id stringlengths 7 10 | title stringlengths 8 354 | content stringlengths 91 4.1k | contents stringlengths 164 4.24k | embedding listlengths 384 384 |
|---|---|---|---|---|
PMID:22535 | gltB gene and regulation of nitrogen metabolism by glutamine synthetase in Escherichia coli. | A mutant (gltB) of Escherichia coli lacking glutamate synthase (GOGAT) was unable to utilize a wide variety of compounds as sole nitrogen source (e.g., arginine, proline, gamma-aminobutyrate, and glycine). Among revertants of these Asm- strains selected on one of these compounds (e.g., arginine, proline, or gamma-amino... | gltB gene and regulation of nitrogen metabolism by glutamine synthetase in Escherichia coli. A mutant (gltB) of Escherichia coli lacking glutamate synthase (GOGAT) was unable to utilize a wide variety of compounds as sole nitrogen source (e.g., arginine, proline, gamma-aminobutyrate, and glycine). Among revertants of t... | [
-0.03550909832119942,
-0.0026436906773597,
-0.06096666306257248,
-0.0023381393402814865,
0.02810114063322544,
0.0055708265863358974,
0.025214575231075287,
-0.021878035739064217,
-0.08168821781873703,
0.02411489374935627,
0.024238346144557,
-0.09061377495527267,
0.05179028585553169,
0.01123... |
PMID:22536 | Purification and properties of an extracellular protease from Myxococcus virescens. | An extracellular protease from Myxococcus virescens was purified by phosphate precipitation, gel exclusion, and ion-exchange chromatography. The enzyme appeared homogeneous upon disc electrophoresis. The molecular weight of the protease was estimated to be 26,000. The enzyme was rapidly inactivated by ethylenediaminete... | Purification and properties of an extracellular protease from Myxococcus virescens. An extracellular protease from Myxococcus virescens was purified by phosphate precipitation, gel exclusion, and ion-exchange chromatography. The enzyme appeared homogeneous upon disc electrophoresis. The molecular weight of the protease... | [
-0.10601988434791565,
-0.01065940223634243,
-0.018170924857258797,
-0.01484957616776228,
0.02689065970480442,
-0.08218884468078613,
-0.011789909563958645,
0.08982141315937042,
-0.053998883813619614,
0.03890538960695267,
-0.028271527960896492,
-0.06422558426856995,
0.004242071881890297,
-0.... |
PMID:22537 | Ammonia assimilation and glutamate formation in Caulobacter crescentus. | In the dimorphic bacterium Caulobacter crescentus, ammonia assimilation occurs only via the combined action of the enzymes glutamine synthetase and glutamate synthase. Mutants auxotrophic for glutamate lacked glutamate synthase activity, and the mutations leading to the glutamate auxotrophy appeared to lie at two disti... | Ammonia assimilation and glutamate formation in Caulobacter crescentus. In the dimorphic bacterium Caulobacter crescentus, ammonia assimilation occurs only via the combined action of the enzymes glutamine synthetase and glutamate synthase. Mutants auxotrophic for glutamate lacked glutamate synthase activity, and the mu... | [
-0.009733392857015133,
-0.004796962719410658,
-0.0526617169380188,
-0.004188774153590202,
0.04860355332493782,
-0.002065894426777959,
0.00041219338891096413,
-0.01334503386169672,
-0.045472562313079834,
0.052533309906721115,
0.020485999062657356,
-0.0902499184012413,
0.07654757797718048,
0... |
PMID:22538 | Purification and properties of nitroalkane oxidase from Fusarium oxysporum. | A nitroalkane-oxidizing enzyme, which was inducibly formed by addition of nitroethane to the medium was purified to homogeneity from an extract of Fusarium oxysporum (IFO 5942) with an overall yield of about 20%. The enzyme catalyzed the oxidative denitrification of 1-nitropropane as follows: CH2(NO2)CH2CH3 + O2 + H2O ... | Purification and properties of nitroalkane oxidase from Fusarium oxysporum. A nitroalkane-oxidizing enzyme, which was inducibly formed by addition of nitroethane to the medium was purified to homogeneity from an extract of Fusarium oxysporum (IFO 5942) with an overall yield of about 20%. The enzyme catalyzed the oxidat... | [
-0.08759574592113495,
0.0018568927189335227,
-0.06834910064935684,
-0.012714213691651821,
0.06198645383119583,
-0.017022574320435524,
0.00754990428686142,
0.04796648398041725,
-0.030444180592894554,
-0.01602085866034031,
-0.020477090030908585,
-0.0752597376704216,
-0.004814543761312962,
-0... |
PMID:22539 | Association-dissociation of the flavoprotein hog kidney D-amino acid oxidase. Determination of the monomer-dimer equilibrium constant and the energetics of subunit association. | The enzyme concentration dependence of spectrophotometric titrations of hog kidney D-amino acid oxidase [EC 1.4.3.3] with p-aminobenzoate was studied. The monomer-dimer equilibrium constant of the oxidized holoenzyme at 25 degrees C was estimated to be 7 X 10(5)M-1 at pH 7.5 and 4X 10(6)M-1 at pH 8.3. The energetics of... | Association-dissociation of the flavoprotein hog kidney D-amino acid oxidase. Determination of the monomer-dimer equilibrium constant and the energetics of subunit association. The enzyme concentration dependence of spectrophotometric titrations of hog kidney D-amino acid oxidase [EC 1.4.3.3] with p-aminobenzoate was s... | [
-0.10886557400226593,
0.008108710870146751,
-0.03380183130502701,
0.019603293389081955,
0.007225183770060539,
-0.018959172070026398,
0.08866286277770996,
0.016593284904956818,
0.011320025660097599,
-0.009476914070546627,
0.0275112371891737,
-0.10569971799850464,
0.0832061693072319,
0.04028... |
PMID:22540 | Light-induced pH changes and changes in absorbance of pH indicators in Rhodospirillum rubrum chromatophores. | 1. The light-induced pH change of chromatophore suspensions from Rhodospirillum rubrum was stimulated significantly and similarly by KCl, NaCl, LiCl, RbCl, CsCl, MgCl2, MnCl2, and CaCl2. In the dark, the pH of chromatophore suspensions decreased immediately and markedly on adding these salts. 2. The light-induced pH ch... | Light-induced pH changes and changes in absorbance of pH indicators in Rhodospirillum rubrum chromatophores. 1. The light-induced pH change of chromatophore suspensions from Rhodospirillum rubrum was stimulated significantly and similarly by KCl, NaCl, LiCl, RbCl, CsCl, MgCl2, MnCl2, and CaCl2. In the dark, the pH of c... | [
-0.0514712817966938,
-0.04081743210554123,
-0.01024514902383089,
0.053162477910518646,
0.07955302298069,
-0.04948046803474426,
0.02707790955901146,
0.015423172153532505,
-0.06659786403179169,
-0.009973232634365559,
0.05464824289083481,
-0.05314154550433159,
0.017484785988926888,
0.02820454... |
PMID:22543 | Calf liver nuclear N-acetyltransferases. Purification and properties of two enzymes with both spermidine acetyltransferase and histone acetyltransferase activities. | Calf liver contains two nuclear N-acetyltransferases which are separated by chromatography on hydroxylapatite. Both acetyltransferase A and acetyltransferase B will transfer acetate from acetyl-CoA to either histone or spermidine. The same protein catalyzes the reaction with both substrates; this is shown by a constant... | Calf liver nuclear N-acetyltransferases. Purification and properties of two enzymes with both spermidine acetyltransferase and histone acetyltransferase activities. Calf liver contains two nuclear N-acetyltransferases which are separated by chromatography on hydroxylapatite. Both acetyltransferase A and acetyltransfera... | [
-0.03634806349873543,
-0.0232040174305439,
-0.05502645671367645,
-0.03462368994951248,
-0.03842718526721001,
0.012887666001915932,
0.05875259265303612,
0.04119851067662239,
-0.03696935251355171,
-0.007016083225607872,
0.03263869881629944,
-0.1003318578004837,
0.031404685229063034,
-0.03594... |
PMID:22545 | Tyrosine hydroxylase. Activation by protein phosphorylation and end product inhibition. | Protein phosphorylation activates tyrosine hydroxylase in crude extracts of rat striatum, hypothalamus, and adrenal glands by a reduction in the apparent Km value for 6-methyltetrahydropterin. Removal of endogenous catecholamines by gel filtration or cation exchange results in a similar activation. Phosphorylation caus... | Tyrosine hydroxylase. Activation by protein phosphorylation and end product inhibition. Protein phosphorylation activates tyrosine hydroxylase in crude extracts of rat striatum, hypothalamus, and adrenal glands by a reduction in the apparent Km value for 6-methyltetrahydropterin. Removal of endogenous catecholamines by... | [
-0.042921870946884155,
0.008356045000255108,
-0.005212847609072924,
0.0480087473988533,
-0.05201651528477669,
-0.026395151391625404,
0.09179117530584335,
0.012186365202069283,
-0.03375927731394768,
-0.00983657967299223,
0.055773381143808365,
-0.06092093139886856,
-0.027016282081604004,
0.0... |
PMID:22546 | Oxalate and spin-labeled oxalate as probes of the anion binding site of human transferrin. Metal to anion distance. | The spin-labeled anion N-[4-(2,2,6,6-tetramethylpiperidin-1-oxyl)] oxamate has been synthesized and characterized. In the presence of this compound, a specific iron-transferrin-anion complex is formed, as evidenced by the development of a characteristic red color. No EPR signal was observed for the nitroxyl radical in ... | Oxalate and spin-labeled oxalate as probes of the anion binding site of human transferrin. Metal to anion distance. The spin-labeled anion N-[4-(2,2,6,6-tetramethylpiperidin-1-oxyl)] oxamate has been synthesized and characterized. In the presence of this compound, a specific iron-transferrin-anion complex is formed, as... | [
-0.07907851785421371,
0.02241392247378826,
-0.05036124587059021,
0.021000012755393982,
0.020464349538087845,
-0.018259605392813683,
0.08199384808540344,
0.014500926248729229,
-0.09224577993154526,
-0.023603148758411407,
0.040348101407289505,
-0.08956123888492584,
0.0026679635047912598,
0.0... |
PMID:22547 | Quaternary states of methemoglobin and its valence-hybrid. A pulse radiolysis study. | Using the pulse radiolysis technique on solutions of stripped adult human methemoglobin, we found that the heme-iron within a single subunit in the tetramer was reduced to iron(II). The valence-hybrid thus formed was reacted with oxygen and with carbon monoxide. Kinetics of the reactions were studied. The effects of pH... | Quaternary states of methemoglobin and its valence-hybrid. A pulse radiolysis study. Using the pulse radiolysis technique on solutions of stripped adult human methemoglobin, we found that the heme-iron within a single subunit in the tetramer was reduced to iron(II). The valence-hybrid thus formed was reacted with oxyge... | [
-0.11032319813966751,
0.08366458117961884,
-0.002443864941596985,
-0.008933065459132195,
0.01556684635579586,
-0.032778263092041016,
0.07597337663173676,
-0.016427990049123764,
-0.07584711164236069,
-0.0019188043661415577,
0.03109138086438179,
-0.07391981035470963,
-0.04503292590379715,
0.... |
PMID:22549 | Increase in hepatic tyrosine aminotransferase mRNA during enzyme induction by N6,O2'-dibutyryl cyclic AMP. | Tyrosine aminotransferase mRNA was quantitated by translation in a cell-free system derived from wheat germ followed by specific immunoprecipitation of the newly synthesized enzyme subunit. Hepatic poly(A)-containg RNA prepared from rats treated for 4 h with N6, O2'-dibutyryl cyclic AMP and theophylline was approximate... | Increase in hepatic tyrosine aminotransferase mRNA during enzyme induction by N6,O2'-dibutyryl cyclic AMP. Tyrosine aminotransferase mRNA was quantitated by translation in a cell-free system derived from wheat germ followed by specific immunoprecipitation of the newly synthesized enzyme subunit. Hepatic poly(A)-contain... | [
-0.013739267364144325,
0.008592207916080952,
-0.03332946449518204,
0.014731424860656261,
0.014652741141617298,
0.029491892084479332,
0.010683326981961727,
0.03999757021665573,
-0.0575292631983757,
-0.019478943198919296,
0.03547707572579384,
-0.05930193141102791,
-0.021665651351213455,
0.01... |
PMID:22550 | Molecular weights of aggregation states of Busycon hemocyanin. | Molecular weights of all hemocyanin aggregates which can be homogeneously isolated have been measured by sedimentation equilibrium. The larger aggregates, which are the ones present under physiological conditions, are, to a very close approximation, integral multiples of a 4.4 x 10(6)-dalton, 60 S species. Dissociation... | Molecular weights of aggregation states of Busycon hemocyanin. Molecular weights of all hemocyanin aggregates which can be homogeneously isolated have been measured by sedimentation equilibrium. The larger aggregates, which are the ones present under physiological conditions, are, to a very close approximation, integra... | [
-0.10286039859056473,
-0.035767730325460434,
-0.006348731461912394,
-0.022373028099536896,
-0.03593054786324501,
-0.003375101136043668,
0.07640406489372253,
0.010523475706577301,
-0.028538160026073456,
0.00930949579924345,
0.037585046142339706,
-0.06468506157398224,
0.05067833885550499,
0.... |
PMID:22551 | The inhibition by 6-diazo-5-oxo-l-norleucine of glutamine catabolism of the cultured human lymphoblast. | The rapid catabolism of glutamine by the cultured human lymphoblast line WI-L2 can be inhibited greater than 95% by incubation of cell suspensions with 6-diazo-5-oxo-L-norleucine (DON). The inhibition persists for at least four hours after removal of DON from the cell suspension. The exposure of cells to DON ihibits ov... | The inhibition by 6-diazo-5-oxo-l-norleucine of glutamine catabolism of the cultured human lymphoblast. The rapid catabolism of glutamine by the cultured human lymphoblast line WI-L2 can be inhibited greater than 95% by incubation of cell suspensions with 6-diazo-5-oxo-L-norleucine (DON). The inhibition persists for at... | [
-0.015845205634832382,
0.005344538018107414,
0.0006550634861923754,
0.0055669015273451805,
0.029833849519491196,
-0.009044407866895199,
0.07870049774646759,
-0.01646151952445507,
-0.04727973788976669,
-0.07325558364391327,
0.0190008282661438,
-0.026254111900925636,
0.036856479942798615,
0.... |
PMID:22552 | Role of the vacuolar apparatus in augmented protein degradation in cultured fibroblasts. | Rat embryo fibroblasts, grown in Eagle's MEM with 10% serum, showed a rapid increase in autophagic vacuoles when placed in MEM with 0-1% serum. Concurrent with this response, degradation of cellular proteins showed a 2-fold increase. We did not find any increases in cathepsin D, beta-glucuronidase, beta-galactosidase, ... | Role of the vacuolar apparatus in augmented protein degradation in cultured fibroblasts. Rat embryo fibroblasts, grown in Eagle's MEM with 10% serum, showed a rapid increase in autophagic vacuoles when placed in MEM with 0-1% serum. Concurrent with this response, degradation of cellular proteins showed a 2-fold increas... | [
-0.022511912509799004,
-0.04473426192998886,
0.032214611768722534,
0.012973894365131855,
0.022978609427809715,
-0.0025707308668643236,
0.037423186004161835,
0.008717663586139679,
-0.026626532897353172,
-0.0189839955419302,
0.024928241968154907,
-0.08054900169372559,
0.03182320296764374,
0.... |
PMID:22553 | Lectin-mediated agglutination of amphibian embryonic cells. | Dissociated blastula cells of Xenopus laevis are agglutinated with wheat germ agglutinin (WGA), Ricinus communis agglutinin (RCA), concanavalin A (Con A) and, to a lesser extent with soya bean agglutinin (SBA). They are not agglutinated with fucose-binding protein. Neuraminidase treatment of cells enhances their agglut... | Lectin-mediated agglutination of amphibian embryonic cells. Dissociated blastula cells of Xenopus laevis are agglutinated with wheat germ agglutinin (WGA), Ricinus communis agglutinin (RCA), concanavalin A (Con A) and, to a lesser extent with soya bean agglutinin (SBA). They are not agglutinated with fucose-binding pro... | [
-0.05285356193780899,
-0.07026707381010056,
0.006121968850493431,
0.006866007577627897,
-0.013544116169214249,
-0.0350082628428936,
0.030434487387537956,
0.03052975796163082,
-0.0881909728050232,
-0.03427793085575104,
0.009158585220575333,
-0.07268957793712616,
0.010393867269158363,
0.0620... |
PMID:22554 | Studies on human alpha-lactalbumin: radioimmunoassay measurements in normal human breast and breast cancer. | A sensitive and specific radioimmunoassay for human alpha-lactalbumin, a milk protein, has been developed in order to examine the effect of prolactin on the human breast in normal and diseased states. Samples of milk from nursing mothers and from men and women with galactorrhea were found to contain milligram concentra... | Studies on human alpha-lactalbumin: radioimmunoassay measurements in normal human breast and breast cancer. A sensitive and specific radioimmunoassay for human alpha-lactalbumin, a milk protein, has been developed in order to examine the effect of prolactin on the human breast in normal and diseased states. Samples of ... | [
-0.016337020322680473,
-0.01678767055273056,
0.022252095863223076,
-0.026022497564554214,
0.04367778077721596,
-0.010374333709478378,
0.07507660239934921,
0.012203939259052277,
-0.012009195983409882,
-0.06403014063835144,
0.0250215046107769,
-0.08365107327699661,
-0.02621704712510109,
0.06... |
PMID:22555 | Inhibition of folate enzymes by sulfasalazine. | Sulfasalazine (salicylazosulfapyridine), an agent widely used for the treatment of ileitis and colitis, is also a competitive inhibitor of intestinal folate transport (1, 2). The mechanism of action of sulfasalazine remains uncertain. To further explore the mechanism of sulfasalazine action, the interaction of the drug... | Inhibition of folate enzymes by sulfasalazine. Sulfasalazine (salicylazosulfapyridine), an agent widely used for the treatment of ileitis and colitis, is also a competitive inhibitor of intestinal folate transport (1, 2). The mechanism of action of sulfasalazine remains uncertain. To further explore the mechanism of su... | [
-0.049678049981594086,
0.003275317372754216,
-0.1258397102355957,
0.04444192349910736,
-0.005987989250570536,
0.038203559815883636,
0.040108971297740936,
0.0734267309308052,
-0.04558936133980751,
-0.0671965628862381,
0.04977848753333092,
-0.052696406841278076,
0.012704026885330677,
0.00122... |
PMID:22556 | Effect of proteolytic enzymes on the binding of cobalamin to R protein and intrinsic factor. In vitro evidence that a failure to partially degrade R protein is responsible for cobalamin malabsorption in pancreatic insufficiency. | Cobalamin (Cbl; vitamin B(12)) malabsorption in pancreatic insufficiency can be partially corrected by bicarbonate and completely corrected by pancreatic proteases but the mechanisms involved are unknown. Because saliva contains enough R-type Cbl-binding protein (R protein) to bind all of the dietary and biliary Cbl, i... | Effect of proteolytic enzymes on the binding of cobalamin to R protein and intrinsic factor. In vitro evidence that a failure to partially degrade R protein is responsible for cobalamin malabsorption in pancreatic insufficiency. Cobalamin (Cbl; vitamin B(12)) malabsorption in pancreatic insufficiency can be partially c... | [
-0.06364762783050537,
-0.01958993449807167,
-0.054035112261772156,
0.03274165838956833,
0.013110321015119553,
-0.04738331213593483,
0.07232248038053513,
0.0329437293112278,
-0.009043511003255844,
-0.006704321596771479,
-0.006192323751747608,
-0.11123736947774887,
0.015431161038577557,
0.05... |
PMID:22569 | Comparison of the ribonucleoproteins of different rabies virus serotypes by radioimmunoassay. | Radioimmunoassay (RIA) provides a sensitive serological procedure for detecting rabies virus ribonucleoprotein (RNP) as well as its specific antibodies, RIA was carried out using highly purified RNPs labelled by the chloramine-T method. This paper describes optimal conditions for iodination of RNP with high specific ac... | Comparison of the ribonucleoproteins of different rabies virus serotypes by radioimmunoassay. Radioimmunoassay (RIA) provides a sensitive serological procedure for detecting rabies virus ribonucleoprotein (RNP) as well as its specific antibodies, RIA was carried out using highly purified RNPs labelled by the chloramine... | [
-0.0373794287443161,
0.0050742109306156635,
-0.00869494117796421,
-0.04224344342947006,
0.07959826290607452,
-0.026727216318249702,
0.0607452355325222,
0.06320592761039734,
-0.0391121581196785,
-0.015153372660279274,
0.025542186573147774,
-0.0637885108590126,
0.020339345559477806,
0.018868... |
PMID:22573 | A simple method to determine gammaglutamyl-cyclotransferase activity in erythrocytes. | A new method for the determination of erythrocyte gammaGCT is described. The method follows the release of alanine from gammaglutamyl alanine by a series of linked reactions that result in the oxidation of NADH to NAD. The pH optimum for human erythrocyte gammaGCT was found to be 9.0, and the Km for gammaglutamyl alani... | A simple method to determine gammaglutamyl-cyclotransferase activity in erythrocytes. A new method for the determination of erythrocyte gammaGCT is described. The method follows the release of alanine from gammaglutamyl alanine by a series of linked reactions that result in the oxidation of NADH to NAD. The pH optimum ... | [
-0.03116142936050892,
-0.001123345224186778,
-0.03123309276998043,
0.023218590766191483,
0.037515271455049515,
-0.011047055944800377,
0.03989186882972717,
0.047202613204717636,
-0.0380101352930069,
-0.0022514283191412687,
-0.0021302185487002134,
-0.058289337903261185,
-0.0714619979262352,
... |
PMID:22574 | Hyperlipidemia in renal failure: studies of plasma lipoproteins, hepatic triglyceride production, and tissue lipoprotein lipase in a chronically uremic rat moedl. | To determine whether hypertriglyceridemia in chronic renal failure resulted from altered production and/or removal, Sprague-Dawley rats in which chronic uremia had been induced by five-sixths nephrectomy were studied. In this model, basal plasma TG levels were higher than in controls (uremic 141 +/- 52 mg/100 ml; contr... | Hyperlipidemia in renal failure: studies of plasma lipoproteins, hepatic triglyceride production, and tissue lipoprotein lipase in a chronically uremic rat moedl. To determine whether hypertriglyceridemia in chronic renal failure resulted from altered production and/or removal, Sprague-Dawley rats in which chronic urem... | [
-0.02442590519785881,
0.035637784749269485,
-0.0069637722335755825,
0.05254044383764267,
0.012259021401405334,
-0.009395106695592403,
0.041765857487916946,
0.07200140506029129,
-0.050766658037900925,
-0.00623320834711194,
0.02283165417611599,
-0.07847318053245544,
0.038462042808532715,
-0.... |
PMID:22576 | Cholesterol ester hydrolysis by homogenates of whole testis, seminiferous tubules and interstitial cells of mature rats. | The characteristics and localization of a cholesterol ester hydrolase enzyme in homogenates of whole testis and in isolated seminiferous tubules and interstitial cells of mature rats have been investigated. Hydrolysis of cholesteryl [1(-14)C]oleate occurred at an optimum pH of 7.0, was linearly related to time up to 5-... | Cholesterol ester hydrolysis by homogenates of whole testis, seminiferous tubules and interstitial cells of mature rats. The characteristics and localization of a cholesterol ester hydrolase enzyme in homogenates of whole testis and in isolated seminiferous tubules and interstitial cells of mature rats have been invest... | [
0.0026149367913603783,
0.016338912770152092,
-0.060843419283628464,
-0.006770235486328602,
-0.01218400802463293,
0.0035620105918496847,
0.0004043215012643486,
0.034845829010009766,
0.003107445314526558,
-0.026883626356720924,
0.016482524573802948,
-0.09346811473369598,
0.014129235409200191,
... |
PMID:22579 | Energetics of biological nitrogen fixation: determination of the ratio of formation of H2 to NH4+ catalysed by nitrogenase of Klebsiella pneumoniae in vivo. | Nitrogen fixation (Nif)-derepressed mutants of Klebsiella pneumoniae consumed, under optimum conditions, 7.5 to 8.5 mol glucose per mol N2 fixed. The nitrogenase system of these mutants catalysed the production of about 1.3 mol H2 per mol N2 reduced. Almost one-third of the energy as ATP and reductant used by nitrogena... | Energetics of biological nitrogen fixation: determination of the ratio of formation of H2 to NH4+ catalysed by nitrogenase of Klebsiella pneumoniae in vivo. Nitrogen fixation (Nif)-derepressed mutants of Klebsiella pneumoniae consumed, under optimum conditions, 7.5 to 8.5 mol glucose per mol N2 fixed. The nitrogenase s... | [
-0.0771126076579094,
0.035768743604421616,
-0.02746116742491722,
0.014839435927569866,
0.08585386723279953,
-0.010691315867006779,
0.0010998154757544398,
0.01704913191497326,
-0.01768345572054386,
0.013617104850709438,
0.0018549873493611813,
-0.08920472115278244,
-0.04080001637339592,
0.02... |
PMID:22590 | Aerobic and anaerobic bacteriology of acute otitis media in children. | Tympanocentesis and aerobic and anaerobic cultivation of the middle-ear fluid obtained was performed through one or both tympanic membranes of 62 children with acute otitis media. Aerobic bacteria alone, predominantely pneumococcus and Hemophilus influenzae, were isolated from 57% of patients; anaerobic organisms alone... | Aerobic and anaerobic bacteriology of acute otitis media in children. Tympanocentesis and aerobic and anaerobic cultivation of the middle-ear fluid obtained was performed through one or both tympanic membranes of 62 children with acute otitis media. Aerobic bacteria alone, predominantely pneumococcus and Hemophilus inf... | [
-0.0025538522750139236,
0.009050169959664345,
-0.026856468990445137,
-0.00978870503604412,
0.03166625276207924,
0.006576822604984045,
-0.0047616176307201385,
0.03921695053577423,
-0.05394057556986809,
-0.013494085520505905,
0.014546096324920654,
-0.13258937001228333,
-0.004770396277308464,
... |
PMID:22591 | The pharmacologic effects of furosemide therapy in the low-birth-weight infant. | The pharmacologic effects of furosemide were studied in six infants (mean gestation 30.7 weeks; mean birth weight 1,490 gm) at ages 10 to 57 days. Furosemide (for clinical indication, standardized at 1 mg/kg) was given intravenously over one minute; data were collected over the ensuing 24 hours. For three hours followi... | The pharmacologic effects of furosemide therapy in the low-birth-weight infant. The pharmacologic effects of furosemide were studied in six infants (mean gestation 30.7 weeks; mean birth weight 1,490 gm) at ages 10 to 57 days. Furosemide (for clinical indication, standardized at 1 mg/kg) was given intravenously over on... | [
-0.01661340333521366,
-0.0031711473129689693,
-0.027920227497816086,
-0.018225086852908134,
-0.020880093798041344,
0.010814348235726357,
0.01446146983653307,
0.03462474048137665,
-0.09518596529960632,
-0.007951030507683754,
0.07891660183668137,
-0.00167454790789634,
0.03827238827943802,
0.... |
PMID:22592 | Physiologic changes induced by theophylline in the treatment of apnea in preterm infants. | Ten preterm infants (birth weight 0.970 to 2.495 kg) with apnea due to periodic breathing (apneic interval = 5 to 10 seconds) or with "serious apnea" (greater than or equal to 20 seconds) were studied before and after the administration of theophylline. We determined the incidence of apnea, respiratory minute volume, a... | Physiologic changes induced by theophylline in the treatment of apnea in preterm infants. Ten preterm infants (birth weight 0.970 to 2.495 kg) with apnea due to periodic breathing (apneic interval = 5 to 10 seconds) or with "serious apnea" (greater than or equal to 20 seconds) were studied before and after the administ... | [
-0.035418663173913956,
-0.007997468113899231,
0.03420352563261986,
0.010734280571341515,
0.02869691140949726,
0.0015962811885401607,
0.023138150572776794,
-0.007890629582107067,
-0.04864411801099777,
0.0007896903553046286,
-0.04043406620621681,
0.0068091098219156265,
-0.028968915343284607,
... |
PMID:22593 | The microfilaria of Brugia timori (Partono et al. 1977 = Timor microfilaria, David and Edeson, 1964): morphologic description with comparison to Brugia malayi of Indonesia. | The microfilaria of Brugia timori was compared with microfilariae of Indonesian strains of periodic and subperiodic Brugia malayi using alcohol-fixed (stained) and formalin-fixed (unstained) preparations. As noted by other observers of the Timor microfilaria, the absence of a stained sheath in Giemsa preparations, a lo... | The microfilaria of Brugia timori (Partono et al. 1977 = Timor microfilaria, David and Edeson, 1964): morphologic description with comparison to Brugia malayi of Indonesia. The microfilaria of Brugia timori was compared with microfilariae of Indonesian strains of periodic and subperiodic Brugia malayi using alcohol-fix... | [
0.01820002868771553,
-0.01780800335109234,
0.06397539377212524,
0.05001136660575867,
0.033299800008535385,
-0.024559175595641136,
-0.0017592915100976825,
0.05015076324343681,
-0.005254482384771109,
0.031064487993717194,
-0.027821961790323257,
-0.07503164559602737,
0.015045448206365108,
0.0... |
PMID:22594 | Total surgical reconstruction for patients with abdominal muscular deficiency ("prune-belly") syndrome. | In the past decade, seven children with the prune-belly syndrome have been seen. Their management has consisted of immediate high tubeless urinary diversion, usually pyelostomy. Thereafter, total reconstruction has been carried out, preferably at one stage. This consists of (1) bilateral shortening, tapering and reimpl... | Total surgical reconstruction for patients with abdominal muscular deficiency ("prune-belly") syndrome. In the past decade, seven children with the prune-belly syndrome have been seen. Their management has consisted of immediate high tubeless urinary diversion, usually pyelostomy. Thereafter, total reconstruction has b... | [
0.01515633799135685,
-0.03833300247788429,
0.04006538167595863,
0.034923676401376724,
-0.042776528745889664,
-0.024171344935894012,
-0.054379500448703766,
0.02375764586031437,
-0.03155176714062691,
0.010129963979125023,
0.04925290867686272,
-0.09599683433771133,
0.0043950155377388,
0.00401... |
PMID:22595 | Technique and experience with 24-hour esophageal pH monitoring in children. | The technique and scoring system of 24-hr pH esophageal monitoring has been modified to evaluate gastroesophageal reflux in infants and children. The data from two pediatric controls and five clinical cases are presented and compared to normal adult values. This test has better objectivity, precision, sensitivity, and ... | Technique and experience with 24-hour esophageal pH monitoring in children. The technique and scoring system of 24-hr pH esophageal monitoring has been modified to evaluate gastroesophageal reflux in infants and children. The data from two pediatric controls and five clinical cases are presented and compared to normal ... | [
0.012699993327260017,
-0.005633075721561909,
0.02211044356226921,
0.01731634885072708,
0.0198548324406147,
-0.06860318034887314,
0.034062355756759644,
0.043120790272951126,
-0.06013543903827667,
0.001889386330731213,
0.006452052388340235,
-0.07987108081579208,
-0.01991664245724678,
0.04696... |
PMID:22596 | Physostigmine's effect on diminished fetal heart rate variability caused by scopolamine, meperidine and propiomazine. | Physostigmine was given to 17 patients in labor, previously given scopolamine alone or meperidine and propiomazine in combination, to ascertain its effect on reversing the loss of fetal heart rate variability caused by the administration of these drugs. The results of the study indicated that scopolamine in doses of 0.... | Physostigmine's effect on diminished fetal heart rate variability caused by scopolamine, meperidine and propiomazine. Physostigmine was given to 17 patients in labor, previously given scopolamine alone or meperidine and propiomazine in combination, to ascertain its effect on reversing the loss of fetal heart rate varia... | [
-0.04082542285323143,
0.029459038749337196,
-0.04913591966032982,
0.05798715725541115,
-0.03759550303220749,
-0.00020843849051743746,
0.02748788334429264,
0.021107854321599007,
-0.03413836285471916,
-0.05084185302257538,
-0.02057417668402195,
0.022482633590698242,
-0.013157043606042862,
0.... |
PMID:22598 | The influence of adrenalectomy on monoamine oxidase and NADH cytochrome c reductase in the rat heart. | The effect of adrenalectomy on the activities of monoamine oxidase (MAO), NADH cytochrome c reductase (NCR), succinate dehydrogenase, malate dehydrogenase, fumarase, NAD+ nucleosidase and acid phosphatase in homogenates of rat hearts was examined. Besides MAO only the NCR activity increased. However, both the total and... | The influence of adrenalectomy on monoamine oxidase and NADH cytochrome c reductase in the rat heart. The effect of adrenalectomy on the activities of monoamine oxidase (MAO), NADH cytochrome c reductase (NCR), succinate dehydrogenase, malate dehydrogenase, fumarase, NAD+ nucleosidase and acid phosphatase in homogenate... | [
-0.02443782053887844,
0.028987476602196693,
-0.03558241203427315,
0.08797997236251831,
0.02207733504474163,
-0.01566784828901291,
0.07860786467790604,
0.004003270994871855,
-0.05156075209379196,
-0.07292988151311874,
0.01273259799927473,
-0.009510732255876064,
0.006439610850065947,
0.04932... |
PMID:22600 | The effect of metyrapone on granuloma induced by carrageenan-impregnated sponges in normal and essential fatty acid deficient rats. | Treatment of normal rats with metyrapone (20 mg kg-1 day-1, s.c.) for 5 days, starting on the day before implantation, inhibited the production of granuloma, induced by carrageenan-impregnated sponges, determined 8 days after implantation. Exudate volume and prostaglandin (PG) production were unaffected. In essential f... | The effect of metyrapone on granuloma induced by carrageenan-impregnated sponges in normal and essential fatty acid deficient rats. Treatment of normal rats with metyrapone (20 mg kg-1 day-1, s.c.) for 5 days, starting on the day before implantation, inhibited the production of granuloma, induced by carrageenan-impregn... | [
-0.004259767476469278,
0.026751700788736343,
0.041903164237737656,
0.02711881510913372,
0.01279278565198183,
-0.002608983777463436,
-0.019473468884825706,
-0.00769413635134697,
-0.08302095532417297,
-0.023600099608302116,
0.04716243967413902,
-0.021043851971626282,
0.041474126279354095,
0.... |
PMID:22601 | Platelets in inflammatory exudates. | In exudates of implanted sponges in the rat there are apparent accumulations of blood platelets, assessed by the light microscope, and of radioactivity from labelled platelets administered systemically. The use of more specific techniques for platelet detection showed no evidence of intact blood platelets in the exudat... | Platelets in inflammatory exudates. In exudates of implanted sponges in the rat there are apparent accumulations of blood platelets, assessed by the light microscope, and of radioactivity from labelled platelets administered systemically. The use of more specific techniques for platelet detection showed no evidence of ... | [
-0.01297372579574585,
0.030013129115104675,
0.012275693006813526,
-0.03759006783366203,
0.016311122104525566,
-0.04998493567109108,
0.0666060596704483,
0.05664527788758278,
-0.06271173804998398,
0.0480845645070076,
0.03596832603216171,
-0.05848284810781479,
0.014763012528419495,
0.06283184... |
PMID:22603 | Estimation of the degree of crystallinity in digoxin by X-ray and infrared methods. | The X-ray procedure for estimation of the degree of crystallinity in digoxin is based upon measurement of the total X-ray scattering and the scattering from crystalline regions of the drug. The infrared procedures are based upon measurement of the peak height ratios, 1775/1618 and 3095/1618 cm-1. Correlation between re... | Estimation of the degree of crystallinity in digoxin by X-ray and infrared methods. The X-ray procedure for estimation of the degree of crystallinity in digoxin is based upon measurement of the total X-ray scattering and the scattering from crystalline regions of the drug. The infrared procedures are based upon measure... | [
-0.05380756035447121,
0.014827956445515156,
0.09126974642276764,
-0.03286260366439819,
0.034194301813840866,
0.0699538141489029,
0.010967486537992954,
0.01020556315779686,
-0.05839121714234352,
-0.045580003410577774,
0.0028327612672001123,
-0.05875449255108833,
0.056272219866514206,
0.0356... |
PMID:22604 | The effect of composition and ageing on the dissolution rates of chlorpropamide-urea solid dispersions. | Discs of chlorpropamide and urea have been prepared by (a) melting and (b) compression. Intrinsic and relative dissolution rates of the discs have been measured and the dissolution process investigated microscopically. Higher dissolution rates were found from melts than from physical mixes. The optimum dissolution rate... | The effect of composition and ageing on the dissolution rates of chlorpropamide-urea solid dispersions. Discs of chlorpropamide and urea have been prepared by (a) melting and (b) compression. Intrinsic and relative dissolution rates of the discs have been measured and the dissolution process investigated microscopicall... | [
-0.04334476217627525,
-0.0268281027674675,
0.01560726948082447,
-0.025966329500079155,
0.02027725987136364,
0.03679927811026573,
-0.028478918597102165,
0.030126649886369705,
-0.04402528703212738,
-0.01613360457122326,
0.010251886211335659,
-0.03607267886400223,
0.03565582260489464,
0.03980... |
PMID:22616 | Loss of antibacterial preservatives from contact lens solutions during storage. | The preservative content of 34 commercially available contact lens solutions has been determined. Over half of the solutions contained less than 90% of the stated preservative content. Storage tests conducted at 40 degrees, using both simulated and commercially available contact lens solutions in plastics containers of... | Loss of antibacterial preservatives from contact lens solutions during storage. The preservative content of 34 commercially available contact lens solutions has been determined. Over half of the solutions contained less than 90% of the stated preservative content. Storage tests conducted at 40 degrees, using both simul... | [
-0.06645429879426956,
0.038089558482170105,
0.0011817372869700193,
0.02353024110198021,
0.07097697257995605,
-0.0005223337793722749,
0.06779102236032486,
0.0311915073543787,
-0.10786186158657074,
-0.0034523867070674896,
-0.04419314116239548,
-0.04879719763994217,
0.05367206409573555,
0.031... |
PMID:22617 | The adhesion of film coatings to tablet surfaces--the effect of some direct compression excipients and lubricants. | The effect of some direct compression excipients and lubricants on the adhesion of hydroxypropyl methyl cellulose films has been examined using a specially designed tensile testing apparatus (Fisher & Rowe, 1976). The adhesion was found to be influenced by both the roughness, including microporosity, of the tablet ... | The adhesion of film coatings to tablet surfaces--the effect of some direct compression excipients and lubricants. The effect of some direct compression excipients and lubricants on the adhesion of hydroxypropyl methyl cellulose films has been examined using a specially designed tensile testing apparatus (Fisher & ... | [
-0.07710862904787064,
0.03435490280389786,
0.024305369704961777,
-0.02714303880929947,
0.012553581967949867,
-0.01939292810857296,
-0.014321248047053814,
0.021686986088752747,
-0.05653911828994751,
-0.04940560460090637,
-0.007576503790915012,
-0.01129928044974804,
0.019095901399850845,
0.0... |
PMID:22619 | The effects of p-chlorophenylalanine and ethanolamine-O-sulphate in an animal test of anxiety. | p-Chlorophenylalanine, which produces a depletion of brain 5-HT concentration, had effects qualitatively similar to those previously found with chronic chlordiazepoxide and with acute ethanol in the social interaction test of anxiety. This result is compatible with the idea that a reduced turnover of 5-HT is important ... | The effects of p-chlorophenylalanine and ethanolamine-O-sulphate in an animal test of anxiety. p-Chlorophenylalanine, which produces a depletion of brain 5-HT concentration, had effects qualitatively similar to those previously found with chronic chlordiazepoxide and with acute ethanol in the social interaction test of... | [
-0.02951584756374359,
0.0366060733795166,
0.0020586992613971233,
0.03748898208141327,
-0.021496590226888657,
0.07596038281917572,
0.07169194519519806,
0.05947737768292427,
-0.024703431874513626,
-0.049735769629478455,
0.01878552883863449,
-0.024157537147402763,
-0.00505392299965024,
0.0716... |
PMID:22621 | Renal clearance procedure for the rat: effect of dopamine and standard saluretics. | Four standard diuretic compounds were evaluated for electrolyte output, effects on glomerular filtration rate (GFR), and effective renal plasma flow (RPF) in an anaesthetized rat preparation. Triamterene, hydrochlorothiazide, acetazoleamide and furosemide exerted their characteristic diuretic effects at doses which did... | Renal clearance procedure for the rat: effect of dopamine and standard saluretics. Four standard diuretic compounds were evaluated for electrolyte output, effects on glomerular filtration rate (GFR), and effective renal plasma flow (RPF) in an anaesthetized rat preparation. Triamterene, hydrochlorothiazide, acetazoleam... | [
-0.00892117153853178,
-0.000320122780976817,
0.014503886923193932,
0.007850343361496925,
-0.00617454806342721,
0.007519053295254707,
0.04740603640675545,
0.027777040377259254,
-0.08713620901107788,
-0.04467519372701645,
-0.008263393305242062,
-0.01673411950469017,
0.028070352971553802,
0.0... |
PMID:22622 | Effect of drugs on rats exposed to cold--restraint stress. | The extent of protection afforded by over 40 drugs of various pharmacological groups against the development of gastric erosions induced in rats by a combination of cold and restraint has been investigated. Some drugs offered good protection, others had no effect on, or exacerbated, the lesions. Attempts are made to ex... | Effect of drugs on rats exposed to cold--restraint stress. The extent of protection afforded by over 40 drugs of various pharmacological groups against the development of gastric erosions induced in rats by a combination of cold and restraint has been investigated. Some drugs offered good protection, others had no effe... | [
-0.02412855066359043,
-0.007240938022732735,
0.07098010927438736,
0.028067799285054207,
0.027620285749435425,
0.03216852620244026,
0.11213060468435287,
0.01283767819404602,
-0.07558071613311768,
-0.08937034010887146,
-0.06257549673318863,
-0.011159855872392654,
0.0015896447002887726,
0.055... |
PMID:22623 | Effects of pulmonary metabolites of prostaglandins E2 and F2alpha on guinea-pig respiratory tract. | The effects of three pulmonary metabolites of prostaglandins E2 and F2alpha on the guinea-pig tracheal muscle in vitro and on lung resistance in vivo were investigated. Prostaglandin F2alpha, 13,14-dihydro PGF2alpha and 13,14-dihydro 15-oxo PGF2alpha produced contractions on the tracheal muscle in vitro. 15-oxo PGF2alp... | Effects of pulmonary metabolites of prostaglandins E2 and F2alpha on guinea-pig respiratory tract. The effects of three pulmonary metabolites of prostaglandins E2 and F2alpha on the guinea-pig tracheal muscle in vitro and on lung resistance in vivo were investigated. Prostaglandin F2alpha, 13,14-dihydro PGF2alpha and 1... | [
-0.06129375845193863,
-0.026409592479467392,
-0.030924707651138306,
0.008270996622741222,
0.046585939824581146,
0.045192472636699677,
0.012018195353448391,
0.026716971769928932,
-0.05070529878139496,
0.0077741085551679134,
-0.0027356294449418783,
-0.10149266570806503,
-0.01835869811475277,
... |
PMID:22624 | Identification of the in vitro N-oxidized metabolites of (+)- and (-)-N-benzylamphetamine. | This study has identified (+)- and (-)-N-benzyl-N-hydroxyamphetamine as metabolites after incubation of both (+)- and (-)-N-benzylamphetamine with fortified rabbit liver homogenates. The isomeric hydroxylamine metabolites were identified using the techniques of g.l.c., t.l.c. and combined g.l.c.-mass spectrometry (ms) ... | Identification of the in vitro N-oxidized metabolites of (+)- and (-)-N-benzylamphetamine. This study has identified (+)- and (-)-N-benzyl-N-hydroxyamphetamine as metabolites after incubation of both (+)- and (-)-N-benzylamphetamine with fortified rabbit liver homogenates. The isomeric hydroxylamine metabolites were id... | [
-0.053428225219249725,
-0.005288612563163042,
-0.018465694040060043,
0.028475606814026833,
0.03379089757800102,
0.031357284635305405,
0.02132296934723854,
-0.014328534714877605,
-0.056942082941532135,
-0.02485727146267891,
0.00005679982859874144,
-0.005845795385539532,
-0.010331084951758385,... |
PMID:22717 | Temperature dependence of the disintegration times of compressed tablets containing hydroxypropylcellulose as binder. | The dependence of the disintegration times of placebo and active tablets containing hydroxypropylcellulose (HPC), as binder on the temperature of the test medium in the region of 37 degrees is reported. The degree of temperature dependence varied with the HPC lot and concentration in the formulation of certain drugs, s... | Temperature dependence of the disintegration times of compressed tablets containing hydroxypropylcellulose as binder. The dependence of the disintegration times of placebo and active tablets containing hydroxypropylcellulose (HPC), as binder on the temperature of the test medium in the region of 37 degrees is reported.... | [
-0.07324036210775375,
0.0391060896217823,
0.04607204720377922,
-0.0219310000538826,
0.058109529316425323,
-0.005117397289723158,
0.036250412464141846,
0.01317264698445797,
-0.020330145955085754,
-0.037477921694517136,
-0.00276644853875041,
-0.0010532912565395236,
0.0275366622954607,
0.0075... |
PMID:22718 | A model for short term drug absorption studies; comparison of sulphadiazine tablets. | The four parameter equation, applicable to drug absorption kinetics over a limited time period, has been used to interpret plasma concentration, time results following oral dosage with three different formulations of sulphadiazine tablets, to each of five subjects. Assessment parameters for the formulations, the time f... | A model for short term drug absorption studies; comparison of sulphadiazine tablets. The four parameter equation, applicable to drug absorption kinetics over a limited time period, has been used to interpret plasma concentration, time results following oral dosage with three different formulations of sulphadiazine tabl... | [
-0.057302284985780716,
0.018952438607811928,
-0.008396795019507408,
-0.0007756500854156911,
0.016526712104678154,
0.02582583576440811,
0.05580257996916771,
0.03198026120662689,
-0.030163543298840523,
-0.054498862475156784,
0.003054798347875476,
-0.04358026757836342,
0.04753870517015457,
0.... |
PMID:22719 | Degradation of (--)-ephedrine in solution and during extraction with diethyl ether. | Significant losses occurred during the extraction of small quantities of ephedrine from aqueous media using either regular or analytical grades of diethyl ether. The losses were, at least in part, caused by reaction of the ephedrine with aldehydic impurities in the ether; three substituted oxazolidines were identified,... | Degradation of (--)-ephedrine in solution and during extraction with diethyl ether. Significant losses occurred during the extraction of small quantities of ephedrine from aqueous media using either regular or analytical grades of diethyl ether. The losses were, at least in part, caused by reaction of the ephedrine wit... | [
-0.055202238261699677,
0.03126773238182068,
0.03145301714539528,
-0.007144640199840069,
-0.016555069014430046,
-0.04277288168668747,
0.006197998765856028,
0.0392969474196434,
-0.07662453502416611,
0.031892079859972,
-0.02785470336675644,
-0.02957232855260372,
-0.014265444129705429,
-0.0292... |
PMID:22720 | Red cell cyanide. | The amount of cyanide released on acidifying whole blood was much greater than the total from the plasma and red cells assayed separately, and varied directly with plasma thiocyanate concentrations. This artifactual formation of cyanide by whole blood was reduced by exposure to carbon monoxide. Incubation of haemolysat... | Red cell cyanide. The amount of cyanide released on acidifying whole blood was much greater than the total from the plasma and red cells assayed separately, and varied directly with plasma thiocyanate concentrations. This artifactual formation of cyanide by whole blood was reduced by exposure to carbon monoxide. Incuba... | [
-0.07098637521266937,
0.04232816398143768,
-0.02961921878159046,
0.03971897438168526,
0.00212683854624629,
-0.022600814700126648,
0.0995621532201767,
0.050440870225429535,
-0.026750242337584496,
0.05745210871100426,
0.027406899258494377,
-0.05538089573383331,
-0.0016052136197686195,
0.0581... |
PMID:22721 | Changes in muscarinic ligand binding to intestinal muscle strips produced by pre-exposure to hypotonic conditions. | The extent of the binding of [3H]propylbenzilylcholine mustard (3H-PrBCM) to muscarinic receptors in longitudinal muscle strips from guinea-pig small intestine is increased by nearly 50% when the strips are preexposed to distilled water before measurement of 3H-PrBCM binding in Krebs-Henseleit solution. The apparent ra... | Changes in muscarinic ligand binding to intestinal muscle strips produced by pre-exposure to hypotonic conditions. The extent of the binding of [3H]propylbenzilylcholine mustard (3H-PrBCM) to muscarinic receptors in longitudinal muscle strips from guinea-pig small intestine is increased by nearly 50% when the strips ar... | [
-0.04895124211907387,
-0.023291828110814095,
0.020769815891981125,
0.03745430335402489,
-0.020089376717805862,
-0.03189164772629738,
0.015053968876600266,
-0.00994390994310379,
-0.012785136699676514,
-0.024639839306473732,
0.015677476301789284,
-0.07412540912628174,
-0.008713892661035061,
... |
PMID:22722 | Modification by monoamine oxidase inhibitors of the analgesic, hypothermic and toxic actions of morphine and pethidine in mice. | A single injection of phenelzine 100 mg kg-1 given 18 h before, decreased the analgesia and hypothermia induced by morphine, but potentiated the analgesic and hypothermic effects of pethidine, when the analgesics were administered either intraperitoneally, or intracerebroventricularly. The modification of pethidine ana... | Modification by monoamine oxidase inhibitors of the analgesic, hypothermic and toxic actions of morphine and pethidine in mice. A single injection of phenelzine 100 mg kg-1 given 18 h before, decreased the analgesia and hypothermia induced by morphine, but potentiated the analgesic and hypothermic effects of pethidine,... | [
-0.04826676845550537,
0.029244355857372284,
0.011223621666431427,
0.03731413930654526,
0.022277388721704483,
0.008426533080637455,
0.08225735276937485,
0.016650846228003502,
-0.04305431991815567,
0.004275579005479813,
-0.0153966024518013,
-0.0173823032528162,
0.015736395493149757,
0.063371... |
PMID:22723 | Delay of castor oil diarrhoea in rats: a new way to evaluate inhibitors of prostaglandin biosynthesis. | Forty-four non-steroidal anti-inflammatory compounds were tested for possible effects on castor oil-induced diarrhoea in rats. A small but significant delay of intestinal evacuations was found with all compounds. Quantitatively, the oral doses required to delay diarrhoea beyond the first hour after castor oil challenge... | Delay of castor oil diarrhoea in rats: a new way to evaluate inhibitors of prostaglandin biosynthesis. Forty-four non-steroidal anti-inflammatory compounds were tested for possible effects on castor oil-induced diarrhoea in rats. A small but significant delay of intestinal evacuations was found with all compounds. Quan... | [
-0.06942103058099747,
0.00042621069587767124,
-0.00038025155663490295,
0.001894372166134417,
-0.0025791379157453775,
-0.0003507351502776146,
0.00454699294641614,
0.03890594094991684,
-0.07188715785741806,
-0.028183799237012863,
0.06680377572774887,
-0.02900291234254837,
0.041734423488378525,... |
PMID:22731 | Particle slippage and rearrangement during compression of pharmaceutical powders. | Compression data from different size fractions of lactose, chloroquine diphosphate, stearic acid and calcium carbonate have been analysed using the Walker and the Heckel compression equations. Points of inflection in graphs of log applied pressure vs the reciprocal of the packing fraction at low pressures corresponded ... | Particle slippage and rearrangement during compression of pharmaceutical powders. Compression data from different size fractions of lactose, chloroquine diphosphate, stearic acid and calcium carbonate have been analysed using the Walker and the Heckel compression equations. Points of inflection in graphs of log applied... | [
-0.06241615116596222,
0.007521859370172024,
0.035757072269916534,
-0.03259037062525749,
0.037683043628931046,
0.018920084461569786,
0.02147166058421135,
-0.0058718412183225155,
-0.0489225760102272,
-0.028616392984986305,
-0.047495242208242416,
-0.03750517591834068,
0.028676889836788177,
0.... |
PMID:22737 | Solid dispersions of nitrofurantoin, ethotoin, and coumarin with polyethylene glycol 6000 and their coprecipitates with providone 25,000. | The influence of two linear polymers, polyethylene glycol 6000 and povidone 25,000, on the dissolution rate of three poorly soluble drugs, nitrofurantoin, ethotoin, and coumarin, was studied. Povidone 25,000 produced better drug solubilization than polyethylene glycol 6000 with the drug-polymer ratios studied, and an i... | Solid dispersions of nitrofurantoin, ethotoin, and coumarin with polyethylene glycol 6000 and their coprecipitates with providone 25,000. The influence of two linear polymers, polyethylene glycol 6000 and povidone 25,000, on the dissolution rate of three poorly soluble drugs, nitrofurantoin, ethotoin, and coumarin, was... | [
-0.06608271598815918,
-0.010186159051954746,
0.02461959607899189,
-0.04959189519286156,
0.030513862147927284,
-0.039111118763685226,
-0.020714424550533295,
0.02086665853857994,
-0.0671459287405014,
-0.013163448311388493,
-0.03418910503387451,
0.002342705149203539,
0.026887837797403336,
0.0... |
PMID:22738 | General method for determining macrodissociation constants of polyprotic, amphoteric compounds from solubility measurements. | Equilibrium solubility and pH measurements can be used to determine macrodissociation constants of weak acids and bases of some highly insoluble substances. Equations are derived extending solubility, pH, and pKa (macroscopic) relationships to polyprotic, amphoteric substances. A general method for estimating pKa value... | General method for determining macrodissociation constants of polyprotic, amphoteric compounds from solubility measurements. Equilibrium solubility and pH measurements can be used to determine macrodissociation constants of weak acids and bases of some highly insoluble substances. Equations are derived extending solubi... | [
-0.05068446695804596,
0.000863555003888905,
0.000511884456500411,
-0.020892200991511345,
0.006983327679336071,
-0.006907476112246513,
0.010823260061442852,
0.016420364379882812,
-0.05473361536860466,
0.00785804633051157,
0.050504397600889206,
-0.06994515657424927,
0.04693169146776199,
-0.0... |
PMID:22739 | l-Bunolol and propranolol: oral and intravenous beta-adrenoceptor blocking activity in rats compared to dogs and humans. | To determine the pharmacological significance of reported differences between species in l-bunolol metabolism, oral and intravenous beta-adrenoceptor blocking activity against an isoproterenol-induced tachycardia was compared in dogs, rats, and humans. Propranolol was similarly studied in rats and dogs. Species differe... | l-Bunolol and propranolol: oral and intravenous beta-adrenoceptor blocking activity in rats compared to dogs and humans. To determine the pharmacological significance of reported differences between species in l-bunolol metabolism, oral and intravenous beta-adrenoceptor blocking activity against an isoproterenol-induce... | [
-0.017057927325367928,
-0.050131794065237045,
0.01470352616161108,
0.010138766840100288,
0.0601511113345623,
-0.03281198441982269,
0.0356534868478775,
0.011048215441405773,
-0.037368349730968475,
-0.06278816610574722,
0.01626250147819519,
-0.03136225417256355,
0.009780153632164001,
0.02804... |
PMID:22740 | Stability of tetrahydrocannabinols II. | The biphasic degradation of delta9-tetrahydrocannabinol (I), as monitored by flame-ionization GLC, produced delta8-tetrahydrocannabinol (II), cannabidiol (X), 9-hydroxyhexahydrocannabinol (VI), 9,10-dihydro-9-hydroxyisocannabidiol (VI), and and 6,12-dihydro-6-hydroxycannabidiol (VIII) in acidic solutions. Further ident... | Stability of tetrahydrocannabinols II. The biphasic degradation of delta9-tetrahydrocannabinol (I), as monitored by flame-ionization GLC, produced delta8-tetrahydrocannabinol (II), cannabidiol (X), 9-hydroxyhexahydrocannabinol (VI), 9,10-dihydro-9-hydroxyisocannabidiol (VI), and and 6,12-dihydro-6-hydroxycannabidiol (V... | [
-0.04330170154571533,
-0.029115455225110054,
-0.03155164793133736,
-0.043930534273386,
0.04431445151567459,
0.006814018357545137,
0.014619875699281693,
-0.037398599088191986,
-0.0575828030705452,
0.022999057546257973,
-0.010899675078690052,
-0.07271674275398254,
0.03934076428413391,
-0.001... |
PMID:22741 | The pH of brain extracellular fluid in the cat. | 1. The blood supply to the medulla was determined by the injection of indian ink via the vertebral arteries. Virtually the whole medulla was supplied by penetrating vessels from the ventral surface. The highest density of small arterioles and venules was found close to the roots of XII and on the ventrolateral surface.... | The pH of brain extracellular fluid in the cat. 1. The blood supply to the medulla was determined by the injection of indian ink via the vertebral arteries. Virtually the whole medulla was supplied by penetrating vessels from the ventral surface. The highest density of small arterioles and venules was found close to th... | [
-0.04655255749821663,
0.017764465883374214,
0.02085614949464798,
0.017302071675658226,
0.01673375628888607,
-0.0008668130612932146,
0.08710096776485443,
0.05283612757921219,
0.00957814883440733,
0.04130147024989128,
0.0089655052870512,
-0.08422648906707764,
-0.020360074937343597,
0.0316840... |
PMID:22746 | Effect of 4-aminopyridine on release of noradrenaline from the perfused cat spleen by nerve stimulation. | 1. 4-aminopyridine (4-AP, 1 mM) increased noradrenaline (NA) output from the perfused cat spleen at 5 Hz by about fivefold. Enhancement of NA release by 4-AP was reversible. Output of NA induced by potassium was not affected. 2. NA output was doubled at low concentrations (0.1--0.3 mM) of 4-AP, but maximal effect was o... | Effect of 4-aminopyridine on release of noradrenaline from the perfused cat spleen by nerve stimulation. 1. 4-aminopyridine (4-AP, 1 mM) increased noradrenaline (NA) output from the perfused cat spleen at 5 Hz by about fivefold. Enhancement of NA release by 4-AP was reversible. Output of NA induced by potassium was not... | [
-0.031052345409989357,
-0.00016667267482262105,
-0.0017123222351074219,
0.0587979294359684,
0.0025021780747920275,
-0.017874831333756447,
0.05278370529413223,
0.011805451475083828,
-0.027927177026867867,
-0.03848526254296303,
0.03691757842898369,
-0.026386400684714317,
-0.01399789284914732,
... |
PMID:22748 | Pyrazolodiazepines. 2. 4-Aryl-1,3-dialkyl-6,8-dihydropyrazolo[3,4-e] [1,4]diazepin-7(1H)-ones as antianxiety and anticonvulsant agents. | A series of 4-aryl-1,3-dialkyl-6,8-dihydropyrazolo[3,4-e] [1,4]diazepin-7(1H)-ones was synthesized and screened for psychotropic activity. In animals, a number of these pyrazolodiazepinones had strong CNS effects similar to diazepam. One compound, 4-(2-fluorophenyl)-6,8-dihydro-1,3,8-trimethylpyrazolo[3,4-e] [1,4]diaze... | Pyrazolodiazepines. 2. 4-Aryl-1,3-dialkyl-6,8-dihydropyrazolo[3,4-e] [1,4]diazepin-7(1H)-ones as antianxiety and anticonvulsant agents. A series of 4-aryl-1,3-dialkyl-6,8-dihydropyrazolo[3,4-e] [1,4]diazepin-7(1H)-ones was synthesized and screened for psychotropic activity. In animals, a number of these pyrazolodiazepi... | [
-0.04644234478473663,
-0.016308093443512917,
0.011799468658864498,
0.0403083935379982,
0.01629108563065529,
0.002013336168602109,
-0.025540491566061974,
0.04163648933172226,
-0.010822010226547718,
-0.042804792523384094,
-0.022805267944931984,
-0.0012782509438693523,
-0.013736757449805737,
... |
PMID:22749 | Synthetic models of deoxyribonucleic acid complexes with antimalarial compounds. 3. Forces involved in the stacking interaction between aminoquinoline and the nucleotide bases. | As an approach to the problem of the nature of the forces responsible for the stacking interactions between the aminoquinoline ring of the antimalarial chloroquine and the monomeric nucleotide bases, we have examined models in which the aromatic nucleus of the drug is linked to the nucleotide bases by a trimethylene ch... | Synthetic models of deoxyribonucleic acid complexes with antimalarial compounds. 3. Forces involved in the stacking interaction between aminoquinoline and the nucleotide bases. As an approach to the problem of the nature of the forces responsible for the stacking interactions between the aminoquinoline ring of the anti... | [
-0.12293878942728043,
0.012058423832058907,
-0.03642144799232483,
0.02789062261581421,
-0.012438748963177204,
0.012968975119292736,
0.06916844844818115,
0.031891483813524246,
-0.020106345415115356,
-0.01777682453393936,
0.010267006233334541,
0.02105879783630371,
0.02435765415430069,
0.0239... |
PMID:22750 | beta-Adrenergic blocking agents. 17. 1-Phenoxy-3-phenoxyalkylamino-2-propanols and 1-alkoxyalkylamino-3-phenoxy-2-propanols. | The synthesis is described of a series of derivatives of 1-phenoxy-3-phenoxyalkylamino-2-propanols and 1-alkoxyalkylamino-3-phenoxy-2-propranols. The compounds were investigated for their beta-adrenoceptor blocking properties and many showed a surprising degree of cardioselectivity when tested in vivo in anesthetized c... | beta-Adrenergic blocking agents. 17. 1-Phenoxy-3-phenoxyalkylamino-2-propanols and 1-alkoxyalkylamino-3-phenoxy-2-propanols. The synthesis is described of a series of derivatives of 1-phenoxy-3-phenoxyalkylamino-2-propanols and 1-alkoxyalkylamino-3-phenoxy-2-propranols. The compounds were investigated for their beta-ad... | [
-0.060189589858055115,
-0.007057041861116886,
-0.03440040722489357,
0.06582698225975037,
0.020939812064170837,
0.023411350324749947,
-0.006840360350906849,
0.033351361751556396,
-0.03324509784579277,
-0.014337033033370972,
-0.008682223036885262,
-0.015387289226055145,
-0.016936233267188072,
... |
PMID:22751 | Synthesis and beta-adrenergic blocking activity of a novel class of aromatic oxime ethers. | A new series of beta-adrenergic blocking amines containing an oximino-propanolic chain linked to an aromatic nucleus was synthesized. Most of the derivatives are characterized by beta2-selectivity. The structure-activity relationship are discussed. One of the compounds, selected for further studies, was more active on ... | Synthesis and beta-adrenergic blocking activity of a novel class of aromatic oxime ethers. A new series of beta-adrenergic blocking amines containing an oximino-propanolic chain linked to an aromatic nucleus was synthesized. Most of the derivatives are characterized by beta2-selectivity. The structure-activity relation... | [
-0.06909684091806412,
-0.014084850437939167,
-0.02305564470589161,
0.013368506915867329,
0.026091692969202995,
0.022250784561038017,
0.004497597459703684,
-0.006392667535692453,
-0.025676611810922623,
-0.05336218327283859,
-0.06807460635900497,
-0.029848141595721245,
-0.0030559152364730835,
... |
PMID:22752 | Synthesis of heteroaromatic potential beta-adrenergic antagonists by the glycidol route. | The synthesis of several 3-alkylamino-2-hydroxypropyl heteroaryl ethers (13-15, 17, and 18) is described. These compounds were prepared by the alkylamination of the corresponding glycidyl ethers (6-8, 10, and 11), which in turn were obtained from the requisite heteroaryl halides and the sodium salt of glycidol. The abo... | Synthesis of heteroaromatic potential beta-adrenergic antagonists by the glycidol route. The synthesis of several 3-alkylamino-2-hydroxypropyl heteroaryl ethers (13-15, 17, and 18) is described. These compounds were prepared by the alkylamination of the corresponding glycidyl ethers (6-8, 10, and 11), which in turn wer... | [
-0.06864071637392044,
-0.02665109373629093,
-0.03376347944140434,
-0.022772381082177162,
-0.0291893407702446,
-0.004564016591757536,
-0.05666675418615341,
0.005592722445726395,
-0.035896867513656616,
-0.018363891169428825,
-0.0336916483938694,
0.013053914532065392,
-0.017431724816560745,
0... |
PMID:22753 | (1-(3-(Phenothiazin-10-yl)propyl)-4-piperidinyl)phenylmethanones, a novel class of long-acting neuroleptic agents. | In previous studies the phenyl-4-piperidinylmethanone moiety was shown to be a neuroleptic pharmacophore. A short series of [1-[3-(phenothiazin-10-yl)propyl]-4-piperidinyl]phenylmethanones was prepared and tested for neuroleptic activity using the blockade of d-amphetamine lethality in aggregated mice and suppression o... | (1-(3-(Phenothiazin-10-yl)propyl)-4-piperidinyl)phenylmethanones, a novel class of long-acting neuroleptic agents. In previous studies the phenyl-4-piperidinylmethanone moiety was shown to be a neuroleptic pharmacophore. A short series of [1-[3-(phenothiazin-10-yl)propyl]-4-piperidinyl]phenylmethanones was prepared and... | [
-0.03392839804291725,
-0.023172063753008842,
-0.037673451006412506,
0.03826224431395531,
0.02253034897148609,
0.04574127495288849,
0.056679386645555496,
0.027863135561347008,
-0.012943500652909279,
-0.032867394387722015,
0.010788598097860813,
-0.0013762705493718386,
0.071498341858387,
0.06... |
PMID:22754 | Potential inhibitors of L-asparagine biosynthesis. 4. Substituted sulfonamide and sulfonylhydrazide analogues of L-asparagine. | Several N-substituted sulfonamides and N'-substituted sulfonylhydrazides have been prepared as sulfur analogues of L-asparagine with the potential of acting as inhibitors of L-asparagine synthetase (ASase, from Novikoff hepatoma). L-Cysteine was converted in known steps to N-carboxy-3-(sulfonylchloro)-L-alanine dibenzy... | Potential inhibitors of L-asparagine biosynthesis. 4. Substituted sulfonamide and sulfonylhydrazide analogues of L-asparagine. Several N-substituted sulfonamides and N'-substituted sulfonylhydrazides have been prepared as sulfur analogues of L-asparagine with the potential of acting as inhibitors of L-asparagine synthe... | [
-0.07686508446931839,
0.004917887505143881,
-0.04094759747385979,
0.05238594859838486,
0.013459390960633755,
0.04427209123969078,
0.03096066601574421,
0.024852033704519272,
-0.10477275401353836,
0.03452623635530472,
-0.00806581974029541,
-0.0030079481657594442,
0.013736706227064133,
0.0216... |
PMID:22755 | Selective monoamine oxidase inhibitors. 1. Compounds related to 4-aminophenethylamine. | A series of derivatives of 4-aminophenethylamine was synthesized and their effect on monoamine oxidase (MAO) activity in the brain was evaluated. Several of the new compounds were potent and selective inhibitors of the A form of MAO but were poor inhibitors of the B form. The most active compounds were the 2,6-dichloro... | Selective monoamine oxidase inhibitors. 1. Compounds related to 4-aminophenethylamine. A series of derivatives of 4-aminophenethylamine was synthesized and their effect on monoamine oxidase (MAO) activity in the brain was evaluated. Several of the new compounds were potent and selective inhibitors of the A form of MAO ... | [
-0.07059212028980255,
0.021994762122631073,
-0.07967088371515274,
0.016128888353705406,
-0.037023961544036865,
0.07993030548095703,
0.07093863934278488,
0.01523288432508707,
-0.054046258330345154,
-0.04779558256268501,
-0.0015826148446649313,
-0.010394034907221794,
0.013495109044015408,
0.... |
PMID:22756 | Adrenoceptor blocking agents. 2. 2-(alpha-Hydroxyarylmethyl)-3,3-dimethylaziridines, a new class of selective beta2-adrenoceptor antagonists. | Threo- and erythro-2-(alpha-hydroxybenzyl)-3,3-dimethylaziridines (1a and 1b) and threo-2-[alpha-hydroxy(2-naphthyl)methyl]- and 2-[alpha-hydroxy(3,4-dichlorobenzyl)]-3,3-dimethylaziridines (1d and 1c) have been prepared as conformationally restricted analogues of beta-adrenoceptor blocking agents like dichloroisoprote... | Adrenoceptor blocking agents. 2. 2-(alpha-Hydroxyarylmethyl)-3,3-dimethylaziridines, a new class of selective beta2-adrenoceptor antagonists. Threo- and erythro-2-(alpha-hydroxybenzyl)-3,3-dimethylaziridines (1a and 1b) and threo-2-[alpha-hydroxy(2-naphthyl)methyl]- and 2-[alpha-hydroxy(3,4-dichlorobenzyl)]-3,3-dimethy... | [
-0.10537682473659515,
-0.004128600005060434,
-0.05725495144724846,
0.09243945777416229,
-0.0006420035497285426,
0.010849238373339176,
0.013790074735879898,
0.03819885104894638,
-0.049390386790037155,
-0.03752167150378227,
-0.005326109007000923,
-0.015457314439117908,
-0.06569670140743256,
... |
PMID:22757 | Antidepressant agents. 9. 3,3-Diphenylcyclobutylamines, a new class of central stimulants. | 3,3-Diphenylcyclobutylamine (4), N-methyl-3,3-diphenylcyclobutylamine (6), and N,N-dimethyl-3,3-diphenyl-cyclobutylamine (7) have been prepared and tested as potential antidepressant agents. The secondary (6) and tertiary (7) amines strongly decrease the accumulation of NA and 5-HT in brain slices in vitro and in vivo.... | Antidepressant agents. 9. 3,3-Diphenylcyclobutylamines, a new class of central stimulants. 3,3-Diphenylcyclobutylamine (4), N-methyl-3,3-diphenylcyclobutylamine (6), and N,N-dimethyl-3,3-diphenyl-cyclobutylamine (7) have been prepared and tested as potential antidepressant agents. The secondary (6) and tertiary (7) ami... | [
-0.03615856170654297,
0.031176727265119553,
-0.033348146826028824,
0.0655670240521431,
-0.047923363745212555,
0.05301748216152191,
-0.00412943447008729,
0.022198550403118134,
-0.013002032414078712,
-0.059555038809776306,
0.019919734448194504,
-0.0036455958615988493,
-0.00009112032421398908,
... |
PMID:22758 | Disseminated intravascular coagulopathy during experimental pneumococcal sepsis: studies in normal and asplenic rhesus monkeys. | Disseminated intravascular coagulation (DIC) was induced in both normal and asplenic rhesus monkeys by intravenous challenge with Streptococcus pneumoniae. Our observations in the infected monkeys have led us to conclude that (1) pneumococcal capsular polysaccharide (PCP), immune complexes and complement may not have p... | Disseminated intravascular coagulopathy during experimental pneumococcal sepsis: studies in normal and asplenic rhesus monkeys. Disseminated intravascular coagulation (DIC) was induced in both normal and asplenic rhesus monkeys by intravenous challenge with Streptococcus pneumoniae. Our observations in the infected mon... | [
-0.09145845472812653,
0.035542119294404984,
-0.04588194191455841,
-0.035961754620075226,
0.07204246520996094,
0.005080364644527435,
0.06113031879067421,
0.09916005283594131,
-0.025722093880176544,
-0.023789215832948685,
0.041115131229162216,
-0.11393724381923676,
-0.045069415122270584,
-0.... |
PMID:22764 | A sexual-enhancement workshop: beyond group systematic desensitization for women's sexual anxiety. | This study investigated whether six women who previously had received 15 sessions of group systematic desensitization (SD) for their sexual anxiety would report additional treatment gains from participation in a sexual-enhancement workshop with their partners. After group SD six couples participated in six, 1 1/2 hour ... | A sexual-enhancement workshop: beyond group systematic desensitization for women's sexual anxiety. This study investigated whether six women who previously had received 15 sessions of group systematic desensitization (SD) for their sexual anxiety would report additional treatment gains from participation in a sexual-en... | [
0.050052545964717865,
0.02881249412894249,
0.020608248189091682,
-0.013972283340990543,
0.039515089243650436,
0.021537819877266884,
0.01076944638043642,
-0.002763990545645356,
0.00757742440328002,
-0.07790999859571457,
0.056606099009513855,
-0.034323837608098984,
0.04877113178372383,
0.001... |
PMID:22766 | Transcriptase activity associated with rabies virion. | Rabies virion-associated transcriptase activity was investigated in vitro and compared with that of the New Jersey serotype of vesicular stomatitis virus. The concentration of detergent that affected [3H]GMP incoporation into acid-insoluble material was significantly different for both viruses. Vesicular stomatitis vir... | Transcriptase activity associated with rabies virion. Rabies virion-associated transcriptase activity was investigated in vitro and compared with that of the New Jersey serotype of vesicular stomatitis virus. The concentration of detergent that affected [3H]GMP incoporation into acid-insoluble material was significantl... | [
-0.018579989671707153,
-0.013905806466937065,
-0.03757113590836525,
-0.04579908400774002,
0.03987688571214676,
-0.02509678713977337,
0.006389734800904989,
0.0519254170358181,
-0.01414251048117876,
0.011648673564195633,
0.0038855932652950287,
-0.03781934455037117,
0.009647051803767681,
0.03... |
PMID:22767 | The increasing incidence of Ampicillin-resistant Haemophilus influenzae. A cause of otitis media. | Middle ear exudate was obtained by myringotomy or aspiration from 625 suburban children, aged 1 month to 12 years, who had acute otitis media; bacterial pathogens were isolated from 71%. Haemophilus species were isolated from 212 (29%), and Streptococcus pneumoniae from 205 (28%). From 1975 to August 1977, the number o... | The increasing incidence of Ampicillin-resistant Haemophilus influenzae. A cause of otitis media. Middle ear exudate was obtained by myringotomy or aspiration from 625 suburban children, aged 1 month to 12 years, who had acute otitis media; bacterial pathogens were isolated from 71%. Haemophilus species were isolated f... | [
-0.044540125876665115,
-0.023120040073990822,
0.0015592256095260382,
-0.016478929668664932,
0.05081268399953842,
0.018318425863981247,
0.0037494490388780832,
0.09755218029022217,
-0.0866459310054779,
0.03715648502111435,
0.014539806172251701,
-0.04724515229463577,
0.016455186530947685,
-0.... |
PMID:22768 | Inhibition by cyanide of drug oxidations in rat liver microsomes. | Cyanide inhibited microsomal activities of aniline hydroxylation and aminopyrine, ethylmorphine and codeine demethylations and produced a modified type II difference spectrum of cytochrome P-450 to give two spectral dissociation constants, 0.21mM and 1.05 mM. The binding of cyanide to cytochrome P-450 resulted in innhi... | Inhibition by cyanide of drug oxidations in rat liver microsomes. Cyanide inhibited microsomal activities of aniline hydroxylation and aminopyrine, ethylmorphine and codeine demethylations and produced a modified type II difference spectrum of cytochrome P-450 to give two spectral dissociation constants, 0.21mM and 1.0... | [
-0.08197931945323944,
0.015159334987401962,
-0.02480858564376831,
0.04017462208867073,
0.014224302023649216,
-0.013445703312754631,
0.08620679378509521,
0.009906782768666744,
-0.05169469118118286,
0.010271582752466202,
-0.016248563304543495,
0.0277412049472332,
0.03868897259235382,
0.03658... |
PMID:22769 | Impaired maturation of pre-synaptic cholinergic nerve terminals in the superior cervical ganglia after administration of guanethidine and dexamethasone. | The role of post-synaptic cells in the development of pre-synaptic cholinergic nerve terminals has been investigated in immature rat superior cervical ganglia (SCG) and adrenals employing chemical agents which prevent the normal maturation of post-synaptic cells. A marked atrophy of ganglion adrenergic neurons after gu... | Impaired maturation of pre-synaptic cholinergic nerve terminals in the superior cervical ganglia after administration of guanethidine and dexamethasone. The role of post-synaptic cells in the development of pre-synaptic cholinergic nerve terminals has been investigated in immature rat superior cervical ganglia (SCG) an... | [
-0.010438412427902222,
-0.04015782102942467,
-0.009916460141539574,
0.01752110943198204,
-0.06388726830482483,
0.004747807048261166,
0.03303263336420059,
-0.02396118827164173,
-0.008321618661284447,
-0.07359974831342697,
0.017410313710570335,
-0.053873222321271896,
0.036726079881191254,
0.... |
PMID:22771 | Enhancement of NADPH-dependent lipid peroxidation activity by ethylene-diamineteraacetic acid (EDTA) in the presence of ferrous ion in rabbit liver microsomes. | The addition of EDTA to the incubation mixture containing rabbit liver microsomes and ferrous ion resulted in 2-fold increase of lipid peroxidation activity. Such an enhancement was not observed in rat liver microsomes. The maximum lipid peroxidation activity seen in rabbit microsomes in the presence of EDTA and ferrou... | Enhancement of NADPH-dependent lipid peroxidation activity by ethylene-diamineteraacetic acid (EDTA) in the presence of ferrous ion in rabbit liver microsomes. The addition of EDTA to the incubation mixture containing rabbit liver microsomes and ferrous ion resulted in 2-fold increase of lipid peroxidation activity. Su... | [
-0.01244254782795906,
-0.017617980018258095,
0.011618167161941528,
0.03768230229616165,
0.04781774803996086,
-0.006508421618491411,
0.010981305502355099,
0.07885001599788666,
-0.07954338937997818,
-0.029487669467926025,
0.022403975948691368,
-0.056682877242565155,
-0.024729961529374123,
-0... |
PMID:22774 | [Psychotropic drugs--real progress or danger? (author's transl)]. | Three types of modern psychotropic drugs strongly influenced the practice of psychiatric therapy during the past 25 years: Minor tranquilizers, Antidepressants, and Neuroleptics. 1. From the clinical point of view the effects of tranquilizers are more unspecific as compared to those of neuroleptic and antidepressant dr... | [Psychotropic drugs--real progress or danger? (author's transl)]. Three types of modern psychotropic drugs strongly influenced the practice of psychiatric therapy during the past 25 years: Minor tranquilizers, Antidepressants, and Neuroleptics. 1. From the clinical point of view the effects of tranquilizers are more un... | [
-0.00975034199655056,
0.0415646992623806,
0.0525432750582695,
0.011540809646248817,
0.007163244299590588,
0.028758719563484192,
0.059313274919986725,
0.006741318851709366,
-0.012027880176901817,
-0.05163518339395523,
0.011353198438882828,
0.01853085868060589,
-0.0010181334801018238,
0.0279... |
PMID:22778 | Effects of sodium ions on the electrical and pH gradients across the membrane of Streptococcus lactis cells. | Energized cells of Streptococcus lactis conserve and transduce energy at the plasma membrane in the form of an electrochemical gradient of hydrogen ions (deltap). An increase in energy-consuming processes, such as cation transport, would be expected to result in a change in the steady state deltap. We determined the el... | Effects of sodium ions on the electrical and pH gradients across the membrane of Streptococcus lactis cells. Energized cells of Streptococcus lactis conserve and transduce energy at the plasma membrane in the form of an electrochemical gradient of hydrogen ions (deltap). An increase in energy-consuming processes, such ... | [
-0.0897415280342102,
-0.002130156382918358,
-0.007597079500555992,
0.04811030253767967,
-0.0029586900491267443,
-0.010974234901368618,
0.03391534090042114,
0.02384144254028797,
0.010358487255871296,
0.006341479253023863,
0.01887303777039051,
-0.07714201509952545,
0.010117979720234871,
0.04... |
PMID:22779 | Energetics of galactose, proline, and glutamine transport in a cytochrome-deficient mutant of Salmonella typhimurium. | The effect of inhibitors and uncouplers on the osmotic shock-sensitive transport systems for glutamine and galactose (by the beta-methyl galactoside permease) was compared to their effect on the osmotic shock-resistant proline and galactose permease systems in cytochrome-deficient cells of Salmonella typhimurium SASY28... | Energetics of galactose, proline, and glutamine transport in a cytochrome-deficient mutant of Salmonella typhimurium. The effect of inhibitors and uncouplers on the osmotic shock-sensitive transport systems for glutamine and galactose (by the beta-methyl galactoside permease) was compared to their effect on the osmotic... | [
-0.1047263815999031,
-0.056763917207717896,
-0.037774134427309036,
0.013166604563593864,
0.03778180852532387,
-0.05813993513584137,
0.0648282840847969,
0.011408205144107342,
-0.047568246722221375,
-0.03988039493560791,
0.06793040037155151,
-0.06957497447729111,
-0.007640882860869169,
0.002... |
PMID:22775 | [Model of motion sickness in dogs for assessing the effectiveness of pharmacological substances]. | The paper describes a model of motion sickness for dogs. The method is based on the simultaneous use of vertical and rotatory movement of the device with a continuously varying angular velocity of rotation to generate Coriolis acceleration. The exposure increases significantly the number of sick animals to be used in t... | [Model of motion sickness in dogs for assessing the effectiveness of pharmacological substances]. The paper describes a model of motion sickness for dogs. The method is based on the simultaneous use of vertical and rotatory movement of the device with a continuously varying angular velocity of rotation to generate Cori... | [
-0.07948291301727295,
-0.003742951201274991,
0.04883227124810219,
0.05042453855276108,
0.01399717666208744,
0.04015978053212166,
0.055678840726614,
0.057631492614746094,
-0.03821801021695137,
0.008102064952254295,
-0.024691086262464523,
-0.05510449782013893,
0.014561152085661888,
0.0128815... |
PMID:22776 | [Hygienic evaluation of the water reclaimed from various moisture-containing wastes]. | The paper reviews 5 experiments on 25 healthy male test subjects, aged 20-36. For drinking and cooking they used water reclaimed from various water-containing wastes (atmospheric condensate, urine, fluids used in engineering processes and biological wastes) by the oxidation-catalytic and sorption techniques. The result... | [Hygienic evaluation of the water reclaimed from various moisture-containing wastes]. The paper reviews 5 experiments on 25 healthy male test subjects, aged 20-36. For drinking and cooking they used water reclaimed from various water-containing wastes (atmospheric condensate, urine, fluids used in engineering processes... | [
-0.011384022422134876,
0.057635195553302765,
0.035213783383369446,
-0.004205431789159775,
0.06907906383275986,
-0.05453278124332428,
0.05239618569612503,
0.006607760675251484,
-0.03658275678753853,
-0.024372108280658722,
-0.03732573986053467,
-0.09358051419258118,
0.025595510378479958,
-0.... |
PMID:22780 | Pilot open-label study of triazolam in the treatment of insomnia following alcohol withdrawal. | Insomnia and anxiety decreased in 12 outpatients taking triazolam following alcohol withdrawal. | Pilot open-label study of triazolam in the treatment of insomnia following alcohol withdrawal. Insomnia and anxiety decreased in 12 outpatients taking triazolam following alcohol withdrawal. | [
0.05209698900580406,
-0.0029510657768696547,
-0.02148096077144146,
0.026546793058514595,
0.03428724408149719,
-0.009590926580131054,
0.06520933657884598,
0.06982175260782242,
-0.016180239617824554,
-0.0428345650434494,
0.015680288895964622,
0.0001977344072656706,
-0.05625312775373459,
-0.0... |
PMID:22777 | [Variants of the control over a gas-exchange closed ecosystem with a periodically operating autotrophic component]. | The paper discusses the problem of how to control a gas exchange closed ecosystem that consists of autotrophic and heterotrophic components and operates periodically in the light or in the dark. The purpose of the control is to maintain the steady state of an ecosystem with a man-oriented atmosphere. This problem of co... | [Variants of the control over a gas-exchange closed ecosystem with a periodically operating autotrophic component]. The paper discusses the problem of how to control a gas exchange closed ecosystem that consists of autotrophic and heterotrophic components and operates periodically in the light or in the dark. The purpo... | [
-0.016607649624347687,
0.007171531207859516,
0.032771047204732895,
0.03821174055337906,
0.037670623511075974,
-0.0002019960229517892,
0.005873678717762232,
0.002527376636862755,
-0.057854004204273224,
0.01089849416166544,
-0.002853936981409788,
-0.031233124434947968,
-0.001115514081902802,
... |
PMID:22783 | [Diagnosis and treatment of postoperative infections following hip injuries]. | The authors studied the diagnosis and treatment of posttraumatic infections of the hip joint, based on their own material. In case of latent infection the increased sedimentation rate and taking of comparative X-ray films are held important, that shows a narrowing and disappearance of the sclerosed edge of the acetabul... | [Diagnosis and treatment of postoperative infections following hip injuries]. The authors studied the diagnosis and treatment of posttraumatic infections of the hip joint, based on their own material. In case of latent infection the increased sedimentation rate and taking of comparative X-ray films are held important, ... | [
0.023493725806474686,
0.04868057370185852,
0.01769491285085678,
-0.024798426777124405,
0.05304213613271713,
0.025264054536819458,
0.03819681704044342,
0.1130775585770607,
-0.0021284555550664663,
-0.04189642518758774,
0.0030054666567593813,
-0.024743571877479553,
-0.012157987803220749,
0.03... |
PMID:22785 | [Treatment of childhood humeral fractures by wire fixation]. | Out of 526 upper limb fractures treated in the Pediatric Surgery Department of the Péterfy Sándor Hospital between 1970-1975, 63 patients were operated on. (11.9%). Fractures in childhood are generally treated by closed methods because healing of the growing bone is favourable. If it is reasonable, fractures of the for... | [Treatment of childhood humeral fractures by wire fixation]. Out of 526 upper limb fractures treated in the Pediatric Surgery Department of the Péterfy Sándor Hospital between 1970-1975, 63 patients were operated on. (11.9%). Fractures in childhood are generally treated by closed methods because healing of the growing ... | [
0.02012181095778942,
-0.029355492442846298,
0.03443129360675812,
-0.024800175800919533,
0.0033318225760012865,
-0.013506269082427025,
-0.02392919547855854,
0.015307853929698467,
-0.08386038988828659,
-0.00387110048905015,
0.040581800043582916,
-0.0462370403110981,
0.014231598936021328,
0.0... |
PMID:22787 | [The role of orthopedic surgery in the treatment of spastic patients]. | The authors performed 958 operations on spastic patients. Based on this clinical material, they introduce the possibilities and principles of operative treatment. Position of joints in the lower limb, their synergism and compensatory changes in a closed kinetic chain are analysed in the article. These factors must be a... | [The role of orthopedic surgery in the treatment of spastic patients]. The authors performed 958 operations on spastic patients. Based on this clinical material, they introduce the possibilities and principles of operative treatment. Position of joints in the lower limb, their synergism and compensatory changes in a cl... | [
0.034787677228450775,
-0.023424359038472176,
0.06463725864887238,
-0.02157764695584774,
-0.05331575870513916,
0.05582358315587044,
0.023303208872675896,
0.08310152590274811,
0.007012396119534969,
-0.017547065392136574,
0.003235332202166319,
0.008363169617950916,
0.0013065675739198923,
0.05... |
PMID:22788 | [Possibilities of treatment of open fractures of the tibia]. | Results of healing in 477 cases of open leg fractures treated in the Central Institut of Traumatology in Budapest are analysed in the article. 47,2% of cases were treated by closed methods. The authors are convinced that careful conservative management leads to good results, if the type of the fracture is suitable. Con... | [Possibilities of treatment of open fractures of the tibia]. Results of healing in 477 cases of open leg fractures treated in the Central Institut of Traumatology in Budapest are analysed in the article. 47,2% of cases were treated by closed methods. The authors are convinced that careful conservative management leads ... | [
0.002868928946554661,
-0.03766715154051781,
0.03724062815308571,
-0.011622060090303421,
0.030750565230846405,
0.011844093911349773,
0.013625037856400013,
0.08448291569948196,
-0.03367553651332855,
0.011548281647264957,
-0.004005924332886934,
-0.0684637501835823,
-0.04357735812664032,
0.134... |
PMID:22789 | [Stable osteosynthesis on the hand]. | The authors write on the usefulness of the A.S.I.F. Small Fragment Instrumentary, its possible ways of application in the treatment of fractures of bones of the hand. The operative techniques is introduced, indication and contraindications based on the clinical material of the authors are discussed in the article. Limi... | [Stable osteosynthesis on the hand]. The authors write on the usefulness of the A.S.I.F. Small Fragment Instrumentary, its possible ways of application in the treatment of fractures of bones of the hand. The operative techniques is introduced, indication and contraindications based on the clinical material of the autho... | [
-0.03429582715034485,
0.004456166177988052,
-0.022065334022045135,
-0.056268107146024704,
-0.01791362278163433,
-0.0046620843932032585,
0.028136849403381348,
0.03245498239994049,
-0.07020339369773865,
-0.026034722104668617,
-0.008776982314884663,
-0.03499018773436546,
0.031187206506729126,
... |
PMID:22790 | [Syringomyelia with severe osteo-articular changes]. | Attention was drawn to a patient after admission to the Central Institute of Oncology, and syringomyelia was diagnosed on the basis of X-ray films taken by the author. The deformations were symmetrical and they were localized in the area of innervation of the C VI, VII, D I segment. The radiological diagnosis was prove... | [Syringomyelia with severe osteo-articular changes]. Attention was drawn to a patient after admission to the Central Institute of Oncology, and syringomyelia was diagnosed on the basis of X-ray films taken by the author. The deformations were symmetrical and they were localized in the area of innervation of the C VI, V... | [
0.012636772356927395,
-0.01553000882267952,
0.038522299379110336,
-0.056352563202381134,
0.016961142420768738,
0.06713450700044632,
0.02093609608709812,
0.06010346859693527,
-0.05391284078359604,
0.006857868283987045,
0.029260316863656044,
-0.01940780319273472,
-0.023089664056897163,
0.033... |
PMID:22792 | Evidence for inhibition of dopamine-beta-hydroxylase in vivo after sub-acute pyrazole treatment in rats. | Pyrazole, a widely used inhibitor of alcohol dehydrogenase, has been shown to cause a decrease of brain and heart noradrenaline (NA). An attempt to explain the mechanism of this effect is now described. L-DOPA (50-200 mg/kg, s.c.) was unable to restore brain or heart noradrenaline levels in pyrazole pre-treated rats. A... | Evidence for inhibition of dopamine-beta-hydroxylase in vivo after sub-acute pyrazole treatment in rats. Pyrazole, a widely used inhibitor of alcohol dehydrogenase, has been shown to cause a decrease of brain and heart noradrenaline (NA). An attempt to explain the mechanism of this effect is now described. L-DOPA (50-2... | [
-0.025939607992768288,
0.020251136273145676,
-0.032763171941041946,
0.045883823186159134,
-0.03905728831887245,
0.02292114868760109,
0.009018555283546448,
0.020013485103845596,
-0.03445843234658241,
-0.06659895181655884,
0.027114620432257652,
0.007002700120210648,
0.00771475350484252,
0.08... |
PMID:22793 | Physicians, physicians' assistants, and the social characteristics of patients in southern Appalachia. | A focus on health care delivery systems and the emergence of New Health Practitioners, particularly Physicians' Assistants (PAs), represents one of the more significant nonbiomedical developments in American medicine since World War II. Much discussion about PAs revolves around the kinds of illnesses they are qualified... | Physicians, physicians' assistants, and the social characteristics of patients in southern Appalachia. A focus on health care delivery systems and the emergence of New Health Practitioners, particularly Physicians' Assistants (PAs), represents one of the more significant nonbiomedical developments in American medicine ... | [
-0.012593401595950127,
0.04302644729614258,
-0.03481466323137283,
0.011401597410440445,
0.012312049977481365,
-0.037855859845876694,
0.08168210089206696,
0.03911883756518364,
-0.06317109614610672,
-0.023107534274458885,
0.04720853641629219,
0.06094278022646904,
-0.0016594838816672564,
-0.0... |
PMID:22794 | The distribution of physician extenders. | As part of the Medicare Physician Extender Reimbursement Study, a mail survey was conducted of 5,572 physician extenders (PEs) to identify potential study participants. Analysis of survey results indicates that PEs are distributed disproportionately more often than physicians to primary care practices and to rural low ... | The distribution of physician extenders. As part of the Medicare Physician Extender Reimbursement Study, a mail survey was conducted of 5,572 physician extenders (PEs) to identify potential study participants. Analysis of survey results indicates that PEs are distributed disproportionately more often than physicians to... | [
-0.02909383922815323,
0.004550458863377571,
-0.01628435030579567,
-0.014898701570928097,
0.007913165725767612,
0.006447223946452141,
0.002847058232873678,
0.007323726080358028,
0.028771495446562767,
0.023304438218474388,
0.02516678348183632,
0.02246086485683918,
-0.07223664969205856,
-0.02... |
PMID:22795 | Physician assistants: an overview of an emerging health profession. | This article describes the background characteristics, work environments, and job characteristics of the physician assistant profession as they existed in late 1974 and early 1975. Of the 939 physician assistants participating in this study, three-fourths were working in primary care specialties and half were located i... | Physician assistants: an overview of an emerging health profession. This article describes the background characteristics, work environments, and job characteristics of the physician assistant profession as they existed in late 1974 and early 1975. Of the 939 physician assistants participating in this study, three-four... | [
-0.03538936376571655,
-0.003187044057995081,
0.00045129115460440516,
-0.028527995571494102,
0.004621424712240696,
0.012757331132888794,
0.04031302034854889,
0.006298802327364683,
-0.06754706054925919,
0.009242565371096134,
0.05977362394332886,
0.010883377864956856,
-0.013945874758064747,
-... |
PMID:22796 | The effectiveness and cost of acute respiratory illness medical care provided by physicians and algorithm-assisted physicians' assistants. | The medical management of patients with acute respiratory illnesses was analyzed at two different clinics during a 14- to 21-month period. Patients received care from either physicians or physician-supervised physician's assistants (PA). The PAs used respiratory illness clinical algorithms to guide their choice of diag... | The effectiveness and cost of acute respiratory illness medical care provided by physicians and algorithm-assisted physicians' assistants. The medical management of patients with acute respiratory illnesses was analyzed at two different clinics during a 14- to 21-month period. Patients received care from either physici... | [
-0.049351491034030914,
0.04074041545391083,
0.021777965128421783,
-0.02808132953941822,
0.03952861204743385,
-0.023904161527752876,
0.060867249965667725,
0.05347416549921036,
-0.02913244627416134,
0.0006914390251040459,
0.00014016503700986505,
0.03493114560842514,
-0.008312921971082687,
0.... |
PMID:22797 | [Changes of serum and urinary uric-acid levels after portacaval anastomosis in the rat]. | Significantly higher levels of uric acid in serum and urine together with increased urine volume and pH were observed in rats after portacaval end-to-side anastomosis in comparison to sham-operated and non-operated pair-fed controls. An increased supply of endogenous uric acid by reduced transformation of uric acid to ... | [Changes of serum and urinary uric-acid levels after portacaval anastomosis in the rat]. Significantly higher levels of uric acid in serum and urine together with increased urine volume and pH were observed in rats after portacaval end-to-side anastomosis in comparison to sham-operated and non-operated pair-fed control... | [
-0.04728148877620697,
0.00287566683255136,
0.018683891743421555,
0.029833147302269936,
-0.0011392513988539577,
0.026457438245415688,
0.027852138504385948,
0.06716427206993103,
-0.026958150789141655,
-0.007387451361864805,
0.04836871474981308,
-0.10728863626718521,
0.0037913788110017776,
0.... |
PMID:22798 | The dietary regulation of stearyl coenzyme A desaturase activity and membrane fluidity in the rat aorta. | Numerous studies have demonstrated that alterations in membrane composition or fluidity are often associated with alterations in the properties of membrane-bound enzymes. In order to obtain membranes of varying fluidity, rats were fed diets that were either fat-free or supplemented with 15% safflower oil, and two prope... | The dietary regulation of stearyl coenzyme A desaturase activity and membrane fluidity in the rat aorta. Numerous studies have demonstrated that alterations in membrane composition or fluidity are often associated with alterations in the properties of membrane-bound enzymes. In order to obtain membranes of varying flui... | [
-0.010197406634688377,
-0.02916448563337326,
-0.021846164017915726,
0.020369695499539375,
-0.04320960119366646,
-0.03292049840092659,
-0.000288038223516196,
0.0488954558968544,
-0.009298034943640232,
-0.05536795035004616,
0.008539089933037758,
-0.10244414955377579,
-0.016673006117343903,
0... |
PMID:22803 | Biochemical properties of a penicillinase from Escherichia coli carrying Rms 298. | We obtained two R plasmids, i.e., Rms195 and Rms298, from a clinical isolate, E. coli GN5503. Penicillin beta-lactamase (PCase) was extracted from ML1410 Rms195+ and Rms298+, and was purified by chromatography. Rms195 PCase was identical to the type I PCase mediated by R-TEM, RI and Rms212. The isoelectric point of Rms... | Biochemical properties of a penicillinase from Escherichia coli carrying Rms 298. We obtained two R plasmids, i.e., Rms195 and Rms298, from a clinical isolate, E. coli GN5503. Penicillin beta-lactamase (PCase) was extracted from ML1410 Rms195+ and Rms298+, and was purified by chromatography. Rms195 PCase was identical ... | [
-0.05463080480694771,
-0.04356997832655907,
-0.03959623724222183,
-0.020024031400680542,
0.057422976940870285,
0.015451038256287575,
-0.020963730290532112,
0.04182879626750946,
-0.021368062123656273,
0.0017375311581417918,
0.006245724856853485,
-0.053298600018024445,
0.0268258024007082,
0.... |
PMID:22810 | [Neurological complications following whooping-cough vaccination (author's transl)]. | The clinical symptoms, frequency, etiology, pathogenesis and differential diagnosis of neurological complications following immunisation against pertussis are being discussed. Guide lines are presented for the evaluation of the causal connection between the observed complications and the vaccination. | [Neurological complications following whooping-cough vaccination (author's transl)]. The clinical symptoms, frequency, etiology, pathogenesis and differential diagnosis of neurological complications following immunisation against pertussis are being discussed. Guide lines are presented for the evaluation of the causal ... | [
-0.0032710256054997444,
0.007965725846588612,
-0.012313704006373882,
-0.03677001968026161,
0.010904970578849316,
-0.025403570383787155,
0.08628058433532715,
0.057949844747781754,
-0.03766408562660217,
-0.016302308067679405,
-0.05823158845305443,
-0.05416708439588547,
0.0021453946828842163,
... |
PMID:22812 | Mutagenic and recombinogenic action of pesticides in Aspergillus nidulans. | Thirteen pesticides, aminotriazole, benomyl, captafol, captan, dalapon-Na, dichlorvos, dinobuton, dodine, ioxynil, mecoprop, neburon, picloram and tordon were tested for ability to induce (1) point mutations to 8-azaguanine resistance, (2) mitotic crossing-over, and (3) mitotic non-disjunction and haploidization in Asp... | Mutagenic and recombinogenic action of pesticides in Aspergillus nidulans. Thirteen pesticides, aminotriazole, benomyl, captafol, captan, dalapon-Na, dichlorvos, dinobuton, dodine, ioxynil, mecoprop, neburon, picloram and tordon were tested for ability to induce (1) point mutations to 8-azaguanine resistance, (2) mitot... | [
-0.05819254741072655,
0.0037043693009763956,
-0.013279571197926998,
-0.0011090233456343412,
0.016937294974923134,
0.0022030186373740435,
0.0275946706533432,
0.017668552696704865,
-0.10475189983844757,
-0.011071478016674519,
0.00916292518377304,
-0.08406974375247955,
0.010461254045367241,
0... |
PMID:22823 | Differentiation of cardiac chronotropic and inotropic effects of beta-adrenoceptor agonists. | The relative inotropic and chronotropic activity of beta-adrenoceptor agonists was studied in the noradrenaline-depleted, anaesthetized cat. Terbutaline, a selective beta2-adrenoceptor agonist, gave at a certain dose a more pronounced chronotropic than inotropic response, while a new beta1-selective adrenoceptor agonis... | Differentiation of cardiac chronotropic and inotropic effects of beta-adrenoceptor agonists. The relative inotropic and chronotropic activity of beta-adrenoceptor agonists was studied in the noradrenaline-depleted, anaesthetized cat. Terbutaline, a selective beta2-adrenoceptor agonist, gave at a certain dose a more pro... | [
-0.027480904012918472,
-0.017894838005304337,
-0.01292156521230936,
0.04596976563334465,
-0.018682096153497696,
0.014713355340063572,
0.006375735625624657,
0.004611928015947342,
0.00951992254704237,
-0.06497892737388611,
-0.039859838783741,
-0.02587689645588398,
-0.03156367689371109,
0.047... |
PMID:22824 | Regulation of nerve growth factor content in C6 glioma cells by beta-adrenergic receptor stimulation. | The C6 glioma cell line contains nerve growth factor (NGF) which can be released into the medium. Treatment of the cells with beta-adrenoceptor agonists resulted in increased content of NGF in both the cells and the medium within a few hours, whereas alpha-adrenoceptor agonists were ineffective. The response was blocke... | Regulation of nerve growth factor content in C6 glioma cells by beta-adrenergic receptor stimulation. The C6 glioma cell line contains nerve growth factor (NGF) which can be released into the medium. Treatment of the cells with beta-adrenoceptor agonists resulted in increased content of NGF in both the cells and the me... | [
-0.019616475328803062,
-0.02503468468785286,
-0.004936973564326763,
-0.042040735483169556,
0.01361787784844637,
0.03822037950158119,
0.04520130529999733,
-0.012354960665106773,
-0.07811224460601807,
-0.04004098102450371,
0.01486074086278677,
-0.01752602867782116,
-0.028283588588237762,
0.0... |
PMID:22825 | Effects of medium pH on p-aminohippurate transport in rat kidney fragments. | Addition of many oxidizable substrates to medium often enhances p-aminohippurate (PAH) transport by incubating renal tissue. Since the oxidation of various substrates by rat kidney tissue may change medium pH and this pH change has not been considered by many in conclusions, we followed the effects of medium pH on the ... | Effects of medium pH on p-aminohippurate transport in rat kidney fragments. Addition of many oxidizable substrates to medium often enhances p-aminohippurate (PAH) transport by incubating renal tissue. Since the oxidation of various substrates by rat kidney tissue may change medium pH and this pH change has not been con... | [
-0.01262742094695568,
-0.05362328514456749,
0.020748160779476166,
0.03002472221851349,
0.020206386223435402,
-0.015767086297273636,
0.037190601229667664,
0.012751038186252117,
-0.0547434501349926,
-0.014713294804096222,
0.05540698394179344,
-0.06964275985956192,
0.030333993956446648,
0.027... |
PMID:22826 | Further evidence on the role of the hypothalamic afferents on the estrogen-induced prolactin release. | Serum prolactin (Prl) concentrations in ovariectomized rats were low without significant differences between morning and afternoon values. These levels were not affected by either frontal or caudal hypothalamic deafferentation. However, they increased after lesioning the hypothalamic median eminence (ME). Three days af... | Further evidence on the role of the hypothalamic afferents on the estrogen-induced prolactin release. Serum prolactin (Prl) concentrations in ovariectomized rats were low without significant differences between morning and afternoon values. These levels were not affected by either frontal or caudal hypothalamic deaffer... | [
0.016788899898529053,
-0.010658133774995804,
-0.00782044604420662,
0.0034597553312778473,
0.02049192599952221,
0.0077517274767160416,
0.018789244815707207,
-0.0012584239011630416,
0.011353927664458752,
-0.04643832519650459,
-0.03959934040904045,
-0.047041554003953934,
0.018403662368655205,
... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.