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PMID:10388 | Bioanalysis of picomole amounts of acetylcholine by ion-pair partition chromatography applied to rat sciatic nerve. | A method for determination of acetylcholine in small, discrete biological objects by use of ion-pair technique has been developed. Acetylcholine is extracted as an ion pair with 3,5-di-t-butyl-2-hydroxybenzenesulphonate and separated from co-extracted components by ion-pair partition chromatography with picrate as the ... | Bioanalysis of picomole amounts of acetylcholine by ion-pair partition chromatography applied to rat sciatic nerve. A method for determination of acetylcholine in small, discrete biological objects by use of ion-pair technique has been developed. Acetylcholine is extracted as an ion pair with 3,5-di-t-butyl-2-hydroxybe... | [
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PMID:10389 | The effects of administering N-(2-benzoyloxyethyl) norfenfluramine to rats on the hepatic synthesis of glycerolipids. | N-(2-Benzoyloxyethyl) norfenfluramine (S-780) was administered to rats by stomach tube at a dose of 50 mg kg-1 of body weight. Livers of the rats which were given an acute dose of the drug synthesized more triacylglycerol, phosphatidylcholine and phosphatidylethanolamine from [1,3-3H]glycerol and [14C]palmitate than di... | The effects of administering N-(2-benzoyloxyethyl) norfenfluramine to rats on the hepatic synthesis of glycerolipids. N-(2-Benzoyloxyethyl) norfenfluramine (S-780) was administered to rats by stomach tube at a dose of 50 mg kg-1 of body weight. Livers of the rats which were given an acute dose of the drug synthesized m... | [
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PMID:10390 | Influence of various substances on prostaglandin biosynthesis by guinea-pig chopped lung. | Guinea-pig chopped lung tissue was used to investigate the inhibitory effect of various steroidal and non-steroidal anti-inflammatory agents, antipyretics, analgesics, local anaesthetics and psychotropic drugs on mechanically induced release of prostaglandin-like material. Low concentrations of non-steroidal anti-infla... | Influence of various substances on prostaglandin biosynthesis by guinea-pig chopped lung. Guinea-pig chopped lung tissue was used to investigate the inhibitory effect of various steroidal and non-steroidal anti-inflammatory agents, antipyretics, analgesics, local anaesthetics and psychotropic drugs on mechanically indu... | [
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PMID:10391 | Metabolic N-oxidation of atropine, hyoscine and the corresponding nor-alkaloids by guinea-pig liver microsomal preparations. | Incubation of guinea-pig liver microsomal preparations with atropine or hyoscine resulted in the formation of the corresponding nor-alkaloids and both isomers of atropine N-oxide from atropine and one isomer of hyoscine N-oxide from hyoscine. Separate incubations of guinea-pig liver microsomal preparations with nor-atr... | Metabolic N-oxidation of atropine, hyoscine and the corresponding nor-alkaloids by guinea-pig liver microsomal preparations. Incubation of guinea-pig liver microsomal preparations with atropine or hyoscine resulted in the formation of the corresponding nor-alkaloids and both isomers of atropine N-oxide from atropine an... | [
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PMID:10392 | The microsomal N-oxidation of phentermine. | The microsomal N-oxidation of phentermine (Ia) to N-hydroxyphentermine (Ib) and to alpha,alpha-dimethyl-alpha-nitroso-beta-phenylethane (Ic was investigated. Maximum activities were obtained with microsomal (9000 g supernatant and microsomes) fractions of rabbit liver in the presence of an NADPH generating system. Incu... | The microsomal N-oxidation of phentermine. The microsomal N-oxidation of phentermine (Ia) to N-hydroxyphentermine (Ib) and to alpha,alpha-dimethyl-alpha-nitroso-beta-phenylethane (Ic was investigated. Maximum activities were obtained with microsomal (9000 g supernatant and microsomes) fractions of rabbit liver in the p... | [
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PMID:10393 | A new class of irreversible muscarinic antagonists: beta-haloethylamine furoates. | The synthesis of a class of ultra-long acting muscarinic antagonists is described. Furthermore, it is noted that the stability of the, in situ, aziridinium ion is sufficiently great so that these agents can be used to study the effect of temperature upon the conformation of the muscarinic cholinoceptor. The inactivatio... | A new class of irreversible muscarinic antagonists: beta-haloethylamine furoates. The synthesis of a class of ultra-long acting muscarinic antagonists is described. Furthermore, it is noted that the stability of the, in situ, aziridinium ion is sufficiently great so that these agents can be used to study the effect of ... | [
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PMID:10394 | The influence of polyvinylpyrrolidone on the solution and bioavailability of hydrochlorothiazide. | The dissolution properties of hydrochlorothiazide-PVP 10 000 mechanical mix and coprecipitate systems were qualitatively similar to those previously reported using hydroflumethiazide. Quantitative differences were dependent on the proportion of PVP present, its molecular weight and method of incorporation. Cumulative u... | The influence of polyvinylpyrrolidone on the solution and bioavailability of hydrochlorothiazide. The dissolution properties of hydrochlorothiazide-PVP 10 000 mechanical mix and coprecipitate systems were qualitatively similar to those previously reported using hydroflumethiazide. Quantitative differences were dependen... | [
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PMID:10395 | Data point weighting in pharmacokinetic analysis: intravenous paracetamol in man. | Compartmental analysis of plasma paracetamol concentrations following intravenous injection of 12 mg kg-1 in aqueous solution to normal subjects was performed using analogue and digital computer methods. Using a "simplex" non-linear optimization procedure, the pharmacokinetic parameters were found to be influenced cons... | Data point weighting in pharmacokinetic analysis: intravenous paracetamol in man. Compartmental analysis of plasma paracetamol concentrations following intravenous injection of 12 mg kg-1 in aqueous solution to normal subjects was performed using analogue and digital computer methods. Using a "simplex" non-linear optim... | [
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PMID:10408 | Electrochemistry of drug action I: electrooreduction of ferredoxins. | Ferredoxin serves as an electron carrier in the oxidation-reduction system in anaerobic microorganisms, transferring electrons from a low potential donor to electron-accepting biochemicals. The anaerobicidal activity of some drugs may be due to their interference with the electron transport function of ferredoxin. Two ... | Electrochemistry of drug action I: electrooreduction of ferredoxins. Ferredoxin serves as an electron carrier in the oxidation-reduction system in anaerobic microorganisms, transferring electrons from a low potential donor to electron-accepting biochemicals. The anaerobicidal activity of some drugs may be due to their ... | [
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PMID:10409 | Liquid chromatography in pharmaceutical analysis V: determination of an isoniazid-pyridoxine hydrochloride mixture. | Operating parameters are described for the qualitative and quantitative analysis of an isoniazid-pyridoxine hydrochloride mixture by high-pressure liquid chromatography. Each compound was chromatographed on an octadecyl column, using absolute methanol-water (60:40) (pH 2.5) containing 0.01 M dioctyl sodium sulfosuccina... | Liquid chromatography in pharmaceutical analysis V: determination of an isoniazid-pyridoxine hydrochloride mixture. Operating parameters are described for the qualitative and quantitative analysis of an isoniazid-pyridoxine hydrochloride mixture by high-pressure liquid chromatography. Each compound was chromatographed ... | [
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PMID:10410 | Simple and rapid determination of a new pharmaceutically active amine hydrochloride. | The quantitative analysis of a new pharmaceutically active amine hydrochloride is described. Samples are extracted with chloroform. A yellow amine-dye complex is formed by buffering a sample-bromthymol blue solution at pH 8.5 +/- 0.1 and subsequently extracted with chloroform. The complex is treated with 0.01 N NaOH to... | Simple and rapid determination of a new pharmaceutically active amine hydrochloride. The quantitative analysis of a new pharmaceutically active amine hydrochloride is described. Samples are extracted with chloroform. A yellow amine-dye complex is formed by buffering a sample-bromthymol blue solution at pH 8.5 +/- 0.1 a... | [
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PMID:10411 | Phenylbutazone ionization kinetics. | Phenylbutazone has been associated with bioavailability problems and has shown nonclassical behavior in phase-transport studies. This nonclassical behavior has been attributed, in part, to the fact that phenylbutazone, as a carbon acid, undergoes noninstantaneous ionization kinetics. Instantaneous reaction is an assump... | Phenylbutazone ionization kinetics. Phenylbutazone has been associated with bioavailability problems and has shown nonclassical behavior in phase-transport studies. This nonclassical behavior has been attributed, in part, to the fact that phenylbutazone, as a carbon acid, undergoes noninstantaneous ionization kinetics.... | [
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PMID:10412 | Conversion of cefamandole nafate to cefamandole sodium. | The rate of hydrolysis of the formyl moiety of cefamandole nafate was determined as a function of pH, temperature, and concentration of added sodium carbonate or tromethamine. The reaction rate was sensitive to hydroxide ion in the pH 5.5-8.0 range with half-life values of hours to minutes. Hydrolysis was rapid upon th... | Conversion of cefamandole nafate to cefamandole sodium. The rate of hydrolysis of the formyl moiety of cefamandole nafate was determined as a function of pH, temperature, and concentration of added sodium carbonate or tromethamine. The reaction rate was sensitive to hydroxide ion in the pH 5.5-8.0 range with half-life ... | [
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PMID:10413 | Structure of aluminum hydroxide gel I: initial precipitate. | The initial aluminum hydroxide gel precipitate resulting from the reaction of aluminum chloride or aluminum sulfate with ammonium hydroxide is shown by potentiometric titration, chemical analysis, and the ratio of bound hydroxide to aluminum to fit a polymer model described previously. The formation of polynuclear hydr... | Structure of aluminum hydroxide gel I: initial precipitate. The initial aluminum hydroxide gel precipitate resulting from the reaction of aluminum chloride or aluminum sulfate with ammonium hydroxide is shown by potentiometric titration, chemical analysis, and the ratio of bound hydroxide to aluminum to fit a polymer m... | [
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PMID:10414 | Structure of aluminum hydroxide gel II: aging mechanism. | The aging of aluminum hydroxide gel prepared by the reaction of aluminum chloride and ammonium hydroxide was studied by measurement of pH, acid-consuming capacity, hydroxide to aluminum ratio, chloride activity, and X-ray line broadening. The results were consistent with a polymer model involving particle growth by a d... | Structure of aluminum hydroxide gel II: aging mechanism. The aging of aluminum hydroxide gel prepared by the reaction of aluminum chloride and ammonium hydroxide was studied by measurement of pH, acid-consuming capacity, hydroxide to aluminum ratio, chloride activity, and X-ray line broadening. The results were consist... | [
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PMID:10415 | Structure of aluminum hydroxide gel III: mechanism of stabilization by sorbitol. | The effect of sorbitol on the aging of aluminum hydroxide gel, prepared by the reaction of aluminum chloride solution with strong ammonia solution to a final pH of 7.0, was studied by potentiometric titration, acid-consuming capacity, pH, hydroxide to aluminum ratio, chloride activity, X-ray diffraction, and IR spectro... | Structure of aluminum hydroxide gel III: mechanism of stabilization by sorbitol. The effect of sorbitol on the aging of aluminum hydroxide gel, prepared by the reaction of aluminum chloride solution with strong ammonia solution to a final pH of 7.0, was studied by potentiometric titration, acid-consuming capacity, pH, ... | [
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PMID:10416 | Kinetics and mechanisms of hydrolysis of 1,4-benzodiazepines I: chlordiazepoxide and demoxepam. | Differential absorbance spectroscopy was successfully used to follow the hydrolysis kinetics of chlordiazepoxide and demoxepam from pH 1 to 11. Loss of the methylamino group from chlordiazepoxide produced demoxepam. Demoxepam degraded by a parallel consecutive reaction to 2-amino-5-chlorobenzophenone and a glycine deri... | Kinetics and mechanisms of hydrolysis of 1,4-benzodiazepines I: chlordiazepoxide and demoxepam. Differential absorbance spectroscopy was successfully used to follow the hydrolysis kinetics of chlordiazepoxide and demoxepam from pH 1 to 11. Loss of the methylamino group from chlordiazepoxide produced demoxepam. Demoxepa... | [
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PMID:10417 | Spectrofluorometric determination of hydroflumethiazide in plasma and urine. | A rapid, accurate, sensitive, and reproducible assay for hydroflumethiazide in plasma and urine was developed after studies of its UV and fluorescence spectral properties and partitioning behavior. The assay is based on initial extraction from acidified plasma or urine into ether, back-extraction into basic solution fo... | Spectrofluorometric determination of hydroflumethiazide in plasma and urine. A rapid, accurate, sensitive, and reproducible assay for hydroflumethiazide in plasma and urine was developed after studies of its UV and fluorescence spectral properties and partitioning behavior. The assay is based on initial extraction from... | [
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PMID:10418 | Spectrofluorometric determination of bufuralol in blood and urine. | The benzofuran analog bufuralol, a beta-adrenergic blocker, was determined in blood and urine by a specific and sensitive spectrofluorometric assay. The compound was extracted into ether from blood or urine adjusted to pH 10. The ether extract was separated by TLC to resolve the parent drug from any basic metabolites p... | Spectrofluorometric determination of bufuralol in blood and urine. The benzofuran analog bufuralol, a beta-adrenergic blocker, was determined in blood and urine by a specific and sensitive spectrofluorometric assay. The compound was extracted into ether from blood or urine adjusted to pH 10. The ether extract was separ... | [
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PMID:10419 | Kinetics of acid neutralization by aluminum hydroxide gel. | The rate of acid neutralization by an aluminum hydroxide gel prepared by the reaction of aluminum chloride solution and strong ammonia solution was studied. The decrease in acid-consuming capacity during aging as measured by the USP test is due to a decrease in the rate of reaction rather than to a decrease in equilibr... | Kinetics of acid neutralization by aluminum hydroxide gel. The rate of acid neutralization by an aluminum hydroxide gel prepared by the reaction of aluminum chloride solution and strong ammonia solution was studied. The decrease in acid-consuming capacity during aging as measured by the USP test is due to a decrease in... | [
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PMID:10420 | Effect of histamine and antihistamines on renal hemodynamics and functions in the isolated perfused canine kidney. | Histamine was infused intra-arterially (10-40 mug/min) into isolated blood perfused canine kidneys while functional and hemodynamic parameters were monitored. When perfusion pressure (PP) was kept constant during the infusion of histamine, renal blood flow (RBF) increased from 137 +/- 9 to 181 +/- 9 ml/min (P less than... | Effect of histamine and antihistamines on renal hemodynamics and functions in the isolated perfused canine kidney. Histamine was infused intra-arterially (10-40 mug/min) into isolated blood perfused canine kidneys while functional and hemodynamic parameters were monitored. When perfusion pressure (PP) was kept constant... | [
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PMID:10421 | Phenacetin: renal tubular transport and intrarenal distribution in the dog. | In a total of 22 studies in the anesthetized dog, the renal clearnace of phenacetin was measured over a range of plasma concentrations and at different urinary pH and rates of urine flow. Phenacetin is reabsorbed by passive diffusion. The urine/plasma ratio is essentially unity under all conditions. As measured by ultr... | Phenacetin: renal tubular transport and intrarenal distribution in the dog. In a total of 22 studies in the anesthetized dog, the renal clearnace of phenacetin was measured over a range of plasma concentrations and at different urinary pH and rates of urine flow. Phenacetin is reabsorbed by passive diffusion. The urine... | [
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PMID:10422 | Loperamide binding to opiate receptor sites of brain and myenteric plexus. | Loperamide, a new antidiarrheal agent, was tested to determine whether its biological activity involves binding to opiate receptor sites. Loperamide and morphine competitively inhibited 3H-naloxone binding to homogenates a guinea-pig brain and myenteric plexus. The Kp values obtain in the presence of Na+ were: morphine... | Loperamide binding to opiate receptor sites of brain and myenteric plexus. Loperamide, a new antidiarrheal agent, was tested to determine whether its biological activity involves binding to opiate receptor sites. Loperamide and morphine competitively inhibited 3H-naloxone binding to homogenates a guinea-pig brain and m... | [
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PMID:10423 | Cellular mechanisms of renal tubular transport of I-dopa and its derivatives in the rat: microperfusion studies. | Proximal tubular transport of L-3,4-dihydroxyphenylalanine (L-dopa) and its derivatives were studied in the rat kidney by microperfusion and capillary perfusion techniques in situ. With the use of microperfusion techniques alone, it was found that L-dopa, L-3-methoxy-4-hydroxyphenylalanine, L-tyrosine and L-phenylalani... | Cellular mechanisms of renal tubular transport of I-dopa and its derivatives in the rat: microperfusion studies. Proximal tubular transport of L-3,4-dihydroxyphenylalanine (L-dopa) and its derivatives were studied in the rat kidney by microperfusion and capillary perfusion techniques in situ. With the use of microperfu... | [
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PMID:10424 | Biosynthesis and metabolism of endogenous tyramine and its normal presence in sympathetic nerves. | By use of a sensitive and specific enzymatic isotopic method for the determination of tyramine, the small quantities of this amine which are present endogenously in rat tissues, including brain, heart, kidney and salivary gland, have been quantitated. The levels of tyramine in brain were increased to a similar extent b... | Biosynthesis and metabolism of endogenous tyramine and its normal presence in sympathetic nerves. By use of a sensitive and specific enzymatic isotopic method for the determination of tyramine, the small quantities of this amine which are present endogenously in rat tissues, including brain, heart, kidney and salivary ... | [
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PMID:10425 | The beta adrenergic receptors of chromatophores of the frog, Rana pipiens. | The isolated skin of Rana pipiens was found to be a suitable model for the quantitative study of chromatophore beta adrenergic receptors uninfluenced by prejunctional phenomena. Cumulative concentration-response curves for adrenergic agonists were obtained in preparations in which effective alpha adrenergic blockade ha... | The beta adrenergic receptors of chromatophores of the frog, Rana pipiens. The isolated skin of Rana pipiens was found to be a suitable model for the quantitative study of chromatophore beta adrenergic receptors uninfluenced by prejunctional phenomena. Cumulative concentration-response curves for adrenergic agonists we... | [
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PMID:10426 | A polypeptide (AP-A) from sea anemone (Anthopleura xanthogrammica) with potent positive inotropic action. | Anthopleurin-A (AP-A), a polypeptide with MW ca. 5500 (53 amino acids), isolated from the sea anemone, Anthopleura xanthogrammica (Brandt), elicited a potent positive inotropic effect but without an accompanying chronotropic effect on the isolated cardiac muscles of rat, rabbit, guinea pig and cat. Similarly in dogs an... | A polypeptide (AP-A) from sea anemone (Anthopleura xanthogrammica) with potent positive inotropic action. Anthopleurin-A (AP-A), a polypeptide with MW ca. 5500 (53 amino acids), isolated from the sea anemone, Anthopleura xanthogrammica (Brandt), elicited a potent positive inotropic effect but without an accompanying ch... | [
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PMID:10427 | Isoproterenol antagonism of cardioselective beta adrenergic receptor blocking agents: a comparative study of human and guinea-pig cardiac and bronchial beta adrenergic receptors. | pA2 values against isoproterenol were determined for a number of cardioselective and noncardioselective beta adrenergic receptor blocking agents using human and guinea-pig isolated atrial and bronchial or tracheal preparations to study possible species differences. No significant differences in pA2 values for propranol... | Isoproterenol antagonism of cardioselective beta adrenergic receptor blocking agents: a comparative study of human and guinea-pig cardiac and bronchial beta adrenergic receptors. pA2 values against isoproterenol were determined for a number of cardioselective and noncardioselective beta adrenergic receptor blocking age... | [
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PMID:10428 | Interactions between narcotic analgesics and benzodiazepine derivatives on behavior in the mouse. | Interactions between the benzodiazepine derivatives, diazepam and oxazepam, and the narcotic analgesics, morphine and methadone, were evaluated on locomotor activity and in the tail-flick and hot-plate tests for analgesia in the mouse. The dose-related stimulation of locomotor activity by morphine was reduced by diazep... | Interactions between narcotic analgesics and benzodiazepine derivatives on behavior in the mouse. Interactions between the benzodiazepine derivatives, diazepam and oxazepam, and the narcotic analgesics, morphine and methadone, were evaluated on locomotor activity and in the tail-flick and hot-plate tests for analgesia ... | [
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PMID:10429 | Precipitation of abstinence-like syndrome in morphine-dependent mice by pargyline. | In mice rendered morphine-dependent by pellet implantation for 3 days, the administration of pargyline 6 hours after pellet removal intensified narcotic abstinence behavior, particularly the narcotic withdrawal jumping response. Pargyline, 75 mg/kg i.p., caused a 6- to 9-fold increase in the incidence of jumping in mic... | Precipitation of abstinence-like syndrome in morphine-dependent mice by pargyline. In mice rendered morphine-dependent by pellet implantation for 3 days, the administration of pargyline 6 hours after pellet removal intensified narcotic abstinence behavior, particularly the narcotic withdrawal jumping response. Pargylin... | [
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PMID:10430 | Effect of sodium para-aminosalicylate on oxygen affinity in normal, sickle and fetal human blood. | Sodium para-aminosalicylate (sodium salt of 2-hydroxy-4-aminobenzoic acid, Na-PAS) lowers the oxygen affinity of normal adult human placental, heterozygous and homozygous sickle cell anemic whole blood at 37 degrees C. The reduction of oxygen affinity is related to the type of hemoglobin in the blood. The mean P50 +/- ... | Effect of sodium para-aminosalicylate on oxygen affinity in normal, sickle and fetal human blood. Sodium para-aminosalicylate (sodium salt of 2-hydroxy-4-aminobenzoic acid, Na-PAS) lowers the oxygen affinity of normal adult human placental, heterozygous and homozygous sickle cell anemic whole blood at 37 degrees C. The... | [
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PMID:10432 | Drug blockade of open end-plate channels. | 1. The actions of amylobarbitone, thiopentone, methohexitone and methyprylone at voltage-clamped frog end-plates were studied. 2. In the presence of barbiturates the conductance change evoked by an iontophoretic carbachol application was reduced by a prepulse of carbachol. The extra inhibition evoked by a prepulse disa... | Drug blockade of open end-plate channels. 1. The actions of amylobarbitone, thiopentone, methohexitone and methyprylone at voltage-clamped frog end-plates were studied. 2. In the presence of barbiturates the conductance change evoked by an iontophoretic carbachol application was reduced by a prepulse of carbachol. The ... | [
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PMID:10433 | Conductances, diffusion and streaming potentials in the rat proximal tubule. | 1. Transtubular potential differences and specific resistances were measured in rat proximal tubules by means of single and double barrelled glass micro-electrodes. 2. Tip localization was made by observation of effective resistance changes measured with double barrelled micro-electrodes upon passage of oil droplets, a... | Conductances, diffusion and streaming potentials in the rat proximal tubule. 1. Transtubular potential differences and specific resistances were measured in rat proximal tubules by means of single and double barrelled glass micro-electrodes. 2. Tip localization was made by observation of effective resistance changes me... | [
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PMID:10434 | Some aspects of foetal and uteroplacental metabolism in cows with indwelling umbilical and uterine vascular catheters. | 1. The experiments were carried out on conscious pregnant Jersey cows with intravascular catheters implanted during late gestation in umbilical and uterine vessels. All but three of fifteen animals delivered live healthy calves. 2. Rountine daily analyses were made of blood gas tensions, pH and packed cell volume in fo... | Some aspects of foetal and uteroplacental metabolism in cows with indwelling umbilical and uterine vascular catheters. 1. The experiments were carried out on conscious pregnant Jersey cows with intravascular catheters implanted during late gestation in umbilical and uterine vessels. All but three of fifteen animals del... | [
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PMID:10435 | Stimulation-induced factors which affect augmentation and potentiation of trasmitter release at the neuromuscular junction. | 1. End-plate potentials (e.p.p.s) were recorded from frog sartorius neuromuscular junctions under conditions of decreased transmitter release to study the effect of repetitive stimulation on augmentation and potentiation of transmitter release. 2. The magnitudes and time constants of decay of augmentation and potentiat... | Stimulation-induced factors which affect augmentation and potentiation of trasmitter release at the neuromuscular junction. 1. End-plate potentials (e.p.p.s) were recorded from frog sartorius neuromuscular junctions under conditions of decreased transmitter release to study the effect of repetitive stimulation on augme... | [
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PMID:10436 | Gastric emptying of organic acids in the dog. | Test meals of 300 ml. of six different organic acids were instilled into the stomach of six healthy mongrel dogs. Citric, acetic, propionic, lactic, tartaric and succinic acid were given in 50, 100, 150, and 200 mN concentrations. 2. During the emptying process, the gastric contents were aspirated and immediately re-in... | Gastric emptying of organic acids in the dog. Test meals of 300 ml. of six different organic acids were instilled into the stomach of six healthy mongrel dogs. Citric, acetic, propionic, lactic, tartaric and succinic acid were given in 50, 100, 150, and 200 mN concentrations. 2. During the emptying process, the gastric... | [
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PMID:10439 | Evaluation of analgesic action and efficacy of antirheumatic drugs. Study of 10 drugs in 684 patients with rheumatoid arthritis. | A single-blind non-crossover method for assessing the potential effectiveness of antirheumatic drugs has been described. The method employs entirely subjective indices and incorporates a daily pain chart for measuring the pain response over the duration of the trial. In addition, the mean number of days withdrawn and p... | Evaluation of analgesic action and efficacy of antirheumatic drugs. Study of 10 drugs in 684 patients with rheumatoid arthritis. A single-blind non-crossover method for assessing the potential effectiveness of antirheumatic drugs has been described. The method employs entirely subjective indices and incorporates a dail... | [
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PMID:10441 | Sympathomimetic amines having a carbostyril nucleus. | A series of new sympathomimetic amines containing an 8-hydroxycarbostyril moiety was synthesized. These compounds probably exist as resonance hybrids having two acidic hydrogen atoms in locations approximating to those of the hydroxyl groups of catechol-containing adrenergic agents. In an in vitro test, many of these c... | Sympathomimetic amines having a carbostyril nucleus. A series of new sympathomimetic amines containing an 8-hydroxycarbostyril moiety was synthesized. These compounds probably exist as resonance hybrids having two acidic hydrogen atoms in locations approximating to those of the hydroxyl groups of catechol-containing ad... | [
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PMID:10444 | Fusion in phospholipid spherical membranes. II. Effect of cholesterol, divalent ions and pH. | Effect of cholesterol, divalent ions and pH on spherical bilayer membrane fusion was studied as a function of increasing temperature. Spherical bilayer membranes were composed of natural [phosphatidylcholine (PC) and phosphatidylserine (PS)] as well as synthetic (dipalmitoyl-PC, dimyristoyl-PC and dioleoyl-PC) phosphol... | Fusion in phospholipid spherical membranes. II. Effect of cholesterol, divalent ions and pH. Effect of cholesterol, divalent ions and pH on spherical bilayer membrane fusion was studied as a function of increasing temperature. Spherical bilayer membranes were composed of natural [phosphatidylcholine (PC) and phosphatid... | [
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PMID:10447 | Properties of two isolated antigens associated with bovine leukemia virus infection. | We isolated an ether-resistant internal antigen and an ether-sensitive antigen previously described in relation to bovine leukemia virus infection. These two antigens have now been isolated by isoelectric focusing and concanavalin A affinity chromatography, respectively. The ether-resistant antigen exhibited isoelectri... | Properties of two isolated antigens associated with bovine leukemia virus infection. We isolated an ether-resistant internal antigen and an ether-sensitive antigen previously described in relation to bovine leukemia virus infection. These two antigens have now been isolated by isoelectric focusing and concanavalin A af... | [
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PMID:10448 | Glutathione and gamma glutamyl transpeptidase in rat liver during chemical carcinogenesis. | Continued administration of several hepatocarcinogens led to an increase in the concentration of glutathione (GSH) in the livers of intact, but not of hypophysectomized or adrenalectomized rats. The concentration of GSH remained high untill the development of hyperplastic nodules. Subsequently, the concentration of GSH... | Glutathione and gamma glutamyl transpeptidase in rat liver during chemical carcinogenesis. Continued administration of several hepatocarcinogens led to an increase in the concentration of glutathione (GSH) in the livers of intact, but not of hypophysectomized or adrenalectomized rats. The concentration of GSH remained ... | [
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PMID:10449 | Cyclic nucleotides in the regulation of expression of differentiated functions in neuroblastoma cells. | Adenosine 3',5'-cyclic monophosphate (cAMP) may be one of the important factors in regulating the expression of many differentiated functions in neuroblastoma cells, but some of these functions can be induced by agents that do not increase the intracellular level of cAMP. An elevation of the intracellular level of guan... | Cyclic nucleotides in the regulation of expression of differentiated functions in neuroblastoma cells. Adenosine 3',5'-cyclic monophosphate (cAMP) may be one of the important factors in regulating the expression of many differentiated functions in neuroblastoma cells, but some of these functions can be induced by agent... | [
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PMID:10450 | Catecholamine metabolism in neuroblastoma. | Previous studies indicating the importance of catecholamine metabolism in neuroblastoma were briefly reviewed. Metabolic pathways were presented showing how the major urinary metabolites 3-methoxy-4-hydroxymandelic acid (VMA) and 3-methoxy-4-hydroxy-phenylacetic acid (HVA) are formed from norepinephrine and from dopami... | Catecholamine metabolism in neuroblastoma. Previous studies indicating the importance of catecholamine metabolism in neuroblastoma were briefly reviewed. Metabolic pathways were presented showing how the major urinary metabolites 3-methoxy-4-hydroxymandelic acid (VMA) and 3-methoxy-4-hydroxy-phenylacetic acid (HVA) are... | [
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PMID:10451 | Exonuclease associated with bacteriophage T5-Induced DNA polymerase. | T-5-induced DNA polymerase has been shown to possess a 3' leads to 5'-exonucleolytic activity. The exonuclease acts on both native and denatured DNA, but the apparent rate of degradation of denatured DNA is about five times faster than that for native DNA. The enzyme appears to act only on 3'-OH ends and produces mainl... | Exonuclease associated with bacteriophage T5-Induced DNA polymerase. T-5-induced DNA polymerase has been shown to possess a 3' leads to 5'-exonucleolytic activity. The exonuclease acts on both native and denatured DNA, but the apparent rate of degradation of denatured DNA is about five times faster than that for native... | [
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PMID:10452 | Structural proteins of polyoma virus: proteolytic degradation of virion proteins by exogenous and by virion-associated proteases. | A model has previously been proposed for the genetic relatedness of the structural proteins of polyoma virus, based upon similarities in the peptide maps of the major capsid protein VP1 with the virion proteins VP2 and VP3. Newer evidence suggests that this model is incorrect, and that protein VP1 is a product of one v... | Structural proteins of polyoma virus: proteolytic degradation of virion proteins by exogenous and by virion-associated proteases. A model has previously been proposed for the genetic relatedness of the structural proteins of polyoma virus, based upon similarities in the peptide maps of the major capsid protein VP1 with... | [
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PMID:10455 | Purification and properties of glucose-6-phosphate dehydrogenase from Bacillus subtilis spores. | Glucose-6-phosphate dehydrogenase [D-glucose-6-phosphate: NADP oxidoreductase, EC. 1. 1. 1. 49] obtained from spores of Bacillus subtilis PCI 219 strain was partially purified by filtration on Sephadex G-200, ammonium sulfate fractionation and chromatography on DEAE-Sephadex A-25 (about 54-fold). The optimum pH for sta... | Purification and properties of glucose-6-phosphate dehydrogenase from Bacillus subtilis spores. Glucose-6-phosphate dehydrogenase [D-glucose-6-phosphate: NADP oxidoreductase, EC. 1. 1. 1. 49] obtained from spores of Bacillus subtilis PCI 219 strain was partially purified by filtration on Sephadex G-200, ammonium sulfat... | [
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PMID:10456 | A new analgesic testing method using ultrasonic stimulation. I. Effects of narcotic and nonnarcotic analgesics. | A quantitative method for measuring pain threshold by the use of ultrasonic stimulation in mice has been designed. The method had the advantage of precision, simplicity of technique, rapidity of measurement, and the fact that the stimuli is innocuous upon repeated application. The nature of the senstaions induced by ul... | A new analgesic testing method using ultrasonic stimulation. I. Effects of narcotic and nonnarcotic analgesics. A quantitative method for measuring pain threshold by the use of ultrasonic stimulation in mice has been designed. The method had the advantage of precision, simplicity of technique, rapidity of measurement, ... | [
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PMID:10457 | Studies on the mode of antagonism between adrenergic beta-mimetics and beta-blocking agents (III). Functional antagonism between beta-mimetics and spasmogens. | New equations which can explain the following characteristic phenomena in the functional antagonism between isoproterenol (ISO) and spasmogens in guinea-pig trachea are proposed: (1) The amplitude of relaxation of the muscle induced by ISO varied depending on the concentration of a spasmogen used (histamine or carbacho... | Studies on the mode of antagonism between adrenergic beta-mimetics and beta-blocking agents (III). Functional antagonism between beta-mimetics and spasmogens. New equations which can explain the following characteristic phenomena in the functional antagonism between isoproterenol (ISO) and spasmogens in guinea-pig trac... | [
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PMID:10458 | Studies on the mode of antagonism between adrenergic beta-mimetics and beta-blocking agents (IV). Influence of functional antagonism by spasmogens. | A new theory is presented to describe the effect of functional antagonism on the competitive antagonism between adrenergic beta-mimetics and beta-blockers. According to this theory the shape of the log (dose ratio-1) vs.--log [B] curve and the apparent pA2 value in competitive antagonism should be affected by functiona... | Studies on the mode of antagonism between adrenergic beta-mimetics and beta-blocking agents (IV). Influence of functional antagonism by spasmogens. A new theory is presented to describe the effect of functional antagonism on the competitive antagonism between adrenergic beta-mimetics and beta-blockers. According to thi... | [
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PMID:10460 | HLA antigens in arterial occlusive diseases in Japan. | Using a NIH standard lymphocytotoxicity test, a possible Japanese specific HLA antigen, HLA-BJW 22.2 was identified in 17 out of 48 patients with thromboangiitis obliterans (35.4 per cent), in 5 out of 15 patients with Takayasu's arteritis (33.3 per cent) and in 11 out of 113 normal controls (9.7 per cent). On the othe... | HLA antigens in arterial occlusive diseases in Japan. Using a NIH standard lymphocytotoxicity test, a possible Japanese specific HLA antigen, HLA-BJW 22.2 was identified in 17 out of 48 patients with thromboangiitis obliterans (35.4 per cent), in 5 out of 15 patients with Takayasu's arteritis (33.3 per cent) and in 11 ... | [
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PMID:10463 | [Comparative evaluation of the clinical action of a series of beta-adrenergic blockaders]. | A comparative clinical study of the efficacy of Benzoral, Trasicor, Viskene, Aptene, Eraldine and Inderal was conducted in the ischaemic heart disease patients. Their antiarrhythmic and antianginal effect was determined, as well as their optimum therapeutic dosages, the activity of their specific beta-adrenolytic prope... | [Comparative evaluation of the clinical action of a series of beta-adrenergic blockaders]. A comparative clinical study of the efficacy of Benzoral, Trasicor, Viskene, Aptene, Eraldine and Inderal was conducted in the ischaemic heart disease patients. Their antiarrhythmic and antianginal effect was determined, as well ... | [
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PMID:10464 | [Change in the central and regional (brain) hemodynamics in the treatment of hypertension using beta-adrenergic blockaders]. | The haemodynamic parameters were studied dynamically by way of noninvasive techniques--tetrapolar thoracic rheography in the course of treatment of 48 patients with essential hypertension Stage IB and IIA urth beta-blocking agents Obsidan and Visken. It was found that as early as by the 5th day of therapy the stroke vo... | [Change in the central and regional (brain) hemodynamics in the treatment of hypertension using beta-adrenergic blockaders]. The haemodynamic parameters were studied dynamically by way of noninvasive techniques--tetrapolar thoracic rheography in the course of treatment of 48 patients with essential hypertension Stage I... | [
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PMID:10466 | [Assay of carbromal and its main metabolite (2-ethyl-butyryl-urea) in biological fluids (author's transl)]. | The materials mentioned above are reextracted from an ether solution by 2 N sodium hydroxide. The UV extinction of the aqueous layer at 232 nm and 30 degrees C is followed by means of a slave recorder. The original extinction is found by back-extrapolating to the time of re-extraction. It has to be corrected for the "b... | [Assay of carbromal and its main metabolite (2-ethyl-butyryl-urea) in biological fluids (author's transl)]. The materials mentioned above are reextracted from an ether solution by 2 N sodium hydroxide. The UV extinction of the aqueous layer at 232 nm and 30 degrees C is followed by means of a slave recorder. The origin... | [
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PMID:10467 | Histamine H2-receptor antagonists and gastric acid secretion -- a progress report. | Histamine H2-receptor antagonists, including burimamide, metiamide and cimetidine, are effective antagonists of histamine-stimulated acid secretion from mammalian, avian or reptilian gastric mucosa. Acid secretion stimulated by gastrin or pentagastrin is also inhibited by these drugs, but there is disagreement about th... | Histamine H2-receptor antagonists and gastric acid secretion -- a progress report. Histamine H2-receptor antagonists, including burimamide, metiamide and cimetidine, are effective antagonists of histamine-stimulated acid secretion from mammalian, avian or reptilian gastric mucosa. Acid secretion stimulated by gastrin o... | [
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PMID:10470 | [Selection of a urine preservative agent in relation to oxidative-catalytic methods of water regeneration]. | Various chemicals were assayed as possible urine conservers to the used in space water reclamation systems. With respect to the antimicrobial activity and the quality of reclaimed water formalin at a concentration of 0.1% was selected as the best conserver. The reagent ensures urine preservation for 3 months. | [Selection of a urine preservative agent in relation to oxidative-catalytic methods of water regeneration]. Various chemicals were assayed as possible urine conservers to the used in space water reclamation systems. With respect to the antimicrobial activity and the quality of reclaimed water formalin at a concentratio... | [
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PMID:10478 | [Hypoxia and polytrauma]. | The importance of polytrauma and hypoxia, resp., is discussed by the authors with regard to the mortality and the common effect of these is analysed. It was found that in the mortality of the patients suffered polytraumatism the first place (59,4%) is taken by such lesions, in which simultaneous lesion of the skull and... | [Hypoxia and polytrauma]. The importance of polytrauma and hypoxia, resp., is discussed by the authors with regard to the mortality and the common effect of these is analysed. It was found that in the mortality of the patients suffered polytraumatism the first place (59,4%) is taken by such lesions, in which simultaneo... | [
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PMID:10479 | [Classification and diagnosis of ankle injuries]. | A new method for the classification of the injuries of the ankle is recommended by the author. The main types according to his classifixation are the following: pronation-flexion, pronation-extension, supination-extension, supination-flexion and supination-extension types. His classification is compared with Lauge-Hans... | [Classification and diagnosis of ankle injuries]. A new method for the classification of the injuries of the ankle is recommended by the author. The main types according to his classifixation are the following: pronation-flexion, pronation-extension, supination-extension, supination-flexion and supination-extension typ... | [
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PMID:10480 | [The effect of ligament calcification following syndesmolysis on pseudoarthrosis of the median malleolus]. | The development of the false joint of the medial malleolus of 16 patients has been followed by the authors at the least for 13 years. It was found that in the cases, in which the fracture of the medial malleolus was concomitant with syndesmolysis, recovery of the false joint occured in the cases, in which in the place ... | [The effect of ligament calcification following syndesmolysis on pseudoarthrosis of the median malleolus]. The development of the false joint of the medial malleolus of 16 patients has been followed by the authors at the least for 13 years. It was found that in the cases, in which the fracture of the medial malleolus w... | [
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PMID:10481 | [Conservative and surgical treatment of open fractures of the forearm]. | On the basis of the 10 years' material of the Hugarian National Institute of Traumatology the possibilities of treatment of the open fractures of the forearm are discussed. It is stated by the authors that operative treatment of the open fractures of the forearm is more and more frequent, and--chiefly in the last time-... | [Conservative and surgical treatment of open fractures of the forearm]. On the basis of the 10 years' material of the Hugarian National Institute of Traumatology the possibilities of treatment of the open fractures of the forearm are discussed. It is stated by the authors that operative treatment of the open fractures ... | [
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PMID:10477 | Helix-coil stability constants for the naturally occurring amino acids in water. 11. Lysine parameters from random poly(hydroxybutylglutamine-co-L-lysine). | The synthesis and characterization of water-soluble random copolymers containing L-lysine with N5-(4-hydroxybutyl)-L-glutamine, and the thermally induced helix-coil transitions of these copolymers in water, are described. The incorporation of L-lysine was found to decrease the helix content of the polymers at neutral p... | Helix-coil stability constants for the naturally occurring amino acids in water. 11. Lysine parameters from random poly(hydroxybutylglutamine-co-L-lysine). The synthesis and characterization of water-soluble random copolymers containing L-lysine with N5-(4-hydroxybutyl)-L-glutamine, and the thermally induced helix-coil... | [
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PMID:10483 | [Substitution of the frontal bone with silicon]. | The good results obtained with silicon implants used in the frontal region are reported by the authors. After the correct primary treatment the reconstructive operations have been performed at the least 6 months after the lesion, if the environment of the defect was free from any reaction during this time. 14 implantat... | [Substitution of the frontal bone with silicon]. The good results obtained with silicon implants used in the frontal region are reported by the authors. After the correct primary treatment the reconstructive operations have been performed at the least 6 months after the lesion, if the environment of the defect was free... | [
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PMID:10484 | [Treatment of injuries of the penis and scrotum complicated by total skin loss]. | In connection with two healed cases the free transplantation of semi-thick skin is recommended by the authors for the treatment of the above-mentioned injuries, on the basis of the following reasons: 1. The most ideal results may be expected from this method. 2. The objective conditions (dermatome, Humbey's knife, spon... | [Treatment of injuries of the penis and scrotum complicated by total skin loss]. In connection with two healed cases the free transplantation of semi-thick skin is recommended by the authors for the treatment of the above-mentioned injuries, on the basis of the following reasons: 1. The most ideal results may be expect... | [
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PMID:10485 | [Acute arteria mesenterica superior syndrome caused by severe electric injury]. | The case of acute arteria mesenterica superior syndrome--occurred in a boy aged 10, as rare complication of high voltage electro-trauma--is reported. The aetiology of the syndrome, as well as a possible new pathogenic factor are discussed. The clinical picture and the therapeutic principles are dealt with. | [Acute arteria mesenterica superior syndrome caused by severe electric injury]. The case of acute arteria mesenterica superior syndrome--occurred in a boy aged 10, as rare complication of high voltage electro-trauma--is reported. The aetiology of the syndrome, as well as a possible new pathogenic factor are discussed. ... | [
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PMID:10486 | [Substitution of an injured finger joint by silicone rubber prosthesis]. | Between 1973 and the first semester of 1975, on the injured and destroyed digital articulation 27 patients have been operated on by means silicon rubber prosthesis of Swanson type. The prosthesis plasty and the field of its use are shortly resumed, pointing out the importance of its adaptation on the injured articulati... | [Substitution of an injured finger joint by silicone rubber prosthesis]. Between 1973 and the first semester of 1975, on the injured and destroyed digital articulation 27 patients have been operated on by means silicon rubber prosthesis of Swanson type. The prosthesis plasty and the field of its use are shortly resumed... | [
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PMID:10487 | [Phlebography of the talus following fracture and dislocation (preliminary report)]. | After dislocation or dislocated fracture of the talus late arthrosis is a frequent complication, in which primary bone and cartilage damage play a role. For the demonstration and preclusion, resp., of the vascular damage phlebography performed 3--6 months after the injury is recommended by the authors--by means of whic... | [Phlebography of the talus following fracture and dislocation (preliminary report)]. After dislocation or dislocated fracture of the talus late arthrosis is a frequent complication, in which primary bone and cartilage damage play a role. For the demonstration and preclusion, resp., of the vascular damage phlebography p... | [
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PMID:10490 | Pharmacotherapy of myocardial ischemia. | The cornerstones of pharmacotherapy for myocardial ischemia are the nitrites and the beta-adrenergic blocking agents. These drugs not only inhibit cardiac mechanical activity (and therefore energy requirements) in a variety of ways but also redistribute available blood flow to the potentially ischemic segments of cardi... | Pharmacotherapy of myocardial ischemia. The cornerstones of pharmacotherapy for myocardial ischemia are the nitrites and the beta-adrenergic blocking agents. These drugs not only inhibit cardiac mechanical activity (and therefore energy requirements) in a variety of ways but also redistribute available blood flow to th... | [
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PMID:10491 | Principles in selection of therapy. | The physician today is presented with a plethora of possibilities in the therapy of each of the aspects of ischemic heart disease (Fig. 15-5). There is the temptation to recommend complex and impossible dietary prescriptions coupled with several pharmaceutical agents for control of anginal pain, hypertension, arrhythmi... | Principles in selection of therapy. The physician today is presented with a plethora of possibilities in the therapy of each of the aspects of ischemic heart disease (Fig. 15-5). There is the temptation to recommend complex and impossible dietary prescriptions coupled with several pharmaceutical agents for control of a... | [
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PMID:10504 | Triacetylated insulin: biologic activity and resistance to degradation. | Tritiated N-hydroxysuccinimide acetate was prepared with specific activities up to 5 Ci/mmole and utilized to prepare tritiated triacetyl insulin. Binding of triacetyl insulin to liver plasma membranes was measured by its capacity to displace 125I-monoiodoinsulin. At low concentrations, less than 10 ng/ml triacetyl ins... | Triacetylated insulin: biologic activity and resistance to degradation. Tritiated N-hydroxysuccinimide acetate was prepared with specific activities up to 5 Ci/mmole and utilized to prepare tritiated triacetyl insulin. Binding of triacetyl insulin to liver plasma membranes was measured by its capacity to displace 125I-... | [
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PMID:10505 | Effects of arginine infusion in infants: increased urea synthesis associated with unchanged ammonia blood levels. | Infusion of L-arginine hydrochloride in infants and children (ages ranging from 1 day to 12 yr) at a dosage of 0.5 g/kg body weight resulted in a dramatic increase in the arginine plasma concentration, with highest values of approximately 7 mmole/liter immediately after the end of the infusion; 120 min later the mean p... | Effects of arginine infusion in infants: increased urea synthesis associated with unchanged ammonia blood levels. Infusion of L-arginine hydrochloride in infants and children (ages ranging from 1 day to 12 yr) at a dosage of 0.5 g/kg body weight resulted in a dramatic increase in the arginine plasma concentration, with... | [
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PMID:10506 | Effect of hydrogen ion buffers on photosynthetic oxygen evolution in the blue-green alga, Agmenellum quadruplicatum. | The photosynthetic oxygen evolution capacity of Agmenelium quadruplication suspended in four hydrogen ion buffers (pH 7.4, 0.05 M) and its synthetic marine growth medium was measured with an oxygen electrode. High rates of oxygen evolution were obtained in the growth medium and N-tris(hydroxymethyl)-methylglycine (Tric... | Effect of hydrogen ion buffers on photosynthetic oxygen evolution in the blue-green alga, Agmenellum quadruplicatum. The photosynthetic oxygen evolution capacity of Agmenelium quadruplication suspended in four hydrogen ion buffers (pH 7.4, 0.05 M) and its synthetic marine growth medium was measured with an oxygen elect... | [
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PMID:10508 | A new form of antihistamine--the H2-receptor antagonist. | A new group of drugs, the histamine2 (H2)-receptor antagonists, act on receptors in the stomach to reduce acid secretion when this is stimulated by histamine, pentagastrin, the vagus nerve or food. The reduction in acid secretion is profound and may approach the degree of reduction brought about by gastric surgery. The... | A new form of antihistamine--the H2-receptor antagonist. A new group of drugs, the histamine2 (H2)-receptor antagonists, act on receptors in the stomach to reduce acid secretion when this is stimulated by histamine, pentagastrin, the vagus nerve or food. The reduction in acid secretion is profound and may approach the ... | [
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PMID:10509 | Streptococcal sore throat in general practice--a controlled study. | A controlled study was undertaken to determine the incidence of Group A haemolytic streptococci and other bacterial pathogens in throat swabs from patients presenting with sore throats. The isolation rate (38-8%) of Group A haemolytic streptococci from patients with acute tonsillitis was significantly higher than the i... | Streptococcal sore throat in general practice--a controlled study. A controlled study was undertaken to determine the incidence of Group A haemolytic streptococci and other bacterial pathogens in throat swabs from patients presenting with sore throats. The isolation rate (38-8%) of Group A haemolytic streptococci from ... | [
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PMID:10527 | Reflex increase in coronary vascular resistance in patients with ischemic heart disease. | To assess possible coronary vasoconstriction in patients with ischemic heart disease, we measured coronary vascular resistance in 12 patients with normal hearts and 12 with coronary disease before and during the initial 50 seconds of cold pressor test, a stimulus known to produce systemic vasoconstriction. Control coro... | Reflex increase in coronary vascular resistance in patients with ischemic heart disease. To assess possible coronary vasoconstriction in patients with ischemic heart disease, we measured coronary vascular resistance in 12 patients with normal hearts and 12 with coronary disease before and during the initial 50 seconds ... | [
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PMID:10531 | Proteolytic activity in liver cells from mouse, rat, Ehrlich ascites carcinoma bearing mouse and in Ehrlich ascites carcinoma cells. | The activity of intracellular proteinases from Ehrlich ascites carcinoma bearing mice were compared with that from liver cells of normal mice and rats. The activity of intracellular proteinases was measured in the supernatant of Ehrlich ascites carcinoma cells homogenate. The activity of intracellular proteinases in no... | Proteolytic activity in liver cells from mouse, rat, Ehrlich ascites carcinoma bearing mouse and in Ehrlich ascites carcinoma cells. The activity of intracellular proteinases from Ehrlich ascites carcinoma bearing mice were compared with that from liver cells of normal mice and rats. The activity of intracellular prote... | [
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PMID:10538 | Correlation of the oxytocin challenge test with perinatal outcome. | A total of 234 oxytocin challenge tests (OCT) were performed on 100 high-risk patients. The results were negative (N) in 68 of these 100 patients, suspicious (S) in 22, and positive (P) in 10. The incidence of late decelerations during labor was N, 5%; S, 40%; P, 86%; and meconium staining of the amniotic fluid was N, ... | Correlation of the oxytocin challenge test with perinatal outcome. A total of 234 oxytocin challenge tests (OCT) were performed on 100 high-risk patients. The results were negative (N) in 68 of these 100 patients, suspicious (S) in 22, and positive (P) in 10. The incidence of late decelerations during labor was N, 5%; ... | [
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PMID:10539 | Microstructure of the solder-casting zone in bridges of dental gold alloys. | The composition and structure were studied in the cast and in the solder of bridges which had failed clinically. Both materials were gold alloys but with different contents of Pt, Ag and Zn. The metallographic investigation revealed defects mostly in the solder, situated in the subsurface layer. SEM studied of the frac... | Microstructure of the solder-casting zone in bridges of dental gold alloys. The composition and structure were studied in the cast and in the solder of bridges which had failed clinically. Both materials were gold alloys but with different contents of Pt, Ag and Zn. The metallographic investigation revealed defects mos... | [
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PMID:10541 | Gingival crevicular fluid: a new diagnostic aid in managing the periodontal patient. | On the whole, the studies on GCF have demonstrated that the flow of this fluid is sufficiently indicative of the inflammatory state that it can be used under a variety of clinical conditions to monitor and control gingival inflammation. Since gingivitis is extremely common, and since some cases of gingivitis presumably... | Gingival crevicular fluid: a new diagnostic aid in managing the periodontal patient. On the whole, the studies on GCF have demonstrated that the flow of this fluid is sufficiently indicative of the inflammatory state that it can be used under a variety of clinical conditions to monitor and control gingival inflammation... | [
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PMID:10544 | [Neuroaminergic control of anterior pituitary secretions (author's transl)]. | The demonstration and identification of monoamines and of aminergic tracts in the central nervous system has permitted a study of their role in the control of the liberation of hypothalamic releasing hormones. Knowledge of the role of these hypothalamic neurohormones in the release of pituitary hormones is at present u... | [Neuroaminergic control of anterior pituitary secretions (author's transl)]. The demonstration and identification of monoamines and of aminergic tracts in the central nervous system has permitted a study of their role in the control of the liberation of hypothalamic releasing hormones. Knowledge of the role of these hy... | [
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PMID:10545 | Diagnosis and treatment of duodenal ulcer in infancy and childhood. | An awareness of the modes of presentation in childhood duodenal ulcer disease is necessary for prompt diagnosis and treatment. Therapy should be based on the rationale of decreasing acid secretion and providing adequate buffering of gastric acid throughout the day. Because of the high incidence of recurrence in childre... | Diagnosis and treatment of duodenal ulcer in infancy and childhood. An awareness of the modes of presentation in childhood duodenal ulcer disease is necessary for prompt diagnosis and treatment. Therapy should be based on the rationale of decreasing acid secretion and providing adequate buffering of gastric acid throug... | [
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PMID:10546 | Genetic variation of lysosomal acid lipase. | Lysosomal acid lipase (LAL) activity was measured using a new fluorometric assay in cultured skin fibroblasts from eight control subjects, two obligate heterozygotes for Wolman's disease (WD), one patient with WD, and one patient with cholesteryl ester storage disease (CESD). The LAL activities (mean+/-SD) were 25.8+/-... | Genetic variation of lysosomal acid lipase. Lysosomal acid lipase (LAL) activity was measured using a new fluorometric assay in cultured skin fibroblasts from eight control subjects, two obligate heterozygotes for Wolman's disease (WD), one patient with WD, and one patient with cholesteryl ester storage disease (CESD).... | [
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PMID:10549 | Influence of low extracellular pH upon the Ca inward current and isometric contractile force in mammalian ventricular myocardium. | In isolated papillary muscles of cats the changes in Ca inward current and isometric contractile force following a decrease of extracellular pH from 7.4 to 5.5 were studied. The Ca current was analyzed (a) by measuring the upstroke velocity of Ca-mediated action potentials and (b) in voltage clamp experiments using the... | Influence of low extracellular pH upon the Ca inward current and isometric contractile force in mammalian ventricular myocardium. In isolated papillary muscles of cats the changes in Ca inward current and isometric contractile force following a decrease of extracellular pH from 7.4 to 5.5 were studied. The Ca current w... | [
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PMID:10550 | [Acute kidney failure during periarteritis nodosa]. | In 9 patients aged 16 to 71 years with acute renal failure, histological examination disclosed polyarteritis nodosa. Symptoms of rapidly progressive glomerulonephritis (GN) were present in 7 cases. Hypertension was a constant feature. Fever and muscular articular and cutaneous signs occured at times simulating Henoch-S... | [Acute kidney failure during periarteritis nodosa]. In 9 patients aged 16 to 71 years with acute renal failure, histological examination disclosed polyarteritis nodosa. Symptoms of rapidly progressive glomerulonephritis (GN) were present in 7 cases. Hypertension was a constant feature. Fever and muscular articular and ... | [
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PMID:10562 | Treatment of angina pectoris. Pharmacologic approaches. | The short-acting nitrite sublingual nitroglycerin is the cornerstone of drug treatment of angina pectoris. It is most useful when given two to three minutes before activity that may precipitate an anginal attack. If disabling angina persists despite medical management and there is no contraindication, the beta-adrenerg... | Treatment of angina pectoris. Pharmacologic approaches. The short-acting nitrite sublingual nitroglycerin is the cornerstone of drug treatment of angina pectoris. It is most useful when given two to three minutes before activity that may precipitate an anginal attack. If disabling angina persists despite medical manage... | [
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PMID:10564 | An eighteen months' study of the clinical response to metoprolol, a selective beta1-receptor blocking agent, in patients with angina pectoris. | Following an initial dose response study, metoprolol, a selective beta1-receptor blocking agent, was compared with equipotent dosages of propanolol in a double blind cross-over study, including exercise tolerance tests, on fourteen patients with angina pectoris. Long term therapy with metoprolol then followed until the... | An eighteen months' study of the clinical response to metoprolol, a selective beta1-receptor blocking agent, in patients with angina pectoris. Following an initial dose response study, metoprolol, a selective beta1-receptor blocking agent, was compared with equipotent dosages of propanolol in a double blind cross-over ... | [
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PMID:10560 | Piperazine derivatives of dimethylxanthines. IV. Reaction of beta,gamma-epoxypropyldimethylxanthines with piperazines. | In the reaction of 7-resp. 1-beta,gamma-epoxyproplderivatives of theophylline (Th) or theobromine (Tb) with piperazine and N-monoalkyl or monoarylpiperazines the corresponding 7-resp. 1-beta-hydroxy-gamma-piperazinopropyl-Th (1-8) resp. Tb (9-16) were formed. In preliminary screening some of the new compounds showed st... | Piperazine derivatives of dimethylxanthines. IV. Reaction of beta,gamma-epoxypropyldimethylxanthines with piperazines. In the reaction of 7-resp. 1-beta,gamma-epoxyproplderivatives of theophylline (Th) or theobromine (Tb) with piperazine and N-monoalkyl or monoarylpiperazines the corresponding 7-resp. 1-beta-hydroxy-ga... | [
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PMID:10565 | Pneumococcal antigen in pneumonia. A post-mortem study with the histological and bacteriological findings. | Pneumococcal capsular antigens can be detected in lung tissue by counter-current immunoelectrophoresis even when, following antibiotics, post-mortem bacterilogy suggests that Escherichia coli has replaced pneumococci. The results suggest that antipneumococcal therapy would benefit at least 55% of patients critically il... | Pneumococcal antigen in pneumonia. A post-mortem study with the histological and bacteriological findings. Pneumococcal capsular antigens can be detected in lung tissue by counter-current immunoelectrophoresis even when, following antibiotics, post-mortem bacterilogy suggests that Escherichia coli has replaced pneumoco... | [
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PMID:10561 | The stability of N-pyrrolidinomethyltetracycline in solutions. | In aqueous solution N-pyrrolidinomethyltetracycline (PTC) undergoes decomposition into tetracycline, epitetracylcine, anhydroepitetracycline and ynhydrotetracycline. The decomposition products were identified and separated by TLC and their activity was estimated microbiologically. | The stability of N-pyrrolidinomethyltetracycline in solutions. In aqueous solution N-pyrrolidinomethyltetracycline (PTC) undergoes decomposition into tetracycline, epitetracylcine, anhydroepitetracycline and ynhydrotetracycline. The decomposition products were identified and separated by TLC and their activity was est... | [
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PMID:10570 | Catecholamine-stimulated cyclic GMP accumulation in the rat pineal: apparent presynaptic site of action. | Guanosine 3':5'-cyclic monophosphate (cGMP) increased 7-fold in rat pineal glands incubated in the presence of l-norepinephrine. This response consisted of two components-one was stereospecific and inhibited by alpha-adrenergic antagonists while the other was not stereospecific and not readily inhibited by antagonists.... | Catecholamine-stimulated cyclic GMP accumulation in the rat pineal: apparent presynaptic site of action. Guanosine 3':5'-cyclic monophosphate (cGMP) increased 7-fold in rat pineal glands incubated in the presence of l-norepinephrine. This response consisted of two components-one was stereospecific and inhibited by alph... | [
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PMID:10571 | Erythrocyte membranes undergo cooperative, pH-sensitive state transitions in the physiological temperature range: evidence from Raman spectroscopy. | We have examined the Raman scattering from erythrocyte ghosts at 2700 to 3000 cm-1 (CH-stretching region). Plots of the intensity (I) of the 2930 cm-1 band relative to the intensity of the thermally stable 2850 cm-1 band, i.e., the [I2930/I2850] ratio, as a function of temperature reveal a sharp discontinuity, which at... | Erythrocyte membranes undergo cooperative, pH-sensitive state transitions in the physiological temperature range: evidence from Raman spectroscopy. We have examined the Raman scattering from erythrocyte ghosts at 2700 to 3000 cm-1 (CH-stretching region). Plots of the intensity (I) of the 2930 cm-1 band relative to the ... | [
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PMID:10572 | Central regulation of sympathetic neuron development. | The sixth lumbar (L-6) ganglion has been used to study the central regulation of peripheral sympathetic neuron development. During post-natal ontogeny, tyrosine hydroxylase [tyrosine 3-monooxygenase, L-tyrosine, tetrahydropteridine: oxygen oxidoreductase (3-hydroxylating), EC 1.14.16.2] activity increased 60-fold, whil... | Central regulation of sympathetic neuron development. The sixth lumbar (L-6) ganglion has been used to study the central regulation of peripheral sympathetic neuron development. During post-natal ontogeny, tyrosine hydroxylase [tyrosine 3-monooxygenase, L-tyrosine, tetrahydropteridine: oxygen oxidoreductase (3-hydroxyl... | [
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PMID:10569 | [Purification and properties of L-glutamine and L-asparagine deaminase from Pseudomonas aurantiaca IBPM-14]. | An enzymic preparation of L-glutamine and L-asparagine deamidase was obtained from Pseudomonas auractiaca IBPM B-14. The preparation was purified 100--150-fold by thermal treatment and chromotography on columns with biogel P-150 and DEAE-cellulose. The enzymic activity was measured by the methods of hydroxylaminolysis ... | [Purification and properties of L-glutamine and L-asparagine deaminase from Pseudomonas aurantiaca IBPM-14]. An enzymic preparation of L-glutamine and L-asparagine deamidase was obtained from Pseudomonas auractiaca IBPM B-14. The preparation was purified 100--150-fold by thermal treatment and chromotography on columns ... | [
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PMID:10573 | Use of thyrotropin and cholera toxin to probe the mechanism by which interferon initiates its antiviral activity. | Thyrotropin (10 muM) inhibited the antiviral activity of interferon. When added after interferon, thyrotropin (TSH) had no effect on antiviral activity. There was also no inhibition of interferon action in cells washed with medium between incubations with TSH and interferon. 125I-Labeled TSH and 125I-labeled cholera to... | Use of thyrotropin and cholera toxin to probe the mechanism by which interferon initiates its antiviral activity. Thyrotropin (10 muM) inhibited the antiviral activity of interferon. When added after interferon, thyrotropin (TSH) had no effect on antiviral activity. There was also no inhibition of interferon action in ... | [
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PMID:10574 | Multiple factor analysis of the action of local anesthetics. | The pH jump data of Bianchi and Strobel [(1968) Trans. N.Y. Acad. Sci. Ser. II, 30, 1082-1092] on desheathed frog sciatic nerve are fitted to rate equations. A general quantitation of synergism, summation, and antagonism of anesthetics and of excitation is given. | Multiple factor analysis of the action of local anesthetics. The pH jump data of Bianchi and Strobel [(1968) Trans. N.Y. Acad. Sci. Ser. II, 30, 1082-1092] on desheathed frog sciatic nerve are fitted to rate equations. A general quantitation of synergism, summation, and antagonism of anesthetics and of excitation is gi... | [
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PMID:10575 | Rumen function in red deer, hill sheep and reindeer in the scottish highlands. | Red deer, sheep and reindeer grazing on their normal hill ranges were examined at intervals over a period of four years. Samples from the digestive tract were taken at different seasons and processed in the field. The Red deer and reindeer were killed before samples were taken; rumen samples from the sheep were taken b... | Rumen function in red deer, hill sheep and reindeer in the scottish highlands. Red deer, sheep and reindeer grazing on their normal hill ranges were examined at intervals over a period of four years. Samples from the digestive tract were taken at different seasons and processed in the field. The Red deer and reindeer w... | [
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PMID:10577 | Modulation of cycloheximide-resistant memory by sympathomimetic agents. | Amphetamine overcomes the amnesia caused by cycloheximide (CXM) provided it is administered closely following the learning trial. In day-old chickens with one trial passive avoidance learning, there is a short-term, labile memory existing for 90 min following training under the influence of CXM. Amphetamine has been sh... | Modulation of cycloheximide-resistant memory by sympathomimetic agents. Amphetamine overcomes the amnesia caused by cycloheximide (CXM) provided it is administered closely following the learning trial. In day-old chickens with one trial passive avoidance learning, there is a short-term, labile memory existing for 90 mi... | [
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PMID:10578 | Studies on the polymorphism of carbromal. | Specimens of carbromal obtained by crystallization from various solvents were analyzed. After a 9-month storage period, the occurrence of three polymorphic forms (I, II and III) was ascertained. The metastable form III obtained by crystallization from dimethylformamide showed a reasonably high stability. Preliminary ph... | Studies on the polymorphism of carbromal. Specimens of carbromal obtained by crystallization from various solvents were analyzed. After a 9-month storage period, the occurrence of three polymorphic forms (I, II and III) was ascertained. The metastable form III obtained by crystallization from dimethylformamide showed a... | [
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PMID:10583 | Treatment of depression with tricyclic drugs--pharmacokinetic and pharmacodynamic aspects. | A series of studies on the pharmacokinetic and pharmacodynamic properties of some tricyclic antidepressants is reviewed. During treatment with the same oral dose of these drugs, patients develop widely differing plasma levels. The importance of this variability for the clinical effects has been studied in detail for th... | Treatment of depression with tricyclic drugs--pharmacokinetic and pharmacodynamic aspects. A series of studies on the pharmacokinetic and pharmacodynamic properties of some tricyclic antidepressants is reviewed. During treatment with the same oral dose of these drugs, patients develop widely differing plasma levels. Th... | [
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0.06606798... |
PMID:10584 | The contribution of drug research to investigating the nature of endogenous depression. | A relationship between brain monamines and endogenous depression is suggested by observations on the mode of action of drugs producing or alleviating depressive symptoms. For example, reserpine is capable of faithfully mimicking the clinical picture of endogenous depression, which may be related to monoamine depletion.... | The contribution of drug research to investigating the nature of endogenous depression. A relationship between brain monamines and endogenous depression is suggested by observations on the mode of action of drugs producing or alleviating depressive symptoms. For example, reserpine is capable of faithfully mimicking the... | [
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PMID:10585 | Indications for long-term pharmacological treatment of schizophrenic syndromes. | The practice of long term pharmacological treatment of schizophrenic syndromes has become widespread and seems to be currently recommended. The concept appears, however, to be poorly defined, and the assumptions underlying this therapeutic approach are scarcely discussed. In the present paper possible differences as co... | Indications for long-term pharmacological treatment of schizophrenic syndromes. The practice of long term pharmacological treatment of schizophrenic syndromes has become widespread and seems to be currently recommended. The concept appears, however, to be poorly defined, and the assumptions underlying this therapeutic ... | [
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PMID:10586 | Critical study of the use of long acting neuroleptics (depot neuroleptics) in France. | Long acting neuroleptics (L.A.N.) represent 11% of the medical prescription of neuroleptics in France (about 40,000 patients in 1974). Some psychiatrists remain reluctant to prescribe long acting-neuroleptics and many problems related to their use are still solved empirically:1) relation between the posology of the sta... | Critical study of the use of long acting neuroleptics (depot neuroleptics) in France. Long acting neuroleptics (L.A.N.) represent 11% of the medical prescription of neuroleptics in France (about 40,000 patients in 1974). Some psychiatrists remain reluctant to prescribe long acting-neuroleptics and many problems related... | [
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0.... |
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