id stringlengths 7 10 | title stringlengths 8 354 | content stringlengths 91 4.1k | contents stringlengths 164 4.24k | embedding listlengths 384 384 |
|---|---|---|---|---|
PMID:18305 | Determination of the Tamm and Horsfall glycoprotein in human urine. | A method for the routine determination of the Tamm and Horsfall glycoprotein in human urine is presented. The method is based on quantitative electroimmunoassay. It was demonstrated that the solubility of the Tamm and Horsfall glycoprotein was dependent on urinary ionic strength and pH. To minimize these variables all ... | Determination of the Tamm and Horsfall glycoprotein in human urine. A method for the routine determination of the Tamm and Horsfall glycoprotein in human urine is presented. The method is based on quantitative electroimmunoassay. It was demonstrated that the solubility of the Tamm and Horsfall glycoprotein was dependen... | [
-0.05065510421991348,
0.032613303512334824,
-0.00963210966438055,
0.007918383926153183,
0.04695890098810196,
-0.022847076877951622,
0.0660422295331955,
0.03228926658630371,
-0.04488791152834892,
-0.03706546872854233,
-0.0032778382301330566,
-0.09019369632005692,
0.03440389409661293,
0.0290... |
PMID:18306 | Heterogeneity of erythrocyte pyruvate kinase deficiency and related metabolic disorders in patients with hematological diseases. | In several patients suffering from congenital non-spherocytic hemolytic anemia or from malignant hemotological disorder associated with erythrocyte pyruvate kinase (PK) deficiency, a metabolic study has been carried out involving the following biochemical determinations: assay of red cell enzyme activities; estimation ... | Heterogeneity of erythrocyte pyruvate kinase deficiency and related metabolic disorders in patients with hematological diseases. In several patients suffering from congenital non-spherocytic hemolytic anemia or from malignant hemotological disorder associated with erythrocyte pyruvate kinase (PK) deficiency, a metaboli... | [
-0.05011909827589989,
0.010891069658100605,
-0.02956489659845829,
-0.00020859207143075764,
-0.018623288720846176,
-0.03380715847015381,
0.023696592077612877,
0.021358896046876907,
-0.07420407235622406,
0.025085048750042915,
0.05658532306551933,
-0.08645765483379364,
-0.03418675810098648,
0... |
PMID:18312 | Clonidine and the vasodilating beta blocker antihypertensive drug interaction. | Because propranolol is contraindicated in some patients and since clonidine can decrease heart rate and renin release, clonidine was substituted for propranolol in 14 severely hypertensive minoxidil-treated outpatients. Clonidine induced weight loss which, since plasma concentrations were not suppressed, was not due to... | Clonidine and the vasodilating beta blocker antihypertensive drug interaction. Because propranolol is contraindicated in some patients and since clonidine can decrease heart rate and renin release, clonidine was substituted for propranolol in 14 severely hypertensive minoxidil-treated outpatients. Clonidine induced wei... | [
-0.060552798211574554,
-0.013201315887272358,
0.013116486370563507,
0.08194868266582489,
-0.011285820975899696,
-0.027574030682444572,
0.009770136326551437,
0.03294443339109421,
-0.042889490723609924,
-0.041988763958215714,
0.0020280007738620043,
0.03793832287192345,
0.05399821326136589,
0... |
PMID:18310 | Plasmalemmal calcium in cardiac excitation-contraction coupling. | 1. Mammalian heart muscle is extremely sensitive to the external calcium concentration. It reacts to alterations of the external calcium concentration with an immediate adaptation of contractile force. 2. In mammalian heart there is a network of large transverse tubules throughout the cell. These structures are regular... | Plasmalemmal calcium in cardiac excitation-contraction coupling. 1. Mammalian heart muscle is extremely sensitive to the external calcium concentration. It reacts to alterations of the external calcium concentration with an immediate adaptation of contractile force. 2. In mammalian heart there is a network of large tra... | [
-0.07302034646272659,
0.009754728525876999,
0.034447427839040756,
0.03226315975189209,
-0.00619087228551507,
-0.09073451161384583,
0.041227295994758606,
0.0033455928787589073,
-0.002515409840270877,
0.005933480337262154,
0.01414591446518898,
-0.10869798809289932,
-0.023398904129862785,
0.0... |
PMID:18313 | Metabolism of flurazepam by the small intestine. | The metabolism of flurazepam-5-14C has been studied in man following catheterization of the portal and hepatic veins. Flurazepam was administered through a tube into the stomach in one patient and into the duodenum in two patients. Thin-layer chromatographs of portal vein blood showed that there was a rapid and early a... | Metabolism of flurazepam by the small intestine. The metabolism of flurazepam-5-14C has been studied in man following catheterization of the portal and hepatic veins. Flurazepam was administered through a tube into the stomach in one patient and into the duodenum in two patients. Thin-layer chromatographs of portal vei... | [
-0.006222635507583618,
-0.0259291660040617,
0.023651260882616043,
0.012420983985066414,
0.015682773664593697,
-0.01562570594251156,
0.05256088450551033,
0.025608565658330917,
-0.04544403776526451,
-0.0951574444770813,
0.01789276860654354,
-0.03963901102542877,
0.00888547208160162,
-0.02000... |
PMID:18311 | A study in mice of bromo and chloro acylurea analogues of the sedative-hypnotic bromureides. | 1. A series of 1-(2-chloroacyl)ureas, related to the sedative-hypnotic drugs bromvaletone and carbromal, was synthesized and tested in mice to determine central depressant and acute toxic effects. Four 1-(2-bromoacyl)ureas and two 3-halo compounds were included for comparison. 2. Large variations in potency were seen b... | A study in mice of bromo and chloro acylurea analogues of the sedative-hypnotic bromureides. 1. A series of 1-(2-chloroacyl)ureas, related to the sedative-hypnotic drugs bromvaletone and carbromal, was synthesized and tested in mice to determine central depressant and acute toxic effects. Four 1-(2-bromoacyl)ureas and ... | [
-0.05196628347039223,
-0.04843466356396675,
0.0023870680015534163,
0.008525113575160503,
-0.020562972873449326,
0.045379750430583954,
0.013671298511326313,
0.03758513554930687,
-0.02559831738471985,
-0.0036455420777201653,
-0.011939514428377151,
-0.013645553030073643,
0.006448210682719946,
... |
PMID:18316 | The effect of chronic frusemide administration on intracellular potassium, sodium and pH of cardiac and skeletal muscle. | 1. Chronic administration of frusemide in large doses of 4 mg day-1 kg-1 for 3 weeks caused a significant reduction of cell water in rabbit cardiac and skeletal muscle. Intracellular Na+ concentration, intracellular pH and extracellular space was unchanged in both tissues. Intracellular K+ concentration increased sligh... | The effect of chronic frusemide administration on intracellular potassium, sodium and pH of cardiac and skeletal muscle. 1. Chronic administration of frusemide in large doses of 4 mg day-1 kg-1 for 3 weeks caused a significant reduction of cell water in rabbit cardiac and skeletal muscle. Intracellular Na+ concentratio... | [
-0.01307683065533638,
-0.044657737016677856,
0.07270560413599014,
0.020203057676553726,
0.12461402267217636,
-0.05203258618712425,
0.030807586386799812,
-0.021913116797804832,
0.0019853629637509584,
-0.042557183653116226,
0.04763885214924812,
-0.09367091953754425,
0.008732283487915993,
0.0... |
PMID:18319 | Essential facets of radiological diagnosis of extremity trauma. | Trauma to the extremities is sometimes dismissed as relatively unimportant in certain radiologic circles. In many instances, radiologic responsibility is denied and relegated to the orthopedist. Although the radiologic manifestations of much trauma to the extremities is clear cut and does not require sophisticated tech... | Essential facets of radiological diagnosis of extremity trauma. Trauma to the extremities is sometimes dismissed as relatively unimportant in certain radiologic circles. In many instances, radiologic responsibility is denied and relegated to the orthopedist. Although the radiologic manifestations of much trauma to the ... | [
-0.005825642962008715,
0.02406599186360836,
0.07863722741603851,
-0.04388688504695892,
0.07866998761892319,
0.0025191304739564657,
0.049343351274728775,
0.12494301050901413,
-0.016535695642232895,
0.017951393499970436,
-0.011938619427382946,
-0.053415533155202866,
-0.03322119265794754,
0.0... |
PMID:18320 | Some factors affecting testosterone, dihydrotestosterone, 5 alpha-androstan-3 alpha,17 beta-diol and 5 alpha-androstan-3 beta,17 beta-diol secretion by invitro perfused rabbit testes. | Intra-arterial infusion of testosterone-3H gave rise to tritiated dihydrotestosterone, 5 alpha-androstan-3 alpha,17 beta-diol and 5 alpha-androstan-3beta,17 beta-diol in spermatic venous effluent of the perfused rabbit testis-epididymis. Mass spectrometric measurements confirmed that these four androgens were present i... | Some factors affecting testosterone, dihydrotestosterone, 5 alpha-androstan-3 alpha,17 beta-diol and 5 alpha-androstan-3 beta,17 beta-diol secretion by invitro perfused rabbit testes. Intra-arterial infusion of testosterone-3H gave rise to tritiated dihydrotestosterone, 5 alpha-androstan-3 alpha,17 beta-diol and 5 alph... | [
0.013552512973546982,
0.0009787097806110978,
0.012225072830915451,
-0.020114045590162277,
0.04606497287750244,
0.008537032641470432,
0.011699402704834938,
0.020682277157902718,
-0.043896157294511795,
-0.0447683185338974,
0.019393175840377808,
-0.10815895348787308,
0.013191618025302887,
0.0... |
PMID:18322 | Testicular androgen binding protein (ABP) - a parameter of Sertoli cell secretory function. | Using ABP as an index of Sertoli cell secretory function, several important features of the Sertoli cell have emerged: 1. The stimulation of ABP production by FSH clearly points to the Sertoli cell as a target cell for FSH (3,4,9-16,21,24). 2. The dramatic effects of androgens on ABP production both in immature and mat... | Testicular androgen binding protein (ABP) - a parameter of Sertoli cell secretory function. Using ABP as an index of Sertoli cell secretory function, several important features of the Sertoli cell have emerged: 1. The stimulation of ABP production by FSH clearly points to the Sertoli cell as a target cell for FSH (3,4,... | [
0.02133799158036709,
0.03049192950129509,
0.00807192549109459,
-0.034912608563899994,
-0.008649921976029873,
0.009548023343086243,
0.10658543556928635,
0.055516548454761505,
-0.025476038455963135,
-0.03591961786150932,
0.04156426340341568,
-0.06666513532400131,
0.06256065517663956,
0.08219... |
PMID:18324 | Regional assignment of seven genes on chromosome 1 of man by use of man-Chinese hamster somatic cell hybrids. I. Results obtained after hybridization of human cells carrying reciprocal translocations involving chromosome 1. | Regional localization studies of genes coding for human PGD, PPH1, PGM1, UGPP, GuK1, Pep-C, and FH, which have been assigned to chromosome 1, were performed with man-Chinese hamster somatic cell hybrids, Informative hybrids that retained fragments of the human chromosome 1 were produced by fusion of hamster cells with ... | Regional assignment of seven genes on chromosome 1 of man by use of man-Chinese hamster somatic cell hybrids. I. Results obtained after hybridization of human cells carrying reciprocal translocations involving chromosome 1. Regional localization studies of genes coding for human PGD, PPH1, PGM1, UGPP, GuK1, Pep-C, and ... | [
-0.03353746980428696,
-0.025321485474705696,
-0.012579744681715965,
-0.054964106529951096,
-0.011428208090364933,
0.031017599627375603,
0.04192807525396347,
-0.002653314732015133,
0.0044786641374230385,
-0.03681126609444618,
0.059213440865278244,
-0.08715511113405228,
0.007214802782982588,
... |
PMID:18325 | Brain monoamines act through the prostaglandin release to influence the body temperature. | In the present study, the thermal responses induced by intraventicular administration of pyrogen prostaglandin E1, the brain monoamines norepinephrine and serotonin, and the antipyretic sodium acetylsalicylate (aspirin) were measured in conscious rabbits to assess the possible involvement of these substances in fever p... | Brain monoamines act through the prostaglandin release to influence the body temperature. In the present study, the thermal responses induced by intraventicular administration of pyrogen prostaglandin E1, the brain monoamines norepinephrine and serotonin, and the antipyretic sodium acetylsalicylate (aspirin) were measu... | [
-0.05805501714348793,
0.027950508520007133,
-0.017134130001068115,
0.014207863248884678,
0.04476373642683029,
0.03164272755384445,
0.11037561297416687,
0.01697993092238903,
-0.04219488054513931,
-0.07464393228292465,
0.008591221645474434,
-0.0301827322691679,
0.031072106212377548,
0.062740... |
PMID:18328 | [Recurrent periarteritis nodosa with predominantly cerebral signs in children (author's transl)]. | Periarteritis nodosa occurs also in children and has the same wide spectrum of signs and symptoms as in adults. In a 4 1/2 year-old girl the disease at first was characterised by cerebral, encephalitis-like symptoms, arterial hypertension, intestinal wall necrosis and, finally, pericardial tamponade as a result of rupt... | [Recurrent periarteritis nodosa with predominantly cerebral signs in children (author's transl)]. Periarteritis nodosa occurs also in children and has the same wide spectrum of signs and symptoms as in adults. In a 4 1/2 year-old girl the disease at first was characterised by cerebral, encephalitis-like symptoms, arter... | [
-0.021702591329813004,
-0.03822702169418335,
0.02656613290309906,
0.007244555279612541,
-0.006744511891156435,
0.00945119746029377,
0.056483227759599686,
0.06677329540252686,
-0.023612843826413155,
-0.0206026379019022,
0.04202805086970329,
-0.08650427311658859,
0.016699858009815216,
0.0105... |
PMID:18329 | Drug-induced cardiovascular diseases. | A wide variety of drugs may be associated with serious cardiovascular toxicity. Toxicity due to drugs primarily used for treating cardiovascular toxicity. Toxicity due to drugs primarily used for treating cardiac disorders is the most extensively documented, especially the arrhythmias due to digitalis glycosides. Vario... | Drug-induced cardiovascular diseases. A wide variety of drugs may be associated with serious cardiovascular toxicity. Toxicity due to drugs primarily used for treating cardiovascular toxicity. Toxicity due to drugs primarily used for treating cardiac disorders is the most extensively documented, especially the arrhythm... | [
-0.034475505352020264,
0.014764975756406784,
-0.004246771335601807,
0.0056947278790175915,
0.00036449896288104355,
-0.055368416011333466,
0.028655456379055977,
0.05536436662077904,
0.014222432859241962,
-0.047201406210660934,
-0.006072853691875935,
-0.011435579508543015,
0.000286614464130252... |
PMID:18331 | [Telemetry of the tissue Ph value under the effect of local anesthetics. Preliminary report]. | After discussing the problems involved in in vivo pH measurements, pH telemetry is presented as a new method. Long-term in vivo measurements of the pH are intended to be performed by means of a miniature transmitter implanted into the subcutaneous tissue of guinea pigs. | [Telemetry of the tissue Ph value under the effect of local anesthetics. Preliminary report]. After discussing the problems involved in in vivo pH measurements, pH telemetry is presented as a new method. Long-term in vivo measurements of the pH are intended to be performed by means of a miniature transmitter implanted ... | [
-0.02284354344010353,
-0.005652595777064562,
0.05799223855137825,
0.011189442127943039,
0.025493288412690163,
-0.04751095548272133,
0.09117510169744492,
0.07054459303617477,
-0.03323020040988922,
-0.017650971189141273,
0.01870933547616005,
-0.09509246051311493,
-0.002908593975007534,
0.069... |
PMID:18332 | [The salivary fluoride level after administration of fluorides and fluoride complex salts]. | Compounds of fluorine and Si or Fe are found in nature and are sometimes formed from F ions in the stomach. The chemistry of the release of resorbable F ions from such compounds in the intestinal tract is described. To demonstrate fluorine availability at the enamel surface daily profiles of fluorine concentration in t... | [The salivary fluoride level after administration of fluorides and fluoride complex salts]. Compounds of fluorine and Si or Fe are found in nature and are sometimes formed from F ions in the stomach. The chemistry of the release of resorbable F ions from such compounds in the intestinal tract is described. To demonstra... | [
0.009268307127058506,
-0.017303213477134705,
0.017962466925382614,
0.0036333762109279633,
0.03980601578950882,
0.007925253361463547,
0.03516083210706711,
0.06539680063724518,
-0.027101537212729454,
-0.0669253021478653,
-0.009335176087915897,
-0.11946403980255127,
0.02695869281888008,
0.019... |
PMID:18334 | [Change in the mental contents in the paradoxical stage and in stage 2 under the effects of a benzodiazepine, flunitrazepam]. | In some insomniacs under flunitrazepam treatment is noted on one hand a global increase of dream memories, and on the other hand an increase of dreams with unpleasant or anxious contents. The present investigation is intended first to test the hypothesis of a possible increase of mental contents in sleep outside the pa... | [Change in the mental contents in the paradoxical stage and in stage 2 under the effects of a benzodiazepine, flunitrazepam]. In some insomniacs under flunitrazepam treatment is noted on one hand a global increase of dream memories, and on the other hand an increase of dreams with unpleasant or anxious contents. The pr... | [
-0.01119249314069748,
0.041091736406087875,
0.04560762643814087,
0.0634947419166565,
0.01228397898375988,
0.07728523015975952,
0.06303519010543823,
0.027257757261395454,
0.03170394152402878,
-0.07550477981567383,
0.019137006253004074,
0.00020808438421227038,
0.033586613833904266,
0.0131003... |
PMID:18338 | Influence of temperature on the determination of enzyme activities in human serum. gamma-Glutamyl transferase. | Optimum reaction conditions for determination of gamma-glutamyl transferase were studied at 25, 30 and 37 degrees C using a kinetic test and gamma-glutamyl-3-carboxy-4-nitranilide as substrate. There was no dependence on temperature of half saturation constants of gamma-glutamyl-3-carboxy-4-nitranilide. The correspondi... | Influence of temperature on the determination of enzyme activities in human serum. gamma-Glutamyl transferase. Optimum reaction conditions for determination of gamma-glutamyl transferase were studied at 25, 30 and 37 degrees C using a kinetic test and gamma-glutamyl-3-carboxy-4-nitranilide as substrate. There was no de... | [
-0.008625367656350136,
0.053280059248209,
0.024479389190673828,
0.019027793779969215,
0.046471137553453445,
0.005446574650704861,
0.06995713710784912,
0.06191732734441757,
-0.06488284468650818,
-0.04166107252240181,
0.030072566121816635,
-0.03693234920501709,
0.017601268365979195,
0.063815... |
PMID:18339 | Guanosine triphosphate: 5-hydroxylysine phosphotransferase in rat kidney cortex. | An enzyme which catalyzes the transfer of the gamma-phosphate from GTP onto 5-hydroxylysine was partially purified from rat kidney cortex by means of acid precipitation and DEAE-Sephadex A-50 column chromatography. The enzyme activity was assayed by measuring the transfer of [32P] from gamma-[32P]-GTP to materials not ... | Guanosine triphosphate: 5-hydroxylysine phosphotransferase in rat kidney cortex. An enzyme which catalyzes the transfer of the gamma-phosphate from GTP onto 5-hydroxylysine was partially purified from rat kidney cortex by means of acid precipitation and DEAE-Sephadex A-50 column chromatography. The enzyme activity was ... | [
-0.07788054645061493,
-0.03691847622394562,
0.006934732664376497,
-0.029219888150691986,
-0.05776820704340935,
-0.04668520390987396,
0.04089070111513138,
0.046210937201976776,
-0.06506185978651047,
-0.0019707444589585066,
0.014464621432125568,
-0.04425681009888649,
0.0005314901354722679,
-... |
PMID:18340 | Isatin enzyme interactions. V. Activation of rat liver acid phosphatase. | Influence of Isatin on rat tissue acid phosphatase has been studied. It has an organ-specific effect, the liver enzyme is activated, the brain enzyme is inhibited while those of kidney and intestine are not affected. Isatin activation of the liver enzyme is of mixed type and pH dependent. Rat liver enzyme appears to re... | Isatin enzyme interactions. V. Activation of rat liver acid phosphatase. Influence of Isatin on rat tissue acid phosphatase has been studied. It has an organ-specific effect, the liver enzyme is activated, the brain enzyme is inhibited while those of kidney and intestine are not affected. Isatin activation of the liver... | [
-0.01760891079902649,
0.042496029287576675,
-0.020234916359186172,
0.005231230519711971,
0.020945845171809196,
-0.03164609894156456,
0.12030933052301407,
0.06760182231664658,
-0.0571601539850235,
-0.06561138480901718,
0.033744290471076965,
-0.03493066132068634,
-0.03756961598992348,
0.0913... |
PMID:18341 | Effect of cofactor depletion on liver tyrosine aminotransferase expression. | Hepatic tyrosine aminotransferase (L-tyrosine: 2-oxoglutarate aminotransferase, EC 2.6.1.5) was partially purified from pyridoxine depleted and control rats and subsequently resolved by electrophoresis on polyacrylamide gels. Enzyme activity was detected histochemically in situ on the gel. Six enzymatically active form... | Effect of cofactor depletion on liver tyrosine aminotransferase expression. Hepatic tyrosine aminotransferase (L-tyrosine: 2-oxoglutarate aminotransferase, EC 2.6.1.5) was partially purified from pyridoxine depleted and control rats and subsequently resolved by electrophoresis on polyacrylamide gels. Enzyme activity wa... | [
-0.04866611585021019,
0.05186827480792999,
-0.03725876659154892,
0.031128864735364914,
-0.02339048683643341,
0.010292280465364456,
0.05606561899185181,
0.013431877829134464,
-0.07878866791725159,
-0.05599324032664299,
0.03986861929297447,
-0.06499689072370529,
0.03208130970597267,
0.031564... |
PMID:18342 | Interactions of citrate synthases from osmoconforming and osmoregulating animals with salt: possible signs of molecular eco-adaptation? | This study considers differential sensitivity of citrate synthase (citrate oxaloacetatelyase [CoA acetylating]) EC 4.1.3.7. from an osmoconforming animal (sea anemone) and an osmoregulating animal (the pig) to salt. Attention is drawn to the fact that the osmoconforming sea anemone is in essence a sessile creature whil... | Interactions of citrate synthases from osmoconforming and osmoregulating animals with salt: possible signs of molecular eco-adaptation? This study considers differential sensitivity of citrate synthase (citrate oxaloacetatelyase [CoA acetylating]) EC 4.1.3.7. from an osmoconforming animal (sea anemone) and an osmoregul... | [
-0.06679439544677734,
-0.062202490866184235,
-0.04660439491271973,
0.024933306500315666,
0.02789073809981346,
-0.04338803514838219,
0.030408820137381554,
0.001407540519721806,
-0.0457555428147316,
-0.027167601510882378,
0.017166290432214737,
-0.11289957910776138,
-0.0023756222799420357,
-0... |
PMID:18343 | A deoxyribonuclease from Chlamydomonas reinhardii. 1. Purification and properties. | A deoxyribonuclease has been purified more than 2000-fold from the green algae, Chlamydomonas reinhardii. The enzyme is most active on denatured DNA. Optimum activity is at pH 8.5, in 80 mM Tris-HCl buffer and 2 mM CaCl2. Other divalent cations can replace Ca2+ with varying lower efficiency. EDTA and inorganic phosphat... | A deoxyribonuclease from Chlamydomonas reinhardii. 1. Purification and properties. A deoxyribonuclease has been purified more than 2000-fold from the green algae, Chlamydomonas reinhardii. The enzyme is most active on denatured DNA. Optimum activity is at pH 8.5, in 80 mM Tris-HCl buffer and 2 mM CaCl2. Other divalent ... | [
-0.08056820183992386,
-0.04400065913796425,
-0.01834147609770298,
0.0065266829915344715,
0.005116173531860113,
-0.007737740408629179,
0.03589652106165886,
0.04423966631293297,
-0.08425619453191757,
0.021761903539299965,
-0.0062817479483783245,
-0.07121869921684265,
-0.007729591801762581,
0... |
PMID:18344 | Dihydroxyacetone reductase from Mucor javanicus. 1. Isolation and properties. | An NADPH-dependent oxidoreductase has been extracted from the mycelium of the fungus Mucor Javanicus (Wehmer) and enriched 1000-fold with respect to the protein contained in the crude extract after centrifugation at 2600 X g. The molecular weight of the enzyme was estimated by gel filtration to be about 100 000; electr... | Dihydroxyacetone reductase from Mucor javanicus. 1. Isolation and properties. An NADPH-dependent oxidoreductase has been extracted from the mycelium of the fungus Mucor Javanicus (Wehmer) and enriched 1000-fold with respect to the protein contained in the crude extract after centrifugation at 2600 X g. The molecular we... | [
-0.09680096805095673,
-0.002648823894560337,
-0.026463763788342476,
0.006038200575858355,
0.05774407461285591,
-0.04720807448029518,
-0.005982552655041218,
-0.0008406450506299734,
-0.06247611716389656,
-0.005827185697853565,
0.028727177530527115,
-0.08656474947929382,
-0.011781079694628716,
... |
PMID:18348 | On the structure of flavin-oxygen intermediates involved in enzymatic reactions. | During the catalytic reactions of flavoprotein hydroxylases and bacterial luciferase, flavin peroxides are formed as intermediates [see Massey, V. and Hemmerich, P. (1976) in The Enzymes, 3rd edn (P. Boyer, ed.) pp. 421--505, Academic Press, New York]. These intermediates have been postulated to be C(4a) derivatives of... | On the structure of flavin-oxygen intermediates involved in enzymatic reactions. During the catalytic reactions of flavoprotein hydroxylases and bacterial luciferase, flavin peroxides are formed as intermediates [see Massey, V. and Hemmerich, P. (1976) in The Enzymes, 3rd edn (P. Boyer, ed.) pp. 421--505, Academic Pres... | [
-0.09853008389472961,
0.015687918290495872,
-0.0614536814391613,
0.05928044393658638,
0.0418766587972641,
-0.019496483728289604,
0.02174798771739006,
0.023885050788521767,
0.023847902193665504,
0.0011087898164987564,
0.02463170886039734,
-0.03755945339798927,
0.0008184409234672785,
0.00317... |
PMID:18351 | A phosphorus-magnetic-resonance study of the interaction of Mg2+ with adenyl-5'-yl imidodiphosphate. Binding sites of Mg2+ ion on the phosphate chain. | The interaction of Mg2+ ions with adenyl-5'-yl imidodiphosphate, AMP-P(NH)P, has been studied at basic and acidic pH values by phosphorus magnetic resonance spectroscopy in aqueous solution. The results suggest that Mg2+ binds simultaneously to one (or both) of the two free oxygen atoms of the beta-phosphate moiety and... | A phosphorus-magnetic-resonance study of the interaction of Mg2+ with adenyl-5'-yl imidodiphosphate. Binding sites of Mg2+ ion on the phosphate chain. The interaction of Mg2+ ions with adenyl-5'-yl imidodiphosphate, AMP-P(NH)P, has been studied at basic and acidic pH values by phosphorus magnetic resonance spectroscopy... | [
-0.11965161561965942,
0.035253021866083145,
-0.004011800978332758,
-0.020661700516939163,
0.03578838333487511,
-0.04571223631501198,
0.04356899857521057,
0.022093726322054863,
-0.07059012353420258,
-0.0450374111533165,
0.059528689831495285,
-0.07207731157541275,
0.035457052290439606,
-0.00... |
PMID:18352 | Nickel cytochrome c. Effect of protein moiety on the metal ion coordination. | Nickel cytochrome c has been synthesized by the reaction of metal-free porphyrin cytochrome c with Ni(II) ions in 0.6 Mglycylglycine and 4 M KSCN. Electronic spectra and susceptibility measurement showed the nickel to be in a high-spin octahedral configuration exemplifying the strong influence of the protein moiety as ... | Nickel cytochrome c. Effect of protein moiety on the metal ion coordination. Nickel cytochrome c has been synthesized by the reaction of metal-free porphyrin cytochrome c with Ni(II) ions in 0.6 Mglycylglycine and 4 M KSCN. Electronic spectra and susceptibility measurement showed the nickel to be in a high-spin octahed... | [
-0.1103968694806099,
0.028812048956751823,
-0.04853249341249466,
0.03593246638774872,
-0.0037199233192950487,
-0.06924878805875778,
0.06465818732976913,
-0.007240733597427607,
-0.05489257350564003,
0.004837487358599901,
0.03886272758245468,
-0.02034212090075016,
-0.01082697045058012,
0.026... |
PMID:18353 | Anorchi. | Anorchia was diagnosed in 3 patients after a hormonal study entailing the basic determination of FSH, LH and testosterone by a radioimmunoassay technique and by later stimulation with HCG. 2,000 IU are administered during 3 consecutive days with a new testosterone determination 24 and 72 h after the last administration... | Anorchi. Anorchia was diagnosed in 3 patients after a hormonal study entailing the basic determination of FSH, LH and testosterone by a radioimmunoassay technique and by later stimulation with HCG. 2,000 IU are administered during 3 consecutive days with a new testosterone determination 24 and 72 h after the last admin... | [
0.017884712666273117,
0.023599950596690178,
-0.004258533474057913,
0.0073935301043093204,
0.008197407238185406,
0.004306514747440815,
0.08626402914524078,
0.008465969935059547,
-0.06452958285808563,
-0.03163088858127594,
0.05900339409708977,
-0.046575210988521576,
0.0030717733316123486,
0.... |
PMID:18354 | Regional changes in the activities of aminergic biosynthetic enzymes in the brains of hypertensive rats. | The activities of monoamine biosynthetic enzymes were measured in brain regions of several hypertensive rat models at various ages. The types of hypertensive rats were the spontaneously hypertensive rat (SHR) and a stroke-prone substrain of the SHR as well as DOCA-salt and renal hypertensive rats. The genetically hyper... | Regional changes in the activities of aminergic biosynthetic enzymes in the brains of hypertensive rats. The activities of monoamine biosynthetic enzymes were measured in brain regions of several hypertensive rat models at various ages. The types of hypertensive rats were the spontaneously hypertensive rat (SHR) and a ... | [
0.00273033045232296,
0.002382676349952817,
-0.003982020542025566,
-0.009655248373746872,
-0.05962756276130676,
0.03254007175564766,
0.07126283645629883,
-0.002106000669300556,
-0.03036143258213997,
-0.049373332411050797,
-0.006096345838159323,
-0.026197383180260658,
-0.018620435148477554,
... |
PMID:18355 | Some cardiovascular effects of ST-91 and clonidine. | St-91, 2(2,6-diethylphenylamino)-2-imidazoline, is a clonidine derivative which does not penetrate the blood-brain barrier. In spontaneously hypertensive (SH) rats is acutely increased arterial pressure and reduced heart rate while at 8 to 12 h after oral administration, it slightly lowered arterial pressure. In contra... | Some cardiovascular effects of ST-91 and clonidine. St-91, 2(2,6-diethylphenylamino)-2-imidazoline, is a clonidine derivative which does not penetrate the blood-brain barrier. In spontaneously hypertensive (SH) rats is acutely increased arterial pressure and reduced heart rate while at 8 to 12 h after oral administrati... | [
-0.05659857764840126,
0.00341598317027092,
-0.0006999368197284639,
0.056642815470695496,
-0.01882927305996418,
-0.0395502969622612,
0.03557448834180832,
0.05547957494854927,
-0.007179097272455692,
-0.04835142567753792,
-0.005788786336779594,
0.00913242343813181,
0.02951877750456333,
0.0476... |
PMID:18356 | Specific alpha-adrenoceptor blocking effect of droperidol on isolated smooth muscles. | The present study was conducted so as to obtain more insight into the controversies concerning the alpha-adrenoceptor blocking properties of droperidol, a short-acting neuroleptic agent used in neuroleptanalgesia. The effect of droperidol on the vasoconstriction induced by norepinephrine, sympathetic nerve stimulation,... | Specific alpha-adrenoceptor blocking effect of droperidol on isolated smooth muscles. The present study was conducted so as to obtain more insight into the controversies concerning the alpha-adrenoceptor blocking properties of droperidol, a short-acting neuroleptic agent used in neuroleptanalgesia. The effect of droper... | [
-0.047175705432891846,
-0.010182304307818413,
0.01656787097454071,
0.01592584140598774,
0.0251645315438509,
-0.04159832000732422,
0.05796707049012184,
0.024369409307837486,
-0.01453405525535345,
-0.0947139710187912,
0.049301549792289734,
-0.00023798635811544955,
-0.03192007541656494,
0.037... |
PMID:18357 | Withdrawal syndrome upon cessation of chronic clonidine treatment in rats. | Clinical reports indicate that cessation of treatment with the antihypertensive agent clonidine is associated with a withdrawal syndrome which may include a hypertensive overshoot of critical proportions. We have attempted to produce an animal model of this syndrome in rats. Rats were treated with clonidine in the drin... | Withdrawal syndrome upon cessation of chronic clonidine treatment in rats. Clinical reports indicate that cessation of treatment with the antihypertensive agent clonidine is associated with a withdrawal syndrome which may include a hypertensive overshoot of critical proportions. We have attempted to produce an animal m... | [
-0.019537707790732384,
0.01214421633630991,
-0.004842863418161869,
0.08784329891204834,
-0.007595268543809652,
-0.02383553609251976,
0.08372373133897781,
0.017617177218198776,
-0.0017995573580265045,
-0.038510698825120926,
0.005338788032531738,
-0.009959244169294834,
0.025117699056863785,
... |
PMID:18366 | [Effect of various analeptics on the outcome of acute microwave lesion in mice]. | The survival of albino mice irradiated by microwaves till the terminal state (wave length of 12.5 cm, intensity-62 +/- 5 microvat, for 14-16 minutes), given directly after irradiation diethylamide of nicotinic acid (cordiamine) in a dose of 50 mg/kg intraperitoneally and strychnine nitrate in a dose of 1 mg/kg, subcuta... | [Effect of various analeptics on the outcome of acute microwave lesion in mice]. The survival of albino mice irradiated by microwaves till the terminal state (wave length of 12.5 cm, intensity-62 +/- 5 microvat, for 14-16 minutes), given directly after irradiation diethylamide of nicotinic acid (cordiamine) in a dose o... | [
-0.02179492637515068,
0.02696036547422409,
0.01756432093679905,
0.017139775678515434,
0.04620387777686119,
0.009291145950555801,
0.026889536529779434,
0.08444979041814804,
-0.04422478377819061,
-0.03987397626042366,
0.005250467453151941,
-0.038125865161418915,
-0.022477131336927414,
-0.010... |
PMID:18370 | [Effect of corticotropin on functional and metabolic processes in muscles]. | Changes of excitability, contractility, temperature, activity of oxydation-reduction enzymes, pyridine nucleotides, and of free fatty acids were studied in m. m. gastrocnemii of rabbits and rats during activity, after administration of 1 unit per 100 g of corticotropin (ACTH). Within 30 min after administration, the AC... | [Effect of corticotropin on functional and metabolic processes in muscles]. Changes of excitability, contractility, temperature, activity of oxydation-reduction enzymes, pyridine nucleotides, and of free fatty acids were studied in m. m. gastrocnemii of rabbits and rats during activity, after administration of 1 unit p... | [
-0.011805894784629345,
-0.0018476416589692235,
0.04907260462641716,
0.044767044484615326,
0.014642811380326748,
-0.0027926601469516754,
0.04873402416706085,
-0.02742910198867321,
-0.040710486471652985,
-0.06454954296350479,
-0.023935141041874886,
-0.019722014665603638,
-0.03202299028635025,
... |
PMID:18367 | [Relationship between the pain-relieving action of narcotic analgesics and their effect on respiration]. | Experiments with rabbits (30) and albino rats (110) demonstrated that morphine (1 mg/kg), promedol (trimeperidine) (2 mg/kg) and phentanyl (0.02 mg/kg), while raising by 21-24 per cent of the algesia threshold, produced an analgesic effect differeing in its duration (morphine-130 min, trimeperidine-70 min, phentanyl-17... | [Relationship between the pain-relieving action of narcotic analgesics and their effect on respiration]. Experiments with rabbits (30) and albino rats (110) demonstrated that morphine (1 mg/kg), promedol (trimeperidine) (2 mg/kg) and phentanyl (0.02 mg/kg), while raising by 21-24 per cent of the algesia threshold, prod... | [
-0.04401802644133568,
-0.008859410881996155,
0.02123262919485569,
0.010290694423019886,
0.058060191571712494,
0.0009939655428752303,
0.04699661582708359,
0.05118247866630554,
-0.00783330574631691,
-0.0033485221210867167,
0.016461724415421486,
0.009632309898734093,
-0.00265284301713109,
0.0... |
PMID:18371 | Nucleolar and functional characterization of lymphocytes following cyclophosphamide treatment. | Profound lymphocyte depletion occurs in thymus, lymph nodes and spleens of normal and thymectomized mice early after a single high sublethal dose of cyclophosphamide. Among individual lymphocytes characterized by the different types of nucleolus, the "non-activable" lymphocytes with micronucleoli are affected most mark... | Nucleolar and functional characterization of lymphocytes following cyclophosphamide treatment. Profound lymphocyte depletion occurs in thymus, lymph nodes and spleens of normal and thymectomized mice early after a single high sublethal dose of cyclophosphamide. Among individual lymphocytes characterized by the differen... | [
-0.004132762551307678,
-0.005215118173509836,
-0.01728193648159504,
-0.0066333855502307415,
-0.02264997363090515,
-0.016429413110017776,
0.06352929025888443,
0.062367554754018784,
-0.03924361243844032,
-0.03291139006614685,
0.030394259840250015,
-0.009878743439912796,
0.014213955029845238,
... |
PMID:18374 | Evidence for improved cardiac performance after beta-blockade in patients with coronary artery disease. | The study was undertaken to investigate the acute haemodynamic effects of bunitrolol (0-2-hydroxy-3-(tert.butylamino)-propoxy)-bity. Right and left heart catheterization was performed in eleven patients with documented coronary artery disease. After bunitrolol (10 mg i.v.), there was a statistically significant decreas... | Evidence for improved cardiac performance after beta-blockade in patients with coronary artery disease. The study was undertaken to investigate the acute haemodynamic effects of bunitrolol (0-2-hydroxy-3-(tert.butylamino)-propoxy)-bity. Right and left heart catheterization was performed in eleven patients with document... | [
-0.05845068022608757,
0.003181199077516794,
0.0407525971531868,
0.0352463461458683,
0.017812926322221756,
0.03055138699710369,
0.012957682833075523,
0.049304112792015076,
-0.025458863005042076,
-0.050583552569150925,
0.022196898236870766,
-0.052021849900484085,
-0.006415970623493195,
-0.02... |
PMID:18375 | The use of flurazepam (dalmane) as a substitute for barbiturates and methaqualone/diphenhydramine (mandrax) in general practice. | A twelve-week study involving fifty-three patients is described as taking place in a practice with a higher than average geriatric population. The purpose of the study was to substitute flurazepam for habitually used barbiturates or methaqualone/diphenhydramine. Of the original fifty-three patients admitted to the stud... | The use of flurazepam (dalmane) as a substitute for barbiturates and methaqualone/diphenhydramine (mandrax) in general practice. A twelve-week study involving fifty-three patients is described as taking place in a practice with a higher than average geriatric population. The purpose of the study was to substitute flura... | [
-0.017721425741910934,
-0.01291650626808405,
-0.0033250015694648027,
0.05924219265580177,
0.02996828407049179,
-0.007513905875384808,
0.06532105058431625,
0.004971150774508715,
-0.009442021138966084,
-0.07914943248033524,
-0.046259548515081406,
0.0015806577866896987,
-0.003823455423116684,
... |
PMID:18376 | A trial of benorylate tablets in the symptomatic relief of osteoarthritis. | A two-week assessment of Benoral tablets was carried out in general practice in 171 patients with degenerative joint disease to see how symptomatic response related to selected presenting features of the disease. A short history, less severe initial state and multiple joint involvement were each associated with a bette... | A trial of benorylate tablets in the symptomatic relief of osteoarthritis. A two-week assessment of Benoral tablets was carried out in general practice in 171 patients with degenerative joint disease to see how symptomatic response related to selected presenting features of the disease. A short history, less severe ini... | [
-0.016848845407366753,
-0.023890865966677666,
0.04279319569468498,
-0.05360190197825432,
-0.01144714467227459,
-0.0019068543333560228,
-0.0065546790137887,
0.08250188082456589,
-0.037966303527355194,
-0.0641169399023056,
0.0004008101241197437,
-0.027702372521162033,
0.029637247323989868,
0... |
PMID:18377 | Temperature dependence of adenylate cyclase activity from rat white adipocytes. | The effects of temperature on adenylate cyclase (AC) activity from rat white adipocytes were studied. Arrhenius plots of the data were found to be biphasic for basal AC activity, with a break near 27 degrees C. Noradrenaline and corticotropin induced a shift in the break with a rise in energy of activation (Ea) on both... | Temperature dependence of adenylate cyclase activity from rat white adipocytes. The effects of temperature on adenylate cyclase (AC) activity from rat white adipocytes were studied. Arrhenius plots of the data were found to be biphasic for basal AC activity, with a break near 27 degrees C. Noradrenaline and corticotrop... | [
-0.0771573856472969,
-0.023687617853283882,
-0.0023224770557135344,
0.051170557737350464,
0.03254914656281471,
-0.0027904766611754894,
0.04824687913060188,
0.0009953908156603575,
-0.03649101033806801,
-0.07335088402032852,
0.031668249517679214,
-0.032601431012153625,
-0.018155185505747795,
... |
PMID:18380 | Amino acid replacements resulting from suppression and missense reversion of a chain-terminator mutation in Neurospora. | The Neurospora crassa super-suppressor mutation, ssu-1, suppresses the auxotrophic phenotype of the mutant am(17) by inserting tyrosine at residue 313 of NADP-specific glutamate dehydrogenase, a position occupied in the wild type by glutamate. Two classes of am(17) revertants due to further mutation within the am gene ... | Amino acid replacements resulting from suppression and missense reversion of a chain-terminator mutation in Neurospora. The Neurospora crassa super-suppressor mutation, ssu-1, suppresses the auxotrophic phenotype of the mutant am(17) by inserting tyrosine at residue 313 of NADP-specific glutamate dehydrogenase, a posit... | [
-0.058877188712358475,
0.0002120504796039313,
-0.04420938342809677,
0.019303923472762108,
0.02110755443572998,
0.01443038135766983,
0.005503181833773851,
0.00999506562948227,
-0.027759473770856857,
0.009621398523449898,
0.060602035373449326,
-0.047835830599069595,
0.03193981572985649,
-0.0... |
PMID:18381 | Qualitative changes in fibrinogen following exposure to agents used for preparation of fibrin monomers. | The solubility, clottability, thrombin clotting time and agarose gel chromatography pattern of human fibrinogen were studied after exposure to solvents commonly used to prepare fibrin monomers (0.0167 M acetic acid with 2.5 mM EDTA; 1 M NaBr, pH 5.2; 3.3 M urea, pH 7.4; 5 M urea, pH 7.4). When exposed to acetic acid at... | Qualitative changes in fibrinogen following exposure to agents used for preparation of fibrin monomers. The solubility, clottability, thrombin clotting time and agarose gel chromatography pattern of human fibrinogen were studied after exposure to solvents commonly used to prepare fibrin monomers (0.0167 M acetic acid w... | [
-0.046543776988983154,
0.003754317993298173,
0.0003023042227141559,
0.034659493714571,
0.018946092575788498,
0.031529806554317474,
0.037198103964328766,
0.04488768428564072,
-0.03860664740204811,
-0.020982451736927032,
-0.0015101770404726267,
-0.04445623606443405,
0.002536676125600934,
0.0... |
PMID:18382 | Ditazole and platelets. II. Effect of ditazole on in vivo platelet aggregation and bleeding time in rats. | Ditazole (4,5-diphenyl-2-bis-(2-hydroxyethyl)-aminoxazol) is a new drug shown to inhibit prostaglandin release from rat platelets. The present study indicates that ditazole, at doses similar to those inhibiting prostaglandin formation in rat, inhibits in vivo collagen--but not ADP-induced rat platelet aggregation. In a... | Ditazole and platelets. II. Effect of ditazole on in vivo platelet aggregation and bleeding time in rats. Ditazole (4,5-diphenyl-2-bis-(2-hydroxyethyl)-aminoxazol) is a new drug shown to inhibit prostaglandin release from rat platelets. The present study indicates that ditazole, at doses similar to those inhibiting pro... | [
-0.06389501690864563,
0.013783792965114117,
-0.01126423105597496,
0.013715994544327259,
-0.0044076102785766125,
0.03964804857969284,
0.01569744572043419,
0.08161669224500656,
-0.06662608683109283,
-0.08745995908975601,
0.06076304614543915,
-0.01267371978610754,
0.037016261368989944,
0.0952... |
PMID:18383 | Reduction of nitro-BT by some components of the chloroform-methanol extract of the grey matter of the rat brain. | An attempt was made to extract the substance present in the nerve fibres of the cerebral cortex and basal ganglia which reduced Nitro-BT in alkaline medium pH 9-5 [4,5]. The investigations were performed on 40 white Wistar rats of both sexes and ca. 200 g of body weight. The brains taken for studies were fixed in Baker... | Reduction of nitro-BT by some components of the chloroform-methanol extract of the grey matter of the rat brain. An attempt was made to extract the substance present in the nerve fibres of the cerebral cortex and basal ganglia which reduced Nitro-BT in alkaline medium pH 9-5 [4,5]. The investigations were performed on ... | [
-0.025988221168518066,
0.021670300513505936,
-0.005130046512931585,
-0.03446109965443611,
0.020717598497867584,
0.006337638478726149,
0.06178443506360054,
0.013341904617846012,
-0.046847108751535416,
-0.010948220267891884,
-0.0026216802652925253,
-0.09088975191116333,
-0.0043827746994793415,... |
PMID:18384 | [Simple on-line digital determination of the cardiac action potential and its application]. | A system of digital measuring of the cardiac action potential was constructed in order to measure quickly and accurately the resting potential or maximum diastolic potential, overshoot potential, amplitude, time for 50% repolarization and time for 90% repolarization. This system consists of a dual-beam oscilloscope, a ... | [Simple on-line digital determination of the cardiac action potential and its application]. A system of digital measuring of the cardiac action potential was constructed in order to measure quickly and accurately the resting potential or maximum diastolic potential, overshoot potential, amplitude, time for 50% repolari... | [
-0.1067628264427185,
0.005878291558474302,
0.025293486192822456,
0.0011913197813555598,
-0.05836527422070503,
-0.03164874389767647,
0.014259022660553455,
0.04674380272626877,
-0.003389638615772128,
-0.05320604145526886,
-0.003942021168768406,
-0.0828600525856018,
-0.024876192212104797,
-0.... |
PMID:18385 | Phosphate uptake and involvement of binding protein in Tween-80 supplemented culture of Aspergillus fumigatus. | Tween-80 supplementation in submerged culture of Aspergillus fumigatus resulted in an increase of phosphate uptake. The uptake system was characterized as saturable, energy-dependent and operating against the concentration gradient. Control and Tween 80 cultures showed similar Km values for phosphate uptake (50 microme... | Phosphate uptake and involvement of binding protein in Tween-80 supplemented culture of Aspergillus fumigatus. Tween-80 supplementation in submerged culture of Aspergillus fumigatus resulted in an increase of phosphate uptake. The uptake system was characterized as saturable, energy-dependent and operating against the ... | [
-0.06905857473611832,
0.05028930678963661,
0.0207700002938509,
-0.030701884999871254,
0.05058010667562485,
-0.04527696222066879,
0.07894450426101685,
0.07696380466222763,
-0.12303755432367325,
0.004367283545434475,
0.029632339254021645,
-0.10230360925197601,
0.009256180375814438,
0.0101611... |
PMID:18386 | Variation in age at puberty in monkeys. | 5 female and 3 male patas monkeys and 6 female and 3 male talapoin monkeys matured in a captive breeding colony. Age at puberty is given, and some variation discussed. The talapoin, a very small monkey, becomes adult at 4 1/2 years for females, 1 or 2 years later for males. The patas, a rather large monkey, becomes adu... | Variation in age at puberty in monkeys. 5 female and 3 male patas monkeys and 6 female and 3 male talapoin monkeys matured in a captive breeding colony. Age at puberty is given, and some variation discussed. The talapoin, a very small monkey, becomes adult at 4 1/2 years for females, 1 or 2 years later for males. The p... | [
-0.01064243819564581,
0.02629920095205307,
0.016309846192598343,
-0.008289995603263378,
0.02523776888847351,
0.029887549579143524,
0.0003515600983519107,
0.01798643171787262,
-0.0012724149273708463,
0.006593600381165743,
0.07006478309631348,
-0.08687072992324829,
0.06561489403247833,
0.003... |
PMID:18388 | [Acupuncture analgesia]. | The possibility of abolishing pain during operations by needling acupuncture points was detected in China 20 years ago. During the last years the Western World showed great interest in this method, which was tested in a great number of surgical operations. Acupuncture was successful, especially when it was introduced b... | [Acupuncture analgesia]. The possibility of abolishing pain during operations by needling acupuncture points was detected in China 20 years ago. During the last years the Western World showed great interest in this method, which was tested in a great number of surgical operations. Acupuncture was successful, especially... | [
-0.02038470096886158,
0.0019899550825357437,
0.0006680639344267547,
0.06110914796590805,
-0.00798531249165535,
0.028077490627765656,
0.08969611674547195,
0.030917448922991753,
-0.007014202885329723,
-0.002974230330437422,
-0.008271140046417713,
0.0262618288397789,
-0.01741010695695877,
0.0... |
PMID:18389 | [Treatment of concommitant depression in neurologic diseases with dibenzepin infusions]. | A definition of concommitant depression is given. The results of infusorial therapy of Dibenzepin in 53 patients with neurological diseases and concommitant depression are reported. In 86% of all cases good or very good results could be obtained. The preparation is excellently suited for this therapy. The necessity of ... | [Treatment of concommitant depression in neurologic diseases with dibenzepin infusions]. A definition of concommitant depression is given. The results of infusorial therapy of Dibenzepin in 53 patients with neurological diseases and concommitant depression are reported. In 86% of all cases good or very good results cou... | [
-0.025081034749746323,
0.007478190120309591,
-0.0010817493312060833,
0.02466106042265892,
-0.027138620615005493,
0.0009680110961198807,
0.06833115965127945,
0.04065636172890663,
-0.0062490832060575485,
-0.07172764837741852,
0.057907264679670334,
-0.053598858416080475,
0.016230691224336624,
... |
PMID:18390 | [Blood picture in lactate acidosis. Part 2: acid-base equilibrium and lactate]. | A differentiation between lactate emia (lactic acid emia) and lactate acidosis (lactic acidosis) is made. The normal value for blood lactate concentration is 1-2 mmol/1. The term lactate emia is used for lactate values between 2-6 mmol/1. The limiting value for the diagnosis of lactate acidosis should be more than 7-8 ... | [Blood picture in lactate acidosis. Part 2: acid-base equilibrium and lactate]. A differentiation between lactate emia (lactic acid emia) and lactate acidosis (lactic acidosis) is made. The normal value for blood lactate concentration is 1-2 mmol/1. The term lactate emia is used for lactate values between 2-6 mmol/1. T... | [
-0.020108235999941826,
0.02556152082979679,
0.042668666690588,
0.03588851913809776,
-0.021569455042481422,
-0.052336618304252625,
0.09964713454246521,
0.07725746929645538,
-0.004230273887515068,
0.006454036571085453,
0.0016020669136196375,
-0.10630711913108826,
-0.012990128248929977,
0.096... |
PMID:18391 | [The disease entity of lactate acidosis. 3. Lactate as a metabolic product]. | High blood lactate concentrations can be achieved by means of intravenous bicarbonate infusion. Metabolic production of lactic acid in this case is a compensation mechanism for the alcalosis induced by bicarbonate. This metabolic condition is called lactate alcalosis. The meaning and the diagnostic value of the lactate... | [The disease entity of lactate acidosis. 3. Lactate as a metabolic product]. High blood lactate concentrations can be achieved by means of intravenous bicarbonate infusion. Metabolic production of lactic acid in this case is a compensation mechanism for the alcalosis induced by bicarbonate. This metabolic condition is ... | [
0.01800461672246456,
0.003650903468951583,
0.02633516676723957,
0.025450507178902626,
-0.00005375557884690352,
-0.04781434312462807,
0.05117641016840935,
0.06000695005059242,
-0.039741937071084976,
-0.023115189746022224,
0.03641114756464958,
-0.0936458483338356,
-0.01639622077345848,
0.076... |
PMID:18392 | Disparity between insulin and proinsulin on stimulation of hepatic tyrosine transaminase. | The ability of insulin and proinsulin to stimulate tyrosine transaminase in dexamethasone-treated cultured rat liver cells was compared. Insulin increased this enzyme whereas proinsulin was seemingly without effect. Since proinsulin was not degraded by these cells, failure of stimulation of hepatic tyrosine transaminas... | Disparity between insulin and proinsulin on stimulation of hepatic tyrosine transaminase. The ability of insulin and proinsulin to stimulate tyrosine transaminase in dexamethasone-treated cultured rat liver cells was compared. Insulin increased this enzyme whereas proinsulin was seemingly without effect. Since proinsul... | [
0.0041640205308794975,
0.004534044768661261,
-0.005712567362934351,
0.023258250206708908,
0.023567497730255127,
-0.01658480428159237,
0.07172239571809769,
0.027036001905798912,
-0.038173336535692215,
-0.0016056204913184047,
-0.01990748569369316,
-0.07172351330518723,
0.0008597322157584131,
... |
PMID:18393 | Iodotyrosine deiodination in the normal and acutely TSH-stimulated thyroid. | The deiodination of L-MIT-125I was measured in rat thyroid homogenates and slices before and after acute TSH stimulation. Slices and homogenates were incubated with identical concentrations of tissue and substrate in the presence and absence of NADPH. 1 USP unit TSH added in vitro to thyroid slices failed to stimulate ... | Iodotyrosine deiodination in the normal and acutely TSH-stimulated thyroid. The deiodination of L-MIT-125I was measured in rat thyroid homogenates and slices before and after acute TSH stimulation. Slices and homogenates were incubated with identical concentrations of tissue and substrate in the presence and absence of... | [
-0.01559341698884964,
-0.031089890748262405,
0.04118262976408005,
0.020319288596510887,
-0.0053760092705488205,
-0.028269458562135696,
0.08259511739015579,
0.04699847102165222,
-0.03433883190155029,
-0.022329412400722504,
0.028436021879315376,
-0.08523840457201004,
-0.027434678748250008,
0... |
PMID:18395 | Specific, water-soluble polypeptides in identified neurons of Aplysia californica. | Application of an ethylene glycol lysis technique to extract water-soluble, low molecular weight polypeptides in Aplysia neurons, was used in conjunction with microgradient gel electrophoresis and micro-isoelectric focusing, to identify unique polypeptides in specific, identified neurons. The polypeptides found in neur... | Specific, water-soluble polypeptides in identified neurons of Aplysia californica. Application of an ethylene glycol lysis technique to extract water-soluble, low molecular weight polypeptides in Aplysia neurons, was used in conjunction with microgradient gel electrophoresis and micro-isoelectric focusing, to identify ... | [
-0.03861803933978081,
-0.061272479593753815,
0.032642561942338943,
-0.057575758546590805,
-0.03631167113780975,
-0.014661462046205997,
0.07060656696557999,
0.01705387607216835,
-0.0290627870708704,
0.014581949450075626,
0.019636662676930428,
-0.05585440248250961,
-0.016444390639662743,
0.0... |
PMID:18396 | Distribution of beta-N-acetylglucosaminidase, hyaluronoglucosaminidase and acrosin in buffalo and goat spermatozoa. | The distribution of beta-N-acetylglucosaminidase, hyaluronoglucosaminidase and acrosin in buffalo and goat sperm acrosomes was studied. The three hydrolases were found to occur in soluble and bound forms. In the bound form, they were associated with the denuded sperm and were maximally solubilized at pH 3.0. The possib... | Distribution of beta-N-acetylglucosaminidase, hyaluronoglucosaminidase and acrosin in buffalo and goat spermatozoa. The distribution of beta-N-acetylglucosaminidase, hyaluronoglucosaminidase and acrosin in buffalo and goat sperm acrosomes was studied. The three hydrolases were found to occur in soluble and bound forms.... | [
-0.005128342192620039,
0.03005463443696499,
-0.055034566670656204,
-0.020978407934308052,
0.011674551293253899,
0.039836522191762924,
0.015583992935717106,
0.04337342828512192,
-0.018187541514635086,
-0.006933142896741629,
-0.002367908600717783,
-0.09497810900211334,
-0.0029115222860127687,
... |
PMID:18397 | [Purification and properties of the tetrahydropteroylglutamate methyltransferase from green beans (Phaseolus vulgaris) (author's transl)]. | The tetrahydropteroylglutamate methyltransferase from green beans (Phaseolus vulgaris) has been purified 80-fold by ion exchange chromatography and gel filtration. Optimal methyl transfer is found at pH 6.5 and 39 degrees C. Even at 0 degrees C, however, a considerable catalytic rate is observed. The Michaelis-Menten c... | [Purification and properties of the tetrahydropteroylglutamate methyltransferase from green beans (Phaseolus vulgaris) (author's transl)]. The tetrahydropteroylglutamate methyltransferase from green beans (Phaseolus vulgaris) has been purified 80-fold by ion exchange chromatography and gel filtration. Optimal methyl tr... | [
-0.018984541296958923,
0.015926644206047058,
-0.06596441566944122,
-0.02648353949189186,
0.0070308721624314785,
-0.031160999089479446,
0.015158673748373985,
0.03139417618513107,
-0.03212520107626915,
-0.003746043425053358,
-0.013683878816664219,
-0.0841766968369484,
0.03547338396310806,
-0... |
PMID:18400 | Induction of placental alkaline phosphatase in choriocarcinoma cells by 5-bromo-2'-deoxyuridine. | Growth of choriocarcinoma cells in the presence of 5-bromo-2'-deoxyuridine (BrdUrd) results in a 30- to 40-fold increase in alkaline phosphatase activity. The effects of BrdUrd is specific for phosphatase with an alkaline pH optimum. The induction by BrdUrd is probably not due to the production of an altered enzyme, si... | Induction of placental alkaline phosphatase in choriocarcinoma cells by 5-bromo-2'-deoxyuridine. Growth of choriocarcinoma cells in the presence of 5-bromo-2'-deoxyuridine (BrdUrd) results in a 30- to 40-fold increase in alkaline phosphatase activity. The effects of BrdUrd is specific for phosphatase with an alkaline p... | [
-0.03508971631526947,
0.0228012315928936,
0.00784806627780199,
0.049848686903715134,
0.0016918312758207321,
0.003412401769310236,
0.032547444105148315,
0.049097348004579544,
-0.06104987487196922,
-0.04198087751865387,
0.017762014642357826,
-0.0646170973777771,
-0.01285204105079174,
-0.0045... |
PMID:18403 | Effects of trypan blue treatment on the immune responses of mice. | It has been reported that trypan blue treatment decreases the nonspecific resistance of mice to transplanted tumors and inhibits the in vitro cytotoxic activity of activated macrophages. We wished to determine whether this effect of trypan blue could be due to a selective inhibition of certain macrophage functions or w... | Effects of trypan blue treatment on the immune responses of mice. It has been reported that trypan blue treatment decreases the nonspecific resistance of mice to transplanted tumors and inhibits the in vitro cytotoxic activity of activated macrophages. We wished to determine whether this effect of trypan blue could be ... | [
-0.035693056881427765,
-0.024616073817014694,
0.01112922839820385,
-0.000027075220714323223,
0.016379470005631447,
-0.002684892388060689,
0.10657447576522827,
0.08654135465621948,
-0.08281916379928589,
-0.04577593132853508,
0.025755032896995544,
-0.019619783386588097,
-0.017437143251299858,
... |
PMID:18404 | Lung bacterial clearance in murine pneumococcal pneumonia. | We studied the bactericidal capacity of the rat lung during the development of pneumococcal pneumonia. Pneumonia was produced in a lower lobe by the intrabronchial instillation of 10(4)Streptococcus pneumoniae cells in buffer. Lung bacterial counts progressively increased, reaching 10(7) per lung within 48 h, and the i... | Lung bacterial clearance in murine pneumococcal pneumonia. We studied the bactericidal capacity of the rat lung during the development of pneumococcal pneumonia. Pneumonia was produced in a lower lobe by the intrabronchial instillation of 10(4)Streptococcus pneumoniae cells in buffer. Lung bacterial counts progressivel... | [
-0.0198700949549675,
0.03682824969291687,
0.005022903438657522,
-0.028728164732456207,
0.0316886231303215,
0.0034442569594830275,
0.04753708839416504,
0.014914270490407944,
-0.023551952093839645,
0.03204146400094032,
0.008222497999668121,
-0.0982726588845253,
0.03507078438997269,
-0.002361... |
PMID:18405 | Mild alkaline hydrolysis of lipopolysaccharide endotoxin enhances its mitogencity for murine B cells. | Mild alkaline hydrolysis was found to enhance the mitogenicity of lipopolysaccharide endotoxin for murine B lymphocytes. Alkaline treated lipopolysaccharide also retained its property as a polyclonal activator. Whereas this treatment reduced the lethality of endotoxin for mice, its toxicity for lymphocytes cultured in ... | Mild alkaline hydrolysis of lipopolysaccharide endotoxin enhances its mitogencity for murine B cells. Mild alkaline hydrolysis was found to enhance the mitogenicity of lipopolysaccharide endotoxin for murine B lymphocytes. Alkaline treated lipopolysaccharide also retained its property as a polyclonal activator. Whereas... | [
-0.06202374026179314,
-0.0010973329190164804,
0.007255275268107653,
-0.000628155714366585,
-0.05715556442737579,
-0.04155908524990082,
0.02729645185172558,
0.06729193776845932,
-0.0652397945523262,
-0.01764996163547039,
-0.0116895055398345,
-0.06378154456615448,
0.009731912054121494,
-0.01... |
PMID:18402 | Effect of some antihistaminic drugs on the oestrous cycyle of rats. | The effect of some antihistaminic drugs namely antazoline hydrochloride, diphenhy, dramine hydrochloride and mepyramine maleate has been investigated on the oestrous cycle in albino rats. On daily intraperitoneal administration, for 6 days, all the three drugs (10 mg/kg) significantly (P less than 0.001) prolonged the ... | Effect of some antihistaminic drugs on the oestrous cycyle of rats. The effect of some antihistaminic drugs namely antazoline hydrochloride, diphenhy, dramine hydrochloride and mepyramine maleate has been investigated on the oestrous cycle in albino rats. On daily intraperitoneal administration, for 6 days, all the thr... | [
-0.0044807628728449345,
0.008377362973988056,
-0.0019150590524077415,
0.02654348872601986,
-0.019130047410726547,
0.00048627384239807725,
0.06931589543819427,
0.035063453018665314,
-0.07086264342069626,
-0.05492855980992317,
0.026644878089427948,
-0.03033430688083172,
0.035118233412504196,
... |
PMID:18406 | [Assay of aminoglycosides in serum using the urease method (author's transl)]. | The urease method developed by Noone et al. for rapid bioassay of aminoglycoside antibiotics in serum is described in detail. The accuracy of the method was improved by using a BM 1-09 electrode assembly (Metrohm, CH-9100 Herisau, Switzerland) in conjunction with a digital pH-Meter (Metrohm E 500). The mean difference ... | [Assay of aminoglycosides in serum using the urease method (author's transl)]. The urease method developed by Noone et al. for rapid bioassay of aminoglycoside antibiotics in serum is described in detail. The accuracy of the method was improved by using a BM 1-09 electrode assembly (Metrohm, CH-9100 Herisau, Switzerlan... | [
-0.047067806124687195,
0.05791806802153587,
0.05136091262102127,
0.01563025824725628,
0.04896124452352524,
-0.017168454825878143,
0.0036572241224348545,
0.04662007465958595,
-0.04858020320534706,
-0.037479374557733536,
0.036050863564014435,
-0.04879819229245186,
0.06616497039794922,
0.0209... |
PMID:18407 | Circulating prolactin levels. I. Normal females. | A specific, homologous radioimmunoassay was used to quantitate circulating levels of prolactin in females in various stages of life. They were grouped in periods of newborns to peripubertal females, reproductive, gravid and puerperal, and postmenopausal females. The results reveal dynamic changes of prolactin throughou... | Circulating prolactin levels. I. Normal females. A specific, homologous radioimmunoassay was used to quantitate circulating levels of prolactin in females in various stages of life. They were grouped in periods of newborns to peripubertal females, reproductive, gravid and puerperal, and postmenopausal females. The resu... | [
0.000996254151687026,
-0.0014928795862942934,
-0.011485863476991653,
0.007659167982637882,
-0.0026779090985655785,
0.04249457269906998,
0.03461311757564545,
0.041839599609375,
-0.025389017537236214,
-0.052818428725004196,
0.033744633197784424,
-0.05550036206841469,
-0.008702419698238373,
0... |
PMID:18408 | Follicular development during late human pregnancy. | In contrast to the accepted view of ovarian quiescence during pregnancy, the ovaries of preparturient women are covered with a dense population of small superficial follicles. In this study we have measured the follicular size and status of the oocytes and cumulus oophorus in 298 follicles from the ovaries of 30 women.... | Follicular development during late human pregnancy. In contrast to the accepted view of ovarian quiescence during pregnancy, the ovaries of preparturient women are covered with a dense population of small superficial follicles. In this study we have measured the follicular size and status of the oocytes and cumulus oop... | [
0.03236926347017288,
-0.018979305401444435,
0.010394376702606678,
0.024973606690764427,
0.028185483068227768,
0.01525186188519001,
0.01590147614479065,
0.05828465521335602,
-0.023485954850912094,
-0.020538117736577988,
0.005953113082796335,
-0.0825083926320076,
-0.0339941680431366,
0.04916... |
PMID:18409 | Successful separation of X and Y and spermatozoa in human and bull semen. | Using particle free semen extender and applying a low temperature thermal convection laminar flow to bring the sperm cells in vertical orientation and allowing them to act through the center of buoyancy, a bimodal distribution was achieved. Laser scanner for observing sedimentation pattern and F-body technique for iden... | Successful separation of X and Y and spermatozoa in human and bull semen. Using particle free semen extender and applying a low temperature thermal convection laminar flow to bring the sperm cells in vertical orientation and allowing them to act through the center of buoyancy, a bimodal distribution was achieved. Laser... | [
0.02414674498140812,
0.05634596571326256,
-0.004905194975435734,
-0.033249564468860626,
0.01438623946160078,
0.03609008342027664,
0.025764228776097298,
0.034417524933815,
0.023771878331899643,
0.021424641832709312,
-0.021434355527162552,
-0.10698128491640091,
0.017522789537906647,
-0.00913... |
PMID:18410 | Autoradiographic studies of rabbit ova after fertilization with thymidine-H3 and -C14 labelled spermatozoa originating from different bucks. | Rabbit spermatozoa were labelled in vivo injecting male rabbits with thymidine-H3 and thymidine-C14. Ova fertilized with H3-labelled spermatozoa were found to contain more silver grains when they had cleaved several times than before cleavage. Fertilized ova originating from rabbits that had been mated with both an H3-... | Autoradiographic studies of rabbit ova after fertilization with thymidine-H3 and -C14 labelled spermatozoa originating from different bucks. Rabbit spermatozoa were labelled in vivo injecting male rabbits with thymidine-H3 and thymidine-C14. Ova fertilized with H3-labelled spermatozoa were found to contain more silver ... | [
0.026212327182292938,
-0.02847367152571678,
-0.049304962158203125,
0.007505926303565502,
0.039571765810251236,
0.027567537501454353,
0.015642475336790085,
0.06418443471193314,
-0.05327178165316582,
0.01650877110660076,
0.013484521768987179,
-0.10718999058008194,
-0.022119343280792236,
0.01... |
PMID:18411 | Absence of a prenidatory effect of luteinizing hormone releasing hormone (LHRH) in hamsters. | Luteinizing hormone releasing hormone at high doses will terminate gestation in rats during early and midpregancy (ED50 approximately equal to 100 microgram/day) and rabbits during early pregnancy. Early pregnancy in hamsters, in contradistinction, seems refractory to this effect. Administration of LHRH up to massive d... | Absence of a prenidatory effect of luteinizing hormone releasing hormone (LHRH) in hamsters. Luteinizing hormone releasing hormone at high doses will terminate gestation in rats during early and midpregancy (ED50 approximately equal to 100 microgram/day) and rabbits during early pregnancy. Early pregnancy in hamsters, ... | [
0.00497616920620203,
0.018073489889502525,
-0.0431787371635437,
0.031023059040308,
0.03163053095340729,
0.0043085673823952675,
0.03390679880976677,
0.0048124296590685844,
-0.05477862060070038,
-0.03792201355099678,
0.014122646301984787,
0.02680000476539135,
-0.009286973625421524,
0.0493744... |
PMID:18412 | The role of prostaglandins on the increase in motility of the rat-uterine horn containing a silk suture. | The presence of a silk suture in one uterine horn of the rats leads to an increase in spontaneous motility when compared with the contralateral control horn. Indomethacin, an inhibitor of prostaglandin synthetase inhibits the motility suggesting a role of prostaglandins in this process. | The role of prostaglandins on the increase in motility of the rat-uterine horn containing a silk suture. The presence of a silk suture in one uterine horn of the rats leads to an increase in spontaneous motility when compared with the contralateral control horn. Indomethacin, an inhibitor of prostaglandin synthetase in... | [
-0.02466493658721447,
-0.0326254665851593,
-0.03307079151272774,
-0.006440640427172184,
-0.008578434586524963,
0.03146102651953697,
0.030441580340266228,
0.015252201817929745,
-0.04328025504946709,
-0.022904448211193085,
0.08128626644611359,
-0.04042681306600571,
0.0321834459900856,
0.0301... |
PMID:18413 | Paper chromatographic estimation of fructose and myo-inositol in human seminal fluid: a method for evaluating seminal vesicle and prostatic function. | A semiquantitative paper chromatographic method for the separation of myo-inositol and fructose in human seminal fluid was described. The intensity of the chromatographic zones characteristic of myo-inositol, which is a marker for human prostatic secretion and for fructose, which is useful in evaluating seminal vesicle... | Paper chromatographic estimation of fructose and myo-inositol in human seminal fluid: a method for evaluating seminal vesicle and prostatic function. A semiquantitative paper chromatographic method for the separation of myo-inositol and fructose in human seminal fluid was described. The intensity of the chromatographic... | [
-0.004124626982957125,
-0.03779701516032219,
0.04339786618947983,
-0.028028002008795738,
0.029319874942302704,
0.00871647521853447,
0.05541691929101944,
0.057982705533504486,
-0.017238745465874672,
-0.025719963014125824,
-0.0016332175582647324,
-0.07668579369783401,
-0.004280401859432459,
... |
PMID:18414 | Gonadal function following vasectomy in the rat. | Adult rats were studied at four, eight, and 12 months following vasectomy and sham-operation. The weights of the seminal vesicles, ventral prostate, pituitary, and kidneys were not significantly affected by vasectomy. Testicular endocrine function in vasectotomized rat was transiently stimulated as witnessed by elevati... | Gonadal function following vasectomy in the rat. Adult rats were studied at four, eight, and 12 months following vasectomy and sham-operation. The weights of the seminal vesicles, ventral prostate, pituitary, and kidneys were not significantly affected by vasectomy. Testicular endocrine function in vasectotomized rat w... | [
0.02820720337331295,
0.028993571177124977,
0.08279704302549362,
-0.06962206214666367,
0.0030318372882902622,
0.038759928196668625,
0.08824959397315979,
0.011723242700099945,
-0.07593106478452682,
-0.011129352264106274,
0.01755555532872677,
-0.0264615286141634,
0.07531576603651047,
0.051555... |
PMID:18415 | Testosterone production and metabolism in laboratory-maintained male rhesus monkeys. | Plasma production rates (PR), metabolic clearance rates (MCR) and plasma levels of testosterone were determined in 10 male, laboratory-maintained rhesus monkeys on two occasions out-of-season (April and August) and once in-season (October). Plasma testosterone levels in October were higher than those in April and Augus... | Testosterone production and metabolism in laboratory-maintained male rhesus monkeys. Plasma production rates (PR), metabolic clearance rates (MCR) and plasma levels of testosterone were determined in 10 male, laboratory-maintained rhesus monkeys on two occasions out-of-season (April and August) and once in-season (Octo... | [
0.016077907755970955,
0.07704845815896988,
0.033194877207279205,
0.018744461238384247,
0.08004794269800186,
0.025058595463633537,
0.04664188250899315,
0.008714736439287663,
-0.02963484637439251,
-0.02908591739833355,
0.04107169434428215,
-0.05977928265929222,
0.03587952256202698,
0.0406162... |
PMID:18416 | Pituitary and ovarian response to acute stimulation with LH-RH in normal and anovulatory women. | The LH FSH estradiol and progesterone responses to acute stimulation with LH-RH were studied in 12 normal women with ovulatory cycles (4 in the initial follicular phase, 4 in the mid-follicular phase and 4 in the late follicular phase) and in two castrated women, two under hormonal contraception, two with ovarian ameno... | Pituitary and ovarian response to acute stimulation with LH-RH in normal and anovulatory women. The LH FSH estradiol and progesterone responses to acute stimulation with LH-RH were studied in 12 normal women with ovulatory cycles (4 in the initial follicular phase, 4 in the mid-follicular phase and 4 in the late follic... | [
0.02636312134563923,
0.0033140480518341064,
-0.02040652371942997,
0.05252711847424507,
0.03712616115808487,
-0.02658124454319477,
0.022224493324756622,
0.025058655068278313,
-0.024259569123387337,
-0.03527342155575752,
0.0076558394357562065,
-0.038670361042022705,
-0.005302689503878355,
0.... |
PMID:18417 | Seminal fructose and acid phosphatase in vasectomised men. | Seminal fructose and acid phosphatase levels have been determined in 30 vasectomised and 30 nonvasectomised healthy adults, both the groups being closely matched for age (32 to 45 years). The fructose and acid phosphatase values in the vasectomised men, 3 to 6 months after the operation, were 316 +/- 36 mg% and 2,098 +... | Seminal fructose and acid phosphatase in vasectomised men. Seminal fructose and acid phosphatase levels have been determined in 30 vasectomised and 30 nonvasectomised healthy adults, both the groups being closely matched for age (32 to 45 years). The fructose and acid phosphatase values in the vasectomised men, 3 to 6 ... | [
0.016787471249699593,
0.02995339035987854,
0.001630983198992908,
-0.023356253281235695,
0.027060413733124733,
0.00348983914591372,
0.06856178492307663,
0.07299444824457169,
-0.024571584537625313,
-0.03749103471636772,
0.03050510212779045,
-0.08934575319290161,
0.006229588761925697,
0.01980... |
PMID:18418 | The 'in vivo' effects of oxytocin and vasopressin on spontaneous contractility of the rat epididymis. | The spontaneous contractility of the epididymis in the rat was recorded in vivo and the effects of the neurohypophyseal hormones were studied. Oxytocin (50 muU and 500 muU/100 g body weight) produced a progressive increase in tonus together with an increase in amplitude and frequency of the contractions. Vasopressin (1... | The 'in vivo' effects of oxytocin and vasopressin on spontaneous contractility of the rat epididymis. The spontaneous contractility of the epididymis in the rat was recorded in vivo and the effects of the neurohypophyseal hormones were studied. Oxytocin (50 muU and 500 muU/100 g body weight) produced a progressive incr... | [
-0.0648789331316948,
-0.07120739668607712,
0.0666758343577385,
-0.00010260607086820528,
0.02903570607304573,
0.02366284467279911,
0.04282030835747719,
0.00888042338192463,
-0.03817947208881378,
-0.03313424810767174,
-0.027813924476504326,
-0.0248861201107502,
0.004813647363334894,
0.059052... |
PMID:18420 | Interpretation of thermal perturbation spectra of proteins. | The thermal perturbation difference spectrum of reduced lysozyme has a long wave length extremum at 304 nm at pH 6.15 and a very small extremum at 306 nm at pH 1.5. These results differ from those of Leach & Smith (1972), which showed an extremum at 293 nm, the same as for model tryptophyl compounds. Our result may... | Interpretation of thermal perturbation spectra of proteins. The thermal perturbation difference spectrum of reduced lysozyme has a long wave length extremum at 304 nm at pH 6.15 and a very small extremum at 306 nm at pH 1.5. These results differ from those of Leach & Smith (1972), which showed an extremum at 293 nm... | [
-0.0831819623708725,
0.011266915127635002,
0.04087817668914795,
0.002190515398979187,
0.03504825383424759,
-0.03264537826180458,
0.08003494888544083,
0.03157052770256996,
-0.011618551798164845,
-0.04567793384194374,
0.019158292561769485,
-0.05954491347074509,
0.0055013662204146385,
0.04998... |
PMID:18421 | Stabilisation of enzyme structures by inhibitors. A nuclear magnetic resonance study of the effect of phosphate on the acid unfolding of ribonuclease A. | The acid denaturation of bovine pancreatic ribonuclease A in the presence of 0.2M sodium dihydrogen phosphate has been studied by n.m.r. spectroscopy. Phenylalanine, tyrosine and methionine resonances serve as monitors of the unfolding process. It is shown that the inhibitor shifts the equilibrium towards the native st... | Stabilisation of enzyme structures by inhibitors. A nuclear magnetic resonance study of the effect of phosphate on the acid unfolding of ribonuclease A. The acid denaturation of bovine pancreatic ribonuclease A in the presence of 0.2M sodium dihydrogen phosphate has been studied by n.m.r. spectroscopy. Phenylalanine, t... | [
-0.08773904293775558,
0.005781390238553286,
-0.040687333792448044,
0.022353962063789368,
-0.006269028410315514,
-0.029273131862282753,
0.04600394889712334,
0.02320209890604019,
-0.048026151955127716,
-0.01209320593625307,
0.010621145367622375,
-0.0930166095495224,
0.03170762583613396,
-0.0... |
PMID:18422 | Levels of neurotransmitters in brain of vitamin B12 deficient rats. | The levels of norepinephrine, dopamine and 5-hydroxytryptamine in brain homogenates of vitamin B12-deficient rats have been investigated. The norepinephrine levels were significantly decreased in the deficient animals compared to controls. The two major catabolic pathways of norepinephrine e.g. monoamine oxidase and ca... | Levels of neurotransmitters in brain of vitamin B12 deficient rats. The levels of norepinephrine, dopamine and 5-hydroxytryptamine in brain homogenates of vitamin B12-deficient rats have been investigated. The norepinephrine levels were significantly decreased in the deficient animals compared to controls. The two majo... | [
-0.0188908651471138,
0.000592649623285979,
-0.051713891327381134,
0.009794839657843113,
-0.038811758160591125,
0.016751190647482872,
0.06857471168041229,
0.06524159759283066,
-0.02813984639942646,
-0.04732267186045647,
0.01143613364547491,
-0.06091157719492912,
0.03866875171661377,
0.05499... |
PMID:18423 | The buccal absorption of ascorbic acid and its passage through lipoid membrane. | Ascorbic acid concentration was measured in centrifuged and uncentrifuged saliva from normal young adult men and women. The salivary ascorbic acid content of uncentrifuged saliva was significantly higher in women on account of the ascorbic acid contained in the cellular sediment. Ascorbic acid absorption into the bucca... | The buccal absorption of ascorbic acid and its passage through lipoid membrane. Ascorbic acid concentration was measured in centrifuged and uncentrifuged saliva from normal young adult men and women. The salivary ascorbic acid content of uncentrifuged saliva was significantly higher in women on account of the ascorbic ... | [
0.0031932322308421135,
0.02849600650370121,
0.018482817336916924,
0.04148808866739273,
-0.01451002899557352,
-0.030271992087364197,
0.08066337555646896,
0.0304288100451231,
0.01003496814519167,
-0.009357345290482044,
0.039796970784664154,
-0.1243659257888794,
0.06746251881122589,
-0.015802... |
PMID:18425 | Physicochemical characteristics, morphology and morphogenesis of virions of the causative agent of Crimean hemorrhagic fever. | Similar physicochemical characteristics were found with strains of Crimean hemorrhagic fever (CHF) and Congo viruses. The particle size, sedimentation coefficient, buoyant density, weight of the particles as well as morphology and morphogenesis of these viruses were similar to those of other members of the Bunyaviridae... | Physicochemical characteristics, morphology and morphogenesis of virions of the causative agent of Crimean hemorrhagic fever. Similar physicochemical characteristics were found with strains of Crimean hemorrhagic fever (CHF) and Congo viruses. The particle size, sedimentation coefficient, buoyant density, weight of the... | [
-0.023206567391753197,
-0.0326165109872818,
-0.00836775079369545,
0.05980255827307701,
0.009537111036479473,
-0.013602462597191334,
0.06495019793510437,
0.04440499097108841,
-0.043866924941539764,
-0.03181111440062523,
-0.0032712311949580908,
-0.10127735882997513,
0.03118751384317875,
0.01... |
PMID:18428 | Studies of binding C3-substitute rifamycins to human and bovine serum albumin. | The interactions of a series of C3-substituted rifamycins with human and bovine serum albumins were studied in order to find possible correlations between the degree of binding and the structural features of the various molecules. The results obtained indicate some of the physicochemical properties and, therefore, of t... | Studies of binding C3-substitute rifamycins to human and bovine serum albumin. The interactions of a series of C3-substituted rifamycins with human and bovine serum albumins were studied in order to find possible correlations between the degree of binding and the structural features of the various molecules. The result... | [
-0.03253340348601341,
-0.01777936890721321,
0.00040657032513991,
0.034716442227363586,
0.0481792688369751,
-0.02865445800125599,
0.046364203095436096,
0.009341645985841751,
-0.058522939682006836,
-0.03669134899973869,
0.0027032000944018364,
-0.0039365096017718315,
0.04933486506342888,
-0.0... |
PMID:18429 | On RNA-polymerases of leukemia L 1210 origin and an enzymatic method to screen antitumor antibiotics. | Four DNA-dependent RNA-polymerases were separated from the cell homogenate of moust leukemia L1210 cell by DEAE-cellulose column chromatography and tentatively designated as Peaks I, II, III and IV in the elution order. Peak II was inactivated by the addition of alpha-amanitin and effects of antibiotics and enzymes on ... | On RNA-polymerases of leukemia L 1210 origin and an enzymatic method to screen antitumor antibiotics. Four DNA-dependent RNA-polymerases were separated from the cell homogenate of moust leukemia L1210 cell by DEAE-cellulose column chromatography and tentatively designated as Peaks I, II, III and IV in the elution order... | [
-0.09459338337182999,
0.04486965760588646,
-0.010601073503494263,
-0.018017154186964035,
0.003509512171149254,
0.020120080560445786,
0.019125191494822502,
0.045124560594558716,
-0.019200971350073814,
0.009509004652500153,
0.028494181111454964,
0.040860604494810104,
-0.03858156502246857,
-0... |
PMID:18426 | Pig plasma benzylamine oxidase: some considerations on the mechanism of the reaction. | The kinetics of benzaldehyde formation during the oxidation of benzylamine by pig plasma benzylamine oxidase have been studied at different pH values. It has been shown that the first step of the reaction catalyzed by this enzyme is the formation of a Schiff base between the amino group of the substrate and the aldehyd... | Pig plasma benzylamine oxidase: some considerations on the mechanism of the reaction. The kinetics of benzaldehyde formation during the oxidation of benzylamine by pig plasma benzylamine oxidase have been studied at different pH values. It has been shown that the first step of the reaction catalyzed by this enzyme is t... | [
-0.09530370682477951,
0.01683337800204754,
-0.043606698513031006,
0.03632555156946182,
0.04587075859308243,
-0.03976651281118393,
-0.01208407524973154,
0.023228419944643974,
-0.045180656015872955,
0.0010982570238411427,
0.00044913633610121906,
-0.033545371145009995,
-0.000628888956271112,
... |
PMID:18436 | Oxygen consumption and ventilation of dogs during passive and active exercise. | A comparison was made between the influence of passive and active exercise on the energy metabolism (EM) and respiratory parameters (RP) of dogs: respiratory minute volume and ventilatory equivalent for O2. Passive exercise was performed in 24 dogs, anesthetized with pentobarbital sodium and morphine or ketamine hydroc... | Oxygen consumption and ventilation of dogs during passive and active exercise. A comparison was made between the influence of passive and active exercise on the energy metabolism (EM) and respiratory parameters (RP) of dogs: respiratory minute volume and ventilatory equivalent for O2. Passive exercise was performed in ... | [
-0.038796428591012955,
-0.00943983905017376,
0.04018111526966095,
0.056150369346141815,
0.022735372185707092,
0.046036701649427414,
0.03484002500772476,
0.022200332954525948,
0.010589499957859516,
0.01708526723086834,
-0.0024488905910402536,
-0.05565066263079643,
-0.0040593016892671585,
-0... |
PMID:18437 | Rate of pH changes in blood plasma in vitro and in vivo. | The rate of pH decrease in dog blood after addition of CO2 (dissolved in saline) was measured in vitro with a combination pH electrode and fast-response amplifier. The pH change was found to have an apparent half time of 6.0 +/- 0.5 s at 38 degrees C, similar to that predicted by previous mathematical simulations on th... | Rate of pH changes in blood plasma in vitro and in vivo. The rate of pH decrease in dog blood after addition of CO2 (dissolved in saline) was measured in vitro with a combination pH electrode and fast-response amplifier. The pH change was found to have an apparent half time of 6.0 +/- 0.5 s at 38 degrees C, similar to ... | [
-0.08175850659608841,
0.03654021397233009,
0.03185084089636803,
0.062349606305360794,
0.012401069514453411,
-0.018281111493706703,
0.06911049783229828,
0.04918096959590912,
0.002494445536285639,
0.03763075917959213,
0.048161402344703674,
-0.10424067080020905,
-0.03587218374013901,
0.069589... |
PMID:18438 | Urease of Klebsiella aerogenes: control of its synthesis by glutamine synthetase. | Urease was purified 24-fold from extracts of Klebsiella aerogenes. The enzyme has a molecular weight of 230,000 as determined by gel filtration, is highly substrate specific, and has a Km for urea of 0.7 mM. A mutant strain lacking urease was isolated; it failed to grow with urea as the sole source of nitrogen but did ... | Urease of Klebsiella aerogenes: control of its synthesis by glutamine synthetase. Urease was purified 24-fold from extracts of Klebsiella aerogenes. The enzyme has a molecular weight of 230,000 as determined by gel filtration, is highly substrate specific, and has a Km for urea of 0.7 mM. A mutant strain lacking urease... | [
-0.01684466190636158,
-0.006278731394559145,
0.006669339723885059,
0.019487865269184113,
0.045826394110918045,
0.00632208539173007,
-0.03318057209253311,
0.010790516622364521,
-0.057978544384241104,
0.05597004294395447,
-0.024586431682109833,
-0.08468550443649292,
0.04426661506295204,
-0.0... |
PMID:18439 | Fermentative metabolism of pyruvate by Rhodospirillum rubrum after anaerobic growth in darkness. | Rhodospirillum rubrum grew anaerobically in darkness and fermented sodium pyruvate by a pyruvate formate-lyase reaction. During 30 min of anaerobic dark or light incubation with sodium pyrivate, crude extracts from fermentatively grown cells produced about 6 micronmol of acetylphosphate and formate per mg of protein in... | Fermentative metabolism of pyruvate by Rhodospirillum rubrum after anaerobic growth in darkness. Rhodospirillum rubrum grew anaerobically in darkness and fermented sodium pyruvate by a pyruvate formate-lyase reaction. During 30 min of anaerobic dark or light incubation with sodium pyrivate, crude extracts from fermenta... | [
-0.0508296936750412,
0.011847956106066704,
-0.0768255814909935,
0.043052591383457184,
0.09516168385744095,
-0.02694472298026085,
-0.03327886760234833,
-0.011580518446862698,
-0.04461367428302765,
-0.04278348758816719,
0.039507895708084106,
-0.10247701406478882,
0.010529338382184505,
0.0080... |
PMID:18440 | Characterization of an endonuclease associated with the drug resistance plasmid pKM101. | An endonuclease was detected in strains of Salmonella typhimurium containing the drug resistance plasmid pKM101. The enzyme was not detectable in strains lacking this plasmid, but it was present in strains containing mutants of pKM101 that were no longer able to enhance host cell mutagenesis. The endonuclease had a mol... | Characterization of an endonuclease associated with the drug resistance plasmid pKM101. An endonuclease was detected in strains of Salmonella typhimurium containing the drug resistance plasmid pKM101. The enzyme was not detectable in strains lacking this plasmid, but it was present in strains containing mutants of pKM1... | [
-0.04446089640259743,
-0.03856687620282173,
-0.039119839668273926,
-0.018158286809921265,
0.00875375047326088,
-0.028449544683098793,
0.02061484009027481,
0.08088566362857819,
-0.06698918342590332,
0.021581832319498062,
0.050162822008132935,
-0.05861057713627815,
0.026711376383900642,
-0.0... |
PMID:18441 | Enzymatic reduction of mercurous ions in Escherichia coli bearing R factor. | Mercurous ion (Hg(+))-dependent reduced nicotinamide adenine dinucleotide phosphate oxidation was demonstrated in an extract from cells of Escherichia coli W2252 that bear R factor. | Enzymatic reduction of mercurous ions in Escherichia coli bearing R factor. Mercurous ion (Hg(+))-dependent reduced nicotinamide adenine dinucleotide phosphate oxidation was demonstrated in an extract from cells of Escherichia coli W2252 that bear R factor. | [
-0.10585669428110123,
0.06531891971826553,
-0.06159968301653862,
0.02144472859799862,
0.10152330994606018,
-0.014927414245903492,
0.03989368677139282,
0.06845594197511673,
-0.03295601159334183,
0.033080875873565674,
-0.02679687738418579,
-0.0561073012650013,
0.05029037222266197,
0.00593197... |
PMID:18446 | Base specificity of polyamine binding to synthetic polynucleotides. | The binding of polyamines and magnesium to synthetic polynucleotides has been studied by gel filtration on a Sephadex G-50 column. Among the single-stranded polynucleotides examined [poly(A), poly(C), and poly(U)], polyamines were found to bind to poly(C) and poly(U) preferentially, while the binding of Mg2+ was greate... | Base specificity of polyamine binding to synthetic polynucleotides. The binding of polyamines and magnesium to synthetic polynucleotides has been studied by gel filtration on a Sephadex G-50 column. Among the single-stranded polynucleotides examined [poly(A), poly(C), and poly(U)], polyamines were found to bind to poly... | [
-0.06523500382900238,
0.04475608468055725,
-0.0040007103234529495,
-0.032232433557510376,
0.017220735549926758,
0.04778926819562912,
0.061426687985658646,
0.018883198499679565,
-0.055473629385232925,
0.0274930689483881,
0.03900940716266632,
-0.02991795726120472,
0.055892009288072586,
0.001... |
PMID:18447 | Morphology of lipid micelles containing lysolecithin. | Mixtures of lysolecithin with various phospholipids were studied by electron microscopy using negative staining. Mixtures of dipalmitoyllecithin and lysolecithin produced disc-shaped structures which were stacked in aggregates with a 6.0--6.4 nm repeat. The disc were 10--50 nm in diameter. The disc-shaped structures we... | Morphology of lipid micelles containing lysolecithin. Mixtures of lysolecithin with various phospholipids were studied by electron microscopy using negative staining. Mixtures of dipalmitoyllecithin and lysolecithin produced disc-shaped structures which were stacked in aggregates with a 6.0--6.4 nm repeat. The disc wer... | [
-0.016399269923567772,
-0.04205727577209473,
-0.019180942326784134,
0.024529121816158295,
-0.01143766287714243,
0.022280799224972725,
0.03839061036705971,
0.0025157141499221325,
-0.008024904876947403,
-0.044364653527736664,
-0.011675036512315273,
-0.061231035739183426,
0.053992416709661484,
... |
PMID:18448 | Affinity labeling of adenine nucleotide-related enzymes with reactive adenine nucleotide analogs. I. Affinity labeling of glyceraldehyde 3-phosphate dehydrogenase and myokinase with a reactive AMP analog. | Rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPD) and myokinase (MK) were rapidly inactivated by a reactive AMP analog, N6-(p-bromoacetaminobenzyl)-AMP, under mild conditions. Complete inactivation was observed when 4 and 0.3 mol of the reagent with respect to enzyme were reacted with GPD and MK, respective... | Affinity labeling of adenine nucleotide-related enzymes with reactive adenine nucleotide analogs. I. Affinity labeling of glyceraldehyde 3-phosphate dehydrogenase and myokinase with a reactive AMP analog. Rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPD) and myokinase (MK) were rapidly inactivated by a reac... | [
-0.06596919894218445,
0.001450121751986444,
-0.016258783638477325,
-0.00412070332095027,
0.034129418432712555,
-0.04287560284137726,
0.0434337817132473,
0.0216999351978302,
-0.08294198662042618,
-0.006468416191637516,
0.06740111857652664,
-0.05380707234144211,
0.0017298441380262375,
-0.005... |
PMID:18442 | Survey for alpha-(1 leads to 3)-glucanase activity among yeasts. | Activity of alpha-(1 leads to 3)-glucanase was found in species of Cryptococcus, Rhodotorula, and Endomyces. Observations on the expression and stability of this enzyme in Rhodotorula minuta var. texensis was presented. | Survey for alpha-(1 leads to 3)-glucanase activity among yeasts. Activity of alpha-(1 leads to 3)-glucanase was found in species of Cryptococcus, Rhodotorula, and Endomyces. Observations on the expression and stability of this enzyme in Rhodotorula minuta var. texensis was presented. | [
0.00283792894333601,
-0.03633556142449379,
0.015360155142843723,
0.006965549197047949,
-0.00432422012090683,
-0.04896673560142517,
-0.04072492942214012,
0.05281299352645874,
-0.010572765953838825,
0.023401247337460518,
0.03403124958276749,
-0.08957920968532562,
-0.04734860733151436,
-0.028... |
PMID:18449 | Stereochemical studies of hydrogen incorporation from nucleotides with fatty acid synthetase from Brevibacterium ammoniagenes. | The biosynthesis of fatty acids from malonyl-CoA and acetyl-CoA was investigated with an enzyme preparation which was purified 100-fold from Brevibacterium ammoniagenes. Fatty acids synthesized in the presence of D2O and stereospecifically deuterated NADPH and NADH were isolated and analyzed by mass chromatography to e... | Stereochemical studies of hydrogen incorporation from nucleotides with fatty acid synthetase from Brevibacterium ammoniagenes. The biosynthesis of fatty acids from malonyl-CoA and acetyl-CoA was investigated with an enzyme preparation which was purified 100-fold from Brevibacterium ammoniagenes. Fatty acids synthesized... | [
-0.06510622799396515,
0.0032909212168306112,
-0.06300999969244003,
0.01746302843093872,
0.05173588916659355,
-0.010121318511664867,
-0.012042288668453693,
0.028078151866793633,
-0.07027935236692429,
0.009014657698571682,
0.04064321145415306,
-0.10770605504512787,
0.018689844757318497,
-0.1... |
PMID:18450 | Chemical modifications of ribonuclease U1. | In order to obtain information on the nature of the amino acid residues involved in the activity of ribonuclease U1 [EC 3.1.4.8], various chemical modifications of the enzyme were carried out. RNase U1 was inactivated by reaction with iodoacetate at pH 5.5 with concomitant incorporation of 1 carboxymethyl group per mol... | Chemical modifications of ribonuclease U1. In order to obtain information on the nature of the amino acid residues involved in the activity of ribonuclease U1 [EC 3.1.4.8], various chemical modifications of the enzyme were carried out. RNase U1 was inactivated by reaction with iodoacetate at pH 5.5 with concomitant inc... | [
-0.06654851883649826,
-0.028638474643230438,
0.01184146199375391,
-0.019865291193127632,
-0.020506644621491432,
0.002298334613442421,
0.022271249443292618,
0.01483389176428318,
-0.029482631012797356,
0.03317949175834656,
0.05604876950383186,
-0.06383208185434341,
0.030363837257027626,
-0.0... |
PMID:18451 | Purification and some properties of cyclohexylamine oxidase from a Pseudomonas sp. | Cyclohexylamine oxidase was purified 90-fold from cell-free extracts of Pseudomonas sp. capable of assimilating sodium cyclamate. The purified enzyme was homogeneous in disc electrophoresis, and the molecular weight was found to be approximately 80,000 by gel filtration. The enzyme catalyzed the following reaction: cyc... | Purification and some properties of cyclohexylamine oxidase from a Pseudomonas sp. Cyclohexylamine oxidase was purified 90-fold from cell-free extracts of Pseudomonas sp. capable of assimilating sodium cyclamate. The purified enzyme was homogeneous in disc electrophoresis, and the molecular weight was found to be appro... | [
-0.07905708253383636,
-0.03540847823023796,
-0.09787390381097794,
0.04434872791171074,
0.06778986752033234,
-0.08081984519958496,
0.01747390255331993,
0.019463397562503815,
-0.048329588025808334,
-0.01287784706801176,
0.020166892558336258,
-0.030965231359004974,
0.01555258221924305,
0.0499... |
PMID:18455 | Purification and properties of phenylalanine ammonia-lyase in cut-injured sweet potato. | L-Phenylalanine ammonia-lyase (PAL) activity was developed in response to cut injury in sweet potato root tissue. The enzyme was purified from tissue incubated for 1 day after slicing by ammonium sulfate fractionation, column chromatographies on L-phenylalanyl Sepharose 4B, phosphocellulose. Sephadex G-200 and Sepharos... | Purification and properties of phenylalanine ammonia-lyase in cut-injured sweet potato. L-Phenylalanine ammonia-lyase (PAL) activity was developed in response to cut injury in sweet potato root tissue. The enzyme was purified from tissue incubated for 1 day after slicing by ammonium sulfate fractionation, column chroma... | [
-0.05299505963921547,
-0.023535773158073425,
-0.034722328186035156,
0.010076644830405712,
0.04735535383224487,
-0.06294630467891693,
0.0500892773270607,
0.06300549954175949,
-0.05365186929702759,
0.026259858161211014,
0.014000365510582924,
-0.08899036049842834,
0.06323423236608505,
0.06067... |
PMID:18457 | The behavior of 9-aminoacridine as an indicator of transmembrane pH difference in liposomes of natural bacterial phospholipids. | The behavior of 9-aminoacridine as an indicator of pH differences artificially set across a membrane has been reexamined in liposomes prepared from bacterial phospholipids extracted from chromatophores of Rhodopseudomonas capsulata grown photoheterotrophically. The dye behaves as an ideal indicator for pH differences l... | The behavior of 9-aminoacridine as an indicator of transmembrane pH difference in liposomes of natural bacterial phospholipids. The behavior of 9-aminoacridine as an indicator of pH differences artificially set across a membrane has been reexamined in liposomes prepared from bacterial phospholipids extracted from chrom... | [
-0.06173693761229515,
-0.007321883924305439,
-0.03181130066514015,
0.03955555707216263,
0.006189548410475254,
-0.013230489566922188,
0.06104491651058197,
0.027644112706184387,
-0.04013698175549507,
-0.029422203078866005,
0.036047711968421936,
-0.07494979351758957,
-0.010275469161570072,
0.... |
PMID:18462 | CDP-diglyceride:inositol transferase from rat liver. Purification and properties. | CDP-diglyceride:inositol transferase, which catalyzes the final step of the de novo synthesis of phosphatidylinositol, was solubilized by sodium cholate from microsomes prepared from rat liver and purified by ammonium sulfate fractionation, sucrose density gradient centrifugation, and DEAE-cellulose column chromatograp... | CDP-diglyceride:inositol transferase from rat liver. Purification and properties. CDP-diglyceride:inositol transferase, which catalyzes the final step of the de novo synthesis of phosphatidylinositol, was solubilized by sodium cholate from microsomes prepared from rat liver and purified by ammonium sulfate fractionatio... | [
-0.05207964777946472,
-0.07078390568494797,
-0.00248118513263762,
0.009173013269901276,
-0.05193161964416504,
-0.05432797223329544,
0.056042350828647614,
0.06862837821245193,
-0.04391999915242195,
-0.03057786636054516,
0.03894072771072388,
-0.08021849393844604,
-0.005581866018474102,
-0.02... |
PMID:18463 | Characterization of the glutamine site of Escherichia coli guanosine 5'-monophosphate synthetase. | Alkylation of guanosine 5'-monophosphate (GMP) synthetase with the glutamine analogs L-2-amino-4-oxo-5-chloropentanoic acid (chloroketon) and 6-diazo-5-oxonorleucine (DON) inactivated glutamine- and NH3-dependent GMP synthetase. Inactivation exhibited second order kinetics. Complete inactivation was accompanied by cova... | Characterization of the glutamine site of Escherichia coli guanosine 5'-monophosphate synthetase. Alkylation of guanosine 5'-monophosphate (GMP) synthetase with the glutamine analogs L-2-amino-4-oxo-5-chloropentanoic acid (chloroketon) and 6-diazo-5-oxonorleucine (DON) inactivated glutamine- and NH3-dependent GMP synth... | [
-0.06244871765375137,
-0.055752575397491455,
-0.020969923585653305,
-0.05047071352601051,
0.008304908871650696,
0.010008844546973705,
0.05426734685897827,
0.0044707623310387135,
-0.04757540300488472,
0.001902438816614449,
0.025986114516854286,
-0.062310658395290375,
0.00020474828488659114,
... |
PMID:18464 | Nature of the lectin-induced activation of plasma membrane Mg2+ATPase. | The Mg2+ATPase activity of liver plasma membranes decreases markedly with increasing temperature above 30 degrees. This negative temperature dependency is counteracted by the binding of wheat germ agglutinin, concanavalin A, or Ricinus communis agglutinin (at concentrations greater than or equal 0.5 mg/ml) to membranes... | Nature of the lectin-induced activation of plasma membrane Mg2+ATPase. The Mg2+ATPase activity of liver plasma membranes decreases markedly with increasing temperature above 30 degrees. This negative temperature dependency is counteracted by the binding of wheat germ agglutinin, concanavalin A, or Ricinus communis aggl... | [
-0.07041503489017487,
-0.04035399109125137,
-0.005479234736412764,
0.017695238813757896,
0.020450731739401817,
-0.0507313534617424,
0.0908738374710083,
0.07085253298282623,
-0.03989597037434578,
-0.05539184436202049,
0.025458822026848793,
-0.0692942887544632,
-0.01137731783092022,
0.022651... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.