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PMID:28390 | Isolation and partial characterization of trehalase from Ascaris muscle. | The tissues of female Ascaris suum were assayed for alpha,apha'-glucoside 1-D-glucohydrolase (trehalase) activity. A soluble from of the enzyme was isolated from muscle tissue and purified approximately 37-fold. The enzyme was specific for trehalose as substrate. The pH optimum for enzymatic activity was found to be 6.... | Isolation and partial characterization of trehalase from Ascaris muscle. The tissues of female Ascaris suum were assayed for alpha,apha'-glucoside 1-D-glucohydrolase (trehalase) activity. A soluble from of the enzyme was isolated from muscle tissue and purified approximately 37-fold. The enzyme was specific for trehalo... | [
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PMID:28391 | The interaction of preservatives with polyhydroxyethylmethacrylate (polyHEMA). | The interaction of the four most commonly used preservatives in contact lens solutions (chlorbutol, thiomersal, chlorhexidine gluconate and benzalkonium chloride) with polyhydroxyethylmethacrylate (polyHEMA), has been examined. Benzalkonium chloride and chlorhexidine gluconate show typical high affinity type isotherms.... | The interaction of preservatives with polyhydroxyethylmethacrylate (polyHEMA). The interaction of the four most commonly used preservatives in contact lens solutions (chlorbutol, thiomersal, chlorhexidine gluconate and benzalkonium chloride) with polyhydroxyethylmethacrylate (polyHEMA), has been examined. Benzalkonium ... | [
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PMID:28392 | Theory of the mean absorption time, an adjunct to conventional bioavailability studies. | The theory is outlined of a procedure for characterizing the time-course of drug absorption by determining the mean absorption time. The procedure requires data of the type normally collected in bioavailability studies. | Theory of the mean absorption time, an adjunct to conventional bioavailability studies. The theory is outlined of a procedure for characterizing the time-course of drug absorption by determining the mean absorption time. The procedure requires data of the type normally collected in bioavailability studies. | [
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PMID:28393 | Bioavailability of griseofulvin from a novel capsule formulation. | The in vivo availability of griseofulvin from a novel formulation has been compared with the micronized powder. The formulation technique involves the conversion of the hydrophobic surface of the drug to a hydrophilic one by treatment with a film forming polymer. This enhances the wettability of the power, and increase... | Bioavailability of griseofulvin from a novel capsule formulation. The in vivo availability of griseofulvin from a novel formulation has been compared with the micronized powder. The formulation technique involves the conversion of the hydrophobic surface of the drug to a hydrophilic one by treatment with a film forming... | [
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PMID:28394 | The relation between molecular connectivity and gas chromatographic retention data. | The recently developed topological index, molecular connectivity (chi), has been correlated using multiple regression analysis with gas chromatographic retention time (Rt) for various series of compounds. For saturated and unsaturated aliphatic hydrocarbons, and aliphatic aldehydes, good correlation with log Rt was ach... | The relation between molecular connectivity and gas chromatographic retention data. The recently developed topological index, molecular connectivity (chi), has been correlated using multiple regression analysis with gas chromatographic retention time (Rt) for various series of compounds. For saturated and unsaturated a... | [
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PMID:28395 | The percutaneous absorption of phenolic compounds: the mechanism of diffusion across the stratum corneum. | The effect of temperature on the permeation of phenolic compounds from aqueous solution through excised human skin has been examined. From a thermodynamic analysis of the data, a mechanism is postulated by which these solutes penetrate through human skin. For the more polar solutes it is suggested that the main resista... | The percutaneous absorption of phenolic compounds: the mechanism of diffusion across the stratum corneum. The effect of temperature on the permeation of phenolic compounds from aqueous solution through excised human skin has been examined. From a thermodynamic analysis of the data, a mechanism is postulated by which th... | [
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PMID:28396 | The character of the antagonism by polyphloretin phosphate of contractions to prostaglandins E1 and F 2alpha in guinea-pig ileum. | Polyphloretin phosphate (PPP) produced a dose-dependent decrease in the tone and reduction of the spontaneous phasic contactions of the longitudinal muscle of guinea-pig isolated ileum. PPP (100 microgram ml-1) after a 2 min contact with the ileum decreased the contractile effects of PGE1 0.1 micron by 40.6 +/- 7.4%, o... | The character of the antagonism by polyphloretin phosphate of contractions to prostaglandins E1 and F 2alpha in guinea-pig ileum. Polyphloretin phosphate (PPP) produced a dose-dependent decrease in the tone and reduction of the spontaneous phasic contactions of the longitudinal muscle of guinea-pig isolated ileum. PPP ... | [
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PMID:28397 | Direct effect of a nomifensine derivative on dopamine receptors. | A study was made of the effects of nomifensine, 4'-hydroxynomifensine and 3',4'-dihydroxynomifensine on dopamine receptors in rat striatum and nucleus accumbens, using the dopamine-sensitive adenylate cyclase assay. Nomifensine and its 4'-hydroxy metabolite were both inactive as dopaminergic agonists. 3',4'-dihydroxyno... | Direct effect of a nomifensine derivative on dopamine receptors. A study was made of the effects of nomifensine, 4'-hydroxynomifensine and 3',4'-dihydroxynomifensine on dopamine receptors in rat striatum and nucleus accumbens, using the dopamine-sensitive adenylate cyclase assay. Nomifensine and its 4'-hydroxy metaboli... | [
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PMID:28399 | The influence of methysergide on 5-hydroxytryptamine-induced changes in regional distribution of blood flow. | Systemic and regional haemodynamic variables were measured at the baseline and after saline or 5-HT infusions (5 microgram kg-1 min-1, i.v.) or methysergide injections (0.5 mg kg-1, i.v.). Cardiac output and its complete distribution were measured by the radioactive microsphere (15 micrometer diam) technique. Although ... | The influence of methysergide on 5-hydroxytryptamine-induced changes in regional distribution of blood flow. Systemic and regional haemodynamic variables were measured at the baseline and after saline or 5-HT infusions (5 microgram kg-1 min-1, i.v.) or methysergide injections (0.5 mg kg-1, i.v.). Cardiac output and its... | [
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PMID:28414 | Pharmacology of 6,7-dihydroxy-2-dimethylaminotetralin (TL-99). I. Cardiovascular activity in the dog and cat. | 6,7-Dihydroxy-2-dimethylaminotetralin (TL-99), the 5,6-dihydroxy isomer (M-7) and dopamine were studied for cardiovascular activity in the cat and dog. TL-99 was found to be the most active of these compounds. Some of the more striking actions of TL-99 and M-7 were bradycardia, hypotension and complete blockade of nore... | Pharmacology of 6,7-dihydroxy-2-dimethylaminotetralin (TL-99). I. Cardiovascular activity in the dog and cat. 6,7-Dihydroxy-2-dimethylaminotetralin (TL-99), the 5,6-dihydroxy isomer (M-7) and dopamine were studied for cardiovascular activity in the cat and dog. TL-99 was found to be the most active of these compounds. ... | [
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PMID:28415 | Withdrawal of clonidine: effects of varying dosage or duration of treatment on subsequent blood pressure and heart rate responses. | The influence of the dosage or duration of treatment on the incidence and severity of clonidine withdrawal responses was examined in normotensive rats. Clonidine (0.01 or 0.1 mg/kg i.m.) was administered either in single doses, or twice daily for 3 days or 3 weeks. Rats were then anesthetized and arterial catheters wer... | Withdrawal of clonidine: effects of varying dosage or duration of treatment on subsequent blood pressure and heart rate responses. The influence of the dosage or duration of treatment on the incidence and severity of clonidine withdrawal responses was examined in normotensive rats. Clonidine (0.01 or 0.1 mg/kg i.m.) wa... | [
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PMID:28417 | The black physician's assistant: problems and prospects. | This is a report on a study of the social origins, attitudes, and anticipated practice settings of black and white recruits to the physician's assistant occupation. Recruits are generally representative of the larger black and white communities in their values; however, black recruits are more likely than their white c... | The black physician's assistant: problems and prospects. This is a report on a study of the social origins, attitudes, and anticipated practice settings of black and white recruits to the physician's assistant occupation. Recruits are generally representative of the larger black and white communities in their values; h... | [
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PMID:28421 | Suppression of mitogen responses and graft-versus-host reaction by splenocytes from mice bearing Lewis lung carcinoma. | The presence of suppressor cells in the spleens of C57BL/6 mice bearing Lewis lung carcinoma was investigated with the use of the in vitro lymphoproliferative response to mitogens and the graft-versus-host reaction (GVHR) as test systems. Splenocytes from tumor-bearing mice showed a lower response to mitogens when obta... | Suppression of mitogen responses and graft-versus-host reaction by splenocytes from mice bearing Lewis lung carcinoma. The presence of suppressor cells in the spleens of C57BL/6 mice bearing Lewis lung carcinoma was investigated with the use of the in vitro lymphoproliferative response to mitogens and the graft-versus-... | [
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PMID:28422 | Transfer of viable putative preneoplastic hepatocytes to the livers of syngeneic host rats. | A new approach was developed by which freshly isolated, chemical carcinogen-altered hepatocytes with the positive marker gamma-glutamyl transpeptidase (gamma-GT) could be transferred from adult donor F344 rats to the livers of syngeneic, adult host rats. Selective proliferation of gamma-GT-positive hepatocytes was indu... | Transfer of viable putative preneoplastic hepatocytes to the livers of syngeneic host rats. A new approach was developed by which freshly isolated, chemical carcinogen-altered hepatocytes with the positive marker gamma-glutamyl transpeptidase (gamma-GT) could be transferred from adult donor F344 rats to the livers of s... | [
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PMID:28424 | Prostatic maldevelopment in the prune belly syndrome: a defect in prostatic stromal-epithelial interaction. | The prune belly syndrome consists of a triad of abdominal wall musculature deficiency, cryptorchidism and urinary tract anomalies. A rarely described but fairly constant component of the syndrome is the lack of development of the epithelial elements of the prostate. We wish to suggest that this is a further expression ... | Prostatic maldevelopment in the prune belly syndrome: a defect in prostatic stromal-epithelial interaction. The prune belly syndrome consists of a triad of abdominal wall musculature deficiency, cryptorchidism and urinary tract anomalies. A rarely described but fairly constant component of the syndrome is the lack of d... | [
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PMID:28425 | Bone marrow transplantation for acute myeloblastic leukemia. | Fifty-seven patients with end-stage acute myeloblastic leukemia (AML) received a total of 65 bone marrow transplants between 1968 and 1976. Marrow from HLA genotypically identical allogeneic donors was administered to 32 patients, 13 received marrow from HLA-incompatible donors, donor-recipient HLA compatibility was un... | Bone marrow transplantation for acute myeloblastic leukemia. Fifty-seven patients with end-stage acute myeloblastic leukemia (AML) received a total of 65 bone marrow transplants between 1968 and 1976. Marrow from HLA genotypically identical allogeneic donors was administered to 32 patients, 13 received marrow from HLA-... | [
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PMID:28449 | Single-mouse urine collection and pH monitoring system. | A glass cage with minimal surface area was designed and used to house mice for 24-hour urine collections. An experiment was performed with a radio-labeled compound excreted in the urine to assess the collection efficiency of the cage. In this experiment 74.2 +/- 6.5% of the excreted radioactivity was recovered in the u... | Single-mouse urine collection and pH monitoring system. A glass cage with minimal surface area was designed and used to house mice for 24-hour urine collections. An experiment was performed with a radio-labeled compound excreted in the urine to assess the collection efficiency of the cage. In this experiment 74.2 +/- 6... | [
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PMID:28454 | Effects of two adrenergic beta-receptor blockers on the sleep cycle of the cat. | Sixteen hour polygraphic recordings (EEG, EOG and EMG) were obtained from 14 adult cats after intraperitoneal injections of propranolol (5 mg/kg) or pindolol (0.1 or 0.5 mg/kg). All injections moderately increased waking, which consisted mainly of a sedated drowsy stage. Both drugs also decreased deep slow wave sleep, ... | Effects of two adrenergic beta-receptor blockers on the sleep cycle of the cat. Sixteen hour polygraphic recordings (EEG, EOG and EMG) were obtained from 14 adult cats after intraperitoneal injections of propranolol (5 mg/kg) or pindolol (0.1 or 0.5 mg/kg). All injections moderately increased waking, which consisted ma... | [
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PMID:28456 | [Sialographic findings in inflammations of the salivary glands (author's transl)]. | The greatest part of all diseases of salivary glands are caused by inflammations. The differential diagnosis to other diseases, e.g. tumors, if of great importance. The sialography has hereby developed to an important diagnostic measurement. There is a discussion about the technique of the sialography and its simple pe... | [Sialographic findings in inflammations of the salivary glands (author's transl)]. The greatest part of all diseases of salivary glands are caused by inflammations. The differential diagnosis to other diseases, e.g. tumors, if of great importance. The sialography has hereby developed to an important diagnostic measurem... | [
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PMID:28457 | [Disorders of motility of the stomach and pylorus: pathological significance (author's transl)]. | Five different disorders of motility of the pyloric region may be distinguished if direction and velocity of chyme passing through the pylorus are taken into account: 1. Accelerated emptying of food and overacidification of the bulbus duodeni: 2. Bolus emptying of the stomach and rapid increasing hyperosmolarity in the... | [Disorders of motility of the stomach and pylorus: pathological significance (author's transl)]. Five different disorders of motility of the pyloric region may be distinguished if direction and velocity of chyme passing through the pylorus are taken into account: 1. Accelerated emptying of food and overacidification of... | [
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PMID:28480 | [Methods and problems of investigation of psychopharmacological effect illustrated by the comparison of a novel pyridylbenzodiazepine with diazepam (author's transl)]. | Comparison of two compounds being investigated should take into consideration the most comprehensive spectrum of all psychic variables affected. Consequently, besides 15 standardized investigational methods, three open methods, history, observation of behavior and in particular free exploration were used. The investiga... | [Methods and problems of investigation of psychopharmacological effect illustrated by the comparison of a novel pyridylbenzodiazepine with diazepam (author's transl)]. Comparison of two compounds being investigated should take into consideration the most comprehensive spectrum of all psychic variables affected. Consequ... | [
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PMID:28475 | [Effect of anions on inhibition of lactate dehydrogenase by pyruvate]. | The effect of anions Cl- and I- on structural and kinetic properties of LDH was investigated. It was shown that anions are specific inhibitors of LDH competing with pyruvate in the active ternary complex, LDHNADHpyq. The following dissociation constants for the anions were obtained from inhibition data: 0.4 +/- 0.02 an... | [Effect of anions on inhibition of lactate dehydrogenase by pyruvate]. The effect of anions Cl- and I- on structural and kinetic properties of LDH was investigated. It was shown that anions are specific inhibitors of LDH competing with pyruvate in the active ternary complex, LDHNADHpyq. The following dissociation const... | [
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PMID:28476 | [Acid-base properties and secondary structure of DNA in isoionic solutions]. | Potentiometric titration of DNA in the isoionic solutions has been investigated at different concentrations of the polymer. The intrinsic constants pKo of titrable groups corresponding to the two inflections in the titration curves were calculated by taking into account the electrostatic potential of the macroion. The ... | [Acid-base properties and secondary structure of DNA in isoionic solutions]. Potentiometric titration of DNA in the isoionic solutions has been investigated at different concentrations of the polymer. The intrinsic constants pKo of titrable groups corresponding to the two inflections in the titration curves were calcul... | [
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PMID:28477 | [Isolation of matrix RNA coding a tyrosine aminotransferase isoenzyme induced by hydrocortisone from rat liver polyribosomes]. | Messenger RNA (mRNA) capable of coding hydrocortisone induced isoenzyme of tyrosineaminotransferase (TAT) was isolated and purified approximately 5000 times. Highly specific rabbit antibodies to the isoenzyme were obtained. Using these antibodies a specific antibody immunoadsorbent with a high capacity for specific bin... | [Isolation of matrix RNA coding a tyrosine aminotransferase isoenzyme induced by hydrocortisone from rat liver polyribosomes]. Messenger RNA (mRNA) capable of coding hydrocortisone induced isoenzyme of tyrosineaminotransferase (TAT) was isolated and purified approximately 5000 times. Highly specific rabbit antibodies t... | [
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PMID:28478 | [Acid-base equilibrium of yellow lupine ferrileghemoglobin. potentiometric studies]. | Dissociation of ionizing groups in leghemoglobin from Lupinus Luteus in the wide pH range was studied by potentiometric titration. 16 + 8 groups were shown to the titrated at acid pH. One part of them are normally titrating groups and the other one is associated with some details of protein structure. At neutral pH 4 g... | [Acid-base equilibrium of yellow lupine ferrileghemoglobin. potentiometric studies]. Dissociation of ionizing groups in leghemoglobin from Lupinus Luteus in the wide pH range was studied by potentiometric titration. 16 + 8 groups were shown to the titrated at acid pH. One part of them are normally titrating groups and ... | [
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PMID:28479 | [Nature of the easily melted portions of DNA with a quasi-random base sequence]. | The influence of denaturation conditions upon the character of partial denaturation of DNA with random base distribution were thoroughly studied. Maps of partial DNA denaturation were obtained at T less than TAT for phage phiB DNA at pH 10.7 and 5.5; Tg9 DNA at pH 8.8; at T less than TAT for phiB DNA at pH 10.9 and Tg9... | [Nature of the easily melted portions of DNA with a quasi-random base sequence]. The influence of denaturation conditions upon the character of partial denaturation of DNA with random base distribution were thoroughly studied. Maps of partial DNA denaturation were obtained at T less than TAT for phage phiB DNA at pH 10... | [
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PMID:28483 | Impaired antibody response to pneumococcal vaccine after treatment for Hodgkin's disease. | To determine if a normal antibody response can develop after therapy for Hodgkin's disease, we immunized 53 patients and 10 normal controls with dodecavalent pneumococcal vaccine. Antibody concentrations three weeks after immunization (geometric mean of 11 serotypes) were 1566 ng of protein nitrogen per milliliter in c... | Impaired antibody response to pneumococcal vaccine after treatment for Hodgkin's disease. To determine if a normal antibody response can develop after therapy for Hodgkin's disease, we immunized 53 patients and 10 normal controls with dodecavalent pneumococcal vaccine. Antibody concentrations three weeks after immuniza... | [
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PMID:28486 | The positive inotropic effect of phenylephrine in the presence of propranolol. Increase in time to peak force and in relaxation time without increase in c-AMP. | The effects of phenylephrine on the shape of the contraction curve and on the cyclic adenosine 3',5'-monophosphate (c-AMP) content were studied in electrically driven (frequency 0.2 Hz) cat papillary muscles. All experiments were done in the presence of 1 micron propranolol in order to minimize interference from beta-a... | The positive inotropic effect of phenylephrine in the presence of propranolol. Increase in time to peak force and in relaxation time without increase in c-AMP. The effects of phenylephrine on the shape of the contraction curve and on the cyclic adenosine 3',5'-monophosphate (c-AMP) content were studied in electrically ... | [
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PMID:28488 | Isolation and properties of gamma-glutamyltranspeptidase from Morris hepatoma 5123D. | gamma-Glutamyltranspeptidase was purified 600-fold from Morris hepatoma 5123D by six-step procedure. Its apparent molecular weight estimated by centrifugation in sucrose gradient with Triton X-100 amounts to 108 000. Some dipeptides particularly glycylglycine and several amino acids considerably increase the enzyme act... | Isolation and properties of gamma-glutamyltranspeptidase from Morris hepatoma 5123D. gamma-Glutamyltranspeptidase was purified 600-fold from Morris hepatoma 5123D by six-step procedure. Its apparent molecular weight estimated by centrifugation in sucrose gradient with Triton X-100 amounts to 108 000. Some dipeptides pa... | [
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PMID:28490 | Comparative study of miscellaneous properties of cysteine sulfinate transaminase and glutamate oxaloacetate transaminase in chick retina homogenate. | The activity, properties, and developmental pattern of cysteine sulfinate transaminase (CSA-T) were studied in chick retina and compared with the activity, properties, and developmental pattern of glutamate oxaloacetate transaminase (GOT). Their optimum pH is identical whereas the effect of pyridoxal phosphate seems to... | Comparative study of miscellaneous properties of cysteine sulfinate transaminase and glutamate oxaloacetate transaminase in chick retina homogenate. The activity, properties, and developmental pattern of cysteine sulfinate transaminase (CSA-T) were studied in chick retina and compared with the activity, properties, and... | [
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PMID:28491 | Acid proteinase of hypothalamus. Purification, some properties, and action on somatostatin and substance P. | In a continuing study of the physiological role of protein breakdown in the hypothalamus, acid proteinase from bovine hypothalamus was purified about 1000-fold. The molecular weight of the enzyme was approximately 50,000. Masimal activity against hemoglobin was obtained at pH 3.2-3.5; serum albumin was split much more ... | Acid proteinase of hypothalamus. Purification, some properties, and action on somatostatin and substance P. In a continuing study of the physiological role of protein breakdown in the hypothalamus, acid proteinase from bovine hypothalamus was purified about 1000-fold. The molecular weight of the enzyme was approximatel... | [
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PMID:28500 | The pharmacologic inhibition of premature labor. | Oxytocin, elevated estrogen-progesterone ratio, fetal corticosteroids, prostaglandins, catecholamines, and changes in uterine blood flow have all been implicated as triggers of labor. In approximately one-third of cases of threatened premature labor contractions stop spontaneously. Thus placebo-controlled randomized tr... | The pharmacologic inhibition of premature labor. Oxytocin, elevated estrogen-progesterone ratio, fetal corticosteroids, prostaglandins, catecholamines, and changes in uterine blood flow have all been implicated as triggers of labor. In approximately one-third of cases of threatened premature labor contractions stop spo... | [
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PMID:28501 | Studies on vaginal malodor. I. Study in humans. | Forty-two percent of collagen sponges tested as an intravaginal barrier contraceptive method developed malodor when retained for 5 days. Only 4% developed odor when the sponge was removed within 24 hours after intercourse, rinsed, and reinserted. While sexually active volunteers found odor in 37% of the sponges, odor f... | Studies on vaginal malodor. I. Study in humans. Forty-two percent of collagen sponges tested as an intravaginal barrier contraceptive method developed malodor when retained for 5 days. Only 4% developed odor when the sponge was removed within 24 hours after intercourse, rinsed, and reinserted. While sexually active vol... | [
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PMID:28503 | The uses of endodontic implant stabilizers in posttraumatic and periodontal disease. | Use of the endodontic implant stabilizer presents a sound physiologic procedure for stabilizing mobile teeth. It can increase root length, alter rootcrown ratios, immobilize fractured roots and periodontally compromised teeth, or supply combinations of these benefits. Case selection, operative technique, and case repor... | The uses of endodontic implant stabilizers in posttraumatic and periodontal disease. Use of the endodontic implant stabilizer presents a sound physiologic procedure for stabilizing mobile teeth. It can increase root length, alter rootcrown ratios, immobilize fractured roots and periodontally compromised teeth, or suppl... | [
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PMID:28507 | Bromsulphthalein retention test and gamma-glutamyl transpeptidase activity in the investigation of liver disease. | The usefulness of serum gamma-glutamyl transpeptidase activity (gammaGT) was studied in 39 patients on whom a bromsulphthalein retention test (BSP) was performed. In most patients, the potentially hazardous BSP test did not give any further evidence of hepatic disease over conventional hepatic function tests and the ga... | Bromsulphthalein retention test and gamma-glutamyl transpeptidase activity in the investigation of liver disease. The usefulness of serum gamma-glutamyl transpeptidase activity (gammaGT) was studied in 39 patients on whom a bromsulphthalein retention test (BSP) was performed. In most patients, the potentially hazardous... | [
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PMID:28505 | [Increased resistance of streptococcus pneumoniae to antibiotics and prevalence of their capsular serotypes (author's transl)]. | From January 1970 to December 1976, 867 strains of Streptococcus pneumoniae isolated from clinical specimens were routinely typed and tested for sensitivity to 12 antibiotics. The prevalent serotypes were 19, 23, 6, 3, 7 and 14. Twenty seven p. cent of the strains were found resistant to tetracycline, and 4,2% were res... | [Increased resistance of streptococcus pneumoniae to antibiotics and prevalence of their capsular serotypes (author's transl)]. From January 1970 to December 1976, 867 strains of Streptococcus pneumoniae isolated from clinical specimens were routinely typed and tested for sensitivity to 12 antibiotics. The prevalent se... | [
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PMID:28509 | Increases of guanosine 3',5'-monophosphate-related enzymes in kidneys of developing rats. | Guanylate cyclase, cGMP phosphodiesterase and protein kinase activities were determined in kidneys of developing and adult rats. Guanylate cyclase activities of crude kidney homogenates, 100,000 x g supernatant and pellet of 7- and 21-day-old and adult rats were determined (Table I). In the kidneys of 7-day-old rats ac... | Increases of guanosine 3',5'-monophosphate-related enzymes in kidneys of developing rats. Guanylate cyclase, cGMP phosphodiesterase and protein kinase activities were determined in kidneys of developing and adult rats. Guanylate cyclase activities of crude kidney homogenates, 100,000 x g supernatant and pellet of 7- an... | [
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PMID:28510 | Fatal graft-versus-host disease after a small leukocyte transfusion in a patient with lymphoma and varicella. | A child with a poorly differentiated lymphoma developed varicella while being treated with maintenance chemotherapeutic agents. He received a transfusion of nonirradiated leukocytes from 1 unit of whole blood donated by a healthy volunteer who had recently recovered from varicella. The clinical course of varicella was ... | Fatal graft-versus-host disease after a small leukocyte transfusion in a patient with lymphoma and varicella. A child with a poorly differentiated lymphoma developed varicella while being treated with maintenance chemotherapeutic agents. He received a transfusion of nonirradiated leukocytes from 1 unit of whole blood d... | [
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PMID:28512 | Action and interaction of perivascular H+, K+ and Ca++ on pial arteries. | In cats the perivascular space of small pial arteries was perfused with mock CSF by means of micropipettes. Variations of K+, H+ and Ca++ activities in the perfusate cause changes of the diameters of the affected vessels. Increases of H+ and moderate increases of K+ lead to dilatations, Ca++ -increases elicit constrict... | Action and interaction of perivascular H+, K+ and Ca++ on pial arteries. In cats the perivascular space of small pial arteries was perfused with mock CSF by means of micropipettes. Variations of K+, H+ and Ca++ activities in the perfusate cause changes of the diameters of the affected vessels. Increases of H+ and moder... | [
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PMID:28514 | Effect of benzolamide on luminal pH in proximal convoluted tubules of the rat kidney. | Luminal pH in early and late proximal tubules was recorded continuously with antimony microelectrodes before and during carbonic anhydrase inhibition. Following i.v. application of benzolamide (25 mumol/kg BW), luminal pH decreased almost immediately in early proximal tubules (deltapH--0.42 +/- 0.06SEM), but increased ... | Effect of benzolamide on luminal pH in proximal convoluted tubules of the rat kidney. Luminal pH in early and late proximal tubules was recorded continuously with antimony microelectrodes before and during carbonic anhydrase inhibition. Following i.v. application of benzolamide (25 mumol/kg BW), luminal pH decreased al... | [
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PMID:28516 | Photodissociable dimer reduction products of 2-thiopyrimidine derivatives. | Both 4,6-dimethyl-2-thipyrimidine and its 1-methyl derivative undergo polarographic reduction in aqueous medium, via a 1e/1H+ reduction to a free radical which rapidly dimerizes to products isolates and identified as 4,4'-bis-(4,6-dimethyl-3,4-dihydropyrimidin-2-thione) and the corresponding 1-methyl dimer. The dimers ... | Photodissociable dimer reduction products of 2-thiopyrimidine derivatives. Both 4,6-dimethyl-2-thipyrimidine and its 1-methyl derivative undergo polarographic reduction in aqueous medium, via a 1e/1H+ reduction to a free radical which rapidly dimerizes to products isolates and identified as 4,4'-bis-(4,6-dimethyl-3,4-d... | [
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PMID:28517 | Skin closure with polyglycolic acid (Dexon). | Cosmetically satisfactory scars were achieved in 94.5% of skin crease orchidopexy wounds sutured with subcuticular polyglycolic acid. Of twenty-seven similar wounds closed with interrupted black silk sutures 18.5% developed hypertrophy at the medial end. | Skin closure with polyglycolic acid (Dexon). Cosmetically satisfactory scars were achieved in 94.5% of skin crease orchidopexy wounds sutured with subcuticular polyglycolic acid. Of twenty-seven similar wounds closed with interrupted black silk sutures 18.5% developed hypertrophy at the medial end. | [
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PMID:28520 | Rat liver microsomal and lysosomal beta-glucuronidases differ in both carbohydrate and amino acid compositions. | To investigate the chemical relationships between rat liver lysosomal and microsomal beta-D-glucuronidases (EC 3.2.1.31), which are essentially identical catalytically and in reactivity with antibody and similar in molecular weight, the two enzymes were isolated by procedures in which modifications of the proteins were... | Rat liver microsomal and lysosomal beta-glucuronidases differ in both carbohydrate and amino acid compositions. To investigate the chemical relationships between rat liver lysosomal and microsomal beta-D-glucuronidases (EC 3.2.1.31), which are essentially identical catalytically and in reactivity with antibody and simi... | [
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PMID:28521 | Demonstration of high-affinity folate binding activity associated with the brush border membranes of rat kidney. | Folate binding activity of high affinity was identified in the particulate fractions of rat kidney homogenates. This binding activity cofractionated with alkaline phosphatase and maltase, two brush border membranes markers. With an enriched preparation of brush border membranes, freed of endogenous folate by acid treat... | Demonstration of high-affinity folate binding activity associated with the brush border membranes of rat kidney. Folate binding activity of high affinity was identified in the particulate fractions of rat kidney homogenates. This binding activity cofractionated with alkaline phosphatase and maltase, two brush border me... | [
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PMID:28522 | Allosteric regulation of monocyclic interconvertible enzyme cascade systems: use of Escherichia coli glutamine synthetase as an experimental model. | The interconversion of Escherichia coli glutamine synthetase [L-glutamate:ammonia ligase (ADP-forming), EC 6.3.1.2] between its adenylylated and unadenylylated forms has been used to verify the prediction derived from a theoretical analysis of the steady-state functions of a model for a monocyclic interconvertible enzy... | Allosteric regulation of monocyclic interconvertible enzyme cascade systems: use of Escherichia coli glutamine synthetase as an experimental model. The interconversion of Escherichia coli glutamine synthetase [L-glutamate:ammonia ligase (ADP-forming), EC 6.3.1.2] between its adenylylated and unadenylylated forms has be... | [
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PMID:28523 | Interaction of methotrexate, folates, and pyridine nucleotides with dihydrofolate reductase: calorimetric and spectroscopic binding studies. | The thermodynamic parameters, deltaG, deltaH, and deltaS characterizing the tight binding of methotrexate, folates, and pyridine nucleotides to chicken liver dihydrofolate reductase (5,6,7,8-tetrahydrofolate: NADP+ oxidoreductase, EC 1.5.1.3) have been determined from calorimetric and fluorescence measurements. At 25 d... | Interaction of methotrexate, folates, and pyridine nucleotides with dihydrofolate reductase: calorimetric and spectroscopic binding studies. The thermodynamic parameters, deltaG, deltaH, and deltaS characterizing the tight binding of methotrexate, folates, and pyridine nucleotides to chicken liver dihydrofolate reducta... | [
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PMID:28524 | Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents. | A quantitative method is described for the measurement of intralysosomal pH in living cells. Fluorescein isothiocyanate-labeled dextran (FD) is endocytized and accumulates in lysosomes where it remains without apparent degradation. The fluorescence spectrum of this compound changes with pH in the range 4-7 and is not s... | Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents. A quantitative method is described for the measurement of intralysosomal pH in living cells. Fluorescein isothiocyanate-labeled dextran (FD) is endocytized and accumulates in lysosomes where it remains ... | [
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PMID:28525 | Physicochemical characterization of six monoclonal cryoimmunoglobulins: possible basis for cold-dependent insolubility. | The physical and chemical properties of five human and one canine monoclonal cryoimmunoglobulin have been compared. By many criteria, the proteins cannot be distinguished from the noncryoglobulin reference proteins analyzed in parallel; however, certain hydrodynamic and spectroscopic properties of the proteins indicate... | Physicochemical characterization of six monoclonal cryoimmunoglobulins: possible basis for cold-dependent insolubility. The physical and chemical properties of five human and one canine monoclonal cryoimmunoglobulin have been compared. By many criteria, the proteins cannot be distinguished from the noncryoglobulin refe... | [
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PMID:28526 | Nerve growth factor-induced fiber outgrowth from isolated rat adrenal chromaffin cells: impairment by glucocorticoids. | Addition of nerve growth factor to cultures of dissociated rat adrenal medullary cells caused fiber outgrowth from chromaffin cells. These fibers exhibited all the characteristics of neurites, particularly the formation of typical growth cones exhibiting intense catecholamine-specific fluorescence. Because this nerve g... | Nerve growth factor-induced fiber outgrowth from isolated rat adrenal chromaffin cells: impairment by glucocorticoids. Addition of nerve growth factor to cultures of dissociated rat adrenal medullary cells caused fiber outgrowth from chromaffin cells. These fibers exhibited all the characteristics of neurites, particul... | [
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PMID:28527 | Presynaptic modulation of voltage-dependent Ca2+ current: mechanism for behavioral sensitization in Aplysia californica. | Behavioral sensitization of the gill-withdrawal reflex of Aplysia is the result of a prolonged increase in transmitter release from the presynaptic terminals of sensory neurons. Earlier work suggested that this presynaptic facilitation might be mediated by a serotonin-sensitive adenylate cyclase in the sensory neuron t... | Presynaptic modulation of voltage-dependent Ca2+ current: mechanism for behavioral sensitization in Aplysia californica. Behavioral sensitization of the gill-withdrawal reflex of Aplysia is the result of a prolonged increase in transmitter release from the presynaptic terminals of sensory neurons. Earlier work suggeste... | [
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PMID:28534 | Hydrolysis of cephalosporins in strongly acid medium. | The hydrolysis of cephalexin, cephalothin and cephaloridine in strongly acid medium (10--25% sulfuric acid) at high temperature (approximately 100 degrees C) was studied. The hydrolysis proceeds with a high rate (10--15 min are necessary for complete hydrolysis) and results in definite products with low mol.-wt. The hy... | Hydrolysis of cephalosporins in strongly acid medium. The hydrolysis of cephalexin, cephalothin and cephaloridine in strongly acid medium (10--25% sulfuric acid) at high temperature (approximately 100 degrees C) was studied. The hydrolysis proceeds with a high rate (10--15 min are necessary for complete hydrolysis) and... | [
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PMID:28539 | A study in mice of benzodiazephine-anticholinergic interaction: protection against restraint-immersion and forced exertion-induced gastric mucosal erosion. | The effectiveness of benzodiazepines and anticholinergics administered alone or in combination in preventing restraint-immersion and forced exertion-induced gastric mucosal erosion was investigated in mice. The benzodiazepines used were diazepam and chlordiazepoxide HCI and the anticholinergics were propantheline bromi... | A study in mice of benzodiazephine-anticholinergic interaction: protection against restraint-immersion and forced exertion-induced gastric mucosal erosion. The effectiveness of benzodiazepines and anticholinergics administered alone or in combination in preventing restraint-immersion and forced exertion-induced gastric... | [
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PMID:28544 | Tardive dyskinesia and psychotropic drug history. | The adult population of a large mental hospital was screened for tardive dyskinesia (TD). Approximately 11% of the hospital population showed signs of TD; females and the elderly were over-represented in the TD group. A representative sample of those with TD was selected and a control (non-TD) patient was chosen to mat... | Tardive dyskinesia and psychotropic drug history. The adult population of a large mental hospital was screened for tardive dyskinesia (TD). Approximately 11% of the hospital population showed signs of TD; females and the elderly were over-represented in the TD group. A representative sample of those with TD was selecte... | [
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PMID:28545 | The effects of a new benzodiazepine derivative, ID-540, on the averaged photopalpebral reflex in man. | The effects of 7-chloro-5-(2-fluorophenyl)-1-methyl-1 H, 1.4-benzodiazepin-2(3H)-one (ID-540), a recently introduced benzodiazepine derivative, on the averaged photopalpebral reflex (PPR), subjective symptoms, and serum levels of ID-540 and its principal metabolite, N-desmethyl-ID-540, following an oral dose of 0.5 mg ... | The effects of a new benzodiazepine derivative, ID-540, on the averaged photopalpebral reflex in man. The effects of 7-chloro-5-(2-fluorophenyl)-1-methyl-1 H, 1.4-benzodiazepin-2(3H)-one (ID-540), a recently introduced benzodiazepine derivative, on the averaged photopalpebral reflex (PPR), subjective symptoms, and seru... | [
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PMID:28546 | Neuroleptic interference with the cocaine cue: internal stimulus control of behavior and psychosis. | The ability of cocaine to exert internal stimulus control of behavior was investigated by training rats to discriminate 10 mg/kg cocaine from saline in a discrete-trial, two-lever, food-reward procedure. Acquisition of response control by cocaine (1) succeeded in all animals tested, (2) proceeded rapidly, and (3) was a... | Neuroleptic interference with the cocaine cue: internal stimulus control of behavior and psychosis. The ability of cocaine to exert internal stimulus control of behavior was investigated by training rats to discriminate 10 mg/kg cocaine from saline in a discrete-trial, two-lever, food-reward procedure. Acquisition of r... | [
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PMID:28549 | [The periarteritis nodosa--diagnosted by angiography. A case with multiple aneurysms (author's transl)]. | Periarteritis nodosa is a severe systemic disease which is characterized by an inflammation of the vessel walls and a high incidence of renal involvement. Angiography should be performed immediately when clinical suspicion is aroused. Angiography is superior to the results of skin and muscles biopsy and gives informati... | [The periarteritis nodosa--diagnosted by angiography. A case with multiple aneurysms (author's transl)]. Periarteritis nodosa is a severe systemic disease which is characterized by an inflammation of the vessel walls and a high incidence of renal involvement. Angiography should be performed immediately when clinical su... | [
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PMID:28550 | [Radiolytic decontamination of Di-n-butyl phthalate from water (author's transl)]. | Recently, a considerable amount of phthalic acid esters (PAE), the most widely utilized plasticizer, has been released into and polluted the environment. Since their toxicity and teratogenicity, although fairly low, to experimental animals have recently been shown, the removal of them from the environment, especially f... | [Radiolytic decontamination of Di-n-butyl phthalate from water (author's transl)]. Recently, a considerable amount of phthalic acid esters (PAE), the most widely utilized plasticizer, has been released into and polluted the environment. Since their toxicity and teratogenicity, although fairly low, to experimental anima... | [
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PMID:28553 | Rat brain gamma-glutamyl transpeptidase: effects of alcohol. | Adult rats were exposed to increasing air ethanol concentrations over a 12-day period without the use of pyrazole. Gamma-glutamyl transpeptidase levels were determined from various regions of rat brain. The enzyme levels in the pons-medulla, mid-brain and the striatum increased significantly during the 12-day exposure ... | Rat brain gamma-glutamyl transpeptidase: effects of alcohol. Adult rats were exposed to increasing air ethanol concentrations over a 12-day period without the use of pyrazole. Gamma-glutamyl transpeptidase levels were determined from various regions of rat brain. The enzyme levels in the pons-medulla, mid-brain and the... | [
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PMID:28554 | Tyrosine hydroxylase activity in brain regions after intraventricular 6-hydroxydopamine in the neonatal rat. | Intraventricular 6-OHDA treatment to newborn rats produced a marked reduction in tyrosine hydroxylase activity in most brain regions at maturity which correlated moderately well with the catecholamine levels. However, those regions in which NE levels were increased did not show a corresponding increase in total tyrosin... | Tyrosine hydroxylase activity in brain regions after intraventricular 6-hydroxydopamine in the neonatal rat. Intraventricular 6-OHDA treatment to newborn rats produced a marked reduction in tyrosine hydroxylase activity in most brain regions at maturity which correlated moderately well with the catecholamine levels. Ho... | [
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PMID:28555 | Effect of benzodiazepines on age of vaginal perforation and first estrus in mice. | Female mice which received chlordiazepoxide, diazepam, oxazepam, prazepam, flurazepam, or nitrazepam prenatally and postnatally had delays in the age of vaginal perforation and first estrus concomitant with reduced postnatal growth. Females exposed prenatally showed no growth deficits, but in four treatments had delaye... | Effect of benzodiazepines on age of vaginal perforation and first estrus in mice. Female mice which received chlordiazepoxide, diazepam, oxazepam, prazepam, flurazepam, or nitrazepam prenatally and postnatally had delays in the age of vaginal perforation and first estrus concomitant with reduced postnatal growth. Femal... | [
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PMID:28556 | Histamine receptors of airway smooth muscle of ferret and rat. | Ferret trachea and bronchus contract to carbachol greater than 5-HT greater than bradykinin (BK) greater than PGF2alpha greater than histamine greater than 2-methylhistamine (2-MeH: a specific H1-receptor agonist). Rat trachea is insensitive to the spasmogenic actions of histamine, 2-MeH, PGF2alpha, BK and 5-HT. Ferret... | Histamine receptors of airway smooth muscle of ferret and rat. Ferret trachea and bronchus contract to carbachol greater than 5-HT greater than bradykinin (BK) greater than PGF2alpha greater than histamine greater than 2-methylhistamine (2-MeH: a specific H1-receptor agonist). Rat trachea is insensitive to the spasmoge... | [
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PMID:28559 | The heart production in energy-depleted human erythrocytes induced by glucose, inosine and adenine. | The heat production (HP) of glucose deprived human red blood cells was measured, using glucose, adenine and inosine as substrates. Inosine induced a significantly higher HP than glucose and adenine induced no significant HP. At low pH the HP of glucose decreased more than that of inosine, corresponding to an equally lo... | The heart production in energy-depleted human erythrocytes induced by glucose, inosine and adenine. The heat production (HP) of glucose deprived human red blood cells was measured, using glucose, adenine and inosine as substrates. Inosine induced a significantly higher HP than glucose and adenine induced no significant... | [
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PMID:28561 | beta-lactamases in bacteroides. | Bacteroides fragilis is responsible for most anaerobic infections in man. Most isolates of B. fragilis show resistance to beta-lactam antibiotics. This resistance might be due to beta-lactamase production or permeability barrier in the cell wall. B. fragilis produce beta-lactamase with mainly cephalosporinase activity.... | beta-lactamases in bacteroides. Bacteroides fragilis is responsible for most anaerobic infections in man. Most isolates of B. fragilis show resistance to beta-lactam antibiotics. This resistance might be due to beta-lactamase production or permeability barrier in the cell wall. B. fragilis produce beta-lactamase with m... | [
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PMID:28565 | [The mucocutaneous and lymph node syndrome of Kawasaki. 1 case complicated by multiple aneurysms]. | We report in a five month old baby a case of the cutaneomucosal and lymph node syndrome described by Kawasaki, remarkable for the onset of multiple aneurysms involving the coronary and the limb arteries. This syndrome has rarely been observed except in Japan where it seems frequent. Possibly is benign forms, without he... | [The mucocutaneous and lymph node syndrome of Kawasaki. 1 case complicated by multiple aneurysms]. We report in a five month old baby a case of the cutaneomucosal and lymph node syndrome described by Kawasaki, remarkable for the onset of multiple aneurysms involving the coronary and the limb arteries. This syndrome has... | [
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PMID:28568 | Granulomatous hepatitis associated with salicylazosulfapyridine therapy. | Granulomatous hepatitis has been associated with many conditions, including chronic ulcerative colitis and sulfonamide therapy. We report a patient with ulcerative colitis in whom hepatic granulomatosis was associated with salicylazosulfapyridine (Azulfidine). Sulfonamides should be considered a possible cause of hepat... | Granulomatous hepatitis associated with salicylazosulfapyridine therapy. Granulomatous hepatitis has been associated with many conditions, including chronic ulcerative colitis and sulfonamide therapy. We report a patient with ulcerative colitis in whom hepatic granulomatosis was associated with salicylazosulfapyridine ... | [
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PMID:28592 | Histopathology of hepatic acute graft-versus-host disease in the dog. A double blind study confirms the specificity of small bile duct lesions. | To test the association of small bile duct destructive lesions in the liver with acute graft-versus-host disease, a blind (coded) histological study was done comparing liver tissue from three groups of dogs given 1,200 R of total-body irradiation: one not given marrow infusions after irradiation, another given autolog... | Histopathology of hepatic acute graft-versus-host disease in the dog. A double blind study confirms the specificity of small bile duct lesions. To test the association of small bile duct destructive lesions in the liver with acute graft-versus-host disease, a blind (coded) histological study was done comparing liver t... | [
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PMID:28593 | [Activity of NADP-dependent glycerol-3-phosphate dehydrogenase in skeletal muscles of animals]. | The NADP-dependent glycerol-3-phosphate dehydrogenase activity was studied in sketetal muscles of the rat, rabbit and frog. The dehydrogenase activity in the skeletal muscles of the rat and rabbit was higher than that of the frog. The enzyme activity was found to depend upon the buffer, being higher in tris-HCl buffer ... | [Activity of NADP-dependent glycerol-3-phosphate dehydrogenase in skeletal muscles of animals]. The NADP-dependent glycerol-3-phosphate dehydrogenase activity was studied in sketetal muscles of the rat, rabbit and frog. The dehydrogenase activity in the skeletal muscles of the rat and rabbit was higher than that of the... | [
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PMID:28600 | Megalourethra. | Two cases of megalourethra are presented, the ninth and tenth cases to be documented in the literature. Both patients exhibited mesodermal abnormalities which justify categorization among the minor forms of prune belly syndrome. One patient, the youngest to have undergone surgical correction, presented with azotemia, d... | Megalourethra. Two cases of megalourethra are presented, the ninth and tenth cases to be documented in the literature. Both patients exhibited mesodermal abnormalities which justify categorization among the minor forms of prune belly syndrome. One patient, the youngest to have undergone surgical correction, presented w... | [
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PMID:28601 | Crossed renal ectopia with familial occurrence. | A familial occurrence of crossed renal ectopia is presented. No genetic factor has been determined in this congenital anomaly so this familial occurrence is believed to be incidental. | Crossed renal ectopia with familial occurrence. A familial occurrence of crossed renal ectopia is presented. No genetic factor has been determined in this congenital anomaly so this familial occurrence is believed to be incidental. | [
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PMID:28602 | True prostatic tissue in 46,XX female with adrenogenital syndrome. | A case is presented of a seventeen-year-old phenotypic male with empty scrotum, hormonal studies consistent with adrenogenital syndrome, a 46,XX karyotype, and a normal prostate on rectal examination. Histochemical evidence of the true nature of the prostatic tissue is presented, and the developmental aspects of the ca... | True prostatic tissue in 46,XX female with adrenogenital syndrome. A case is presented of a seventeen-year-old phenotypic male with empty scrotum, hormonal studies consistent with adrenogenital syndrome, a 46,XX karyotype, and a normal prostate on rectal examination. Histochemical evidence of the true nature of the pro... | [
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PMID:28610 | [An inverse reaction of the ST-T complex in the elctrocardiogram due to beta receptor inhibition]. | In this article shall be referred to a special form of reaction of the ST-T-complexes in the propranolol test. Instead of a normalisation of this section of the ECG an inverse reaction develops. It consists in the fact that after application of propranolol the negativities of the T-waves increase and the lowerings of t... | [An inverse reaction of the ST-T complex in the elctrocardiogram due to beta receptor inhibition]. In this article shall be referred to a special form of reaction of the ST-T-complexes in the propranolol test. Instead of a normalisation of this section of the ECG an inverse reaction develops. It consists in the fact th... | [
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PMID:28611 | [Empirical examination of training programs for the treatment of speech anxiety]. | This study is the result of an attempt to get effective methods in order to reduce the students' speaking anxiety in seminars. In a prepost-design, two training programs are compared: systematic desensitization and assertive training. Success is controlled with the help of a subjective anxiety scale, the "Freiburger Pe... | [Empirical examination of training programs for the treatment of speech anxiety]. This study is the result of an attempt to get effective methods in order to reduce the students' speaking anxiety in seminars. In a prepost-design, two training programs are compared: systematic desensitization and assertive training. Suc... | [
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PMID:28607 | [Pancreatic exocrine secretion to the introduction into the blood of amino acid mixtures of varying composition]. | Tests conducted on dogs with a fistula of the pancreatic duct evidenced that various amino acids mixtures containing all the essential amino acids and differing mainly in the replaceable nitrogen dissimilarly act on the external secretion of the pancreas after their introduction into the blood. The most intensive secre... | [Pancreatic exocrine secretion to the introduction into the blood of amino acid mixtures of varying composition]. Tests conducted on dogs with a fistula of the pancreatic duct evidenced that various amino acids mixtures containing all the essential amino acids and differing mainly in the replaceable nitrogen dissimilar... | [
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PMID:28609 | Phenobarbital increases spontaneous transmitter release at the frog neuromuscular junction. | Phenobarbital (1-2 × 10(-4)M) markedly increases the frequency of miniature end-plate potentials at the neuromuscular synapse of the frog. This effect was seen in calcium free media containing EGTA. The drug probably acts presynaptically at an intracellular locus to increase the presynaptic free calcium concentration. | Phenobarbital increases spontaneous transmitter release at the frog neuromuscular junction. Phenobarbital (1-2 × 10(-4)M) markedly increases the frequency of miniature end-plate potentials at the neuromuscular synapse of the frog. This effect was seen in calcium free media containing EGTA. The drug probably acts presyn... | [
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PMID:28615 | Influence of sodium tripolyphosphate and citric acid on the shelf life of thornback ray (Raja clavata L.). | Sodium tripolyphosphate dips (5 min in 12% solution) extended shelf life of thornback ray wings by about 2 days, improved the appearance and eliminated weight losses. With citric acid dips (5 min in 0.5% solution) a 3 day extension of storage life was obtained but the treatment had a slight bleaching effect and caused ... | Influence of sodium tripolyphosphate and citric acid on the shelf life of thornback ray (Raja clavata L.). Sodium tripolyphosphate dips (5 min in 12% solution) extended shelf life of thornback ray wings by about 2 days, improved the appearance and eliminated weight losses. With citric acid dips (5 min in 0.5% solution)... | [
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PMID:28618 | [Post mortem determination of bromureides (author's transl)]. | Concentrations of carbromal, carbromide and bromisoval are determined in blood, urine, brain, kidney and muscle taken at autopsy from 41 fatal cases after overdosage of bromureides. In addition values of total bromine in blood are presented. Contents of total bromine can only lead to the deduction that a chronical abus... | [Post mortem determination of bromureides (author's transl)]. Concentrations of carbromal, carbromide and bromisoval are determined in blood, urine, brain, kidney and muscle taken at autopsy from 41 fatal cases after overdosage of bromureides. In addition values of total bromine in blood are presented. Contents of tota... | [
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PMID:28620 | Utilization of industrial and agricultural by-products for fungal amylase production. | Attempts were made for using industrial and agricultural by-products and wastes as carbon and nitrogen sources in fermentation medium for alpha-amylase production by Aspergillus niger NRRL-337. The original carbon source of the basal medium was replaced by one of the following materials: rice bran, wheat bran, corn bra... | Utilization of industrial and agricultural by-products for fungal amylase production. Attempts were made for using industrial and agricultural by-products and wastes as carbon and nitrogen sources in fermentation medium for alpha-amylase production by Aspergillus niger NRRL-337. The original carbon source of the basal ... | [
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PMID:28624 | [Experiences with continuous fetal measurements during pregnancy]. | Experiences by continuous ultrasonic measurements during pregnancy. The authors have published earlier a diagram for use to evaluate the fetal development. The aptitude in practice has been proved.--To evaluate normal fetal growth the percentiles curves of Lubchenco are less suitable than of the GDR. But also the last ... | [Experiences with continuous fetal measurements during pregnancy]. Experiences by continuous ultrasonic measurements during pregnancy. The authors have published earlier a diagram for use to evaluate the fetal development. The aptitude in practice has been proved.--To evaluate normal fetal growth the percentiles curves... | [
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PMID:28619 | [Benorylate and indomethacin in cervical syndromes: a comparative double-blind study]. | In a double-blind study the effectiveness of benorylate and indomethacin was compared in patients suffering from cervical spine syndromes. From a total of 60 patients, 30 individuals (group A) received 100 mg of indomethacin/day and 30 (group B) were treated with 6 g of benorylate per day. Clinical improvement as judge... | [Benorylate and indomethacin in cervical syndromes: a comparative double-blind study]. In a double-blind study the effectiveness of benorylate and indomethacin was compared in patients suffering from cervical spine syndromes. From a total of 60 patients, 30 individuals (group A) received 100 mg of indomethacin/day and ... | [
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PMID:28625 | [Significance of a general umbilical-cord pH for the evaluation of acidosis morbidity]. | The value of a general pH analysis of the artery umbilicalis as a parameter of the postnatal diagnostic of the newborns is shown. The classification of the values in different grades of acidity and the relation to the Apgar score show, that the light and middle-heavy acidoses are not determined sufficiently by the Apga... | [Significance of a general umbilical-cord pH for the evaluation of acidosis morbidity]. The value of a general pH analysis of the artery umbilicalis as a parameter of the postnatal diagnostic of the newborns is shown. The classification of the values in different grades of acidity and the relation to the Apgar score sh... | [
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PMID:28628 | [In vitro effect of psychopharmacologic drugs on the embryonic brain tissue of the fetuses of schizophrenic mothers]. | The author studied the influence on the adaptation of the nervous tissue explantations from 25 fetuses of schizophrenic mothers and a similar amount of fetuses from normal women (embryonal development--7-12 weeks) during the initial period of explantation in vitro (5-6 days) with 10 psychopharmacological preparations (... | [In vitro effect of psychopharmacologic drugs on the embryonic brain tissue of the fetuses of schizophrenic mothers]. The author studied the influence on the adaptation of the nervous tissue explantations from 25 fetuses of schizophrenic mothers and a similar amount of fetuses from normal women (embryonal development--... | [
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PMID:28629 | Regulation of anaerobic glycolysis in Ehrlich ascites tumour cells. | 1) In intact Ehrlich ascites tumour cells the anaerobic glycolytic flux rate and pattern of intermediates have been investigated at different pH values of the extracellular medium. 2) As predicted from the dependence of the lactic acid dehydrogenase equilibrium on pH a strong negative correlation between log ([lactate]... | Regulation of anaerobic glycolysis in Ehrlich ascites tumour cells. 1) In intact Ehrlich ascites tumour cells the anaerobic glycolytic flux rate and pattern of intermediates have been investigated at different pH values of the extracellular medium. 2) As predicted from the dependence of the lactic acid dehydrogenase eq... | [
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PMID:28630 | The haemodynamic effects of sodium nitroprusside-induced hypotension during beta-adrenergic blockade and anaesthesia. A case report. | We present the central haemodynamic data obtained during halothane/nitrous oxide anaesthesia in a patient under antihypertensive treatment with propranolol who underwent surgery for intracranial aneurysms in sodium nitroprusside-induced hypotension. Cardiac output remained unchanged when hypotension was induced. Pulmon... | The haemodynamic effects of sodium nitroprusside-induced hypotension during beta-adrenergic blockade and anaesthesia. A case report. We present the central haemodynamic data obtained during halothane/nitrous oxide anaesthesia in a patient under antihypertensive treatment with propranolol who underwent surgery for intra... | [
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PMID:28631 | Accuracy and reproducibility of arterial blood-gas and pH measurements. | In 30 patients blood samples were taken from both radial arteries and analysed for PCO2, PO2 and pH. The influence of sampling technique on the accuracy of blood-gas analysis was determined. The 95% confidence limits for PCO2 measurements were +/-0.32 kPa (2.4 mmHg), and for PO2 measurements were +/-1.16 kPa (8.8 mmHg)... | Accuracy and reproducibility of arterial blood-gas and pH measurements. In 30 patients blood samples were taken from both radial arteries and analysed for PCO2, PO2 and pH. The influence of sampling technique on the accuracy of blood-gas analysis was determined. The 95% confidence limits for PCO2 measurements were +/-0... | [
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PMID:28632 | Porphyrin biosynthesis. Immobilized enzymes and ligands. VII. Studies on bovine liver porphobilinogenase. | Bovine liver porphobilinogenase (PBGase) has been covalently attached to Sepharose, and some of their properties have been studied. The optimal conditions for binding have been determined. The water-insoluble PBGase retained a high percentage of the activity of the soluble enzyme; the coupling yield was also high. Seph... | Porphyrin biosynthesis. Immobilized enzymes and ligands. VII. Studies on bovine liver porphobilinogenase. Bovine liver porphobilinogenase (PBGase) has been covalently attached to Sepharose, and some of their properties have been studied. The optimal conditions for binding have been determined. The water-insoluble PBGas... | [
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PMID:28633 | Dependence of starch synthase activity from maize leaves on light, pH and redox state. | The starch synthase activity of bundle sheath cells of maize leaves is very low in darkened plants and increases on illumination. In order to find an explanation of these facts we subjected leaf strips, isolated bundle sheath cells and enzymic preparations to pH-changes and to oxidizing or reducing substances. We found... | Dependence of starch synthase activity from maize leaves on light, pH and redox state. The starch synthase activity of bundle sheath cells of maize leaves is very low in darkened plants and increases on illumination. In order to find an explanation of these facts we subjected leaf strips, isolated bundle sheath cells a... | [
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PMID:28634 | Correction of severe metabolic acidosis: a physiological approach. | 1 - Five patients with severe metabolic acidosis secondary to methanol poisoning were studied before and after receiving 6.7 to 10 mEq NaHCO3/kg body weight. 2 - Two thirds of the infused HCO3- left the extracellular space and, since its apparent volume of distribution was much larger than under normal conditions, it l... | Correction of severe metabolic acidosis: a physiological approach. 1 - Five patients with severe metabolic acidosis secondary to methanol poisoning were studied before and after receiving 6.7 to 10 mEq NaHCO3/kg body weight. 2 - Two thirds of the infused HCO3- left the extracellular space and, since its apparent volume... | [
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PMID:28635 | Effects of ethylephrine on the rat atrial pacemaker. | Ethylephrine, assayed in isolated rat atria, as a dose-chronotropic response curve showed a typical bell-dome shape of the sympathomimetic amines. Yet, on the same basis, it was less powerful than epinephrine, norepinephrine or isoproterenol. Pretreatment with reserpine provoked supersensitivity and increase in the max... | Effects of ethylephrine on the rat atrial pacemaker. Ethylephrine, assayed in isolated rat atria, as a dose-chronotropic response curve showed a typical bell-dome shape of the sympathomimetic amines. Yet, on the same basis, it was less powerful than epinephrine, norepinephrine or isoproterenol. Pretreatment with reserp... | [
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PMID:28636 | [Effects of emetine and ipecacuana on dopamine central mechanisms. A pilot study]. | The lack of any rotational behaviour in unilaterally dopamine lesioned animals after ipecacuana or emetine is a strong indication that these substances lack dopamine receptor stimulating properties when administered systematically. Our results thus support those of Lal et al. (1972). Our results do not allow any conclu... | [Effects of emetine and ipecacuana on dopamine central mechanisms. A pilot study]. The lack of any rotational behaviour in unilaterally dopamine lesioned animals after ipecacuana or emetine is a strong indication that these substances lack dopamine receptor stimulating properties when administered systematically. Our r... | [
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PMID:28650 | Salazopyrin in rheumatoid arthritis. | After a 12-week preliminary period of observation 32 patients with consistently active rheumatoid arthritis (RA) were treated for up to 22 weeks with salazopyrin. Seven patients could not tolerate the drug. The remaining 25 patients had a marked improvement in subjective clinical state and significant falls in serum C-... | Salazopyrin in rheumatoid arthritis. After a 12-week preliminary period of observation 32 patients with consistently active rheumatoid arthritis (RA) were treated for up to 22 weeks with salazopyrin. Seven patients could not tolerate the drug. The remaining 25 patients had a marked improvement in subjective clinical st... | [
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PMID:28651 | [Seroepidemiological investigations in domestic ruminants from Egypt, Somalia and Jordan for the demonstration of complement fixing antibodies against Rickettsia and Chlamydia (author's transl)]. | 1450 random serum samples of domestic ruminants from Egypt, Somalia and Jordan were investigated for complement fixing antibodies against Rickettsia and Chlamydia. Between 1.5 and 3.4% of the samples from the animals investigated had antibodies against the RMSF-group of Rickettsia, with exception of the sera from Somal... | [Seroepidemiological investigations in domestic ruminants from Egypt, Somalia and Jordan for the demonstration of complement fixing antibodies against Rickettsia and Chlamydia (author's transl)]. 1450 random serum samples of domestic ruminants from Egypt, Somalia and Jordan were investigated for complement fixing antib... | [
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PMID:28652 | Concanavalin a receptors on the cell membrane of Trypanosoma cruzi. | Epimastigotes and trypomastigotes of T. cruzi obtained from acellular culture as well as bloodstream trypomastigotes agglutinate with concanavalin A (Con A). Con A-binding sites were also localized on the cell membrane by using the Con A-horseradish peroxidase-diaminobenzidine method. Passage of epimastigotes and trypo... | Concanavalin a receptors on the cell membrane of Trypanosoma cruzi. Epimastigotes and trypomastigotes of T. cruzi obtained from acellular culture as well as bloodstream trypomastigotes agglutinate with concanavalin A (Con A). Con A-binding sites were also localized on the cell membrane by using the Con A-horseradish pe... | [
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PMID:28653 | Electron microscopic studies on the development of kinetes of Theileria parva Theiler, 1904 in the gut of the vector ticks Rhipicephalus appendiculatus Neumann, 1901. | The development of motile stages, called kinetes, from a stationary stage (regarded as zygote) has been followed in Theileria parva by means of electron miscroscopy. This process started after moult of the tick nymphs which had sucked on highly infected calves, i.e. about 20 days after repletion (a.r.) of the ticks. Th... | Electron microscopic studies on the development of kinetes of Theileria parva Theiler, 1904 in the gut of the vector ticks Rhipicephalus appendiculatus Neumann, 1901. The development of motile stages, called kinetes, from a stationary stage (regarded as zygote) has been followed in Theileria parva by means of electron ... | [
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PMID:28654 | Studies on Dipetalonema viteae (Filarioidea) I. Microfilaraemia in hamsters in relation to worm burden and humoral immune response. | The course of a primary infection with Dipetalonema viteae was studied in one randomly bred and in one inbred strain of hamster. Worm recovery and the duration and intensity of the microfilaraemia were analyzed and related to the humoral immune response of the host by using the indirect immunofluorescent antibody test ... | Studies on Dipetalonema viteae (Filarioidea) I. Microfilaraemia in hamsters in relation to worm burden and humoral immune response. The course of a primary infection with Dipetalonema viteae was studied in one randomly bred and in one inbred strain of hamster. Worm recovery and the duration and intensity of the microfi... | [
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PMID:28655 | Studies on Dipetalonema vitae (Filarioidea). II. Antibody dependent adhesion of peritoneal exudate cells to microfilariae in vitro. | Peritoneal exudate cells from normal uninfected hamsters adhered in vitro to microfilariae in the presence of 19S antibody fractions from hamsters which had suppressed or were going to suppress their microfilaremia. The adhering cells were predominantly mononuclear, although eosinophils were occasionally found. Experim... | Studies on Dipetalonema vitae (Filarioidea). II. Antibody dependent adhesion of peritoneal exudate cells to microfilariae in vitro. Peritoneal exudate cells from normal uninfected hamsters adhered in vitro to microfilariae in the presence of 19S antibody fractions from hamsters which had suppressed or were going to sup... | [
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PMID:28656 | [A contribution to the biology of Dicrocoelium hospes Looss, 1907 (Trematoda, Dicrocoeliidae)]. | In this study, carried out in the Ivory Coast, Dicrocoelium hospes Looss, 1907 was shown for the first time to be a parasite of cattle and it was also detected in sheep by the presence of ova in the faeces. Up to 50% of the sheep in some flocks were found to shed eggs. The adults, sporocysts, "slime balls" and cercaria... | [A contribution to the biology of Dicrocoelium hospes Looss, 1907 (Trematoda, Dicrocoeliidae)]. In this study, carried out in the Ivory Coast, Dicrocoelium hospes Looss, 1907 was shown for the first time to be a parasite of cattle and it was also detected in sheep by the presence of ova in the faeces. Up to 50% of the ... | [
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PMID:28657 | Leukokinetic studies in Mediterranean kala azar. | Two patients with acute Kala Azar were studied with DF32P (diisopropylfluorophosphate) and three patients with 51Cr (chromate) in an attempt to delineate the mechanism producing neutropenia in this disease. The granulocyte life span was found to be reduced in all the patients with exception of one who was studied durin... | Leukokinetic studies in Mediterranean kala azar. Two patients with acute Kala Azar were studied with DF32P (diisopropylfluorophosphate) and three patients with 51Cr (chromate) in an attempt to delineate the mechanism producing neutropenia in this disease. The granulocyte life span was found to be reduced in all the pat... | [
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PMID:28661 | Non-invasive assessment of left internal mammary-coronary bypass patency using the external Doppler probe. | Non-directional blood velocity of left internal mammary bypass grafts was non-invasively studied with the Doppler ultrasonic probe. Thirteen of 14 subjects had angiographic evidence of bypass graft patency and their Doppler signals demonstrated high amplitude phasic blood velocities. A single patient with proximal left... | Non-invasive assessment of left internal mammary-coronary bypass patency using the external Doppler probe. Non-directional blood velocity of left internal mammary bypass grafts was non-invasively studied with the Doppler ultrasonic probe. Thirteen of 14 subjects had angiographic evidence of bypass graft patency and the... | [
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PMID:28664 | Carbohydrate metabolism in renal failure. | Hyperglycemia and impaired glucose tolerance are well known phenomena occurring in patients with renal failure. In contrast to true diabetic subjects, an elevated ratio of insulin to glucose during the glucose tolerance test is consistently observed indicating a peripheral insulin insensitivity. Among the possible reas... | Carbohydrate metabolism in renal failure. Hyperglycemia and impaired glucose tolerance are well known phenomena occurring in patients with renal failure. In contrast to true diabetic subjects, an elevated ratio of insulin to glucose during the glucose tolerance test is consistently observed indicating a peripheral insu... | [
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PMID:28665 | The role of the kidney in the removal of ketone bodies under different acid-base status of the rat. | Arterial blood concentrations of ketone bodies, pyruvate, lactate, citrate, and oxoglutarate were measured in normal and in nephrectomized rats. The rate of removal from the circulation of an infused acetoacetate load has been studied in both groups of animals. Blood oxoglutarate and ketone bodies remained unchanged in... | The role of the kidney in the removal of ketone bodies under different acid-base status of the rat. Arterial blood concentrations of ketone bodies, pyruvate, lactate, citrate, and oxoglutarate were measured in normal and in nephrectomized rats. The rate of removal from the circulation of an infused acetoacetate load ha... | [
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