with orotic acid and 5-hydroxyuracil. These results, together with the earlier data, demonstrate that the three major nit... | Chemical evolution XXIX. Pyrimidines from hydrogen cyanide. Dilute (0.1 M) solutions of HCN condense to oligomers at pH 8-9. Hydrolysis of these oligomers at pH 8.5 or with 6 N HCl yields 4,5-dihydroxypyrimidine, as the most abundant pyrimidine product along with orotic acid and 5-hydroxyuracil. These results, together... | [
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PMID:20183 | The mechanism of clay catalyzed polymerization of amino acid adenylates. | Amino acid adenylates were adsorbed on montmorillonite when either the interspatial faces or the edges of the latter were blocked. By this method it could be observed that adsorption of the amino acid adenylates takes place mostly on the planes of the clay. However, for polymerization to take place, the edges of the cl... | The mechanism of clay catalyzed polymerization of amino acid adenylates. Amino acid adenylates were adsorbed on montmorillonite when either the interspatial faces or the edges of the latter were blocked. By this method it could be observed that adsorption of the amino acid adenylates takes place mostly on the planes of... | [
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PMID:20184 | Comparison of polymerization of ancrod and thrombin fibrin monomers. | The polymerization of thrombin and ancrod fibrin monomers was studied with a standardized technique that evaluated turbidity changes and protein incorporation into the clot. Ancrod fibrin monomers were found to polymerize more slowly and form less turbid clots (at identical protein concentrations). Changes in ionic str... | Comparison of polymerization of ancrod and thrombin fibrin monomers. The polymerization of thrombin and ancrod fibrin monomers was studied with a standardized technique that evaluated turbidity changes and protein incorporation into the clot. Ancrod fibrin monomers were found to polymerize more slowly and form less tur... | [
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PMID:20185 | Allogeneic bone marrow transplantation in conventional mice: I. Effect of antibiotic therapy on long term survival of allogeneic chimeras. | In the present communication the beneficial effect of long term antimicrobial treatment with poorly absorbable antiboitics on the survival of allogeneic bone marrow chimeras was investigated. The combination of C57Bl mice as bone marrow donors and CBA/CA mice as irradiated recipients (800 rad) was used because of their... | Allogeneic bone marrow transplantation in conventional mice: I. Effect of antibiotic therapy on long term survival of allogeneic chimeras. In the present communication the beneficial effect of long term antimicrobial treatment with poorly absorbable antiboitics on the survival of allogeneic bone marrow chimeras was inv... | [
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PMID:20187 | Acid-base response to chronic hypocapnia in man. | The acid-base values of 13 patients with stable carbon dioxide tensions under controlled ventilation have been used to define the response to chronic hypocapnia in man. These patients had a respiratory paralysis and no apparent complicating disorders. Over a range of carbon dioxide tensions from 24 to 40 millimetres of... | Acid-base response to chronic hypocapnia in man. The acid-base values of 13 patients with stable carbon dioxide tensions under controlled ventilation have been used to define the response to chronic hypocapnia in man. These patients had a respiratory paralysis and no apparent complicating disorders. Over a range of car... | [
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PMID:20191 | Effects of aspirin-like drugs on canine gastric mucosal blood flow and acid secretion. | 1. The effects of aspirin, paracetamol and benorylate were studied on gastric mucosal blood flow (MBF) and acid secretion in canine denervated gastric pouches. 2. Aspirin 20 mM in the unstimulated pouch had no effect; pentagastrin-stimulated acid output, but not MBF, was reduced. Aspirin buffered to pH 6 was ineffectiv... | Effects of aspirin-like drugs on canine gastric mucosal blood flow and acid secretion. 1. The effects of aspirin, paracetamol and benorylate were studied on gastric mucosal blood flow (MBF) and acid secretion in canine denervated gastric pouches. 2. Aspirin 20 mM in the unstimulated pouch had no effect; pentagastrin-st... | [
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PMID:20192 | The uptake and overflow of radiolabelled beta-adrenoceptor blocking agents by the isolated vas deferens of the rat. | 1. A comparison of uptake into and overflow from the isolated vas deferens of the rat has been made between [3H]-noradrenaline ([3H]-NA), [14C]-D-sorbitol and three radio-labelled beta-adrenoceptor blocking agents, [14C]-practolol, [14C]-(+/-)-propranolol and [3H]-penbutolol. 2. The accumulation of [3H]-NA after 30 min... | The uptake and overflow of radiolabelled beta-adrenoceptor blocking agents by the isolated vas deferens of the rat. 1. A comparison of uptake into and overflow from the isolated vas deferens of the rat has been made between [3H]-noradrenaline ([3H]-NA), [14C]-D-sorbitol and three radio-labelled beta-adrenoceptor blocki... | [
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PMID:20194 | Selective induction of tyrosine hydroxylase and dopamine beta-hydroxylase by nerve growth factor: comparison between adrenal medulla and sympathetic ganglia of adult and newborn rats. | Administration of NGF to newborn and adult rats elicits a selective increase in TH and DBH both in sympathetic ganglia and adrenal medulla. This effect does not depend on intact preganglionic cholinergic fibers. The augmented enzyme activity results from enhanced enzyme synthesis since it can be abolished by cyclohexim... | Selective induction of tyrosine hydroxylase and dopamine beta-hydroxylase by nerve growth factor: comparison between adrenal medulla and sympathetic ganglia of adult and newborn rats. Administration of NGF to newborn and adult rats elicits a selective increase in TH and DBH both in sympathetic ganglia and adrenal medul... | [
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PMID:20195 | Biochemical differentiation of aggregating cell cultures of different fetal rat brain regions. | Rotation-mediated aggregating cell cultures of mechanically dissociated fetal rat brains divided into three (telencephalon, mesencephalon-diencephalon and rhombencephalon), or two (telencephalon and mesencephalon-diencephalon plus rhombencephalon) parts were examined for their biochemical differentiation by measuring t... | Biochemical differentiation of aggregating cell cultures of different fetal rat brain regions. Rotation-mediated aggregating cell cultures of mechanically dissociated fetal rat brains divided into three (telencephalon, mesencephalon-diencephalon and rhombencephalon), or two (telencephalon and mesencephalon-diencephalon... | [
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PMID:20197 | The importance of Lactobacilli in maintaining normal microbial balance in the crop. | 1. The effect of lactobacilli on Escherichia coli has been examined in vitro and in chicken crop in vivo. 2. Inhibition of E. coli was dependent on the presence of sufficient numbers of lactobacilli. 3. In a standard test some lactobacilli were bacteriostatic and one was bactericidal. The bacteriostasis was due to the ... | The importance of Lactobacilli in maintaining normal microbial balance in the crop. 1. The effect of lactobacilli on Escherichia coli has been examined in vitro and in chicken crop in vivo. 2. Inhibition of E. coli was dependent on the presence of sufficient numbers of lactobacilli. 3. In a standard test some lactobaci... | [
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PMID:20198 | [Actions of sodium dichloroacetate in combination with insulin on hyperlactatemia and hyperpyruvicemia induced in dogs by phenformin]. | In the normal anesthetized dog the combination of insulin, whether of exogenous or endogenous origin, with sodium dichloroacetate provoke a rapid and important reduction of the hyperlactatemia and hyperpyruvicemia induced by the intraduodenal injection of high doses of phenformin. Furthermore this combination prevents ... | [Actions of sodium dichloroacetate in combination with insulin on hyperlactatemia and hyperpyruvicemia induced in dogs by phenformin]. In the normal anesthetized dog the combination of insulin, whether of exogenous or endogenous origin, with sodium dichloroacetate provoke a rapid and important reduction of the hyperlac... | [
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PMID:20199 | [Effects of a beta-adrenolytic and a diuretic vis-à-vis hyper-reninemia induced by isoprenaline in anesthetized dogs. Value of beta blocking-diuretic interaction]. | Intravenous injection of isoproterenol increases plasma renin activity (PRA) in anesthetized dogs. S. 464, a new beta adrenergic blocking agent, injected five minutes before isoproterenol, inhibits plasma renin hyperactivity. On the other hand, teclothiazide, a thiazide diuretic, induces no significant modification of ... | [Effects of a beta-adrenolytic and a diuretic vis-à-vis hyper-reninemia induced by isoprenaline in anesthetized dogs. Value of beta blocking-diuretic interaction]. Intravenous injection of isoproterenol increases plasma renin activity (PRA) in anesthetized dogs. S. 464, a new beta adrenergic blocking agent, injected fi... | [
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PMID:20200 | [Action of 3-beta adrenolytics on plasma renin activity measured by radioimmunology in genetically hypertensive rats]. | Spontaneously hypertensive rats (SHR) have basal levels of plasma renin activity (PRA) lower than the ones observed in normal Sprague Dawley rats. Three beta blocking agents are orally administered to unanesthetized spontaneously hypertensive and normotensive rats. Propranolol and S 464 reduce PRA in spontaneously hype... | [Action of 3-beta adrenolytics on plasma renin activity measured by radioimmunology in genetically hypertensive rats]. Spontaneously hypertensive rats (SHR) have basal levels of plasma renin activity (PRA) lower than the ones observed in normal Sprague Dawley rats. Three beta blocking agents are orally administered to ... | [
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PMID:20202 | [Partial disorganization of the anaphasic segregation of chromosomes in plant cells: combined actions of griseofulvin, producer of pluripolar anaphases and 2 ipecac alkaloids, producers of floating pole anaphases]. | Anaphasis may be slightly checked by various treatments which however result in a normal chromosomic separation. Griseofulvin exerts a direct though partial influence on the mitotic apparatus, which entails "pluripolar anaphasis"; on the other hand Ipecac alkaloïds act indirectly and produce "floating poles anaphases".... | [Partial disorganization of the anaphasic segregation of chromosomes in plant cells: combined actions of griseofulvin, producer of pluripolar anaphases and 2 ipecac alkaloids, producers of floating pole anaphases]. Anaphasis may be slightly checked by various treatments which however result in a normal chromosomic sepa... | [
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PMID:20205 | Peripheral vascular and cardiac effects of nitrous oxide in the bovine. | Peripheral vascular and myocardial effects of increasing concentrations of nitrous oxide (0 to 70 per cent) in oxygen were determined in 15 unanaesthetized calves before and after replacement in their natural heart (NH) with a pneumatically driven artificial heart (AH). Nitrous oxide produced concentration-related decr... | Peripheral vascular and cardiac effects of nitrous oxide in the bovine. Peripheral vascular and myocardial effects of increasing concentrations of nitrous oxide (0 to 70 per cent) in oxygen were determined in 15 unanaesthetized calves before and after replacement in their natural heart (NH) with a pneumatically driven ... | [
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PMID:20206 | Purification and partial characterization of an exo-beta-glucanase from the yeast Kluyveromyces aestaurii. | The intracellular-periplasmic exo-1,3-beta-glucanase (EC 3.2.1.58) has been extracted from the yeast Kluyveromyces aestuarii and purified to immunoelectrophoretic homogeneity by ion-exchange and gel-exclusion chromatography. The kinetic constants and activation energies for laminarin, p-nitrophenyl-beta-D-glucoside, an... | Purification and partial characterization of an exo-beta-glucanase from the yeast Kluyveromyces aestaurii. The intracellular-periplasmic exo-1,3-beta-glucanase (EC 3.2.1.58) has been extracted from the yeast Kluyveromyces aestuarii and purified to immunoelectrophoretic homogeneity by ion-exchange and gel-exclusion chro... | [
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PMID:20207 | The role of divalent cations in the activation of the NADP+-specific isocitrate dehydrogenase from Pisum sativum L. | A divalent cation electrode was used to measure the stability constants (association constants) for the magnesium and manganese complexes of the substrates for the NADP+-specific isocitrate dehydrogenase (EC 1.1.1.42) from pea stems. At an ionic strength of 26.5 mM and at pH 7.4 the stability constants for the Mg2+-iso... | The role of divalent cations in the activation of the NADP+-specific isocitrate dehydrogenase from Pisum sativum L. A divalent cation electrode was used to measure the stability constants (association constants) for the magnesium and manganese complexes of the substrates for the NADP+-specific isocitrate dehydrogenase ... | [
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PMID:20208 | The interaction of human glycophorin with 8-anilino-1-naphthalene sulfonate. | Both the sialoglycoprotein of human erythrocyte membranes, glycophorin, and the sialic acid free protein, obtained by treatment of glycophorin with neuraminidase (EC 3.2.1.18), increase the fluorescence of 8-anilino-1-naphthalene sulfonate (ANS). Binding of ANS to glycophorin is weak compared with the binding to bovine... | The interaction of human glycophorin with 8-anilino-1-naphthalene sulfonate. Both the sialoglycoprotein of human erythrocyte membranes, glycophorin, and the sialic acid free protein, obtained by treatment of glycophorin with neuraminidase (EC 3.2.1.18), increase the fluorescence of 8-anilino-1-naphthalene sulfonate (AN... | [
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PMID:20209 | Purification and partial characterization of cysteine-glutamate transaminase from rat liver. | Cysteine-glutamate transaminase (cysteine aminotransferase; EC 2.6.1.3) has been purified 149-fold to an apparent homogeneity giving a specific activity of 2.09 IU per milligram of protein with an overall yield of 15%. The isolation procedures involve the preliminary separation of a crude rat liver homogenate which was... | Purification and partial characterization of cysteine-glutamate transaminase from rat liver. Cysteine-glutamate transaminase (cysteine aminotransferase; EC 2.6.1.3) has been purified 149-fold to an apparent homogeneity giving a specific activity of 2.09 IU per milligram of protein with an overall yield of 15%. The isol... | [
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PMID:20210 | Electrolyte levels and net fluid and electrolyte movements in the gastrointestinal tract of weanling swine. | Electrolyte concentrations, osmolality and pH were determined in conventionally raised weanling swine fed a liquid diet. Incorporation of a dilution marker into the diet in combination with frequent feeding enabled estimations as to the sites of relative fluid and electrolyte absorption and secretion along the gastroin... | Electrolyte levels and net fluid and electrolyte movements in the gastrointestinal tract of weanling swine. Electrolyte concentrations, osmolality and pH were determined in conventionally raised weanling swine fed a liquid diet. Incorporation of a dilution marker into the diet in combination with frequent feeding enabl... | [
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PMID:20211 | Studies on the antigenicity of an inactivated, aluminum hydroxide adjuvant equine influenza vaccine. | An inactivated, aluminum hydroxide adjuvant equine influenza vaccine was tested in horses and guinea pigs to determine the levels of antigen that would elicit maximum serological responses. Vaccine containing serial twofold increments of A/Equi-1/Prague and A/Equi-2/Miami strains of equine influenza virus was administe... | Studies on the antigenicity of an inactivated, aluminum hydroxide adjuvant equine influenza vaccine. An inactivated, aluminum hydroxide adjuvant equine influenza vaccine was tested in horses and guinea pigs to determine the levels of antigen that would elicit maximum serological responses. Vaccine containing serial two... | [
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PMID:20212 | Proximal-distal absorptive gradients in the in vivo intestine of normal and infected (Hymenolepis diminuta: Cestoda) rats. | Using a single-pass perfusion technique, H2O, Na+, Cl-, HCO3-, and glucose absorption were studied in the jejunum and proximal and distal ileum of rats either uninfected or infected with a tapeworm parasite (Hymenolepis diminuta). The effect of parasitization, region of the intestine, type of buffer, and concentration ... | Proximal-distal absorptive gradients in the in vivo intestine of normal and infected (Hymenolepis diminuta: Cestoda) rats. Using a single-pass perfusion technique, H2O, Na+, Cl-, HCO3-, and glucose absorption were studied in the jejunum and proximal and distal ileum of rats either uninfected or infected with a tapeworm... | [
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PMID:20213 | Influence of cold exposure and thyroid hormones on regulation of adrenal catecholamines. | Since thyroid hormones influence urinary excretion of catecholamines after exposure to cold, the effects of hyper- and hypo-thyroidism on adrenal tyrosine hydroxylase (TH) (EC 1.14.16.2), phenylethanolamine-N-methyl transferase (PNMT) (EC 2.1.1.28), and serum dopamine-beta-hydroxylase (DbetaH) (EC 1.14.17.1) of rats of... | Influence of cold exposure and thyroid hormones on regulation of adrenal catecholamines. Since thyroid hormones influence urinary excretion of catecholamines after exposure to cold, the effects of hyper- and hypo-thyroidism on adrenal tyrosine hydroxylase (TH) (EC 1.14.16.2), phenylethanolamine-N-methyl transferase (PN... | [
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PMID:20216 | The catabolism of L-tyrosine by an Arthrobacter sp. | An Arthrobacter sp. metabolizes L-tyrosine by a pathway involving 3,4-dihydroxyphenylacetate as a key intermediate. p-Hydroxyphenylpyruvate is formed from tyrosine by an amino-transferase specifically requiring alpha-ketoglutarate for activity, and is then converted to p-hydroxyphenylacetate by an oxidative decarboxyla... | The catabolism of L-tyrosine by an Arthrobacter sp. An Arthrobacter sp. metabolizes L-tyrosine by a pathway involving 3,4-dihydroxyphenylacetate as a key intermediate. p-Hydroxyphenylpyruvate is formed from tyrosine by an amino-transferase specifically requiring alpha-ketoglutarate for activity, and is then converted t... | [
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PMID:20217 | The cellulase system of a Cytophaga species. | Cellulases (EC 3.2.1.4) of a Cytophaga species WTHC 2421 (ATCC 29474) were found in the soluble portion of the cell (the periplasm and the cytoplasm) and on the membrane. Cell-free cellulases were not found. Most of the carboxymethylcellulase activity associated with reduction of viscosity was membrane bound, whereas m... | The cellulase system of a Cytophaga species. Cellulases (EC 3.2.1.4) of a Cytophaga species WTHC 2421 (ATCC 29474) were found in the soluble portion of the cell (the periplasm and the cytoplasm) and on the membrane. Cell-free cellulases were not found. Most of the carboxymethylcellulase activity associated with reducti... | [
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PMID:20218 | The role of 6-phosphogluconate dehydrogenase in Rhizobium. | A nicotinamide adenine dinucleotide (NAD) linked 6-phosphogluconate (6-PG)dehydrogenase has been detected in Rhizobium. The enzyme activity is similar in both slow- and fast-growing rhizobia. The nicotinamide adenine dinucleotide phosphate (NADP) dependent 6-PG dehydrogenase was detected only in the fast growers and wa... | The role of 6-phosphogluconate dehydrogenase in Rhizobium. A nicotinamide adenine dinucleotide (NAD) linked 6-phosphogluconate (6-PG)dehydrogenase has been detected in Rhizobium. The enzyme activity is similar in both slow- and fast-growing rhizobia. The nicotinamide adenine dinucleotide phosphate (NADP) dependent 6-PG... | [
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PMID:20219 | Glycogen synthesis by amylosucrase from Neisseria perflava. | Amylosucrase (sucrose:1,4-alpha-D-glucan 4-alpha-glucosyltransferase; EC 2.4.1.4) which mediates the transfer of the glucosyl moiety of sucrose to a growing alpha-1,4-glucan chain is a constitutive enzyme of Neisseria perflava. The products of enzymic action are insoluble glycogenlike polysaccharides and fructose, the ... | Glycogen synthesis by amylosucrase from Neisseria perflava. Amylosucrase (sucrose:1,4-alpha-D-glucan 4-alpha-glucosyltransferase; EC 2.4.1.4) which mediates the transfer of the glucosyl moiety of sucrose to a growing alpha-1,4-glucan chain is a constitutive enzyme of Neisseria perflava. The products of enzymic action a... | [
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PMID:20223 | Further development of a successful protocol of graft versus leukemia without fatal graft-versus-host disease in AKR mice. | We previously reported a successful model for treatment of BW 5147 leukemia in AKR mice by adoptive immunotherapy using allogeneic spleen cells from C57BL/6 mice. The leukemia cells were given 3 days before initiation of therapy. Graft-versus-host reaction was prevented by treatment with spleen cells from a second allo... | Further development of a successful protocol of graft versus leukemia without fatal graft-versus-host disease in AKR mice. We previously reported a successful model for treatment of BW 5147 leukemia in AKR mice by adoptive immunotherapy using allogeneic spleen cells from C57BL/6 mice. The leukemia cells were given 3 da... | [
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... |
PMID:20226 | Glucocorticoid receptors in Morris hepatomas and host liver and the correlation of biological activity with receptor levels. | Glucocorticoid-binding macromolecules were examined in Morris hepatomas 7787, 5123tc, 3683F, 7800, and 3683 and the Reuber hepatoma H-35 with the use of the synthetic glucocorticoid, triamcinolone acetonide. The physical properties of the triamcinolone acetonide-binding macromolecules of the hepatomas indicate that the... | Glucocorticoid receptors in Morris hepatomas and host liver and the correlation of biological activity with receptor levels. Glucocorticoid-binding macromolecules were examined in Morris hepatomas 7787, 5123tc, 3683F, 7800, and 3683 and the Reuber hepatoma H-35 with the use of the synthetic glucocorticoid, triamcinolon... | [
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0.0343581959605217,
0.0033133579418063164,
0.029414014890789986,
0.033806... |
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