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PMID:10226 | Effect of colchicine and vinblastine on crayfish neuromuscular junction. | 1. The effect of the microtubule disrupting agents colchicine and vinblastine was studied on crayfish excitatory neuromuscular transmission. 2. Colchicine, in concentrations of 1-3 mM, brought about a decrease in the amplitudes of intracellularly recorded excitatory junctional potentials (ejps). Vinblastine, in concent... | Effect of colchicine and vinblastine on crayfish neuromuscular junction. 1. The effect of the microtubule disrupting agents colchicine and vinblastine was studied on crayfish excitatory neuromuscular transmission. 2. Colchicine, in concentrations of 1-3 mM, brought about a decrease in the amplitudes of intracellularly ... | [
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PMID:10227 | Accumulation of chlorporomazine by subcellular fractions of rat brain. | 1. The study of the in vitro accumulation of [3H] chlorpromazine that a state of rapid equilibrium was reached for subcellular particles from cortex, midbrain and hindbrain of rats. 2. This accumulation was not saturable by increasing the concentration of chlorpromazine, and the relationship between accumulation and co... | Accumulation of chlorporomazine by subcellular fractions of rat brain. 1. The study of the in vitro accumulation of [3H] chlorpromazine that a state of rapid equilibrium was reached for subcellular particles from cortex, midbrain and hindbrain of rats. 2. This accumulation was not saturable by increasing the concentrat... | [
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PMID:10229 | [Effect of mutagenic metabolic activation of N-nitrosomorpholine on microorganisms]. | Almost similar sensitivity is demonstrated of different methods of studying mutagenic metabolic activation of N-nitrosomorpholine (NM) in Salmonella typhimurium TA 1950 (host-mediated assay and the system of metabolic activation with rat liver homogenate). The role of correlation of certain ingredients of NM metabolic ... | [Effect of mutagenic metabolic activation of N-nitrosomorpholine on microorganisms]. Almost similar sensitivity is demonstrated of different methods of studying mutagenic metabolic activation of N-nitrosomorpholine (NM) in Salmonella typhimurium TA 1950 (host-mediated assay and the system of metabolic activation with r... | [
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PMID:10230 | Mechanisms of arrhythmias in chronic obstructive lung disease. | Because of the close anatomic and physiologic relationship between the heart and lungs, patients with chronic obstructive lung disease are at special risk of arrhythmias. Effective therapy hinges on identifying the mechanisms of the arrhythmias--hemodynamic, metabolic, or drug-induced. Impulsive use of antiarrhythmic a... | Mechanisms of arrhythmias in chronic obstructive lung disease. Because of the close anatomic and physiologic relationship between the heart and lungs, patients with chronic obstructive lung disease are at special risk of arrhythmias. Effective therapy hinges on identifying the mechanisms of the arrhythmias--hemodynamic... | [
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PMID:10233 | Social work training of new health professionals. | The Child Health Associate program provides a model for using social workers in the training of new health professionals. Administratively, social workers have contributed to curriculum development in the behavioral sciences. They have influenced decisions regarding student selection and have developed and implemented ... | Social work training of new health professionals. The Child Health Associate program provides a model for using social workers in the training of new health professionals. Administratively, social workers have contributed to curriculum development in the behavioral sciences. They have influenced decisions regarding stu... | [
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PMID:10234 | [Experimental study on prediction of drug toxicity. Drug-induced hemolysis and lysosomes lysis in vitro]. | The effect of drugs on isolated rat liver lysosomes, erythrocytes and some erythrocyte enzymes was studied in vitro. Many tranquilizers, antihistaminics and antidepressants, which are known to have the greatest number of adverse reactions in clinical use, had a lytic effect on the particle membranes at concentrations a... | [Experimental study on prediction of drug toxicity. Drug-induced hemolysis and lysosomes lysis in vitro]. The effect of drugs on isolated rat liver lysosomes, erythrocytes and some erythrocyte enzymes was studied in vitro. Many tranquilizers, antihistaminics and antidepressants, which are known to have the greatest num... | [
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PMID:10235 | [Action mechanisms of the contracting drugs, K, acetylcholine, histamine and Ba and of the antispasmodics, isoproterenol and papaverine in the isolated guinea pig ileum, particularly in relation to Ca]. | Shapes of the contractions induced by K, acetylcholine (AHc), histamine and Ba consisted of the phasic contraction (PC) and the subsequent tonic contraction (TC). PCs by K, ACh and histamine are initiated by the release and the passive influx of Ca, whereas that by Ba is only initiated by the release of Ca. TCs by K, A... | [Action mechanisms of the contracting drugs, K, acetylcholine, histamine and Ba and of the antispasmodics, isoproterenol and papaverine in the isolated guinea pig ileum, particularly in relation to Ca]. Shapes of the contractions induced by K, acetylcholine (AHc), histamine and Ba consisted of the phasic contraction (P... | [
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PMID:10236 | [Action mechanism of dibenamine on the tonus and inhibition of drug-induced contraction of the isolated guinea pig ileum, with special reference to its relationship to Ca]. | Dibenamine (DB) produced contraction due to influx and release of Ca in normal medium, whereas it produced relaxation of the K-induced contraction due to depression of the activity of the muscle cell membrane. DB inhibited active influx, passive influx and release of Ca induced by ACh in this order as the concentration... | [Action mechanism of dibenamine on the tonus and inhibition of drug-induced contraction of the isolated guinea pig ileum, with special reference to its relationship to Ca]. Dibenamine (DB) produced contraction due to influx and release of Ca in normal medium, whereas it produced relaxation of the K-induced contraction ... | [
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PMID:10239 | Effect of hypophysectomy and insulin on lipogenesis in cockerels. | Hypophysectomy increases hepatic lipogenesis in cockerels. In an attempt to find the possible hormonal mechanism for this we have examined the effects of hypophysectomy, insulin and pituitary homogenates on hepatic lipogenesis. Insulin (5 U/kg) injected intravenously, simultaneously with glucose-14C tracer, increased t... | Effect of hypophysectomy and insulin on lipogenesis in cockerels. Hypophysectomy increases hepatic lipogenesis in cockerels. In an attempt to find the possible hormonal mechanism for this we have examined the effects of hypophysectomy, insulin and pituitary homogenates on hepatic lipogenesis. Insulin (5 U/kg) injected ... | [
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PMID:10240 | Effects of lithium on inducible enzymes of rat liver. | Chronic lithium administration to female rats results in elevation of serum corticoids, lowering of serum glucose and altered induction of liver enzymes. The cortisol induction of tyrosine transaminase is increased selectively over that of tryptophan oxygenase. The glucose induction of glucokinase following a fast is i... | Effects of lithium on inducible enzymes of rat liver. Chronic lithium administration to female rats results in elevation of serum corticoids, lowering of serum glucose and altered induction of liver enzymes. The cortisol induction of tyrosine transaminase is increased selectively over that of tryptophan oxygenase. The ... | [
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PMID:10242 | [Metabolism of nicotinic acid in plant cell suspension cultures: II; Isolation, characterization and enzymology of nicotinic acid N-alpha-arabinoside (author's transl)]. | A very hydrophilic compound was isolated from parsley cell suspension cultures in high yield after application of nicotinic acid. Using chemical, chromatographic and spectroscopic procedures the structure of this new plant constituent has been elucidated as nicotinic acid N-alpha-L-arabinopyranoside. This structure has... | [Metabolism of nicotinic acid in plant cell suspension cultures: II; Isolation, characterization and enzymology of nicotinic acid N-alpha-arabinoside (author's transl)]. A very hydrophilic compound was isolated from parsley cell suspension cultures in high yield after application of nicotinic acid. Using chemical, chro... | [
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PMID:10243 | Chemical modification of two tryptophan residues abolishes the catalytic activity of aminoacylase. | 1) The reaction of 1 H-diazotetrazole and N-bromosuccinimide with aminoacylase was studied under different conditions. A tenfold molar excess of 1 H-diazotetrazole (2 X 10(-4) M) at pH 5.5 abolishes the catalytic activity of the enzyme while modifying only two tryptophan residues. No other amino acid reacted under thes... | Chemical modification of two tryptophan residues abolishes the catalytic activity of aminoacylase. 1) The reaction of 1 H-diazotetrazole and N-bromosuccinimide with aminoacylase was studied under different conditions. A tenfold molar excess of 1 H-diazotetrazole (2 X 10(-4) M) at pH 5.5 abolishes the catalytic activity... | [
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PMID:10244 | Studies on ribonucleic acid metabolism using nuclear columns. Release of rapidly labeled RNA from rat liver nuclei. | A method is described to study the effect of successively changing incubation conditions on the release of rapidly labeled RNA from isolated nuclei. Nuclear columns containing immobilized rat liver nuclei isolated after in vivo application of labeled orotic acid are perfused with different non-radioactive media. Within... | Studies on ribonucleic acid metabolism using nuclear columns. Release of rapidly labeled RNA from rat liver nuclei. A method is described to study the effect of successively changing incubation conditions on the release of rapidly labeled RNA from isolated nuclei. Nuclear columns containing immobilized rat liver nuclei... | [
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PMID:10245 | [Hydroxylation of testosterone and 5alpha-dihydrotestosterone--isolation of 2alpha-hydroxytestosterone (author's transl)]. | The hydroxylation at C-2 of testosterone and 5alpha-dihydrotestosterone is measured by isolation of HTO after incubating "metabolically labile" tritium labeled steroids with the enzymes. After hydroxylation of testosterone in rat liver 2alpha-hydroxytestosterone was isolated and identified by gaschromatography and mass... | [Hydroxylation of testosterone and 5alpha-dihydrotestosterone--isolation of 2alpha-hydroxytestosterone (author's transl)]. The hydroxylation at C-2 of testosterone and 5alpha-dihydrotestosterone is measured by isolation of HTO after incubating "metabolically labile" tritium labeled steroids with the enzymes. After hydr... | [
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PMID:10246 | The activator of cerebroside sulphatase. Lysosomal localization. | 1) An activator protein necessary for the enzymic hydrolysis of cerebroside sulphate could be partially purified from unfractionated rat liver. This activator, which is similar to that of human origin, proved to be a heat-stable, non-dialyzable, low molecular weight protein with an isoelectric point of 4.1. Its activit... | The activator of cerebroside sulphatase. Lysosomal localization. 1) An activator protein necessary for the enzymic hydrolysis of cerebroside sulphate could be partially purified from unfractionated rat liver. This activator, which is similar to that of human origin, proved to be a heat-stable, non-dialyzable, low molec... | [
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PMID:10259 | Blastogenic response of human lymphocytes to oral bacterial antigens: comparison of individuals with periodontal disease to normal and edentulous subjects. | Cell-mediated immunity in humans to antigens derived from oral plaque bacteria was investigated by using the lymphocyte blastogenesis assay. Subjects with varying severities of periodontal disease including normal, gingivitis, periodontitis, and edentulous were compared. Mononuclear leukocytes were separated from perip... | Blastogenic response of human lymphocytes to oral bacterial antigens: comparison of individuals with periodontal disease to normal and edentulous subjects. Cell-mediated immunity in humans to antigens derived from oral plaque bacteria was investigated by using the lymphocyte blastogenesis assay. Subjects with varying s... | [
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PMID:10260 | Prevention of benzo(a)pyrene-induced mutagenicity by homogeneous epoxide hydratase. | Benzo(a)pyrene and benz(a) anthrancene which, in contrast to the K-region epoxides benzo(a)pyrene 4,5-oxide and benz(a)anthracene 5,6-oxide, are not mutagenic to Salmonella typhimurium TA 1537 in the absence of mammalian enzyme preparations, were activated by liver microsomes from C3H mice, which had not received any p... | Prevention of benzo(a)pyrene-induced mutagenicity by homogeneous epoxide hydratase. Benzo(a)pyrene and benz(a) anthrancene which, in contrast to the K-region epoxides benzo(a)pyrene 4,5-oxide and benz(a)anthracene 5,6-oxide, are not mutagenic to Salmonella typhimurium TA 1537 in the absence of mammalian enzyme preparat... | [
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PMID:10261 | The intraocular pressure response of conscious rabbits to clonidine. | A study has been made of the time courses of the pupillary and intraocular pressure responses of conscious rabbits to clonidine administered either topically or intravenously. Topical unilateral application of clonidine caused transient pupil dilatation and a biphasic intraocular pressure response; an initial hypertens... | The intraocular pressure response of conscious rabbits to clonidine. A study has been made of the time courses of the pupillary and intraocular pressure responses of conscious rabbits to clonidine administered either topically or intravenously. Topical unilateral application of clonidine caused transient pupil dilatati... | [
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PMID:10262 | The effect of miotics on the intraocular pressure of conscious owl monkeys. | The intraocular pressure of conscious, unsedated owl monkeys (Aotus trivirgatus) was measured with an applanation tonometer. Untreated eyes of the conscious animals were found to have higher values than those reported for owl monkeys anesthetized with pentobarbitone. Locally applied pilocarpine, carbachol, and oxotremo... | The effect of miotics on the intraocular pressure of conscious owl monkeys. The intraocular pressure of conscious, unsedated owl monkeys (Aotus trivirgatus) was measured with an applanation tonometer. Untreated eyes of the conscious animals were found to have higher values than those reported for owl monkeys anesthetiz... | [
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PMID:10263 | Interaction of Listeria monocytogenes and influenza in an animal model. | This study was designed to investigate the effects of viruses in the pathogenesis of Listeria monocytogenes. The organisms used in this study were: Listeria monocytogenes Type 1 isolated from a local fatal case; Mouse adapted influenza A/PR8/34 (HONI); Streptococcus pneumoniae Group B (U.M. Med. Ctr.) and poliovirus Ty... | Interaction of Listeria monocytogenes and influenza in an animal model. This study was designed to investigate the effects of viruses in the pathogenesis of Listeria monocytogenes. The organisms used in this study were: Listeria monocytogenes Type 1 isolated from a local fatal case; Mouse adapted influenza A/PR8/34 (HO... | [
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PMID:10266 | [The symptomatic treatment of seasonal allergic rhinitis (author's transl)]. | The aetiology, pathophysiology and symptomatology of seasonal rhinitis are briefly presented. Symptomatic therapy with antihistamines, nasal decongestants and local and systemic corticosteroids is critically discussed. The results of a trial with Disodium cromoglycate are reported. This is shown to be a valuable drug i... | [The symptomatic treatment of seasonal allergic rhinitis (author's transl)]. The aetiology, pathophysiology and symptomatology of seasonal rhinitis are briefly presented. Symptomatic therapy with antihistamines, nasal decongestants and local and systemic corticosteroids is critically discussed. The results of a trial w... | [
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PMID:10267 | Male pseudohermaphroditism, cryptorchism, and Sertoli cell neoplasia in three miniature Schnauzers. | A syndrome of male pseudohermaphroditism, cryptorchidism, and testicular neoplasia was diagnosed in 3 Miniature Schnauzers. The dogs had clinical signs of hyperestrogenism and were either unilateral or bilateral cryptorchids. At surgery, it was discovered that the dogs were male pseudohermaphrodites, having intra-abdom... | Male pseudohermaphroditism, cryptorchism, and Sertoli cell neoplasia in three miniature Schnauzers. A syndrome of male pseudohermaphroditism, cryptorchidism, and testicular neoplasia was diagnosed in 3 Miniature Schnauzers. The dogs had clinical signs of hyperestrogenism and were either unilateral or bilateral cryptorc... | [
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PMID:10268 | Observations on immobilization of Père David's deer. | Etorphine and xylazine were found to be a safe and reliable drug combination for the immobilization of Père David's deer, whether excited or unexcited. Excited deer had a longer preimmobilization period, when compared with unexcited deer at comparable dosages. Generally, the acid-base status of Père David's deer during... | Observations on immobilization of Père David's deer. Etorphine and xylazine were found to be a safe and reliable drug combination for the immobilization of Père David's deer, whether excited or unexcited. Excited deer had a longer preimmobilization period, when compared with unexcited deer at comparable dosages. Genera... | [
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PMID:10269 | The proliferation of transplanted haematopoietic cells derived from bone marrow and fetal liver. | The proliferation of transplanted murine haematopoietic cells, derived from the femoral bone marrow of young adults and from the liver on the sixteenth day of gestation, has been compared under standardized conditions. Suspensions of bone marrow cells contained 9-6+/-0-9 CFU per 10(5) cells (sm) and suspensions of feta... | The proliferation of transplanted haematopoietic cells derived from bone marrow and fetal liver. The proliferation of transplanted murine haematopoietic cells, derived from the femoral bone marrow of young adults and from the liver on the sixteenth day of gestation, has been compared under standardized conditions. Susp... | [
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PMID:10273 | Metabolism of DL-(+/-)-phenylalanine by Aspergillus niger. | A fungus capable of degrading DL-phenylalanine was isolated from the soil and identified as Aspergillus niger. It was found to metabolize DL-phenylalanine by a new pathway involving 4-hydroxymandelic acid. D-Amino acid oxidase and L-phenylalanine: 2-oxoglutaric acid aminotransferase initiated the degradation of D- and ... | Metabolism of DL-(+/-)-phenylalanine by Aspergillus niger. A fungus capable of degrading DL-phenylalanine was isolated from the soil and identified as Aspergillus niger. It was found to metabolize DL-phenylalanine by a new pathway involving 4-hydroxymandelic acid. D-Amino acid oxidase and L-phenylalanine: 2-oxoglutaric... | [
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PMID:10274 | Microbial oxidation of methane and methanol: crystallization and properties of methanol dehydrogenase from Methylosinus sporium. | Obligate methylotrophs are divisible into two types on the basis of ultrastructural biochemical characteristics. Both groups possess a soluble phenazine methosulfate (PMS)-dependent methanol dehydrogenase. In addition, particulate PMS-dependent methanol dehydrogenase and PMS-independent methanol oxidase have been found... | Microbial oxidation of methane and methanol: crystallization and properties of methanol dehydrogenase from Methylosinus sporium. Obligate methylotrophs are divisible into two types on the basis of ultrastructural biochemical characteristics. Both groups possess a soluble phenazine methosulfate (PMS)-dependent methanol ... | [
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... |
PMID:10275 | Mutant strains (nit) of Salmonella typhimurium with a pleiotropic defect in nitrogen metabolism. | We have isolated mutant strains (nit) of Salmonella typhimurium that are defective in nitrogen metabolism. They have a reduced ability to use a variety of compounds including glutamate, proline, arginine, N-acetyl-glucosamine, alanine, and adenosine as sole nitrogen source. In addition, although they grow normally on h... | Mutant strains (nit) of Salmonella typhimurium with a pleiotropic defect in nitrogen metabolism. We have isolated mutant strains (nit) of Salmonella typhimurium that are defective in nitrogen metabolism. They have a reduced ability to use a variety of compounds including glutamate, proline, arginine, N-acetyl-glucosami... | [
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PMID:10276 | Stable, inducible thermoacidophilic alpha-amylase from Bacillus acidocaldarius. | Bacillus acidocaldarius Agnano 101 produces an inducible thermoacidophilic alpha-amylase. The enzyme production occurs during the stationary phase of growth in the presence of compounds with alpha-1,4-glucosidic linkages. The enzymatic activity is both present in the culture medium and associated with the cells; the en... | Stable, inducible thermoacidophilic alpha-amylase from Bacillus acidocaldarius. Bacillus acidocaldarius Agnano 101 produces an inducible thermoacidophilic alpha-amylase. The enzyme production occurs during the stationary phase of growth in the presence of compounds with alpha-1,4-glucosidic linkages. The enzymatic acti... | [
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PMID:10277 | Size and transforming activity of deoxyribonucleic acid in Diplococcus pneumoniae during thymidine starvation. | The transforming activity and the molecular structure of DNA from cells of Diplococcus pneumoniae during thymidine starvation have been analyzed and the effects of thymidine starvation have been compared with the effects of single-strand breaks produced by deoxyribonucleases in DNA of unstarved cells. The decrease in t... | Size and transforming activity of deoxyribonucleic acid in Diplococcus pneumoniae during thymidine starvation. The transforming activity and the molecular structure of DNA from cells of Diplococcus pneumoniae during thymidine starvation have been analyzed and the effects of thymidine starvation have been compared with ... | [
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... |
PMID:10278 | Carbon and ammonia metabolism of Spirillum lipoferum. | Intact cells and extracts from Spirillum lipoferum rapidly oxidized malate, succinate, lactate, and pyruvate. Glucose, galactose, fructose, acetate, and citrate did not increase the rate of O2 uptake by cells above the endogenous rate. Cells grown on NH+/4 oxidized the various substrates at about the same rate as did c... | Carbon and ammonia metabolism of Spirillum lipoferum. Intact cells and extracts from Spirillum lipoferum rapidly oxidized malate, succinate, lactate, and pyruvate. Glucose, galactose, fructose, acetate, and citrate did not increase the rate of O2 uptake by cells above the endogenous rate. Cells grown on NH+/4 oxidized ... | [
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PMID:10279 | Photosystem II regulation of macromolecule synthesis in the blue-green alga Aphanocapsa 6714. | Polymers synthesized by heterotrophically growing (glucose as carbon source) cultures of Aphanocapsa 6714 were compared with polymers synthesized in photosynthetically grown cultures. Loss of photosystem II by dark incubation, or inhibition of light-grown cells with the photosystem II-specific inhibitor dichlorophenyl... | Photosystem II regulation of macromolecule synthesis in the blue-green alga Aphanocapsa 6714. Polymers synthesized by heterotrophically growing (glucose as carbon source) cultures of Aphanocapsa 6714 were compared with polymers synthesized in photosynthetically grown cultures. Loss of photosystem II by dark incubation... | [
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PMID:10280 | Subunits of the alkaline phosphatase of Bacillus licheniformis: chemical, physicochemical, and dissociation studies. | The alkaline phosphatase (orthophosphoric monoester phosphydrolase, EC 3.1.3.1) of Bacillus licheniformis MC14 was studied in an attempt to determine the number of subunits contained in the 120,000-molecular-weight native enzyme. Two moles of arginine was liberated per mole of native enzyme by carboxypeptidases A and B... | Subunits of the alkaline phosphatase of Bacillus licheniformis: chemical, physicochemical, and dissociation studies. The alkaline phosphatase (orthophosphoric monoester phosphydrolase, EC 3.1.3.1) of Bacillus licheniformis MC14 was studied in an attempt to determine the number of subunits contained in the 120,000-molec... | [
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PMID:10281 | Inorganic nitrogen assimilation by the photosynthetic bacterium Rhodopseudomonas capsulata. | The photosynthetic bacterium Rhodopseudomonas capsulata lacks glutamate dehydrogenase and normally uses the glutamine synthetase/glutamate synthase sequence of reactions for assimilation of N2 and ammonia. The glutamine synthetase in cell-free extracts of the organism is completely sedimented by centrifugation at 140,0... | Inorganic nitrogen assimilation by the photosynthetic bacterium Rhodopseudomonas capsulata. The photosynthetic bacterium Rhodopseudomonas capsulata lacks glutamate dehydrogenase and normally uses the glutamine synthetase/glutamate synthase sequence of reactions for assimilation of N2 and ammonia. The glutamine syntheta... | [
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PMID:10282 | Interactions on 3-deoxy and 6-deoxy derivatives of N-acetyl-D-glucosamine with hen lysozyme. | The interactions of deoxy derivatives of GlcNAc, 6-deoxy-GlcNAc, and 3-deoxy-GlcNAc with hen egg-white lysozyme [EC 3.2.1.17] were studied at various pH's by measuring the changes in the circular dichroic (CD) band at 295 nm. It was shown that 6-deoxy-GlcNAc and 3-deoxy-GlcNAc bind at subsite C of lysozyme and compete ... | Interactions on 3-deoxy and 6-deoxy derivatives of N-acetyl-D-glucosamine with hen lysozyme. The interactions of deoxy derivatives of GlcNAc, 6-deoxy-GlcNAc, and 3-deoxy-GlcNAc with hen egg-white lysozyme [EC 3.2.1.17] were studied at various pH's by measuring the changes in the circular dichroic (CD) band at 295 nm. I... | [
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PMID:10283 | Interactions of alpha- and beta-N-acetyl-D-glucosamines with hen and turkey lysozymes. | The binding constants of alpha- and beta-GlcNAc to hen and turkey lysozymes [EC 3.2.1.17] were determined at various pH's using the method proposed by Ikeda and Hamaguchi (1975) J. Biochem. 77, 1-16). The pH dependence of the binding of beta-GlcNAc to hen lysozyme was essentially the same as that for turkey lysozyme. T... | Interactions of alpha- and beta-N-acetyl-D-glucosamines with hen and turkey lysozymes. The binding constants of alpha- and beta-GlcNAc to hen and turkey lysozymes [EC 3.2.1.17] were determined at various pH's using the method proposed by Ikeda and Hamaguchi (1975) J. Biochem. 77, 1-16). The pH dependence of the binding... | [
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... |
PMID:10284 | Binding of substrate analogs to hen egg-white lysozyme with an ester linkage between Glu 35 and Trp 108. | The interactions of the substrate analogs beta-methyl-GlcNAc, (GlcNAc)2, and (GlcNAc)3 with hen egg-white lysozyme [EC 3.2.1.17] in which an ester linkage had been formed between Glu 35 and Trp 108 (108 ester lysozyme), were studied by the circular dichroic and fluorescence techniques, and were compared with those for ... | Binding of substrate analogs to hen egg-white lysozyme with an ester linkage between Glu 35 and Trp 108. The interactions of the substrate analogs beta-methyl-GlcNAc, (GlcNAc)2, and (GlcNAc)3 with hen egg-white lysozyme [EC 3.2.1.17] in which an ester linkage had been formed between Glu 35 and Trp 108 (108 ester lysozy... | [
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PMID:10285 | Near-UV circular dichroism of trypsin inhibitor of adzuki beans attributable to disulfide groups. | The trypsin inhibitor of adzuki (Phaseolus angularis) beans shows a CD spectrum with a negative extremum at 280 nm and a positive shoulder around 245 nm. Since the inhibitor lacks tryptophan and tyrosine, the observed CD spectrum can be attributed to the six disulfide groups in the molecule. The CD features completely ... | Near-UV circular dichroism of trypsin inhibitor of adzuki beans attributable to disulfide groups. The trypsin inhibitor of adzuki (Phaseolus angularis) beans shows a CD spectrum with a negative extremum at 280 nm and a positive shoulder around 245 nm. Since the inhibitor lacks tryptophan and tyrosine, the observed CD s... | [
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PMID:10286 | Interaction of diiodo-L-tyrosine and triiodophenol with bovine serum albumin. Circular dichroism and fluorescence studies. | As a model study to investigate the binding mechanism between thyroid hormones and carrier protein, the interaction of diiodo-L-tyrosine (DIT) and triiodophenol (I3phi) with bovine serum albumin (BSA) was investigated by circular dichroism (CD) and fluorescence methods. In both the DIT-BSA system and the I3phi-BSA syst... | Interaction of diiodo-L-tyrosine and triiodophenol with bovine serum albumin. Circular dichroism and fluorescence studies. As a model study to investigate the binding mechanism between thyroid hormones and carrier protein, the interaction of diiodo-L-tyrosine (DIT) and triiodophenol (I3phi) with bovine serum albumin (B... | [
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PMID:10287 | Renal angiotensin I-converting enzyme as a mixture of sialo- and asialo-enzyme, and a rapid purification method. | Angiotensin I-converting enzyme [EC 3.4.15.1] was rapidly and highly purified from a particulate fraction of hog kidney cortex with 13% yield. The procedure, which was rapid, included fractionation on DEAE-cellulose and calcium phosphate gel, chromatographies on DEAE-Sephadex A-50 and hydroxylapatite columns, and gel f... | Renal angiotensin I-converting enzyme as a mixture of sialo- and asialo-enzyme, and a rapid purification method. Angiotensin I-converting enzyme [EC 3.4.15.1] was rapidly and highly purified from a particulate fraction of hog kidney cortex with 13% yield. The procedure, which was rapid, included fractionation on DEAE-c... | [
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PMID:10288 | Some catalytic and molecular properties of threonine deaminase from Bacillus stearothermophilus. | Threonine deaminase [EC 4.2.1.16] was highly purified from Bacillus stearothermophilus. The enzyme exhibited maximum activity at 65 degrees and at pH 9.2--9.6. It was inactivated on dilution and on storage at 4 degrees, but was protected by egg albumin. The enzyme was labile at 65 degrees, but became stable in the pres... | Some catalytic and molecular properties of threonine deaminase from Bacillus stearothermophilus. Threonine deaminase [EC 4.2.1.16] was highly purified from Bacillus stearothermophilus. The enzyme exhibited maximum activity at 65 degrees and at pH 9.2--9.6. It was inactivated on dilution and on storage at 4 degrees, but... | [
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PMID:10289 | Temperature-jump studies on the interaction of benzeneboronic acid with chymotrypsinogen. | The interaction of chymotrypsinogen A with benzeneboronic acid (BBA), a transition state along inhibitor of serine proteases, was investigated by the temperature-jump method using pH indicators. It was found that l/tau is dependent on BBA concentration, in contrast to the case of the alpha-chymotrypsin [EC 3.4.21.1]-BB... | Temperature-jump studies on the interaction of benzeneboronic acid with chymotrypsinogen. The interaction of chymotrypsinogen A with benzeneboronic acid (BBA), a transition state along inhibitor of serine proteases, was investigated by the temperature-jump method using pH indicators. It was found that l/tau is dependen... | [
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PMID:10290 | The structure and function of acid proteases. V. Comparative studies on the specific inhibition of acid proteases by diazoacetyl-DL-norleucine methyl ester, 1,2-epoxy-3-(p-nitrophenoxy) propane and pepstatin. | Comparative studies have been made on the effects of diazoacetyl-DL-norleucine methyl ester (DAN), 1,2-epoxy-3-(p-nitrophenoxy)propane (EPNP) and pepstatin on acid proteases, including those from Acrocylindrium sp., Aspergillus niger, Aspergillus saitoi, Mucor pusillus, Paecilomyces varioti, Rhizopus chinensis, and Tra... | The structure and function of acid proteases. V. Comparative studies on the specific inhibition of acid proteases by diazoacetyl-DL-norleucine methyl ester, 1,2-epoxy-3-(p-nitrophenoxy) propane and pepstatin. Comparative studies have been made on the effects of diazoacetyl-DL-norleucine methyl ester (DAN), 1,2-epoxy-3-... | [
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PMID:10291 | In vitro stimulation by retinol of porcine pancreatic esterase activity toward esters of short-chain fatty acids. | 1. Retinol exerted a remarkable stimulating effect (approx. 260% increase), essentially similar to that (300%) of phytol, on the so-called esterase activity displayed by crude pancreatic lipase [EC 3.1.1.3] toward true solutions of esters, but none of the typical lipase activity toward emulsions of water-insoluble este... | In vitro stimulation by retinol of porcine pancreatic esterase activity toward esters of short-chain fatty acids. 1. Retinol exerted a remarkable stimulating effect (approx. 260% increase), essentially similar to that (300%) of phytol, on the so-called esterase activity displayed by crude pancreatic lipase [EC 3.1.1.3]... | [
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... |
PMID:10292 | Cardiac myosin from pig heart ventricle. Purification and enzymatic properties. | A method is described for the preparation of high purity myosin from the left ventricle of pig heart. The purified myosin was free from nucleic acid, actin, tropomyosin, troponin, the 150,000 molecular weight protein and other contaminants. Analyses of subunits in the purified myosin were carried out on 3.5% acrylamide... | Cardiac myosin from pig heart ventricle. Purification and enzymatic properties. A method is described for the preparation of high purity myosin from the left ventricle of pig heart. The purified myosin was free from nucleic acid, actin, tropomyosin, troponin, the 150,000 molecular weight protein and other contaminants.... | [
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0.00... |
PMID:10293 | Inability of the smallest light chain to bind to fetal fast muscle myosin. | 1. The smallest light chain of myosin, g3, was not transferred from adult HMM to fetal myosin in alkali (pH 10.5) under conditions when the light chains dissociated from myosin. 2. The g3 isolated from adult myosin did not bind to fetal myosin at either pH 7.8 or 10.5. | Inability of the smallest light chain to bind to fetal fast muscle myosin. 1. The smallest light chain of myosin, g3, was not transferred from adult HMM to fetal myosin in alkali (pH 10.5) under conditions when the light chains dissociated from myosin. 2. The g3 isolated from adult myosin did not bind to fetal myosin a... | [
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0.01423654519021511,
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-0.06345425546169281,
0.03987... |
PMID:10294 | Differences in phosphofructokinase regulation in normal and tumor rat thyroid cells. | The kinetic and molecular properties of a phosphofructokinase derived from a transplantable rat thyroid tumor lacking regulatory control on the glycolytic pathway were studied. The properties of the near-purified enzyme (specific activity 140 units/mg) were compared with those of phosphofructokinase from normal rat thy... | Differences in phosphofructokinase regulation in normal and tumor rat thyroid cells. The kinetic and molecular properties of a phosphofructokinase derived from a transplantable rat thyroid tumor lacking regulatory control on the glycolytic pathway were studied. The properties of the near-purified enzyme (specific activ... | [
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0.06343375891447067,
-0.06582275032997131,
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... |
PMID:10295 | Partial purification and characterization of a triglyceride lipase from pig adipose tissue. | A triglyceride lipase was extracted from defatted pig adipose tissue powder with dilute ammonia and purified about 230-fold by a combination of ammonium sulfate fractionation, heparin-Sepharose 4B, DEAE-cellulose, and Sephadex G-150 column chromatographies and isoelectrofocusing electrophoresis. The enzyme was distingu... | Partial purification and characterization of a triglyceride lipase from pig adipose tissue. A triglyceride lipase was extracted from defatted pig adipose tissue powder with dilute ammonia and purified about 230-fold by a combination of ammonium sulfate fractionation, heparin-Sepharose 4B, DEAE-cellulose, and Sephadex G... | [
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PMID:10296 | Compound X. An intermediate in enzymatic halogenation. | Previous studies have shown that chlorite serves as a halogenation substrate for horseradish peroxidase. In its substrate role, chlorite serves both as a halogen donor and as a source of oxidizing equivalents in the chlorination reaction. We now show that a new spectral intermediate, which we have termed Compound X, ca... | Compound X. An intermediate in enzymatic halogenation. Previous studies have shown that chlorite serves as a halogenation substrate for horseradish peroxidase. In its substrate role, chlorite serves both as a halogen donor and as a source of oxidizing equivalents in the chlorination reaction. We now show that a new spe... | [
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PMID:10297 | Studies on the regulation of chloroplast NADP-linked glyceraldehyde-3-phosphate dehydrogenase. | Chloroplast NADP-linked glyceraldehyde-3-phosphate dehydrogenase was resolved into three forms that differed in molecular weight: (a) larger than or equal to 1.5 million; (b) 600,000; and (c) less than or equal to 100,000. After preincubation with an effector (ATP, NADPH, or Pi) the activity of forms a and c was unaffe... | Studies on the regulation of chloroplast NADP-linked glyceraldehyde-3-phosphate dehydrogenase. Chloroplast NADP-linked glyceraldehyde-3-phosphate dehydrogenase was resolved into three forms that differed in molecular weight: (a) larger than or equal to 1.5 million; (b) 600,000; and (c) less than or equal to 100,000. Af... | [
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PMID:10298 | Induction of lipogenesis during differentiation in a "preadipocyte" cell line. | 3T3-L1 fibroblasts differentiate in culture into cells having adipocyte character. This transition is accompanied by a 40- to 50-fold rise in the incorporation of [14C]acetate into triglyceride. The increase in lipogenic rate is exactly parallel to a coordinate rise in the activities of the key enzymes of the fatty ac... | Induction of lipogenesis during differentiation in a "preadipocyte" cell line. 3T3-L1 fibroblasts differentiate in culture into cells having adipocyte character. This transition is accompanied by a 40- to 50-fold rise in the incorporation of [14C]acetate into triglyceride. The increase in lipogenic rate is exactly par... | [
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PMID:10299 | Enzymatic synthesis of biopterin from D-erythrodihydroneopterin triphosphate by extracts of kidneys from Syrian golden hamsters. | An enzyme system was found in either crude homogenates of dialyzed extracts of liver, kidney, lung, and brain from Syrian golden hamsters that catalyzed the synthesis of radioactive 6(L-erythro-1',2'-dihydroxypropyl)pterin (biopterin) from [U-14C]6(D-erythro-1',2',3'-trihydroxypropyl)-7,8-dihydropterin triphosphate (D-... | Enzymatic synthesis of biopterin from D-erythrodihydroneopterin triphosphate by extracts of kidneys from Syrian golden hamsters. An enzyme system was found in either crude homogenates of dialyzed extracts of liver, kidney, lung, and brain from Syrian golden hamsters that catalyzed the synthesis of radioactive 6(L-eryth... | [
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PMID:10300 | Purification and characterization of N-hydroxy-2-acetylaminofluorene sulfotransferase from rat liver. | N-Hydroxy-2-acetylaminofluorene (N-OH-2-AAF) sulfotransferase is an enzyme that catalyzes the sulfate transfer from the active sulfate, 3'-phosphoadenosine 5'-phosphosulfate (PAPS), to N-OH-2-AAF to form a highly reactive product acetylaminofluorene N-sulfate. It has been purified about 2000-fold with a yield of over 1... | Purification and characterization of N-hydroxy-2-acetylaminofluorene sulfotransferase from rat liver. N-Hydroxy-2-acetylaminofluorene (N-OH-2-AAF) sulfotransferase is an enzyme that catalyzes the sulfate transfer from the active sulfate, 3'-phosphoadenosine 5'-phosphosulfate (PAPS), to N-OH-2-AAF to form a highly react... | [
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PMID:10301 | Photochemical studies and ultraviolet sensitization of Escherichia coli thymidylate kinase by various halogenated substrate analogs. | The effect of 5-iodo-2'-deoxyuridine monophosphate (IdUMP), various 5-halogenated-5'-azido-2', 5' -dideoxyuridine derivatives, 2'-deoxy-6-azauridine (AzdUrd), and its halogenated analogs on the ultraviolet sensitization of Escherichia coli thymidylate kinase has been investigated. Only those compounds iodinated in posi... | Photochemical studies and ultraviolet sensitization of Escherichia coli thymidylate kinase by various halogenated substrate analogs. The effect of 5-iodo-2'-deoxyuridine monophosphate (IdUMP), various 5-halogenated-5'-azido-2', 5' -dideoxyuridine derivatives, 2'-deoxy-6-azauridine (AzdUrd), and its halogenated analogs ... | [
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PMID:10302 | Kinetic studies on the binding affinity of human hemoglobin for the 4th carbon monoxide molecule, L4. | L4, the affinity of hemoglobin for the 4th CO molecule, has been determined for human adult hemoglobin (HbA) as a function of pH and the presence of organic phosphates by measuring the kinetic parameters for the reaction. l'4, the rate of combination of CO with the triliganded molecule, was measured by flash photolysis... | Kinetic studies on the binding affinity of human hemoglobin for the 4th carbon monoxide molecule, L4. L4, the affinity of hemoglobin for the 4th CO molecule, has been determined for human adult hemoglobin (HbA) as a function of pH and the presence of organic phosphates by measuring the kinetic parameters for the reacti... | [
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PMID:10303 | Isolation and partial characterization of monophosphoglycerate mutase from human erythrocytes. | Monophosphoglycerate mutase has been purified to homogeneity from outdated human erythrocytes as indicated by exclusion chromatography, polyacrylamide gel electrophoresis, and equilibrium centrifugation. Occasionally, the recommended purification procedure yields a small amount (3% or less) of a single extraneous prote... | Isolation and partial characterization of monophosphoglycerate mutase from human erythrocytes. Monophosphoglycerate mutase has been purified to homogeneity from outdated human erythrocytes as indicated by exclusion chromatography, polyacrylamide gel electrophoresis, and equilibrium centrifugation. Occasionally, the rec... | [
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PMID:10304 | Conversion of proparathyroid hormone to parathyroid hormone by a particulate enzyme of the parathyroid gland. | The conversion of proparathyroid hormone (proparathormone) to parathyroid hormone (parathormone) by subcellular fractions of the bovine parathyroid has been investigated. The identification of the conversion product as parathormone was established by its elution postion during ion exchange chromatography and gel filtra... | Conversion of proparathyroid hormone to parathyroid hormone by a particulate enzyme of the parathyroid gland. The conversion of proparathyroid hormone (proparathormone) to parathyroid hormone (parathormone) by subcellular fractions of the bovine parathyroid has been investigated. The identification of the conversion pr... | [
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PMID:10305 | Quantitative aspects of relationship between glucose 6-phosphate transport and hydrolysis for liver microsomal glucose-6-phosphatase system. Selective thermal inactivation of catalytic component in situ at acid pH. | Studies of the thermal stability of rat liver glucose-6-phosphatase (EC 3.1.3.9) were carried out to further elevate the proposal that the enzymic activity is the result of the coupling of a glucose-6-P-specific translocase and a nonspecific phosphohydrolase-phosphotransferase. Inactivation was observed when micorsomes... | Quantitative aspects of relationship between glucose 6-phosphate transport and hydrolysis for liver microsomal glucose-6-phosphatase system. Selective thermal inactivation of catalytic component in situ at acid pH. Studies of the thermal stability of rat liver glucose-6-phosphatase (EC 3.1.3.9) were carried out to furt... | [
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PMID:10306 | Acid-induced phosphorylation of adenosine 5'-diphosphate bound to coupling factor 1 in spinach chloroplast thylakoids. | Adenosine 5'-diphosphate, bound to coupling factor 1 (CF1) in spinach chloroplast thylakoids, is in part converted to adenosine 5'-triphosphate, upon injection of the thylakoids into strong acids in the dark. Bound phosphate serves as the phosphoryl donor for this uncoupler-insensitive conversion. Exposure of the thyla... | Acid-induced phosphorylation of adenosine 5'-diphosphate bound to coupling factor 1 in spinach chloroplast thylakoids. Adenosine 5'-diphosphate, bound to coupling factor 1 (CF1) in spinach chloroplast thylakoids, is in part converted to adenosine 5'-triphosphate, upon injection of the thylakoids into strong acids in th... | [
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PMID:10307 | An in vitro investigation of the anodic polarization and capacitance behavior of 316-L stainless steel. | Determinations were made of how the corrosion-resistant properties of the passive film on 316-L stainless steel are influenced by the material's mechanical and surface states, and the variable pH and PO2 conditions of the interstitial fluid. Cold-rolled and annealed specimens were surface-prepared, commercially and in ... | An in vitro investigation of the anodic polarization and capacitance behavior of 316-L stainless steel. Determinations were made of how the corrosion-resistant properties of the passive film on 316-L stainless steel are influenced by the material's mechanical and surface states, and the variable pH and PO2 conditions o... | [
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PMID:10308 | Secretion of old versus new exportable protein in rat parotid slics. Control by neurotransmitters. | The possibility that old and new secretory granules do not mix and that older exportable protein can be secreted preferentially was tested on parotid gland in vitro. Slices from fasted animals were pulse labeled for 3 min with L-[3H]leucine. Subcellular fractionstion showed that after 1 90-min chase period, the formati... | Secretion of old versus new exportable protein in rat parotid slics. Control by neurotransmitters. The possibility that old and new secretory granules do not mix and that older exportable protein can be secreted preferentially was tested on parotid gland in vitro. Slices from fasted animals were pulse labeled for 3 min... | [
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PMID:10309 | The microsporidian spore invasion tube. The ultrastructure, isolation, and characterization of the protein comprising the tube. | The extrusion apparatus of the microsporidian parasitic protozoan Nosema michaelis discharges an invasion (or polar) tube with a velocity suitalbe for piercing cells and injecting infective sporoplasm. The tube is composed of a polar tube protein (PTP) which consists of a single, low molecular weight polypeptide slight... | The microsporidian spore invasion tube. The ultrastructure, isolation, and characterization of the protein comprising the tube. The extrusion apparatus of the microsporidian parasitic protozoan Nosema michaelis discharges an invasion (or polar) tube with a velocity suitalbe for piercing cells and injecting infective sp... | [
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PMID:10310 | Adaptive enhancement of amino acid uptake and exodus by thymic lymphocytes: influence of pH. | Entry of certain free amino acids (alpha aminoisobutyric acid (AIB), alanine and proline), but not of leucine into rat thymic lymphocytes increased progressively when the cells were incubated in amino acid deficient medium. Actinomycin D, cycloheximide, or a high concentration of AIB abolished the time-related increase... | Adaptive enhancement of amino acid uptake and exodus by thymic lymphocytes: influence of pH. Entry of certain free amino acids (alpha aminoisobutyric acid (AIB), alanine and proline), but not of leucine into rat thymic lymphocytes increased progressively when the cells were incubated in amino acid deficient medium. Act... | [
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PMID:10311 | Lysosomal hydrolase secretion by Tetrahymena: a comparison of several intralysosomal enzymes with the isoenzymes released into the medium. | Tetrahymena pyriformis were grown in proteose-peptone medium and then washed and incubated in a dilute salt solution for one hour. The cells were then discarded and the lysosomal hydrolases that had been secreted were subjected to DEAE cellulose column chromatography. At least three isoenzymes of acid phosphatase, thre... | Lysosomal hydrolase secretion by Tetrahymena: a comparison of several intralysosomal enzymes with the isoenzymes released into the medium. Tetrahymena pyriformis were grown in proteose-peptone medium and then washed and incubated in a dilute salt solution for one hour. The cells were then discarded and the lysosomal hy... | [
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PMID:10312 | Synthesis of a liver enzyme in hybrid cells. | Rat hepatoma cells were fused with cells of an established mouse lymphoma line, with normal diploid mouse macrophages, lymphocytes and fibroblasts and with normal diploid rat macrophages and lymphocytes. The liver-specific enzyme tyrosine aminotransferase was produced by almost all the hybrid cells, but usually at a lo... | Synthesis of a liver enzyme in hybrid cells. Rat hepatoma cells were fused with cells of an established mouse lymphoma line, with normal diploid mouse macrophages, lymphocytes and fibroblasts and with normal diploid rat macrophages and lymphocytes. The liver-specific enzyme tyrosine aminotransferase was produced by alm... | [
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PMID:10313 | [Zollinger-Ellison syndrome and parathyroid adenoma. Limits of Wermer's syndrome]. | The authors report the case of a patient with pancreatic and parathyroid adenomatosis and discuss whether it belongs to Wermer's syndrome. After a study of the various possible endocrine involvements, the complexity of hormonal inter-relations is studied, the prognosis and classification of multiple endocrine tumours a... | [Zollinger-Ellison syndrome and parathyroid adenoma. Limits of Wermer's syndrome]. The authors report the case of a patient with pancreatic and parathyroid adenomatosis and discuss whether it belongs to Wermer's syndrome. After a study of the various possible endocrine involvements, the complexity of hormonal inter-rel... | [
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PMID:10314 | Ion-pair chromatography of acidic drug metabolites and endogenic compounds. | Liquid-liquid chromatographic systems based on ion-pair partition with silica microparticles as the support for the stationary phase have been used for the separation of anionic compounds of biochemical and pharmacological interest. A high separating efficiency can be obtained with both aqueous and organic mobile phase... | Ion-pair chromatography of acidic drug metabolites and endogenic compounds. Liquid-liquid chromatographic systems based on ion-pair partition with silica microparticles as the support for the stationary phase have been used for the separation of anionic compounds of biochemical and pharmacological interest. A high sepa... | [
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PMID:10315 | Analysis of the acidic fraction of marijuana smoke condensate by capillary gas chromatography-mass spectrometry. | A method for the analysis of organic acids and phenols isolated from marijuana smoke condensate has been developed. Comparative analyses of standard tobacoo, Mexican, and Turkish marijuana smoke condensates carried out by means of capillary gas chromatography indicated both qualitative and quantitative changes in the c... | Analysis of the acidic fraction of marijuana smoke condensate by capillary gas chromatography-mass spectrometry. A method for the analysis of organic acids and phenols isolated from marijuana smoke condensate has been developed. Comparative analyses of standard tobacoo, Mexican, and Turkish marijuana smoke condensates ... | [
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PMID:10316 | Electron capture and multiple ion detection of benzodiazepine esters in pharmacokinetic studies. | A sensitive and highly specific gas-liquid chromatographic method is described for the determination of benzodiazepine esters. The method involves the extraction of pivoxazepam and 2'-chloropivoxazepam from blood and urine samples and the hydrolysis of both drugs with strong acid to the corresponding 2-amino-5-chlorobe... | Electron capture and multiple ion detection of benzodiazepine esters in pharmacokinetic studies. A sensitive and highly specific gas-liquid chromatographic method is described for the determination of benzodiazepine esters. The method involves the extraction of pivoxazepam and 2'-chloropivoxazepam from blood and urine ... | [
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PMID:10317 | Characterization of bacteroides melaninogenicus. | Fifty-eight human isolates of Bacteroides melaninogenicus, 42 from a variety of clinical infections and the rest from normal flora, were studied for pigment production and ultraviolet light fluorescence and by forty biochemical and other tests, including end-product analysis by gas-liquid chromatography. In a number of... | Characterization of bacteroides melaninogenicus. Fifty-eight human isolates of Bacteroides melaninogenicus, 42 from a variety of clinical infections and the rest from normal flora, were studied for pigment production and ultraviolet light fluorescence and by forty biochemical and other tests, including end-product anal... | [
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PMID:10318 | Recent rural health research. | Recent rural health research may be examined in two ways: needs and solutions. A definition of needs requires an evaluation of the social factors that affect the expectations and the behavior of both the provider and the consumer. Three types of solutions should be considered: the appropriate utilization of manpower, i... | Recent rural health research. Recent rural health research may be examined in two ways: needs and solutions. A definition of needs requires an evaluation of the social factors that affect the expectations and the behavior of both the provider and the consumer. Three types of solutions should be considered: the appropri... | [
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PMID:10331 | Mouse ovarian alkaline phosphatase activities that respond to gonadotropins: histochemical and biochemical studies. | Alkaline phosphatase activity was measured in whole ovarian homogenates from pre-pubertal mice of different ages, with and without prior injection of human chorionic gonadotropin. Alkaline phosphatase activity was also scored in the different cell types in sections of similar ovaries, using two distinct histochemical p... | Mouse ovarian alkaline phosphatase activities that respond to gonadotropins: histochemical and biochemical studies. Alkaline phosphatase activity was measured in whole ovarian homogenates from pre-pubertal mice of different ages, with and without prior injection of human chorionic gonadotropin. Alkaline phosphatase act... | [
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PMID:10332 | The occurrence of salmonellas, mycobacteria and pathogenic strains of Escherichia coli in pig slurry. | Ninety-eight samples of pig slurry from 54 farms were examined for the presence of salmonellas, porcine enteropathogenic strains of haemolytic Escherichia coli and mycobacteria. Salmonellas were isolated from 12 farms (22%) and enteropathogenic E. coli from 13 farms (24%). Pathogenic mycobacteria were not isolated. Sal... | The occurrence of salmonellas, mycobacteria and pathogenic strains of Escherichia coli in pig slurry. Ninety-eight samples of pig slurry from 54 farms were examined for the presence of salmonellas, porcine enteropathogenic strains of haemolytic Escherichia coli and mycobacteria. Salmonellas were isolated from 12 farms ... | [
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PMID:10333 | Detection of serum proteins in the electrophoretic patterns of total proteins of mycoplasma cells. | The contamination of mycoplasma cell preparations by serum proteins originating from culture medium was studied. A. laidlawii and M. arthritidis cells were grown in the presence of [14C]-aminoacids, and the cells were washed with 0-9% NaC1 by threefold centrifugation. Total proteins of the washed cells were analysed by... | Detection of serum proteins in the electrophoretic patterns of total proteins of mycoplasma cells. The contamination of mycoplasma cell preparations by serum proteins originating from culture medium was studied. A. laidlawii and M. arthritidis cells were grown in the presence of [14C]-aminoacids, and the cells were was... | [
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PMID:10334 | Comparison of the inactivation of IgM and IgG complement fixation sites by acid and base. | Rabbit IgM antibodies to denatured mammalian or T6 bacteriophage DNA or poly(A)-poly(U) irreversibly lost complement-(C) fixation reactivity on exposure to low pH and reneutralization, with a halving of the complement-fixation titer occurring after treatment at about pH 3. The titers of IgG antibodies to denatured phag... | Comparison of the inactivation of IgM and IgG complement fixation sites by acid and base. Rabbit IgM antibodies to denatured mammalian or T6 bacteriophage DNA or poly(A)-poly(U) irreversibly lost complement-(C) fixation reactivity on exposure to low pH and reneutralization, with a halving of the complement-fixation tit... | [
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PMID:10335 | Genetic control of the antibody response to type III pneumococcal polysaccharide in mice. III. Analysis of genes governing the expression of regulatory T cell activity. | Recombinant-inbred strains of mice, as well as the progenitor strains from which they were derived, were evaluated with respect to the capacity of B cells to respond to an optimally immunogenic dose of Type III pneumococcal polysaccharide (SSS-III) and the amount of suppressor and amplifier T cell activity present. Non... | Genetic control of the antibody response to type III pneumococcal polysaccharide in mice. III. Analysis of genes governing the expression of regulatory T cell activity. Recombinant-inbred strains of mice, as well as the progenitor strains from which they were derived, were evaluated with respect to the capacity of B ce... | [
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PMID:10336 | Bacterial interference by oropharynegeal and clinical isolates of anaerobic bacteria. | Anaerobic isolates were tested for bacterial inhibitory activity. Of 144 isolates, 102 were from oropharynegeal washings, and 42 were from clinical specimens. Thirteen facultative bacterial species (seven members of the Enterobacteriaceae and six species of gram-positive cocci) were used as indicators of inhibition. El... | Bacterial interference by oropharynegeal and clinical isolates of anaerobic bacteria. Anaerobic isolates were tested for bacterial inhibitory activity. Of 144 isolates, 102 were from oropharynegeal washings, and 42 were from clinical specimens. Thirteen facultative bacterial species (seven members of the Enterobacteria... | [
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PMID:10338 | Inhibition of pituitary prolactin secretion by human placental lactogen in rats. | Intact female rats given twice daily injections of 1 mg human placental lactogen (HPL) showed continued dioestrous vaginal smears and their ovarian corpora lutea were found to be hypertrophied and functiona. The serum prolactin level was significantly lower in these rats than in the controls at dioestrus as well as at ... | Inhibition of pituitary prolactin secretion by human placental lactogen in rats. Intact female rats given twice daily injections of 1 mg human placental lactogen (HPL) showed continued dioestrous vaginal smears and their ovarian corpora lutea were found to be hypertrophied and functiona. The serum prolactin level was s... | [
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PMID:10339 | A comparison of the cholinesterases of an oyster (Crassostrea virginica) and a clam (Macrocallista nimbosa). | Cholinesterase activities in the hearts and ganglia of an oyster (Crassostrea virginica) and a venerid clam (Macrocallista nimbosa) were measured and compared. Tissue extracts were partially purified by ammonium sulfate fractionation followed by gel column chromatography. Enzymatic activity was assayed spectrophotometr... | A comparison of the cholinesterases of an oyster (Crassostrea virginica) and a clam (Macrocallista nimbosa). Cholinesterase activities in the hearts and ganglia of an oyster (Crassostrea virginica) and a venerid clam (Macrocallista nimbosa) were measured and compared. Tissue extracts were partially purified by ammonium... | [
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PMID:10343 | Factors affecting the uptake and metabolism of soluble carbohydrates by the rumen ciliate Dasytricha ruminantium isolated from ovine rumen contents by filtration. | A filtration technique is described whereby metabolically-active suspensions of Dasytricha ruminantium can be isolated from rumen contents with negligible contamination by bacteria or other protozoa. The effects of environmental factors and of the diurnal cycle of the rumen on the uptake and metabolism of soluble carbo... | Factors affecting the uptake and metabolism of soluble carbohydrates by the rumen ciliate Dasytricha ruminantium isolated from ovine rumen contents by filtration. A filtration technique is described whereby metabolically-active suspensions of Dasytricha ruminantium can be isolated from rumen contents with negligible co... | [
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PMID:10344 | Production of phospholipase C (alpha-toxin), haemolysins and lethal toxins by Clostridium perfringens types A to D. | To obtain high yields of extracellular enzymes and toxins for immunological analysis, type culture collection strains of Clostridium perfringens types A to D and 28 fresh isolates of C. perfringens type A from humans were grown in fermenters under controlled conditions in a pre-reduced proteose peptone medium. The type... | Production of phospholipase C (alpha-toxin), haemolysins and lethal toxins by Clostridium perfringens types A to D. To obtain high yields of extracellular enzymes and toxins for immunological analysis, type culture collection strains of Clostridium perfringens types A to D and 28 fresh isolates of C. perfringens type A... | [
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PMID:10345 | Role of wall phosphomannan in flocculation of Saccharomyces cerevisiae. | Treatment with 60% hydrofluoric acid (HF) removed most of the phosphorus and small amounts of mannan, glucan and protein from walls of two non-flocculent strains (NCYC366 and NCYC1004) and two flocculent strains (NCYC1005 and NCYC1063) of Saccharomyces cerevisiae. Organisms of all strains showed increased flocculating ... | Role of wall phosphomannan in flocculation of Saccharomyces cerevisiae. Treatment with 60% hydrofluoric acid (HF) removed most of the phosphorus and small amounts of mannan, glucan and protein from walls of two non-flocculent strains (NCYC366 and NCYC1004) and two flocculent strains (NCYC1005 and NCYC1063) of Saccharom... | [
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PMID:10346 | Purification and characterization of phosphoglycerate mutase from methanol-grown Hyphomicrobium X and Pseudomonas AM1. | Phosphoglycerate mutase has been purified from methanol-grown Hyphomicrobium X and Pseudomonas AMI by acid precipitation, heat treatment, ammonium sulphate fractionation, Sephadex G-50 gel filtration and DEAE-cellulose column chromatography. The purification attained using the Hyphomicrobium X extract was 72-fold, and ... | Purification and characterization of phosphoglycerate mutase from methanol-grown Hyphomicrobium X and Pseudomonas AM1. Phosphoglycerate mutase has been purified from methanol-grown Hyphomicrobium X and Pseudomonas AMI by acid precipitation, heat treatment, ammonium sulphate fractionation, Sephadex G-50 gel filtration a... | [
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PMID:10348 | The effects of alkalinity and hypertonicity on the morphology and motility of Leptospira interrogans (biflexa) strain B16. | Effects of alkalinity and hypertonicity on the motile behaviour of Leptospira interrogans (biflexa) B16 were observed, quantified, and compared with effects previously shown by similar factors on the motility of eubacteria. Leptospira interrogans tolerated relatively high concentrations of hydroxide ions. Motility simi... | The effects of alkalinity and hypertonicity on the morphology and motility of Leptospira interrogans (biflexa) strain B16. Effects of alkalinity and hypertonicity on the motile behaviour of Leptospira interrogans (biflexa) B16 were observed, quantified, and compared with effects previously shown by similar factors on t... | [
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PMID:10349 | Autolysis in strains of viridans streptococci. | Seven strains of viridans streptococci of the species Streptococcus sanguis, S. mutans and S. mitis were investigated for autolysis. The effect of pH, salt concentration and temperature on the autolytic process was studied in Na2HPO4/NaH2PO4 buffer. Whole cells and walls of all strains autolysed most rapidly at pH valu... | Autolysis in strains of viridans streptococci. Seven strains of viridans streptococci of the species Streptococcus sanguis, S. mutans and S. mitis were investigated for autolysis. The effect of pH, salt concentration and temperature on the autolytic process was studied in Na2HPO4/NaH2PO4 buffer. Whole cells and walls o... | [
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PMID:10350 | Antipsychotic drugs and dopamine-mediated responses in Aplysia neurons. | The effect of antipsychotic drugs was tested on responses to micro-electrophoretically applied dopamine, acetylcholine and 5-hydroxytryptamine in identified neurons of the marine gastropod Aplysia californica. Fluphenazine was able to depress the response to DA in concentration of 10 muM, with 100 muM DA-responses of m... | Antipsychotic drugs and dopamine-mediated responses in Aplysia neurons. The effect of antipsychotic drugs was tested on responses to micro-electrophoretically applied dopamine, acetylcholine and 5-hydroxytryptamine in identified neurons of the marine gastropod Aplysia californica. Fluphenazine was able to depress the r... | [
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PMID:10351 | N-substituted maleimide inactivation of the response to taste cell stimulation. | N-Ethylmaleimide (NEM) irreversibly inactivates the response of gustatory cells to stimulation by NaCl, sucrose and hydrogen ions. The rate of inactivation can be measured by monitoring the decay of NaCl-stimulated summated electrophysiological activity at the chorda tympani nerve in the presence of NEM. The observed p... | N-substituted maleimide inactivation of the response to taste cell stimulation. N-Ethylmaleimide (NEM) irreversibly inactivates the response of gustatory cells to stimulation by NaCl, sucrose and hydrogen ions. The rate of inactivation can be measured by monitoring the decay of NaCl-stimulated summated electrophysiolog... | [
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PMID:10352 | Increased phosphorylated components of erythrocyte membrane spectrin band II with reference to Duchenne muscular dystrophy. | Increased erythrocyte band II phosphorylation has been demonstrated in patients with Duchenne muscular dystrophy (DMD). Band II has been purified by preparative sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis. Isoelectric focusing of purified band II from which SDS has been removed reveals heterogeneity... | Increased phosphorylated components of erythrocyte membrane spectrin band II with reference to Duchenne muscular dystrophy. Increased erythrocyte band II phosphorylation has been demonstrated in patients with Duchenne muscular dystrophy (DMD). Band II has been purified by preparative sodium dodecyl sulfate (SDS)-polyac... | [
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PMID:10353 | The histochemical profile of the human masseter. An autopsy and biopsy study. | A histochemical study has been carried out upon samples of muscle obtained from the human masseter. Sixteen specimens obtained either at autopsy or biopsy have shown that the middle and deep portions of the muscle contain fibres which in their size, histochemical staining properties and number correspond to the appeara... | The histochemical profile of the human masseter. An autopsy and biopsy study. A histochemical study has been carried out upon samples of muscle obtained from the human masseter. Sixteen specimens obtained either at autopsy or biopsy have shown that the middle and deep portions of the muscle contain fibres which in thei... | [
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PMID:10358 | Effects of stock or purified diet on rat liver enzymes involved in the synthesis of dimethyl selenide. | Rats fed either a stock deit or a purified diet based on casein were tested for their ability to convert 75Se-sodium selenite to volatile selenium (dimethyl selenide) in vivo. This conversion was also studied in liver and kidney in vitro. When injected with a subacute dose of selenite (2 mg Se/kg), rats previously fed ... | Effects of stock or purified diet on rat liver enzymes involved in the synthesis of dimethyl selenide. Rats fed either a stock deit or a purified diet based on casein were tested for their ability to convert 75Se-sodium selenite to volatile selenium (dimethyl selenide) in vivo. This conversion was also studied in liver... | [
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PMID:10359 | Nitrogen intake and tumorigenesis in rats injected with 1,2-dimethylhydrazine. | Tumor incidence was studied in 1,2-dimethylhydrazine (DMH) injected male rats assigned at weaning to isoenergetic casein-sucorse deits containing 7.5%, 15%, or 22.5% protein with or without 2.5% urea. Twenty rats fed each diet were given weekly intraperitoneal injections of DMH (15 mg/kg body weight/week) for the first... | Nitrogen intake and tumorigenesis in rats injected with 1,2-dimethylhydrazine. Tumor incidence was studied in 1,2-dimethylhydrazine (DMH) injected male rats assigned at weaning to isoenergetic casein-sucorse deits containing 7.5%, 15%, or 22.5% protein with or without 2.5% urea. Twenty rats fed each diet were given wee... | [
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PMID:10360 | Digestion and absorption of bovine milk xanthine oxidase and its role as an aldehyde oxidase. | The effects of acidic and intestinal proteolytic environments on bovine milk xanthine oxidase (XO) activity were determined in order to evaluate the extent to which this enzyme was absorbed in biologically active form. The inhibition of XO by folic acid and the relative affinities of XO for the oxidation of palmitaldeh... | Digestion and absorption of bovine milk xanthine oxidase and its role as an aldehyde oxidase. The effects of acidic and intestinal proteolytic environments on bovine milk xanthine oxidase (XO) activity were determined in order to evaluate the extent to which this enzyme was absorbed in biologically active form. The inh... | [
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PMID:10363 | The formation of a platelet adhesive factor by disruption of the creatine phosphokinase molecule. | It was discovered that the product of a mix containing the enzyme creatine phosphokinase (CPK) and either glutathione (GSH) or cysteine caused platelets to adhere together in vitro. This platelet adhesive factor (PAF) was formed as CPK enzyme activity declined. An alternative method for the destruction of enzyme activi... | The formation of a platelet adhesive factor by disruption of the creatine phosphokinase molecule. It was discovered that the product of a mix containing the enzyme creatine phosphokinase (CPK) and either glutathione (GSH) or cysteine caused platelets to adhere together in vitro. This platelet adhesive factor (PAF) was ... | [
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PMID:10365 | Proteinase activity in Ascaris suum eggs, hatching fluid, and excretions-secretions. | Hatching fluid and the excretions and secretions (E.S.) of hatched larvae of Ascaris suum revealed proteinase activity when assayed by 2 different procedures employing collagen or casein as substrates. Both assays apparently detected similar levels of proteinase activity in hatching fluid and E.S. of hatched larvae. Th... | Proteinase activity in Ascaris suum eggs, hatching fluid, and excretions-secretions. Hatching fluid and the excretions and secretions (E.S.) of hatched larvae of Ascaris suum revealed proteinase activity when assayed by 2 different procedures employing collagen or casein as substrates. Both assays apparently detected s... | [
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PMID:10366 | Prostaglandins and leucotaxis. | Freshly prepared solutions of prostaglandin E1 exhibit chemotactic activity against rabbit polymorphonuclear leucocytes harvested from the peritoneal cavity but are devoid of such activity either against similar cells obtained from the rat or against polymorphonuclear leucocytes obtained from the blood of the rabbit, r... | Prostaglandins and leucotaxis. Freshly prepared solutions of prostaglandin E1 exhibit chemotactic activity against rabbit polymorphonuclear leucocytes harvested from the peritoneal cavity but are devoid of such activity either against similar cells obtained from the rat or against polymorphonuclear leucocytes obtained ... | [
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PMID:10367 | Pharmacological studies with adenine, adenosine and some phosphorylated derivatives on guinea-pig tracheal muscle. | Adenine, adenosine and three adenine nucleotides all caused relaxation of the guinea-pig trachea. The relaxation to the nucleotides was often preceded by a contraction. The response to adenosine and the nucleotides, but not adenine, was potentiated by dipyridamole. Imidazole inhibited the response to adenine alone. Pro... | Pharmacological studies with adenine, adenosine and some phosphorylated derivatives on guinea-pig tracheal muscle. Adenine, adenosine and three adenine nucleotides all caused relaxation of the guinea-pig trachea. The relaxation to the nucleotides was often preceded by a contraction. The response to adenosine and the nu... | [
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PMID:10368 | Interactions of bradykinin, prostaglandin E1, 5-hydroxytryptamine, histamine and adenosine-5'-triphosphate on the dry leakage response in rat skin. | Dye leakage in rats produced by intracutaneous injections of irritants was quantitated using an azovan blue technique. Concentration-response lines were obtained for irritants alone and in presence of constant concentrations of other irritants. 5-Hydroxytryptamine (5-HT) (10-7M) potentiated histamine, bradykinin and pr... | Interactions of bradykinin, prostaglandin E1, 5-hydroxytryptamine, histamine and adenosine-5'-triphosphate on the dry leakage response in rat skin. Dye leakage in rats produced by intracutaneous injections of irritants was quantitated using an azovan blue technique. Concentration-response lines were obtained for irrita... | [
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PMID:10369 | Polymorphism of disopyramide. | Two crystal forms of disopyramide have been characterized using X-ray diffraction, differential scanning calorimetry and infrared spectroscopy. The kinetics of the solid state transformation of Form I to Form II has been analysed using the Prout-Tompkins theory. An activation energy of 144 kJ mol-1 is calculated for th... | Polymorphism of disopyramide. Two crystal forms of disopyramide have been characterized using X-ray diffraction, differential scanning calorimetry and infrared spectroscopy. The kinetics of the solid state transformation of Form I to Form II has been analysed using the Prout-Tompkins theory. An activation energy of 144... | [
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PMID:10370 | Aggregation of antiacetylcholine drugs in aqueous solution: monomer concentrations in non-micellar drug systems. | The self-association of the antiacetylcholine drugs, propantheline bromide, methantheline bromide and methixene hydrochloride in aqueous solution, has been examined by surface tension, light scattering and conductimetric methods. Surface tension graphs were similar to those of conventional surfactants, showing apparent... | Aggregation of antiacetylcholine drugs in aqueous solution: monomer concentrations in non-micellar drug systems. The self-association of the antiacetylcholine drugs, propantheline bromide, methantheline bromide and methixene hydrochloride in aqueous solution, has been examined by surface tension, light scattering and c... | [
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PMID:10371 | Stability of salicylamide-caffeine complex at different temperatures and its thermodynamic parameters. | The stability constants for formation of complexes of salicylamide with caffeine have been measured between 15 and 45degrees, by means of the solubility method. There was a linear solubility increase at all temperatures but phase diagrams indicated that at 15 and 25degrees an additional phase was formed which was found... | Stability of salicylamide-caffeine complex at different temperatures and its thermodynamic parameters. The stability constants for formation of complexes of salicylamide with caffeine have been measured between 15 and 45degrees, by means of the solubility method. There was a linear solubility increase at all temperatur... | [
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... |
PMID:10387 | 5-Hydroxytryptamine is a substrate for both species of monoamine oxidase in beef heart mitochondria. | The activity of beef heart mitochondrial monoamine oxidase towards 5-hydroxytryptamine (5-HT) is inhibited by the selective inhibitors clorgyline, PCO [5-phenyl-3-(N-cyclopropyl)-ethylamine-1,2,4-oxidiazole] and Deprenyl with a biphasic dependence on the inhibitor concentration. The activities towards tyramine, dopamin... | 5-Hydroxytryptamine is a substrate for both species of monoamine oxidase in beef heart mitochondria. The activity of beef heart mitochondrial monoamine oxidase towards 5-hydroxytryptamine (5-HT) is inhibited by the selective inhibitors clorgyline, PCO [5-phenyl-3-(N-cyclopropyl)-ethylamine-1,2,4-oxidiazole] and Depreny... | [
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0... |
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