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PMID:14239 | Evaluating the nonverbal communication skills of nursing students. | This study examined the accuracy rate of judging nonverbal skills used by nursing students in communicating with patients. Self-ratings of the students were compared with composite instructor ratings to find areas of disagreement regarding the quality of the nonverbal skills. Students who rated their nonverbal acuity h... | Evaluating the nonverbal communication skills of nursing students. This study examined the accuracy rate of judging nonverbal skills used by nursing students in communicating with patients. Self-ratings of the students were compared with composite instructor ratings to find areas of disagreement regarding the quality o... | [
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PMID:14240 | The effects of feeding on arterial blood gases and lung mechanics in newborn infants recovering from respiratory disease. | Fifteen infants recovering from neonatal respiratory disease had arterial blood gases and lung mechanics measured 5 minutes before bolus feeds and at 5, 10, 20, and 30 minutes after feeding to determine physiologic effects of feeding. PaO2 fell significantly from prefeeding values at 5, 10, and 20 minutes after feeds. ... | The effects of feeding on arterial blood gases and lung mechanics in newborn infants recovering from respiratory disease. Fifteen infants recovering from neonatal respiratory disease had arterial blood gases and lung mechanics measured 5 minutes before bolus feeds and at 5, 10, 20, and 30 minutes after feeding to deter... | [
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PMID:14241 | Efficacy of caffeine in treatment of apnea in the low-birth-weight infant. | The efficacy of caffeine citrate in the management of apnea in the newborn infant was evaluated. Caffeine citrate was given to 18 preterm neonates with recurrent apneic spells. Mean (+/- SE) birth weight and gestational age were 1,065.0 +/- 71.9 gm and 27.5 +/- 0.6 weeks, respectively. Mean age at onset of apnea and at... | Efficacy of caffeine in treatment of apnea in the low-birth-weight infant. The efficacy of caffeine citrate in the management of apnea in the newborn infant was evaluated. Caffeine citrate was given to 18 preterm neonates with recurrent apneic spells. Mean (+/- SE) birth weight and gestational age were 1,065.0 +/- 71.9... | [
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PMID:14242 | Nucleophilic addition of bisulfite ion to prostaglandins E2 and A2: implication in aqueous stability. | Evidence is presented to indicate that the bisulfite ion (HSO3-) adds across the C-9 carbonyl group of dinoprostone (prostaglandin E2) and across the delta 10,11- bond of prostaglandin A2. At room temperature, the apparent equilibrium constant, determined by phase solubility analysis, circular dichroism, UV spectroscop... | Nucleophilic addition of bisulfite ion to prostaglandins E2 and A2: implication in aqueous stability. Evidence is presented to indicate that the bisulfite ion (HSO3-) adds across the C-9 carbonyl group of dinoprostone (prostaglandin E2) and across the delta 10,11- bond of prostaglandin A2. At room temperature, the appa... | [
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PMID:14243 | Use of microcapsules as timed-release parenteral dosage form: application as radiopharmaceutical imaging agent. | The development of a new type of parenteral dosage form is described. A system of microencapsulation was formulated which produced microcapsules containing a water-soluble core material. The basic microencapsulation system could be altered to produce microcapsules with varied timed-release characteristics. Tracer metho... | Use of microcapsules as timed-release parenteral dosage form: application as radiopharmaceutical imaging agent. The development of a new type of parenteral dosage form is described. A system of microencapsulation was formulated which produced microcapsules containing a water-soluble core material. The basic microencaps... | [
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PMID:14244 | Oxidation photosensitized by tetracyclines. | Irradiation with 365-nm UV light of aerated aqueous solutions of tetracycline gives rise to oxygen uptake when the pH of the solution is above 7.5. The kinetics of the reaction were followed using a polarographic oxygen electrode at a range of pH values for seven currently prescribed tetracyclines. Variation of tetracy... | Oxidation photosensitized by tetracyclines. Irradiation with 365-nm UV light of aerated aqueous solutions of tetracycline gives rise to oxygen uptake when the pH of the solution is above 7.5. The kinetics of the reaction were followed using a polarographic oxygen electrode at a range of pH values for seven currently pr... | [
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PMID:14245 | Chemical ionization mass spectra of phenothiazine derivatives and their oxygenated analogs. | Twenty-nine derivatives of phenothiazine formed relatively stable ions by proton capture under conditions of chemical ionization, using methane or isobutane as reagent gas. Fragments of generally low abundance formed by simple bond cleavage in the trimethylene portion of the side chain and by loss of water or hydrogen ... | Chemical ionization mass spectra of phenothiazine derivatives and their oxygenated analogs. Twenty-nine derivatives of phenothiazine formed relatively stable ions by proton capture under conditions of chemical ionization, using methane or isobutane as reagent gas. Fragments of generally low abundance formed by simple b... | [
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PMID:14246 | Effect of chloroquine adsorption on acid reactivity of magnesium trisilicate. | Due to the adsorption of chloroquine by magnesium trisilicate, both the BP acid absorption test and the rate of hydrochloric acid uptake, as monitored by pH measurements, were significantly reduced. This reduction was dependent on the amount of chloroquine adsorbed, since multilayer adsorption produced relatively more ... | Effect of chloroquine adsorption on acid reactivity of magnesium trisilicate. Due to the adsorption of chloroquine by magnesium trisilicate, both the BP acid absorption test and the rate of hydrochloric acid uptake, as monitored by pH measurements, were significantly reduced. This reduction was dependent on the amount ... | [
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PMID:14248 | Prenatal administration of levorphanol or dextrorphan to the rat: analgesic effect of morphine in the offspring. | We have recently demonstrated that prenatal administration of morphine to the rat results in tolerance to the analgesic effects of morphine in the offspring at 3 to 11 weeks of age. To extend these findings, levorphanol or dextrorphan was administered to female CFE rats during days 5 to 12 of gestation. Control animals... | Prenatal administration of levorphanol or dextrorphan to the rat: analgesic effect of morphine in the offspring. We have recently demonstrated that prenatal administration of morphine to the rat results in tolerance to the analgesic effects of morphine in the offspring at 3 to 11 weeks of age. To extend these findings,... | [
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PMID:14249 | Effects of maternal ethanol ingestion on amine uptake into synaptosomes of fetal and neonatal rat brain. | Pregnant rats were kept on an ethanol-containing (6.8% v/v) liquid diet either from the 13th or 18th day of gestation. In pups exposed to ethanol from the 13th day of gestation, synaptosomal uptake of 3H-tyramine and its conversion to 3H-octopamine were increased initially and exposure to ethanol from the 18th day of g... | Effects of maternal ethanol ingestion on amine uptake into synaptosomes of fetal and neonatal rat brain. Pregnant rats were kept on an ethanol-containing (6.8% v/v) liquid diet either from the 13th or 18th day of gestation. In pups exposed to ethanol from the 13th day of gestation, synaptosomal uptake of 3H-tyramine an... | [
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PMID:14250 | Saluretic and uricosuric effects of (6, 7-dichloro-2-methyl=1-oxo-2-phenyl-5-indanyloxy) acetic acid (MK-196) in the chimpanzee. | The saluretic and uricosuric responses elicited by a novel agent, MK-196, have been studied in a great ape, the chimpanzee. This agent is orally active at very low doses and has a prolonged duration of action. Probenecid does not appear to influence the saluretic and uricosuric properties of MK-196. Net tubular secreti... | Saluretic and uricosuric effects of (6, 7-dichloro-2-methyl=1-oxo-2-phenyl-5-indanyloxy) acetic acid (MK-196) in the chimpanzee. The saluretic and uricosuric responses elicited by a novel agent, MK-196, have been studied in a great ape, the chimpanzee. This agent is orally active at very low doses and has a prolonged d... | [
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PMID:14251 | Renal excretion of a slauretic-uricosuric agent (MK-196) and interaction with a urate-retaining drug, pyrazinoate, in the chimpanzee. | The excretory pattern for MK-196 is ocmpatible with that of other weak organic acids such as salicylate and probenecid. Tubular secretion of MK-196 is strongly inhibitied by probenecid and high loads of p-aminohippurate. Urinary excretion of MK-196 is increased 10-fold when the urine is alkaline. Clearances of MK-196 w... | Renal excretion of a slauretic-uricosuric agent (MK-196) and interaction with a urate-retaining drug, pyrazinoate, in the chimpanzee. The excretory pattern for MK-196 is ocmpatible with that of other weak organic acids such as salicylate and probenecid. Tubular secretion of MK-196 is strongly inhibitied by probenecid a... | [
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PMID:14255 | Potential difference and the distribution of ions across the human red blood cell membrane; a study of the mechanism by which the fluorescent cation, diS-C3-(5) reports membrane potential. | 1. The mechanism by which the fluorescent, cationic dye diS-C3-(5) responds to the membrane potential of red blood cells has been investigated. 2. The dye in aqueous solution absorbs most strongly at 650 nm. Addition of white, haemoglobin-free membranes red shifts the absorption maximum ca. 20 nm, while addition of mem... | Potential difference and the distribution of ions across the human red blood cell membrane; a study of the mechanism by which the fluorescent cation, diS-C3-(5) reports membrane potential. 1. The mechanism by which the fluorescent, cationic dye diS-C3-(5) responds to the membrane potential of red blood cells has been i... | [
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PMID:14256 | The Bohr effect on the reaction of carbon monoxide with fully oxygenated haemoglobin. | 1. The rate at which CO displaces O2 from its combination with haemoglobin in solution, has been measured spectrophotometrically, using a rapid-mixing stopped-flow technique. 2. In the presence of CO2, the reaction proceeds by a unimolecular dissociation, with a rate constant r. 3. The relationship of the reciprocal of... | The Bohr effect on the reaction of carbon monoxide with fully oxygenated haemoglobin. 1. The rate at which CO displaces O2 from its combination with haemoglobin in solution, has been measured spectrophotometrically, using a rapid-mixing stopped-flow technique. 2. In the presence of CO2, the reaction proceeds by a unimo... | [
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PMID:14259 | Interprofessional education of the new health practitioner. | This is a report of a survey of the interprofessional education activities included in 54 physician's assistant and 60 nurse practitioner programs. In a majority of such new health practitioner programs, the importance of interprofessional education as a part of training for team health care delivery has been recognize... | Interprofessional education of the new health practitioner. This is a report of a survey of the interprofessional education activities included in 54 physician's assistant and 60 nurse practitioner programs. In a majority of such new health practitioner programs, the importance of interprofessional education as a part ... | [
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PMID:14265 | Role of bacterial microflora in development of intestinal lesions from graft-versus-host reaction. | Acute secondary disease was induced in (C57BL X CBA)F1 mice by transplanting CBA bone marrow and spleen cells following lethal whole-body irradiation. The lesions of graft-versus-host (GvH) disease were scored quantitatively by counting of degenerated crypts in subcutaneous fetal gut implants that were free of bacteria... | Role of bacterial microflora in development of intestinal lesions from graft-versus-host reaction. Acute secondary disease was induced in (C57BL X CBA)F1 mice by transplanting CBA bone marrow and spleen cells following lethal whole-body irradiation. The lesions of graft-versus-host (GvH) disease were scored quantitativ... | [
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PMID:14266 | Observations upon calcium oxalate crystallization kinetics in simulated urine. | Two major etiologic theories of urinary stones are excessive saturation of urine with crystallizable substances or defects in inhibitors that allow relative supersaturation to occur. To date, it has been difficult to confirm the supersaturation theory in experiments using diffusion-limited crystallization systems becau... | Observations upon calcium oxalate crystallization kinetics in simulated urine. Two major etiologic theories of urinary stones are excessive saturation of urine with crystallizable substances or defects in inhibitors that allow relative supersaturation to occur. To date, it has been difficult to confirm the supersaturat... | [
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PMID:14268 | [Bacteriological evaluation of clindamycin-2-phosphate (author's transl)]. | Clindamycin-2-phosphate, a newly developed injectable antibiotic, was bacteriologically evaluated in comparison with the parent compound, clindamycin. Clindamycin-2-phosphate has a rather weak antibacterial activity. However, it is metabolized into clindamycin in vivo. And this parent compound shows strong activity aga... | [Bacteriological evaluation of clindamycin-2-phosphate (author's transl)]. Clindamycin-2-phosphate, a newly developed injectable antibiotic, was bacteriologically evaluated in comparison with the parent compound, clindamycin. Clindamycin-2-phosphate has a rather weak antibacterial activity. However, it is metabolized i... | [
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PMID:14269 | [Use of clindamycin-2-phosphate in ophthalmology (author's transl)]. | Clindamycin-2-phosphate was studied to evaluate its possible use in ophthalmology. 1. Sensitivity of organisms isolated from human clinical materials: Of 44 staphylococcal strains in vitro studied 13 were highly sensitive to 0.1 mug/ml and 28 were resistant to 100 mug/ml or more of clindamycin-2-phosphate. 2. In experi... | [Use of clindamycin-2-phosphate in ophthalmology (author's transl)]. Clindamycin-2-phosphate was studied to evaluate its possible use in ophthalmology. 1. Sensitivity of organisms isolated from human clinical materials: Of 44 staphylococcal strains in vitro studied 13 were highly sensitive to 0.1 mug/ml and 28 were res... | [
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PMID:14270 | Experimental models for prevention of graft-versus-host reaction in bone marrow transfusion. I. Selective suppression and augmentation of splenomegaly and cytotoxicity. | Induction and suppression of splenomegaly and cytotoxicity against C57BL/L cells were studied in (AKR X C57BL/6) F1 hybrid adult mice after the transfer of AKR lymphoid and bone marrow cells. 1) Splenomegaly and cytotoxicity were dissociated in the developmental stages of the graft-versus-host reaction. When lymphoid a... | Experimental models for prevention of graft-versus-host reaction in bone marrow transfusion. I. Selective suppression and augmentation of splenomegaly and cytotoxicity. Induction and suppression of splenomegaly and cytotoxicity against C57BL/L cells were studied in (AKR X C57BL/6) F1 hybrid adult mice after the transfe... | [
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PMID:14271 | Germination of unactivated spores of Bacillus cereus T. Effect of preincubation with L-alanine or inosine on the subsequent germination. | Heat-activated spores of Bacillus cereus T germinate rapidly in the presence of L-alanine alone or inosine alone. In contrast, unactivated spores can not germinate in the presence of either germinant alone but rapidly in the presence of both germinants. The highest level of cooperative action of L-alanine and inosine o... | Germination of unactivated spores of Bacillus cereus T. Effect of preincubation with L-alanine or inosine on the subsequent germination. Heat-activated spores of Bacillus cereus T germinate rapidly in the presence of L-alanine alone or inosine alone. In contrast, unactivated spores can not germinate in the presence of ... | [
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PMID:14273 | Iron poisoning. | Based on the metabolism, pathophysiology and clinical picture of iron poisoning, a treatment protocol for the emergency department is presented. For insignificant amounts, treatment is ipecac and oral bicarbonate. For ingestions of amounts greater than 150 mg/kg, even if the patient is asymptomatic, hospital observatio... | Iron poisoning. Based on the metabolism, pathophysiology and clinical picture of iron poisoning, a treatment protocol for the emergency department is presented. For insignificant amounts, treatment is ipecac and oral bicarbonate. For ingestions of amounts greater than 150 mg/kg, even if the patient is asymptomatic, hos... | [
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PMID:14275 | [Bone marrow transplanation by aplastic anemia and acute leukemia--chances, success, indications (author's transl)]. | The experimental background, methods of preventing immunological complications and clinical results of bone marrow transplantation in cases with aplastic anemia and acute leukemia in relapse are reported. The causes for failure in clinical bone marrow transplantation insert: are discussed. The possibilities of bone mar... | [Bone marrow transplanation by aplastic anemia and acute leukemia--chances, success, indications (author's transl)]. The experimental background, methods of preventing immunological complications and clinical results of bone marrow transplantation in cases with aplastic anemia and acute leukemia in relapse are reported... | [
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PMID:14276 | [Long space flights and the human habitat]. | The paper discusses the generation of an environment which may adequately meet human requirements that have developed as a result of evolution in the Earth biosphere as applied to long-duration manned space flights. This environment must exert functional effects on physiological systems of the human body which appear t... | [Long space flights and the human habitat]. The paper discusses the generation of an environment which may adequately meet human requirements that have developed as a result of evolution in the Earth biosphere as applied to long-duration manned space flights. This environment must exert functional effects on physiologi... | [
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PMID:14279 | Otitis media of guinea pigs. | Otitis media occurred in 177 of 1373 guinea pigs necropsied during a six-year period. Streptococcus pneumoniae (20%), Streptococcus zooepidemicus (15%), Bordetella bronchiseptica (12%), and Pseudomonas aeruginosa (11%) were the most common bacteria isolated from affected tympanic bullae. Radiology and otoscopy were tes... | Otitis media of guinea pigs. Otitis media occurred in 177 of 1373 guinea pigs necropsied during a six-year period. Streptococcus pneumoniae (20%), Streptococcus zooepidemicus (15%), Bordetella bronchiseptica (12%), and Pseudomonas aeruginosa (11%) were the most common bacteria isolated from affected tympanic bullae. Ra... | [
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PMID:14277 | [Patterns in the change in the body state of dogs during a breakdown of the atmosphere regeneration system in a pressurized space]. | Experiments were carried out on dogs kept in a sealed chamber. Changes in the O2 and CO2 concentrations as well as variations of physiological functions, the so-called survival curves, were studied under the conditions of terminated O2 supply and CO2 utilization. The criteria of investigation, mathematical and physiolo... | [Patterns in the change in the body state of dogs during a breakdown of the atmosphere regeneration system in a pressurized space]. Experiments were carried out on dogs kept in a sealed chamber. Changes in the O2 and CO2 concentrations as well as variations of physiological functions, the so-called survival curves, wer... | [
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PMID:14282 | Effects of ventricular fibrillation on coronary blood flow and myocardial metabolism. | Ventricular fibrillation is frequently induced during cardiac surgery to quiet the operative field. The reported effects of fibrillation on the myocardium vary considerably. In an attempt to better define these effects, we subjected 28 dogs to one hour of total normothermic bypass. Myocardial blood flow, lactate, adeno... | Effects of ventricular fibrillation on coronary blood flow and myocardial metabolism. Ventricular fibrillation is frequently induced during cardiac surgery to quiet the operative field. The reported effects of fibrillation on the myocardium vary considerably. In an attempt to better define these effects, we subjected 2... | [
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PMID:14295 | Arterialized capillary blood gases in exercise studies. | The PCO2, PO2 and pH of arterial blood and arterialized capillary blood from the ear lobe were compared in 13 patients at rest and during submaximal exercise. The mean capillary PCO2 was .6 mmHg lower than arterial PCO2 at rest and 1 mmHg lower in exercise. The variation in comparisons (S.D. 1.4 mmHg) at rest and exerc... | Arterialized capillary blood gases in exercise studies. The PCO2, PO2 and pH of arterial blood and arterialized capillary blood from the ear lobe were compared in 13 patients at rest and during submaximal exercise. The mean capillary PCO2 was .6 mmHg lower than arterial PCO2 at rest and 1 mmHg lower in exercise. The va... | [
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PMID:14297 | [Intragastric titration with extragastric pH-metry--a clinically applicable and reliable technique of quantitative analysis of gastric secretion (author's transl)]. | A technique is described by which the secretory capacity of the stomach can be determined. It appears to be superior both to intragastric titration along with intragastric pH-metry and to common analysis of gastric juice obtained by aspiration. There is no essential difference when comparing results obtained intraindiv... | [Intragastric titration with extragastric pH-metry--a clinically applicable and reliable technique of quantitative analysis of gastric secretion (author's transl)]. A technique is described by which the secretory capacity of the stomach can be determined. It appears to be superior both to intragastric titration along w... | [
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PMID:14294 | The Asian species of strychnos. Part IV. The alkaloids. | Two hundred thirty-four samples from thirty-six Asian species of Strychnos have been screened for the presence of tertiary alkaloids; the data are set out in table 1. Thin-layer and gas-liquid chromatographic as well as mass-spectrometric studies have enabled alkaloids to be identified in many of the extracts prepared;... | The Asian species of strychnos. Part IV. The alkaloids. Two hundred thirty-four samples from thirty-six Asian species of Strychnos have been screened for the presence of tertiary alkaloids; the data are set out in table 1. Thin-layer and gas-liquid chromatographic as well as mass-spectrometric studies have enabled alka... | [
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PMID:14299 | [Spermatogonia counts in descended and undescended prebuberal testes (author's transl)]. | The following conclusions which show the importance of time of medical treatment resulted from the examination of 288 testicular biopsies (including 46 controls) by statistical analysis in correlation to age. 1. There is no difference in the number of spermatogonia per tubule cross section of descended and undescended ... | [Spermatogonia counts in descended and undescended prebuberal testes (author's transl)]. The following conclusions which show the importance of time of medical treatment resulted from the examination of 288 testicular biopsies (including 46 controls) by statistical analysis in correlation to age. 1. There is no differe... | [
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PMID:14303 | [Chemical modification of proteins. 2. Blocking of amino groups and basic amino acids and crosslinking of polypeptide chains in casein and field bean globulin by reaction with dialdehyde starch]. | The reaction of dialdehyde starch with casein and field-bean globulin leads to a blocking of the protein amino groups and to a decrease of free lysine, arginine and histidine. Maximum values are reached at high protein concentrations and great molar reagent excess. At best 80-93% of the amino groups or of the available... | [Chemical modification of proteins. 2. Blocking of amino groups and basic amino acids and crosslinking of polypeptide chains in casein and field bean globulin by reaction with dialdehyde starch]. The reaction of dialdehyde starch with casein and field-bean globulin leads to a blocking of the protein amino groups and to... | [
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PMID:14304 | Signs, symptoms, and pathophysiology of Pneumocystis carinii pneumonitis. | In 80 patients with Pneumocystis pneumonitis, the intial signs and symptoms of infection were usually fever and cough, followed by tachypnea and coryza. Flaring of the nasal alae and cyanosis occurred later. Blood gas composition was markedly altered in its acid-base profile in most patients at admission. There was mod... | Signs, symptoms, and pathophysiology of Pneumocystis carinii pneumonitis. In 80 patients with Pneumocystis pneumonitis, the intial signs and symptoms of infection were usually fever and cough, followed by tachypnea and coryza. Flaring of the nasal alae and cyanosis occurred later. Blood gas composition was markedly alt... | [
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PMID:14305 | Relaxation of heart muscle by catecholamines and by dibutyryl cyclic adenosine 3',5'-monophosphate. Similarity of beta-adrenoceptors mediating contractile and relaxant effects of catecholamines in kitten pipillary muscle. | 1. In isometrically contracting kitten papillary muscles, dibutyryl cyclic AMP (DBcAMP) enhanced peak tension, increased rates of contraction and relaxation, decreased tension of a phasic but not of a small tonic component of KCl-contractures, and caused aftercontractions. These effects resemble closely those of catech... | Relaxation of heart muscle by catecholamines and by dibutyryl cyclic adenosine 3',5'-monophosphate. Similarity of beta-adrenoceptors mediating contractile and relaxant effects of catecholamines in kitten pipillary muscle. 1. In isometrically contracting kitten papillary muscles, dibutyryl cyclic AMP (DBcAMP) enhanced p... | [
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PMID:14306 | Activation of myocardial beta-adrenoceptors by the nitrogen-free low affinity ligand 3',4'-dihydroxy-alpha-methylpropiophenone (U-0521). | The effect of 3',4'-dihydroxy-alpha-methylpropiophenone (U-0521) on the rate of spontaneously contracting cultured rat heart cells and right atria of rats and kittens was investigated. The action of U-0521 on the cellular content of cyclic AMP and on the adenylyl cyclase of heart membrane particels was also studied. 1.... | Activation of myocardial beta-adrenoceptors by the nitrogen-free low affinity ligand 3',4'-dihydroxy-alpha-methylpropiophenone (U-0521). The effect of 3',4'-dihydroxy-alpha-methylpropiophenone (U-0521) on the rate of spontaneously contracting cultured rat heart cells and right atria of rats and kittens was investigated... | [
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PMID:14307 | Central sites and mechanisms of the hypotensive and bradycardic effects of the narcotic analgesic agent fentanyl. | In dogs, anaesthetized with chloralose, fentanyl (5 mug/kg i.v.) augmented the bradycardia produced by electrical stimulation of the carotid sinus nerves. In contrast, the same dose of the drug did not change the bradycardic response to stimulation of the nucleus of the solitary tract (NTS) indicating that a central fa... | Central sites and mechanisms of the hypotensive and bradycardic effects of the narcotic analgesic agent fentanyl. In dogs, anaesthetized with chloralose, fentanyl (5 mug/kg i.v.) augmented the bradycardia produced by electrical stimulation of the carotid sinus nerves. In contrast, the same dose of the drug did not chan... | [
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PMID:14308 | The in vitro secretion of epidermal growth factor by mouse submandibular salivary gland. | A technique for the study of epidermal growth factor (EGF) secretion from salivary gland pieces in vitro is described and the responses to a variety of drugs are compared to the results of previously reported in vivo studies. Adrenaline stimulates secretion of the growth factor as does the alpha-adrenergic agonist phen... | The in vitro secretion of epidermal growth factor by mouse submandibular salivary gland. A technique for the study of epidermal growth factor (EGF) secretion from salivary gland pieces in vitro is described and the responses to a variety of drugs are compared to the results of previously reported in vivo studies. Adren... | [
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PMID:14309 | Effect of passages of Morris hepatoma 5123D in F1 (Buffalo X Wistar) rats on permanent decrease of gamma-glutamyltranspeptidase activity. | The Morris hepatoma 5123D after at least two passages in F1 (Buffalo X Wistar) rats shows quicker growth than the original tumor and bearers of it have much lower gamma-glutamyltranspeptidase activity in serum, urine, tumor and in some other organs. This new variant of the hepatoma was labeled as hepatoma 5123D/AS. Sim... | Effect of passages of Morris hepatoma 5123D in F1 (Buffalo X Wistar) rats on permanent decrease of gamma-glutamyltranspeptidase activity. The Morris hepatoma 5123D after at least two passages in F1 (Buffalo X Wistar) rats shows quicker growth than the original tumor and bearers of it have much lower gamma-glutamyltrans... | [
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PMID:14311 | [Dynamics of synaptic changes in experimental audiogenic epilepsy]. | The dynamics of ultrastructural changes in axonal endings were studied after experimental epileptic seizures. Mice and rats from strains with genetically--determined audiogenic epilepsy were used as a model of epilepsy. The animals were divided into 3 groups: in group 1 only one seizure was evoked, in group 2 eight sei... | [Dynamics of synaptic changes in experimental audiogenic epilepsy]. The dynamics of ultrastructural changes in axonal endings were studied after experimental epileptic seizures. Mice and rats from strains with genetically--determined audiogenic epilepsy were used as a model of epilepsy. The animals were divided into 3 ... | [
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PMID:14317 | [New preparation with antalgic sedative and anxiolytic activity in manifestations of interest to internal medicine. Double-blind controlled clinical study]. | A controlled double-blind clinical trial using randomised blocks was carried out on 3 groups of 10 patients with internal diseases and a pain syndrome accompanied by anxiety. One group received the product under examination (FC 35aA) and the other two its components (dipotassic chlorazepate, paracetamol and codeine). F... | [New preparation with antalgic sedative and anxiolytic activity in manifestations of interest to internal medicine. Double-blind controlled clinical study]. A controlled double-blind clinical trial using randomised blocks was carried out on 3 groups of 10 patients with internal diseases and a pain syndrome accompanied ... | [
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PMID:14320 | Some studies in an institution for the mentally retarded. | Patient characteristics and psychotropic drug use in a hospital for the mentally retarded were studied. The majority of patients appeared permanent, 80 percent having been there five years. Ages ranged from 2 to 71 years. Most were mildly or moderately retarded. Fifty-five percent had been originally domiciled within t... | Some studies in an institution for the mentally retarded. Patient characteristics and psychotropic drug use in a hospital for the mentally retarded were studied. The majority of patients appeared permanent, 80 percent having been there five years. Ages ranged from 2 to 71 years. Most were mildly or moderately retarded.... | [
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PMID:14321 | New Zealand Committee on Adverse Drug Reactions: eleventh annual report 1976. | Under the voluntary reporting scheme 499 cases of adverse drug reaction or reactions were reported. Noteworthy items included immediate hypersensitivity-type reactions to anaesthetic agents, a number of life-threatening reactions to anti-inflammatory drugs, paradoxical increase in blood pressure with high-dose pindolol... | New Zealand Committee on Adverse Drug Reactions: eleventh annual report 1976. Under the voluntary reporting scheme 499 cases of adverse drug reaction or reactions were reported. Noteworthy items included immediate hypersensitivity-type reactions to anaesthetic agents, a number of life-threatening reactions to anti-infl... | [
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PMID:14324 | Flight muscle ultrastructure of susceptible and refractory mosquitoes parasitized by larval Brugia pahangi. | On parasitization with larval Brugia pahangi the infected flight muscle fibres of "resistant" Anopheles labranchiae atroparvus undergo the following ultrastructural changes. The fibres become almost totally devoid of glycogen, their sarcoplasmic reticulum becomes elongate and closely associated with muscle fibrils. The... | Flight muscle ultrastructure of susceptible and refractory mosquitoes parasitized by larval Brugia pahangi. On parasitization with larval Brugia pahangi the infected flight muscle fibres of "resistant" Anopheles labranchiae atroparvus undergo the following ultrastructural changes. The fibres become almost totally devoi... | [
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PMID:14326 | Multiple leukocyte abnormalities in chronic granulomatous disease: a familial study. | A variety of leukocyte enzyme activities were studied in an 11-year-old female with chronic granulomatous disease (CGD) and several members of her family. Leukocyte glucose-6-phosphate dehydrogenase (G-6-PD) activity was 17 nmol/min/mg protein in the patient; two brothers with symptoms of recurrent bacterial infections... | Multiple leukocyte abnormalities in chronic granulomatous disease: a familial study. A variety of leukocyte enzyme activities were studied in an 11-year-old female with chronic granulomatous disease (CGD) and several members of her family. Leukocyte glucose-6-phosphate dehydrogenase (G-6-PD) activity was 17 nmol/min/mg... | [
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PMID:14327 | Fluoresceinylthiocarbamyl-tRNATyr: a useful derivative of tRNATyr (E.coli) for physicochemical studies. | Fluoresceinylthiocarbamyl-tRNATyr (FTC-tRNATyr) is prepared from tRNATyr and fluoresceinisothiogyanate (FITC) under mildly alkaline conditions. Labelling occurs specificly at the base Q of tRNATyr. The modified tRNA is fully active in the aminoacylation assay; when aminoacylated it is recognized by the elongation facto... | Fluoresceinylthiocarbamyl-tRNATyr: a useful derivative of tRNATyr (E.coli) for physicochemical studies. Fluoresceinylthiocarbamyl-tRNATyr (FTC-tRNATyr) is prepared from tRNATyr and fluoresceinisothiogyanate (FITC) under mildly alkaline conditions. Labelling occurs specificly at the base Q of tRNATyr. The modified tRNA ... | [
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PMID:14323 | [Perspectives of use of genetic methods of control of bloodsucking Diptera - vectors of the diseases of man]. | This paper presents genetic methods of control of bloodsucking Diptera, mosquitoes. The perspective of the use of various control methods, first of all those tested under field conditions in application for bloodsuckers which are of medical importance throughout the USSR, is regarded. The opinion is suggested that the ... | [Perspectives of use of genetic methods of control of bloodsucking Diptera - vectors of the diseases of man]. This paper presents genetic methods of control of bloodsucking Diptera, mosquitoes. The perspective of the use of various control methods, first of all those tested under field conditions in application for blo... | [
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PMID:14328 | A 31P-NMR study of the interaction of Mg2+ ions with nucleoside diphosphates. | The interaction of Mg2+ with nucleoside disphosphates : ADP, GDP, CDP and UDP has been studied by phosphorus magnetic resonance spectroscopy in aqueous solution. The results show that these four nucleotides behave similarly, the Mg2+ ion binds to the alpha but not to the beta phosphate moiety. The strength of the inter... | A 31P-NMR study of the interaction of Mg2+ ions with nucleoside diphosphates. The interaction of Mg2+ with nucleoside disphosphates : ADP, GDP, CDP and UDP has been studied by phosphorus magnetic resonance spectroscopy in aqueous solution. The results show that these four nucleotides behave similarly, the Mg2+ ion bind... | [
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PMID:14332 | High-dose treatment with neuroleptics in the acute phase of mental disease. | More than 300 patients have been observed during treatment with either flupenthixol, haloperidol, fluphenazine enanthate or perphenazine enanthate in high doses, whilst suffering from severe mental disease, usually of psychotic nature. Used correctly, high-dose treatment gives a rapid control of psychotic symptoms, an ... | High-dose treatment with neuroleptics in the acute phase of mental disease. More than 300 patients have been observed during treatment with either flupenthixol, haloperidol, fluphenazine enanthate or perphenazine enanthate in high doses, whilst suffering from severe mental disease, usually of psychotic nature. Used cor... | [
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PMID:14338 | Competitive inhibitors of renin. A review. | This review describes some of the characteristics for renin's substrate specificity and also some features of its species specificity. It describes how competitive inhibitors were synthesized and how the solubility was increased in order to make them effective at physiological pH. Their use for in vitro and in vivo inh... | Competitive inhibitors of renin. A review. This review describes some of the characteristics for renin's substrate specificity and also some features of its species specificity. It describes how competitive inhibitors were synthesized and how the solubility was increased in order to make them effective at physiological... | [
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PMID:14340 | Interaction of salicylic acid with adenosine and adenosine triphosphate. Potential mechanism of intensifying acetylsalicylic acid-induced GI blood loss. | Complex formation between salicylic acid and adenosine or adenosine triphosphate in 0.2m phosphate buffer at pH=7 was investigated as a potential factor contributing to the prolongation of acetylsalicylic acid-induced GI blood loss. Spectrophotemetric techniques were used to evalute the complexation. Concerntration dep... | Interaction of salicylic acid with adenosine and adenosine triphosphate. Potential mechanism of intensifying acetylsalicylic acid-induced GI blood loss. Complex formation between salicylic acid and adenosine or adenosine triphosphate in 0.2m phosphate buffer at pH=7 was investigated as a potential factor contributing t... | [
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PMID:14342 | Kinetics and mechanism of degradation of some 5-allylbarbituric acid derivatives. Part 3: Kinetics of solvolysis of major intermediates of 5.5-diallylbarbituric acid degradation. | Solvolysis of N-diallylacetylurea and 5.5-diallylmalonuric acid was investigated in the pH range ca. 8--12 by means of spectrophotometric and t.l.c. methods. Their log k--pH profiles were constructed from the experimental results obtained by degradation at 70 degrees C. Therefore, specific catalytic rate constants and ... | Kinetics and mechanism of degradation of some 5-allylbarbituric acid derivatives. Part 3: Kinetics of solvolysis of major intermediates of 5.5-diallylbarbituric acid degradation. Solvolysis of N-diallylacetylurea and 5.5-diallylmalonuric acid was investigated in the pH range ca. 8--12 by means of spectrophotometric and... | [
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PMID:14346 | Effects of hypolipidemic agents on lipid synthesis in subcellular fractions from Tetrahymena pyriformis. | Lipid synthesizing systems have been prepared from subcellular fractions of Tetrahymena pyriformis, GL. These fractions, the mitochondrial fraction, the microsomal fraction and the soluble cell fraction, have been characterized as to cofactors and cations required for optimal lipid synthesis. The effects of hypolipidem... | Effects of hypolipidemic agents on lipid synthesis in subcellular fractions from Tetrahymena pyriformis. Lipid synthesizing systems have been prepared from subcellular fractions of Tetrahymena pyriformis, GL. These fractions, the mitochondrial fraction, the microsomal fraction and the soluble cell fraction, have been c... | [
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PMID:14347 | Analgesic, heart rate, and temperature effects of delta8-THC during acute and chronic administration to conscious rats. | Acute and chronic effects of delta8-THC on tail-flick, heart rate, and rectal temperature responses in conscious, unrestrained male rats were studied. In the acute experiment unidirectional dose-dependent analgesic, hypothermic, and negative chronotropic cardiac effects were observed within the dose range employed. Of ... | Analgesic, heart rate, and temperature effects of delta8-THC during acute and chronic administration to conscious rats. Acute and chronic effects of delta8-THC on tail-flick, heart rate, and rectal temperature responses in conscious, unrestrained male rats were studied. In the acute experiment unidirectional dose-depen... | [
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PMID:14350 | Efficacy of loxapine in the treatment of paranoid schizophrenia. | A combined analysis of data from 11 controlled studies of loxapine versus either chlorpromazine or trifluoperazine in acute schizophrenia (5 studies) and chronic schizophrenia (6 studies) showed statistically significant superiority of loxapine on several items and factors of standardized psychiatric rating scales. Upo... | Efficacy of loxapine in the treatment of paranoid schizophrenia. A combined analysis of data from 11 controlled studies of loxapine versus either chlorpromazine or trifluoperazine in acute schizophrenia (5 studies) and chronic schizophrenia (6 studies) showed statistically significant superiority of loxapine on several... | [
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PMID:14351 | [Psychopharmacological influence on the prey catching behavior of ferrets (Putorius furo L.) (author's transl)]. | The prey-catching behavior of ferrets (Putorius furo L.) consists mainly of instinctive behavior patterns, which can be elicited only through their releaser. Then they are performed stereotypically. To get information concerning the central background and the hierarchical structure of this behavior the neuroleptics Hal... | [Psychopharmacological influence on the prey catching behavior of ferrets (Putorius furo L.) (author's transl)]. The prey-catching behavior of ferrets (Putorius furo L.) consists mainly of instinctive behavior patterns, which can be elicited only through their releaser. Then they are performed stereotypically. To get i... | [
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PMID:14352 | Effect of flupenthixol and butaclamol isomers on prolactin secretion in rats. | Cis (alpha)-flupenthixol and (+)-butaclamol are effective anti-psychotic agents but trans (beta)-flupenthixol and (-)-butaclamol are not. alpha-Flupenthixol was found to be 245 times more active in elevating rat plasma prolactin than the beta-isomer. The discrepancy between (+)-butaclamol and (-)-butaclamol was even gr... | Effect of flupenthixol and butaclamol isomers on prolactin secretion in rats. Cis (alpha)-flupenthixol and (+)-butaclamol are effective anti-psychotic agents but trans (beta)-flupenthixol and (-)-butaclamol are not. alpha-Flupenthixol was found to be 245 times more active in elevating rat plasma prolactin than the beta... | [
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PMID:14353 | Changes in dopamine synthesis rate in the supersensitivity phase after treatment with a single dose of neuroleptics. | The changes in 14C-dopamine accumulation formed from 14C-tyrosine in mice after treatment with three neuroleptics, cis (Z)-flupenthixol, fluphenazine, and haloperidol, were followed for 6 days. The neuroleptics all changed DA synthesis rate in the same way, initially causing an increase which was followed by a decrease... | Changes in dopamine synthesis rate in the supersensitivity phase after treatment with a single dose of neuroleptics. The changes in 14C-dopamine accumulation formed from 14C-tyrosine in mice after treatment with three neuroleptics, cis (Z)-flupenthixol, fluphenazine, and haloperidol, were followed for 6 days. The neuro... | [
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PMID:14361 | The biosynthesis of dimethyltryptamine in vivo. | The in vivo formation of dimethyltryptamine was studied in rabbits, rats and monkeys. When C14-labelled N-methyltryptamine was administered by intravenous injection to rabbits, C14-dimethyltryptamine was found in lung, the principle site of the methyltransferase that biosynthesizes this psychotogen. Unequivocal evidenc... | The biosynthesis of dimethyltryptamine in vivo. The in vivo formation of dimethyltryptamine was studied in rabbits, rats and monkeys. When C14-labelled N-methyltryptamine was administered by intravenous injection to rabbits, C14-dimethyltryptamine was found in lung, the principle site of the methyltransferase that bios... | [
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PMID:14362 | An improved technique for the preparation of chromosomes from cattle whole blood. | The method of preparation of chromosomes from cattle whole blood is described in detail and has been tested by use on more than 1000 different animal samples. It is shown that elevated levels of glutamine and 1-cystine increase the mitotic index and improve the keeping qualities of the medium 199. The recipe for whole ... | An improved technique for the preparation of chromosomes from cattle whole blood. The method of preparation of chromosomes from cattle whole blood is described in detail and has been tested by use on more than 1000 different animal samples. It is shown that elevated levels of glutamine and 1-cystine increase the mitoti... | [
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PMID:14363 | Blood respiratory properties in the naked mole rat Heterocephalus glaber, a mammal of low body temperature. | Respiratory properties of whole blood and Hb solutions have been studied in Heterocephalus glaber, a fossorial rodent, having a low body temperature (30.0-32.0 degrees C) and poor thermoregulatory ability. For comparison similar, measurements were made on laboratory mice, Mus musculus. Whole blood showed a distinctly h... | Blood respiratory properties in the naked mole rat Heterocephalus glaber, a mammal of low body temperature. Respiratory properties of whole blood and Hb solutions have been studied in Heterocephalus glaber, a fossorial rodent, having a low body temperature (30.0-32.0 degrees C) and poor thermoregulatory ability. For co... | [
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PMID:14364 | The role of brief hypocapnia in the ventilatory response to CO2 with hypoxia. | In conscious cats the ventilatory response curve to physiological range of CO2 is displaced upward by hypoxia (about 45 torr), but it rises, either parallel with, or convergent on, the normoxic curve. Thus, a positive interaction of hypoxia and hypercapnic stimuli is not observed under these circumstances. However, if ... | The role of brief hypocapnia in the ventilatory response to CO2 with hypoxia. In conscious cats the ventilatory response curve to physiological range of CO2 is displaced upward by hypoxia (about 45 torr), but it rises, either parallel with, or convergent on, the normoxic curve. Thus, a positive interaction of hypoxia a... | [
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PMID:14365 | Ventilatory and circulatory O2 convection at 4000 m in pigeon at neutral or cold temperature. | Awake domestic pigeons, either maintained at 22 degrees C (series I) or acutely exposed at 2 degrees C (series II), were studied in a hypobaric chamber at 140 m and at various stages during a 4-week exposure to 4000 m. Steady-state pulmonary ventilation (Vg) and breathing pattern (VT, fr), oxygen consumption (MO2), O2 ... | Ventilatory and circulatory O2 convection at 4000 m in pigeon at neutral or cold temperature. Awake domestic pigeons, either maintained at 22 degrees C (series I) or acutely exposed at 2 degrees C (series II), were studied in a hypobaric chamber at 140 m and at various stages during a 4-week exposure to 4000 m. Steady-... | [
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PMID:14366 | The CSF HCO3 increase in hypercapnia relationshp to HCO3, glutamate, glutamine and NH3 in brain. | To study the role of carbonic anhydrase in the CSF [HCO3] increase in respiratory acidosis and its effect on brain ammonia, anesthetized rats were subjected to hypercapnia (7% CO2) for 2 hours. The animals received periodic intraventricular injections of either 'mock' CSF or 'mock' CSF and acetazolamide for 45 minutes ... | The CSF HCO3 increase in hypercapnia relationshp to HCO3, glutamate, glutamine and NH3 in brain. To study the role of carbonic anhydrase in the CSF [HCO3] increase in respiratory acidosis and its effect on brain ammonia, anesthetized rats were subjected to hypercapnia (7% CO2) for 2 hours. The animals received periodic... | [
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PMID:14392 | Preparation of 125I-labeled synthetic porcine secretin for radioimmunoassay. | Synthetic porcine secretion was labelled by the conjugation-labelling method of Bolton & Hunter, the lactoperoxidase method, the gaseous diffusion method, and the chloramine-T method. The chloramine-T technique was adapted as routine method. Ten mug (3.27 nmol) peptide was reacted with 5 mCi of Na125I at a concentr... | Preparation of 125I-labeled synthetic porcine secretin for radioimmunoassay. Synthetic porcine secretion was labelled by the conjugation-labelling method of Bolton & Hunter, the lactoperoxidase method, the gaseous diffusion method, and the chloramine-T method. The chloramine-T technique was adapted as routine metho... | [
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PMID:14393 | Microbial and salivary conditions in 9- to 12-year-old children. | The prevalence of S. mutans and lactobacilli, the salivary secretion rate, and salivary pH and buffer capacity were examined in 655 children 9-12 years old. Some of these factors were correlated with the frequency of caries. Positive correlations were observed between for example S. mutans and lactobacilli, between S. ... | Microbial and salivary conditions in 9- to 12-year-old children. The prevalence of S. mutans and lactobacilli, the salivary secretion rate, and salivary pH and buffer capacity were examined in 655 children 9-12 years old. Some of these factors were correlated with the frequency of caries. Positive correlations were obs... | [
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PMID:14394 | Oral complications in anorexia nervosa. | Anorexia nervosa (AN), a psychosomatic disease mainly affecting young women, is characterized by conscious starvation, periods of excessive carbohydrate intake and often deliberate vomiting. Medical history, dental examination, and saliva tests of 39 patients aged 14 to 42 years, having suffered from AN for periods of ... | Oral complications in anorexia nervosa. Anorexia nervosa (AN), a psychosomatic disease mainly affecting young women, is characterized by conscious starvation, periods of excessive carbohydrate intake and often deliberate vomiting. Medical history, dental examination, and saliva tests of 39 patients aged 14 to 42 years,... | [
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PMID:14398 | Phenylethanolamine: a new putative neurotransmitter in Aplysia. | Phenylethanolamine is present in the Aplysia nervous system in concentrations similar to that of octopamine. These are receptors that are very specific for phenylethanolamine, which on different neurons mediate sodium, chlorine, or potassium conductance increase responses. These observations indicate that phenylethanol... | Phenylethanolamine: a new putative neurotransmitter in Aplysia. Phenylethanolamine is present in the Aplysia nervous system in concentrations similar to that of octopamine. These are receptors that are very specific for phenylethanolamine, which on different neurons mediate sodium, chlorine, or potassium conductance in... | [
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PMID:14395 | Denture stomatitis-yeast occurrence and the pH of saliva and denture plaque. | The study comprised 30 denture wearers with generalized simple or granular inflammation in the palate and 30 without (controls). )easts, mostly Candida species, were cultivated from the maxillary dentures of all subjects with inflammation and of 23 controls. Hyphae were found in the maxillary denture smears from 28 sub... | Denture stomatitis-yeast occurrence and the pH of saliva and denture plaque. The study comprised 30 denture wearers with generalized simple or granular inflammation in the palate and 30 without (controls). )easts, mostly Candida species, were cultivated from the maxillary dentures of all subjects with inflammation and ... | [
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PMID:14399 | Possible cyclic nucleotide regulation of calcium mediating myocardial contraction. | An inhibitor of adenylate and guanylate cyclases was tested on strips of left atria from rabbits. Effects of catecholamines (cardiotonic) and of acetylcholine (cardiodepressive) were blocked, and positive force-frequency was converted to negative. Ouabain produced only contracture without positive inotropy. The cardiot... | Possible cyclic nucleotide regulation of calcium mediating myocardial contraction. An inhibitor of adenylate and guanylate cyclases was tested on strips of left atria from rabbits. Effects of catecholamines (cardiotonic) and of acetylcholine (cardiodepressive) were blocked, and positive force-frequency was converted to... | [
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PMID:14400 | Glutamine synthetase: glial localization in brain. | Light microscopy immunohistochemical techniques were used to examine the distribution of glutamine synthetase in rat brain. Glutamine synthetase was found to be localized in the glial cells. Neuronal cell bodies, endothelial cells, and choroid epithelium contained no enzyme. The findings indicate that glia have a cruci... | Glutamine synthetase: glial localization in brain. Light microscopy immunohistochemical techniques were used to examine the distribution of glutamine synthetase in rat brain. Glutamine synthetase was found to be localized in the glial cells. Neuronal cell bodies, endothelial cells, and choroid epithelium contained no e... | [
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PMID:14401 | Massive skeletal trauma in renal transplant patients. | A review of 251 renal transplants done at the Vanderbilt University Medical Center since October 1962 revealed three patients who had suffered subsequent skeletal injuries sufficient to cause hospitalization. In a 37-year-old woman, a closed fracture of the pelvis healed satisfactorily in the usual period of time. In a... | Massive skeletal trauma in renal transplant patients. A review of 251 renal transplants done at the Vanderbilt University Medical Center since October 1962 revealed three patients who had suffered subsequent skeletal injuries sufficient to cause hospitalization. In a 37-year-old woman, a closed fracture of the pelvis h... | [
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PMID:14402 | Pathophysiology of propranolol in hypertension. | Only recently approved for use in the treatment of hypertension in the US, the beta-adrenergic receptor blocking compound propranolol has been used elsewhere for this purpose since 1964. The exact mechanisms to explain why and how "beta-blocking drugs" reduce arterial pressure are not known with certainty, but possible... | Pathophysiology of propranolol in hypertension. Only recently approved for use in the treatment of hypertension in the US, the beta-adrenergic receptor blocking compound propranolol has been used elsewhere for this purpose since 1964. The exact mechanisms to explain why and how "beta-blocking drugs" reduce arterial pre... | [
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PMID:14415 | Clottability and cross-linking reactivity of fibrin(ogen) following differential release of fibrinopeptides A and B. | Human fibrinogen was treated at pH 6.0, 7.3 and 9.0 with thrombin, batroxobin (thrombin-like fraction of Bothrops atrox venom) or an extract of the venom from Ancistrodon contortrix contortrix. These three enzymes released the NH2-terminal fibrinopeptides A and B at different rates. Thrombin-free, preactivated factor X... | Clottability and cross-linking reactivity of fibrin(ogen) following differential release of fibrinopeptides A and B. Human fibrinogen was treated at pH 6.0, 7.3 and 9.0 with thrombin, batroxobin (thrombin-like fraction of Bothrops atrox venom) or an extract of the venom from Ancistrodon contortrix contortrix. These thr... | [
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PMID:14416 | Soluble fibrin complexes: separation as a function of pH and characterization. | 1. The influence of the pH on the separation of high molecular weight derivatives obtained by a limited action of thrombin on fibrinogen was studied by agarose gel chromatography. When the pH of the elution buffer was 8.5, non crosslinked associations were easily separated in two peaks eluted prior to the fibrinogen pe... | Soluble fibrin complexes: separation as a function of pH and characterization. 1. The influence of the pH on the separation of high molecular weight derivatives obtained by a limited action of thrombin on fibrinogen was studied by agarose gel chromatography. When the pH of the elution buffer was 8.5, non crosslinked as... | [
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PMID:14417 | The host component of the popliteal lymph node graft-versus-host (GVH) reaction. Identification of cells in the node and kinetics of cell proliferation. | The cellular composition of rat popliteal lymph nodes undergoing a GVH reaction was examined. The great majority of cells isolated from the nodes were lymphocytes, while the contribution of phagocytic cells was negligible (less than 5%). Both T and B cells were present in GVH nodes. However, the proportion of B cells w... | The host component of the popliteal lymph node graft-versus-host (GVH) reaction. Identification of cells in the node and kinetics of cell proliferation. The cellular composition of rat popliteal lymph nodes undergoing a GVH reaction was examined. The great majority of cells isolated from the nodes were lymphocytes, whi... | [
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PMID:14419 | Effects of general anesthetics on search in memory in man. | Recovery of search functions in long-term memory following several hours of anesthesia was studied on human volunteers. Verbal as well as visual search was assessed. The anesthetics used, fluroxene and halothane, slowed down considerably the verbal search for the first few hours following anesthesia, but had very littl... | Effects of general anesthetics on search in memory in man. Recovery of search functions in long-term memory following several hours of anesthesia was studied on human volunteers. Verbal as well as visual search was assessed. The anesthetics used, fluroxene and halothane, slowed down considerably the verbal search for t... | [
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PMID:14422 | Absorption, metabolism and excretion of safrole in the rat and man. | The metabolic disposition of different doses of [14C] safrole were studied in rat and man. In both species, small amounts of orally administered safrole were absorbed rapidly and then excreted almost entirely within 24 h in the urine. In the rat, when the dose was raised from 0.6 to 750 mg/kg, a marked decrease in the ... | Absorption, metabolism and excretion of safrole in the rat and man. The metabolic disposition of different doses of [14C] safrole were studied in rat and man. In both species, small amounts of orally administered safrole were absorbed rapidly and then excreted almost entirely within 24 h in the urine. In the rat, when ... | [
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PMID:14427 | [Radiation response of mitochondria in dependence on their metabolic status (author's transl)]. | The influence of the metabolic status of mitochondria upon their radiation response was studied. It turned out that the reduction of pyridine nucleotides by addition of beta-hydroxybutyrate (BOH) and the decrease through respiration were distinctly impaired in mitochondria with a substrate deficit by an irradiation wit... | [Radiation response of mitochondria in dependence on their metabolic status (author's transl)]. The influence of the metabolic status of mitochondria upon their radiation response was studied. It turned out that the reduction of pyridine nucleotides by addition of beta-hydroxybutyrate (BOH) and the decrease through res... | [
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PMID:14428 | Chemiluminescence microanalysis of substrates and enzymes. | Extracts from bioluminescent organisms are increasingly used for analysis of small amounts of substrates and enzymes. The light emission is in some organisms related to the conversion of substrates and cofactors of central metabolic importance. Extracts from such organisms are particularly valuable for analytical appli... | Chemiluminescence microanalysis of substrates and enzymes. Extracts from bioluminescent organisms are increasingly used for analysis of small amounts of substrates and enzymes. The light emission is in some organisms related to the conversion of substrates and cofactors of central metabolic importance. Extracts from su... | [
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PMID:14431 | A contribution to the formation mechanism of calcium oxalate urinary calculi. II. In vitro experiments concerning the theory of the formation of Whewellite and Weddellite urinary calculi. | In vitro investigations of the formation of Whewellite or Weddellite are described. By means of different precipitation models the influence of cationic minerals on the formation of Weddellite could be observed. The possible conversion of Weddellite into Whewellite in vivo is demonstrated by in vitro experiments. A the... | A contribution to the formation mechanism of calcium oxalate urinary calculi. II. In vitro experiments concerning the theory of the formation of Whewellite and Weddellite urinary calculi. In vitro investigations of the formation of Whewellite or Weddellite are described. By means of different precipitation models the i... | [
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PMID:14432 | A contribution to the formation mechanism of calcium oxalate urinary calculi. III. On the role of magnesium in the formation of oxalate calculi. | The influence of magnesium in vitro on the precipitation of calcium oxalate was investigated. Even at maximum physiological magnesium concentrations a litholytic effect could not be observed, but the retardation of the calcium oxalate crystallization caused by magnesium might be decisive for a reduction in calculi form... | A contribution to the formation mechanism of calcium oxalate urinary calculi. III. On the role of magnesium in the formation of oxalate calculi. The influence of magnesium in vitro on the precipitation of calcium oxalate was investigated. Even at maximum physiological magnesium concentrations a litholytic effect could ... | [
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PMID:14447 | [Age-dependence of catecholamine effects in man. IV. Effects of specific inhibitors on the lipolytic action of alpha and beta adrenergics]. | In order to characterize age differences in the lipolytic effect of catecholamines on tests of subcutaneous adipose tissue of test persons aged from 0.1 to 10 years, from 20 to 40 years, and from 60 to 75 years the influence of propranolol, phentolamine and theophyllin on the release of glycerol by isoprenalin and adre... | [Age-dependence of catecholamine effects in man. IV. Effects of specific inhibitors on the lipolytic action of alpha and beta adrenergics]. In order to characterize age differences in the lipolytic effect of catecholamines on tests of subcutaneous adipose tissue of test persons aged from 0.1 to 10 years, from 20 to 40 ... | [
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PMID:14460 | [Stability in drinking and surface water of nine virus species from different genera (author's transl)]. | The stability of nine viruses, Aujeszky, Sindbis, Vesicular Stomatitis, Newcastle Disease, Vaccinia, FMD, HCC, Reo and Teschen virus in drinking and surface water was investigated comparatively at temperatures of 9 and 15 degrees C as well as the influence of water factors like seasonal difference in temperature, pH va... | [Stability in drinking and surface water of nine virus species from different genera (author's transl)]. The stability of nine viruses, Aujeszky, Sindbis, Vesicular Stomatitis, Newcastle Disease, Vaccinia, FMD, HCC, Reo and Teschen virus in drinking and surface water was investigated comparatively at temperatures of 9 ... | [
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PMID:14455 | [Gamma-glutamyltranspeptidase in chronic polyarthritis. I. Comparison with a control group and relationship with alkaline phosphatase]. | Gamma-GT, alcaline phosphatase and other parameters of abnormal liver functions were estimated in 54 consecutive in-patients having active RA but without a previous history or clinical signs of liver disease, and compared with a matched control group, suffering from degenerative rheumatic disease. There was a slight to... | [Gamma-glutamyltranspeptidase in chronic polyarthritis. I. Comparison with a control group and relationship with alkaline phosphatase]. Gamma-GT, alcaline phosphatase and other parameters of abnormal liver functions were estimated in 54 consecutive in-patients having active RA but without a previous history or clinical... | [
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PMID:14461 | Relationships between chemical structure and antiviral activity of some biguanide derivatives. | The aim of this report was to indicate the correlation between chemical structure and antiviral activity of some biguanide derivatives obtained according to Monsanto Chemicals Ltd. Neth. Appl. 289. 283. The studies were carried out on the culture of monkey kidney cells infected with parainfluenza Sendai virus and on th... | Relationships between chemical structure and antiviral activity of some biguanide derivatives. The aim of this report was to indicate the correlation between chemical structure and antiviral activity of some biguanide derivatives obtained according to Monsanto Chemicals Ltd. Neth. Appl. 289. 283. The studies were carri... | [
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PMID:14456 | [Gamma-glutamyltranspeptidase in chronic polyarthritis. II. Influence of drugs]. | Thirty outpatients with active RA were treated with Sudoxicam, a nonsteroidal antirheumatic drug, for periods of 6-10 months. Gamma-GT, alkaline phosphatase and transaminase were estimated at 2 week intervals. During treatment, the frequently elevated values showed a significant tendency towards normality (time trend a... | [Gamma-glutamyltranspeptidase in chronic polyarthritis. II. Influence of drugs]. Thirty outpatients with active RA were treated with Sudoxicam, a nonsteroidal antirheumatic drug, for periods of 6-10 months. Gamma-GT, alkaline phosphatase and transaminase were estimated at 2 week intervals. During treatment, the frequen... | [
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PMID:14462 | [Changes in the acid-base condition and gas composition of the blood in meningoencephalitis of meningococcal etiology]. | A study of the acid-base state in meningococcous meningoencephalitis demonstrates that there are different metabolic changes: metabolic acidosis, metabolic alkolosis, respiratory alkalosis and metabolic and respiratory alkalosis. These studies also detected a significant correlation between the character of these chang... | [Changes in the acid-base condition and gas composition of the blood in meningoencephalitis of meningococcal etiology]. A study of the acid-base state in meningococcous meningoencephalitis demonstrates that there are different metabolic changes: metabolic acidosis, metabolic alkolosis, respiratory alkalosis and metabol... | [
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PMID:14464 | [Purification and various properties of NADP+-dependent alcohol dehydrogenase from Acinetobacter calcoaceticus]. | The constitutive NADP+-dependent alcohol dehydrogenase from Acinetobacter calcoaceticus can be accumulated about 50 fold in 3 purification steps. The end-product shows in the analytical polyacrylamide gel electrophoresis only one active enzyme band. The molecular weight of the enzyme was determined to be 235,000 by gel... | [Purification and various properties of NADP+-dependent alcohol dehydrogenase from Acinetobacter calcoaceticus]. The constitutive NADP+-dependent alcohol dehydrogenase from Acinetobacter calcoaceticus can be accumulated about 50 fold in 3 purification steps. The end-product shows in the analytical polyacrylamide gel el... | [
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PMID:14465 | Synthesis, turnover and compartment analysis of the free fatty acids in the placenta of rats. | The in vivo tracer method and in vitro acetate incorporation experiments were used to investigate the metabolism of placental free fatty acids. Analysis of data revealed that free fatty acids pass into the fetus from maternal plasma through a small placental compartment, which accounts for only 5 percent of all of the ... | Synthesis, turnover and compartment analysis of the free fatty acids in the placenta of rats. The in vivo tracer method and in vitro acetate incorporation experiments were used to investigate the metabolism of placental free fatty acids. Analysis of data revealed that free fatty acids pass into the fetus from maternal ... | [
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PMID:14466 | [Antihemolytic effect of various benzodiazepines on human erythrocytes]. | The benzodiazepines, medazepam, chlorodiazepoxyde, and oxazepam, act antihemolytically just as chloropromazine in hypotonic NaCl solution on human erythrocytes. The effect depends on concentration and is biphasic with the exception of oxazepam. The maximal antihemolytic concentrations are for medazepam 9.1-10-5 M, for ... | [Antihemolytic effect of various benzodiazepines on human erythrocytes]. The benzodiazepines, medazepam, chlorodiazepoxyde, and oxazepam, act antihemolytically just as chloropromazine in hypotonic NaCl solution on human erythrocytes. The effect depends on concentration and is biphasic with the exception of oxazepam. Th... | [
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PMID:14467 | Studies on ligand binding of kidney bean leghemoglobin. | Absorption spectra of different ligand derivative;s of kidney bean leghemoglobin alpha have been recorded. The effect of pH on the absorption spectra of kidney bean leghemoglobin alpha has been studied. The pK of the acid-alkaline transition of the heme-linked water molecule is 8.25 and the pK for the acid dissociation... | Studies on ligand binding of kidney bean leghemoglobin. Absorption spectra of different ligand derivative;s of kidney bean leghemoglobin alpha have been recorded. The effect of pH on the absorption spectra of kidney bean leghemoglobin alpha has been studied. The pK of the acid-alkaline transition of the heme-linked wat... | [
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PMID:14468 | Relative value of beta blockers and thiazides for initiating antihypertensive therapy. Beta blockers or thiazides in hypertension. | Fifty-five patients with mild to moderate, renal or essential hypertension were admitted to a double blind cross-over trial of 18 weeks, involving treatment periods with placebo, the thiazide bendrofluazide (15 mg daily) and the beta blocker atenolol (600 mg daily). Compared to the placebo period (190/117 mm Hg) the hy... | Relative value of beta blockers and thiazides for initiating antihypertensive therapy. Beta blockers or thiazides in hypertension. Fifty-five patients with mild to moderate, renal or essential hypertension were admitted to a double blind cross-over trial of 18 weeks, involving treatment periods with placebo, the thiazi... | [
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PMID:14469 | Stabilization and assay of a 17beta-hydroxysteroid dehydrogenase in the serum of pregnant women. | Up to the present the activity of the 17beta-hydroxysteroid dehydrogenase (17beta-HSD) in the blood of pregnant women has not been accurately measured because of its great instability. The enzyme was stabilized by mixing fresh serum with an equal volume of potassium phosphate buffer (100 mM, PH 7.4), containing 40% (v/... | Stabilization and assay of a 17beta-hydroxysteroid dehydrogenase in the serum of pregnant women. Up to the present the activity of the 17beta-hydroxysteroid dehydrogenase (17beta-HSD) in the blood of pregnant women has not been accurately measured because of its great instability. The enzyme was stabilized by mixing fr... | [
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PMID:14470 | Glucose-6-phosphate dehydrogenase Velletri. | A new variant of red cell glucose-6-phosphate dehydrogenase (G6PD) has been found in a Caucasian man with congenital non-spherocytic haemolytic anaemia. This variant has reduced activity, increased thermolability, increased Michaelis constants for glucose-6-phosphate and NADP, slightly increased electrophoretic mobilit... | Glucose-6-phosphate dehydrogenase Velletri. A new variant of red cell glucose-6-phosphate dehydrogenase (G6PD) has been found in a Caucasian man with congenital non-spherocytic haemolytic anaemia. This variant has reduced activity, increased thermolability, increased Michaelis constants for glucose-6-phosphate and NADP... | [
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PMID:14471 | Acid-base status before and after arterial clamping. | The necessity of providing alkalizing therapy after re-establishment of the local circulation was studied in 10 otherwise healthy patients with intermittent claudication. No such necessity was found in providing stable peroperative circulation, normo- to slight hypothermia, adequate infusions, and normal acid-base valu... | Acid-base status before and after arterial clamping. The necessity of providing alkalizing therapy after re-establishment of the local circulation was studied in 10 otherwise healthy patients with intermittent claudication. No such necessity was found in providing stable peroperative circulation, normo- to slight hypot... | [
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0.... |
PMID:14472 | The pathogenesis of acute selective necrosis of the granular layer of the human cerebellar cortex. | PH determinations by means of a sturdy, spear-electrode inserted in the cerebellar tissue immediately after necropsy were carried out in 60 patients suffering from different disorders and dying in hospital, and from 25 individuals killed instantly by violent accidents. A correlation was found between the presence of NG... | The pathogenesis of acute selective necrosis of the granular layer of the human cerebellar cortex. PH determinations by means of a sturdy, spear-electrode inserted in the cerebellar tissue immediately after necropsy were carried out in 60 patients suffering from different disorders and dying in hospital, and from 25 in... | [
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PMID:14473 | Infantile periarteritis nodosa or mucocutaneous lymph node syndrome. A report on four cases and diagnostic considerations. | Coronary artery aneurysm in childhood is a rare disease and has in most cases been ascribed to infantile periarteritis nodosa (IPN). In recent years a mucocutaneous lymph node syndrom (MLNS) has been found almost exclusively in Japan first described by Kawasaki 1967; this disease frequently involves the coronary arteri... | Infantile periarteritis nodosa or mucocutaneous lymph node syndrome. A report on four cases and diagnostic considerations. Coronary artery aneurysm in childhood is a rare disease and has in most cases been ascribed to infantile periarteritis nodosa (IPN). In recent years a mucocutaneous lymph node syndrom (MLNS) has be... | [
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PMID:14474 | Human interferon and cell growth inhibition. II. Biological and physico-chemical properties of the growth inhibitory component. | Human leukocyte interferon (IF) inhibits the growth rate of homologous cells in culture. The growth inhibitory component, formerly separated from the antiviral component of human leukocyte IF by adsorption chromatography on albumin-agarose, is investigated. The properties of the component are compared with the accepted... | Human interferon and cell growth inhibition. II. Biological and physico-chemical properties of the growth inhibitory component. Human leukocyte interferon (IF) inhibits the growth rate of homologous cells in culture. The growth inhibitory component, formerly separated from the antiviral component of human leukocyte IF ... | [
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PMID:14475 | C1 subcomponents in acute pneumococcal otitis media in children. | Twenty children with acute pneumococcal otitis media were studied. In 6 children the infection ran a normal course and healed after the first episode and in 14 it relapsed. The serum levels of the immunoglobulins IgG, IgA and IgM were normal in all 20 children. Specific antibodies to pneumococcal polysaccharide were fo... | C1 subcomponents in acute pneumococcal otitis media in children. Twenty children with acute pneumococcal otitis media were studied. In 6 children the infection ran a normal course and healed after the first episode and in 14 it relapsed. The serum levels of the immunoglobulins IgG, IgA and IgM were normal in all 20 chi... | [
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PMID:14477 | Digestive enzymes of three teleost fishes. | The activity of amylase, sucrase, protease and lipase has been examined in Wallago attu, Clarias batrachus and Labeo rohita. The optimum pH value for carbohydrases ranges from 5.0 to 7.0 and that for trypsin between pH 6.8 and 7.8. Lipase is active at a slightly more alkaline medium. The optimum pH for a given enzyme v... | Digestive enzymes of three teleost fishes. The activity of amylase, sucrase, protease and lipase has been examined in Wallago attu, Clarias batrachus and Labeo rohita. The optimum pH value for carbohydrases ranges from 5.0 to 7.0 and that for trypsin between pH 6.8 and 7.8. Lipase is active at a slightly more alkaline ... | [
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0.01017560064792633,
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0.036624... |
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