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PMID:20445 | Mast cell binding of neurotensin. I. Iodination of neurotensin and characterization of the interaction of neurotensin with mast cell receptor sites. | Neurotensin was iodinated at equimolar concentrations of peptide, iodide, and chloramine-T, producing a labeled peptide with a specific activity of 1000 to 2000 Ci/mmol. Rat mast cells specifically and reversibly bound 1.27 pmol of neurotensin/10(6) cells with a reversible affinity, KD, of 154 nM. Optimum specific bind... | Mast cell binding of neurotensin. I. Iodination of neurotensin and characterization of the interaction of neurotensin with mast cell receptor sites. Neurotensin was iodinated at equimolar concentrations of peptide, iodide, and chloramine-T, producing a labeled peptide with a specific activity of 1000 to 2000 Ci/mmol. R... | [
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PMID:20446 | RNA polymerase activity in bovine spermatozoa. | Washed mature spermatozoa from bulls incorporate ribonucleoside triphosphates into RNA using an endogenous template. Maximum incorporation was observed at 31 degrees C in the presence of MgCl2, all four ribonucleoside triphosphates, beta-mercaptoethanol, and glycine sodium hydroxide buffer at pH 9.0. The amount of synt... | RNA polymerase activity in bovine spermatozoa. Washed mature spermatozoa from bulls incorporate ribonucleoside triphosphates into RNA using an endogenous template. Maximum incorporation was observed at 31 degrees C in the presence of MgCl2, all four ribonucleoside triphosphates, beta-mercaptoethanol, and glycine sodium... | [
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PMID:20447 | The contractile basis of amoeboid movement. V. The control of gelation, solation, and contraction in extracts from Dictyostelium discoideum. | Motile extracts have been prepared from Dictyostelium discoideum by homogenization and differential centrifugation at 4 degrees C in a stabilization solution (60). These extracts gelled on warming to 25 degrees Celsius and contracted in response to micromolar Ca++ or a pH in excess of 7.0. Optimal gelation occurred in ... | The contractile basis of amoeboid movement. V. The control of gelation, solation, and contraction in extracts from Dictyostelium discoideum. Motile extracts have been prepared from Dictyostelium discoideum by homogenization and differential centrifugation at 4 degrees C in a stabilization solution (60). These extracts ... | [
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PMID:20448 | The stability of tyrosine aminotransferase and other proteins in enucleated rat hepatoma tissue culture cells. | The role of the nucleus in bringing about the induction of tyrosine aminotransferase (TAT) by glucocorticosteroid hormone and its deinduction upon steroid removal has been studied in enucleated rat hepatoma tissue culture cells (FU5-5). Both processes require the presence of the nucleus. However, cytoplasts from preind... | The stability of tyrosine aminotransferase and other proteins in enucleated rat hepatoma tissue culture cells. The role of the nucleus in bringing about the induction of tyrosine aminotransferase (TAT) by glucocorticosteroid hormone and its deinduction upon steroid removal has been studied in enucleated rat hepatoma ti... | [
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PMID:20450 | Initiation of human parturition. VI. Identification and quantification of progesterone metabolites produced by the components of human fetal membranes. | The fetal membranes play a central role in the initiation of human parturition, a role that may be subserved in part by quantitative changes in progesterone metabolism. In order to identify and to quantify the metabolites of progesterone produced by the components of the human fetal membranes, amnion and chorion laeve ... | Initiation of human parturition. VI. Identification and quantification of progesterone metabolites produced by the components of human fetal membranes. The fetal membranes play a central role in the initiation of human parturition, a role that may be subserved in part by quantitative changes in progesterone metabolism.... | [
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PMID:20452 | Chromatographic separations of alphavirus strains by hydroxylapatite. | Hydroxylapatite column chromatography methods were developed to characterize selected alphavirus populations. Different conditions of pH and phosphate molarity were required to obtain satisfactory elution profiles and separations for Western equine encephalomyelitis virus strains, compared with Eastern equine encephalo... | Chromatographic separations of alphavirus strains by hydroxylapatite. Hydroxylapatite column chromatography methods were developed to characterize selected alphavirus populations. Different conditions of pH and phosphate molarity were required to obtain satisfactory elution profiles and separations for Western equine e... | [
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PMID:20453 | Sonication as a tool for the study of adenylyl cyclase activity. | The technique of sonication was applied in studying adenylyl cyclase activity of cultured fibroblasts. Exposure of BHK 21 c/13 to brief periods of low power sonication gives cell preparations with greater basal, fluoride and hormone sensitive adenylyl cyclase activites than those of broken cell preparations of homogeni... | Sonication as a tool for the study of adenylyl cyclase activity. The technique of sonication was applied in studying adenylyl cyclase activity of cultured fibroblasts. Exposure of BHK 21 c/13 to brief periods of low power sonication gives cell preparations with greater basal, fluoride and hormone sensitive adenylyl cyc... | [
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PMID:20454 | Blood and tissue distribution of gamma glutamyl transferase in the cow. | To test the hepatic specificity of gamma-glutamyl transferase in the cow, the tissue distribution of this enzyme was studied in 10 healthy adult cows. It was located mainly in kidney, pancreas, and liver. The relative hepatic specificity of this enzyme indicated that measurement of its activity in serum could be a valu... | Blood and tissue distribution of gamma glutamyl transferase in the cow. To test the hepatic specificity of gamma-glutamyl transferase in the cow, the tissue distribution of this enzyme was studied in 10 healthy adult cows. It was located mainly in kidney, pancreas, and liver. The relative hepatic specificity of this en... | [
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PMID:20473 | Myxomatosis on the Western Plains of Victoria. | Myxomatosis on the Western Plains is an enzootic disease in contrast with the epizootic pattern which is general in eastern Australia. The most unusual aspects are the presence of significant numbers of diseased rabbits throughout the winter and the continuously low percentage of rabbits with antibodies to myxoma virus... | Myxomatosis on the Western Plains of Victoria. Myxomatosis on the Western Plains is an enzootic disease in contrast with the epizootic pattern which is general in eastern Australia. The most unusual aspects are the presence of significant numbers of diseased rabbits throughout the winter and the continuously low percen... | [
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PMID:20478 | Phenothiazine phototoxicity: toxic chlorpromazine photoproducts. | The effect of preirradiated chlorpromazine (CPZ) solutions has been studied in vivo in the guinea pig and in vitro in a yeast culture. With intracutaneous administration of CPZ solutions preirradiated with long-wave ultraviolet radiation (UVA), an inflammatory response was attained equaling the response achieved when n... | Phenothiazine phototoxicity: toxic chlorpromazine photoproducts. The effect of preirradiated chlorpromazine (CPZ) solutions has been studied in vivo in the guinea pig and in vitro in a yeast culture. With intracutaneous administration of CPZ solutions preirradiated with long-wave ultraviolet radiation (UVA), an inflamm... | [
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PMID:20479 | Acute bacterial meningitis at Boston City Hospital during 12 selected years, 1935-1972. | Data are presented on the occurrence of and mortality rate from acute bacterial meningitis at Boston City Hospital during 12 years between 1935 and 1972 selected in relation to the introduction of potent antibacterial agents. The most frequent causative organisms were Streptococcus pneumoniae, Neisseria meningitidis, a... | Acute bacterial meningitis at Boston City Hospital during 12 selected years, 1935-1972. Data are presented on the occurrence of and mortality rate from acute bacterial meningitis at Boston City Hospital during 12 years between 1935 and 1972 selected in relation to the introduction of potent antibacterial agents. The mo... | [
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PMID:20481 | Some properties of Hb G San Jose (beta7 glu replaced by gly): comparisons with Hb S. | Hb G San Jose (beta7 glu leads to gly) was studied with respect to oxygen affinity, Bohr effect, surface activity in dilute aqueous solutions, mechanical precipitability, heat stability and its ability to copolymerize in the deoxy form with Hb S. Oxygen affinity, Bohr effect, and polymerization with Hb S were found to ... | Some properties of Hb G San Jose (beta7 glu replaced by gly): comparisons with Hb S. Hb G San Jose (beta7 glu leads to gly) was studied with respect to oxygen affinity, Bohr effect, surface activity in dilute aqueous solutions, mechanical precipitability, heat stability and its ability to copolymerize in the deoxy form... | [
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PMID:20482 | Effect of dietary fat saturation on acylcoenzyme A:-cholesterol acyltransferase activity of Ehrlich cell microsomes. | Ehrlich cells grown in mice fed coconut oil diets (highly saturated) contain about twice as much cholesteryl ester as those grown in mice fed sunflower oil diets (highly polyunsaturated). Acylcoenzyme A: cholesterol acyltransferase (ACAT) activity was 30-100% higher in microsomes prepared from the cells grown on coconu... | Effect of dietary fat saturation on acylcoenzyme A:-cholesterol acyltransferase activity of Ehrlich cell microsomes. Ehrlich cells grown in mice fed coconut oil diets (highly saturated) contain about twice as much cholesteryl ester as those grown in mice fed sunflower oil diets (highly polyunsaturated). Acylcoenzyme A:... | [
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PMID:20483 | Effect of sodium valproate on plasma protein binding of diphenylhydantoin. | In vivo and in vitro experimental data are presented in support of the hypothesis that sodium valproate displaces diphenylhydantoin (DPH) from plasma protein binding sites. This interaction could have important practical implications in the management of patients on combined therapy with these two drugs. Acute neurolog... | Effect of sodium valproate on plasma protein binding of diphenylhydantoin. In vivo and in vitro experimental data are presented in support of the hypothesis that sodium valproate displaces diphenylhydantoin (DPH) from plasma protein binding sites. This interaction could have important practical implications in the mana... | [
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PMID:20485 | Mouse spinal cord in cell culture. III. Neuronal chemosensitivity and its relationship to synaptic activity. | 1. Mouse spinal cord (SC) cells in dissociated cell cultures showed strong electrophysiologic responses to glutamate, gamma-aminobutyric acid (GABA), and glycine when these were iontophoretically applied to the neurons. 2. The extrapolated reversal potential for the glutamate response was 20-30 mV negative in contrast ... | Mouse spinal cord in cell culture. III. Neuronal chemosensitivity and its relationship to synaptic activity. 1. Mouse spinal cord (SC) cells in dissociated cell cultures showed strong electrophysiologic responses to glutamate, gamma-aminobutyric acid (GABA), and glycine when these were iontophoretically applied to the ... | [
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PMID:20486 | Early effects of hypervitaminosis A on gluconeogenic activity and amino acid metabolizing enzymes of rat liver. | In an earlier report from this laboratory, one of the early manifestations of hypervitaminosis A was shown to be a marked stimulation of hepatic gluconeogenesis. In the present study, effects of feeding 30,000 IU of retinyl palmitate to young rats (80-100 g), once daily, for 2 days on the incorporation of 14C-labeled p... | Early effects of hypervitaminosis A on gluconeogenic activity and amino acid metabolizing enzymes of rat liver. In an earlier report from this laboratory, one of the early manifestations of hypervitaminosis A was shown to be a marked stimulation of hepatic gluconeogenesis. In the present study, effects of feeding 30,00... | [
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PMID:20487 | Sites of organic acid production and patterns of digesta movement in the gastrointestinal tract of the rock hyrax. | The rock hyrax, smallest of the present day ungulates and a near relative of the elephant, has a gastrointestinal tract of such complex nature that it may be considered ccomparable to both the simple and complex stomach mammals, and also to birds. They have a stomach to body weight capacity equal to that of sheep. But ... | Sites of organic acid production and patterns of digesta movement in the gastrointestinal tract of the rock hyrax. The rock hyrax, smallest of the present day ungulates and a near relative of the elephant, has a gastrointestinal tract of such complex nature that it may be considered ccomparable to both the simple and c... | [
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PMID:20491 | Vehicle effects on ocular drug bioavailability II: Evaluation of pilocarpine. | The influence of vehicle composition on ocular penetration of pilocarpine was studied in the albino rabbit. Increasing the pH of a vehicle promoted increased corneal penetration for pilocarpine, in accordance with the pH-partition hypothesis, but a similar series of experiments with a nonionizable drug, glycerin, gave ... | Vehicle effects on ocular drug bioavailability II: Evaluation of pilocarpine. The influence of vehicle composition on ocular penetration of pilocarpine was studied in the albino rabbit. Increasing the pH of a vehicle promoted increased corneal penetration for pilocarpine, in accordance with the pH-partition hypothesis,... | [
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PMID:20492 | Everted rat intestinal sacs as an in vitro model for assessing absorptivity of new drugs. | An in vitro model that utilizes everted rat intestinal sacs was evaluated for assessing the absorptivity of several analogs of potential drug substances prior to formulation work and clinical trials. This model not only is a useful qualitative tool for assessing absorptivity of structurally related compounds but also y... | Everted rat intestinal sacs as an in vitro model for assessing absorptivity of new drugs. An in vitro model that utilizes everted rat intestinal sacs was evaluated for assessing the absorptivity of several analogs of potential drug substances prior to formulation work and clinical trials. This model not only is a usefu... | [
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PMID:20494 | Characteristics of medicated and unmedicated microglobules recovered from complex coacervates of gelatin-acacia. | Medicated and unmedicated microglobules prepared from complex coacervates of Type A gelatin and acacia were recovered as water-insoluble powders consisting of discrete units, which were spontaneously revertible to highly disperse systems when suspended in water or physiological electrolyte solutions. Spherical microglo... | Characteristics of medicated and unmedicated microglobules recovered from complex coacervates of gelatin-acacia. Medicated and unmedicated microglobules prepared from complex coacervates of Type A gelatin and acacia were recovered as water-insoluble powders consisting of discrete units, which were spontaneously reverti... | [
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PMID:20495 | In vitro adsorption of doxorubicin hydrochloride on insoluble calcium phosphate. | The adsorption of doxorubicin hydrochloride, a potent antitumor agent, on solid tribasic calcium phosphate was studied in vitro. A Langmuir adsorption isotherm at pH 7.4 and the maximum adsorption capacity of tribasic calcium phosphate were established. Tribasic calcium phosphate was chosen as a model for solid bone sa... | In vitro adsorption of doxorubicin hydrochloride on insoluble calcium phosphate. The adsorption of doxorubicin hydrochloride, a potent antitumor agent, on solid tribasic calcium phosphate was studied in vitro. A Langmuir adsorption isotherm at pH 7.4 and the maximum adsorption capacity of tribasic calcium phosphate wer... | [
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PMID:20497 | Mechanism of isoproterenol-induced desensitization of tracheal smooth muscle. | Isolated rat tracheal smooth muscle became considerably less sensitive to the relaxing action of isoproterenol after being incubated with 5 x 10(-6) M isoproterenol for 30 minutes. Pretreatment of the tissue with propranolol, but not with methylprednisolone, clearly reduced the isoproterenol-induced desensitization. Th... | Mechanism of isoproterenol-induced desensitization of tracheal smooth muscle. Isolated rat tracheal smooth muscle became considerably less sensitive to the relaxing action of isoproterenol after being incubated with 5 x 10(-6) M isoproterenol for 30 minutes. Pretreatment of the tissue with propranolol, but not with met... | [
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PMID:20498 | Effect of dipivalyl derivatives of catecholamines on cardiovascular function in the conscious dog. | Dipivalyl derivatives of epinephrine, norepinephrine and isoproterenol were injected intravenously into conscious dogs while cardiovascular variables were monitored. The dipivalyl compounds produced cardiovascular effects that were comparable to those produced by their respective parent catecholamines except that the r... | Effect of dipivalyl derivatives of catecholamines on cardiovascular function in the conscious dog. Dipivalyl derivatives of epinephrine, norepinephrine and isoproterenol were injected intravenously into conscious dogs while cardiovascular variables were monitored. The dipivalyl compounds produced cardiovascular effects... | [
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PMID:20499 | Effect of changing the composition of the bathing solutions upon the isometric tension-pCa relationship in bundles of crustacean myofibrils. | 1. The relative isometric tension-pCa relationship has been determined for isolated bundles of barnacle myofibrils under a variety of ionic conditions using [Ca(2+)]-buffered solutions which also contained an ATP regenerating system (creatine phosphate and creatine kinase).2. The results are in better agreement with th... | Effect of changing the composition of the bathing solutions upon the isometric tension-pCa relationship in bundles of crustacean myofibrils. 1. The relative isometric tension-pCa relationship has been determined for isolated bundles of barnacle myofibrils under a variety of ionic conditions using [Ca(2+)]-buffered solu... | [
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PMID:20500 | Daily changes in the blood of conscious pigs with catheters in foetal and uterine vessels during late gestation. | 1. Catheters were inserted into the foetal carotid artery and maternal middle uterine artery and vein in twenty foetuses from fifteen sows, 91-105 days pregnant. Blood samples were collected from foetal and maternal circulations for periods of 7-21 days after surgery.2. Blood gas tensions, pH, packed cell volume (PCV) ... | Daily changes in the blood of conscious pigs with catheters in foetal and uterine vessels during late gestation. 1. Catheters were inserted into the foetal carotid artery and maternal middle uterine artery and vein in twenty foetuses from fifteen sows, 91-105 days pregnant. Blood samples were collected from foetal and ... | [
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PMID:20501 | Continuous direct measurement of intracellular chloride and pH in frog skeletal muscle. | 1. Ion-sensitive electrodes (made with a chloride-sensitive ion-exchange resin) were used to measure the internal chloride activity (a(i) (Cl)) of frog sartorius fibres at 25 degrees C.2. The internal pH (pH(i)) of other sartorius fibres was measured with a recessed tip pH-sensitive electrode (made with pH-sensitive gl... | Continuous direct measurement of intracellular chloride and pH in frog skeletal muscle. 1. Ion-sensitive electrodes (made with a chloride-sensitive ion-exchange resin) were used to measure the internal chloride activity (a(i) (Cl)) of frog sartorius fibres at 25 degrees C.2. The internal pH (pH(i)) of other sartorius f... | [
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PMID:20502 | beta-Adrenergic blocking agents. 16. 1-(Acylaminomethyl-, ureidomethyl-, and ureidoethylphenoxy)-3-amino-2-propanols. | The synthesis of a series of 1-(acylaminomethyl-, ureidomethyl-, and ureidoethylphenoxy)-3-amino-2-propanols is described. The compounds were screened as beta-adrenergic receptor antagonists in cats and their partial agonist activity was evaluated in rats depleted of circulating catecholamines. Some of the compounds ha... | beta-Adrenergic blocking agents. 16. 1-(Acylaminomethyl-, ureidomethyl-, and ureidoethylphenoxy)-3-amino-2-propanols. The synthesis of a series of 1-(acylaminomethyl-, ureidomethyl-, and ureidoethylphenoxy)-3-amino-2-propanols is described. The compounds were screened as beta-adrenergic receptor antagonists in cats and... | [
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PMID:20503 | Adrenerigic agents. 7.1 Synthesis and beta-adrenergic agonist activity of several 2-pyridylethanolamines. | In a search for new selective bronchodilators, three 2-pyridylethanolamines, i.e., 2-tert-butylamino-1-(5-hydroxy-2-pyridyl)ethanol (2b), a related 6-methylsulfonylmethyl (2c), and, a 6-methyl (2d) derivative, were prepared. These compounds were examined for potential bronchodilator activity in an in vitro test for rel... | Adrenerigic agents. 7.1 Synthesis and beta-adrenergic agonist activity of several 2-pyridylethanolamines. In a search for new selective bronchodilators, three 2-pyridylethanolamines, i.e., 2-tert-butylamino-1-(5-hydroxy-2-pyridyl)ethanol (2b), a related 6-methylsulfonylmethyl (2c), and, a 6-methyl (2d) derivative, were... | [
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PMID:20504 | Adrenergic agents. 8.1 Synthesis and beta-adrenergic agonist activity of some 3-tert-butylamino-2-(substituted phenyl)-1-propanols. | Replacement of the benzylic hydroxyl group of N-tert-butylnorepinephrine with a hydroxymethyl substituent affords a propanolamine homologue which retains a high degree of beta-adrenergic agonist activity. As modification of the meta substituent of catecholic ethanolamines, such as N-tert-butylnorepinephrine, often prov... | Adrenergic agents. 8.1 Synthesis and beta-adrenergic agonist activity of some 3-tert-butylamino-2-(substituted phenyl)-1-propanols. Replacement of the benzylic hydroxyl group of N-tert-butylnorepinephrine with a hydroxymethyl substituent affords a propanolamine homologue which retains a high degree of beta-adrenergic a... | [
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PMID:20508 | Ion permeability and strength of cell contacts: ion permeability and mechanical properties of cell contacts in small intestine epithelium. | The effects of several simple parameters (pH, concentration of bivalent cations, osmotic pressure, and temperature) on the ion permeability and mechanical properties of cell contacts have been investigated. It has been shown that the mechanical properties of a cell contact make it possible to describe it as a viscoelas... | Ion permeability and strength of cell contacts: ion permeability and mechanical properties of cell contacts in small intestine epithelium. The effects of several simple parameters (pH, concentration of bivalent cations, osmotic pressure, and temperature) on the ion permeability and mechanical properties of cell contact... | [
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PMID:20513 | Determination of specificity in natural cell-mediated cytotoxicity by natural antibodies. | Natural cell-mediated cytotoxicity (NCMC) and antibody-dependent cell-mediated cytotoxicity (ADCC) appeared to involve similar cytotoxic mechanisms; effector N-cells killed target cells with IgG antibodies attached to the Fc receptor determining the specificity of the reaction. In NCMC the wide range of specificities d... | Determination of specificity in natural cell-mediated cytotoxicity by natural antibodies. Natural cell-mediated cytotoxicity (NCMC) and antibody-dependent cell-mediated cytotoxicity (ADCC) appeared to involve similar cytotoxic mechanisms; effector N-cells killed target cells with IgG antibodies attached to the Fc recep... | [
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PMID:20514 | In vivo immune responses of mice during carcinogenesis by ultraviolet irradiation. | In these experiments, we tested in various in vivo assays the immune responses of inbred C3H/HeN(MTV-) (C3H-) mice during carcinogenesis by chronic exposure to UV irradiation. Although the UV-treated mice were unable to reject syngeneic UV-induced tumor transplants, they rejected H-2-incompatible tumor allografts and H... | In vivo immune responses of mice during carcinogenesis by ultraviolet irradiation. In these experiments, we tested in various in vivo assays the immune responses of inbred C3H/HeN(MTV-) (C3H-) mice during carcinogenesis by chronic exposure to UV irradiation. Although the UV-treated mice were unable to reject syngeneic ... | [
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PMID:20515 | Stimulation of cellular thymidine kinases by human cytomegalovirus. | Thymidine kinase (TK) activity in WI-38 and MRC-5 human fibroblasts was analyzed by discontinuous polyacrylamide gel electrophoresis (disc-PAGE) and discontinuous glycerol gradient electrophoresis (disc-GEP) after subculture or human cytomegalovirus (HCMV) infection. Two peaks of TK activity with different relative fra... | Stimulation of cellular thymidine kinases by human cytomegalovirus. Thymidine kinase (TK) activity in WI-38 and MRC-5 human fibroblasts was analyzed by discontinuous polyacrylamide gel electrophoresis (disc-PAGE) and discontinuous glycerol gradient electrophoresis (disc-GEP) after subculture or human cytomegalovirus (H... | [
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PMID:20516 | Properties of "diplophage": a lipid-containing bacteriophage. | We describe the purification and properties of Dp-1, a bacteriophage isolated from Diplococcus pneumoniae. The phage was sensitive to the organic solvents deoxycholate and Sarkosyl, and its infectivity was reduced by treatment with phospholipase C. Electron microscopy indicated the presence of a double-layered coat aro... | Properties of "diplophage": a lipid-containing bacteriophage. We describe the purification and properties of Dp-1, a bacteriophage isolated from Diplococcus pneumoniae. The phage was sensitive to the organic solvents deoxycholate and Sarkosyl, and its infectivity was reduced by treatment with phospholipase C. Electron ... | [
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PMID:20517 | Specific binding sites for a parvovirus, minute virus of mice, on cultured mouse cells. | The early interactions between parvoviruses and host cells have not been extensively described previously. In this study we have characterized some aspects of viral binding to the cell surface and demonstrated the existence of specific cellular receptor sites for minute virus of mice (MVM) on two murine cell lines that... | Specific binding sites for a parvovirus, minute virus of mice, on cultured mouse cells. The early interactions between parvoviruses and host cells have not been extensively described previously. In this study we have characterized some aspects of viral binding to the cell surface and demonstrated the existence of speci... | [
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PMID:20518 | Division of spermatic vessels in orchiopexy: radionuclide evidence of preservation of testicular circulation. | Satisfactory intrascrotal position of the testicles was achieved by dividing the spermatic vessels, leaving the vas deferens intact, in 3 patients with undescended testes. A postoperative scrotal scan provided objective means of evaluating the adequacy of testicular circulation. To determine the efficacy of various pro... | Division of spermatic vessels in orchiopexy: radionuclide evidence of preservation of testicular circulation. Satisfactory intrascrotal position of the testicles was achieved by dividing the spermatic vessels, leaving the vas deferens intact, in 3 patients with undescended testes. A postoperative scrotal scan provided ... | [
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PMID:20519 | The medical management of angina pectoris. | The availability of excellent short-acting and long-acting drugs for the treatment of angina pectoris needs to be emphasized. Properly used in conjunction with other measures such as the treatment of hypertension and a graded exercise routine, they provide, for most patients with angina, a tested therapeutic program th... | The medical management of angina pectoris. The availability of excellent short-acting and long-acting drugs for the treatment of angina pectoris needs to be emphasized. Properly used in conjunction with other measures such as the treatment of hypertension and a graded exercise routine, they provide, for most patients w... | [
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PMID:20520 | Systemic vasculitis with coexistent large and small vessel involvement. A classification dilemma. | A patient with systemic vasculitis had the palpable purpuric lower extremity lesions of leukocytoclastic vasculitis and the renal aneurysms of polyarteritis nodosa, features thought to clearly separate these two syndromes. Questions are raised pertinent to the classification, diagnosis, treatment, and prognosis of syst... | Systemic vasculitis with coexistent large and small vessel involvement. A classification dilemma. A patient with systemic vasculitis had the palpable purpuric lower extremity lesions of leukocytoclastic vasculitis and the renal aneurysms of polyarteritis nodosa, features thought to clearly separate these two syndromes.... | [
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PMID:20523 | Antihypertensive effect of combined treatment with alpha- and beta-adrenergic blockers in the spontaneously hypertensive rat. | Using a continuous systolic monitor, effects of oral administration of three alpha-adrenergic blockers, i.e. phenoxybenzamine, phentolamine and a new quinazoline compound (2-[4-(n-butyryl)-homopiperazine-1-yl]-4-amino-6, 7-dimethoxy-quinazoline; E-643), on blood pressure and heart rate in normotensive Wistar rats (NWR)... | Antihypertensive effect of combined treatment with alpha- and beta-adrenergic blockers in the spontaneously hypertensive rat. Using a continuous systolic monitor, effects of oral administration of three alpha-adrenergic blockers, i.e. phenoxybenzamine, phentolamine and a new quinazoline compound (2-[4-(n-butyryl)-homop... | [
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PMID:20527 | Response of type B and E Botulinum toxins to purified sulfhydryl-dependent protease produced by Clostridium botulinum type F. | A sulfhydryl-dependent protease (SHP) was purified from a culture of Clostridium botulinum type F. The enzyme can activate type E progenitor toxin completely but type B progenitor toxin only partially. This may suggest that SHP by itself could completely activate the toxin of proteolytic C. botulinum types A and F in c... | Response of type B and E Botulinum toxins to purified sulfhydryl-dependent protease produced by Clostridium botulinum type F. A sulfhydryl-dependent protease (SHP) was purified from a culture of Clostridium botulinum type F. The enzyme can activate type E progenitor toxin completely but type B progenitor toxin only par... | [
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PMID:20529 | [Prevention and therapy of chronic cor pulmonale (author's transl)]. | First prophylactic and therapeutic possibilities in cor pulmonale are shown on the basis of its pathogenesis. Our own results illustrate the effect of therapy of the underlying lung disease and of the concomitant respiratory insufficiency on the pulmonary arterial hypertension. The relationship between pulmonary artery... | [Prevention and therapy of chronic cor pulmonale (author's transl)]. First prophylactic and therapeutic possibilities in cor pulmonale are shown on the basis of its pathogenesis. Our own results illustrate the effect of therapy of the underlying lung disease and of the concomitant respiratory insufficiency on the pulmo... | [
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PMID:20532 | [Indices of human blood acid-base equilibrium and enzymatic activity in short-term antiorthostatic hypokinesia]. | Before and after a 5 day head-down tilt of 4.5 degrees blood samples were withdrawn from different areas of the cardiovascular system of healthy male volunteers. Blood was sampled by means of selective catheterization. Parameters of acid-base equilibrium and activities of aminotransferases and alkaline phosphatase were... | [Indices of human blood acid-base equilibrium and enzymatic activity in short-term antiorthostatic hypokinesia]. Before and after a 5 day head-down tilt of 4.5 degrees blood samples were withdrawn from different areas of the cardiovascular system of healthy male volunteers. Blood was sampled by means of selective cathe... | [
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PMID:20533 | [Skeletal muscle lactate dehydrogenase isoenzymes in rats after space flight and in hypokinesia]. | Carbohydrate metabolism of soleus (red) and plantaris (mixed) muscles of rats exposed to space flight and hypokinesia were studied on a comparative basis. The red and mixed muscles responded in a different way to the exposures, as followed from the changes of the isoenzymic spectrum of LDH. The soleus muscle showed the... | [Skeletal muscle lactate dehydrogenase isoenzymes in rats after space flight and in hypokinesia]. Carbohydrate metabolism of soleus (red) and plantaris (mixed) muscles of rats exposed to space flight and hypokinesia were studied on a comparative basis. The red and mixed muscles responded in a different way to the expos... | [
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PMID:20538 | General principles of antimicrobial therapy. | In the initial therapy of life-threatening infections in which a bacterial cause is suspected, the emphasis should be on broad antibiotic coverage in contrast to definitive therapy, which is dependent on microbial isolation and, when indicated, in vitro susceptibility tests. In severe infections, antimicrobial agents s... | General principles of antimicrobial therapy. In the initial therapy of life-threatening infections in which a bacterial cause is suspected, the emphasis should be on broad antibiotic coverage in contrast to definitive therapy, which is dependent on microbial isolation and, when indicated, in vitro susceptibility tests.... | [
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PMID:20550 | Catecholamine-sensitive adenylate cyclase of human fat cell ghosts: a comparative study using different beta-adrenergic agents. | Some of the effects of beta-adrenergic agonists and antagonists on the adenylate cyclase system of human fat cell ghosts were studied. Isoproterenol, by causing about a fourfold increase of enzyme activity, was more potent than epinephrine and norepinephrine (about 2.5--3.0-fold stimulation). The beta2-adrenergic agoni... | Catecholamine-sensitive adenylate cyclase of human fat cell ghosts: a comparative study using different beta-adrenergic agents. Some of the effects of beta-adrenergic agonists and antagonists on the adenylate cyclase system of human fat cell ghosts were studied. Isoproterenol, by causing about a fourfold increase of en... | [
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PMID:20551 | New evidence for growth hormone modulation by the alpha-adrenergic system in man. | The effect of BS 100-141, N-amidino 2-(2.6 dichlorophenyl) acetamide hydrochloride, a new drug with central alpha-adrenoceptor activity, on growth hormone (GH) secretion was investigated in 24 young, healthy volunteers. Six normal volunteers were treated with 1 mg and 8 with 2 mg BS 100-141; 8 of these 14 were treated ... | New evidence for growth hormone modulation by the alpha-adrenergic system in man. The effect of BS 100-141, N-amidino 2-(2.6 dichlorophenyl) acetamide hydrochloride, a new drug with central alpha-adrenoceptor activity, on growth hormone (GH) secretion was investigated in 24 young, healthy volunteers. Six normal volunte... | [
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PMID:20557 | Adverse reactions after smallpox vaccination. | Nine hundred and thirty-eight reports of adverse reactions of smallpox vaccination in Australia between 1960 and 1976 have been analysed according to the type of reaction, and the age and sex of vaccinee. In an estimated 5,000,000 vaccinations, the reaction rate was 188/million, and the death rate 1-5/million. Generali... | Adverse reactions after smallpox vaccination. Nine hundred and thirty-eight reports of adverse reactions of smallpox vaccination in Australia between 1960 and 1976 have been analysed according to the type of reaction, and the age and sex of vaccinee. In an estimated 5,000,000 vaccinations, the reaction rate was 188/mil... | [
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PMID:20554 | [Hydrogenase activity of the thermophilic hydrogen-oxidizing bacterium Pseudomonas thermophila]. | The hydrogenase activity of the intact cells of a thermophilic hydrogen-oxidizing bacterium Pseudomonas thermophila K-2 was determined using methylene blue; it was several times higher than the rate of hydrogen uptake in the presence of oxygene and carbon dioxide. The activity of membrane-associated hydrogenase was ass... | [Hydrogenase activity of the thermophilic hydrogen-oxidizing bacterium Pseudomonas thermophila]. The hydrogenase activity of the intact cells of a thermophilic hydrogen-oxidizing bacterium Pseudomonas thermophila K-2 was determined using methylene blue; it was several times higher than the rate of hydrogen uptake in th... | [
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PMID:20555 | [Effect of p-chloromercuribenzoate on glutamine synthetase in the food yeast Candida tropicalis]. | The effect of p-CMB on the activity of glutamine synthetase in the fodder yeast Candida tropicalis was studied in the synthetase reaction in Mg-, Mn-, and Co-activated systems and in the transferase reaction. The activity of glutamine synthetase was inhibited by pCMB, the degree of inhibition depending on the presence ... | [Effect of p-chloromercuribenzoate on glutamine synthetase in the food yeast Candida tropicalis]. The effect of p-CMB on the activity of glutamine synthetase in the fodder yeast Candida tropicalis was studied in the synthetase reaction in Mg-, Mn-, and Co-activated systems and in the transferase reaction. The activity ... | [
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PMID:20556 | [Oospora lactis strain actively producing lipase]. | Morphological, cultural and physiological properties of the fungus Oospora lactis producing lipase are described. The activity of lipase depends on the composition of a growth medium, pH, temperature, the duration of cultivation. Optimum conditions for lipase biosynthesis by the fungus have been found. The strain produ... | [Oospora lactis strain actively producing lipase]. Morphological, cultural and physiological properties of the fungus Oospora lactis producing lipase are described. The activity of lipase depends on the composition of a growth medium, pH, temperature, the duration of cultivation. Optimum conditions for lipase biosynthe... | [
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PMID:20561 | [Determination of acid-base parameters by means of programmable pocket calculators (author's transl)]. | The possibility to calculate parameters of acid-base status derived by common laboratory devices without built-in computers is described. The calculation is carried out faster and more exactly than it is possible by nomograms, which is especially suitable when a great quantity of dates occurs. The number of programmabl... | [Determination of acid-base parameters by means of programmable pocket calculators (author's transl)]. The possibility to calculate parameters of acid-base status derived by common laboratory devices without built-in computers is described. The calculation is carried out faster and more exactly than it is possible by n... | [
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PMID:20568 | Purification and properties of alpha-amylase from chicken (Gallus gallus L.) pancreas. | Amylase from chicken pancreas was purified by an affinity method involving filtering a crude extract from pancreas through a Sepharose-wheat albumin column and eluting the retained enzyme with maltose. The purified amylase showed two active bands upon polyacrylamide electrophoresis in an alkaline buffer system and only... | Purification and properties of alpha-amylase from chicken (Gallus gallus L.) pancreas. Amylase from chicken pancreas was purified by an affinity method involving filtering a crude extract from pancreas through a Sepharose-wheat albumin column and eluting the retained enzyme with maltose. The purified amylase showed two... | [
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PMID:20569 | Aminoacyl-tRNA synthetases from calf liver: optimized assay conditions and kinetic properties. | Kinetic studies have been performed on the "family" of aminoacyl synthetases from calf liver. All assays were based on the esterification of amino acids to tRNA. Optimized reaction conditions for each synthetase are reported. Most of the synthetases show hyperbolic kinetics with respect to both amino acid and tRNA conc... | Aminoacyl-tRNA synthetases from calf liver: optimized assay conditions and kinetic properties. Kinetic studies have been performed on the "family" of aminoacyl synthetases from calf liver. All assays were based on the esterification of amino acids to tRNA. Optimized reaction conditions for each synthetase are reported.... | [
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PMID:20570 | [Recent progress in research on the central regulation of growth hormone secretion (author's transl)]. | The secretion of pituitary and peripheral hormones is regulated by a chain of reactions in the central nervous system. According to current knowledge this chain consists of the following links: external and internal stimuli leads to mesencephalon leads to limbic system leads to monoaminergic neurones leads to hypothala... | [Recent progress in research on the central regulation of growth hormone secretion (author's transl)]. The secretion of pituitary and peripheral hormones is regulated by a chain of reactions in the central nervous system. According to current knowledge this chain consists of the following links: external and internal s... | [
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PMID:20571 | [Special problems of asthma bronchiale in childhood (author's transl)]. | Asthma bronchiale is one of the most common chronic diseases in childhood. The hyperreactivity of the bronchial system, the stimulation of the cholinergic receptors and the blockade of the beta-adrenergic receptors in the bronchial mucosa play a predominant role in the pathogenesis. These proceedings cause bronchial sm... | [Special problems of asthma bronchiale in childhood (author's transl)]. Asthma bronchiale is one of the most common chronic diseases in childhood. The hyperreactivity of the bronchial system, the stimulation of the cholinergic receptors and the blockade of the beta-adrenergic receptors in the bronchial mucosa play a pr... | [
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PMID:20572 | Comparative effects of antacids, cimetidine and enteric coating on the therapeutic response to oral enzymes in severe pancreatic insufficiency. | To provide a rational basis for pancreatic enzyme replacement therapy, we evaluated, in six patients with advanced pancreatic insufficiency, the effects of various treatment regimens on fecal fat and nitrogen balance and on duodenal recovery of ingested pancreatic enzymes after a solid test meal. The combination of cim... | Comparative effects of antacids, cimetidine and enteric coating on the therapeutic response to oral enzymes in severe pancreatic insufficiency. To provide a rational basis for pancreatic enzyme replacement therapy, we evaluated, in six patients with advanced pancreatic insufficiency, the effects of various treatment re... | [
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PMID:20575 | Polyvalent pneumococcal-polysaccharide immunization of patients with sickle-cell anemia and patients with splenectomy. | To reduce the risk of infection from Streptococcus pneumoniae in hyposplenic patients we administered octavalent pneumococcal vaccine to 77 patients with sickle-cell disease and 19 asplenic persons and compared their response with 82 controls (38 age-matched normal persons and 44 normal black African children). Fifty m... | Polyvalent pneumococcal-polysaccharide immunization of patients with sickle-cell anemia and patients with splenectomy. To reduce the risk of infection from Streptococcus pneumoniae in hyposplenic patients we administered octavalent pneumococcal vaccine to 77 patients with sickle-cell disease and 19 asplenic persons and... | [
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PMID:20582 | The facilitatory actions of aminopyridines and tetraethylammonium on neuromuscular transmission and muscle contractility in avian muscle. | The actions of 3,4-diaminopyridine, 4-aminopyridine and tetraethylammonium were studied on the chick biventer cervicis muscle preparation. All three compounds produced a greater augmentation of indirectly elicited twitches than of directly elicited twitches. The compounds did not restore transmission in OmMCa2+ solutio... | The facilitatory actions of aminopyridines and tetraethylammonium on neuromuscular transmission and muscle contractility in avian muscle. The actions of 3,4-diaminopyridine, 4-aminopyridine and tetraethylammonium were studied on the chick biventer cervicis muscle preparation. All three compounds produced a greater augm... | [
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PMID:20583 | Effects of db cAMP on tyrosine hydroxylase activity of ganglia and nerve endings. | Preincubation of intact superior cervical ganglia or nictitating membrane for 2 h with dibutyryl cyclic AMP (db cAMP) increased the hydroxylation of tyrosine. This effect was not blocked by the protein synthesis inhibitor, cycloheximide. The Km of tyrosine hydroxylase for the substrate, tyrosine, and for the cofactor, ... | Effects of db cAMP on tyrosine hydroxylase activity of ganglia and nerve endings. Preincubation of intact superior cervical ganglia or nictitating membrane for 2 h with dibutyryl cyclic AMP (db cAMP) increased the hydroxylation of tyrosine. This effect was not blocked by the protein synthesis inhibitor, cycloheximide. ... | [
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PMID:20584 | Naloxone-precipitated withdrawal reveals sensitization to neurotransmitters in morphine tolerant/dependent rats. | Morphine tolerant/dependent rats were tested for their sensitivity to putative neurotransmitters or other receptor agonists injected intracerebroventricularly (i.c.v.) during naloxone-precipitated withdrawal. Dopamine, apomorphine, clonidine and serotonin were found to reinitiate withdrawal jumping behaviour when injec... | Naloxone-precipitated withdrawal reveals sensitization to neurotransmitters in morphine tolerant/dependent rats. Morphine tolerant/dependent rats were tested for their sensitivity to putative neurotransmitters or other receptor agonists injected intracerebroventricularly (i.c.v.) during naloxone-precipitated withdrawal... | [
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PMID:20586 | Enhanced sympathetic activity in young spontaneously hypertensive rats is not the trigger mechanism for genetic hypertension. | In young, spontaneously hypertensive rats (SHR), a preganglionic, nerve-dependent, elevation of choline acetyltransferase (ChAc) and tyrosine hydroxylase (TH) activities was found in celiac ganglia as compared with those in young, normotensive Kyoto Wistar rats, that was not present in superior cervical ganglia, stella... | Enhanced sympathetic activity in young spontaneously hypertensive rats is not the trigger mechanism for genetic hypertension. In young, spontaneously hypertensive rats (SHR), a preganglionic, nerve-dependent, elevation of choline acetyltransferase (ChAc) and tyrosine hydroxylase (TH) activities was found in celiac gang... | [
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PMID:20592 | [A case of polyarteritis nodosa associated with pulmonary hypertension]. | A case of polyarteritis nodosa marked by concomitant systemic and pulmonary hypertension is presented. The part played by pulmonary hypertension in this disease is briefly discussed in the light of the necropsy findings and the literature. | [A case of polyarteritis nodosa associated with pulmonary hypertension]. A case of polyarteritis nodosa marked by concomitant systemic and pulmonary hypertension is presented. The part played by pulmonary hypertension in this disease is briefly discussed in the light of the necropsy findings and the literature. | [
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PMID:20594 | [Effect of age of mouse recipients on the functional activity of transplanted hematopoietic and lymphoid cells]. | When transplanting the bone marrow cells from adult C57BL mice to the lethally irradiated (CBA X C57BL) F1 hybrids of different age, the decrease of the colony forming activity of the stem haemopoietic cells was observed in the spleen of the older recipients, as compared with the 3 months old ones. The joint transplant... | [Effect of age of mouse recipients on the functional activity of transplanted hematopoietic and lymphoid cells]. When transplanting the bone marrow cells from adult C57BL mice to the lethally irradiated (CBA X C57BL) F1 hybrids of different age, the decrease of the colony forming activity of the stem haemopoietic cells... | [
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PMID:20595 | Familial tyrosinaemia with eye and skin lesions. Presentation of two cases. | Two cases of tyrosinaemia with eye and skin lesions typical of the Richner-Hanhart syndrome are described. The patients are a 29- and 26-year-old brother and sister. They do not show neurological abnormalities or mental retardation. Parents are not consanguineous and family history is negative for similar conditions. T... | Familial tyrosinaemia with eye and skin lesions. Presentation of two cases. Two cases of tyrosinaemia with eye and skin lesions typical of the Richner-Hanhart syndrome are described. The patients are a 29- and 26-year-old brother and sister. They do not show neurological abnormalities or mental retardation. Parents are... | [
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PMID:20596 | Prenatal diagnosis of metachromatic leukodystrophy by electrophoretic and immunologic techniques. | Electrophoretic examination of extracts of cultured amniotic fluid cells from a pregnancy at risk for metachromatic leukodystrophy (MLD) showed absence of arylsulfatase A (AS-A) activity. Immunodiffusion with anti-human AS-A immune serum failed to show enzymatically active arcs of immune precipitate. Electrophoretic st... | Prenatal diagnosis of metachromatic leukodystrophy by electrophoretic and immunologic techniques. Electrophoretic examination of extracts of cultured amniotic fluid cells from a pregnancy at risk for metachromatic leukodystrophy (MLD) showed absence of arylsulfatase A (AS-A) activity. Immunodiffusion with anti-human AS... | [
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PMID:20597 | A patient with severe neurologic symptoms and acetoacetyl-CoA thiolase deficiency. | A detailed kinetic characterization of the cytosolic acetoacetyl-CoA thiolase in liver, subcutaneous adipose tissue, and cultured fibroblasts of a patient with severe neurologic symptoms showed this enzyme to be much more sensitive to inhibition by CoA than that enzyme of normal human liver. The activity of the cytosol... | A patient with severe neurologic symptoms and acetoacetyl-CoA thiolase deficiency. A detailed kinetic characterization of the cytosolic acetoacetyl-CoA thiolase in liver, subcutaneous adipose tissue, and cultured fibroblasts of a patient with severe neurologic symptoms showed this enzyme to be much more sensitive to in... | [
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PMID:20600 | An emerging zoonosis in Scandinavia -- nephropathia epidemica. | The paper reviews as zoonosis the disease called Nephropathia epidemica in north European countries. The etiology is as yet unsolved but a viral one is highly suspected with small rodents (voles and mice) as the source of infection. Based on the epidemiological peculiarities of the disease, the ecology of the agent and... | An emerging zoonosis in Scandinavia -- nephropathia epidemica. The paper reviews as zoonosis the disease called Nephropathia epidemica in north European countries. The etiology is as yet unsolved but a viral one is highly suspected with small rodents (voles and mice) as the source of infection. Based on the epidemiolog... | [
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PMID:20602 | [The renin-angiotensin-aldosterone system in hypertensive subjects. III- The use of beta-blockers in reno-vascular hypertension (author's transl)]. | Six patients with permanent hypertension with renal artery stenosis were treated by conservative reparative surgery appart from one of them (unilateral nephrectomy) and were all seen again at the 8th month at the earliest in the absence of any anti-hypertensive therapy. Study of the renin-angiotensin system carried out... | [The renin-angiotensin-aldosterone system in hypertensive subjects. III- The use of beta-blockers in reno-vascular hypertension (author's transl)]. Six patients with permanent hypertension with renal artery stenosis were treated by conservative reparative surgery appart from one of them (unilateral nephrectomy) and wer... | [
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PMID:20603 | Enzymatic synthesis of Q nucleoside containing mannose in the anticodon of tRNA: isolation of a novel mannosyltransferase from a cell-free extract of rat liver. | The Q nucleosides isolated from rabbit liver tRNA are known to have sugars (mannose or galactose) linked to their cyclopentene diol moiety. A Q nucleoside containing mannose (manQ) was synthesized by a cell-free system from rat liver, using purified E. coli tRNAAsp as an acceptor and GDP-mannose as a donor molecule. Th... | Enzymatic synthesis of Q nucleoside containing mannose in the anticodon of tRNA: isolation of a novel mannosyltransferase from a cell-free extract of rat liver. The Q nucleosides isolated from rabbit liver tRNA are known to have sugars (mannose or galactose) linked to their cyclopentene diol moiety. A Q nucleoside cont... | [
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PMID:20604 | The role of the AT pairs in the acid denaturation of DNA. | It has been determined previously that the protonation of the GC pairs induces a DNA conformation change which leads to a "metastable" structure. The role of the AT pairs, however, is no well known because the protonation does not modify their spectral properties. By means of an indirect method based on the binding of ... | The role of the AT pairs in the acid denaturation of DNA. It has been determined previously that the protonation of the GC pairs induces a DNA conformation change which leads to a "metastable" structure. The role of the AT pairs, however, is no well known because the protonation does not modify their spectral propertie... | [
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PMID:20608 | Participation of 5-hydroxytryptamine in anticonvulsive action of benzodiazepines. | The influence of several compounds activating or producing hypofunction of the serotonergic system was studied on the convulsive threshold and anticonvulsive action of benzodiazepines (chlordiazepoxide, diazepam, oxazepam, nitrazepam) in the pentylenetetrazol test. No changes in the convulsive threshold either for clon... | Participation of 5-hydroxytryptamine in anticonvulsive action of benzodiazepines. The influence of several compounds activating or producing hypofunction of the serotonergic system was studied on the convulsive threshold and anticonvulsive action of benzodiazepines (chlordiazepoxide, diazepam, oxazepam, nitrazepam) in ... | [
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PMID:20609 | The effect of alpha-adrenolytics on central action of agonists and antagonists of dopaminergic system. | alpha-Adrenoceptor blocking agents: phenoxybenzamine, phentolamine and aceperone, potentiated and prolonged amphetamine and apomorphine stereotypy in the rat, but inhibited the amphetamine hypermotility. The hypermotility produced by apomorphine was antagonized only by aceperone. Cataleptogenic action of haloperidol an... | The effect of alpha-adrenolytics on central action of agonists and antagonists of dopaminergic system. alpha-Adrenoceptor blocking agents: phenoxybenzamine, phentolamine and aceperone, potentiated and prolonged amphetamine and apomorphine stereotypy in the rat, but inhibited the amphetamine hypermotility. The hypermoti... | [
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PMID:20610 | The effect of beta-adrenergic receptor blocking agents on hypertensive action of noradrenaline injected into the lateral ventricle of rat brain. | Noradrenaline (NA), 100 microgram intraventricularly (ivtr), produces an evident hypertension, lasting for up to 15 min. A previous ivtr administration of propranolol (100 and 500 microgram), alprenolol (100 microgram), sotalol (100 microgram), (-)INPEA (100 microgram), (+)INPEA (100 microgram), Ko 1366 (100 and 200 mi... | The effect of beta-adrenergic receptor blocking agents on hypertensive action of noradrenaline injected into the lateral ventricle of rat brain. Noradrenaline (NA), 100 microgram intraventricularly (ivtr), produces an evident hypertension, lasting for up to 15 min. A previous ivtr administration of propranolol (100 and... | [
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PMID:20611 | Kinetics of drug decomposition. Part 45. Logk--pH profile for rolitetracycline degradation. | UV spectrophotometry and fluorometry were applied for an examination of rolitetracycline (RT) degradation at pH's ranged from ca 0-8 to 13-0. It was demonstrated that these methods enable to follow the rate of degradation of tetracycline formed in the course of RT hydrolysis. However, they do not allow to monitor the h... | Kinetics of drug decomposition. Part 45. Logk--pH profile for rolitetracycline degradation. UV spectrophotometry and fluorometry were applied for an examination of rolitetracycline (RT) degradation at pH's ranged from ca 0-8 to 13-0. It was demonstrated that these methods enable to follow the rate of degradation of tet... | [
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PMID:20612 | Kinetics and mechanism of degradation of some 2-sulfanilamidopyrimidine derivatives. Part III. The use of Hammett equation for kinetic investigation of 2-sulfanilamidopyrimidine derivatives autoxidation. | General first-order rate constants for autoxidation of sulfadiazine, sulfamerazine, sulfadimidine, sulfaperine and sulfamethoxydiazine in the air oxygen atmosphere, in solutions of pH 4-7, at 403, 411 and 418 K were determined from the absorbance measurements in 0-1 mole/dm3 HCl at 243 or 333 nm, using the so-called "s... | Kinetics and mechanism of degradation of some 2-sulfanilamidopyrimidine derivatives. Part III. The use of Hammett equation for kinetic investigation of 2-sulfanilamidopyrimidine derivatives autoxidation. General first-order rate constants for autoxidation of sulfadiazine, sulfamerazine, sulfadimidine, sulfaperine and s... | [
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PMID:20615 | Purification and properties of a ribonuclease in human urine that hydrolyses polycytidylic acid. | Human urine RNase was purified about 2000-fold. The preparation is free from phosphatase, phosphodiesterase and DNase activities. On electrophoresis through polyacrylamide gel at pH 8.3, it migrates toward the anode and stains with periodic acid-Schiff reagent, suggesting that it is acidic and glycoprotein in nature. I... | Purification and properties of a ribonuclease in human urine that hydrolyses polycytidylic acid. Human urine RNase was purified about 2000-fold. The preparation is free from phosphatase, phosphodiesterase and DNase activities. On electrophoresis through polyacrylamide gel at pH 8.3, it migrates toward the anode and sta... | [
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PMID:20613 | Kinetics of drug decomposition. Part 48. Specific acid-base hydrolysis of rolitetracycline. | Using chromatographic-spectrophotometric method, the effect of H+ and OH- ions on the rate of hydrolysis of rolitetracycline (RT) to tetracycline (T) at 20degreeC was investigated. The advantage of this analytical procedure over the direct fluorescence or UV absorption measurements of RT solutions during the kinetic in... | Kinetics of drug decomposition. Part 48. Specific acid-base hydrolysis of rolitetracycline. Using chromatographic-spectrophotometric method, the effect of H+ and OH- ions on the rate of hydrolysis of rolitetracycline (RT) to tetracycline (T) at 20degreeC was investigated. The advantage of this analytical procedure over... | [
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PMID:20617 | [Properties of urease immobilized by chemical binding to a derivatives of cellulose]. | A comparative study of properties of soluble urease and urease immobilized by its binding to cellulose derivatives was carried out. Upon chemical binding of urease to cellulose derivatives the Mikhaelis constant and pH optimum for the enzyme action changed insignificantly. Maximum enzymic activity of soluble and immobi... | [Properties of urease immobilized by chemical binding to a derivatives of cellulose]. A comparative study of properties of soluble urease and urease immobilized by its binding to cellulose derivatives was carried out. Upon chemical binding of urease to cellulose derivatives the Mikhaelis constant and pH optimum for the... | [
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PMID:20620 | Primary photochemical event in vision: proton translocation. | Picosecond studies of rhodopsin in low-temperature glasses have been carried out in order to observe directly the risetime of prelumirhodopsin, the first intermediate in the visual pathway. Only at 20 K or below can the risetime of this intermediate be resolved and even at 4 K it is astoundingly rapid, about 36 psec. A... | Primary photochemical event in vision: proton translocation. Picosecond studies of rhodopsin in low-temperature glasses have been carried out in order to observe directly the risetime of prelumirhodopsin, the first intermediate in the visual pathway. Only at 20 K or below can the risetime of this intermediate be resolv... | [
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PMID:20618 | [Denaturation of the alpha-amylase of Bacillus subtilis in an acid medium]. | By fractionation of purine compounds (sorbtion on the cation exchange resin KU-2 (H+), extraction, precipitation of purine compounds as Ag-complexes) a "purine fraction" of the culture liquid epiphytic bacteria No. 703 isolated from barley overground organs was obtained. The presence of isopentenyl cytokinins was demon... | [Denaturation of the alpha-amylase of Bacillus subtilis in an acid medium]. By fractionation of purine compounds (sorbtion on the cation exchange resin KU-2 (H+), extraction, precipitation of purine compounds as Ag-complexes) a "purine fraction" of the culture liquid epiphytic bacteria No. 703 isolated from barley over... | [
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PMID:20621 | Sodium-stimulated glutamate uptake in membrane vesicles of Escherichia coli: the role of ion gradients. | Membrane vesicles prepared from Escherichia coli B/r grown on glutamate as a sole source of carbon and energy require sodium for glutamate accumulation when energized by D-lactate oxidation. Glutamate uptake can also be driven by a prearranged sodium gradient (out to in) in the absence of an energy source or a protonmo... | Sodium-stimulated glutamate uptake in membrane vesicles of Escherichia coli: the role of ion gradients. Membrane vesicles prepared from Escherichia coli B/r grown on glutamate as a sole source of carbon and energy require sodium for glutamate accumulation when energized by D-lactate oxidation. Glutamate uptake can also... | [
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PMID:20619 | [Metabolism of sex steroid hormones in neuroendocrine organs. I. In vitro androgen metabolism in the hypophyses and epiphyses of rats during the puberal period]. | Metabolism of tritium-labeled testosterone, delta4-androstane-3, 17-dion, dihydrotestosterone. 5alpha-androstane-3alpha, 17beta-diod and 5alpha-androstane-3beta, 17beta-dion by the isolated hypophyses and epiphyses of male and female 30-day rats was studied. The glands were incubated in Eagle's medium containing the me... | [Metabolism of sex steroid hormones in neuroendocrine organs. I. In vitro androgen metabolism in the hypophyses and epiphyses of rats during the puberal period]. Metabolism of tritium-labeled testosterone, delta4-androstane-3, 17-dion, dihydrotestosterone. 5alpha-androstane-3alpha, 17beta-diod and 5alpha-androstane-3be... | [
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PMID:20622 | Fatty acid synthetase from Brevibacterium ammoniagenes: formation of monounsaturated fatty acids by a multienzyme complex. | A multienzyme fatty acid synthetase complex isolated from Brevibacterium ammoniagenes has been purified to a specific activity of 1440 nmol of malonyl-CoA incorporated per min/mg. The enzyme is homogeneous, as judged by gel electrophoresis on agarose gels, and has a molecular weight of 1.2 X 10(6). Both NADPH and NADH ... | Fatty acid synthetase from Brevibacterium ammoniagenes: formation of monounsaturated fatty acids by a multienzyme complex. A multienzyme fatty acid synthetase complex isolated from Brevibacterium ammoniagenes has been purified to a specific activity of 1440 nmol of malonyl-CoA incorporated per min/mg. The enzyme is hom... | [
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PMID:20623 | Nitric oxide activates guanylate cyclase and increases guanosine 3':5'-cyclic monophosphate levels in various tissue preparations. | Nitric oxide gas (NO) increased guanylate cyclase [GTP pyrophosphate-lyase (cyclizing), EC 4.6.1.2] activity in soluble and particulate preparations from various tissues. The effect was dose-dependent and was observed with all tissue preparations examined. The extent of activation was variable among different tissue pr... | Nitric oxide activates guanylate cyclase and increases guanosine 3':5'-cyclic monophosphate levels in various tissue preparations. Nitric oxide gas (NO) increased guanylate cyclase [GTP pyrophosphate-lyase (cyclizing), EC 4.6.1.2] activity in soluble and particulate preparations from various tissues. The effect was dos... | [
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PMID:20624 | Unequivocal demonstration of fructose-1,6-bisphosphatase in mammalian brain. | Fructose-1,6-bisphosphatase (D-fructose-1,6-bisphosphate 1-phosphohydrolase; EC 3.1.3.11) has been found in rat brain and identified unequivocally. The enzyme has been purified to 95% homogeneity by standard procedures, including adsorption to a phosphocellulose column followed by elution with substrate. The purified e... | Unequivocal demonstration of fructose-1,6-bisphosphatase in mammalian brain. Fructose-1,6-bisphosphatase (D-fructose-1,6-bisphosphate 1-phosphohydrolase; EC 3.1.3.11) has been found in rat brain and identified unequivocally. The enzyme has been purified to 95% homogeneity by standard procedures, including adsorption to... | [
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PMID:20625 | Resonance Raman spectroscopy of arsanilazocarboxypeptidase A: determination of the nature of the azotyrosyl-248-zinc complex. | Resonance Raman spectra of arsanilazotryosyl-248 carboxypeptidase A (peptidyl-L-amino-acid hydrolase, EC 3.4.12.2) exhibit only the vibrational bands of its chromophoric azotyrosyl-248 residue uncomplicated by background interference from either water or other components of the protein. The resonance Raman spectra cont... | Resonance Raman spectroscopy of arsanilazocarboxypeptidase A: determination of the nature of the azotyrosyl-248-zinc complex. Resonance Raman spectra of arsanilazotryosyl-248 carboxypeptidase A (peptidyl-L-amino-acid hydrolase, EC 3.4.12.2) exhibit only the vibrational bands of its chromophoric azotyrosyl-248 residue u... | [
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PMID:20626 | Selective inhibition of gamma-glutamyl-cycle enzymes by substrate analogs. | Substrate analogs have been obtained that selectively inhibit the reactions of the gamma-glutamyl cycle or that are susceptible to only limited metabolism by the cycle. Thus, glutathione synthesis may be inhibited and analogs of glutathione may be synthesized that do not participate in transpeptidation. Specific inhibi... | Selective inhibition of gamma-glutamyl-cycle enzymes by substrate analogs. Substrate analogs have been obtained that selectively inhibit the reactions of the gamma-glutamyl cycle or that are susceptible to only limited metabolism by the cycle. Thus, glutathione synthesis may be inhibited and analogs of glutathione may ... | [
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PMID:20627 | Quantum efficiency of photosynthetic energy conversion. | The quantum efficiency of photosynthetic energy conversion was investigated in isolated spinach chloroplasts by measurements of the quantum requirements of ATP formation by cyclic and noncyclic photophosphorylation catalyzed by ferredoxin. ATP formation had a requirement of about 2 quanta per 1 ATP at 715 nm (correspon... | Quantum efficiency of photosynthetic energy conversion. The quantum efficiency of photosynthetic energy conversion was investigated in isolated spinach chloroplasts by measurements of the quantum requirements of ATP formation by cyclic and noncyclic photophosphorylation catalyzed by ferredoxin. ATP formation had a requ... | [
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PMID:20628 | Embryologic development of a mouse sympathetic ganglion in vivo and in vitro. | The morphologic and biochemical development of the embryonic mouse superior cervical ganglion was characterized in vivo and in tissue culture. From 13 days of gestation, when the superior cervical ganglion was first visible, to birth at 19 days, tyrosine hydroxylase [tyrosine 3-monooxygenase; L-tyrosine, tetrahydropter... | Embryologic development of a mouse sympathetic ganglion in vivo and in vitro. The morphologic and biochemical development of the embryonic mouse superior cervical ganglion was characterized in vivo and in tissue culture. From 13 days of gestation, when the superior cervical ganglion was first visible, to birth at 19 da... | [
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PMID:20629 | Thyrotropin-releasing hormone-like material in the rat retina: changes due to environmental lighting. | Material reacting with an antibody to thyrotropin-releasing hormone (TRH) has been found to be present in the rat retina. The compound present in the retina cochromatographed with authentic TRH and most of its activity was lost when incubated with pyroglutamate aminopeptidase (L-pyroglutamyl-peptide hydrolase, EC 3.4.1... | Thyrotropin-releasing hormone-like material in the rat retina: changes due to environmental lighting. Material reacting with an antibody to thyrotropin-releasing hormone (TRH) has been found to be present in the rat retina. The compound present in the retina cochromatographed with authentic TRH and most of its activity... | [
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PMID:20630 | Stimulation of human platelet guanylate cyclase by unsaturated fatty acid peroxides. | Guanylate cyclase [GTP pyrophosphate-lyase (cyclizing), EC 4.6.1.2] activity of human platelet homogenates was stimulated by the addition of phospholipase A2 or unsaturated fatty acids such as oleic, vaccenic, linoleic, linolenic, eicosenoic, eicosadienoic, and arachidonic acids. The addition of lipoxidase potentiated ... | Stimulation of human platelet guanylate cyclase by unsaturated fatty acid peroxides. Guanylate cyclase [GTP pyrophosphate-lyase (cyclizing), EC 4.6.1.2] activity of human platelet homogenates was stimulated by the addition of phospholipase A2 or unsaturated fatty acids such as oleic, vaccenic, linoleic, linolenic, eico... | [
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PMID:20631 | Purification and properties of human erythrocyte pyrimidine 5'-nucleotidase. | A 250,000-fold purification of pyrimidine 5'-nucleotidase from human erythrocytes has been achieved using a combination of DEAE-cellulose chromatography, ammonium sulfate fractionation, gel filtration, and isoelectric focusing. Polyacrylamide disc and starch gel electrophoresis of the purified material show two strong ... | Purification and properties of human erythrocyte pyrimidine 5'-nucleotidase. A 250,000-fold purification of pyrimidine 5'-nucleotidase from human erythrocytes has been achieved using a combination of DEAE-cellulose chromatography, ammonium sulfate fractionation, gel filtration, and isoelectric focusing. Polyacrylamide ... | [
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PMID:20632 | Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding. | [3H]Diazepam appears to bind specifically to a single, saturable, binding site located on rat brain membranes, with an affinity constant near 3 nM at pH 7.4. Specific binding constitutes more than 90% of total binding at 0 degrees and less than 10% of total binding at 37 degrees. Arrhenius plots suggest a sharp conform... | Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding. [3H]Diazepam appears to bind specifically to a single, saturable, binding site located on rat brain membranes, with an affinity constant near 3 nM at pH 7.4. Specific binding constitutes more than 90% of total binding at... | [
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PMID:20633 | Kinetics of the alkaline tetramer leads to dimer dissociation in liganded human hemoglobin: a laser light-scattering stopped-flow study. | The first-order dissociation of tetrameric HbCO to the dimer has been studied overthe pH range 10.30-11.57 in a light-scattering stopped-flow apparatus using argon-ion laser excitation. The first-order dissociation rate constant varies from 0.25 sec-1 to 24.0 sec-1over this pH interval. A semilogarithmic plot of k vers... | Kinetics of the alkaline tetramer leads to dimer dissociation in liganded human hemoglobin: a laser light-scattering stopped-flow study. The first-order dissociation of tetrameric HbCO to the dimer has been studied overthe pH range 10.30-11.57 in a light-scattering stopped-flow apparatus using argon-ion laser excitatio... | [
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PMID:20647 | Antimuscarinic properties of antidepressants: dibenzepin (Noveril). | The antimuscarinic potency of dibenzepin (Noveril) was estimated by measuring (a) central in vivo effects in mice (antihypothermia and antitremor, both induced by oxotremorine), (b) peripheral in vivo activity (mydriasis caused by systemic administration of the drug), (c) the effects of dibenzepin on isolated smooth mu... | Antimuscarinic properties of antidepressants: dibenzepin (Noveril). The antimuscarinic potency of dibenzepin (Noveril) was estimated by measuring (a) central in vivo effects in mice (antihypothermia and antitremor, both induced by oxotremorine), (b) peripheral in vivo activity (mydriasis caused by systemic administrati... | [
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PMID:20648 | [Stability of tetracycline during fermentation]. | The stability of tetracycline was studied at pH 6.0 and 1.5. The thermal inactivation constant at the lower pH was found to vary between 1.62 min-1 (40 degrees C) and 65.83 min-1 (100 degrees C). A degradation mechanism was proposed in the light of the variation of entropy and steric factors. | [Stability of tetracycline during fermentation]. The stability of tetracycline was studied at pH 6.0 and 1.5. The thermal inactivation constant at the lower pH was found to vary between 1.62 min-1 (40 degrees C) and 65.83 min-1 (100 degrees C). A degradation mechanism was proposed in the light of the variation of entro... | [
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PMID:20652 | beta-blocking agents and human fat cell adenylate cyclase. | The effects of various beta-blocking agents upon the catecholamine-activated adenylate cyclase of human fat cell ghosts were studied. Both non-selective and cardio-selective beta-blocking drugs are capable in inhibiting the human enzyme system. The concentrations of the non-selective beta-blockers (bupranolol, alprenol... | beta-blocking agents and human fat cell adenylate cyclase. The effects of various beta-blocking agents upon the catecholamine-activated adenylate cyclase of human fat cell ghosts were studied. Both non-selective and cardio-selective beta-blocking drugs are capable in inhibiting the human enzyme system. The concentratio... | [
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PMID:20653 | [The effect of sympathomimetric drugs on exocrine pancreatic function. Studies in the isolated cat pancreas (author's transl)]. | This study reports on effects of beta-sympathomimetic drugs on the exocrine function of the isolated cat pancreas. The injection of these drugs resulted in an increase of pancreatic protein and enzyme secretion, the excretion of calcium into the juice and the rate of volume output were not changed. The enzyme secretion... | [The effect of sympathomimetric drugs on exocrine pancreatic function. Studies in the isolated cat pancreas (author's transl)]. This study reports on effects of beta-sympathomimetic drugs on the exocrine function of the isolated cat pancreas. The injection of these drugs resulted in an increase of pancreatic protein an... | [
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PMID:20654 | Quantifying drugs influence on cardio-respiratory synchronism. | The paper concerns the situation in which, for a considerable time, the onset of each respiratory cycle coincides with one and the same section of a cardiac cycle. A standardized procedure is described with which, in anesthetized rabbits, the potentiality of the biological mechanisms responsible for the phenomenon may ... | Quantifying drugs influence on cardio-respiratory synchronism. The paper concerns the situation in which, for a considerable time, the onset of each respiratory cycle coincides with one and the same section of a cardiac cycle. A standardized procedure is described with which, in anesthetized rabbits, the potentiality o... | [
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PMID:20656 | A placebo-controlled, double-blind trial of Benorylate tablets in the treatment of bursitis and synovitis due to sports injury. | In this two-week study, Benoral tablets, at a 4.5 g daily dosage were compared with a matching placebo in 20 patients suffering from sports injury. Four assessments were made: pain at rest, pain on movement, tenderness and soft tissue swelling. In each case the active treatment group (benorylate) was statistically grea... | A placebo-controlled, double-blind trial of Benorylate tablets in the treatment of bursitis and synovitis due to sports injury. In this two-week study, Benoral tablets, at a 4.5 g daily dosage were compared with a matching placebo in 20 patients suffering from sports injury. Four assessments were made: pain at rest, pa... | [
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0.03232068940997124,
0.017... |
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