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PMID:13654 | Studies of glucose turnover and renal function in an unusual case of hereditary fructose intolerance. | Examination of glucose kinetics, pancreatic alpha and beta cell function, plasma lipids, urinary acidification and calcium excretion has been undertaken in a patient with hereditary fructose intolerance. This case was unusual as it was associated with insulin-requiring diabetes, type IV hyperlipemia, hypercalciuria and... | Studies of glucose turnover and renal function in an unusual case of hereditary fructose intolerance. Examination of glucose kinetics, pancreatic alpha and beta cell function, plasma lipids, urinary acidification and calcium excretion has been undertaken in a patient with hereditary fructose intolerance. This case was ... | [
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PMID:13656 | Evaluation of success in treatment of threatening premature labor by betamimetic drugs. | For prevention of premature labor the betasympathicomimetic drugs buphenin, fenoterol, and ritodrine were administered to 135 patients intravenously for 1 week and afterward orally up to the end of week 37 of gestation. No satisfactory evaluation of success could be obtained by analyzing only the time gained by the tre... | Evaluation of success in treatment of threatening premature labor by betamimetic drugs. For prevention of premature labor the betasympathicomimetic drugs buphenin, fenoterol, and ritodrine were administered to 135 patients intravenously for 1 week and afterward orally up to the end of week 37 of gestation. No satisfact... | [
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PMID:13657 | Fetal breathing and adaptation to maternal hemorrhage in the sheep. | The effect of maternal hemorrhage in chronic preparations was studied on fetal lambs in the last month of gestation. Fourteen to 20 per cent of maternal blood was estimated to have been removed within 30 minutes, which resulted in a drop of 30 per cent of mean maternal arterial pressure. A fetal bradycardia started 28 ... | Fetal breathing and adaptation to maternal hemorrhage in the sheep. The effect of maternal hemorrhage in chronic preparations was studied on fetal lambs in the last month of gestation. Fourteen to 20 per cent of maternal blood was estimated to have been removed within 30 minutes, which resulted in a drop of 30 per cent... | [
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PMID:13658 | Secretory surface area and phosphatase activity of frog gastric mucosa. | Gastric mucosae were isolated from the European frog, R. temporaria, and after 5-7 h, stimulated with histamine (10(-4) M) and theophylline (5 mM). Acid secretion increased about fourfold, and this was accompanied by a threefold increase in secretory surface of the oxyntic cells, as determined in electron micrographs w... | Secretory surface area and phosphatase activity of frog gastric mucosa. Gastric mucosae were isolated from the European frog, R. temporaria, and after 5-7 h, stimulated with histamine (10(-4) M) and theophylline (5 mM). Acid secretion increased about fourfold, and this was accompanied by a threefold increase in secreto... | [
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PMID:13659 | HCO3 transport in rat jejunum: relationship to NaCl and H2O transport in vivo. | HCO3- absorption and its association with Na+ absorption has been studied in the rat jejunum in vivo, using a single-pass perfusion technique. The method of disequilibrium pH, the only valid way of demonstrating jejunal H+ secretion, was used to distinguish between an HCO3- pump and H+ secretion as the mechanism of HCO... | HCO3 transport in rat jejunum: relationship to NaCl and H2O transport in vivo. HCO3- absorption and its association with Na+ absorption has been studied in the rat jejunum in vivo, using a single-pass perfusion technique. The method of disequilibrium pH, the only valid way of demonstrating jejunal H+ secretion, was use... | [
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PMID:13660 | Vitamin K1 intestinal absorption in vivo: influence of luminal contents on transport. | Intestinal absorption of [3H]phylloquinone was investigated in the unanesthetized rat by the use of a technique of recirculating perfused isolated intestinal segments. Apparent saturation kinetics were found as the concentration of the vitamin in the perfusate was increased in a stepwise fashion from 15 nM to 300 muM. ... | Vitamin K1 intestinal absorption in vivo: influence of luminal contents on transport. Intestinal absorption of [3H]phylloquinone was investigated in the unanesthetized rat by the use of a technique of recirculating perfused isolated intestinal segments. Apparent saturation kinetics were found as the concentration of th... | [
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PMID:13661 | Fluoride absorption from the rat urinary bladder: a pH-dependent event. | Urinary bladder absorption of stable and radiofluoride was studied as a function of pH in anesthetized rats to further evaluate the influence of pH gradients on fluoride transport. Buffered pH values and stable fluoride concentrations ranged from 1.85 to 7.90 and from 0.012 to 8.81 mM, respectively. [14c]inulin served ... | Fluoride absorption from the rat urinary bladder: a pH-dependent event. Urinary bladder absorption of stable and radiofluoride was studied as a function of pH in anesthetized rats to further evaluate the influence of pH gradients on fluoride transport. Buffered pH values and stable fluoride concentrations ranged from 1... | [
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PMID:13662 | Effect of autonomic blockade on the hemodynamic findings in acute cardiac tamponade. | Twenty-three closed-chest, alpha-chloralose-anesthetized, volume-expanded, alpha- and beta-adrenergic-blockaded dogs with rate fixed by atrial pacing had 30-90 ml of saline at 37 degrees C infused into the pericardial sac a) with vagus intact, b) after vagotomy, and c) with vagus intact but with systolic pressure augme... | Effect of autonomic blockade on the hemodynamic findings in acute cardiac tamponade. Twenty-three closed-chest, alpha-chloralose-anesthetized, volume-expanded, alpha- and beta-adrenergic-blockaded dogs with rate fixed by atrial pacing had 30-90 ml of saline at 37 degrees C infused into the pericardial sac a) with vagus... | [
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PMID:13663 | Action of histamine and H1 and H2 blockers on the cardiopulmonary circulation. | Systemic and pulmonary hemodynamic responses to histamine were investigated inchronically instrumented unanesthetized nonpregnant ewes. Histamine was administered intravenously and into the pulmonary artery. The effects of the same doses of histamine were assessed following H1 and H2 receptor blockade. The effects ocul... | Action of histamine and H1 and H2 blockers on the cardiopulmonary circulation. Systemic and pulmonary hemodynamic responses to histamine were investigated inchronically instrumented unanesthetized nonpregnant ewes. Histamine was administered intravenously and into the pulmonary artery. The effects of the same doses of ... | [
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PMID:13664 | Physiologic effects of normal-or low-oxygen-affinity red cells in hypoxic baboons. | Baboons were bled one-third their red cell mass and were given homologous transfusions of red blood cells to restore the red cell volume. One group of baboons received red blood cells with a normal 2,3-diphosphoglycerate 2,3-DPG) level and normal affinity for oxygen, and in this group the 2,3-DPG level after transfusio... | Physiologic effects of normal-or low-oxygen-affinity red cells in hypoxic baboons. Baboons were bled one-third their red cell mass and were given homologous transfusions of red blood cells to restore the red cell volume. One group of baboons received red blood cells with a normal 2,3-diphosphoglycerate 2,3-DPG) level a... | [
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PMID:13665 | Acid-base balance and plasma composition in the aestivating lungfish (Protopterus). | Upon entering into aestivation, Protopterus aethiopicus develops a respiratory acidosis. A slow compensatory increase in plasma bicarbonate suffices only to partially restore arterial pH toward normal. The cessation of water intake from the start of aestivation results in hemoconcentration and marked oliguria. The conc... | Acid-base balance and plasma composition in the aestivating lungfish (Protopterus). Upon entering into aestivation, Protopterus aethiopicus develops a respiratory acidosis. A slow compensatory increase in plasma bicarbonate suffices only to partially restore arterial pH toward normal. The cessation of water intake from... | [
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PMID:13668 | Secretory state of gastric mucosa and resistance to injury by exogenous acid. | The capacity of the stomach to resist the effects of highly acid solutions was assessed by comparing the effects of such solutions on spontaneously secreting, stimulated, and inhibited gastric mucosae of rabbits in vivo and frogs in vitro. Exposure of unstimulated resting mucosa to HC1, 120 mM, for 60 minutes produced ... | Secretory state of gastric mucosa and resistance to injury by exogenous acid. The capacity of the stomach to resist the effects of highly acid solutions was assessed by comparing the effects of such solutions on spontaneously secreting, stimulated, and inhibited gastric mucosae of rabbits in vivo and frogs in vitro. Ex... | [
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PMID:13669 | Effects of chronic hypoxia on canine gastric secretion. | Interdigestive gastirc acid output and acid secretory response to histamine, insulin and pentagastrin were studied in five dogs before and after creation of a right to left extracardiac vascular shunt. The arterial PO2 decreased from 81.5 +/- 5.5 mm Hg to 39.8 +/- 6.0 mm Hg postoperatively with no change in arterial p... | Effects of chronic hypoxia on canine gastric secretion. Interdigestive gastirc acid output and acid secretory response to histamine, insulin and pentagastrin were studied in five dogs before and after creation of a right to left extracardiac vascular shunt. The arterial PO2 decreased from 81.5 +/- 5.5 mm Hg to 39.8 +/... | [
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PMID:13673 | The redox state of the glutathione in the bovine corneal epithelium. | In the corneal epithelium the levels of the oxidized and reduced glutathione, the oxidized and reduced triphosphopyridine nucleotide, the glucose-6-phosphate and the 6-phosphogluconate were investigated. The in vivo steady state levels were defined by preparation procedures and by the energy state of the adenosine phos... | The redox state of the glutathione in the bovine corneal epithelium. In the corneal epithelium the levels of the oxidized and reduced glutathione, the oxidized and reduced triphosphopyridine nucleotide, the glucose-6-phosphate and the 6-phosphogluconate were investigated. The in vivo steady state levels were defined by... | [
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PMID:13677 | Acid-base balance and blood gases changes and "lactate excess" in acute respiratory alkalosis during general anaesthesia. | In 40 young males aged 18-20 years operated on for inguinal hernioplasty acute respiratory alkalosis was obtained in the 45th minute of general anaesthesia. The values of basic acid-base balance parameters, blood gases, pyruvate and lactate levels and "lactate excess" were determined before and after hyperventilation. ... | Acid-base balance and blood gases changes and "lactate excess" in acute respiratory alkalosis during general anaesthesia. In 40 young males aged 18-20 years operated on for inguinal hernioplasty acute respiratory alkalosis was obtained in the 45th minute of general anaesthesia. The values of basic acid-base balance par... | [
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PMID:13678 | The effect of adrenergic receptor blocking agents on arrhythmia caused by trauma. | Experiments on animals have shown that blunt trauma to the anterior chest wall causes arrhythmia and conduction disturbances. In most cases nodal rhythm and ST segment elevation were observed. Microscopic examination disclosed myocardial damage in the vicinity of the atrioventricular node. Administration of alpha or be... | The effect of adrenergic receptor blocking agents on arrhythmia caused by trauma. Experiments on animals have shown that blunt trauma to the anterior chest wall causes arrhythmia and conduction disturbances. In most cases nodal rhythm and ST segment elevation were observed. Microscopic examination disclosed myocardial ... | [
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PMID:13682 | General anesthetics and regional hypoxic pulmonary vasoconstriction. | Administration of N2O, fluroxene and isoflurane to the left lower lobe (LLL) of dogs anesthetized with pentobarbital was previously shown to inhibit LLL hypoxic pulmonary vasoconstriction (HPV). Using the same experimental model, the present study examined the effect of whole-lung administration of N2O, fluroxene, isof... | General anesthetics and regional hypoxic pulmonary vasoconstriction. Administration of N2O, fluroxene and isoflurane to the left lower lobe (LLL) of dogs anesthetized with pentobarbital was previously shown to inhibit LLL hypoxic pulmonary vasoconstriction (HPV). Using the same experimental model, the present study exa... | [
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PMID:13683 | Control of breathing using an extracorporeal membrane lung. | Various amounts of carbon dioxide were removed through an extracorporeal membrane lung in spontaneously breathing lambs. The decrease in alveolar ventilation was proportional to the fraction of total carbon dioxide removed by the membrane lung. When extracorporeal CO2 removal approximated CO2 production (VCO2), alveola... | Control of breathing using an extracorporeal membrane lung. Various amounts of carbon dioxide were removed through an extracorporeal membrane lung in spontaneously breathing lambs. The decrease in alveolar ventilation was proportional to the fraction of total carbon dioxide removed by the membrane lung. When extracorpo... | [
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PMID:13684 | Kinetic analysis of the AH8165-receptor interaction at the mammalian neuromuscular junction. | The effect of a new neuromuscular blocking agent, AH8165, on carbachol-induced end-plate depolarization was measured in isolated guinea pig lumbrical muscles. The results showed that the kinetics were competitive (parallel shift of dose-response curves to the right and a slope of Schild plot of 1.09 +/- 0.07) and the A... | Kinetic analysis of the AH8165-receptor interaction at the mammalian neuromuscular junction. The effect of a new neuromuscular blocking agent, AH8165, on carbachol-induced end-plate depolarization was measured in isolated guinea pig lumbrical muscles. The results showed that the kinetics were competitive (parallel shif... | [
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PMID:13681 | Comparison of THAM and sodium bicarbonate in resuscitation of the heart after ventricular fibrillation in dogs. | Tris (hydroxymethyl) aminomethane (tromethamine or THAM) has been suggested as an effective substitute for sodium bicarbonate (NaHCO3) in the treatment of metabolic acidosis accompanying cardiac arrest. Even though several reports on its appraisal have been published, there is still no clear agreement on its therapeuti... | Comparison of THAM and sodium bicarbonate in resuscitation of the heart after ventricular fibrillation in dogs. Tris (hydroxymethyl) aminomethane (tromethamine or THAM) has been suggested as an effective substitute for sodium bicarbonate (NaHCO3) in the treatment of metabolic acidosis accompanying cardiac arrest. Even ... | [
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PMID:13685 | [Drugs combined with neuroleptics in anesthesia]. | The neuroleptics are characterised by the large number of pharmacological effects they develop. When they are associated with other substances, it is frequent for the latter to have with neuroleptics one or several common sites of action. At this level, they develop phenomena of drug interaction, for example, synergy w... | [Drugs combined with neuroleptics in anesthesia]. The neuroleptics are characterised by the large number of pharmacological effects they develop. When they are associated with other substances, it is frequent for the latter to have with neuroleptics one or several common sites of action. At this level, they develop phe... | [
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PMID:13686 | [The origin and success of neuroleptics]. | The authors retrace the origin and the development of the idea of neurolepsy in anesthesiology, first under the influence of Laborit, and in psychiatry, under the influence of Delay and Deniker, during the early 1950's. In these two fields, neuroleptic drugs were considered contrary to ideas and practice at that time a... | [The origin and success of neuroleptics]. The authors retrace the origin and the development of the idea of neurolepsy in anesthesiology, first under the influence of Laborit, and in psychiatry, under the influence of Delay and Deniker, during the early 1950's. In these two fields, neuroleptic drugs were considered con... | [
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PMID:13688 | [Neuroplegia: results of an interdisciplinary approach to its physiopathology]. | Neuroplegia was born from a physiopathological study of states of shock and research on inhibition of the autonomic reaction to aggression. Over the last 25 years, the experimental facts have become accumulated in favour of the first theory of H. Laborit, i.e. that this so-called defence reaction defended our lives onl... | [Neuroplegia: results of an interdisciplinary approach to its physiopathology]. Neuroplegia was born from a physiopathological study of states of shock and research on inhibition of the autonomic reaction to aggression. Over the last 25 years, the experimental facts have become accumulated in favour of the first theory... | [
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PMID:13690 | [Neurophysiologic justification of the place of neuroleptics in neuroleptanalgesia]. | We studied the action of drugs on the cortical and systemic hemodynamic responses to reticular stimulation and somatic nociceptive stimulation. Central analgesics, even in high dosage, do not suppress the awakening reaction and the attack of hypertension produced by sciatic stimulation in curarised cats. The addition o... | [Neurophysiologic justification of the place of neuroleptics in neuroleptanalgesia]. We studied the action of drugs on the cortical and systemic hemodynamic responses to reticular stimulation and somatic nociceptive stimulation. Central analgesics, even in high dosage, do not suppress the awakening reaction and the att... | [
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PMID:13691 | [Endocrine effects of neuroleptics]. | The neuroleptic drugs used in anesthetics belong to the group of phenothiazines or butyrophenones. The endocrine response to their intravenous administration is still ill-known and usually only concerns the association of anesthetics and neuroleptics. However, as far as the catecholamines are concerned, it is known tha... | [Endocrine effects of neuroleptics]. The neuroleptic drugs used in anesthetics belong to the group of phenothiazines or butyrophenones. The endocrine response to their intravenous administration is still ill-known and usually only concerns the association of anesthetics and neuroleptics. However, as far as the catechol... | [
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PMID:13692 | [Sympathetic-adrenergic and hypophysial response to different anesthesia-analgesia technics]. | The authors used techniques of pure anesthesia analgesia with Fentathienyl-Pavulon, or anesthesia and analgesia potentialised with Fentathienyl-Flunitrazepam, or Pentothal-Fentathienyl-Pavulon on various series of patients. The study was oriented on changes in the sympathetico-adrenalin pituitary response, and the use ... | [Sympathetic-adrenergic and hypophysial response to different anesthesia-analgesia technics]. The authors used techniques of pure anesthesia analgesia with Fentathienyl-Pavulon, or anesthesia and analgesia potentialised with Fentathienyl-Flunitrazepam, or Pentothal-Fentathienyl-Pavulon on various series of patients. Th... | [
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PMID:13693 | [Limits of pure analgesic anesthesia]. | Before dealing with this subject, the author believes that it is useful to give a definition of this technique and justify it. He then recalls the results which he obtained with various analgesic drugs, few products permit this technique, either because of too low analgesic power, or because of the appearance in high d... | [Limits of pure analgesic anesthesia]. Before dealing with this subject, the author believes that it is useful to give a definition of this technique and justify it. He then recalls the results which he obtained with various analgesic drugs, few products permit this technique, either because of too low analgesic power,... | [
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PMID:13695 | [Definition of the antineurotic, antipsychotic, neuroplegic and neuroleptic properties of psychotropic substances used in anesthesia and resuscitation]. | There is a great deal of evidences (pharmacological, experimental and clinical, therapeutic, biological, biochemical, metabolic, toxicological and neurophysiological) which permits one to characterise among the psychotropic substances, the antineurotic or antipsychotic properties of certain psycholeptic drugs. They au... | [Definition of the antineurotic, antipsychotic, neuroplegic and neuroleptic properties of psychotropic substances used in anesthesia and resuscitation]. There is a great deal of evidences (pharmacological, experimental and clinical, therapeutic, biological, biochemical, metabolic, toxicological and neurophysiological) ... | [
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PMID:13696 | Bone marrow transplantation with intensive combination chemotherapy/radiation therapy (SCARI) in acute leukemia. | Fifteen patients with acute leukemia resistant to standard chemotherapy were treated by bone marrow transplantation from HLA-matched siblings after conditioning with a new combination chemotherapy/radiation therapy regimen--SCARI. SCARI consists of 5 days of high-dose cytosine arabinoside and 6-thioguanine followed by ... | Bone marrow transplantation with intensive combination chemotherapy/radiation therapy (SCARI) in acute leukemia. Fifteen patients with acute leukemia resistant to standard chemotherapy were treated by bone marrow transplantation from HLA-matched siblings after conditioning with a new combination chemotherapy/radiation ... | [
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PMID:13697 | Effect of sera from immunologically altered mice on phytohemagglutinin-induced mouse lymphocyte transformation. | The DNA-synthetic response of mouse spleen cells to phytohemagglutinin in vitro is depressed by the addition of normal mouse serum. The effects of sera from mice that had been modified immunologically were examined. Increased depressive activity was found in sera from nude mice and from mice recently treated with anti-... | Effect of sera from immunologically altered mice on phytohemagglutinin-induced mouse lymphocyte transformation. The DNA-synthetic response of mouse spleen cells to phytohemagglutinin in vitro is depressed by the addition of normal mouse serum. The effects of sera from mice that had been modified immunologically were ex... | [
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PMID:13699 | [Feeding and growth of elvers of anguilla Anguilla L. (eel-like teleosten fish) experimentally reared at various temperatures in the laboratory]. | In France, there are few researches carried out on the eel's elvers rearing. So, we have undertaken to do, in a first time, a study of their alimentation and growth, in relation to the temperature, at laboratory. The structure of european eels' elvers population, drawn in its natural environment, shows a polymodal freq... | [Feeding and growth of elvers of anguilla Anguilla L. (eel-like teleosten fish) experimentally reared at various temperatures in the laboratory]. In France, there are few researches carried out on the eel's elvers rearing. So, we have undertaken to do, in a first time, a study of their alimentation and growth, in relat... | [
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PMID:13702 | Measurement of ionised calcium in body fluids-a review. | This paper reviews the techniques available to the clinical biochemist for measuring ionised calcium concentrations in biological fluids with particular reference to serum. At present ionised calcium may be measured colorimetrically, using tetramethyl murexide, or potentiometrically, using a calcium ion-selective elect... | Measurement of ionised calcium in body fluids-a review. This paper reviews the techniques available to the clinical biochemist for measuring ionised calcium concentrations in biological fluids with particular reference to serum. At present ionised calcium may be measured colorimetrically, using tetramethyl murexide, or... | [
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PMID:13704 | Comparative in vitro activity of piribenicillin, ticarcillin, and carbenicillin against Pseudomonas aeruginosa. | Pirbenicillin, a semisynthetic penicillin, showed greater in vitro activity against 68 recent isolates of Pseudomonas aeruginosa than did ticarcillin or carbenicillin. The median minimum inhibitory concentration of each of these three compounds, respectively, was 3.1, 12.5, and 25 mug/ml when a 10(-4) dilution of an ov... | Comparative in vitro activity of piribenicillin, ticarcillin, and carbenicillin against Pseudomonas aeruginosa. Pirbenicillin, a semisynthetic penicillin, showed greater in vitro activity against 68 recent isolates of Pseudomonas aeruginosa than did ticarcillin or carbenicillin. The median minimum inhibitory concentrat... | [
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PMID:13705 | Beta-Lactamase activity in strains of Bacteroides melaninogenicus and Bacteroides oralis. | beta-Lactamase from strains of Bacteroides melaninogenicus and Bacteroides oralis hydrolyzed penicillin more rapidly than ampicillin or carbenicillin. Cephalothin and a chromogenic cephalosporin (87/312) were also hydrolyzed by the enzyme. Activity was found only in beta-lactam-resistant strains, but there was consider... | Beta-Lactamase activity in strains of Bacteroides melaninogenicus and Bacteroides oralis. beta-Lactamase from strains of Bacteroides melaninogenicus and Bacteroides oralis hydrolyzed penicillin more rapidly than ampicillin or carbenicillin. Cephalothin and a chromogenic cephalosporin (87/312) were also hydrolyzed by th... | [
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PMID:13706 | Purification and properties of an NADP+-specific isocitrate dehydrogenase from Rhizobium meliloti. | An NADP+-specific isocitrate dehydrogenase has been purified and characterized from Rhizobium meliloti. The enzyme showed Mn++ or Mg++ requirement. The apparent Km values were 2.00 x 10(-5) M and 1.51 x 10(-5) M for DL-isocitrate and NADP+, respectively. The enzyme was inhibited by ATP, to a lesser extent by ADP and AM... | Purification and properties of an NADP+-specific isocitrate dehydrogenase from Rhizobium meliloti. An NADP+-specific isocitrate dehydrogenase has been purified and characterized from Rhizobium meliloti. The enzyme showed Mn++ or Mg++ requirement. The apparent Km values were 2.00 x 10(-5) M and 1.51 x 10(-5) M for DL-is... | [
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PMID:13703 | Significance of gamma-glutamyl transferase (GGT) activity measurements in alcohol-induced hepatic injury. | Experimental evidence is presented that the determination of gamma-glutamyl transferase (GGT) activity in serum is useful in the assessment of alcohol-induced liver disease and for demonstrating to patients the toxic effects of their drinking habits on the liver. Serial measurements of GGT activity in serum have also p... | Significance of gamma-glutamyl transferase (GGT) activity measurements in alcohol-induced hepatic injury. Experimental evidence is presented that the determination of gamma-glutamyl transferase (GGT) activity in serum is useful in the assessment of alcohol-induced liver disease and for demonstrating to patients the tox... | [
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PMID:13707 | Mating reaction in Saccharomyces cerevisiae. X. Agglutinability-inactivating factor: a factor which destroys sexual agglutinability of a mating-type cells. | From cells of Saccharomyces cerevisiae a factor has been extracted that destroys the agglutinability of a mating-type cells specifically. It was found in the cell extracts of diploid and tetraploid strains as well as haploid strains of a and alpha mating types. It is heat-labile and the molecular weight is about 50,000... | Mating reaction in Saccharomyces cerevisiae. X. Agglutinability-inactivating factor: a factor which destroys sexual agglutinability of a mating-type cells. From cells of Saccharomyces cerevisiae a factor has been extracted that destroys the agglutinability of a mating-type cells specifically. It was found in the cell e... | [
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PMID:13709 | Hydrolysis of lactose by immobilized microorganisms. | Cells of Lactobacillus bulgaricus, Escherichia coli, and Kluyveromyces (Saccharomyces) lactis immobilized in polyacrylamide gel beads retained 27 to 61% of the beta-galactosidase activity of intact cells. Optimum temperature and pH and thermostability of these microbial beta-galactosidases were negligibly affected by t... | Hydrolysis of lactose by immobilized microorganisms. Cells of Lactobacillus bulgaricus, Escherichia coli, and Kluyveromyces (Saccharomyces) lactis immobilized in polyacrylamide gel beads retained 27 to 61% of the beta-galactosidase activity of intact cells. Optimum temperature and pH and thermostability of these microb... | [
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PMID:13710 | Deconjugation of bile acids by intestinal lactobacilli. | Lactobacillus species normally found in the intestinal tract of humans varied in the ability to deconjugate bile acids, whereas laboratory strains of Lactobacillus acidophilus deconjugated both glycocholate and taurocholate. All isolates of L. acidophilus from human feces deconjugated taurocholate, whereas only one of ... | Deconjugation of bile acids by intestinal lactobacilli. Lactobacillus species normally found in the intestinal tract of humans varied in the ability to deconjugate bile acids, whereas laboratory strains of Lactobacillus acidophilus deconjugated both glycocholate and taurocholate. All isolates of L. acidophilus from hum... | [
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PMID:13711 | Aggregation of poliovirus and reovirus by dilution in water. | Poliovirus and reovirus were found to aggregate into clumps of up to several hundred particles when diluted 10-fold into distilled water from a stock preparation of minimal aggregation in 0.05 M phosphate buffer, pH 7.2, plus 22 to 30% sucrose. Reovirus was also found to aggregate when diluted into phosphate-buffered s... | Aggregation of poliovirus and reovirus by dilution in water. Poliovirus and reovirus were found to aggregate into clumps of up to several hundred particles when diluted 10-fold into distilled water from a stock preparation of minimal aggregation in 0.05 M phosphate buffer, pH 7.2, plus 22 to 30% sucrose. Reovirus was a... | [
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PMID:13712 | Ionic bonding, the mechanism of viral uptake by shellfish mucus. | An investigation was conducted to determine the processes involved in the contamination of shellfish by viruses. Results of binding-release studies show that the process involves the attachment of viruses to mucus secreted, and then ingested, by shellfish during feeding. Analysis of the mucus-virus bond involved select... | Ionic bonding, the mechanism of viral uptake by shellfish mucus. An investigation was conducted to determine the processes involved in the contamination of shellfish by viruses. Results of binding-release studies show that the process involves the attachment of viruses to mucus secreted, and then ingested, by shellfish... | [
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PMID:13713 | Fermentation of L-aspartate by a saccharolytic strain of Bacteroides melaninogenicus. | Resting cells of Bacteroides melaninogenicus fermented L-[14C]aspartate as a single substrate. The 14C-labeled products included succinate, acetate, CO2, oxaloacetate, formate, malate, glycine, alanine, and fumarate in the relative percentages 68, 15, 9.9, 2.7, 1.8, 1.0, 0.7, 0.5, and 0.06, respectively, based on the t... | Fermentation of L-aspartate by a saccharolytic strain of Bacteroides melaninogenicus. Resting cells of Bacteroides melaninogenicus fermented L-[14C]aspartate as a single substrate. The 14C-labeled products included succinate, acetate, CO2, oxaloacetate, formate, malate, glycine, alanine, and fumarate in the relative pe... | [
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PMID:13714 | Sanitation in self-service automatic washers. | The potential for microbial transfer in self-service laundry washing machines was investigated by obtaining swab samples from the interior surfaces of commercial machines and wash water samples before and after disinfectant treatment. Three disinfectants (chlorine, a quaternary ammonium product, and a phenolic disinfec... | Sanitation in self-service automatic washers. The potential for microbial transfer in self-service laundry washing machines was investigated by obtaining swab samples from the interior surfaces of commercial machines and wash water samples before and after disinfectant treatment. Three disinfectants (chlorine, a quater... | [
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PMID:13739 | Solar uticaria. Photoallergen in a patient's serum. | A 45-year-old man had solar urticaria that was activated by visible light. Passive transfer of the reactivity with the patient's serum to the skin of normal recipients was accomplished. Results of reverse passive transfer studies were negative. The patient developed an urticarial wheal at the site of injection of his o... | Solar uticaria. Photoallergen in a patient's serum. A 45-year-old man had solar urticaria that was activated by visible light. Passive transfer of the reactivity with the patient's serum to the skin of normal recipients was accomplished. Results of reverse passive transfer studies were negative. The patient developed a... | [
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PMID:13740 | Some aspects of the persistence and fate of acrolein herbicide in water. | Experimental data for the decay of acrolein approximated first order kinetics. The reaction continued to completion in local waters but in buffered solution (pH 5.1-8.6) an equilibrium was reached after reaction of about 92% of the acrolein. It is proposed that data presented on the effects of pH on decay of acrolein m... | Some aspects of the persistence and fate of acrolein herbicide in water. Experimental data for the decay of acrolein approximated first order kinetics. The reaction continued to completion in local waters but in buffered solution (pH 5.1-8.6) an equilibrium was reached after reaction of about 92% of the acrolein. It is... | [
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PMID:13741 | [Bacteriological examination of sputum (author's transl)]. | The AA., emphasizing the importance of ascertain the bronchial source of microorganisms recoverable from sputum, recommend for this purpose the use of properly collected sputum specimens and the application of washing treatment for mucopurulent materials. The aim of the present study has been to verify the effectivenes... | [Bacteriological examination of sputum (author's transl)]. The AA., emphasizing the importance of ascertain the bronchial source of microorganisms recoverable from sputum, recommend for this purpose the use of properly collected sputum specimens and the application of washing treatment for mucopurulent materials. The a... | [
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PMID:13742 | [Study on the viscolytic activity of the sputum (author's transl)]. | Several mucolytic agents were evaluated on sputum for testing their viscolytic activity and the bacterial tollerance to each of them. Proteolytic enzymes (trypsin, pepsin, papain, pancreatin), KJ, and dithiothreitol (or its derivatives) were better tollerated by common respiratory pathogens (H. influenzae, D. pneumonia... | [Study on the viscolytic activity of the sputum (author's transl)]. Several mucolytic agents were evaluated on sputum for testing their viscolytic activity and the bacterial tollerance to each of them. Proteolytic enzymes (trypsin, pepsin, papain, pancreatin), KJ, and dithiothreitol (or its derivatives) were better tol... | [
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PMID:13743 | [Aerobic flora examination of sputum (author's transl)]. | The routine bacteriological test of expectorate, except for mycobacteria, is usually unsatisfactory. There is a need of standardization which results in the present paper from a comparison between the data obtained by two different laboratories on the same samples. It is possible to achieve reasonable and uniform resul... | [Aerobic flora examination of sputum (author's transl)]. The routine bacteriological test of expectorate, except for mycobacteria, is usually unsatisfactory. There is a need of standardization which results in the present paper from a comparison between the data obtained by two different laboratories on the same sample... | [
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PMID:13744 | [Resistance to antibiotics of bacteria involved in respiratory infections (author's transl)]. | The present status of resistance to antibiotics of bacteria involved in respiratory infections is reviewed. Schematically it can outlined as follows. Streptococcus B-haemolyticus as well as Pneumococcus did not change their sensitivity to penicillin, but some strains are now resistant to tetracycline. Streptococcus vir... | [Resistance to antibiotics of bacteria involved in respiratory infections (author's transl)]. The present status of resistance to antibiotics of bacteria involved in respiratory infections is reviewed. Schematically it can outlined as follows. Streptococcus B-haemolyticus as well as Pneumococcus did not change their se... | [
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PMID:13746 | Treatment of hemorrhagic gastritis by antacid. | A simple and safe method of nonsurgical treatment for the control of massive acute gastric mucosal hemorrhage is described. The procedure was developed from experimental and clinical observations that the presence of gastric hydrocloric acid played an important part in the development and perpetuation of the entity. Th... | Treatment of hemorrhagic gastritis by antacid. A simple and safe method of nonsurgical treatment for the control of massive acute gastric mucosal hemorrhage is described. The procedure was developed from experimental and clinical observations that the presence of gastric hydrocloric acid played an important part in the... | [
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PMID:13747 | Patterns of gastroesophageal reflux in health and disease. | Twenty-four pH monitoring the distal esophagus quantitates gastroesophageal reflux in a near physiologic setting by measuring the frequency and duration of acid exposure to the esophageal mucosa. Fifteen asymptomatic volunteers were studies with 24-hour pH and esophageal manometry. The normal cardia was more competent ... | Patterns of gastroesophageal reflux in health and disease. Twenty-four pH monitoring the distal esophagus quantitates gastroesophageal reflux in a near physiologic setting by measuring the frequency and duration of acid exposure to the esophageal mucosa. Fifteen asymptomatic volunteers were studies with 24-hour pH and ... | [
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PMID:13748 | Long-term follow-up of internal mammary artery myocardial implantation. | A study was made of 100 patients who had undergone internal mammary artery myocardial implantation 7 to 10 years previously. Forty-two patients had single implantation with or without a free omental graft, and 54 received double implantations. Four patients had a single internal mammary artery implant plus a single aor... | Long-term follow-up of internal mammary artery myocardial implantation. A study was made of 100 patients who had undergone internal mammary artery myocardial implantation 7 to 10 years previously. Forty-two patients had single implantation with or without a free omental graft, and 54 received double implantations. Four... | [
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PMID:13749 | Inhibition of prostaglandin biosynthesis by non-narcotic analgesic drugs. | The existence of a relationship between inhibition of prostaglandin biosynthesis and analgesic or anti-inflammatory activity was investigated in the case of the non-narcotic analgesics glafenine, floctafenine and clometacine, in comparison to indomethacin and acetylsalicylic acid. These compounds inhibit prostaglandin ... | Inhibition of prostaglandin biosynthesis by non-narcotic analgesic drugs. The existence of a relationship between inhibition of prostaglandin biosynthesis and analgesic or anti-inflammatory activity was investigated in the case of the non-narcotic analgesics glafenine, floctafenine and clometacine, in comparison to ind... | [
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PMID:13750 | Selectivity of clenbuterol (NAB 365) in guinea-pig isolated tissues containing beta-adrenoceptors. | The effects of clenbuterol (ANB 365), an aminohalogen substituted phenylethanolamine, have been examined on isolated tissue preparations from guinea-pigs. Clenbuterol produced concentration (or dose)-dependent relaxations of tracheal chains, decreases in perfusion pressure of hind limb blood vessels, inhibitions of ace... | Selectivity of clenbuterol (NAB 365) in guinea-pig isolated tissues containing beta-adrenoceptors. The effects of clenbuterol (ANB 365), an aminohalogen substituted phenylethanolamine, have been examined on isolated tissue preparations from guinea-pigs. Clenbuterol produced concentration (or dose)-dependent relaxations... | [
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PMID:13751 | Serum corticosterone as a quantitative test of the phlogistic potency of various agents topically applied in the rat. | The application into the rat conjunctiva of various phlogistic agents, such as croton oil, mustard oil and formaldehyde, elicits an increase of serum corticosterone linearly related to the log of the applied concentrations, so that from their parallelized regression lines it is possible to calculate the phlogistic pote... | Serum corticosterone as a quantitative test of the phlogistic potency of various agents topically applied in the rat. The application into the rat conjunctiva of various phlogistic agents, such as croton oil, mustard oil and formaldehyde, elicits an increase of serum corticosterone linearly related to the log of the ap... | [
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PMID:13753 | Photoproduction of ammonium ion from N2 in Rhodospirillum rubrum. | NH+4 excretion was undetectable in N2-fixing cultures of Rhodospirillum rubrum (S-1) and nitrogenase activity in these cultures was repressed by the addition of 10 mM NH+4 to the medium. The glutamate analog, L-methionine-DL-sulfoximine (MSX), derepressed N2 fixation even in the presence of 10 mM extracellular NH+4. Wh... | Photoproduction of ammonium ion from N2 in Rhodospirillum rubrum. NH+4 excretion was undetectable in N2-fixing cultures of Rhodospirillum rubrum (S-1) and nitrogenase activity in these cultures was repressed by the addition of 10 mM NH+4 to the medium. The glutamate analog, L-methionine-DL-sulfoximine (MSX), derepresse... | [
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PMID:13754 | Energy coupling and respiration in Nitrosomonas europaea. | Intact cells of Nitrosomonas europaea grown in an ammonium salts medium will oxidise ammonium ions, hydroxylamine and ascorbate-TMPD; there is no oxidation of carbon monoxide, methane or methanol. The Km value for ammonia oxidation is highly pH dependent with a minimum value of 0.5 mM above pH 8.0. This suggests that f... | Energy coupling and respiration in Nitrosomonas europaea. Intact cells of Nitrosomonas europaea grown in an ammonium salts medium will oxidise ammonium ions, hydroxylamine and ascorbate-TMPD; there is no oxidation of carbon monoxide, methane or methanol. The Km value for ammonia oxidation is highly pH dependent with a ... | [
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PMID:13755 | D-Alanine dehydrogenase. Its role in the utilisation of alanine isomers as growth substrates by Pseudomonas aeruginosa PA01. | Pseudomonas aeruginosa PA01 was found to utilise both the D- and L-isomers of alpha-alanine and also beta-alanine as sole sources of carbon and energy for growth. Enzymological studies of wild-type cultures and comparison with mutants deficient in growth upon one or more isomers of alanine led to the following conclusi... | D-Alanine dehydrogenase. Its role in the utilisation of alanine isomers as growth substrates by Pseudomonas aeruginosa PA01. Pseudomonas aeruginosa PA01 was found to utilise both the D- and L-isomers of alpha-alanine and also beta-alanine as sole sources of carbon and energy for growth. Enzymological studies of wild-ty... | [
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PMID:13756 | Monosaccharide transport systems in the yeast Rhodotorula glutinis. | By using D-glucose, D-xylose, D-galactose and D-fructose in the strictly aerobic yeast Rhodotorula glutinis and by comparing the half-saturation constants with inhibition constants the yeast was shown to possess a single common system for D-xylose and D-galactose (Km's and Ki's all between 0.5 and 1.1 mM) but another d... | Monosaccharide transport systems in the yeast Rhodotorula glutinis. By using D-glucose, D-xylose, D-galactose and D-fructose in the strictly aerobic yeast Rhodotorula glutinis and by comparing the half-saturation constants with inhibition constants the yeast was shown to possess a single common system for D-xylose and ... | [
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PMID:13757 | Energetic aspects of anaerobic growth of Aerobacter aerogenes in complex medium. | Molar growth yields for anaerobic growth of Aerobacter aerogenes in complex medium were much higher than for growth in minimal medium. In batch cultures the molar growth yield for glucose varied from 44 to 50 and YATP from 17.1 to 18.8. For glucose-limited chemostat cultures a value of 17.5 g/mole was found for Y max A... | Energetic aspects of anaerobic growth of Aerobacter aerogenes in complex medium. Molar growth yields for anaerobic growth of Aerobacter aerogenes in complex medium were much higher than for growth in minimal medium. In batch cultures the molar growth yield for glucose varied from 44 to 50 and YATP from 17.1 to 18.8. Fo... | [
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PMID:13758 | Proton-motive force and the motile behavior of Bacillus subtilis. | Changes in the proton-motive force cause a transient change in the motile behavior of Bacillus subtilis cells. Both an increase and a decrease in the proton-motive force caused transient tumbling. Simultaneous decrease of proton-motive force and increase of attractant concentration lessens the response toward the attra... | Proton-motive force and the motile behavior of Bacillus subtilis. Changes in the proton-motive force cause a transient change in the motile behavior of Bacillus subtilis cells. Both an increase and a decrease in the proton-motive force caused transient tumbling. Simultaneous decrease of proton-motive force and increase... | [
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PMID:13759 | Ammonium uptake and metabolism by mitrogen fixing bacteria. II. Klebsiella pneumoniae. | The primary steps of N2, ammonia and nitrate metabolism in Klebsiella pneumoniae grown in a continuous culture are regulated by the kind and supply of the nitrogenous compound. Cultures growing on N2 as the only nitrogen source have high activities of nitrogenase, unadenylated glutamine synthetase and glutamate synthas... | Ammonium uptake and metabolism by mitrogen fixing bacteria. II. Klebsiella pneumoniae. The primary steps of N2, ammonia and nitrate metabolism in Klebsiella pneumoniae grown in a continuous culture are regulated by the kind and supply of the nitrogenous compound. Cultures growing on N2 as the only nitrogen source have ... | [
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PMID:13760 | Ammonia assimilation in the fission yeast Schizosaccharomyces pombe 972. | Glutamine synthetase (GS) activity of Schizosaccharomyces pombe 972 was high in ammonia-limited cultures, low in phosphate- and sulphate-limited cultures and not detected in glucose-limited cultures. When ammonia was 'pulsed' into an ammonia-limited culture then GS activity decreased at a rate faster than that calculat... | Ammonia assimilation in the fission yeast Schizosaccharomyces pombe 972. Glutamine synthetase (GS) activity of Schizosaccharomyces pombe 972 was high in ammonia-limited cultures, low in phosphate- and sulphate-limited cultures and not detected in glucose-limited cultures. When ammonia was 'pulsed' into an ammonia-limit... | [
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PMID:13761 | Monoamine metabolism in human brain. | Norepinephrine (NE), dopamine (DA), tyrosine hydroxylase (TH), catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO) levels were measured in human brain tissue obtained at autopsy from a series of 39 patients dying of various medical and accidental causes. The nine following brain areas were studied: globus p... | Monoamine metabolism in human brain. Norepinephrine (NE), dopamine (DA), tyrosine hydroxylase (TH), catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO) levels were measured in human brain tissue obtained at autopsy from a series of 39 patients dying of various medical and accidental causes. The nine followi... | [
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PMID:13762 | [Management of second stage of labour: observations, reflections, advices (author's transl)]. | All vaginal deliveries of the Department of Obstetrics and Gynecology of the University Basel (N = 4081) during the year 74/73 and of the University Tübingen (N = 3249) 75/74 were analysed using an IBM-system 370/135 Only alive singletons beyond the 28th week of gestation were analysed. Clinical management was quite di... | [Management of second stage of labour: observations, reflections, advices (author's transl)]. All vaginal deliveries of the Department of Obstetrics and Gynecology of the University Basel (N = 4081) during the year 74/73 and of the University Tübingen (N = 3249) 75/74 were analysed using an IBM-system 370/135 Only aliv... | [
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PMID:13763 | Antibiotics produced by Streptomyces olivaceus 142. I. Characterization of the FPG mutant and conditions of production of antibiotic WR 142-FPG. | By treating the Streptomyces olivaceus 142 strain simultaneously with ethyleneimine and UV radiation, the FPG mutant was isolated, which was characterized by the fact that in submerged cultures it produces a cytotoxic substance for fibroblasts and tumor cells and inhibits growth of pathogenic fungi. The mutant differs ... | Antibiotics produced by Streptomyces olivaceus 142. I. Characterization of the FPG mutant and conditions of production of antibiotic WR 142-FPG. By treating the Streptomyces olivaceus 142 strain simultaneously with ethyleneimine and UV radiation, the FPG mutant was isolated, which was characterized by the fact that in ... | [
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PMID:13764 | Search for new aminoguanidine derivatives with immunosuppressive and cytostatic properties. I. Reactions of amino-, nitroamino- and diaminoguanidine with acetylpyruvic acid ethyl ester. | Reactions of amino-, nitroamino- and diaminoguanidine (I, II, III) with acetylpyruvic acid ethyl ester (IV) at varying pH of the medium were studied. It was found that the nucleophilic hydrazine NH2 group of compounds I, II, and III) attacks the keto group of ester IV in position gamma or alpha. The newly synthesized c... | Search for new aminoguanidine derivatives with immunosuppressive and cytostatic properties. I. Reactions of amino-, nitroamino- and diaminoguanidine with acetylpyruvic acid ethyl ester. Reactions of amino-, nitroamino- and diaminoguanidine (I, II, III) with acetylpyruvic acid ethyl ester (IV) at varying pH of the mediu... | [
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PMID:13765 | Sustrate-specificity of glucomylase (E.C. 3.2.1.3) exemplified by p-nitroaniline n-glucosides. | The present paper supplements the previous investigations on the mechanism of reactions catalyzed by amylolytic enzymes. The performed experiments corroborated the data on transglucosylative properties of animal glucoamylases which were found to depend on the structure and concentration of substrate. The p-nitroaniline... | Sustrate-specificity of glucomylase (E.C. 3.2.1.3) exemplified by p-nitroaniline n-glucosides. The present paper supplements the previous investigations on the mechanism of reactions catalyzed by amylolytic enzymes. The performed experiments corroborated the data on transglucosylative properties of animal glucoamylases... | [
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PMID:13766 | Effect of acid pH, salts, and temperature on the infectivity and physical integrity of enteroviruses. | At 2 degrees and 30 degrees C, enteroviruses are more stable on the acid than on the alkaline side of neutrality. In the range from pH 3 to 9, temperature is so influential that the fastest inactivation rate at 2 degrees C is slower than the slowest inactivation rate at 30 degrees C. Specific ions or salts also affect ... | Effect of acid pH, salts, and temperature on the infectivity and physical integrity of enteroviruses. At 2 degrees and 30 degrees C, enteroviruses are more stable on the acid than on the alkaline side of neutrality. In the range from pH 3 to 9, temperature is so influential that the fastest inactivation rate at 2 degre... | [
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PMID:13767 | Investigation on the infection of cucumber mesophyll protoplasts with cucumber mosaic virus. | Isolated protoplasts from the first leaf mesophyll of cucumber plants have been successfully infected in vitro with cucumber mosaic virus (CMV). Virus instability before, during and after inoculation of the protoplasts resulted in low infectivities when extracts were assayed on cowpea; however, viral RNA extraction imp... | Investigation on the infection of cucumber mesophyll protoplasts with cucumber mosaic virus. Isolated protoplasts from the first leaf mesophyll of cucumber plants have been successfully infected in vitro with cucumber mosaic virus (CMV). Virus instability before, during and after inoculation of the protoplasts resulted... | [
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PMID:13768 | Thymidine-kinase in cytomegalovirus infected cells. | In human diploid fibroblast LEP cells infected with AD169 strain of human cytomegalovirus (CMV) a sharp increase of cytosol thymidine kinase activity was observed. The properties of the cytosol enzymes from infected and non-infected cells were compared. No significant differences between the enzymes from infected and c... | Thymidine-kinase in cytomegalovirus infected cells. In human diploid fibroblast LEP cells infected with AD169 strain of human cytomegalovirus (CMV) a sharp increase of cytosol thymidine kinase activity was observed. The properties of the cytosol enzymes from infected and non-infected cells were compared. No significant... | [
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PMID:13769 | [Role of viral-bacterial associations in meningitis in children]. | A total of 50 section cases of meningitis in children were investigated. All patients revealed acute viral respiratory infections with generalization, including lesions of the central nervous system (CNS). In 14 children moreover meningococcal infection was diagnosed. In 30 children lesions of the CNS were due to mixed... | [Role of viral-bacterial associations in meningitis in children]. A total of 50 section cases of meningitis in children were investigated. All patients revealed acute viral respiratory infections with generalization, including lesions of the central nervous system (CNS). In 14 children moreover meningococcal infection ... | [
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PMID:13770 | [Structural and functional characteristics of the spleen in systemic and local allogenic graft versus host reaction]. | Morphological and histochemical characteristics of the spleen in the systemic and locally induced in the spleen transplant host reaction were compared. In both forms there were observed infiltration of the organ with macrophages and pyroninophilial blasts characterized by a high level of the activity of enzymes of lyso... | [Structural and functional characteristics of the spleen in systemic and local allogenic graft versus host reaction]. Morphological and histochemical characteristics of the spleen in the systemic and locally induced in the spleen transplant host reaction were compared. In both forms there were observed infiltration of ... | [
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PMID:13773 | Murray Valley encephalitis virus infection in mosquitoes and domestic fowls in Queensland, 1974. | Field studies during an epidemic of Murray Valley encephalitis (MVE) led to the isolation of MVE virus from a pool of mosquitoes (Culex annulirostris) and a sentinel chicken from Charleville, south-west Queensland. A high proportion of domestic fowls at Charleville had antibody to MVE virus at the beginning of February... | Murray Valley encephalitis virus infection in mosquitoes and domestic fowls in Queensland, 1974. Field studies during an epidemic of Murray Valley encephalitis (MVE) led to the isolation of MVE virus from a pool of mosquitoes (Culex annulirostris) and a sentinel chicken from Charleville, south-west Queensland. A high p... | [
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PMID:13774 | Clinical evaluation of a dialysate regeneration system for maintenance haemodialysis. | A commercially available sorbent-based dialysate regeneration system has been compared to conventional single-pass dialysate delivery systems for treatment periods of six weeks in 13 patients on maintenance dialysis. The results of treatment were virtually identical in comparing sorbent and conventional systems except ... | Clinical evaluation of a dialysate regeneration system for maintenance haemodialysis. A commercially available sorbent-based dialysate regeneration system has been compared to conventional single-pass dialysate delivery systems for treatment periods of six weeks in 13 patients on maintenance dialysis. The results of tr... | [
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PMID:13775 | Effects of induced cryptorchidism in bulls. | Ninety bull calves were made cryptorchid by forcing the testes into the abdominal cavity and ablating the scrotum with elastrator rings. Normal spermatogenesis was seen following histological examination of some of the testes approximately 17 months after the operation. No effect on bull behaviour was noted in the cryp... | Effects of induced cryptorchidism in bulls. Ninety bull calves were made cryptorchid by forcing the testes into the abdominal cavity and ablating the scrotum with elastrator rings. Normal spermatogenesis was seen following histological examination of some of the testes approximately 17 months after the operation. No ef... | [
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PMID:13781 | [Tubular structure and germ cell distribution of cryptorchid or normal testes in early childhood (author's transl)]. | Many recent publications have demonstrated that the cryptorchid testicle (and, to a lesser extent, the descended partner) are progressively injured from the second year of life onwards. Do these injuries occur in an organ which has been healthy up to this time or are they superimposed on a structurally abnormal testicl... | [Tubular structure and germ cell distribution of cryptorchid or normal testes in early childhood (author's transl)]. Many recent publications have demonstrated that the cryptorchid testicle (and, to a lesser extent, the descended partner) are progressively injured from the second year of life onwards. Do these injuries... | [
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PMID:13782 | Genetics of peroxisomal enzymes in the mouse: nonlinkage of D-amino acid oxidase locus (Dao) to catalase (Cs) and L-alpha-hydroxyacid oxidase (Hao-1) loci on chromosome 2. | An electrophoretic polymorphism of the peroxisomal enzyme D-amino acid oxidase was observed in NZC strain Mus musculus. F1 (NZC X BALB/c) mice showed a codominant allcle two-banded phenotype which is inconsistent with the dimeric subunit structure reported for this enzyme in other species. The enzyme locus (Dao) was sh... | Genetics of peroxisomal enzymes in the mouse: nonlinkage of D-amino acid oxidase locus (Dao) to catalase (Cs) and L-alpha-hydroxyacid oxidase (Hao-1) loci on chromosome 2. An electrophoretic polymorphism of the peroxisomal enzyme D-amino acid oxidase was observed in NZC strain Mus musculus. F1 (NZC X BALB/c) mice showe... | [
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PMID:13780 | Myocardial function during acute hypoxia in the calf. | Hemodynamics and myocardial contractility were evaluated in five unanesthetized calves during acute hypocapnic and isocapnic hypoxia and during acute hypocapnic hypoxia with beta-adrenergic blockade. Both hypocapnic and isocapnic hypoxia, with mean PaO2 levels of 33.1 and 39.1 mm Hg respectively, produced a decline in ... | Myocardial function during acute hypoxia in the calf. Hemodynamics and myocardial contractility were evaluated in five unanesthetized calves during acute hypocapnic and isocapnic hypoxia and during acute hypocapnic hypoxia with beta-adrenergic blockade. Both hypocapnic and isocapnic hypoxia, with mean PaO2 levels of 33... | [
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PMID:13783 | The maximum activities of hexokinase, phosphorylase, phosphofructokinase, glycerol phosphate dehydrogenases, lactate dehydrogenase, octopine dehydrogenase, phosphoenolpyruvate carboxykinase, nucleoside diphosphatekinase, glutamate-oxaloacetate transaminase and arginine kinase in relation to carbohydrate utilization in ... | Comparison of the activities of hexokinase, phosphorylase and phosphofructokinase in muscles from marine invertebrates indicates that they can be divided into three groups. First, the activities of the three enzymes are low in coelenterate muscles, catch muscles of molluscs and muscles of echinoderms; this indicates a ... | The maximum activities of hexokinase, phosphorylase, phosphofructokinase, glycerol phosphate dehydrogenases, lactate dehydrogenase, octopine dehydrogenase, phosphoenolpyruvate carboxykinase, nucleoside diphosphatekinase, glutamate-oxaloacetate transaminase and arginine kinase in relation to carbohydrate utilization in ... | [
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PMID:13784 | Phosphate transport into brush-border membrane vesicles isolated from rat small intestine. | Uptake of Pi into brush-border membrane vesicles isolated from rat small intestine was investigated by a rapid filtration technique. The following results were obtained. 1. At pH 7.4 in the presence of a NaCl gradient across the membrane (sodium concentration in the medium higher than sodium concentration in the vesicl... | Phosphate transport into brush-border membrane vesicles isolated from rat small intestine. Uptake of Pi into brush-border membrane vesicles isolated from rat small intestine was investigated by a rapid filtration technique. The following results were obtained. 1. At pH 7.4 in the presence of a NaCl gradient across the ... | [
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PMID:13785 | Validation of a simple radiochemical assay measuring hydrolysis of choline-labelled microsomal phosphatidylcholine by phospholipase C. pH-dependence. | Selective hydrolysis of phosphatidylcholine species, which are selectively radioactively labelled in vivo, does not appear to interfere with a radiochemical assay for hydrolysis of microsomal phosphatidylcholine by C-type phospholipases from Bacillus cereus or Clostridium perfringens. Both phospholipases substantially ... | Validation of a simple radiochemical assay measuring hydrolysis of choline-labelled microsomal phosphatidylcholine by phospholipase C. pH-dependence. Selective hydrolysis of phosphatidylcholine species, which are selectively radioactively labelled in vivo, does not appear to interfere with a radiochemical assay for hyd... | [
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PMID:13786 | Transannular dioxygenation of 9,10-dimethyl-1,2-benzanthracene by cytochrome P-450 oxygenase of rat liver. | 9,10-Dimethyl-1,2-benzanthracene is oxygenated by rat liver microsomal cytochrome P-450 oxygenase to its 9,10-epidioxide. This transannular 1,4-peroxide is converted further into the diol by the microsomal preparation and NADPH. These two products constitute the majority of the metabolites found under the conditions de... | Transannular dioxygenation of 9,10-dimethyl-1,2-benzanthracene by cytochrome P-450 oxygenase of rat liver. 9,10-Dimethyl-1,2-benzanthracene is oxygenated by rat liver microsomal cytochrome P-450 oxygenase to its 9,10-epidioxide. This transannular 1,4-peroxide is converted further into the diol by the microsomal prepara... | [
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PMID:13803 | Fatty acid synthesis in aorta. Isolation of fatty acid synthetase from chicken aorta. | Fatty acid synthesis by subcellular fractions of human aorta was studied by measuring the incorporation of either radioactive acetyl-CoA or malonyl-CoA into long chain fatty acids. The high speed supernatant fraction contained fatty acid synthetase and was capable of de novo fatty acid synthesis. The fatty acid synthet... | Fatty acid synthesis in aorta. Isolation of fatty acid synthetase from chicken aorta. Fatty acid synthesis by subcellular fractions of human aorta was studied by measuring the incorporation of either radioactive acetyl-CoA or malonyl-CoA into long chain fatty acids. The high speed supernatant fraction contained fatty a... | [
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PMID:13801 | Effect of altered lymphocyte function on immunologic disorders in NZB/NZW mice. | NZB/NZW F1 female mice were treated with the immunosuppresive enzyme L-asparaginar antibodies, diminished deposition of gamma-globulins in kidneys, significantly delayed the onset of proteinuria, and reduced deaths from nephritis. These effects were associated with reduction of cellular IgM antibody synthesis to both T... | Effect of altered lymphocyte function on immunologic disorders in NZB/NZW mice. NZB/NZW F1 female mice were treated with the immunosuppresive enzyme L-asparaginar antibodies, diminished deposition of gamma-globulins in kidneys, significantly delayed the onset of proteinuria, and reduced deaths from nephritis. These eff... | [
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PMID:13805 | Acute-phase reactant protein profiles: an aid to monitoring large bowel cancer by CEA and serum enzymes. | The profiles of 4 acute-phase reactant proteins (APRPs) (haptoglobin (HPT), alpha1 antitrypsin (AAT), alpha1 acid glycoprotein (AGP) and prealbumin (PALB)) have been studied during the evolution of bowel cancer. Serial measurements of these APRPs can add to the information obtained from measurements of the level of CEA... | Acute-phase reactant protein profiles: an aid to monitoring large bowel cancer by CEA and serum enzymes. The profiles of 4 acute-phase reactant proteins (APRPs) (haptoglobin (HPT), alpha1 antitrypsin (AAT), alpha1 acid glycoprotein (AGP) and prealbumin (PALB)) have been studied during the evolution of bowel cancer. Ser... | [
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PMID:13806 | Amino acid sequence of the Anthopleura xanthogrammica heart stimulant, anthopleurin A. | A highly potent heart stimulant, anthopleurin A, from Anthopleura xanthogrammica was shown to exist as a single polypeptide chain consisting of 49 amino acid residues. The sequence of the peptide was shown to be: Gly-Val-Ser-Cys-Leu-Cys-Asp-Ser-Asp-Gly-Pro-Ser-Val-Arg-Gly-Asn-Thr-Leu-Ser-Gly-Thr-Leu-Trp-Leu-Tyr-Pro-Ser... | Amino acid sequence of the Anthopleura xanthogrammica heart stimulant, anthopleurin A. A highly potent heart stimulant, anthopleurin A, from Anthopleura xanthogrammica was shown to exist as a single polypeptide chain consisting of 49 amino acid residues. The sequence of the peptide was shown to be: Gly-Val-Ser-Cys-Leu-... | [
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PMID:13807 | Magnetic resonance studies of the binding of 13C-labeled carbon monoxide to myoglobins and hemoglobins containing modified hemes. | The effects of changes in the groups attached to the periphery of the porphyrin ring of the heme of various hemoglobin and myoglobins on the environment experienced by the ligand, carbon monoxide, have been studied by observation of the chemical shift of the bound 13CO. The results indicate that the major interaction b... | Magnetic resonance studies of the binding of 13C-labeled carbon monoxide to myoglobins and hemoglobins containing modified hemes. The effects of changes in the groups attached to the periphery of the porphyrin ring of the heme of various hemoglobin and myoglobins on the environment experienced by the ligand, carbon mon... | [
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PMID:13808 | Correlation between the exposure of aromatic chromophores at the surface of the Fc domains of immunoglobulin G and their ability to bind complement. | The recognition that certain biological effector functions associated with the Fc region of human IgG are mediated exclusively by either the Cgamma2 or Cgamma3 domains prompted a study of some of the physical properties of the isolated domains in an attempt to correlate these with functional differentiation. The degree... | Correlation between the exposure of aromatic chromophores at the surface of the Fc domains of immunoglobulin G and their ability to bind complement. The recognition that certain biological effector functions associated with the Fc region of human IgG are mediated exclusively by either the Cgamma2 or Cgamma3 domains pro... | [
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PMID:13802 | [Further remarks on histochemistry applied to myodiagnosis: findings of "type predominance" (author's transl)]. | Data concerning muscular biopsies (histochemically examined) of three patients affected by Charcot-Marie-Tooth disease, neurogenic atrophy of spondilosic origin and benign congenital hypotonia, are described. The common finding was a histochemical appearence of "type predominance". This point and the possible "neurogen... | [Further remarks on histochemistry applied to myodiagnosis: findings of "type predominance" (author's transl)]. Data concerning muscular biopsies (histochemically examined) of three patients affected by Charcot-Marie-Tooth disease, neurogenic atrophy of spondilosic origin and benign congenital hypotonia, are described.... | [
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PMID:13809 | Purification and properties of debranching enzyme from dogfish muscle. | Glycogen debranching enzyme (4-alpha-glucanotransferase amylo-1,6-glucosidase, EC 2.4.1.25 + 3.2.1.33) was purified 140-fold from dogfish muscle in a rapid, high-yield procedure that takes advantage of a strong binding of the enzyme to glycogen, and its quantitative adsorption to concanavalin A-Sepharose only when the ... | Purification and properties of debranching enzyme from dogfish muscle. Glycogen debranching enzyme (4-alpha-glucanotransferase amylo-1,6-glucosidase, EC 2.4.1.25 + 3.2.1.33) was purified 140-fold from dogfish muscle in a rapid, high-yield procedure that takes advantage of a strong binding of the enzyme to glycogen, and... | [
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PMID:13810 | Mechanism of pigeon liver malic enzyme: kinetics, specificity, and half-site stoichiometry of the alkylation of a cysteinyl residue by the substrate-inhibitor bromopyruvate. | Malic enzyme from pigeon liver is alkylated by the substrate analogue bromopyruvate, resulting in the concomitant loss of its oxidative decarboxylase and oxalacetate decarboxylase activities, but not its ability to reduce alpha-keto acids. The inactivation of oxidative decarboxylase activity follows saturation kinetics... | Mechanism of pigeon liver malic enzyme: kinetics, specificity, and half-site stoichiometry of the alkylation of a cysteinyl residue by the substrate-inhibitor bromopyruvate. Malic enzyme from pigeon liver is alkylated by the substrate analogue bromopyruvate, resulting in the concomitant loss of its oxidative decarboxyl... | [
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PMID:13811 | Mechanism of mitochondrial carbamoyl-phosphate synthetase: synthesis and properties of active CO2, precursor of carbamoyl phosphate. | This paper demonstrates the formation of "active CO2" (CO2-P), a precursor of carbamoyl phosphate (CP), with frog liver carbamoyl-phosphate synthetase. Absence of ammonia is essential for the demonstration by pulse incubation with H14CO3- of CO2-P. Adenosine triphosphate (ATP) and acetylglutamate are required for the s... | Mechanism of mitochondrial carbamoyl-phosphate synthetase: synthesis and properties of active CO2, precursor of carbamoyl phosphate. This paper demonstrates the formation of "active CO2" (CO2-P), a precursor of carbamoyl phosphate (CP), with frog liver carbamoyl-phosphate synthetase. Absence of ammonia is essential for... | [
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PMID:13812 | PH-induced changes in the reactions controlled by the low- and high-affinity Ca2+-binding sites in sarcoplasmic reticulum. | The effect of pH on the Ca2+-binding sites of high and low affinity, located respectively on the outer and inner surfaces of the sarcoplasmic reticulum membrane, was investigated using intact and leaky sarcoplasmic reticulum vesicles. With the use of intact vesicles, different pH profiles of membrane phosphorylation an... | PH-induced changes in the reactions controlled by the low- and high-affinity Ca2+-binding sites in sarcoplasmic reticulum. The effect of pH on the Ca2+-binding sites of high and low affinity, located respectively on the outer and inner surfaces of the sarcoplasmic reticulum membrane, was investigated using intact and l... | [
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PMID:13813 | Investigation of the open ring form of nicotinamide adenine dinucleotide. | In strong alkali, nicotinamide adenine dinucleotide (NAD+) undergoes a ring opening of the nicotinamide ring. The open form of NAD+, ONAD, has two pKa values at--1.9 and 11.2 and absorbs maximally at 350 nm in its acidic form, at 372 nm in its neutral form, and at 340 nm in its aniomic form. ONAD has the chemical prope... | Investigation of the open ring form of nicotinamide adenine dinucleotide. In strong alkali, nicotinamide adenine dinucleotide (NAD+) undergoes a ring opening of the nicotinamide ring. The open form of NAD+, ONAD, has two pKa values at--1.9 and 11.2 and absorbs maximally at 350 nm in its acidic form, at 372 nm in its ne... | [
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PMID:13814 | Metal site conformational states of vanadyl(IV) human serotransferrin complexes. | This study was undertaken to investigate the conformational states of the two metal sites in the human serum transferrin molecule. The 9.2 GHz electron paramagnetic resonance spectra of frozen solutions of divanadyl(IV) transferrin consist of a superposition of two sets of resonances, A and B, due to the magnetically n... | Metal site conformational states of vanadyl(IV) human serotransferrin complexes. This study was undertaken to investigate the conformational states of the two metal sites in the human serum transferrin molecule. The 9.2 GHz electron paramagnetic resonance spectra of frozen solutions of divanadyl(IV) transferrin consist... | [
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0.009726... |
PMID:13815 | Isolation, characterization, and activation of the magnesium dependent endodeoxyribonuclease from Bacillus subtilis. | A major endodeoxyribonulcease was isolated from a mutant of the transformable Bacillus subtilis 168. The magnesium-dependent endonuclease was purified approximately 750-fold to electrophoretic homogeneity. The enzyme had a molecular weight of about 31 000, as determined by gel filtration and polyacrylamide gel electrop... | Isolation, characterization, and activation of the magnesium dependent endodeoxyribonuclease from Bacillus subtilis. A major endodeoxyribonulcease was isolated from a mutant of the transformable Bacillus subtilis 168. The magnesium-dependent endonuclease was purified approximately 750-fold to electrophoretic homogeneit... | [
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PMID:13816 | Mechanism of lysozyme catalysis: role of ground-state strain in subsite D in hen egg-white and human lysozymes. | The association constants for the binding of various saccharides to hen egg-white lysozyme and human lysozyme have been measured by fluorescence titration. Among these are the oligosaccharides GlcNAc-beta(1 leads to 4)-MurNAc-beta(1 leads to 4)-GlcNAc-beta(1 leads to 4)-GlcNAc, GlcNAc-beta(1 leads to 4)-MurNAc-beta(1 l... | Mechanism of lysozyme catalysis: role of ground-state strain in subsite D in hen egg-white and human lysozymes. The association constants for the binding of various saccharides to hen egg-white lysozyme and human lysozyme have been measured by fluorescence titration. Among these are the oligosaccharides GlcNAc-beta(1 l... | [
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0.035612307488918304,
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0.05424... |
PMID:13817 | Energetics of the cooperative and noncooperative binding of nicotinamide adenine dinucleotide to yeast glyceraldehyde-3-phosphate dehydrogenase at pH 6.5 and pH 8.5. Equilibrium and calorimetric analysis over a range of temperature. | The binding of nicotinamide adenine dinucleotide (NAD+) to yeast glyceraldehyde-3-phosphate dehydrogenase (GPDH) has been studied at pH 6.5 and 8.5, at 5,25, and 40 degrees C, by calorimetry, fluorometry, spectrophotometry, equilibrium dialysis, and flow dialysis. As reported earlier for pH 7.3 (Velick S.F., Baggott, J... | Energetics of the cooperative and noncooperative binding of nicotinamide adenine dinucleotide to yeast glyceraldehyde-3-phosphate dehydrogenase at pH 6.5 and pH 8.5. Equilibrium and calorimetric analysis over a range of temperature. The binding of nicotinamide adenine dinucleotide (NAD+) to yeast glyceraldehyde-3-phosp... | [
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PMID:13818 | Interaction of acetazolamide and 4-nitrothiophenolate ion with bivalent metal ion derivatives of bovine carbonic anhydrase. | The stability and rate constants for the interaction of acetazolamide (diamox) and 4-nitrothiophenolate ion (NTP) with the bivalent Mn, Co, Ni, Cu and Cd forms of bovine carbonic anhydrase have been measured by utilizing the distinct visible spectra of each metalloenzyme-NTP adduct. Differing stabilities of the various... | Interaction of acetazolamide and 4-nitrothiophenolate ion with bivalent metal ion derivatives of bovine carbonic anhydrase. The stability and rate constants for the interaction of acetazolamide (diamox) and 4-nitrothiophenolate ion (NTP) with the bivalent Mn, Co, Ni, Cu and Cd forms of bovine carbonic anhydrase have be... | [
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0.018319565802812576,
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-0.016755372285842896,
0.0... |
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