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PMID:14767 | The effect of a single dose of reserpine administered prior to incubation on the development of tyrosine hydroxylase activity in chick sympathetic ganglia. | A single dose of reserpine administered into the yolk sac of chicken eggs prior to incubation produces two distinct periods of significant increase in tyrosine hydroxylase (TH) activity over controls. The first period is 21 days of incubation (55%) and the second is between day 14 and 30 after hatching (a.h.) (69%). Ch... | The effect of a single dose of reserpine administered prior to incubation on the development of tyrosine hydroxylase activity in chick sympathetic ganglia. A single dose of reserpine administered into the yolk sac of chicken eggs prior to incubation produces two distinct periods of significant increase in tyrosine hydr... | [
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PMID:14768 | Responsiveness of neurones in the hippocampal region of anaesthetised and unanaesthetised cats to stimulation of sensory pathways. | The responses to sensory stimuli and to shocks to the optic pathways have been studied for 399 units in the hippocampal region of 19 cats. 172 units were recorded from anaesthetised cats and 229 from 7 unanaesthetised cats. In the unanaesthetised animals the proportions of units responding were high (60%) and did not d... | Responsiveness of neurones in the hippocampal region of anaesthetised and unanaesthetised cats to stimulation of sensory pathways. The responses to sensory stimuli and to shocks to the optic pathways have been studied for 399 units in the hippocampal region of 19 cats. 172 units were recorded from anaesthetised cats an... | [
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PMID:14769 | Target organ regulation of sympathetic neuron development. | The role of target organs in the morphological and biochemical development of sympathetic neurons was examined in the neonatal rat. The superior cervical ganglion (SCG) and its end organs, the salivary glands and iris were employed as a model system. Unilateral sialectomy and iridectomy prevented the normal development... | Target organ regulation of sympathetic neuron development. The role of target organs in the morphological and biochemical development of sympathetic neurons was examined in the neonatal rat. The superior cervical ganglion (SCG) and its end organs, the salivary glands and iris were employed as a model system. Unilateral... | [
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PMID:14771 | A comparative study of alkaline phosphatase in calcifying cartilage, odontoblasts and the enamel organ. | The enzyme alkaline phosphatase (AP) (EC 3.1.3.1) in three different calcification areas was studied by means of a spectrophotometric micro method using p-nitrophenylphosphate as a substrate. Rat maxillary incisor odontoblasts and enamel organ from the zones of matrix formation and maturation and tissue from rabbit met... | A comparative study of alkaline phosphatase in calcifying cartilage, odontoblasts and the enamel organ. The enzyme alkaline phosphatase (AP) (EC 3.1.3.1) in three different calcification areas was studied by means of a spectrophotometric micro method using p-nitrophenylphosphate as a substrate. Rat maxillary incisor od... | [
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PMID:14772 | Buprenorphine hydrochloride: determination of analgesic potency. | An open evaluation of relief from severe pain following major abdominal operations was carried out on at least ten patients, who had given written consent, with 0.1 to 0.4 mg doses of buprenorphine hydrochloride administered intramuscularly. Statistical analysis of the data showed that 0.3 mg of this compound provided ... | Buprenorphine hydrochloride: determination of analgesic potency. An open evaluation of relief from severe pain following major abdominal operations was carried out on at least ten patients, who had given written consent, with 0.1 to 0.4 mg doses of buprenorphine hydrochloride administered intramuscularly. Statistical a... | [
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PMID:14773 | Rapid intubation with fazadinium and suxamethonium. | Fazadinium at two dose levels (1 mg/kg and 1.5 mg/kg) and suxamethonium at three dose levels (50 mg, 75 mg and 100 mg) were investigated in 106 adult patients to determine the time interval from injection to tracheal intubation. The intubating conditions were graded according to the scheme described by Lund and Stovner... | Rapid intubation with fazadinium and suxamethonium. Fazadinium at two dose levels (1 mg/kg and 1.5 mg/kg) and suxamethonium at three dose levels (50 mg, 75 mg and 100 mg) were investigated in 106 adult patients to determine the time interval from injection to tracheal intubation. The intubating conditions were graded a... | [
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PMID:14774 | Characterization of the interaction between chymotrypsin and heparin. | Heparin forms a complex with chymotrypsin which is active towards glutaryl-L-phenylalanine-p-nitroanilide (GPANA) and glutaryl-L-phenylalanine-beta-naphthylamide (GPNA) at pH 7.6. The activity of chymotrypsin towards GPANA at pH 7.6 is enhanced in the presence of heparin. Heparin does not bind at the active site of the... | Characterization of the interaction between chymotrypsin and heparin. Heparin forms a complex with chymotrypsin which is active towards glutaryl-L-phenylalanine-p-nitroanilide (GPANA) and glutaryl-L-phenylalanine-beta-naphthylamide (GPNA) at pH 7.6. The activity of chymotrypsin towards GPANA at pH 7.6 is enhanced in th... | [
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PMID:14775 | Isolation and properties of a ferredoxin from leaves of Sambucus racemosa L. | Ferredoxin was isolated in good yield from leaves of Sambucus racemosa L. by the following procedure: (1) homogenization in buffered acetone-water (1:1v/v); (2) ion-exchange chromatography on several columns of DEAE-cellulose; and (3) purification by gel filtration with Sephadex G-75. The ultraviolet and visible spectr... | Isolation and properties of a ferredoxin from leaves of Sambucus racemosa L. Ferredoxin was isolated in good yield from leaves of Sambucus racemosa L. by the following procedure: (1) homogenization in buffered acetone-water (1:1v/v); (2) ion-exchange chromatography on several columns of DEAE-cellulose; and (3) purifica... | [
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PMID:14776 | NADPH-dependent lipid peroxidation and its effects on aminopyrine N-demethylation in subcellular fractions of human neonatal liver. | NADPH-dependent lipid peroxidation was determined in humans, using subcellular fractions of livers obtained from newborn infants. As reported for other species, activity was concentrated in the microsomal fraction and was similar to that found in the rat. High activity of lipid peroxidation induced by iron decreased am... | NADPH-dependent lipid peroxidation and its effects on aminopyrine N-demethylation in subcellular fractions of human neonatal liver. NADPH-dependent lipid peroxidation was determined in humans, using subcellular fractions of livers obtained from newborn infants. As reported for other species, activity was concentrated i... | [
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PMID:14777 | Flow rates of components in digesta of pigs prepared with re-entrant cannulas in the proximal duodenum and terminal ileum, and fed semipurified, hard wheat, and soft wheat diets. | Four pigs prepared with re-entrant cannulas in the proximal duodenum and terminal ileum were used to study flow rates of total digesta, insoluble dry matter, nitrogen, and amino acids entering and leaving the small intestine. The pigs received a semipurified diet, a hard wheat diet, or a soft wheat diet. These were app... | Flow rates of components in digesta of pigs prepared with re-entrant cannulas in the proximal duodenum and terminal ileum, and fed semipurified, hard wheat, and soft wheat diets. Four pigs prepared with re-entrant cannulas in the proximal duodenum and terminal ileum were used to study flow rates of total digesta, insol... | [
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PMID:14778 | Evoked release from guinea pig cerebral cortex slices of endogenous 14C-labelled amino acids, labelled via D-[U-14C]glucose. | Release of endogenous amino acids labelled via D-[U-14C]glucose was compared with that of several exogenous labelled amino acids using slices of guinea pig cerebral cortex. Electrical field stimulation evoked a selective release of endogenous [14C]glutamate, [14C]aspartate, and gamma-amino[14C]butyrate (14C-labelled GA... | Evoked release from guinea pig cerebral cortex slices of endogenous 14C-labelled amino acids, labelled via D-[U-14C]glucose. Release of endogenous amino acids labelled via D-[U-14C]glucose was compared with that of several exogenous labelled amino acids using slices of guinea pig cerebral cortex. Electrical field stimu... | [
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PMID:14779 | Ca2+-dependence of the evoked release from guinea pig cerebral cortex slices of endogenous 14C-labelled amino acids, labelled via D-[U-14C]glucose. | Spontaneous and electrically evoked release of exogenous labelled amino acids and endogenous amino acids labelled from D-[U-14C]glucose were compared in control and Ca2+-free medium using guinea pig cerebral cortex slices. Spontaneous release of all labelled amino acids, except that of endogenous 14C-labelled threonine... | Ca2+-dependence of the evoked release from guinea pig cerebral cortex slices of endogenous 14C-labelled amino acids, labelled via D-[U-14C]glucose. Spontaneous and electrically evoked release of exogenous labelled amino acids and endogenous amino acids labelled from D-[U-14C]glucose were compared in control and Ca2+-fr... | [
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PMID:14780 | Effects of saline infusion and acute metabolic acidosis and alkalosis on water and electrolyte transport in the human colon. | Both the kidney and colon secrete bicarbonate and transport water and electrolytes. The respective contributions of these two organs to acid-base and electrolyte balance in normal man has thus been studied in eight healthy male volunteers who underwent simultaneous renal clearance studies, and colonic perfusion with a ... | Effects of saline infusion and acute metabolic acidosis and alkalosis on water and electrolyte transport in the human colon. Both the kidney and colon secrete bicarbonate and transport water and electrolytes. The respective contributions of these two organs to acid-base and electrolyte balance in normal man has thus be... | [
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PMID:14781 | Induction of urogenital anomalies and some tumors in the progeny of mice receiving diethylstilbestrol during pregnancy. | Pregnant mice were given a single dose (10 mug/g body weight) of diethylstilbestrol (DES) on Days 7 to 19, which correspond to the first to fifth lunar months in humans, after the authors, using a 14C-labeled compound, confirmed easy placental penetration by DES. Treatment with DES on Days 15 to 19 resulted in the indu... | Induction of urogenital anomalies and some tumors in the progeny of mice receiving diethylstilbestrol during pregnancy. Pregnant mice were given a single dose (10 mug/g body weight) of diethylstilbestrol (DES) on Days 7 to 19, which correspond to the first to fifth lunar months in humans, after the authors, using a 14C... | [
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PMID:14782 | Production of formaldehyde from N5-methyltetrahydrofolate by normal and leukemic leukocytes. | Extracts of human normal and leukemic leukocytes contain an enzyme that catalyzes a transfer of labeled methyl carbon from N5-[14C]methyltetrahydrofolate to tryptamine. Evidence is presented that this reaction is not attributable to a methyltransferase but to the following reaction sequence: (a) an oxidation of N5-[14C... | Production of formaldehyde from N5-methyltetrahydrofolate by normal and leukemic leukocytes. Extracts of human normal and leukemic leukocytes contain an enzyme that catalyzes a transfer of labeled methyl carbon from N5-[14C]methyltetrahydrofolate to tryptamine. Evidence is presented that this reaction is not attributab... | [
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PMID:14783 | Suppression of antibody-mediated and cell-mediated murine immunity by the carcinogen N-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide. | N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide (NFTA) administered at 1000 ppm in diet to mice for 12 weeks induced a high incidence of lymphocytic leukemia. Effects of NFTA on antibody-mediated immunity and cell-mediated immunity of BALB/c mice were studied using the spleen plaque assay for detection of immunoglobulin M... | Suppression of antibody-mediated and cell-mediated murine immunity by the carcinogen N-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide. N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide (NFTA) administered at 1000 ppm in diet to mice for 12 weeks induced a high incidence of lymphocytic leukemia. Effects of NFTA on antibody-media... | [
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PMID:14784 | Inhibitors of L-asparagine synthetase, in vitro. | A systematic search has been made for inhibitors of L-asparagine synthetase (L-glutamine hydrolyzing, EC 6.3.5.4) from leukemia 5178Y/AR, a rodent neoplasm resistant to the oncolytic enzyme L-asparaginase (EC 3.5.1.1), The classes of chemicals examined in this search included substrate and product analogs, agents capab... | Inhibitors of L-asparagine synthetase, in vitro. A systematic search has been made for inhibitors of L-asparagine synthetase (L-glutamine hydrolyzing, EC 6.3.5.4) from leukemia 5178Y/AR, a rodent neoplasm resistant to the oncolytic enzyme L-asparaginase (EC 3.5.1.1), The classes of chemicals examined in this search inc... | [
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PMID:14785 | Coprecipitation of active uridine kinase and phosphomonoesterase from rat kidney by Zn2+-ions. III. Enzymes relevant to cancer chemotherapy. | Partially purified enzyme fraction from rat kidney possessing high uridine kinase and phosphomonoesterase activity was insolubilized by means of zinc precipitation without substantial loss of the activity. While uridine kinase in a soluble and Zn-precipitated form was inhibited by low concentrations (0.5-1.0 mM) of Zn2... | Coprecipitation of active uridine kinase and phosphomonoesterase from rat kidney by Zn2+-ions. III. Enzymes relevant to cancer chemotherapy. Partially purified enzyme fraction from rat kidney possessing high uridine kinase and phosphomonoesterase activity was insolubilized by means of zinc precipitation without substan... | [
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PMID:14790 | Effects of adrenergic amines on electrophysiological properties and automaticity of neonatal and adult canine Purkinje fibers: evidence for alpha- and beta-adrenergic actions. | We determined age-related differences in automaticity and responsiveness of cardiac Purkinje fibers from adult and neonatal dogs to graded concentrations of epinephrine, isoproterenol, and phenylephrine. Purkinje fibers were studied with standard microelectrode techniques during superfusion with Tyrode's solution at 37... | Effects of adrenergic amines on electrophysiological properties and automaticity of neonatal and adult canine Purkinje fibers: evidence for alpha- and beta-adrenergic actions. We determined age-related differences in automaticity and responsiveness of cardiac Purkinje fibers from adult and neonatal dogs to graded conce... | [
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PMID:14791 | Autonomic control of cardiovascular functions during neonatal development and in adult sheep. | We studied the autonomic control of resting heart rate of systemic and pulmonary vascular blood pressures (BP) in chronically instrumented neonatal lambs 1-8 weeks of age. The maximum response to ganglionic blockade and sympathetic and parasympathetic antagonists was taken as an index of the magnitude of the total neur... | Autonomic control of cardiovascular functions during neonatal development and in adult sheep. We studied the autonomic control of resting heart rate of systemic and pulmonary vascular blood pressures (BP) in chronically instrumented neonatal lambs 1-8 weeks of age. The maximum response to ganglionic blockade and sympat... | [
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PMID:14792 | Baroreflex sensitivity in patients with Takayasu's aortitis. | Takayasu's aortitis is an arterial inflammatory disease of arteries of unknown etiology. Fainting is a common symptom and has been attributed to ypersensitivity of the baroreflex. We studied baroreflex sensitivity in 11 patients with Takayasu's aortitis and compared it with that of eight control subjects of comparable ... | Baroreflex sensitivity in patients with Takayasu's aortitis. Takayasu's aortitis is an arterial inflammatory disease of arteries of unknown etiology. Fainting is a common symptom and has been attributed to ypersensitivity of the baroreflex. We studied baroreflex sensitivity in 11 patients with Takayasu's aortitis and c... | [
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PMID:14793 | Amperometric determination of total cholesterol in serum, with use of immobilized cholesterol ester hydrolase and cholesterol oxidase. | We describe an electrochemical method for simple, rapid, and economical assay of total serum cholesterol with use of immobilized cholesterol esterase (EC 3.1.1.13) and cholesterol oxidase (EC 1.1.3.6). A rotating porous cell was specially designed to hold the immobilized enzymes firmly and to allow the reaction mixture... | Amperometric determination of total cholesterol in serum, with use of immobilized cholesterol ester hydrolase and cholesterol oxidase. We describe an electrochemical method for simple, rapid, and economical assay of total serum cholesterol with use of immobilized cholesterol esterase (EC 3.1.1.13) and cholesterol oxida... | [
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PMID:14794 | Evaluation of a new automatic calcium ion analyzer. | We evaluated a new automatic analyzer for ionized calcium (Ca2+), the Orion Model SS-20, based on a flowthrough ion-exchange electrode. Ca2+ was measured in heparinized whole blood and serum. Within-day variation was 1.2%, day-to-day variation1.6%, and analytical recovery 92.4%. Over the phsiological range interference... | Evaluation of a new automatic calcium ion analyzer. We evaluated a new automatic analyzer for ionized calcium (Ca2+), the Orion Model SS-20, based on a flowthrough ion-exchange electrode. Ca2+ was measured in heparinized whole blood and serum. Within-day variation was 1.2%, day-to-day variation1.6%, and analytical reco... | [
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PMID:14796 | The diagnosis of Gaucher's disease in liver using 4-methylumbelliferyl-beta-D-glucopyranoside. | 1. Cases of Gaucher's disease could not be distinguished from controls by the assay of beta-glucosidase activity in water homogenates of liver using 4-methylumbelliferyl-beta-D glucopyranoside. 2. Two peaks of beta-glucosidase activity were separated by Sephadex G-150 gel filtration in control and Gaucher livers. In th... | The diagnosis of Gaucher's disease in liver using 4-methylumbelliferyl-beta-D-glucopyranoside. 1. Cases of Gaucher's disease could not be distinguished from controls by the assay of beta-glucosidase activity in water homogenates of liver using 4-methylumbelliferyl-beta-D glucopyranoside. 2. Two peaks of beta-glucosidas... | [
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PMID:14797 | A new semiautomated fluorometric method for estimation of small amounts of L-dopa in human urine. | A semiautomated fluorometric method for the quantitative determination of urinary dopa, 3-(3,4-dihydroxyphenyl)-L-alanine, is described. It provides a simple, sensitive and reproducible analytical technique for routine use. Dopa is isolated from interfering substances, especially catecholamines, by adsorption onto alum... | A new semiautomated fluorometric method for estimation of small amounts of L-dopa in human urine. A semiautomated fluorometric method for the quantitative determination of urinary dopa, 3-(3,4-dihydroxyphenyl)-L-alanine, is described. It provides a simple, sensitive and reproducible analytical technique for routine use... | [
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PMID:14798 | Phenylethanolamine N-methyltransferase and other enzymes of catecholamine metabolism in human brain. | The activities of tyrosine hydroxylase (TH), DOPA decarboxylase (DDC), dopamine beta-hydroxylase (DBH), phenylethanolamine N-methyltransferase (PNMT), and monoamine oxidase (MAO) with serotonin and phenylethylamine as substrates were measured in catecholaminergic regions of human brain from 10 controls and 3 patients w... | Phenylethanolamine N-methyltransferase and other enzymes of catecholamine metabolism in human brain. The activities of tyrosine hydroxylase (TH), DOPA decarboxylase (DDC), dopamine beta-hydroxylase (DBH), phenylethanolamine N-methyltransferase (PNMT), and monoamine oxidase (MAO) with serotonin and phenylethylamine as s... | [
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PMID:14799 | Influence of the pH on the antigen-antibody coupling in angiotensin I radioimmunoassay. Its consequences for the determination of the plasma renin activity. | The antigen-antibody complex formation in the angiotensin I radioimmunoassay appears to be influenced by the pH of the radioimmunoassay incubation mixture. This may lead to erroneous results in the determination of the plasma renin activity, when an aliquot of a plasma sample, buffered at pH 6 for optimum renin activit... | Influence of the pH on the antigen-antibody coupling in angiotensin I radioimmunoassay. Its consequences for the determination of the plasma renin activity. The antigen-antibody complex formation in the angiotensin I radioimmunoassay appears to be influenced by the pH of the radioimmunoassay incubation mixture. This ma... | [
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PMID:14802 | Acute overdosage with benzodiazepine derivatives. | A total of 773 admissions to Massachusetts General Hospital between 1962 and 1975 were due to acute overdosage with one or more psychotropic drugs. Benzodiazepine overdosage, particularly with diazepam, increased relative to other psychotropic drugs over the years. Only 12 admissions were due to benzodiazepine overdosa... | Acute overdosage with benzodiazepine derivatives. A total of 773 admissions to Massachusetts General Hospital between 1962 and 1975 were due to acute overdosage with one or more psychotropic drugs. Benzodiazepine overdosage, particularly with diazepam, increased relative to other psychotropic drugs over the years. Only... | [
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PMID:14803 | Effects of metabolic alkalosis, metabolic acidosis and uraemia on whole-body intracellular pH in man. | 1. Whole-body intracellular pH (pHi) was measured by the 14C-labelled DMO method in twenty-four control subjects, eighteen normal subjects with induced acute metabolic alkalosis, ten normal subjects with induced acute metabolic acidosis, twelve normal subjects with chronic acidosis and in fifteen patients with chronic ... | Effects of metabolic alkalosis, metabolic acidosis and uraemia on whole-body intracellular pH in man. 1. Whole-body intracellular pH (pHi) was measured by the 14C-labelled DMO method in twenty-four control subjects, eighteen normal subjects with induced acute metabolic alkalosis, ten normal subjects with induced acute ... | [
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PMID:14804 | Enzyme activities in human liver biopsies: assay methods and activities of some lysosomal and membrane-bound enzymes in control tissue and serum. | 1. Highly sensitive technique are described for the assay of plasma membrane (5'-nucleotidase, alkaline phosphatase), microsomal (neutral alpha-glucosidase, leucyl-2-naphthylamidase) and biliary canalicular (gamma-glutamyltransferase) enzymes and for nine acid hydrolases (acid phosphatase, phosphodiesterase, beta-gluco... | Enzyme activities in human liver biopsies: assay methods and activities of some lysosomal and membrane-bound enzymes in control tissue and serum. 1. Highly sensitive technique are described for the assay of plasma membrane (5'-nucleotidase, alkaline phosphatase), microsomal (neutral alpha-glucosidase, leucyl-2-naphthyl... | [
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PMID:14805 | Lysosomal changes in liver tissue from patients with the Dubin-Johnson-Sprinz syndrome. | 1. Clinical, morphological and biochemical data, including data obtained from the application of subcellular fractionation techniques to liver biopsy specimens, are presented for two patients with the Dubin-Johnson-Sprinz (DJS) syndrome. 2. Subcellular fractionation experiments demonstrate that the lysosomes, which hav... | Lysosomal changes in liver tissue from patients with the Dubin-Johnson-Sprinz syndrome. 1. Clinical, morphological and biochemical data, including data obtained from the application of subcellular fractionation techniques to liver biopsy specimens, are presented for two patients with the Dubin-Johnson-Sprinz (DJS) synd... | [
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PMID:14806 | Leucocyte intracellular pH in patients with the metabolic acidosis of renal failure. | 1. Human leucocytes were isolated from venous blood and resuspended in the subjects plasma. 2. Intracellular pH measurements were made in vitro by the dimethyloxazolidinedione technique in 13 healthy subjects and in 11 subjects with renal failure and metabolic acidosis. 3. The intracellular pH of the healthy subjects w... | Leucocyte intracellular pH in patients with the metabolic acidosis of renal failure. 1. Human leucocytes were isolated from venous blood and resuspended in the subjects plasma. 2. Intracellular pH measurements were made in vitro by the dimethyloxazolidinedione technique in 13 healthy subjects and in 11 subjects with re... | [
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PMID:14808 | The influence of instructional set on schizophrenic vs. organic concreteness. | 36 male patients (12 schizophrenic, 12 organic, and 12 neurotic), age 19-57, each took two forms of the Gorham Proverbs test under two different instructional sets. It was hypothesized that for schizophrenics, a higher level of abstraction would be obtained on the proverbs task when the instructions required less perso... | The influence of instructional set on schizophrenic vs. organic concreteness. 36 male patients (12 schizophrenic, 12 organic, and 12 neurotic), age 19-57, each took two forms of the Gorham Proverbs test under two different instructional sets. It was hypothesized that for schizophrenics, a higher level of abstraction wo... | [
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PMID:14812 | Pulmonary artery involvement in Takayasu's arteritis. | Although pulmonary artery disease in Takayasu's arteritis has been described since 1940, it has received little attention. The clinical, hemodynamic, and angiographic features of the pulmonary involvement were studied in 22 patients with systemic arterial disease. Pulmonary involvement was found in 50 percent of the ca... | Pulmonary artery involvement in Takayasu's arteritis. Although pulmonary artery disease in Takayasu's arteritis has been described since 1940, it has received little attention. The clinical, hemodynamic, and angiographic features of the pulmonary involvement were studied in 22 patients with systemic arterial disease. P... | [
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PMID:14813 | Three types of paranoid processes. | In classical descriptive psychiatry the term 'paranoid' is often used ambiguously -- referring to a variety of clinical processes which should be more clearly differentiated. Specifically, in this paper, we have differentiated three distinct sets of clinical phenomena all usually lumped together as 'paranoid': 1. Paran... | Three types of paranoid processes. In classical descriptive psychiatry the term 'paranoid' is often used ambiguously -- referring to a variety of clinical processes which should be more clearly differentiated. Specifically, in this paper, we have differentiated three distinct sets of clinical phenomena all usually lump... | [
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PMID:14809 | Application of the Starling resistor concept to the lungs during CPPV. | The application of the Starling resistor concept of the lungs during continuous positive pressure ventilation (CPPV) was evaluated. Ventilation and hemodynamics were studied in eight anesthetized and paralyzed dogs before and during the use of CPPV. CPPV resulted in an increase in transpulmonary pressure and functional... | Application of the Starling resistor concept to the lungs during CPPV. The application of the Starling resistor concept of the lungs during continuous positive pressure ventilation (CPPV) was evaluated. Ventilation and hemodynamics were studied in eight anesthetized and paralyzed dogs before and during the use of CPPV.... | [
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PMID:14816 | [Sympathetic responsiveness and antihypertensive effect of beta-receptor blockade in essential hypertension: the effect of atenolol (author's transl)]. | Plasmin noradrenaline concentration after bicycle exercise (200 W for 2 min), compared with base line concentration, was used as an index of sympathetic responsiveness in patients with essential hypertension. Atenolol (JCI 66082, a "cardioselective" beta-blocker) was given in a daily dose of 200 mg to 16 patients for f... | [Sympathetic responsiveness and antihypertensive effect of beta-receptor blockade in essential hypertension: the effect of atenolol (author's transl)]. Plasmin noradrenaline concentration after bicycle exercise (200 W for 2 min), compared with base line concentration, was used as an index of sympathetic responsiveness ... | [
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PMID:14818 | [Effect of beta-adrenergic blockers on complement]. | The authors, examined the effect of beta-adrenergic blockers Propranolol, Pindolol, Practonol and P11 on complement in the serum of guinea pigs after continuous administration. The follow-up was made dynamicaly: on the 10th, 20th and 30th day. There was a considerable lowering of the complement level on the 20th and 30... | [Effect of beta-adrenergic blockers on complement]. The authors, examined the effect of beta-adrenergic blockers Propranolol, Pindolol, Practonol and P11 on complement in the serum of guinea pigs after continuous administration. The follow-up was made dynamicaly: on the 10th, 20th and 30th day. There was a considerable... | [
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PMID:14819 | [Participation of the adrenals in the pathogenesis of metabolic acid-base disorders]. | The authors examined in dynamics the changes in the functional state of the adrenals on 240 rabbits, which served as models for acute metabolic deviations in the acid-base balance. The obtained results showed that the acute metabolic acidosis increased moderately the values of ACTH and 17-hydroxycorticosteroids in bloo... | [Participation of the adrenals in the pathogenesis of metabolic acid-base disorders]. The authors examined in dynamics the changes in the functional state of the adrenals on 240 rabbits, which served as models for acute metabolic deviations in the acid-base balance. The obtained results showed that the acute metabolic ... | [
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PMID:14820 | [Comparative study of the effect of haloperidol and maptil on the karyotype and immunoproliferative response of lymphocytes]. | The author examined the action of haloperidol and magetyl on the mitotic activity, blast transformation and karyotype of the lymphocytic cultures, obtained from the peripheral blood in vitro. The experiments were carried out on flymphycytes, obtained from ten healthy individuals. Nontreated cultures, obtained from the ... | [Comparative study of the effect of haloperidol and maptil on the karyotype and immunoproliferative response of lymphocytes]. The author examined the action of haloperidol and magetyl on the mitotic activity, blast transformation and karyotype of the lymphocytic cultures, obtained from the peripheral blood in vitro. Th... | [
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PMID:14821 | Uptake of NADPH by islet secretion granule membranes. | Reduced nicotinamide adenine dinucleotide phosphate (NADPH), which stimulated the release of insulin from toadfish islet cells and from isolated secretion granules, was taken up by the membranes prepare from these secretion granules. Oxidized nicotinamide adenine dinucleotide phosphate, which did not release insulin fr... | Uptake of NADPH by islet secretion granule membranes. Reduced nicotinamide adenine dinucleotide phosphate (NADPH), which stimulated the release of insulin from toadfish islet cells and from isolated secretion granules, was taken up by the membranes prepare from these secretion granules. Oxidized nicotinamide adenine di... | [
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PMID:14822 | Failure of neurotransmitter blockers to alter PGE2-induced LH release. | The purpose of this study is to ascertain whether or not prostaglandin (PG) E2 induces LH release by modifying or mudulating the release or action of neural transmitters. PGE2 injected inv into spayed rats primed two days earlier with 10 mug estradiol benzoate increased the plasma levels of LH 10 min later as measured ... | Failure of neurotransmitter blockers to alter PGE2-induced LH release. The purpose of this study is to ascertain whether or not prostaglandin (PG) E2 induces LH release by modifying or mudulating the release or action of neural transmitters. PGE2 injected inv into spayed rats primed two days earlier with 10 mug estradi... | [
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PMID:14825 | Purification of an endonuclease from adenovirus-infected KB cells. | This report describes the purification of an endonuclease from extracts of adenovirus-type-2-infected KB cells. Endonuclease activity can also be detected in extracts of uninfected KB cells and the enzyme activities from extracts of uninfected and adenovirus-infected cells are very similar, if not identical. The enzyme... | Purification of an endonuclease from adenovirus-infected KB cells. This report describes the purification of an endonuclease from extracts of adenovirus-type-2-infected KB cells. Endonuclease activity can also be detected in extracts of uninfected KB cells and the enzyme activities from extracts of uninfected and adeno... | [
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PMID:14826 | Characterization of the pH 4.0 endonuclease from adenovirus-type-2-infected KB cells. | The properties of the pH 4.0 endonuclease from adenovirus-type-2-infected KB cells were determined. The enzyme has a molecular weight of approximately 40000. Its pH optimum is at pH 4.0, it is not inhibited by ethylenediaminetetraacetate (EDTA), and it is active at temperatures up to 60 degree C. The enzyme cleaves ade... | Characterization of the pH 4.0 endonuclease from adenovirus-type-2-infected KB cells. The properties of the pH 4.0 endonuclease from adenovirus-type-2-infected KB cells were determined. The enzyme has a molecular weight of approximately 40000. Its pH optimum is at pH 4.0, it is not inhibited by ethylenediaminetetraacet... | [
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PMID:14827 | Affinity labeling of rat-kidney gamma-glutamyl transpeptidase. | The reaction of gamma-glutamyl transpeptidase from rat kidney with a glutamine analog, 6-diazo-5-oxo-L-norleucine, resulted in irreversible inactivation of the enzyme. The concentration of this reagent giving a half-maximum rate of inactivation was 6 mMat pH 7.5. The inactivation was prevented by the presence of reduce... | Affinity labeling of rat-kidney gamma-glutamyl transpeptidase. The reaction of gamma-glutamyl transpeptidase from rat kidney with a glutamine analog, 6-diazo-5-oxo-L-norleucine, resulted in irreversible inactivation of the enzyme. The concentration of this reagent giving a half-maximum rate of inactivation was 6 mMat p... | [
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PMID:14828 | Superoxide dismutase from Thermus aquaticus. Isolation and characterisation of manganese and apo enzymes. | Superoxide dismutase has been isolated and characterised from the extreme thermophile Thermus aquaticus. The pure enzyme is a reddish-purple manganese-containing protein with a molecular weight of approximately 80000 +/- 5000. Combination of gel electrophoresis in dodecylsulphate and amino acid analysis shows that it i... | Superoxide dismutase from Thermus aquaticus. Isolation and characterisation of manganese and apo enzymes. Superoxide dismutase has been isolated and characterised from the extreme thermophile Thermus aquaticus. The pure enzyme is a reddish-purple manganese-containing protein with a molecular weight of approximately 800... | [
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PMID:14829 | PH-dependent changes of 2,3-bisphosphoglycerate in human red cells during transitional and steady states in vitro. | A systematic study of the pH-dependent changes in the range 6.6--7.4 of 2,3-bisphosphoglycerate and the adenine nucleotides was performed in the presence and absence of glucose during transitional and steady states. 1. The results indicatethat 2,3-gisphosphoglycerate phosphatase breaks down 2,3-bisphosphoglycerate near... | PH-dependent changes of 2,3-bisphosphoglycerate in human red cells during transitional and steady states in vitro. A systematic study of the pH-dependent changes in the range 6.6--7.4 of 2,3-bisphosphoglycerate and the adenine nucleotides was performed in the presence and absence of glucose during transitional and stea... | [
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PMID:14830 | Carboxyl groups at the two active centers of sucrase-isomaltase from rabbit small intestine. | 1. Seveal selective reagents were employed to identify the amino acid residues essential for the catalytic activity of sucrase-isomaltase. 2. Modification of histidine, lysine and carboxyl residues resulted in a partial inactivation of the enzyme. Substrates or competitive inhibitors provided protection against inactiv... | Carboxyl groups at the two active centers of sucrase-isomaltase from rabbit small intestine. 1. Seveal selective reagents were employed to identify the amino acid residues essential for the catalytic activity of sucrase-isomaltase. 2. Modification of histidine, lysine and carboxyl residues resulted in a partial inactiv... | [
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PMID:14831 | A mutant ATP synthetase of Escherichia coli with an altered sensitivity to N,N' -dicyclohexylcarbodiimide: characterization in native membranes and reconstituted proteoliposomes. | Dicyclohexylcarbodiimide-resistant mutants of Escherichia coli were isolated and characterized In one mutant the unc genes and affects the membrane-integrated part of the ATP synthetase. The sensitivity of ATP synthetase functions to N,N' -dicyclohexylcarbodiimide was compared in wild-type and mutant membranes. The mem... | A mutant ATP synthetase of Escherichia coli with an altered sensitivity to N,N' -dicyclohexylcarbodiimide: characterization in native membranes and reconstituted proteoliposomes. Dicyclohexylcarbodiimide-resistant mutants of Escherichia coli were isolated and characterized In one mutant the unc genes and affects the me... | [
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PMID:14832 | Proton movements coupled to sugar transport via the galactose transport system in Salmonella typhimurium. | We have studied proton movements associated with substrate transport via the galactose transport system in Salmonella typhimurium. The addition of galactose to lightly buffered suspensions of anaerobic, non-metabolizing cells of Salmonella typhimurium, specifically induced for the galactose transport system, causes an ... | Proton movements coupled to sugar transport via the galactose transport system in Salmonella typhimurium. We have studied proton movements associated with substrate transport via the galactose transport system in Salmonella typhimurium. The addition of galactose to lightly buffered suspensions of anaerobic, non-metabol... | [
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PMID:14833 | Intramolecularly-quenched fluorescent peptides as fluorogenic substrates ofleucine aminopeptidase and inhibitors of clostridial aminopeptidase. | Fluorogenic oligopeptide derivatives of the type Lys(ABz)-ONBzl, where ABz iso-aminobenzoyl (anthraniloyl), X stands for Ala Phe, or Ala-Ala, and ONBzlis p-nitrobenzyloxy, were synthesized and shown to be hydrolyzed by leucine aminopeptidase. The hydrolysis is accompanied by an increase in fluorescence due to disruptio... | Intramolecularly-quenched fluorescent peptides as fluorogenic substrates ofleucine aminopeptidase and inhibitors of clostridial aminopeptidase. Fluorogenic oligopeptide derivatives of the type Lys(ABz)-ONBzl, where ABz iso-aminobenzoyl (anthraniloyl), X stands for Ala Phe, or Ala-Ala, and ONBzlis p-nitrobenzyloxy, were... | [
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PMID:14834 | Hypoxanthine levels of plasma during hypoxemia in dogs. | Tissue hypoxia was induced in one group of dogs by clamping of the endotracheal tube and in another group by artificial ventilation with a mixture of nitrogen and air. The hypoxanthine concentration of venous and arterial plasma increased significantly during severe hypoxemia. When the hypoxemia was relieved, an increa... | Hypoxanthine levels of plasma during hypoxemia in dogs. Tissue hypoxia was induced in one group of dogs by clamping of the endotracheal tube and in another group by artificial ventilation with a mixture of nitrogen and air. The hypoxanthine concentration of venous and arterial plasma increased significantly during seve... | [
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PMID:14835 | Protective action of timolol in acute myocardial ischemia. | Timolol, a beta-adrenoceptor blocking agent with little or no cardiodepressant activity, was studied in acute myocardial ischemia in cats. Timolol, at a dose of 25 mug/kg, blocked 75 to 80% of the cardiac response to isoproterenol. This dose also significantly reduced heart rate in cats subjected to acute myocardial is... | Protective action of timolol in acute myocardial ischemia. Timolol, a beta-adrenoceptor blocking agent with little or no cardiodepressant activity, was studied in acute myocardial ischemia in cats. Timolol, at a dose of 25 mug/kg, blocked 75 to 80% of the cardiac response to isoproterenol. This dose also significantly ... | [
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PMID:14836 | Studies on the antagonism by raphe lesions of the antinociceptive action of systemic morphine. | In rats, lesions were placed in the dorsal/median raphe (DMR), in the ventral raphe (VR: raphe magnus), in both the dorsal/median and ventral raphe (DMVR) or in the reticular formation (RF). The effect of the lesions on the antinociception and catalepsy produced by 3 doses of morphine (3, 10 and 30 mg/kg) was examined.... | Studies on the antagonism by raphe lesions of the antinociceptive action of systemic morphine. In rats, lesions were placed in the dorsal/median raphe (DMR), in the ventral raphe (VR: raphe magnus), in both the dorsal/median and ventral raphe (DMVR) or in the reticular formation (RF). The effect of the lesions on the a... | [
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PMID:14837 | Attenuation of morphine analgesia in rats with lesions of the locus coeruleus and dorsal raphe nucleus. | The nociceptive reflex activity and analgesic effect of morphine were studied in rats using the hind paw stimulation test. The stimulation threshold was significantly increased in animals with bilateral destruction of the locus coeruleus (LC), and was reduced after lesion of the dorsal raphe nucleus (DR). LC lesions pr... | Attenuation of morphine analgesia in rats with lesions of the locus coeruleus and dorsal raphe nucleus. The nociceptive reflex activity and analgesic effect of morphine were studied in rats using the hind paw stimulation test. The stimulation threshold was significantly increased in animals with bilateral destruction o... | [
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PMID:14838 | Pharmacological characterisation of the presynaptic alpha-adrenoceptor in the rat vas deferens. | The interactions between alpha-adrenoceptor agonists and antagonists on the twitch response of the rat isolated vas deferens to low frequency motor nerve stimulatioh have been examined. Oxymetazoline, clonidine, naphazoline and BAY-1470 caused a concentration-dependent inhibition of the twitch response at concentration... | Pharmacological characterisation of the presynaptic alpha-adrenoceptor in the rat vas deferens. The interactions between alpha-adrenoceptor agonists and antagonists on the twitch response of the rat isolated vas deferens to low frequency motor nerve stimulatioh have been examined. Oxymetazoline, clonidine, naphazoline ... | [
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PMID:14839 | The effect of guanethidine and hydrochlorothiazide on blood pressure and vascular tyrosine hydroxylase activity in the spontaneously hypertensive rat. | The present study examined the effects of antihypertensive drugs (hydrochlorothiazide and guanethidine) on blood pressure and tyrosine hydroxylase (TH) activity in the spontaneously hypertensive rat (SHR). Hydrochlorothiazide (50 mg/kg X 4 days) lowered blood pressure in the SHR to a degree equivalent to that produced ... | The effect of guanethidine and hydrochlorothiazide on blood pressure and vascular tyrosine hydroxylase activity in the spontaneously hypertensive rat. The present study examined the effects of antihypertensive drugs (hydrochlorothiazide and guanethidine) on blood pressure and tyrosine hydroxylase (TH) activity in the s... | [
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PMID:14843 | [Endogenous formation of carcinogenic-N-nitroso compounds in rats after application of drugs and nitrite (author's transl)]. | During the last years in vitro investigations have demonstrated the possibility of nitrosation of different amines and amides including a number of drugs. The aim of the presented investigations was to test whether an endogenous nitrosation of piperazine, Obesin (propyhexedrine), and ephedrine is possible in long term ... | [Endogenous formation of carcinogenic-N-nitroso compounds in rats after application of drugs and nitrite (author's transl)]. During the last years in vitro investigations have demonstrated the possibility of nitrosation of different amines and amides including a number of drugs. The aim of the presented investigations ... | [
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PMID:14844 | Activity of two components of serum ribonuclease under conditions of physical exercise. | Serum ribonuclease activity before and after physical exercise in healthy persons was estimated. It is found that a work load of 6000 kgm/5 min increased ribonuclease activity measured at pH 8.5 and decreased the activity of the same enzyme measured at pH 7.0 in the presence of Zn SO4. The observed changes were more pr... | Activity of two components of serum ribonuclease under conditions of physical exercise. Serum ribonuclease activity before and after physical exercise in healthy persons was estimated. It is found that a work load of 6000 kgm/5 min increased ribonuclease activity measured at pH 8.5 and decreased the activity of the sam... | [
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PMID:14845 | Effect of various factors on the activity of trehalase from the larvae of Sesamia inferens Walker (Insect). | Trehalase from the salivary glands and the midgut of Sesamia inferens showed optimum activity at pH 5.8, and at temperatures of 50 and 60 degrees C respectively. The increase in the incubation period, enzyme concentration, and substrate concentration respectively increased the end-product, the hydrolysis, and the rate ... | Effect of various factors on the activity of trehalase from the larvae of Sesamia inferens Walker (Insect). Trehalase from the salivary glands and the midgut of Sesamia inferens showed optimum activity at pH 5.8, and at temperatures of 50 and 60 degrees C respectively. The increase in the incubation period, enzyme conc... | [
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PMID:14849 | Oxygen and carbon dioxide in the regulation of respiration. | When a sea-level resident ascends to a high altitude, his breathing immediately increases because of hypoxic stimulation of the peripheral chemoreceptors. In many species the aortic bodies are relatively unimportant in this response compared to the carotid bodies. When the subject stays at that altitude, his breathing ... | Oxygen and carbon dioxide in the regulation of respiration. When a sea-level resident ascends to a high altitude, his breathing immediately increases because of hypoxic stimulation of the peripheral chemoreceptors. In many species the aortic bodies are relatively unimportant in this response compared to the carotid bod... | [
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PMID:14850 | New developments in our knowledge of the chemistry of renin. | Although the role of renin in hypertension continues to be incompletely defined, recent progress in the chemistry of renin has been considerable. Extensive purifications of hog kidney renin and the renin-like mouse submaxillary gland enzyme have been achieved. Various inhibitory peptides based on tetradecapeptide renin... | New developments in our knowledge of the chemistry of renin. Although the role of renin in hypertension continues to be incompletely defined, recent progress in the chemistry of renin has been considerable. Extensive purifications of hog kidney renin and the renin-like mouse submaxillary gland enzyme have been achieved... | [
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PMID:14851 | [Enzymatic processes and chemical composition of the cecal contents of swine fed carbohydrates from different plants]. | A considerable amount of low-molecular acids (14.5-18.2 meqv/100 ml) is formed in the coecum in consequence of fermentation of cellulose, starch, and other components of chyme with microflora. The total concentration and molecular per cent ratio of the acetic, propionic, butyric, and lactic acids depended on the compos... | [Enzymatic processes and chemical composition of the cecal contents of swine fed carbohydrates from different plants]. A considerable amount of low-molecular acids (14.5-18.2 meqv/100 ml) is formed in the coecum in consequence of fermentation of cellulose, starch, and other components of chyme with microflora. The tota... | [
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PMID:14852 | Time dependence of the effect of splenectomy on graft-versus-host reactivity of lymph node cells. | Changes in cell-mediated reactivity of lymph node cells at various intervals after splenectomy were investigated in three assays measuring the GVH reactivity of parental cells in F1 hybrids --splenomegaly test in very young recipients and popliteal lymph node enlargement assay in adults measuring the proliferative comp... | Time dependence of the effect of splenectomy on graft-versus-host reactivity of lymph node cells. Changes in cell-mediated reactivity of lymph node cells at various intervals after splenectomy were investigated in three assays measuring the GVH reactivity of parental cells in F1 hybrids --splenomegaly test in very youn... | [
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PMID:14858 | Aversive prenatal stimulation: effects on behavioral, biochemical, and somatic ontogeny in the rat. | Electric foot shock administered to pregnant rats altered the ontogeny of spontaneous motor activity in their pups. Prenatally stimulated (PMS) offspring were more active than controls on Days 1-10 but less active during the 3rd postpartum week. The age of peak activity, a major developmental landmark, occurred in PMS ... | Aversive prenatal stimulation: effects on behavioral, biochemical, and somatic ontogeny in the rat. Electric foot shock administered to pregnant rats altered the ontogeny of spontaneous motor activity in their pups. Prenatally stimulated (PMS) offspring were more active than controls on Days 1-10 but less active during... | [
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PMID:14859 | Decreased rat hepatic guanylate cyclase activity in streptozotocin-induced diabetes mellitus. | Guanylate cyclase is found in virtually all cells, but its physiologic role and the effect of hormones on its activity have not been clarified. Hepatic soluble guanylate cyclase activity (37,000 g supernatant) in rats with diabetes-mellitus-like syndrome induced by streptozotocin, 65 mg./kg. i.v., was 140 +/- 8 pmoles ... | Decreased rat hepatic guanylate cyclase activity in streptozotocin-induced diabetes mellitus. Guanylate cyclase is found in virtually all cells, but its physiologic role and the effect of hormones on its activity have not been clarified. Hepatic soluble guanylate cyclase activity (37,000 g supernatant) in rats with dia... | [
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PMID:14860 | Aspects of carbohydrate metabolism in developing brain. | This review considers carbohydrate metabolism in the developing brain, in particular the proportion of glucose metabolized via the pentose phosphate pathway. Although small in amount, this fraction serves a vital rôle in some aspects of brain function. Evidence is presented that the pentose phosphate pathway subserves ... | Aspects of carbohydrate metabolism in developing brain. This review considers carbohydrate metabolism in the developing brain, in particular the proportion of glucose metabolized via the pentose phosphate pathway. Although small in amount, this fraction serves a vital rôle in some aspects of brain function. Evidence is... | [
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PMID:14861 | Serum gastrin levels before and after 6 weeks of cimetidine therapy in patients with duodenal ulcer. | Fasting serum gastrins were carried out at the beginning and end of a 6-week double-blind trial of cimetidine and placebo in 30 patients with duodenal ulcer. Cimetidine did not cause any significant change in fasting serum gastrin levels after 6 weeks of therapy. | Serum gastrin levels before and after 6 weeks of cimetidine therapy in patients with duodenal ulcer. Fasting serum gastrins were carried out at the beginning and end of a 6-week double-blind trial of cimetidine and placebo in 30 patients with duodenal ulcer. Cimetidine did not cause any significant change in fasting se... | [
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PMID:14862 | The effect of the alkaline tide on serum-ionized calcium concentration in man. | The effect of the gastric alkaline tide on serum-ionized calcium levels was determined in human subjects. Gastric acid seretion was stimulated by a standard steak meal, human synthetic gastrin, and betazole hydrochloride. Ionized calcium levels fell to a similar extent after each stimulus. The mean decrease in calcium ... | The effect of the alkaline tide on serum-ionized calcium concentration in man. The effect of the gastric alkaline tide on serum-ionized calcium levels was determined in human subjects. Gastric acid seretion was stimulated by a standard steak meal, human synthetic gastrin, and betazole hydrochloride. Ionized calcium lev... | [
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PMID:14865 | Lower esophageal sphincter pressure in cirrhotic men with ascites: before and after diuresis. | Lower esophageal sphincter pressure (LESP) was measured in 10 biopsy-proved cirrhotics with esophageal varices and tense ascites before and after diuresis to evaluate of ascites might play in the development of variceal bleeding. In the 10 cirrhotic men studied, basal LESP was 30.9 +/- 1.7 mm Hg before and 22.7 +/- 1.3... | Lower esophageal sphincter pressure in cirrhotic men with ascites: before and after diuresis. Lower esophageal sphincter pressure (LESP) was measured in 10 biopsy-proved cirrhotics with esophageal varices and tense ascites before and after diuresis to evaluate of ascites might play in the development of variceal bleedi... | [
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... |
PMID:14866 | Small intestinal injury in the graft versus host reaction: an innocent bystander phenomenon. | Marked morphological and functional damage to the small intestine occurs during the graft versus host reaction (GVHR); the structural lesion is characterized by crypt hypertrophy and villus shortening. The purpose of this study was to determine whether the intestine is injured in the GVHR as an antigenic target of the ... | Small intestinal injury in the graft versus host reaction: an innocent bystander phenomenon. Marked morphological and functional damage to the small intestine occurs during the graft versus host reaction (GVHR); the structural lesion is characterized by crypt hypertrophy and villus shortening. The purpose of this study... | [
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PMID:14867 | Stimulatory (H1) and inhibitory (H2) histamine receptors in gallbladder muscle. | The nature of histamine receptors in gallbladder muscle and examined using specific histamine-receptor agonists and antagonists. The H2-receptor antagonist, metiamide, augmented the contractile response to histamine indicating that gallbladder muscle possessed stimulatory H1 receptors and inhibitory H2 receptors. The i... | Stimulatory (H1) and inhibitory (H2) histamine receptors in gallbladder muscle. The nature of histamine receptors in gallbladder muscle and examined using specific histamine-receptor agonists and antagonists. The H2-receptor antagonist, metiamide, augmented the contractile response to histamine indicating that gallblad... | [
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PMID:14870 | [Pharmacological analysis of effects of perimetazine on isolated smooth muscle]. | Effects of perimetazine on the motility of the isolated smooth muscle of guinea pig (ileum, taenia coli, uterus, vas deferens and trachea) and the ileum of rabbit were studied. The results obtained are as follows: Perimetazine showed a specific antihistamine, antiadrenaline and antiserotonin action. Moreover, antiacety... | [Pharmacological analysis of effects of perimetazine on isolated smooth muscle]. Effects of perimetazine on the motility of the isolated smooth muscle of guinea pig (ileum, taenia coli, uterus, vas deferens and trachea) and the ileum of rabbit were studied. The results obtained are as follows: Perimetazine showed a spe... | [
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PMID:14871 | [Findings in the gastric mucosa and gastric secretion in rats treated with methyl O-(4-hydroxy-3-methoxycinnamoyl)reserpate (CD-3400) and reserpine derivatives]. | CD-3400 developed by Nippon Chemiphar Co. Ltd., is a new antihypertensive agent belonging to the class of rauwolfa alkaloids. Influence of the agent on gastric mucosa, healing process of acetic acid-induced gastric ulcer and gastric juice in rats was investigated and compared with effects of reserpine and rescinnamine.... | [Findings in the gastric mucosa and gastric secretion in rats treated with methyl O-(4-hydroxy-3-methoxycinnamoyl)reserpate (CD-3400) and reserpine derivatives]. CD-3400 developed by Nippon Chemiphar Co. Ltd., is a new antihypertensive agent belonging to the class of rauwolfa alkaloids. Influence of the agent on gastri... | [
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PMID:14872 | [Effects of methyl O-(4-hydroxy-3-methoxycinnamoly)reserpate (CD-3400) on the peripheral nervous system: especially on the smooth muscle organs]. | Effects of methyl O-(4-hydroxy-3-methoxycinnamoyl) reserpate (CD-3400), a new antihypertensive agent, on the peripheral nervous system in mice, rats and guinea pigs were investigated and compared with effects of reserpine and rescinnamine. Oral administration of CD-3400 in doses from 40 to 320 mg/kg revealed a miotic a... | [Effects of methyl O-(4-hydroxy-3-methoxycinnamoly)reserpate (CD-3400) on the peripheral nervous system: especially on the smooth muscle organs]. Effects of methyl O-(4-hydroxy-3-methoxycinnamoyl) reserpate (CD-3400), a new antihypertensive agent, on the peripheral nervous system in mice, rats and guinea pigs were inve... | [
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PMID:14873 | Separation and properties of alpha-mannosidase and mannanase from the basidiomycete Phellinus abietis. | Proteins of a crude enzyme preparation obtained from the cultivation medium of the basidiomycete Phellinus abietis were separated by gel filtration and ion-exchange chromatography. The preparation contained a minimum of three enzymes capable of splitting alpha-D-mannosidic bonds: alpha-mannosidase, exomannanase, and en... | Separation and properties of alpha-mannosidase and mannanase from the basidiomycete Phellinus abietis. Proteins of a crude enzyme preparation obtained from the cultivation medium of the basidiomycete Phellinus abietis were separated by gel filtration and ion-exchange chromatography. The preparation contained a minimum ... | [
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PMID:14874 | [A new method for the clinical determination of urinary porphobilinogen and delta-aminolevulinic acid]. | A new method has been developed for clinical determination of porphobilinogen and delta-aminolevulinic acid in urine. Compared with the method of Mauzerall and Granick, being the most commonly used method for clinical application, there is an essential reduction of work and needed time. During the flow of 0.5 ml urine ... | [A new method for the clinical determination of urinary porphobilinogen and delta-aminolevulinic acid]. A new method has been developed for clinical determination of porphobilinogen and delta-aminolevulinic acid in urine. Compared with the method of Mauzerall and Granick, being the most commonly used method for clinica... | [
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PMID:14875 | [The effect of anesthesia on the postoperative behavior of liver enzymes and protein fractions]. | Liver tests were performed postoperatively on 25 women with "healthy" livers. Patients were divided into 3 groups according to the type of anesthesia used: 1. halothane; 2. neuroleptic; 3. peridural. In all 3 groups the variations in serum proteins and liver enzymes were similar up to the 15th postoperative day. Variat... | [The effect of anesthesia on the postoperative behavior of liver enzymes and protein fractions]. Liver tests were performed postoperatively on 25 women with "healthy" livers. Patients were divided into 3 groups according to the type of anesthesia used: 1. halothane; 2. neuroleptic; 3. peridural. In all 3 groups the var... | [
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PMID:14890 | Bacteriostatic effect of human milk and bovine colostrum on Escherichia coli: importance of bicarbonate. | At pH 7.4 and in the presence of NaHCO3, human milk and bovine colostrum inhibited the growth of Escherichia coli O111. Adding sufficient iron to saturate the iron-binding capacity of the lactoferrin present in the milk or colostrum prevented bacteriostasis. At pH 6.8 neither molk nor colostrum inhibited E. coli 0111. ... | Bacteriostatic effect of human milk and bovine colostrum on Escherichia coli: importance of bicarbonate. At pH 7.4 and in the presence of NaHCO3, human milk and bovine colostrum inhibited the growth of Escherichia coli O111. Adding sufficient iron to saturate the iron-binding capacity of the lactoferrin present in the ... | [
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PMID:14891 | Reproduction of the eosinopenia of acute infection by passive transfer of a material obtained from inflammatory exudate. | Studies of the eosinopenic effect of acute inflammation were conducted in mice previously rendered eosinophilic with trichinosis. Exudate removed from a pneumococcal abscess contained material (eosinopenic factor [EF]) capable of causing eosinopenia of 4- to 24-h duration when injected intraperitoneally into eosinophil... | Reproduction of the eosinopenia of acute infection by passive transfer of a material obtained from inflammatory exudate. Studies of the eosinopenic effect of acute inflammation were conducted in mice previously rendered eosinophilic with trichinosis. Exudate removed from a pneumococcal abscess contained material (eosin... | [
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PMID:14892 | Magnesium-dependent adenosine triphosphatase as a marker enzyme for the plasma membrane of human polymorphonuclear leukocytes. | The adenosine triphosphatase (ATPase) activities of human polymorphonuclear leukocytes (PMNL) were studied with an assay that monitored the release of 32P-labeled inorganic pyrophosphate (32P1) from gamma-[32P]adenosine 5'-triphosphate (ATP). In cell homogenates, (Na+ + K+)-sensitive, ouabain-inhibitable ATPase compris... | Magnesium-dependent adenosine triphosphatase as a marker enzyme for the plasma membrane of human polymorphonuclear leukocytes. The adenosine triphosphatase (ATPase) activities of human polymorphonuclear leukocytes (PMNL) were studied with an assay that monitored the release of 32P-labeled inorganic pyrophosphate (32P1)... | [
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PMID:14893 | Levan and levansucrase of Actinomyces viscosus. | A levansucrase was demonstrated in the growth medium and in association with the cell surface of Actinomyces viscosus. The amount of enzyme produced relative to cell density is not significantly affected by the growth conditions. Sugar alcohols inhibit growth of the cells. The levansucrase hydrolyzes sucrose to produce... | Levan and levansucrase of Actinomyces viscosus. A levansucrase was demonstrated in the growth medium and in association with the cell surface of Actinomyces viscosus. The amount of enzyme produced relative to cell density is not significantly affected by the growth conditions. Sugar alcohols inhibit growth of the cells... | [
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PMID:14896 | Tumorigenicity of human hematopoietic cell lines in athymic nude mice. | Human hematopoietic cell lines, which had been classified on the basis of studies on clonality, and morphological, chromosomal and functional parameters as lymphoblastoid cell lines (LCL) of presumed non-neoplastic origin, and lymphoma, myeloma and leukemia lines of proven malignant origin, were tested for tumorigenic ... | Tumorigenicity of human hematopoietic cell lines in athymic nude mice. Human hematopoietic cell lines, which had been classified on the basis of studies on clonality, and morphological, chromosomal and functional parameters as lymphoblastoid cell lines (LCL) of presumed non-neoplastic origin, and lymphoma, myeloma and ... | [
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PMID:14897 | Studies on Epstein-Barr virus-related antigens. II. Biochemical properties of soluble antigen in Raji Burkitt lymphoma cells. | Biochemical properties of Epstein-Barr virus (EBV)-related soluble antigen in non-producer Raji Burkitt lymphoblastoid cells, assayed by the indirect single radial immunodiffusion (ISRD) test, were investigated. The soluble ISRD antigen retained activity even after exposure to a temperature of 80 degrees C. The antigen... | Studies on Epstein-Barr virus-related antigens. II. Biochemical properties of soluble antigen in Raji Burkitt lymphoma cells. Biochemical properties of Epstein-Barr virus (EBV)-related soluble antigen in non-producer Raji Burkitt lymphoblastoid cells, assayed by the indirect single radial immunodiffusion (ISRD) test, w... | [
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PMID:14898 | Purification of several proteolytic enzymes by tosyl- and carbobenzoxy-triethylene-tetramine-sepharoses. | Tosyl-triethylenetetramine-Sepharose (Tos-T-Sepharose) and carbenzoxytriethylenetetramine-Sepharose (Z-T-Sepharose) were found to be adsorbents utilizable in the purification of several microbial and animal proteases. The former Sepharose derivative adsorbed alpha-chymotrypsin, trypsin, subtilisin, thermolysin and neut... | Purification of several proteolytic enzymes by tosyl- and carbobenzoxy-triethylene-tetramine-sepharoses. Tosyl-triethylenetetramine-Sepharose (Tos-T-Sepharose) and carbenzoxytriethylenetetramine-Sepharose (Z-T-Sepharose) were found to be adsorbents utilizable in the purification of several microbial and animal protease... | [
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PMID:14899 | The acylation of bovine serum albumin with diacetylcycloserine. | The reaction of the amino groups of bovine serum albumin (BSA) with diacetylcycloserine (I) at pH 7.2-9.0 proceeded with both acylation by the diacetyl-beta-aminooxy-D-alanyl (DAA) group and acetylation. The number of DAA groups was determined by their conversion to cycloserine (III) which can be accurately measured in... | The acylation of bovine serum albumin with diacetylcycloserine. The reaction of the amino groups of bovine serum albumin (BSA) with diacetylcycloserine (I) at pH 7.2-9.0 proceeded with both acylation by the diacetyl-beta-aminooxy-D-alanyl (DAA) group and acetylation. The number of DAA groups was determined by their con... | [
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PMID:14900 | Iodinated radiological contrast media as radiosensitizers. | This paper describes the radiosensitizing effects of diatrizoic (DA) and iothalamic (ITA) acids and of iodipamide (IP) on the survival of E coli B/r irradiated with X-rays and with high-intensity electron pulses. All compounds at concentrations between 10 and 50 mM display a strong sensitizing effect in the presence of... | Iodinated radiological contrast media as radiosensitizers. This paper describes the radiosensitizing effects of diatrizoic (DA) and iothalamic (ITA) acids and of iodipamide (IP) on the survival of E coli B/r irradiated with X-rays and with high-intensity electron pulses. All compounds at concentrations between 10 and 5... | [
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PMID:14906 | The activity and distribution of gamma-glutamyl transpeptidase (y-GT) in human foetal organs. | The activity and distribution of y-GT was investigated in a number of organs from human foetuses aged from 14 to 24 weeks post menstruationem. Over this period, enzyme activity increased in the kidney, pancreas and thymus, but decreased in the small intestine. No trend could be established for the liver, although activ... | The activity and distribution of gamma-glutamyl transpeptidase (y-GT) in human foetal organs. The activity and distribution of y-GT was investigated in a number of organs from human foetuses aged from 14 to 24 weeks post menstruationem. Over this period, enzyme activity increased in the kidney, pancreas and thymus, but... | [
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PMID:14904 | Subcellular distribution of pyridoxal kinase in ox retina. | PL kinase activity has been determined in primary and secondary subcellular fractions of ox retina. Enzymic activity is predominantly located in the soluble fraction (S3). About 65% of the recovered PL kinase activity of crude mitochondria is released from synaptosomal fraction after hypoosmotic treatment. PL kinase ac... | Subcellular distribution of pyridoxal kinase in ox retina. PL kinase activity has been determined in primary and secondary subcellular fractions of ox retina. Enzymic activity is predominantly located in the soluble fraction (S3). About 65% of the recovered PL kinase activity of crude mitochondria is released from syna... | [
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PMID:14919 | Purification and properties of glutamate synthase from Thiobacillus thioparus. | Glutamate synthase was purified about 250-fold from Thiobacillus thioparus and was characterized. The molecular weight was estimated as 280,000 g/mol. The enzyme showed absorption maxima at 280, 380, and 450 nm and was inhibited by Atebrin, suggesting that T. thioparus glutamate synthase is a flavoprotein. The enzyme a... | Purification and properties of glutamate synthase from Thiobacillus thioparus. Glutamate synthase was purified about 250-fold from Thiobacillus thioparus and was characterized. The molecular weight was estimated as 280,000 g/mol. The enzyme showed absorption maxima at 280, 380, and 450 nm and was inhibited by Atebrin, ... | [
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PMID:14920 | Pyrrolidone carboxylyl peptidase in Streptococcus cremoris: dependence on an interaction with membrane components. | A study of the distribution of pyrrolidone carboxylyl peptidase (PCP) activity among cell fractions of Streptococcus cremoris HP revealed that this enzyme is associated with a particulate fraction, which mainly consists of membrane material. This location could only be established using a gentle nonmechanical method fo... | Pyrrolidone carboxylyl peptidase in Streptococcus cremoris: dependence on an interaction with membrane components. A study of the distribution of pyrrolidone carboxylyl peptidase (PCP) activity among cell fractions of Streptococcus cremoris HP revealed that this enzyme is associated with a particulate fraction, which m... | [
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... |
PMID:14921 | Partial purification of the Escherichia coli K-12 mec+ deoxyribonucleic acid-cytosine methylase: in vitro methylation completely protects bacteriophage lambda deoxyribonucleic acid against cleavage by R-EcoRII. | A procedure is described for the partial purification of the deoxyribonucleic acid (DNA)-cytosine methylases controlled by the RII plasmid and by the Escherichia coli mec+ gene. The two enzymes exhibit similar but distinct chromatographic behavior on diethylaminoethyl-cellulose and phosphocellulose. Preliminary studies... | Partial purification of the Escherichia coli K-12 mec+ deoxyribonucleic acid-cytosine methylase: in vitro methylation completely protects bacteriophage lambda deoxyribonucleic acid against cleavage by R-EcoRII. A procedure is described for the partial purification of the deoxyribonucleic acid (DNA)-cytosine methylases ... | [
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PMID:14922 | Sterol 24(28) methylene reductase in Saccharomyces cerevisiae. | Optimal conditions for the 24(28)methylene reductase were obtained. The enzyme assay provided for unusually high activity; the Km was determined to be 10.8 mum. The enzyme activity was increased in cells grown with ethanol as the substrate. | Sterol 24(28) methylene reductase in Saccharomyces cerevisiae. Optimal conditions for the 24(28)methylene reductase were obtained. The enzyme assay provided for unusually high activity; the Km was determined to be 10.8 mum. The enzyme activity was increased in cells grown with ethanol as the substrate. | [
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PMID:14923 | Ornithine transcarbamylase from Salmonella typhimurium: purification, subunit composition, kinetic analysis, and immunological cross-reactivity. | Ornithine transcarbamylase (OTCase) was purified to hemogeneity from a derepressed strain of Salmonella typhimurium. The optimal pH for enzyme activity is 8.0. The molecular weight of the enzyme was calculated to be 116,000, based on measurements of the sedimentation coefficient by sucrose gradient ultracentrifugation ... | Ornithine transcarbamylase from Salmonella typhimurium: purification, subunit composition, kinetic analysis, and immunological cross-reactivity. Ornithine transcarbamylase (OTCase) was purified to hemogeneity from a derepressed strain of Salmonella typhimurium. The optimal pH for enzyme activity is 8.0. The molecular w... | [
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PMID:14924 | Properties of an inducible extracellular neuraminidase from an Arthrobacter isolate. | The elective isolation of a soil microorganism, tentatively assigned to the genus Arthrobacter, which produced an extracellular neuraminidase is described. The secretion of neuraminidase from washed cells in minimal medium required the presence of sialo-containing glycoproteins, whereas free N-acetyl-neuraminic asid of... | Properties of an inducible extracellular neuraminidase from an Arthrobacter isolate. The elective isolation of a soil microorganism, tentatively assigned to the genus Arthrobacter, which produced an extracellular neuraminidase is described. The secretion of neuraminidase from washed cells in minimal medium required the... | [
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PMID:14925 | Motility of Mycoplasma pneumoniae. | Cell of Mycoplasma pneumoniae FH gliding on a glass surface in liquid medium were examined by microscopic observation and quantitatively by microcinematography (30 frames per min). Comparisons were made only within the individual experiments. The cells moved in an irregular pattern with numerous narrow bends and circle... | Motility of Mycoplasma pneumoniae. Cell of Mycoplasma pneumoniae FH gliding on a glass surface in liquid medium were examined by microscopic observation and quantitatively by microcinematography (30 frames per min). Comparisons were made only within the individual experiments. The cells moved in an irregular pattern wi... | [
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PMID:14926 | Purification and some properties of an extracellular alpha-amylase from Bacteroides amylophilus. | A medium was developed to obtain maximum yields of extracellular amylase from Bacteroides amylophilus 70. Crude enzyme preparation, obtained by ammonium sulfate precipitation of cell-free broth, contained six amylolytic isoenzymes that were detected by isoelectric focusing and polyacrylamide gel electrophoresis. One o... | Purification and some properties of an extracellular alpha-amylase from Bacteroides amylophilus. A medium was developed to obtain maximum yields of extracellular amylase from Bacteroides amylophilus 70. Crude enzyme preparation, obtained by ammonium sulfate precipitation of cell-free broth, contained six amylolytic is... | [
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PMID:14927 | Formation of glutamine from [13n]ammonia, [13n]dinitrogen, and [14C]glutamate by heterocysts isolated from Anabaena cylindrica. | A method is described for the isolation of metabolically active heterocysts from Anabaena cylindrica. These isolated heterocysts accounted for up to 34% of the acetylene-reducing activity of whole filaments and had a specific activity of up to 1,560 nmol of C2H4 formed per mg of heterocyst chlorphyll per min. Activity ... | Formation of glutamine from [13n]ammonia, [13n]dinitrogen, and [14C]glutamate by heterocysts isolated from Anabaena cylindrica. A method is described for the isolation of metabolically active heterocysts from Anabaena cylindrica. These isolated heterocysts accounted for up to 34% of the acetylene-reducing activity of w... | [
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PMID:14928 | Measurement of the pH of frozen buffer solutions by using pH indicators. | A method was established to estimate the pH change of several buffers solutions on freezing by using a combination of pH indicators. Among more than 30 buffers solutions examined, almost half exhibited a pH change in the temperature range between freezing point and 220 degrees K; the results were tabulated. Glycerol wa... | Measurement of the pH of frozen buffer solutions by using pH indicators. A method was established to estimate the pH change of several buffers solutions on freezing by using a combination of pH indicators. Among more than 30 buffers solutions examined, almost half exhibited a pH change in the temperature range between ... | [
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PMID:14929 | Mathematical analysis of ligand-induced monomerization and dimerization in the monomer dimer equilibrium of proteins. Application to D-amino acid oxidase. | We have mathematically analyzed ligand-induced monomerization and dimerization in a protein monomer-dimer equilibrium system, in which the monomer has one and the dimer two binding sites. These dimer sites have the same binding constants for the first ligand but may cooperatively interact when one of them is occupied b... | Mathematical analysis of ligand-induced monomerization and dimerization in the monomer dimer equilibrium of proteins. Application to D-amino acid oxidase. We have mathematically analyzed ligand-induced monomerization and dimerization in a protein monomer-dimer equilibrium system, in which the monomer has one and the di... | [
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