id stringlengths 7 10 | title stringlengths 8 354 | content stringlengths 91 4.1k | contents stringlengths 164 4.24k | embedding listlengths 384 384 |
|---|---|---|---|---|
PMID:17495 | A radioimmunoassay for the R-type binders of cobalamin. | A radioimmunoassay of R-type binders of cobalmin was devised and tested. The assay incorporated an antibody against purified human salivary R binder as the binding reagent. The labeled ligand was cyano[57Co]cobalamin bound to the R binder of pooled human saliva. The standard source of unlabeled ligand was also from hum... | A radioimmunoassay for the R-type binders of cobalamin. A radioimmunoassay of R-type binders of cobalmin was devised and tested. The assay incorporated an antibody against purified human salivary R binder as the binding reagent. The labeled ligand was cyano[57Co]cobalamin bound to the R binder of pooled human saliva. T... | [
-0.0619240440428257,
0.04444415122270584,
-0.023962195962667465,
0.02003895305097103,
0.033324602991342545,
-0.0618961825966835,
0.08540809899568558,
0.028915144503116608,
-0.06462971866130829,
0.009586341679096222,
0.027142083272337914,
-0.08365345746278763,
0.007769296877086163,
0.040137... |
PMID:17496 | An improved method for the determination of acetylcholinesterase activity in rectal biopsy tissue from patients with Hirschsprung's disease. | A method is described for the assay of acetylcholinesterase in tissue samples using the selective cholinesterase inhibitor, lysivane (10-(alpha-diethylaminopropyl) phenothiazine hydrochloride). Significantly increased enzyme activity is found in rectal biopsy specimens from patients with Hirschsprung's disease (p less ... | An improved method for the determination of acetylcholinesterase activity in rectal biopsy tissue from patients with Hirschsprung's disease. A method is described for the assay of acetylcholinesterase in tissue samples using the selective cholinesterase inhibitor, lysivane (10-(alpha-diethylaminopropyl) phenothiazine h... | [
-0.019741641357541084,
0.030727334320545197,
0.001625854056328535,
0.0350150391459465,
-0.04233088344335556,
-0.023293673992156982,
0.06728911399841309,
0.07937245070934296,
0.006064915098249912,
-0.06319966167211533,
-0.006492640823125839,
-0.04077491909265518,
-0.006749049760401249,
0.00... |
PMID:17497 | Respiratory acidosis and alkalosis. | The physiology of respiratory control of acid-base balance is reviewed. The pathophysiological mechanisms during hypercapnia and hypocapnia are discussed in the light of the causes and clinical manifestations of these disturbances. In addition to the role of the kidney in the compensatory processes of these disturbance... | Respiratory acidosis and alkalosis. The physiology of respiratory control of acid-base balance is reviewed. The pathophysiological mechanisms during hypercapnia and hypocapnia are discussed in the light of the causes and clinical manifestations of these disturbances. In addition to the role of the kidney in the compens... | [
-0.032616026699543,
0.0012662066146731377,
0.008263051509857178,
0.05790247023105621,
-0.03819774463772774,
-0.04336053505539894,
0.09090903401374817,
0.01576807163655758,
-0.018973270431160927,
0.014184963889420033,
0.0003370670892763883,
-0.04906520992517471,
-0.008500033058226109,
0.073... |
PMID:17498 | Metabolic acidosis and alkalosis. | The factors controlling renal bicarbonate reabsorption and acid excretion under normal conditions and in the presence of metabolic acidosis and alkalosis are reviewed. The methods used to assess distal acidification and its limitations are also discussed. Measurement of urinary pCO2 in maximally alkaline urine (pH grea... | Metabolic acidosis and alkalosis. The factors controlling renal bicarbonate reabsorption and acid excretion under normal conditions and in the presence of metabolic acidosis and alkalosis are reviewed. The methods used to assess distal acidification and its limitations are also discussed. Measurement of urinary pCO2 in... | [
-0.044429194182157516,
-0.019146757200360298,
0.04333169385790825,
0.06161624193191528,
-0.041596610099077225,
-0.02228560484945774,
0.05943676456809044,
0.028677482157945633,
-0.03012891300022602,
0.0014498542295768857,
0.030830005183815956,
-0.1147574707865715,
0.019882412627339363,
0.10... |
PMID:17500 | Methadone maintenance: effect of urinary pH on renal clearance in chronic high and low doses. | The subjects were 12 male patients stabilized on methadone for many months or years. A comparison was made of the plasma levels and renal clearance of methadone between patients on "high" doses (80 to 110 mg/day) and those on "low" doses (15 to 40 mg/day). A general trend to higher renal clearance was seen in the "high... | Methadone maintenance: effect of urinary pH on renal clearance in chronic high and low doses. The subjects were 12 male patients stabilized on methadone for many months or years. A comparison was made of the plasma levels and renal clearance of methadone between patients on "high" doses (80 to 110 mg/day) and those on ... | [
-0.017983710393309593,
0.020394116640090942,
0.022835655137896538,
0.014235789887607098,
0.04833385348320007,
-0.02116798236966133,
0.07728005945682526,
0.001120763598009944,
-0.02350548282265663,
-0.027852917090058327,
0.023115597665309906,
-0.05117715150117874,
0.07106576859951019,
0.074... |
PMID:17501 | The crystalline salts of calcium bilirubinate in human gallstones. | 1. The acid, neutral and "intermediate" salts of calcium bilirubinate have been synthesized. 2. All are crystalline, and the intermediate salt which has 1 1/2 molecules of bilirubin per calcium atom probably has a crystal structure containing molecules of both acid and neutral salts. 3. The acid or intermediate salts h... | The crystalline salts of calcium bilirubinate in human gallstones. 1. The acid, neutral and "intermediate" salts of calcium bilirubinate have been synthesized. 2. All are crystalline, and the intermediate salt which has 1 1/2 molecules of bilirubin per calcium atom probably has a crystal structure containing molecules ... | [
-0.03662952780723572,
0.00011859197547892109,
-0.0050782738253474236,
-0.007895737886428833,
-0.031033137813210487,
-0.04057929664850235,
0.06270027905702591,
0.06132883578538895,
-0.01072512473911047,
-0.0007409279351122677,
0.04308170825242996,
-0.14078304171562195,
0.021220432594418526,
... |
PMID:17512 | Autoimmunity, oncornaviruses, and lymphomagenesis. | The interactions between aberrant immune responses and C-type oncornaviruses in mice are complex. These viruses may be activated during certain immune responses, e.g., histocompatibility reactions, in the face of chronic immunosuppression. Oncornaviruses, themselves, may induce autoaggressive cell-mediated responses in... | Autoimmunity, oncornaviruses, and lymphomagenesis. The interactions between aberrant immune responses and C-type oncornaviruses in mice are complex. These viruses may be activated during certain immune responses, e.g., histocompatibility reactions, in the face of chronic immunosuppression. Oncornaviruses, themselves, m... | [
-0.025372039526700974,
0.038575004786252975,
0.005138068925589323,
0.051382604986429214,
-0.009933583438396454,
-0.005608037114143372,
0.09962346404790878,
0.056832145899534225,
-0.05386989563703537,
-0.03277238830924034,
-0.01063807588070631,
-0.03601790592074394,
0.009303598664700985,
-0... |
PMID:17513 | Predictability of arterial pH and PCO2 from right atrial blood samples in experimental animal. | Arterial and right atrial blood samples were drawn simultaneously under acutely changing acid-base and ventilatory conditions in a series of experiments carried out in nine pigs. The pH, PCO2, bicarbonate concentration and base excess from arterial and right atrial blood are compared. The predictability of the arterial... | Predictability of arterial pH and PCO2 from right atrial blood samples in experimental animal. Arterial and right atrial blood samples were drawn simultaneously under acutely changing acid-base and ventilatory conditions in a series of experiments carried out in nine pigs. The pH, PCO2, bicarbonate concentration and ba... | [
-0.0638338029384613,
0.054696887731552124,
-0.009122360497713089,
0.03626158460974693,
0.0465904176235199,
0.014927643351256847,
0.09539473801851273,
0.03614955395460129,
-0.051109202206134796,
0.02824363484978676,
0.02002877928316593,
-0.0877566859126091,
-0.017372526228427887,
0.04036784... |
PMID:17516 | Fiberoptic bronchoscopy and culture bacteria from the lower respiratory. | Forty-five specimens were obtained by sequential translaryngeal aspiration and fiberoptic bronchoscopy from 31 clinically unifected patients with lung cancer in order to evaluate the reliability of routine fiberoptic bronchoscopy for culture of the lower respiratory tract. Bacteria were recovered brom 98 percent (44) o... | Fiberoptic bronchoscopy and culture bacteria from the lower respiratory. Forty-five specimens were obtained by sequential translaryngeal aspiration and fiberoptic bronchoscopy from 31 clinically unifected patients with lung cancer in order to evaluate the reliability of routine fiberoptic bronchoscopy for culture of th... | [
0.04026582092046738,
0.020377974957227707,
-0.019714806228876114,
-0.00169873156119138,
0.025487931445240974,
-0.02922571264207363,
0.034845251590013504,
0.051356930285692215,
-0.018380627036094666,
0.02971540577709675,
-0.00576868187636137,
-0.058579836040735245,
0.0032205155584961176,
0.... |
PMID:17517 | Patterns of antipsychotic drug use in four Southeastern state hospitals. | The drug prescriptions of patients in the four mental hospitals of a state were obtained as of a specific date and subjected to various analyses. The results disclose a high frequency of antiparkinson drug orders (41.5% of the patients), their relationship to polypharmacy (30% of the antipsychotic drug prescriptions we... | Patterns of antipsychotic drug use in four Southeastern state hospitals. The drug prescriptions of patients in the four mental hospitals of a state were obtained as of a specific date and subjected to various analyses. The results disclose a high frequency of antiparkinson drug orders (41.5% of the patients), their rel... | [
-0.03697280213236809,
-0.015147565864026546,
0.000587611400987953,
-0.021647613495588303,
0.021451711654663086,
0.07727425545454025,
0.05779054015874863,
0.048729151487350464,
-0.027519740164279938,
-0.041131939738988876,
-0.00468652555719018,
0.02725021168589592,
0.00035304808989167213,
0... |
PMID:17514 | The ventilatory response in uncomplicated diabetic ketoacidosis. | The ventilatory response to uncomplicated sub-acute metabolic acidosis was studied by measuring arterial blood CO2 tension (PaCO2) and pH in 27 episodes of diabetic ketoacidosis without coexisting lactic acidosis. From those data, regression equations and 95% confidence bands were calculated for the relations between P... | The ventilatory response in uncomplicated diabetic ketoacidosis. The ventilatory response to uncomplicated sub-acute metabolic acidosis was studied by measuring arterial blood CO2 tension (PaCO2) and pH in 27 episodes of diabetic ketoacidosis without coexisting lactic acidosis. From those data, regression equations and... | [
-0.047966405749320984,
0.06770144402980804,
0.010815318673849106,
0.056594766676425934,
-0.009503817185759544,
0.011811927892267704,
0.06787505745887756,
0.04764380678534508,
-0.04072394222021103,
-0.0013644201681017876,
0.003800807986408472,
-0.06855560094118118,
-0.014266517013311386,
0.... |
PMID:17520 | Isolation and identification of the major metabolite of albuterol in human urine. | The major urinary metabolite of albuterol in man was isolated and purified by ion-exchange chromatography and countercurrent distribution. On the basis of proton magnetic resonance, infrared, and mass-spectral analysis, enzymic hydrolysis, and assay of inorganic sulfate after acid hydrolysis, the metabolite has been id... | Isolation and identification of the major metabolite of albuterol in human urine. The major urinary metabolite of albuterol in man was isolated and purified by ion-exchange chromatography and countercurrent distribution. On the basis of proton magnetic resonance, infrared, and mass-spectral analysis, enzymic hydrolysis... | [
-0.012548115104436874,
0.02532392367720604,
-0.06174944341182709,
0.01896827109158039,
0.04630255699157715,
-0.007462006527930498,
0.0292451661080122,
0.002039531012997031,
-0.007451976649463177,
-0.03411417081952095,
0.009102735668420792,
-0.05999109894037247,
-0.025849921628832817,
-0.02... |
PMID:17523 | Pharmacokinetics of intravenously injected chloramphenicol in baby pigs. | A sensitive fluorometric assay procedure for chloramphenicol and its metabolites was used to measure distribution in tissues and elimination of the drug after injection of 22 mg/kg iv in baby pigs. Disappearance of chloramphenicol from plasma was biphasic; an initial component was rapid (half-life about 9 min) and a se... | Pharmacokinetics of intravenously injected chloramphenicol in baby pigs. A sensitive fluorometric assay procedure for chloramphenicol and its metabolites was used to measure distribution in tissues and elimination of the drug after injection of 22 mg/kg iv in baby pigs. Disappearance of chloramphenicol from plasma was ... | [
-0.018259482458233833,
-0.0016593491891399026,
-0.008941764011979103,
-0.027745068073272705,
0.03971336409449577,
0.03586076572537422,
0.020683106034994125,
0.04914123937487602,
-0.03923283517360687,
-0.00475210091099143,
0.022811010479927063,
-0.06110570952296257,
0.0004067686677444726,
0... |
PMID:17524 | Biotransformation of cannabidiol in mice. Identification of new acid metabolites. | The in vivo metabolism of cannabidiol (CBD) was investigated in mice. Following the ip administration of CBD to mice, livers were removed and metabolites were extracted with ethyl acetate prior to partial purification on Sephadex LH-20 columns. Fractions from the columns were converted into trimethylsilyl, d9-trimethyl... | Biotransformation of cannabidiol in mice. Identification of new acid metabolites. The in vivo metabolism of cannabidiol (CBD) was investigated in mice. Following the ip administration of CBD to mice, livers were removed and metabolites were extracted with ethyl acetate prior to partial purification on Sephadex LH-20 co... | [
-0.023526182398200035,
-0.0545763224363327,
-0.023081902414560318,
-0.029084285721182823,
0.0836695060133934,
-0.008927591145038605,
0.025705726817250252,
0.021622225642204285,
-0.03650118410587311,
0.04622279480099678,
0.036528002470731735,
-0.06564272195100784,
0.00034166121622547507,
-0... |
PMID:17521 | Absorption, excretion and disposition of cyclindole in laboratory animals and human volunteers. | Radioactivity from orally administered single doses of cyclindole-14C was excreted primarily in the urine of the rat (99%/48 hr), monkey (80%/120 hr), and dog (70%/144 hr). Approximately 38-58% of a daily dose of cyclindole was recovered from 24-hr human urine, as determined by gas chromatography. Substantial amounts o... | Absorption, excretion and disposition of cyclindole in laboratory animals and human volunteers. Radioactivity from orally administered single doses of cyclindole-14C was excreted primarily in the urine of the rat (99%/48 hr), monkey (80%/120 hr), and dog (70%/144 hr). Approximately 38-58% of a daily dose of cyclindole ... | [
-0.038574717938899994,
-0.001866165897808969,
0.0046911658719182014,
-0.0027341973036527634,
0.04972550645470619,
-0.03432884067296982,
0.029277928173542023,
0.01716550812125206,
-0.03785279765725136,
-0.0030297022312879562,
0.059162601828575134,
-0.04219522327184677,
0.02588658779859543,
... |
PMID:17525 | The effects of delta9-tetrahydrocannabinol and cannabidiol on the metabolism of gonadal steroids in the rat. | The effects of delta9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on hydroxylation of estradiol and testosterone in rat liver microsomes were investigated. Acute and chronic treatment of male and female rats with either cannabinoid, 2 or 10 mg/kg, significantly elevated steroid hydroxylase activity. Acute administ... | The effects of delta9-tetrahydrocannabinol and cannabidiol on the metabolism of gonadal steroids in the rat. The effects of delta9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on hydroxylation of estradiol and testosterone in rat liver microsomes were investigated. Acute and chronic treatment of male and female rat... | [
-0.002692542504519224,
-0.0009133493877016008,
-0.03314267843961716,
-0.00697802659124136,
0.045721858739852905,
0.010046640411019325,
0.053665176033973694,
-0.028408925980329514,
-0.031048713251948357,
-0.004717167001217604,
0.012105870991945267,
-0.05244537442922592,
0.052898865193128586,
... |
PMID:17527 | Glucuronidation and deglucuronidation reactions in hepatic and extrahepatic tissues during perinatal development. | The relative activities of uridine diphosphoglucuronyltransferase (UDPGT) and beta-glucuronidase (betaG) were measured during perinatal development of hepatic and extrahepatic tissues to determine the balance between glucuronidation and deglucuronidation reactions at different developmental stages. Liver, lung, kidney,... | Glucuronidation and deglucuronidation reactions in hepatic and extrahepatic tissues during perinatal development. The relative activities of uridine diphosphoglucuronyltransferase (UDPGT) and beta-glucuronidase (betaG) were measured during perinatal development of hepatic and extrahepatic tissues to determine the balan... | [
-0.012197955511510372,
-0.015800716355443,
0.01196460984647274,
0.0029748559463769197,
0.03141051530838013,
0.03335094451904297,
0.0025121928192675114,
0.04647521302103996,
-0.04040250554680824,
-0.04506027325987816,
0.009880328550934792,
-0.06255283206701279,
-0.012620831839740276,
0.0251... |
PMID:17529 | Metabolism of 7,12-dimethylbenz[a]anthracene in mouse skin homogenates analyzed with high-pressure liquid chromatography. | The metabolism of 7,12-dimethylbenz[a]anthracene (DMBA) in epidermal homogenates from 3-methylcholanthrene-pretreated mice was analyzed with high-pressure liquid chromatography. Metabolism was undetectable in the absence of pretreatment. Specific activities in epidermal homogenates from pretreated mice were found to be... | Metabolism of 7,12-dimethylbenz[a]anthracene in mouse skin homogenates analyzed with high-pressure liquid chromatography. The metabolism of 7,12-dimethylbenz[a]anthracene (DMBA) in epidermal homogenates from 3-methylcholanthrene-pretreated mice was analyzed with high-pressure liquid chromatography. Metabolism was undet... | [
-0.046345651149749756,
-0.004896712955087423,
-0.0077727679163217545,
0.027095379307866096,
0.058367520570755005,
-0.00785765890032053,
-0.012728163041174412,
-0.007704426068812609,
-0.05746165290474892,
-0.04974976181983948,
0.01701076328754425,
-0.09914615750312805,
-0.05311588943004608,
... |
PMID:17534 | [Splenic infarcts in Goodpasture's syndrome: its significance for diagnosis, prognosis, and treatment (author's transl)]. | Necrotising splenic arteritis with numerous extensive anaemic splenic infarcts was found in four cases of Goodpasture's syndrome with the necrotising variant of rapidly progressive glomerulonephritis. The disease was rapidly fatal. Early scanning of splenic infarcts for diagnostic, prognostic and therapeutic purposes o... | [Splenic infarcts in Goodpasture's syndrome: its significance for diagnosis, prognosis, and treatment (author's transl)]. Necrotising splenic arteritis with numerous extensive anaemic splenic infarcts was found in four cases of Goodpasture's syndrome with the necrotising variant of rapidly progressive glomerulonephriti... | [
-0.05101067200303078,
-0.008019707165658474,
0.01184537261724472,
0.00755411246791482,
0.011240922845900059,
-0.02443709410727024,
0.08897865563631058,
0.06169430911540985,
-0.003385988064110279,
0.01182167325168848,
-0.0014794165035709739,
-0.06662952899932861,
-0.01074219774454832,
0.009... |
PMID:17531 | Microsomal N-hydroxylation of trans-4'-halo-4-acetamidostilbenes. | Hamster liver microsomes catalyze the N-hydroxylation of trans-4-acetamidostilbene and its 4'-Cl and 4'-F analogs. Other metabolites which were detected and quantitated were the 4'-OH derivative of trans-4-acetamidostilbene and the glycolamides of the 4'-Cl and 4'-F compounds. The kinetics of metabolism of the acetamid... | Microsomal N-hydroxylation of trans-4'-halo-4-acetamidostilbenes. Hamster liver microsomes catalyze the N-hydroxylation of trans-4-acetamidostilbene and its 4'-Cl and 4'-F analogs. Other metabolites which were detected and quantitated were the 4'-OH derivative of trans-4-acetamidostilbene and the glycolamides of the 4'... | [
-0.03772545978426933,
-0.005448452662676573,
-0.05092892795801163,
-0.010069208219647408,
0.0389653779566288,
0.04701725021004677,
0.0008471503388136625,
-0.0285184346139431,
-0.060308102518320084,
-0.006922044791281223,
0.053177930414676666,
-0.03491656109690666,
0.022734247148036957,
-0.... |
PMID:17536 | [Stimulation of H+ secretion and serum gastrin by intra-operative electrical vagal stimulation before and after proximal selective vagotomy (author's transl)]. | H+ secretion and gastrin concentration were measured before and after electric vagal stimulation during proximal selective vagotomy in 29 patients with duodenal ulcers. Before vagotomy, H+ secretion and serum gastrin concentration significantly rose after stimulation, while after complete vagotomy H+ secretion remained... | [Stimulation of H+ secretion and serum gastrin by intra-operative electrical vagal stimulation before and after proximal selective vagotomy (author's transl)]. H+ secretion and gastrin concentration were measured before and after electric vagal stimulation during proximal selective vagotomy in 29 patients with duodenal... | [
0.0025679010432213545,
0.029703237116336823,
0.014113414101302624,
0.006763532757759094,
0.003660654416307807,
0.04627576842904091,
0.030989138409495354,
0.05144471675157547,
0.002582476707175374,
-0.05613836273550987,
-0.05660204216837883,
-0.05382855609059334,
-0.012756711803376675,
0.05... |
PMID:17537 | Hepatic enzymes, their induction and usefulness in predicting maximal serum bilirubin levels in premature newborn infants. | Sixty-seven babies were utilized to (a) document the serum bilirubin lowering effect and safety of a phenobarbitone and nikethamide combination in neonatal hyperbilirubinaemia of non-hemolytic origin; (b) determine whether birthweight and/or SGOT, SGPT or SGGT activity on day one of life correlated with the maximum ser... | Hepatic enzymes, their induction and usefulness in predicting maximal serum bilirubin levels in premature newborn infants. Sixty-seven babies were utilized to (a) document the serum bilirubin lowering effect and safety of a phenobarbitone and nikethamide combination in neonatal hyperbilirubinaemia of non-hemolytic orig... | [
-0.019240420311689377,
-0.002901565283536911,
0.012861856259405613,
0.011056437157094479,
0.009465526789426804,
0.007056043483316898,
0.04413340985774994,
0.05850541591644287,
-0.01631617546081543,
-0.0007913997396826744,
0.011698569171130657,
-0.051321353763341904,
0.008237829431891441,
0... |
PMID:17538 | In vitro pharmacology of the opioid peptides, enkephalins and endorphins. | In the guinea-pig ileum methionine-enkephalin, normorphine and morphine are equipotent in depressing electrically evoked contractions; leucine-enkephalin has about 25% of the activity. The mouse vas deferens is more sensitive to the enkephalins which are 30 to 60 times more potent than morphine. Fragments of beta-lipot... | In vitro pharmacology of the opioid peptides, enkephalins and endorphins. In the guinea-pig ileum methionine-enkephalin, normorphine and morphine are equipotent in depressing electrically evoked contractions; leucine-enkephalin has about 25% of the activity. The mouse vas deferens is more sensitive to the enkephalins w... | [
-0.031085483729839325,
-0.03149539977312088,
-0.014882260002195835,
0.0018143273191526532,
0.02407044917345047,
0.04868870973587036,
0.052053917199373245,
0.041119400411844254,
0.00948308128863573,
-0.01219103205949068,
-0.044355060905218124,
-0.026876701042056084,
0.05450579524040222,
0.0... |
PMID:17541 | The role of adrenoceptors in norepinephrine-stimulated VO2 in muscle. | The purpose of this study was to characterize the norepinephrine (NE)-evoked calorigenic response of an isolated perfused rat muscle preparation into alpha-and/or beta-adrenergic components. Epinephrine was as effective as NE in evoking the increase in oxygen consumption. The alpha-agonist, phenylephrine, was also as e... | The role of adrenoceptors in norepinephrine-stimulated VO2 in muscle. The purpose of this study was to characterize the norepinephrine (NE)-evoked calorigenic response of an isolated perfused rat muscle preparation into alpha-and/or beta-adrenergic components. Epinephrine was as effective as NE in evoking the increase ... | [
-0.054842427372932434,
-0.003344248980283737,
0.011527737602591515,
0.0407397635281086,
0.03786417469382286,
-0.015911772847175598,
0.0533062107861042,
0.06043604388833046,
-0.0254793893545866,
-0.0578787699341774,
0.026811260730028152,
-0.03431444615125656,
-0.05358413979411125,
0.0915903... |
PMID:17544 | [Effect of a schedule of administration of chlorpromazine, majeptil and trisedyl on the synthesis of proteins in different brain structures of rats]. | Following a course-wise introduction of chlorpromazine, majeptil and trisedyl to rats the methionine-35S incorporation in the protein was diminished in most of the brain segments. | [Effect of a schedule of administration of chlorpromazine, majeptil and trisedyl on the synthesis of proteins in different brain structures of rats]. Following a course-wise introduction of chlorpromazine, majeptil and trisedyl to rats the methionine-35S incorporation in the protein was diminished in most of the brain ... | [
-0.051092710345983505,
-0.013504485599696636,
0.0288115032017231,
0.013105686753988266,
0.012721228413283825,
0.033998776227235794,
0.04391428083181381,
0.041073162108659744,
-0.06485918909311295,
-0.016140425577759743,
0.014762521721422672,
-0.02468097023665905,
0.04247104004025459,
0.037... |
PMID:17545 | [Effect of nonachlazine on the processes of uptake and release of nordrenaline]. | Nonachlazine (2 micrometer) blocked significantly the uptake 1 of endogenic noradrenaline in the myocardial tissues and in adrenergic neurons of vas deferens. The uptake II, as well as the intensity and dynamics of the noradrenaline release were not affected by nonachlazine. These processes resulted in an increase of f... | [Effect of nonachlazine on the processes of uptake and release of nordrenaline]. Nonachlazine (2 micrometer) blocked significantly the uptake 1 of endogenic noradrenaline in the myocardial tissues and in adrenergic neurons of vas deferens. The uptake II, as well as the intensity and dynamics of the noradrenaline releas... | [
-0.036925312131643295,
0.002124892082065344,
-0.02421492338180542,
0.03805474936962128,
0.021834956482052803,
-0.038680240511894226,
0.05791270732879639,
0.0019024042412638664,
-0.023421697318553925,
-0.09432841837406158,
0.03697066754102707,
-0.026247099041938782,
0.033441077917814255,
0.... |
PMID:17547 | [Stabilization of biological membranes with various acetylene amines]. | In experiments with mitochondrial membranes and membranes of the endoplasmatic reticulum of the rats' liver the membrane-stabilizing action of a number of unsaturated amines was evaluated. The acetylene compounds studied reduced the extent of the membranes damage following UV-irradiation, treatment with detergents and ... | [Stabilization of biological membranes with various acetylene amines]. In experiments with mitochondrial membranes and membranes of the endoplasmatic reticulum of the rats' liver the membrane-stabilizing action of a number of unsaturated amines was evaluated. The acetylene compounds studied reduced the extent of the me... | [
-0.03855849802494049,
-0.007866966538131237,
-0.018831642344594002,
0.016473546624183655,
0.03293929994106293,
-0.01159847341477871,
0.00031139369821175933,
-0.02522851899266243,
-0.0657043308019638,
-0.04672146216034889,
0.013328982517123222,
-0.05844553932547569,
0.005283712409436703,
0.... |
PMID:17546 | [Study of the induction of thrombocyte adhesiveness in the presence of heparin]. | An investigation of the thrombocytes adhesion after Hellem (1960) showed that "in vitro" tests norepinephrine, epinephrine, histamine, serotonin and adenosine-diphosphate, when used in doses of 100-25,0 gamma/ml, were capable of raising the thrombocytes adhesion, while heparin administered in doses of 0.5-0.05 U/ml dep... | [Study of the induction of thrombocyte adhesiveness in the presence of heparin]. An investigation of the thrombocytes adhesion after Hellem (1960) showed that "in vitro" tests norepinephrine, epinephrine, histamine, serotonin and adenosine-diphosphate, when used in doses of 100-25,0 gamma/ml, were capable of raising th... | [
-0.06764622777700424,
-0.003073696047067642,
-0.0007013783906586468,
0.008199334144592285,
-0.01774008758366108,
0.05202029272913933,
0.08043130487203598,
0.058021292090415955,
-0.054630156606435776,
-0.051078468561172485,
-0.03832114487886429,
-0.0366743728518486,
-0.04448584467172623,
0.... |
PMID:17557 | A double-blind trial of penbutolol: a new beta-receptor blocking agent in the treatment of angina pectoris. | A double-blind placebo controlled study of angina pectoris with penbutolol was undertaken in parallel groups in fifty-two patients. The duration of the study was six weeks. The dosage range for penbutolol was 8 mg to 50 mg per day. Six patients were dropped from the analysis. Seventeen patients (81%) in the penbutolol ... | A double-blind trial of penbutolol: a new beta-receptor blocking agent in the treatment of angina pectoris. A double-blind placebo controlled study of angina pectoris with penbutolol was undertaken in parallel groups in fifty-two patients. The duration of the study was six weeks. The dosage range for penbutolol was 8 m... | [
-0.038174670189619064,
-0.004026941489428282,
-0.01786692626774311,
0.022399617359042168,
0.03208549693226814,
0.00413149781525135,
0.011944864876568317,
0.0061162603087723255,
-0.04020179063081741,
-0.05524221062660217,
-0.02985050156712532,
-0.06810487061738968,
0.00794578529894352,
0.04... |
PMID:17558 | A trial of benorylate tablets in the symptomatic relief of osteoarthritis. | The effectiveness of Benoral Tablets in controlling joint pain and stiffness in osteoarthritis was assessed over a two-week period in a multicentre general practice open study. In this trial it has been demonstrated that a correlation exists between pain relief from stiffness for patients suffering from osteoarthritis ... | A trial of benorylate tablets in the symptomatic relief of osteoarthritis. The effectiveness of Benoral Tablets in controlling joint pain and stiffness in osteoarthritis was assessed over a two-week period in a multicentre general practice open study. In this trial it has been demonstrated that a correlation exists bet... | [
-0.006399592384696007,
-0.029200799763202667,
0.03379159793257713,
-0.02140090987086296,
-0.010509982705116272,
-0.003725562710314989,
-0.009722295217216015,
0.07684851437807083,
-0.06257987767457962,
-0.04937702417373657,
-0.0015865231398493052,
-0.025647912174463272,
0.02323787659406662,
... |
PMID:17559 | Polygraphic sleep recordings before and after the administration of flunitrazepam. | By means of polygraphic sleep recordings (EEG, EOG, EMG, ECG, EDG, Respirogram, Positogram), neurologic-psychologic investigation and questionnaires on subjective feeling, ten patients aged from 22 to 40 years (mean: 29 years), who suffered from irregular disturbances in falling asleep and in sleeping continuously, wer... | Polygraphic sleep recordings before and after the administration of flunitrazepam. By means of polygraphic sleep recordings (EEG, EOG, EMG, ECG, EDG, Respirogram, Positogram), neurologic-psychologic investigation and questionnaires on subjective feeling, ten patients aged from 22 to 40 years (mean: 29 years), who suffe... | [
0.009390044026076794,
0.04000863805413246,
0.02136566862463951,
0.04913884773850441,
0.020703254267573357,
0.09222965687513351,
0.02078280784189701,
0.002956382231786847,
0.017152288928627968,
-0.041438743472099304,
-0.012462176382541656,
0.011855199001729488,
0.013109173625707626,
-0.0119... |
PMID:17563 | Effect of secretin on plasma motilin in man. | Graded doses of 0-1, 0-3, 0-9, and 2-7 clinical units/kg/h of pure synthetic secretin were infused over 60 minute periods in six healthy volunteers. Duodenal bicarbonate output and pH were recorded and plasma secretin and motilin levels were measured by radioimmunoassay. During the infusions plasma motilin fell in a do... | Effect of secretin on plasma motilin in man. Graded doses of 0-1, 0-3, 0-9, and 2-7 clinical units/kg/h of pure synthetic secretin were infused over 60 minute periods in six healthy volunteers. Duodenal bicarbonate output and pH were recorded and plasma secretin and motilin levels were measured by radioimmunoassay. Dur... | [
-0.04310224950313568,
0.042084045708179474,
0.008795774541795254,
0.006850884296000004,
-0.009155933745205402,
-0.03132836893200874,
0.06637106835842133,
0.03537440672516823,
-0.042377226054668427,
-0.04043211042881012,
-0.019874125719070435,
-0.08663592487573624,
0.043243493884801865,
0.0... |
PMID:17564 | Jejunal mucosal gamma glutamyl transferase activity in coeliac disease. | In view of data suggesting that deficiency of gamma glutamyl transferase (GGT) may be the primary abnormality in the small-intestinal mucosa of patients with coeliac disease, this enzyme was measured in mucosal biopsies from coeliac patients at different stages of treatment. Activity was only slightly reduced in only o... | Jejunal mucosal gamma glutamyl transferase activity in coeliac disease. In view of data suggesting that deficiency of gamma glutamyl transferase (GGT) may be the primary abnormality in the small-intestinal mucosa of patients with coeliac disease, this enzyme was measured in mucosal biopsies from coeliac patients at dif... | [
0.05317427217960358,
-0.020906291902065277,
0.012483837082982063,
0.02030530758202076,
-0.01557030901312828,
-0.03159506991505623,
0.04283347725868225,
0.06415526568889618,
-0.05900411680340767,
-0.05892464518547058,
0.0031288352329283953,
-0.1066448763012886,
-0.0016454184660688043,
0.034... |
PMID:17565 | Correlation between manometric and pH tests for gastro-oesophageal reflux. | A series of tests, including gastro-oesophageal sphincter pressure measurement, short-term pH tests, and 15-hour overnight oesophageal pH recording were applied to 42 normal subjects and 214 patients with typical reflux symptoms. The results were compared by multivariate discriminant analysis. Sphincter pressure measur... | Correlation between manometric and pH tests for gastro-oesophageal reflux. A series of tests, including gastro-oesophageal sphincter pressure measurement, short-term pH tests, and 15-hour overnight oesophageal pH recording were applied to 42 normal subjects and 214 patients with typical reflux symptoms. The results wer... | [
0.04117569699883461,
0.013063972815871239,
0.01861867867410183,
0.02596287615597248,
0.023181207478046417,
-0.0639035552740097,
0.07288951426744461,
0.03738626837730408,
-0.031607214361429214,
-0.08722542226314545,
-0.029822250828146935,
-0.09976647049188614,
-0.016788331791758537,
0.05079... |
PMID:17567 | [Utilization of the MVA-immunization schedule from the view point of the public health service]. | The world-wide smallpox eradication program sponsored by the WHO has been successful. Furthermore the legislation regarding smallpox vaccination in the Federal Republic of Germany has been given a new form. The place of the previous mass-vaccination has been taken by vaccination of individuals. Under this aspect safe p... | [Utilization of the MVA-immunization schedule from the view point of the public health service]. The world-wide smallpox eradication program sponsored by the WHO has been successful. Furthermore the legislation regarding smallpox vaccination in the Federal Republic of Germany has been given a new form. The place of the... | [
-0.0024984292685985565,
0.04149240627884865,
-0.016009388491511345,
-0.045228272676467896,
0.019758010283112526,
-0.03308209031820297,
0.04752739891409874,
0.04078138247132301,
-0.05253123119473457,
0.0014229754451662302,
-0.004439539276063442,
-0.09347762167453766,
0.001749460119754076,
-... |
PMID:17572 | Characteristics of the maternal lymphoid response of mice to paternal strain antigens induced by homologous pregnancy. | Mice mated with H-2 incompatible males were shown to have an increased frequency of specific allocluster-forming spleen cells to paternal strain erythrocytes. The time course of the response was similar to that expected following a skin allograft. The graft-versus-host responsiveness of the maternal lymphocytes was gen... | Characteristics of the maternal lymphoid response of mice to paternal strain antigens induced by homologous pregnancy. Mice mated with H-2 incompatible males were shown to have an increased frequency of specific allocluster-forming spleen cells to paternal strain erythrocytes. The time course of the response was simila... | [
-0.034306395798921585,
0.042802002280950546,
-0.07429365813732147,
-0.0023526609875261784,
-0.006048678420484066,
0.007380133494734764,
0.08372212946414948,
0.09346460551023483,
-0.039718713611364365,
-0.02246960438787937,
-0.031019670888781548,
-0.05166950449347496,
-0.01696491427719593,
... |
PMID:17574 | Identification, separation, and preliminary characterization of invertase and beta-galactosidase in Actinomyces viscosus. | The initial step of disaccharide dissimilation by Actinomyces viscosus serotype 2 strain M-100 was studied. Sucrase activity was found in the 3,000 X g particulate fraction and the 37,000 X g soluble fraction of the cells, whereas lactase activity was found almost exclusively in the 37,000 X g soluble fraction. Neither... | Identification, separation, and preliminary characterization of invertase and beta-galactosidase in Actinomyces viscosus. The initial step of disaccharide dissimilation by Actinomyces viscosus serotype 2 strain M-100 was studied. Sucrase activity was found in the 3,000 X g particulate fraction and the 37,000 X g solubl... | [
-0.0677369087934494,
-0.08955584466457367,
-0.028643488883972168,
0.011312785558402538,
0.023932205513119698,
-0.05791757255792618,
0.014361061155796051,
0.03527835011482239,
-0.02265159599483013,
0.0008107941830530763,
0.003446900052949786,
-0.11009865999221802,
-0.03739714249968529,
-0.0... |
PMID:17576 | Corneal transplantation reaction in avascular keratoconus patients due to HLA-associated immune aberration against infection. A hypothesis. | HLA-B12 and HLA-B27 appeared to be characteristic of avascular keratoconus patients at risk of developing a corneal allograft reaction, which was mainly of late type and triggered by a nasopharyngeal infection. Equally incompatible grafts to patients with HLA-B5 had an uneventful course. This may be inference to the ro... | Corneal transplantation reaction in avascular keratoconus patients due to HLA-associated immune aberration against infection. A hypothesis. HLA-B12 and HLA-B27 appeared to be characteristic of avascular keratoconus patients at risk of developing a corneal allograft reaction, which was mainly of late type and triggered ... | [
-0.0351293571293354,
0.06316773593425751,
-0.03282700106501579,
0.04717449098825455,
-0.0006493090186268091,
-0.0017771031707525253,
0.08866635710000992,
0.07925533503293991,
-0.07291711121797562,
0.005943199619650841,
0.02113739773631096,
-0.10631989687681198,
-0.05479808151721954,
-0.049... |
PMID:17578 | Hepatic microsomal enzyme induction and its evaluation in a clinical laboratory. | We tried to determine whether short-term treatment with alpha-methyldopa, quinidine, digoxin, diazepam or furosemide--drugs in common use in hospitals--is capable of stimulating the activity of hepatic microsomal drug-metabolizing enzymes. Glucaric acid (GA) excretion and serum activity of gamma-glutamyl transpeptidase... | Hepatic microsomal enzyme induction and its evaluation in a clinical laboratory. We tried to determine whether short-term treatment with alpha-methyldopa, quinidine, digoxin, diazepam or furosemide--drugs in common use in hospitals--is capable of stimulating the activity of hepatic microsomal drug-metabolizing enzymes.... | [
0.009974275715649128,
0.017090637236833572,
0.06332922726869583,
0.02608688548207283,
-0.004902762360870838,
-0.008249541744589806,
0.013577146455645561,
0.040620528161525726,
-0.029917914420366287,
-0.054320331662893295,
-0.03315473347902298,
-0.02033902332186699,
-0.013293690979480743,
0... |
PMID:17573 | The interaction of barbiturates and analeptics. | The interaction of pentobarbitone sodium with three analeptics viz. micoren, pentylenetetrazol and methedrine was studied in mice. Micoren prolonged pentobarbitone sleeping time. pentylenetetrazol shortened the sleeping time. Methedrine also shortened the sleeping time, but clonic convulsions of mild to severe intensit... | The interaction of barbiturates and analeptics. The interaction of pentobarbitone sodium with three analeptics viz. micoren, pentylenetetrazol and methedrine was studied in mice. Micoren prolonged pentobarbitone sleeping time. pentylenetetrazol shortened the sleeping time. Methedrine also shortened the sleeping time, b... | [
-0.09198517352342606,
0.033579979091882706,
-0.01202924083918333,
0.015258140861988068,
0.0034929129760712385,
0.02109876275062561,
0.08357398211956024,
-0.008933824487030506,
-0.04533998668193817,
-0.08313513547182083,
-0.055888719856739044,
-0.0002636275894474238,
-0.01461124885827303,
0... |
PMID:17579 | [Unusually high gamma-glutamyltransferase level in the semen and ist diagnostic significance]. | A remarkable high activity of the enzyme gamma-glutamyltransferase (gamma-GT) is found in seminal fluid in 200 to 500 fold higher concentrations as found in blood serum. The seminal fluid gamma-GT originates expecially in the prostate gland and, to a smaller extent, in spermatozoa and secretion of testis and epididymis... | [Unusually high gamma-glutamyltransferase level in the semen and ist diagnostic significance]. A remarkable high activity of the enzyme gamma-glutamyltransferase (gamma-GT) is found in seminal fluid in 200 to 500 fold higher concentrations as found in blood serum. The seminal fluid gamma-GT originates expecially in the... | [
0.0396917499601841,
0.014074528589844704,
0.0012197813484817743,
-0.0424855537712574,
0.010828462429344654,
0.016183335334062576,
0.06926096230745316,
0.07341893762350082,
-0.01012455951422453,
-0.04528268054127693,
0.014106468297541142,
-0.07688388228416443,
-0.011398001573979855,
0.06175... |
PMID:17575 | Aids for in vitro Mycobacterium lepraemurium investigations: estimation of oxidation-reduction potentials and pO2 with 2, 6 dichlorophenol indophenol. | The partial success in cultivating a "host-dependent" microbe provided the incentive to develop methods which may aid the growth of the organism. The oxidation-reduction potential (ORP) of NC-5, an aerobic, cysteine containing medium which supports the limited in vitro growth of Mycobacterium lepraemurium, is measurabl... | Aids for in vitro Mycobacterium lepraemurium investigations: estimation of oxidation-reduction potentials and pO2 with 2, 6 dichlorophenol indophenol. The partial success in cultivating a "host-dependent" microbe provided the incentive to develop methods which may aid the growth of the organism. The oxidation-reduction... | [
-0.06975383311510086,
0.02752816304564476,
-0.02028658241033554,
-0.009441344998776913,
0.0545579269528389,
-0.05020229518413544,
0.020375562831759453,
0.0666176974773407,
-0.06631075590848923,
-0.010020311921834946,
0.06887821108102798,
-0.04322763904929161,
0.006790048908442259,
-0.01926... |
PMID:17580 | [Microchemical investigation of alpha D-glucosidases using 4-methylumnelliferyl- and 2-naphthyl-alpha-d-glucoside (author's transl)]. | In crude homogenates prepared from freeze-dried cryostate sections of various rat organs the Km and Vmax of acid and neutral alpha-glucosidase as well as the effect of the pH, substrate and enzyme concentration and the incubation time on the activity were determined fluorometrically with 4-methylumbelliferyl- and 2-nap... | [Microchemical investigation of alpha D-glucosidases using 4-methylumnelliferyl- and 2-naphthyl-alpha-d-glucoside (author's transl)]. In crude homogenates prepared from freeze-dried cryostate sections of various rat organs the Km and Vmax of acid and neutral alpha-glucosidase as well as the effect of the pH, substrate ... | [
-0.01768656261265278,
0.001992101315408945,
-0.03704686462879181,
0.014264960773289204,
0.042092423886060715,
0.0006645688554272056,
0.019938213750720024,
0.06531161814928055,
-0.017172234132885933,
-0.06683418899774551,
0.017148831859230995,
-0.07007593661546707,
-0.02084818109869957,
-0.... |
PMID:17585 | Nursing education in crisis: a computer alternative. | The impact of computer-assisted instruction upon the educational process is having its effect. The computer is being used in nursing education today to manage the educational environment, to instruct, to evaluate, to identify problem areas, to gather data, to manipulate data for research purposes and for continued educ... | Nursing education in crisis: a computer alternative. The impact of computer-assisted instruction upon the educational process is having its effect. The computer is being used in nursing education today to manage the educational environment, to instruct, to evaluate, to identify problem areas, to gather data, to manipul... | [
-0.03593386709690094,
-0.023710010573267937,
0.040418148040771484,
-0.03553318977355957,
0.020952722057700157,
0.018449770286679268,
-0.012755239382386208,
0.027056848630309105,
-0.005137742031365633,
-0.029324620962142944,
0.011769085191190243,
0.019796570762991905,
-0.001562574994750321,
... |
PMID:17589 | Using the computer to prepare multiple-choice examinations: a simplified system. | Program TEST offers a quick, easy, and efficient way to produce objectively-scored exams from an established item bank. It is especially useful in situations where frequent testing is utilized and secretarial help is scarce. The capability of constructing a customized exam the day before its administration should make ... | Using the computer to prepare multiple-choice examinations: a simplified system. Program TEST offers a quick, easy, and efficient way to produce objectively-scored exams from an established item bank. It is especially useful in situations where frequent testing is utilized and secretarial help is scarce. The capability... | [
-0.04612758010625839,
0.05960329622030258,
-0.006392645183950663,
-0.021706804633140564,
-0.014238772913813591,
-0.012575581669807434,
0.030431561172008514,
0.032802242785692215,
-0.03367215022444725,
-0.028648242354393005,
-0.041194576770067215,
-0.004008995369076729,
0.030329352244734764,
... |
PMID:17593 | Itaconate, an isocitrate lyase-directed inhibitor in Pseudomonas indigofera. | Enzymes catalyzing steps from ethanol to acetyl-coenzyme A, from malate to pyruvate, and from pyruvate to glucose 6-phosphate were identified in ethanol-grown Pseudomonas indigofera. Enzymes catalyzing the catabolism of glucose to pyruvate via the Entner-Doudoroff pathway were identified in glucose-grown cells. Phospho... | Itaconate, an isocitrate lyase-directed inhibitor in Pseudomonas indigofera. Enzymes catalyzing steps from ethanol to acetyl-coenzyme A, from malate to pyruvate, and from pyruvate to glucose 6-phosphate were identified in ethanol-grown Pseudomonas indigofera. Enzymes catalyzing the catabolism of glucose to pyruvate via... | [
-0.03674396127462387,
-0.0071206060238182545,
-0.04937994107604027,
0.018771443516016006,
0.036696042865514755,
-0.021813053637742996,
-0.002351367147639394,
0.0638875886797905,
-0.10236486792564392,
-0.03226974979043007,
0.10660696029663086,
-0.07402607053518295,
-0.0016264611622318625,
0... |
PMID:17594 | Chemotaxis toward amino acids by Bdellovibrio bacteriovorus. | Chemotaxis toward amino acids by Bdellovibrio bacteriovorous strain UKi2 was studied by the capillary technique of Adler (J. Gen. Microbiol. 74:77-91, 1973). Chemotaxis was shown to be optimal when the capillaries were incubated at between 15 and 40 degrees C for 30 min; the optimal pH was between 7.0 and 8.2. The chem... | Chemotaxis toward amino acids by Bdellovibrio bacteriovorus. Chemotaxis toward amino acids by Bdellovibrio bacteriovorous strain UKi2 was studied by the capillary technique of Adler (J. Gen. Microbiol. 74:77-91, 1973). Chemotaxis was shown to be optimal when the capillaries were incubated at between 15 and 40 degrees C... | [
-0.04535884037613869,
0.0022437451407313347,
-0.03765181824564934,
-0.009092971682548523,
0.036890577524900436,
-0.054908011108636856,
0.03624739870429039,
0.021751994267106056,
-0.03472401201725006,
-0.019924378022551537,
0.016225432977080345,
-0.08573875576257706,
0.033972129225730896,
0... |
PMID:17595 | Fructose 1,6-diphosphate-activated L-lactate dehydrogenase from Streptococcus lactis: kinetic properties and factors affecting activation. | The L-(+)-lactate dehydrogenase (L-lactate:NAD+ oxidoreductase, EC 1.1.1.27) of Streptococcus lactis C10, like that of other streptococci, was activated by fructose 1,6-diphosphate (FDP). The enzyme showed some activity in the absence of FDP, with a pH optimum of 8.2; FDP decreased the Km for both pyruvate and reduced ... | Fructose 1,6-diphosphate-activated L-lactate dehydrogenase from Streptococcus lactis: kinetic properties and factors affecting activation. The L-(+)-lactate dehydrogenase (L-lactate:NAD+ oxidoreductase, EC 1.1.1.27) of Streptococcus lactis C10, like that of other streptococci, was activated by fructose 1,6-diphosphate ... | [
-0.04520076885819435,
-0.03193218261003494,
0.004076017532497644,
0.02514384686946869,
0.023481305688619614,
-0.014189978130161762,
0.02209005132317543,
0.09809231013059616,
-0.04802893102169037,
-0.03449574485421181,
0.04213586822152138,
-0.0738377794623375,
-0.015525724738836288,
-0.0071... |
PMID:17596 | On the apparent inhibition of intramolecular activation of pepsinogen by pepsin substrates. | Marciniszyn et al. (Marciniszyn, J., Huang, J. S. Hartsuch, J. A., Tang, J. (1976) J. Biol. Chem. 251, 7095-7102) have recently suggested an intermediate in the intramolecular activation of pepsinogen. As evidence, they showed apparent competitive inhibition of activation by globin, indication a pepsinogen-globin compl... | On the apparent inhibition of intramolecular activation of pepsinogen by pepsin substrates. Marciniszyn et al. (Marciniszyn, J., Huang, J. S. Hartsuch, J. A., Tang, J. (1976) J. Biol. Chem. 251, 7095-7102) have recently suggested an intermediate in the intramolecular activation of pepsinogen. As evidence, they showed a... | [
-0.04681644216179848,
0.003353054402396083,
-0.03998463600873947,
0.030103567987680435,
0.02614218182861805,
-0.0243537500500679,
0.0805797129869461,
0.050641823559999466,
-0.016008285805583,
-0.035759396851062775,
0.013858594931662083,
-0.05591285601258278,
0.012775554321706295,
0.0521210... |
PMID:17600 | Circular dichroic and perturbation spectra of aromatic chromophores in rabbit tropomyosin. Topography of tyrosine residues. | 1. Difference spectra of tryosyl residues obtained on denaturation of tropomycosin with urea or guanidinium chloride indicate that strong hydrophobic environments exist in the native coiled-coil state. 2. Solvent perturbation difference spectra indicate that tyrosyl residues are partially accessible to the solvent. The... | Circular dichroic and perturbation spectra of aromatic chromophores in rabbit tropomyosin. Topography of tyrosine residues. 1. Difference spectra of tryosyl residues obtained on denaturation of tropomycosin with urea or guanidinium chloride indicate that strong hydrophobic environments exist in the native coiled-coil s... | [
-0.08042535930871964,
-0.07048994302749634,
-0.0479450523853302,
0.010584788396954536,
0.00848737359046936,
0.016015976667404175,
0.04073599353432655,
0.05087810754776001,
-0.01769215241074562,
-0.026644092053174973,
0.03761771321296692,
-0.03714027628302574,
-0.013137439265847206,
0.03230... |
PMID:17605 | Purification and properties of tRNA(adenine-1)-methyltransferase from rat liver. | An S-adenosylmethionine-dependent tRNA(adenine-1)-methyltransferase has been purified 8,000-fold from rat liver. This preparation gives a single band on polyacrylamide gel electrophoresis and is stable in long term storage. The enzyme has a molecular weight of approximately 95,000. The single methylating capacity of th... | Purification and properties of tRNA(adenine-1)-methyltransferase from rat liver. An S-adenosylmethionine-dependent tRNA(adenine-1)-methyltransferase has been purified 8,000-fold from rat liver. This preparation gives a single band on polyacrylamide gel electrophoresis and is stable in long term storage. The enzyme has ... | [
-0.06159704178571701,
-0.006024591624736786,
-0.07179423421621323,
-0.024045443162322044,
-0.030535642057657242,
0.04125265032052994,
0.04424290731549263,
0.015107101760804653,
-0.031032903119921684,
0.03214927017688751,
-0.008834087289869785,
-0.07229892909526825,
0.00006772179040126503,
... |
PMID:17606 | PZ-peptidase from chick embryos. Purification, properties, and action on collagen peptides. | PZ-peptidase is an endopeptidase that cleaves the synthetic substrate developed for clostridial collagenase, 4-phenylazobenzyloxycarbonyl-L-Pro-L-Leu-Gly-L-Pro-D-Arg (PZ-peptide). The peptidase has been purified to homogeneity from chicken embryos. The enzyme has a pH optimum of 7.5 to 8.5, and isoelectric point of 5.0... | PZ-peptidase from chick embryos. Purification, properties, and action on collagen peptides. PZ-peptidase is an endopeptidase that cleaves the synthetic substrate developed for clostridial collagenase, 4-phenylazobenzyloxycarbonyl-L-Pro-L-Leu-Gly-L-Pro-D-Arg (PZ-peptide). The peptidase has been purified to homogeneity f... | [
-0.07635994255542755,
-0.026680098846554756,
-0.061440326273441315,
0.0543798990547657,
-0.0009317746735177934,
-0.014620250090956688,
0.010684581473469734,
0.04973674193024635,
-0.013904121704399586,
-0.000016744206732255407,
0.002847194904461503,
-0.09171608835458755,
-0.004684121813625097... |
PMID:17607 | Studies on cobalt myoglobins and hemoglobins. Interaction of sperm whale myoglobin and Glycera hemoglobin with molecular oxygen. | The pH dependence of the electron paramagnetic resonance (EPR) spectrum and oxygen affinity of cobaltous porphyrin-containing myoglobin (CoMb) have been examined. The hyperfine structures of the EPR spectrum of oxy-CoMb undergo small, reversible pH-dependent changes with pK values of 5.33, 5.55, and 5.25 +/- 0.05 for p... | Studies on cobalt myoglobins and hemoglobins. Interaction of sperm whale myoglobin and Glycera hemoglobin with molecular oxygen. The pH dependence of the electron paramagnetic resonance (EPR) spectrum and oxygen affinity of cobaltous porphyrin-containing myoglobin (CoMb) have been examined. The hyperfine structures of ... | [
-0.08520560711622238,
0.05321755260229111,
-0.0114253805950284,
0.03165536746382713,
-0.014866587705910206,
-0.0614827536046505,
0.08643162995576859,
-0.013981667347252369,
-0.0476609505712986,
0.008898565545678139,
0.026304148137569427,
-0.033458858728408813,
-0.013075067661702633,
0.0136... |
PMID:17608 | Lipid A mutants of Salmonella typhimurium. Purification and characterization of a lipid A precursor produced by a mutant in 3-deoxy-D-mannooctulosonate-8-phosphate synthetase. | We describe here the isolation, purification, and structural characterization of a lipid A precursor synthesized under nonpermissive conditions by a mutant of Salmonella typhimurium conditionally defective in the synthesis of the 3-deoxy-D-mannoctulosonate (2-keto-3-deoxyoctonate, KDO) region of the lipopolysaccharide.... | Lipid A mutants of Salmonella typhimurium. Purification and characterization of a lipid A precursor produced by a mutant in 3-deoxy-D-mannooctulosonate-8-phosphate synthetase. We describe here the isolation, purification, and structural characterization of a lipid A precursor synthesized under nonpermissive conditions ... | [
-0.09197117388248444,
-0.02159072831273079,
-0.003475795267149806,
-0.009284169413149357,
-0.008000505156815052,
-0.030245693400502205,
0.03661465272307396,
0.05170409753918648,
-0.065484918653965,
0.023568423464894295,
0.029483089223504066,
-0.08747797459363937,
0.010648325085639954,
-0.0... |
PMID:17609 | Role of coenzyme in aminotransferase turnover. | The role of coenzyme in determining intracellular contnet of pyridoxal enzymes was assessed by analyzing effects of pyridoxine deficiency on the rapidly degraded, readily dissociable tyrosine aminotransferase (EC 2.6.1.5) and the slowly degraded, nondissociable alanine aminotransferase (EC 2.6.1.2) of rat liver. Synthe... | Role of coenzyme in aminotransferase turnover. The role of coenzyme in determining intracellular contnet of pyridoxal enzymes was assessed by analyzing effects of pyridoxine deficiency on the rapidly degraded, readily dissociable tyrosine aminotransferase (EC 2.6.1.5) and the slowly degraded, nondissociable alanine ami... | [
-0.0352572463452816,
0.023639865219593048,
-0.046058837324380875,
0.02008293755352497,
-0.022787602618336678,
0.008475277572870255,
0.061732761561870575,
0.03531983867287636,
-0.06492465734481812,
-0.03617266193032265,
0.055577196180820465,
-0.09892909973859787,
0.051114585250616074,
0.036... |
PMID:17611 | In vitro reconstitution of demolybdosulfite oxidase by molybdate. | Reconstitution of purified demolybdosulfite oxidase from rat liver has been achieved using inorganic molybdate as the source of molybdenum. The activation process has a pH optimum of 7.4 and is dependent on concentrations of molybdate and demolybdoenzyme. The reaction is inhibited by high concentrations of anions and b... | In vitro reconstitution of demolybdosulfite oxidase by molybdate. Reconstitution of purified demolybdosulfite oxidase from rat liver has been achieved using inorganic molybdate as the source of molybdenum. The activation process has a pH optimum of 7.4 and is dependent on concentrations of molybdate and demolybdoenzyme... | [
-0.07380501925945282,
0.037656329572200775,
-0.03183140233159065,
0.026465119794011116,
-0.0019768858328461647,
-0.07007289677858353,
-0.015014558099210262,
0.015486469492316246,
-0.04451940581202507,
-0.03870978578925133,
0.0013674156507477164,
-0.0903969258069992,
-0.017221640795469284,
... |
PMID:17615 | Lacerations of the flexor hallucis longus in the young athlete. | Of ten patients with lacerations of the flexor hallucis longus tendon, nine were athletically inclined. In four, the laceration was not repaired and no disability was evident. A functioning flexor hallucis longus, therefore, does not seem to be essential for good push-off and balance in running sports. If both the flex... | Lacerations of the flexor hallucis longus in the young athlete. Of ten patients with lacerations of the flexor hallucis longus tendon, nine were athletically inclined. In four, the laceration was not repaired and no disability was evident. A functioning flexor hallucis longus, therefore, does not seem to be essential f... | [
-0.014204354025423527,
-0.050693973898887634,
0.0695958063006401,
0.0870094820857048,
0.006064354442059994,
-0.04364178702235222,
0.002837932202965021,
0.05489148944616318,
-0.03844781219959259,
-0.04692497476935387,
-0.011830714531242847,
-0.05116042494773865,
-0.03414972871541977,
-0.031... |
PMID:17616 | Effects of cytosine arabinoside on differential gene expression in embryonic neural retina. II. Immunochemical studies on the accumulation of glutamine synthetase. | Cytosine arabinoside (Ara-C) elicits a significant increase in the level of the enzyme glutamine synthetase (GS) while it markedly reduces overall RNA and protein synthesis in cultures of embryonic chick neural retina. This increase was analyzed by radioimmunochemical procedures and compared with the induction of GS by... | Effects of cytosine arabinoside on differential gene expression in embryonic neural retina. II. Immunochemical studies on the accumulation of glutamine synthetase. Cytosine arabinoside (Ara-C) elicits a significant increase in the level of the enzyme glutamine synthetase (GS) while it markedly reduces overall RNA and p... | [
-0.0001490446156822145,
0.00021298891806509346,
-0.030533961951732635,
0.0284845270216465,
0.018875736743211746,
0.046435680240392685,
0.04573908448219299,
-0.02138562686741352,
-0.03940723091363907,
0.02036074362695217,
0.02315698377788067,
-0.022015811875462532,
0.024166297167539597,
-0.... |
PMID:17618 | Modulation of in vitro erythropoiesis. The influence of beta-adrenergic agonists on erythroid colony formation. | Canine marrow erythroid colony growth is enhanced by agents linked to the adenyl cyclase/cyclic AMP (cAMP) system, including cAMP, a phosphodieterase inhibitor (RO-20-1724), cholera enterotoxin, and beta-adrenergic agonists. The adrenergic effect is mediated by receptors having beta2-subspecificity. These receptors are... | Modulation of in vitro erythropoiesis. The influence of beta-adrenergic agonists on erythroid colony formation. Canine marrow erythroid colony growth is enhanced by agents linked to the adenyl cyclase/cyclic AMP (cAMP) system, including cAMP, a phosphodieterase inhibitor (RO-20-1724), cholera enterotoxin, and beta-adre... | [
-0.04539870098233223,
0.00644901255145669,
-0.00848179217427969,
0.030485739931464195,
-0.0037845924962311983,
-0.027229154482483864,
0.0207855012267828,
0.024740872904658318,
-0.0687064453959465,
0.010538393631577492,
0.04616319015622139,
-0.036036740988492966,
-0.029723716899752617,
0.04... |
PMID:17619 | Effect of ascorbic acid on arylsulfatase activities and sulfated proteoglycan metabolism in chondrocyte cultures. | A correlation between increased arylsulfatase activities and decreased sulfated proteoglycan content in human osteoarthritic articular cartilage suggested a possible interrelationship between these parameters. Since we had previously shown that ascorbate caused a decrease in levels of arylsulfatase A and B activities i... | Effect of ascorbic acid on arylsulfatase activities and sulfated proteoglycan metabolism in chondrocyte cultures. A correlation between increased arylsulfatase activities and decreased sulfated proteoglycan content in human osteoarthritic articular cartilage suggested a possible interrelationship between these paramete... | [
-0.041604459285736084,
0.028431732207536697,
-0.029644977301359177,
0.014404281973838806,
-0.025344062596559525,
0.018150437623262405,
0.02935675159096718,
0.03262244164943695,
-0.023969415575265884,
-0.013719632290303707,
0.03148995712399483,
-0.05742238089442253,
0.03850776329636574,
0.0... |
PMID:17620 | Studies on the mechanism of ristocetin-induced platelet agglutination. Effects of structural modification of ristocetin and vancomycin. | The mechanism by which ristocetin induces platelet agglutination in the presence of the von Willebrand factor was studied by chemically altering ristocetin and a similar antibiotic, vancomycin, by reaction with a water-soluble carbodiimide in the presence of glycine methyl ester at pH 4.75. Altering ristocetin's phenol... | Studies on the mechanism of ristocetin-induced platelet agglutination. Effects of structural modification of ristocetin and vancomycin. The mechanism by which ristocetin induces platelet agglutination in the presence of the von Willebrand factor was studied by chemically altering ristocetin and a similar antibiotic, va... | [
-0.08360494673252106,
-0.025957603007555008,
-0.05170853063464165,
-0.002337957499548793,
0.018296565860509872,
-0.026565004140138626,
0.028410598635673523,
0.07570567727088928,
-0.07265175879001617,
-0.05400915443897247,
0.0010124265681952238,
0.00047968639410100877,
0.03159355744719505,
... |
PMID:17621 | Stabilization of factor VIII in plasma by the von Willebrand factor. Studies on posttransfusion and dissociated factor VIII and in patients with von Willebrand's disease. | In normal plasma, the ratio of the procoagulant activity of factor VIII (VIII(AHF)) to that of the von Willebrand factor activity (ristocetin cofactor, VIII(VWF)) or factor VIII antigen (VIII(AGN)) is approximately 1, but ratios > 1 (e.g., VIII(AHF) > VIII(VWF) or VIII(AGN)) may be observed in some patients with ... | Stabilization of factor VIII in plasma by the von Willebrand factor. Studies on posttransfusion and dissociated factor VIII and in patients with von Willebrand's disease. In normal plasma, the ratio of the procoagulant activity of factor VIII (VIII(AHF)) to that of the von Willebrand factor activity (ristocetin cofacto... | [
-0.06499329209327698,
0.04983700439333916,
-0.016392624005675316,
-0.03351857140660286,
0.02997145801782608,
0.03144058957695961,
0.01830366812646389,
0.05921512842178345,
-0.049745023250579834,
-0.03026098757982254,
0.0019360427977517247,
-0.0840127170085907,
0.0020914641208946705,
-0.010... |
PMID:17623 | Central neurotransmitter substances and aging: a review. | Available evidence suggests that age is an important determinant of the levels of neurotransmitters and their associated enzymes and metabolites in some regions of the brain. Alterations at the synaptic level, or selective cell death in the brain, or both, may be implicated in progressive loss of function, behavioral c... | Central neurotransmitter substances and aging: a review. Available evidence suggests that age is an important determinant of the levels of neurotransmitters and their associated enzymes and metabolites in some regions of the brain. Alterations at the synaptic level, or selective cell death in the brain, or both, may be... | [
-0.026110686361789703,
-0.008993911556899548,
0.0037106885574758053,
-0.0029192795045673847,
-0.017965760082006454,
0.038894470781087875,
0.1254553645849228,
0.025991203263401985,
-0.01227224338799715,
-0.05020721256732941,
0.02761746384203434,
0.008510136045515537,
0.001480735489167273,
0... |
PMID:17626 | The hydrolysis of Zectran in buffered and natural waters. | The analyses and rates of hydrolysis of Zectran, 4-dimethylamino-3,5-xylyl methylcarbamate are reported in aqueous media. These rates were measured in phosphate buffered, distilled water and in natural waters where tempteratures of 10 degrees, 20 degrees, and 28 degrees C. and pH values of 5.94, 7.00, and 8.42 were use... | The hydrolysis of Zectran in buffered and natural waters. The analyses and rates of hydrolysis of Zectran, 4-dimethylamino-3,5-xylyl methylcarbamate are reported in aqueous media. These rates were measured in phosphate buffered, distilled water and in natural waters where tempteratures of 10 degrees, 20 degrees, and 28... | [
-0.02482284978032112,
-0.005301403813064098,
0.009167410433292389,
0.030492471531033516,
0.01566547155380249,
-0.0961625948548317,
0.01483932975679636,
0.05812283605337143,
-0.06906528770923615,
-0.039627958089113235,
0.016106944531202316,
-0.03431035950779915,
-0.004236446227878332,
-0.00... |
PMID:17639 | Immunofixation after electrofocusing: improved method for specific detection of serum proteins with determination of isoelectric points. I. Immunofixation print technique for detection of alpha-1-protease inhibitor. | An improved method is described for direct localization of human serum proteins in polyacrylamide gel with simultaneous determination of their isoelectric points (pI). The technique employs isoelectric focusing in thin-layer polyacrylamide gels to separate the serum proteins and the pH gradient is read at 4 degrees C w... | Immunofixation after electrofocusing: improved method for specific detection of serum proteins with determination of isoelectric points. I. Immunofixation print technique for detection of alpha-1-protease inhibitor. An improved method is described for direct localization of human serum proteins in polyacrylamide gel wi... | [
-0.06066101789474487,
0.010487567633390427,
0.025696706026792526,
-0.02274223230779171,
-0.023200148716568947,
-0.00443275598809123,
0.10590936988592148,
0.046099867671728134,
-0.05360063537955284,
0.006600975524634123,
0.036022450774908066,
-0.0653637945652008,
-0.015805549919605255,
0.05... |
PMID:17640 | Autonomic neuroeffector junctions--reflex vasodilatation of the skin. | A general model of the autonomic neuroeffector junction is proposed. In this model, emphasis is placed on the muscle effector bundle with electrotonic coupling between individual cells via gap junctions (or nexuses) and en passage release of transmitter from autonomic nerve varicosities. This release results in transmi... | Autonomic neuroeffector junctions--reflex vasodilatation of the skin. A general model of the autonomic neuroeffector junction is proposed. In this model, emphasis is placed on the muscle effector bundle with electrotonic coupling between individual cells via gap junctions (or nexuses) and en passage release of transmit... | [
0.0039272429421544075,
-0.002487919991835952,
0.024393701925873756,
0.04003133624792099,
-0.00809747725725174,
-0.02645125985145569,
0.08510591834783554,
0.023929372429847717,
-0.015860632061958313,
-0.060242556035518646,
0.03375600650906563,
-0.08382127434015274,
0.023255309090018272,
0.0... |
PMID:17641 | The Haarscheibe. | The Haarscheibe is a specialized spot of epidermis containing many Merkel cell-neurite complexes. It is a highly sensitive, slowly adapting, modality-specific touch receptor occurring in all mammals. Its exact role in signaling sensation in human beings is undetermined, and the function of Merkel cells, with their dist... | The Haarscheibe. The Haarscheibe is a specialized spot of epidermis containing many Merkel cell-neurite complexes. It is a highly sensitive, slowly adapting, modality-specific touch receptor occurring in all mammals. Its exact role in signaling sensation in human beings is undetermined, and the function of Merkel cells... | [
-0.028138654306530952,
0.04973478615283966,
-0.005876173730939627,
0.057425521314144135,
0.014248790219426155,
-0.01667514443397522,
0.10589303076267242,
0.054465316236019135,
-0.04272076487541199,
0.017204975709319115,
0.0019268346950411797,
-0.13912557065486908,
-0.029066281393170357,
0.... |
PMID:17642 | Factors which influence blood platelet migration. | Migration of human blood platelets in vitro was investigated by a modification of the capillary-tube migration chamber technique used to study the migration inhibition factor of macrophages. Platelets were packed in capillary tubes and incubated in autologous platelet-free plasma (PFP). The extent of migration was quan... | Factors which influence blood platelet migration. Migration of human blood platelets in vitro was investigated by a modification of the capillary-tube migration chamber technique used to study the migration inhibition factor of macrophages. Platelets were packed in capillary tubes and incubated in autologous platelet-f... | [
-0.0973735973238945,
-0.020306043326854706,
-0.02572113461792469,
0.006060224957764149,
-0.004392318893224001,
0.019690485671162605,
0.057831671088933945,
0.017111774533987045,
-0.06486441940069199,
-0.004887836053967476,
0.07591760903596878,
-0.059672050178050995,
0.0024954157415777445,
-... |
PMID:17643 | Intestinal absorption of alpha-tocopherol in the unanesthetized rat. The influence of luminal constituents on the absorptive process. | 3H-alpha-tocopherol intestinal absorption was studied in the unanesthetized rat. The rate of alpha-tocopherol absorption remained linear over a wide range of concentrations (4 nM to 400 micrometer). Increasing the sodium taurocholate concentration in the micellar infusate up to 15 mM did not increase the rate of absorp... | Intestinal absorption of alpha-tocopherol in the unanesthetized rat. The influence of luminal constituents on the absorptive process. 3H-alpha-tocopherol intestinal absorption was studied in the unanesthetized rat. The rate of alpha-tocopherol absorption remained linear over a wide range of concentrations (4 nM to 400 ... | [
-0.026151010766625404,
-0.002659966005012393,
-0.039263658225536346,
0.0004278174019418657,
0.039471372961997986,
-0.024511082097887993,
0.04221539571881294,
0.04202403500676155,
-0.04172709584236145,
-0.026568815112113953,
0.07503486424684525,
-0.07041822373867035,
0.049231790006160736,
-... |
PMID:17644 | The defect of uric acid metabolism in Eck-fistula rats. | Because of the discovery of uric acid urolithiasis in rats after end-to-side portacaval anastomosis (PCA), uric acid metabolism was studied in these animals and in appropriate controls. Hyperuricemia and hyperuricosuria were observed in all experimental rats. The fraction of purine catabolites excreted in the urine as ... | The defect of uric acid metabolism in Eck-fistula rats. Because of the discovery of uric acid urolithiasis in rats after end-to-side portacaval anastomosis (PCA), uric acid metabolism was studied in these animals and in appropriate controls. Hyperuricemia and hyperuricosuria were observed in all experimental rats. The ... | [
-0.05207691341638565,
-0.014044362120330334,
0.04084433987736702,
0.0029186506289988756,
-0.028901541605591774,
0.02769114449620247,
0.02894693799316883,
0.03717353194952011,
-0.029832204803824425,
0.03836841508746147,
0.05280937999486923,
-0.13143831491470337,
0.05013427883386612,
0.01549... |
PMID:17647 | Induction of specific tissue transplantation tolerance using fractionated total lymphoid irradiation in adult mice: long-term survival of allogeneic bone marrow and skin grafts. | BALB/c mice were treated with fractionated high dose (3,400 rads) total lymphoid irradiation (TLI), and given semiallogeneic (BALB/c x C57BL/Ka) or allogeneic (C57BL/Ka) bone marrow and/or skin allografts. TLI alone prolonged the mean survival time (m.s.t.) of C57BL/Ka skin grafts to 49.1 days (control, 10.7 days). Shi... | Induction of specific tissue transplantation tolerance using fractionated total lymphoid irradiation in adult mice: long-term survival of allogeneic bone marrow and skin grafts. BALB/c mice were treated with fractionated high dose (3,400 rads) total lymphoid irradiation (TLI), and given semiallogeneic (BALB/c x C57BL/K... | [
-0.04524853080511093,
0.010328282602131367,
-0.020943857729434967,
0.018315691500902176,
0.02253929153084755,
-0.02600298449397087,
0.01940692402422428,
0.06639888137578964,
-0.06630398333072662,
0.007502730470150709,
0.034714099019765854,
-0.05011900141835213,
-0.010307584889233112,
-0.01... |
PMID:17648 | The phosphoenol-pyruvate branchpoint in adult Hymenolepis diminuta (Cestoda): a study of pyruvate kinase and phosphoenol-pyruvate carboxykinase. | The properties of pyruvate kinase (PK) and phosphoenol pyruvate carboxykinase (PEP CK), two enzymes that determine the preferrential accumulation of either succinate or lactate as endproducts of carbohydrate metabolism, are described in adult Hymenolepis diminuta. PK activity at Vmax and Km levels of PEP was unaffected... | The phosphoenol-pyruvate branchpoint in adult Hymenolepis diminuta (Cestoda): a study of pyruvate kinase and phosphoenol-pyruvate carboxykinase. The properties of pyruvate kinase (PK) and phosphoenol pyruvate carboxykinase (PEP CK), two enzymes that determine the preferrential accumulation of either succinate or lactat... | [
-0.0450388640165329,
-0.042028892785310745,
0.003982807509601116,
0.00615437189117074,
0.03492601960897446,
-0.045345861464738846,
0.04094855859875679,
0.046345457434654236,
-0.0877244845032692,
-0.030788322910666466,
0.04074684530496597,
-0.0853896290063858,
0.01788027584552765,
0.0550759... |
PMID:17650 | The biosynthesis of a choline nucleotide by a cell-free extract from Streptococcus pneumoniae. | Choline, a component of the wall teichoic acid of Streptococcus pneumoniae, was converted to cytidine diphosphocholine via choline phosphate by enzymes which were identified in cell-free extracts of the pneumococcus. The first enzyme, choline kinase, was investigated in some detail. It appeared to have a pH optimum of ... | The biosynthesis of a choline nucleotide by a cell-free extract from Streptococcus pneumoniae. Choline, a component of the wall teichoic acid of Streptococcus pneumoniae, was converted to cytidine diphosphocholine via choline phosphate by enzymes which were identified in cell-free extracts of the pneumococcus. The firs... | [
-0.0739799439907074,
0.019756551831960678,
-0.031458381563425064,
-0.02193848229944706,
-0.02066873200237751,
-0.0395859070122242,
0.02464876137673855,
0.047568608075380325,
-0.02018759772181511,
0.006697208154946566,
0.015280235558748245,
-0.07763867825269699,
0.008389321155846119,
-0.047... |
PMID:17659 | Childhood pheochromocytoma: treatment with alpha methyl tyrosine for resistant hypertension. | A 12-year-old boy with a norepinephrine-secreting pheochromocytoma that caused hypertension resistant to oral alpha adrenergic blockade is reported. Resistance to alpha adrenergic blocking agents developed when the patient's daily propranolol dosage was lowered from 10 to 1 mg/kg. Subsequently, alpha methyl tyrosine, a... | Childhood pheochromocytoma: treatment with alpha methyl tyrosine for resistant hypertension. A 12-year-old boy with a norepinephrine-secreting pheochromocytoma that caused hypertension resistant to oral alpha adrenergic blockade is reported. Resistance to alpha adrenergic blocking agents developed when the patient's da... | [
-0.05447688698768616,
0.0226075891405344,
-0.04750388115644455,
0.02444988489151001,
-0.053100232034921646,
0.02095930464565754,
0.06341882050037384,
0.01310066506266594,
-0.053902484476566315,
-0.051620662212371826,
0.013387375511229038,
-0.0026936884969472885,
-0.004103447310626507,
0.04... |
PMID:17661 | A syndrome of childhood polyarteritis. | In this report the clinical, laboratory, and histopathologic findings of nine children with polyarteritis are reviewed. All have had evidence of systemic involvement. Eight presented with fever, calf pain, erythematous painful nodules, and elevation of the acute-phase reactants. All were treated with prednisone at a do... | A syndrome of childhood polyarteritis. In this report the clinical, laboratory, and histopathologic findings of nine children with polyarteritis are reviewed. All have had evidence of systemic involvement. Eight presented with fever, calf pain, erythematous painful nodules, and elevation of the acute-phase reactants. A... | [
-0.03713839501142502,
-0.025322560220956802,
0.07991590350866318,
0.0043129222467541695,
-0.01047584693878889,
-0.052783455699682236,
0.021174367517232895,
0.045305877923965454,
-0.03483755886554718,
-0.03875349089503288,
0.034904371947050095,
-0.04370041564106941,
0.02433708868920803,
0.0... |
PMID:17662 | Necrotizing arteritis in acute poststreptococcal glomerulonephritis: report of a recovered case. | A patient with biopsy documented acute poststreptococcal glomerulonephritis and arteritis recovered completely with supportive therapy. Illness was preceded by group A streptococcal pharyngitis. At the time of presentation, serum creatinine concentration was 11.5 mg/dl. Serum cryoglobulins containing IgG and C3 were pr... | Necrotizing arteritis in acute poststreptococcal glomerulonephritis: report of a recovered case. A patient with biopsy documented acute poststreptococcal glomerulonephritis and arteritis recovered completely with supportive therapy. Illness was preceded by group A streptococcal pharyngitis. At the time of presentation,... | [
-0.04009665921330452,
0.022418206557631493,
0.010134337469935417,
-0.03700999915599823,
0.007364073768258095,
-0.015034103766083717,
0.04791746661067009,
0.08157515525817871,
-0.03368043154478073,
0.024383507668972015,
0.017570918425917625,
-0.05806376412510872,
0.02713269554078579,
0.0150... |
PMID:17663 | Studies in acid-base balance. I. Effect of alkali therapy in newborn dogs with mechanically fixed ventilation. | The effect of rapid or slow infusion of hypertonic sodium bicarbonate on acid-base balance and serum osmolality was studied in 36 acidotic newborn dogs. Respiratory acidosis and hypoxia were produced by mechanically fixed hypoventilation. One group of animals breathed 100% O2 to prevent hypoxemia. Rapid infusion of HCO... | Studies in acid-base balance. I. Effect of alkali therapy in newborn dogs with mechanically fixed ventilation. The effect of rapid or slow infusion of hypertonic sodium bicarbonate on acid-base balance and serum osmolality was studied in 36 acidotic newborn dogs. Respiratory acidosis and hypoxia were produced by mechan... | [
-0.06934316456317902,
-0.0061096735298633575,
-0.016580043360590935,
0.0581195168197155,
-0.02279623970389366,
-0.016435952857136726,
0.033906612545251846,
0.02104458585381508,
-0.047658707946538925,
0.0032615060918033123,
0.036031171679496765,
-0.09288808703422546,
0.0038010079879313707,
... |
PMID:17665 | Mullerian inhibiting substance in human testes after birth. | Tiny testicular biopsies from humans were assayed for Mullerian inhibiting Substances using a graded organ culture technique. Mullerian Inhibiting Substance activity was high during the first year of life, declined during the second year of life, and then disappeared. Mullerian Inhibiting Substance activity is lower in... | Mullerian inhibiting substance in human testes after birth. Tiny testicular biopsies from humans were assayed for Mullerian inhibiting Substances using a graded organ culture technique. Mullerian Inhibiting Substance activity was high during the first year of life, declined during the second year of life, and then disa... | [
0.0028911572881042957,
0.06458962708711624,
0.006832462269812822,
0.008639316074550152,
0.0007475301972590387,
0.017912371084094048,
0.06479015201330185,
0.03132515773177147,
-0.041912443935871124,
-0.015094236470758915,
0.04947761446237564,
-0.006872125435620546,
0.0563664585351944,
0.027... |
PMID:17667 | Pharmaceutical suspensions: relation between zeta potential, sedimentation volume and suspension stability. | The effect of added surface-active agents of various ionic types on the sedimentation volume of drug suspensions of betamethasone, griseofulvin, nalidixic acid and thiabendazole has been investigated, and the results correlated with previously measured zeta potentials. Study of the zeta potential/sedimentation volumes ... | Pharmaceutical suspensions: relation between zeta potential, sedimentation volume and suspension stability. The effect of added surface-active agents of various ionic types on the sedimentation volume of drug suspensions of betamethasone, griseofulvin, nalidixic acid and thiabendazole has been investigated, and the res... | [
-0.0620056688785553,
-0.026913167908787727,
-0.0067649828270077705,
-0.032691799104213715,
-0.05181233212351799,
-0.0162144023925066,
0.0331876315176487,
0.04037828370928764,
-0.034122366458177567,
-0.026879532262682915,
-0.030154287815093994,
-0.05484767630696297,
0.03634238988161087,
0.0... |
PMID:17668 | The in vitro bioavailability of various drugs formulated as hard gelatin capsules. | A factorially designed experiment has been carried out to study the influence of various additives on the in vitro release of drug from hard gelatin capsules. Analysis of variance confirms previous findings that, although the main factors of diluent type, diluent concentration, the absence and presence of both magnesiu... | The in vitro bioavailability of various drugs formulated as hard gelatin capsules. A factorially designed experiment has been carried out to study the influence of various additives on the in vitro release of drug from hard gelatin capsules. Analysis of variance confirms previous findings that, although the main factor... | [
-0.031266532838344574,
-0.0003643463714979589,
-0.026218945160508156,
-0.006656259298324585,
0.024529848247766495,
0.028028469532728195,
0.08270528167486191,
0.027494650334119797,
-0.022300241515040398,
-0.038033850491046906,
-0.014729849994182587,
-0.014568873681128025,
0.06020776554942131,... |
PMID:17664 | Extraocular muscle transplantation. | 1. The transplantation of extraocular homografts in dogs and humans has been described. 2. The extraocular muscle tissue transplanted remains viable, but loses its characteristics of muscle tissue during the period of the normal healing process following extraocular muscle surgery. 3. Autogenous homograft of extraocula... | Extraocular muscle transplantation. 1. The transplantation of extraocular homografts in dogs and humans has been described. 2. The extraocular muscle tissue transplanted remains viable, but loses its characteristics of muscle tissue during the period of the normal healing process following extraocular muscle surgery. 3... | [
-0.021078214049339294,
-0.07930081337690353,
0.024056226015090942,
-0.009285402484238148,
0.002695988630875945,
-0.029812902212142944,
0.03132366016507149,
0.06310277432203293,
-0.08139341324567795,
0.052188873291015625,
-0.007204579655081034,
-0.04232090339064598,
-0.029863692820072174,
-... |
PMID:17669 | Phase equilibria and stability characteristics of chlorpropamide-urea solid dispersions. | Physical mixtures and melts of various compositions of chlorpropamide and urea have been prepared. The phase diagrams and the effects of ageing of the systems have been measured by differential scanning calorimetry. The eutectic composition was found to contain 89% w/w chlorpropamide. Greater concentrations of chlorpro... | Phase equilibria and stability characteristics of chlorpropamide-urea solid dispersions. Physical mixtures and melts of various compositions of chlorpropamide and urea have been prepared. The phase diagrams and the effects of ageing of the systems have been measured by differential scanning calorimetry. The eutectic co... | [
-0.09036904573440552,
-0.018670884892344475,
0.02388915605843067,
-0.027936629951000214,
0.016089148819446564,
0.045796193182468414,
-0.020708071067929268,
0.025732221081852913,
-0.06373605877161026,
-0.016434136778116226,
0.00827696267515421,
-0.031828831881284714,
0.05812912434339523,
0.... |
PMID:17670 | Derivatization to stabilize some aliphatic primary hydroxylamines for g.l.c. analysis. | By appropriate choice of trimethylsilylating and trifluoroacetylating reagents and organic solvents for extraction, stable derivative of aliphatic primary hydroxylamines metabolites, N-hydroxyphentermine, N-hydroxychlorphentermine, N-hydroxymexiletene, N-hydroxyphenethylamine, N-hydroxyamphetamine, and N-hydroxy-3,4-di... | Derivatization to stabilize some aliphatic primary hydroxylamines for g.l.c. analysis. By appropriate choice of trimethylsilylating and trifluoroacetylating reagents and organic solvents for extraction, stable derivative of aliphatic primary hydroxylamines metabolites, N-hydroxyphentermine, N-hydroxychlorphentermine, N... | [
-0.052387792617082596,
-0.012494259513914585,
-0.002718276809900999,
0.0018287718994542956,
0.011436611413955688,
0.016790660098195076,
0.011832915246486664,
-0.02504156529903412,
-0.0902729332447052,
-0.04476003721356392,
-0.014700460247695446,
-0.011594370007514954,
-0.0014586210018023849,... |
PMID:17672 | Carrageenan and thrombin trigger prostaglandin synthetase-independent aggregation of rabbit platelets: inhibition by phospholipase A2 inhibitors. | Acetylsalicylic acid, salicylic acid and indomethacin were equally effective in inhibiting aggregation of plasma-free rabbit platelets induced by carrageenan and by thrombin. In contrast, only acetylsalicylic acid and indomethacin suppressed the accompanying formation of prostaglandin-like activities. Blockade of aggre... | Carrageenan and thrombin trigger prostaglandin synthetase-independent aggregation of rabbit platelets: inhibition by phospholipase A2 inhibitors. Acetylsalicylic acid, salicylic acid and indomethacin were equally effective in inhibiting aggregation of plasma-free rabbit platelets induced by carrageenan and by thrombin.... | [
-0.0789121463894844,
-0.031485673040151596,
-0.07476790249347687,
0.014997468329966068,
-0.0007619352545589209,
0.020843390375375748,
0.05337990075349808,
0.018551835790276527,
-0.06789863854646683,
-0.012026399374008179,
0.09171316027641296,
-0.04645346477627754,
0.048450980335474014,
0.0... |
PMID:17673 | The interaction between clonidine and various neuroleptic agents and some benzodiazepine tranquillizers. | The central hypotensive action of clonidine, infused into the vertebral artery of chloralose-anaesthetized cats was antagonized by several phenothiazine-neuroleptics (chlorpromazine, promazine, promethazine, thiethylperazine, thioridazine), by chlorprothixene and to a limited extent by haloperidol administered via the ... | The interaction between clonidine and various neuroleptic agents and some benzodiazepine tranquillizers. The central hypotensive action of clonidine, infused into the vertebral artery of chloralose-anaesthetized cats was antagonized by several phenothiazine-neuroleptics (chlorpromazine, promazine, promethazine, thiethy... | [
-0.06004352495074272,
0.027833683416247368,
-0.043946582823991776,
0.03699316084384918,
-0.030312160030007362,
0.024783022701740265,
0.08318629115819931,
0.06834372133016586,
-0.031054500490427017,
-0.043403368443250656,
-0.013344292528927326,
-0.005118079483509064,
0.031124336645007133,
0... |
PMID:17687 | The enkephalins and opiates: structure-activity relations. | The X-ray structures of 9 "opiate" drugs which exhibit a range of pharmacological activity have been examined in detail leading to the theory that one of the reasons why the enkephalins and related peptides possess morphine-like activity is because they have a tyrosine, and hence a "tyramine", residue at the amino term... | The enkephalins and opiates: structure-activity relations. The X-ray structures of 9 "opiate" drugs which exhibit a range of pharmacological activity have been examined in detail leading to the theory that one of the reasons why the enkephalins and related peptides possess morphine-like activity is because they have a ... | [
-0.025682587176561356,
-0.011268693022429943,
-0.00553069356828928,
-0.01588350161910057,
0.006191018503159285,
0.03651813045144081,
0.08074909448623657,
0.029249800369143486,
-0.007048530504107475,
-0.02242490090429783,
-0.042250752449035645,
-0.04150892421603203,
0.03176209330558777,
0.0... |
PMID:17688 | Stereoselective drug distribution and anticoagulant potency of the enantiomers of phenprocoumon in rats. | The elimination, distribution and anticoagulant activity of S(-)-, R(+)-, and R,S(+/-)- phenoprocoumon were determined in male Wistar-Lewis rats after intravenous injection of a single dose of 0.6 mg kg-1. From the plasma concentrations which elicited the same anticoagulant effect, S(-)-phenprocoumon was 4 to 5 times m... | Stereoselective drug distribution and anticoagulant potency of the enantiomers of phenprocoumon in rats. The elimination, distribution and anticoagulant activity of S(-)-, R(+)-, and R,S(+/-)- phenoprocoumon were determined in male Wistar-Lewis rats after intravenous injection of a single dose of 0.6 mg kg-1. From the ... | [
-0.025867177173495293,
-0.009399532340466976,
-0.018026776611804962,
-0.013710085302591324,
0.07519055902957916,
0.0244876891374588,
0.027666574344038963,
0.05922369286417961,
-0.07059953361749649,
0.02314341813325882,
0.038288287818431854,
-0.025343995541334152,
0.0032250122167170048,
-0.... |
PMID:17689 | The effects of etilefrine on blood vessels in the rat tail. | Etilefrine was found to constrict blood vessels in the rat tail through a mechanism which was partly dependent on the sympathetic nerves present in these vessels. The response to the drug was enhanced by pretreagment with noradrenaline and cocaine, and totally abolished by the alpha-receptor antagonist phentolamine. Wh... | The effects of etilefrine on blood vessels in the rat tail. Etilefrine was found to constrict blood vessels in the rat tail through a mechanism which was partly dependent on the sympathetic nerves present in these vessels. The response to the drug was enhanced by pretreagment with noradrenaline and cocaine, and totally... | [
0.0029089173767715693,
0.02910779044032097,
-0.005463663022965193,
-0.001484525972045958,
0.015336453914642334,
-0.025408929213881493,
0.04603492468595505,
0.018751420080661774,
-0.01936744712293148,
-0.028925076127052307,
0.03677026554942131,
-0.01550808735191822,
-0.002821479458361864,
-... |
PMID:17690 | The effects of prostaglandins E1, E2, F1alpha and F2alpha on guinea-pig ileal and colonic peristalis. | Prostaglandins (PGE1, E2, F1alpha and F2alpha) have been tested on the peristaltic reflex in isolated segments of guinea-pig ileum and colon using simultaneous recordings of fluid propulsion and longitudinal and circular muscle activity. Propulsion and circular muscle peristaltic activity were increased by serosally ap... | The effects of prostaglandins E1, E2, F1alpha and F2alpha on guinea-pig ileal and colonic peristalis. Prostaglandins (PGE1, E2, F1alpha and F2alpha) have been tested on the peristaltic reflex in isolated segments of guinea-pig ileum and colon using simultaneous recordings of fluid propulsion and longitudinal and circu... | [
-0.030430378392338753,
-0.018934376537799835,
0.021828744560480118,
-0.02026461809873581,
0.009274006821215153,
-0.0007846876978874207,
0.012777836062014103,
0.05565252527594566,
-0.009201420471072197,
-0.0569000206887722,
0.025538809597492218,
-0.09977342933416367,
0.007407572586089373,
-... |
PMID:17691 | The identification and analysis of mexiletine and its metabolic products in man. | Sensitive and specific gas-liquid chromatographic methods were developed for the analysis of mexiletine and its metabolites in urine of man. The identity of the g.l.c. peaks was established by mass-spectrometry. The hydroxylamine (Va) was qualitatively identified and determined quantitatively after conversion to the mo... | The identification and analysis of mexiletine and its metabolic products in man. Sensitive and specific gas-liquid chromatographic methods were developed for the analysis of mexiletine and its metabolites in urine of man. The identity of the g.l.c. peaks was established by mass-spectrometry. The hydroxylamine (Va) was ... | [
-0.02472628653049469,
0.037101488560438156,
-0.010187733918428421,
-0.02162403240799904,
0.09004427492618561,
0.011360866948962212,
0.04293026775121689,
-0.027311738580465317,
-0.041641395539045334,
-0.014696440659463406,
-0.0022081704810261726,
-0.04591032490134239,
-0.007713691797107458,
... |
PMID:17692 | The decomposition of acidic and neutral cannabinoids in organic solvents. | High-pressure liquid chromatography was used to study (a) the relative efficiencies of methanol, chloroform, light petroleum (B.P. 40-60 degrees) and methanol-chloroform (9:1) for extracting neutral and acidic cannabinoids from cannabis resin; (b) the decomposition patterns of the resulting solutions under various stor... | The decomposition of acidic and neutral cannabinoids in organic solvents. High-pressure liquid chromatography was used to study (a) the relative efficiencies of methanol, chloroform, light petroleum (B.P. 40-60 degrees) and methanol-chloroform (9:1) for extracting neutral and acidic cannabinoids from cannabis resin; (b... | [
-0.02216452918946743,
-0.01568140834569931,
-0.02548355422914028,
-0.046271003782749176,
0.036095041781663895,
-0.004940744023770094,
0.04318305104970932,
-0.003659159177914262,
-0.06763584911823273,
-0.027756735682487488,
-0.023406097665429115,
-0.028478581458330154,
0.01689882203936577,
... |
PMID:17693 | Application of orthogonal functions to the spectrophotometric determination of phenytoin in pharmaceutical preparations. | A simple ultraviolet spectrophotometric method for the determination of phenytoin in pharmaceutical preparations has been developed. The mean was 100.9% (6 determinations) and the coefficient of variation was 1.2%. The method was applied successfully to the determination of phenytoin in capsules and suspensions. | Application of orthogonal functions to the spectrophotometric determination of phenytoin in pharmaceutical preparations. A simple ultraviolet spectrophotometric method for the determination of phenytoin in pharmaceutical preparations has been developed. The mean was 100.9% (6 determinations) and the coefficient of vari... | [
-0.08665676414966583,
0.018520144745707512,
-0.0004049449635203928,
-0.09087606519460678,
0.03613835573196411,
-0.007522203493863344,
0.08384612202644348,
0.06034906953573227,
-0.06943362206220627,
0.054877184331417084,
0.014786326326429844,
-0.03924998641014099,
0.06393426656723022,
0.009... |
PMID:17694 | The influence of additives on the presentation of a drug in hard gelatin capsules. | The influence of the concentration of lactose, magnesium stearate and sodium lauryl sulphate in the in vitro dissolution and the drug content of hard gelatin capsules filled under conditions which result in a maximum tapped bulk density, has been evaluated by a factorially-designed experiment. The 3 factors have a sig... | The influence of additives on the presentation of a drug in hard gelatin capsules. The influence of the concentration of lactose, magnesium stearate and sodium lauryl sulphate in the in vitro dissolution and the drug content of hard gelatin capsules filled under conditions which result in a maximum tapped bulk density... | [
-0.033784039318561554,
-0.042007848620414734,
0.00301046809181571,
-0.004644759930670261,
-0.0024092737585306168,
0.011519845575094223,
0.08156279474496841,
0.04047670215368271,
-0.05345717817544937,
-0.04307807981967926,
0.0014756566379219294,
-0.009165181778371334,
0.03588520735502243,
-... |
PMID:17695 | The distribution of components in the different size fractions of granules prepared from binary mixtures. | Boric acid, sulphanilamide and citric acid have been mixed separately with lactose and then granulated by massing and screening. The granules have been fractionated by sieving and each fraction has been analysed for lactose content. The effect of premixing time, massing time, binder volume and ratio of components on th... | The distribution of components in the different size fractions of granules prepared from binary mixtures. Boric acid, sulphanilamide and citric acid have been mixed separately with lactose and then granulated by massing and screening. The granules have been fractionated by sieving and each fraction has been analysed fo... | [
-0.022534767165780067,
-0.022688888013362885,
-0.028065407648682594,
-0.017287513241171837,
0.03708270937204361,
0.03019406832754612,
0.02599336765706539,
-0.0110090933740139,
0.02067664824426174,
-0.028197776526212692,
-0.02475067786872387,
-0.09839867055416107,
0.00909925065934658,
0.015... |
PMID:17708 | Desensitization to portrayals of real-life aggression as a function of exposure to television violence. | In two separate experiments, the hypothesis that exposure to violence in the context of television drama decreases subjects' emotional responsivity to portrayals of real-life aggression was tested. Subjects were shown either an excerpt from a violent police drama or a segment of an exciting but nonviolent volley-ball g... | Desensitization to portrayals of real-life aggression as a function of exposure to television violence. In two separate experiments, the hypothesis that exposure to violence in the context of television drama decreases subjects' emotional responsivity to portrayals of real-life aggression was tested. Subjects were show... | [
-0.01540086604654789,
0.03244564309716225,
0.025420747697353363,
-0.019388509914278984,
0.09945594519376755,
0.0673893615603447,
0.023034052923321724,
-0.0038659009151160717,
-0.008245691657066345,
-0.013965594582259655,
0.05404166132211685,
0.008608413860201836,
0.006035971455276012,
0.02... |
PMID:17710 | Determination of aqueous solubility and pKa values of estrogens. | Reported estrone pKa and solubility data show wide variation. Improved experimental procedures were designed and used to obtain reproducible results. The pKa values for several estrogens and related compounds also were determined to assess the effects of structural differences on ionization. No evidence was obtained fo... | Determination of aqueous solubility and pKa values of estrogens. Reported estrone pKa and solubility data show wide variation. Improved experimental procedures were designed and used to obtain reproducible results. The pKa values for several estrogens and related compounds also were determined to assess the effects of ... | [
0.0036184072960168123,
-0.06901795417070389,
-0.057335689663887024,
0.007404119707643986,
0.020049070939421654,
-0.03560636192560196,
0.00045824036351405084,
0.034209802746772766,
-0.012345533818006516,
-0.023710031062364578,
-0.00476009352132678,
-0.02848884090781212,
0.006541795562952757,
... |
PMID:17711 | Acetylacroninium salts as soluble prodrugs of the antineoplastic agent acronine. | The low aqueous solubility of acronine (approximately 2 mg/liter) has been overcome by identification of quaternary prodrug salts exhibiting apparent molar solubilities two to five orders of magnitude greater than acronine. The synthesis and kinetics of hydrolysis of the various prodrug acetylacroninium salts were stud... | Acetylacroninium salts as soluble prodrugs of the antineoplastic agent acronine. The low aqueous solubility of acronine (approximately 2 mg/liter) has been overcome by identification of quaternary prodrug salts exhibiting apparent molar solubilities two to five orders of magnitude greater than acronine. The synthesis a... | [
-0.08685415238142014,
-0.0380360446870327,
-0.06709254533052444,
-0.012736108154058456,
0.027635963633656502,
0.0070299506187438965,
0.0021360721439123154,
-0.0016489271074533463,
-0.06961876899003983,
-0.04124649986624718,
0.04724247008562088,
-0.04709184169769287,
0.02086557261645794,
0.... |
PMID:17712 | Microencapsulation of phenobarbital by spray polycondensation. | A new method for the microencapsulation of solids is described. It is based on the polycondensation of amphiphilic and, thus, tensioactive precondensates on a melamine-formaldehyde base on the surface of suspended particles during spray drying. A film-forming agent, preferably one that reacts chemically with the resin,... | Microencapsulation of phenobarbital by spray polycondensation. A new method for the microencapsulation of solids is described. It is based on the polycondensation of amphiphilic and, thus, tensioactive precondensates on a melamine-formaldehyde base on the surface of suspended particles during spray drying. A film-formi... | [
-0.017331698909401894,
0.03415713831782341,
0.03163662925362587,
-0.020325951278209686,
0.0008272304548881948,
-0.002555850660428405,
0.027127975597977638,
0.008194348774850368,
-0.012991408817470074,
0.0029712298419326544,
-0.0659666508436203,
-0.07158088684082031,
0.03426823765039444,
0.... |
PMID:17713 | Quantitative analysis of degradation products in pilocarpine hydrochloride ophthalmic formulations. | The presence of isopilocarpine, an epimer of pilocarpine, and of pilocarpinic acid, a hydrolytic degradation product of pilocarpine, was established and all three substances were assayed in various commercial ophthalmic formulations of pilocarpine hydrochloride by 13C-Fourier transform spectroscopy. Assay was based upo... | Quantitative analysis of degradation products in pilocarpine hydrochloride ophthalmic formulations. The presence of isopilocarpine, an epimer of pilocarpine, and of pilocarpinic acid, a hydrolytic degradation product of pilocarpine, was established and all three substances were assayed in various commercial ophthalmic ... | [
-0.055128440260887146,
-0.001712201745249331,
0.022511428222060204,
-0.02198697254061699,
-0.000818601343780756,
-0.03832285851240158,
0.042686887085437775,
0.0703725814819336,
-0.09302867203950882,
0.010526349768042564,
0.020776117220520973,
-0.05800207704305649,
0.0051848748698830605,
0.... |
PMID:17714 | Determination of meclizine hydrochloride by ion-pair extraction with methyl orange. | A method, based on ion-pair extraction, is described for the quantification of meclizine hydrochloride in various pharmaceutical dosage forms, for content uniformity determination, and for concentration monitoring in dissolution and bioavailability studies. Methyl orange, dissolved in pH 2.8 MacIlvaine buffer, gave exc... | Determination of meclizine hydrochloride by ion-pair extraction with methyl orange. A method, based on ion-pair extraction, is described for the quantification of meclizine hydrochloride in various pharmaceutical dosage forms, for content uniformity determination, and for concentration monitoring in dissolution and bio... | [
-0.07405271381139755,
0.0068259271793067455,
-0.033129189163446426,
0.012187699787318707,
-0.004501350224018097,
-0.06988389790058136,
0.0679071769118309,
0.06390209496021271,
-0.008657373487949371,
-0.029574595391750336,
-0.026334166526794434,
-0.10046236217021942,
0.01805710420012474,
-0... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.