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PMID:18792 | Microcalorimetric studies of human platelet metabolism at rest. Influence of pH, temperature, cell concentration, preparation methods and storage. | Heat production in human platelets has been measured under different conditions of pH, temp., cell concentration, preparation and storage time. The heat effect was found to increase linearly in the pH range 7.00-7.95, by 20% per pH unit. The temp. coefficient for the heat effect was determined to be Q10 = 2.0 for the t... | Microcalorimetric studies of human platelet metabolism at rest. Influence of pH, temperature, cell concentration, preparation methods and storage. Heat production in human platelets has been measured under different conditions of pH, temp., cell concentration, preparation and storage time. The heat effect was found to ... | [
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PMID:18793 | A deficient pyruvate kinase with an electrophoretically slow-moving component. | A deficient erythrocyte pyruvate kinase observed in a patient with congenital non-spherocytic anaemia was characterized by the following properties: very low activity in haemolysates, decreased thermal stability, slightly increased urea denaturation, high affinity for PEP, poor FDP activation, normal ATP inhibition, de... | A deficient pyruvate kinase with an electrophoretically slow-moving component. A deficient erythrocyte pyruvate kinase observed in a patient with congenital non-spherocytic anaemia was characterized by the following properties: very low activity in haemolysates, decreased thermal stability, slightly increased urea dena... | [
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PMID:18795 | Asthma and urticaria during disodium cromoglycate treatment. A case report. | A 10-year-old asthmatic boy began to suffer from urticarial rash and moderately severe bronchospasm after 8 weeks' treatment with disodium cromoglycate. Initially, DSCG had helped to control his asthmatic attacks, and steroid therapy could be discontinued. Inhalation provocation test with DSCG aerosol, 4 months after s... | Asthma and urticaria during disodium cromoglycate treatment. A case report. A 10-year-old asthmatic boy began to suffer from urticarial rash and moderately severe bronchospasm after 8 weeks' treatment with disodium cromoglycate. Initially, DSCG had helped to control his asthmatic attacks, and steroid therapy could be d... | [
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PMID:18796 | [Effect of alclofenac on the prothrombin level in patients under treatment with anticoagulants]. | Simultaneous administration of the anticoagulants acenocoumarol, phenprocoumon or chlorindion and the antirheumatic substance alclofenac in long term trials has no observable influence on the prothrombin time of stabilized patients. When the anticoagulant (acenocoumarol or phenprocoumon) and the alclofenac therapy are ... | [Effect of alclofenac on the prothrombin level in patients under treatment with anticoagulants]. Simultaneous administration of the anticoagulants acenocoumarol, phenprocoumon or chlorindion and the antirheumatic substance alclofenac in long term trials has no observable influence on the prothrombin time of stabilized ... | [
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PMID:18800 | An entomological survey on the mosquitoes of Wuvulu Island, Papua-New Guinea. | An entomological survey in Wuvulu Island, Papua New Guinea, in August 1975 and 1976 shows the presence of six mosquito species: Aedes (S.) hebrideus, AE. (F.) notoscriptus, AE. (V.) lineatus, ? Ae. (L.) dasyorrhus, Culex pipiens fatigans and Armigeres breinli. The medical significance of these mosquitoes is discussed, ... | An entomological survey on the mosquitoes of Wuvulu Island, Papua-New Guinea. An entomological survey in Wuvulu Island, Papua New Guinea, in August 1975 and 1976 shows the presence of six mosquito species: Aedes (S.) hebrideus, AE. (F.) notoscriptus, AE. (V.) lineatus, ? Ae. (L.) dasyorrhus, Culex pipiens fatigans and ... | [
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PMID:18801 | The effect of acid-stimulating and inhibiting drugs on the ultrastructure of gastric parietal cells in man. | The ultrastructure of the human parietal cell at rest, after stimulation of gastric acid secretion by pentagastrin and after inhibition with propantheline or cimetidine, an H2-receptor antagonist, was studied. On stimulation there was an increase in the total secretory surface area of the gastric gland and canaliculus,... | The effect of acid-stimulating and inhibiting drugs on the ultrastructure of gastric parietal cells in man. The ultrastructure of the human parietal cell at rest, after stimulation of gastric acid secretion by pentagastrin and after inhibition with propantheline or cimetidine, an H2-receptor antagonist, was studied. On... | [
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PMID:18802 | The effect of cyclizine hydrochloride on lower oesophageal sphincter pressure in man. | Gastro-oesophageal reflux and pulmonary aspiration of acid gastric content remain significant causes of morbidity and mortality. A drug which increases lower oesophageal sphincter (LOS) tone would reduce this hazard. The effect of LOS function of intravenous cyclizine (25 mg), in half the recommended adult dose, was in... | The effect of cyclizine hydrochloride on lower oesophageal sphincter pressure in man. Gastro-oesophageal reflux and pulmonary aspiration of acid gastric content remain significant causes of morbidity and mortality. A drug which increases lower oesophageal sphincter (LOS) tone would reduce this hazard. The effect of LOS... | [
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PMID:18806 | The role of adrenergic stimulation in the pathogenesis of pulmonary insufficiency. | Recent studies have shown that epinephrine (E), norepinephrine (NE), and isoproterenol (I) caus'e substantial pulmonary shunting. This study was undertaken to determine the role of alpha (pulmonary vasconconstriction) and beta (pulmonary vasodilatation) adrenergic stimulation in the pathogenesis of pulmonary insufficie... | The role of adrenergic stimulation in the pathogenesis of pulmonary insufficiency. Recent studies have shown that epinephrine (E), norepinephrine (NE), and isoproterenol (I) caus'e substantial pulmonary shunting. This study was undertaken to determine the role of alpha (pulmonary vasconconstriction) and beta (pulmonary... | [
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PMID:18807 | Dilemmas in the early diagnosis and treatment of multiple endocrine adenomatosis, type II. | Fifteen patients with the diagnosis of multiple endocrine adenomatosis, type II, syndrome (MEA II) were reported from a single center to discuss the dilemmas of early detection and treatment of the adrenal medullary, thyroid, and parathyroid gland diseases. Ten patients came from three families. Three of the patients d... | Dilemmas in the early diagnosis and treatment of multiple endocrine adenomatosis, type II. Fifteen patients with the diagnosis of multiple endocrine adenomatosis, type II, syndrome (MEA II) were reported from a single center to discuss the dilemmas of early detection and treatment of the adrenal medullary, thyroid, and... | [
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PMID:18809 | Potentiation by the injection vehicle of the teratological action of acetazolamide in rats. | The high alkalinity of the injection vehicle of certain parenteral solutions of acetazolamide produces necrosis of the skin upon sc injection. The possible modification of this effect on the teratogenicity of acetazolamide was examined. Acetazolamide in a vehicle of pH 10.5 produced 36.6% fetal malformations, in a vehi... | Potentiation by the injection vehicle of the teratological action of acetazolamide in rats. The high alkalinity of the injection vehicle of certain parenteral solutions of acetazolamide produces necrosis of the skin upon sc injection. The possible modification of this effect on the teratogenicity of acetazolamide was e... | [
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PMID:18811 | Purification and properties of a neutral protease from soil bacterium WM 122. | An extracellular protease SN 687, secreted by the soil bacterium isolate WM 122, has been purified by means of gel filtration, ammonium sulfate precipitation, DEAE-Sephadex and hydroxylapatite chromatography. Apparent homogeneity was ascertained by polyacrylamide gel electrophoresis. The protease was inactivated by eth... | Purification and properties of a neutral protease from soil bacterium WM 122. An extracellular protease SN 687, secreted by the soil bacterium isolate WM 122, has been purified by means of gel filtration, ammonium sulfate precipitation, DEAE-Sephadex and hydroxylapatite chromatography. Apparent homogeneity was ascertai... | [
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PMID:18819 | Fetal suppressor cells. Their influence on the cell-mediated immune responses. | The cell-mediated immune responses are significantly reduced in fetal and newborn mice, furthermore, spleen cells of these animals are able to suppress the immune responses of adult lymphocytes in a variety of situations. Newborn mice sensitized to picryl chloride within 24 hr after birth fail to develop contact sensit... | Fetal suppressor cells. Their influence on the cell-mediated immune responses. The cell-mediated immune responses are significantly reduced in fetal and newborn mice, furthermore, spleen cells of these animals are able to suppress the immune responses of adult lymphocytes in a variety of situations. Newborn mice sensit... | [
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PMID:18821 | Graft-versus-host reaction. Influence of genetic background in donor-recipient pairs incompatible for major histocompatibility complex (MHC). | In two H-2b anti-H-2d but not in H-2b anti-H2k donor-recipient combinations, graft-versus-host reaction (GVHR) mortality was found to vary as a function of the host's genetic background; the same non-major histocompatibility complex genes and/or antigens which influence GVHR mortality do not influence the intensity of ... | Graft-versus-host reaction. Influence of genetic background in donor-recipient pairs incompatible for major histocompatibility complex (MHC). In two H-2b anti-H-2d but not in H-2b anti-H2k donor-recipient combinations, graft-versus-host reaction (GVHR) mortality was found to vary as a function of the host's genetic bac... | [
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PMID:18824 | [Immunosuppressive properties of vinblastine and colchicine]. | The action of vinblastine and colchicine on the populations of antibody-forming cells, their precursors and stem cells using a model of primary immune response and in the transplantation system was studied using techniques by Jerne and Nordin (1963), Kennedy et al. (1965), and Till and McCulloch (1961). It was discover... | [Immunosuppressive properties of vinblastine and colchicine]. The action of vinblastine and colchicine on the populations of antibody-forming cells, their precursors and stem cells using a model of primary immune response and in the transplantation system was studied using techniques by Jerne and Nordin (1963), Kennedy... | [
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PMID:18826 | [Temporary characteristics of the process of stem cell inactivation by allogenic lymphocytes]. | The time during which transplated lymphocytes block proliferation and differentiation of non-syngeic stem cells has been determined by retrasplantation of immuno-competent cells from one lethally irradiated recipient to another one. It was established that process of inactivation of CFU by allogeneic lymphocytes procee... | [Temporary characteristics of the process of stem cell inactivation by allogenic lymphocytes]. The time during which transplated lymphocytes block proliferation and differentiation of non-syngeic stem cells has been determined by retrasplantation of immuno-competent cells from one lethally irradiated recipient to anoth... | [
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PMID:18828 | [Physicochemical characteristics of calcium binding with plasma membranes of rabbit skeletal muscles]. | It is established that Ca2+ binding with rabbit skeletal muscles plasmatic membrane depends on this cation concentration in the incubating medium. pH, temperature, incubation period and presence of Mg ions in the medium affect the Ca2+-binding ability of sarcolemma. The entropic changes observed in sarcolemma Ca2+ bind... | [Physicochemical characteristics of calcium binding with plasma membranes of rabbit skeletal muscles]. It is established that Ca2+ binding with rabbit skeletal muscles plasmatic membrane depends on this cation concentration in the incubating medium. pH, temperature, incubation period and presence of Mg ions in the medi... | [
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PMID:18830 | [Properties of chymotrypsin proteinase from Aspergillus oryzae]. | Chymotrypsin-type proteinase is detected in the proteolytic system of Asp. oryzae. The action of it and chymotrypsin is shown to depend on formaldehyde. Hydrolysis of substrates, p-nitrophenyl acetate (p-NPA) and N-benzoyl-tyrosine methyl ether (BTME), by both preparations is almost the same. The obtained activity pH-o... | [Properties of chymotrypsin proteinase from Aspergillus oryzae]. Chymotrypsin-type proteinase is detected in the proteolytic system of Asp. oryzae. The action of it and chymotrypsin is shown to depend on formaldehyde. Hydrolysis of substrates, p-nitrophenyl acetate (p-NPA) and N-benzoyl-tyrosine methyl ether (BTME), by... | [
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PMID:18835 | Feasibility of localizing ectopic testes by 131I-labeled luteinizing hormone scintigraphy. | A new method for localizing ectopic testes preoperatively was investigated in rats. Twenty hours after administration of iodine-131 luteinizing hormone the position of normal descended testes was easily identified by scintigraphy. Clinically, this technique may offer a noninvasive and practical means of locating testes... | Feasibility of localizing ectopic testes by 131I-labeled luteinizing hormone scintigraphy. A new method for localizing ectopic testes preoperatively was investigated in rats. Twenty hours after administration of iodine-131 luteinizing hormone the position of normal descended testes was easily identified by scintigraphy... | [
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PMID:18831 | [Effect of acid anions and medium acidity on pH during a change of immunoglobulin G, peculiar to malignant growth, to water-insoluble state]. | Affinity of an acid anion for proteins has a decisive effect on conditions for detecting using an acid medium immunoglobulin G peculiar to the malignant growth in blood serum of patients with cancer. Depending on the protein affinity of the anion of the acid used for the reaction immunoglobulin G appearing in blood of ... | [Effect of acid anions and medium acidity on pH during a change of immunoglobulin G, peculiar to malignant growth, to water-insoluble state]. Affinity of an acid anion for proteins has a decisive effect on conditions for detecting using an acid medium immunoglobulin G peculiar to the malignant growth in blood serum of ... | [
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PMID:18832 | [Incorporation in vivo of 14C-precursors into pyrimidine nucleotides of chicken liver and spleen tissues]. | Maximum incorporation of the label after administration of 14C-bicarbonate to free pyrimidine nucleotides begins by the 60th minute. Radioactivity of cytidine nucleotides at all time points is four-eight times as low as that of uridine nucleotides. 2-14C-orotic acid is incorporated into acid-soluble nucleotides and RNA... | [Incorporation in vivo of 14C-precursors into pyrimidine nucleotides of chicken liver and spleen tissues]. Maximum incorporation of the label after administration of 14C-bicarbonate to free pyrimidine nucleotides begins by the 60th minute. Radioactivity of cytidine nucleotides at all time points is four-eight times as ... | [
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PMID:18829 | [Some mechanisms of carbohydrate metabolism regulation with NADP participation]. | It is shown that in the presence of NADP in the myocardium extracts glucose-6-phosphate is transformed into fructose-6-phosphate, fructose-1,6-diphosphate and lactate. The intensity of this transformation is close to that when NAD is introduced. The addition of crystalline glucose-6-phosphate dehydrogenase to the extr... | [Some mechanisms of carbohydrate metabolism regulation with NADP participation]. It is shown that in the presence of NADP in the myocardium extracts glucose-6-phosphate is transformed into fructose-6-phosphate, fructose-1,6-diphosphate and lactate. The intensity of this transformation is close to that when NAD is intro... | [
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PMID:18833 | [Dissociation of Penicillium vitale catalase under the effect of urea and acid pH]. | Conditions are studied for Penicillium vitale catalase dissociation into subunits under the effect of urea (0.7-8.5 M) and acid pH (5.0-2.0). In 8.0 M urea (pH 5.0) a molecule of the P. vitale catalase dissociates with formation of the components, the sedimentation coefficient of which is 2.4+/-0.2S, the molecular weig... | [Dissociation of Penicillium vitale catalase under the effect of urea and acid pH]. Conditions are studied for Penicillium vitale catalase dissociation into subunits under the effect of urea (0.7-8.5 M) and acid pH (5.0-2.0). In 8.0 M urea (pH 5.0) a molecule of the P. vitale catalase dissociates with formation of the ... | [
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PMID:18836 | [Changes in enzyme activity induced by experimental aflatoxicosis in dairy cows]. | The activities of GOT, GPT, LDH, gamma-glutamyltranspeptidase (gamma-GTP), alkaline phosphatase (AP), glutamate dehydrogenase (GLDH) and the concentrations of bilirubin in blood plasma after a single intraruminal application of aflatoxins were studied in four dairy cows. The maximum changes in the activities of the enz... | [Changes in enzyme activity induced by experimental aflatoxicosis in dairy cows]. The activities of GOT, GPT, LDH, gamma-glutamyltranspeptidase (gamma-GTP), alkaline phosphatase (AP), glutamate dehydrogenase (GLDH) and the concentrations of bilirubin in blood plasma after a single intraruminal application of aflatoxins... | [
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PMID:18837 | [Chronic metabolic acidosis in dairy cows]. | Complex clinical and clinico-biochemical examination of the blood, urine and rumen liquor in a herd of dairy cows revealed chronical metabolic acidosis accompanied by rumen dysfunction and by a reduced butterfat content of milk. During the first examination of the acid-base state of the blood was almost at a standard l... | [Chronic metabolic acidosis in dairy cows]. Complex clinical and clinico-biochemical examination of the blood, urine and rumen liquor in a herd of dairy cows revealed chronical metabolic acidosis accompanied by rumen dysfunction and by a reduced butterfat content of milk. During the first examination of the acid-base s... | [
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PMID:18838 | [Significance of ruminal juice examination in the diagnosis of subclinical rumen dysfunction]. | The suitability of the metabolic test of rumen liquor for the diagnosis of subclinical rumen dysfunction was tested. The test for the assessment of the metabolic profile of the rumen included: the determination of pH, total titration acidity in clinical units, lactic acid in mg%, fatty acids in mmol 1-1, ammonia N in m... | [Significance of ruminal juice examination in the diagnosis of subclinical rumen dysfunction]. The suitability of the metabolic test of rumen liquor for the diagnosis of subclinical rumen dysfunction was tested. The test for the assessment of the metabolic profile of the rumen included: the determination of pH, total t... | [
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PMID:18843 | HLA-antibody-induced 14C-serotonin release from platelets. A methodological analysis. | The prerequisites and kinetics of HLA-antibody-induced 14C-serotonin release from platelets were investigated with five HLA-specific antisera. By studying the influence of incubation time, temperature, pH, platelet count, stirring and extent of platelet labeling, optimal results were obtained after 30 (to 60) min of in... | HLA-antibody-induced 14C-serotonin release from platelets. A methodological analysis. The prerequisites and kinetics of HLA-antibody-induced 14C-serotonin release from platelets were investigated with five HLA-specific antisera. By studying the influence of incubation time, temperature, pH, platelet count, stirring and... | [
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PMID:18839 | [Electrophoretic and kinetic properties of the erythrocyte glucose-6-phosphate dehydrogenase of patients with hemolytic anemia related to a deficit in the activity of that enzyme]. | Partially purified glucose-6-phosphate dehydrogenase (G6PD) was studied in erythrocytes of patients with hereditary hemolytic anemia. Kinetic and electrophoretic properties of G6PD distinctly varied both in patients--homozygotes and in maternal heterozygotes. All the enzymes studied together with the decreased activity... | [Electrophoretic and kinetic properties of the erythrocyte glucose-6-phosphate dehydrogenase of patients with hemolytic anemia related to a deficit in the activity of that enzyme]. Partially purified glucose-6-phosphate dehydrogenase (G6PD) was studied in erythrocytes of patients with hereditary hemolytic anemia. Kinet... | [
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PMID:18841 | [Purification and several properties of thiamine pyrophosphokinase from rat liver]. | Thiamin pyrophosphokinase (TPK) (EC 2.7.6.2) was isolated and purified from rat liver tissue ion in exchange chromatography, rechromatography and gel filtration. The enzyme was purified 3000-fold with yield of 12%, it was homogenous in polyacrylamide gel disc electrophoresis. TPK had two pH optima; Km value for thiamin... | [Purification and several properties of thiamine pyrophosphokinase from rat liver]. Thiamin pyrophosphokinase (TPK) (EC 2.7.6.2) was isolated and purified from rat liver tissue ion in exchange chromatography, rechromatography and gel filtration. The enzyme was purified 3000-fold with yield of 12%, it was homogenous in ... | [
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PMID:18842 | [Immunochemical characteristics of hydrocortisone induced and hydrocortisone non-induced rat liver tyrosine aminotransferase isoenzymes]. | Two isoenzymes of tyrosine aminotransferase (induced and noninduced by hydrocortisone were isolated from rat liver tissue and subjected to chromatographic purification. Specific antibodies with high titer were obtained after immunization of rabbits by the inducible isoenzyme. The antigenic properties of the obtained ty... | [Immunochemical characteristics of hydrocortisone induced and hydrocortisone non-induced rat liver tyrosine aminotransferase isoenzymes]. Two isoenzymes of tyrosine aminotransferase (induced and noninduced by hydrocortisone were isolated from rat liver tissue and subjected to chromatographic purification. Specific anti... | [
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PMID:18846 | Contamination of rat urine with gut flora using all-glass metabolism cages for collection of urine and faeces. | In rat urine collected in all-glass metabolism cages, at least four strains of intestinal microflora were found: two types of E. coli, Enterobacter cloaceae and Proteus vulgaris. The number of bacteria of each strain increased with time. 2. The pH of the urine increased from 6-9 after 24 h to 8-95 after 120 h. The pH o... | Contamination of rat urine with gut flora using all-glass metabolism cages for collection of urine and faeces. In rat urine collected in all-glass metabolism cages, at least four strains of intestinal microflora were found: two types of E. coli, Enterobacter cloaceae and Proteus vulgaris. The number of bacteria of each... | [
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PMID:18847 | [Influence of the age of old primiparae on the perinatal infant morbidity and mortility (author's transl)]. | 157 old primiparae (greater than 30 a) have been compared to a randomised control group of primiparae between the 16th and 30th year of age. In addition to the perinatal infant mortality rate, the number of children with malnutrition, the frequency of premature babies, the presence of a low Apgar score (less than or eq... | [Influence of the age of old primiparae on the perinatal infant morbidity and mortility (author's transl)]. 157 old primiparae (greater than 30 a) have been compared to a randomised control group of primiparae between the 16th and 30th year of age. In addition to the perinatal infant mortality rate, the number of child... | [
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PMID:18848 | [Pharmacokinetic of piracetam during labour influence to acid-base-status in maternal and fetal blood (author's transl)]. | PIRACETAM concentrations in fetal and maternal blood were measured during the first and second stage of labor and the elimination in maternal and fetal blood was studied. Fetal heart-rate, pH- and base-excess of the maternal and fetal blood were investigated to evaluate the influence of PIRACETAM on the acid-base-statu... | [Pharmacokinetic of piracetam during labour influence to acid-base-status in maternal and fetal blood (author's transl)]. PIRACETAM concentrations in fetal and maternal blood were measured during the first and second stage of labor and the elimination in maternal and fetal blood was studied. Fetal heart-rate, pH- and b... | [
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PMID:18849 | Studies on in vitro survival of Isoparorchis hypselobagri. | Adult parasites, Isoparorchis hypselobagri were maintained in vitro in four basic salt solutions, viz. Stephenson saline, AB saline, Tyrode's solution and Locke's solution. Survival was prolonged by adding sugars to Tyrode's solution. Of all the sugars, glucose was found most effective and parasites survived for 39 day... | Studies on in vitro survival of Isoparorchis hypselobagri. Adult parasites, Isoparorchis hypselobagri were maintained in vitro in four basic salt solutions, viz. Stephenson saline, AB saline, Tyrode's solution and Locke's solution. Survival was prolonged by adding sugars to Tyrode's solution. Of all the sugars, glucose... | [
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PMID:18858 | [On the enzymatic breakdown of tripolyphosphate and diphosphate in comminuted meat. XI. Influence of heating and freezing (author's transl)]. | The tripolyphosphatase and diphosphatase activities of comminuted bovine muscle increase with rising temperature until at about 40 degrees C a denaturation of the enzyme proteins occurs. Prae or post rigor frozen bovine muscle, which was stored at -18 degrees C, shows after thawing and mincing the same tripolyphosphata... | [On the enzymatic breakdown of tripolyphosphate and diphosphate in comminuted meat. XI. Influence of heating and freezing (author's transl)]. The tripolyphosphatase and diphosphatase activities of comminuted bovine muscle increase with rising temperature until at about 40 degrees C a denaturation of the enzyme proteins... | [
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PMID:18859 | [Formation of dehydroalanine, lanthionine and lysinoalanine during heat treatment of beta-lactoglobuline A (author's transl)]. | Solutions of beta-lactoglobulin A were heated at 97.5 degrees C at pH 6.9 and 9.8 80 min. The formation of dehydroalanine, lanthionine and lysinoalanine as well as changes in the levels of cysteine, cystine and the basic amino acids were recorded. Lanthionine (equal amounts of the 1- and the mesoform) was formed only i... | [Formation of dehydroalanine, lanthionine and lysinoalanine during heat treatment of beta-lactoglobuline A (author's transl)]. Solutions of beta-lactoglobulin A were heated at 97.5 degrees C at pH 6.9 and 9.8 80 min. The formation of dehydroalanine, lanthionine and lysinoalanine as well as changes in the levels of cyst... | [
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PMID:18861 | [Detection and quantitative estimation of 2,2-diethyl-4-pentenamide in a fatal case of poisoning (author's transl)]. | Toxicological investivation in a fatal case of poisoning by Novo-DolestanR and DoromaR is presented with methods for identification and quantitative estimation of 2,2-diethyl-4-pentenamide especially. The findings confirm 2,2-diethyl-4-pentenamide as the main toxic agent in this case. | [Detection and quantitative estimation of 2,2-diethyl-4-pentenamide in a fatal case of poisoning (author's transl)]. Toxicological investivation in a fatal case of poisoning by Novo-DolestanR and DoromaR is presented with methods for identification and quantitative estimation of 2,2-diethyl-4-pentenamide especially. Th... | [
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PMID:18863 | [Evaluation of congenital-cryptorchid testicles after surgical treatment (author's transl)]. | The volume of 271 congenital-cryptorchid testicles which were subject to surgical treatment was compared with that of 128 descended testicles of patients of the same age. Undescended testicles, also after successful surgical treatment, remain smaller on volume than descended ones. By means of the hitting method of the ... | [Evaluation of congenital-cryptorchid testicles after surgical treatment (author's transl)]. The volume of 271 congenital-cryptorchid testicles which were subject to surgical treatment was compared with that of 128 descended testicles of patients of the same age. Undescended testicles, also after successful surgical tr... | [
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PMID:18864 | Accentuation of Staphylococcal hemolysis (CAMP-like test) by pneumococci. | A CAMP-like phenomenon can be observed in Streptococcus pneumoniae. It is supposed to be caused likewise as in group B streptococci by a haemolysis accentuating factor. However, the form of the accentuated haemolysis is different from that in group B streptococci and similar to that in listeria. | Accentuation of Staphylococcal hemolysis (CAMP-like test) by pneumococci. A CAMP-like phenomenon can be observed in Streptococcus pneumoniae. It is supposed to be caused likewise as in group B streptococci by a haemolysis accentuating factor. However, the form of the accentuated haemolysis is different from that in gro... | [
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PMID:18867 | A catalogue of isohormones of human growth hormone based on quantitative polyacrylamide gel electrophoresis. | With the growing recognition that all polypeptide hormones exist in heterogeneous forms, i.e., isohormones, this study represents the initial development of a comprehensive catalogue of the various isohormone species of human growth hormone (hGH) in relation to molecular structure. The catalogue is based primarily on r... | A catalogue of isohormones of human growth hormone based on quantitative polyacrylamide gel electrophoresis. With the growing recognition that all polypeptide hormones exist in heterogeneous forms, i.e., isohormones, this study represents the initial development of a comprehensive catalogue of the various isohormone sp... | [
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PMID:18866 | [Alteration of several indices of carbohydrate metabolism in the blood and cerebrospinal fluid following surgery on patients with intracranial aneurysms]. | The content of the lactic acid (LA) and pyruvic acid (PA) was determined pre- and postoperatively in the arterial blood and CSF of 31 patients with intracranial aneurysms. A considerable elevation of the concentration of LA and PA was noted along with an increasing LA/PA in the CSF of patients with symptoms of ischaemi... | [Alteration of several indices of carbohydrate metabolism in the blood and cerebrospinal fluid following surgery on patients with intracranial aneurysms]. The content of the lactic acid (LA) and pyruvic acid (PA) was determined pre- and postoperatively in the arterial blood and CSF of 31 patients with intracranial aneu... | [
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PMID:18876 | [Behavior therapy and neurotic behavior]. | The first part of the lecture presents three classical aspects of behavior therapy: therapeutic efficiency, utilisation of well defined methods, rapidity of treatment. Emphasis is brought to the importance of behavior analysis and to the dangers arisen from insufficient knowledge or ignorance of learning theories and f... | [Behavior therapy and neurotic behavior]. The first part of the lecture presents three classical aspects of behavior therapy: therapeutic efficiency, utilisation of well defined methods, rapidity of treatment. Emphasis is brought to the importance of behavior analysis and to the dangers arisen from insufficient knowled... | [
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PMID:18875 | [Behavior therapy of fear of flying in professional pilots]. | The theorical frame proposed by behaviour principles seems to have an explanatory value in the genesis of some troubles of traumatic origin. This is the case for fear of flying which can appear suddenly in airline personnel following accidents, troubles or problems while flying and which could bring a definitive incapa... | [Behavior therapy of fear of flying in professional pilots]. The theorical frame proposed by behaviour principles seems to have an explanatory value in the genesis of some troubles of traumatic origin. This is the case for fear of flying which can appear suddenly in airline personnel following accidents, troubles or pr... | [
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PMID:18877 | [Schultz autogenic training and galvanic skin response in the systematic desensitization of a compulsive phobia]. | A patient suffering suicidal phobia and resistant to antidepressants as well as electroconvulsive therapy was submitted to Wolpe's systematic desensitization associated with Schult's autogenic training. Ten sessions were sufficient to cure the patient. A follow-up period now extends to one year, without relapse. The co... | [Schultz autogenic training and galvanic skin response in the systematic desensitization of a compulsive phobia]. A patient suffering suicidal phobia and resistant to antidepressants as well as electroconvulsive therapy was submitted to Wolpe's systematic desensitization associated with Schult's autogenic training. Ten... | [
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PMID:18914 | Syntheses of virus-induced thymidine kinase and viral DNA in herpes simplex type 1 virus-infected chick embryo fibroblasts. | Herpes simplex virus type 1, strain Kupka, did not replicate in chick embryo fibroblasts (CEF), but the infection was followed by the development of cytopathic changes. This effect could be abolished by UV irradiation of the virus. Virus-induced thymidine kinase was synthesized in the infected cells reaching a maximum ... | Syntheses of virus-induced thymidine kinase and viral DNA in herpes simplex type 1 virus-infected chick embryo fibroblasts. Herpes simplex virus type 1, strain Kupka, did not replicate in chick embryo fibroblasts (CEF), but the infection was followed by the development of cytopathic changes. This effect could be abolis... | [
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PMID:18915 | Differential expression of D and R components of Epstein-Barr virus early antigen after superinfection and after induction with 5-iododeoxyuridine. | Three non-productive human lymphoblastoid cell lines, NC-37, RAJI and L-1, either superinfected with Epstein-Barr (EB) virus from P3HR-1 cells or treated with 5-iododexyuridine (IUDR), were studied for the development of early antigen (EA) of EB virus. In all three superinfected cell lines, both the restricted (R) and ... | Differential expression of D and R components of Epstein-Barr virus early antigen after superinfection and after induction with 5-iododeoxyuridine. Three non-productive human lymphoblastoid cell lines, NC-37, RAJI and L-1, either superinfected with Epstein-Barr (EB) virus from P3HR-1 cells or treated with 5-iododexyuri... | [
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PMID:18916 | Production and some properties of neutralizing antigens of herpes simplex virus. | Human diploid cells (LEP) infected with herpes simplex virus (HSV) type 1 were extracted by treatment with Nonidet P-40. The content of antigens reactive with neutralizing antibody in the clarified extract was measured by the blocking test. Influence of various factors on the production of the blocking antigens (BA) wa... | Production and some properties of neutralizing antigens of herpes simplex virus. Human diploid cells (LEP) infected with herpes simplex virus (HSV) type 1 were extracted by treatment with Nonidet P-40. The content of antigens reactive with neutralizing antibody in the clarified extract was measured by the blocking test... | [
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PMID:18917 | Heterogeneity of pseudorabies virus studied by isoelectric separation. | Heterogeneity of four lines derived from a single strain of pseudorabies virus (PRV) was studied by isoelectric separation. The individual lines differed in the distribution pattern of infectious fractions separated in the pH range from 3.5 to 10.0. All virus fractions of the virulent and attenuated lines were infectio... | Heterogeneity of pseudorabies virus studied by isoelectric separation. Heterogeneity of four lines derived from a single strain of pseudorabies virus (PRV) was studied by isoelectric separation. The individual lines differed in the distribution pattern of infectious fractions separated in the pH range from 3.5 to 10.0.... | [
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PMID:18918 | Nucleic acid biosynthesis in rat embryo cells infected with X14 or H-1 parvovirus. | Nucleic acid biosynthesis was studied in rat embryo cell (REC) cultures 48 hours after infection with X14 or H-1 parvovirus. The incorporation of 14C-formate and [6-(14C]-orotic acid into purines and pyrimidines of various was lowered after infection with these parvoviruses. 14C-Formate incorporation into acid-soluble ... | Nucleic acid biosynthesis in rat embryo cells infected with X14 or H-1 parvovirus. Nucleic acid biosynthesis was studied in rat embryo cell (REC) cultures 48 hours after infection with X14 or H-1 parvovirus. The incorporation of 14C-formate and [6-(14C]-orotic acid into purines and pyrimidines of various was lowered af... | [
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PMID:18919 | Properties of virions and ribonucleoproteins of Venezuelan equine encephalomyelitis virus. | The physicochemical properties of Venezuelan equine encephalomyelitis (VEE) virus and of its ribonucleoprotein (RNP) were studied. Upon purification in a discontinuous or linear sucrose gradient, the losses of infectivity were small (25%), and 96% of cellular proteins were removed. The purified virus was homogeneous wi... | Properties of virions and ribonucleoproteins of Venezuelan equine encephalomyelitis virus. The physicochemical properties of Venezuelan equine encephalomyelitis (VEE) virus and of its ribonucleoprotein (RNP) were studied. Upon purification in a discontinuous or linear sucrose gradient, the losses of infectivity were sm... | [
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PMID:18920 | Latent infection and measles meningoencephalitis in Syrian hamsters. | A strain designated 42-Edmonston was isolated from the brain of a Syrian hamster 30 days after inoculation during the neonatal period with the reference "wild" measles virus strain Edmonston which produced a latent infection accompanied by production of measles antibody and insignificant pathomorphological changes. Int... | Latent infection and measles meningoencephalitis in Syrian hamsters. A strain designated 42-Edmonston was isolated from the brain of a Syrian hamster 30 days after inoculation during the neonatal period with the reference "wild" measles virus strain Edmonston which produced a latent infection accompanied by production ... | [
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PMID:18921 | Serodiagnosis of influenza by indirect haemagglutination test. | Results of studies on serodiagnosis of influenza A and B by the indirect haemagglutination test (IHA) with lyophilized erythrocyte diagnostic preparations, highly stable upon storage, are presented. The diagnostic value of the IHA test was in good agreement with, that of virus neutralization tests. | Serodiagnosis of influenza by indirect haemagglutination test. Results of studies on serodiagnosis of influenza A and B by the indirect haemagglutination test (IHA) with lyophilized erythrocyte diagnostic preparations, highly stable upon storage, are presented. The diagnostic value of the IHA test was in good agreement... | [
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PMID:18922 | Improved methods of influenza virus propagation. I. Enhancement of virus reproduction in cell cultures. | Comparative studies on the reproduction of a set of influenza A and B virus strains in different cell cultures were carried out. A cultivation system yielding influenza virus with high infectivity, based on the use of roller cultures of bovine embryo kidney cells, of virus strains adapted to this culture, and of a main... | Improved methods of influenza virus propagation. I. Enhancement of virus reproduction in cell cultures. Comparative studies on the reproduction of a set of influenza A and B virus strains in different cell cultures were carried out. A cultivation system yielding influenza virus with high infectivity, based on the use o... | [
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PMID:18923 | Improved methods of influenza virus propagation. II. Characteristics of cell culture and allantoic virus preparations. | Regular reproduction of influenza A virus with infectious titres of 7.4--8.5 log EID50/0.2 ml was observed in roller bovine embryo kidney cell cultures. The haemagglutinating activity of the cell culture preparations was 8-33-fold lower than that of the allantoic preparations, the infectivity being similar. Cell cultur... | Improved methods of influenza virus propagation. II. Characteristics of cell culture and allantoic virus preparations. Regular reproduction of influenza A virus with infectious titres of 7.4--8.5 log EID50/0.2 ml was observed in roller bovine embryo kidney cell cultures. The haemagglutinating activity of the cell cultu... | [
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PMID:18924 | Analysis of antibody response and immunoglobulins in sera of rabbits and guinea pigs immunized with Coxiella burnetii. | Rabbit and guinea pig sera and their immunoglobulin fractions (IgM and IgG) were examined by complement-fixation (CF), microagglutination (MA), opsonization-phagocytosis (OP) and serum protection (SP) tests at intervals after immunization with live phase I and phase II Coxiella burnetii suspensions. In general, MA anti... | Analysis of antibody response and immunoglobulins in sera of rabbits and guinea pigs immunized with Coxiella burnetii. Rabbit and guinea pig sera and their immunoglobulin fractions (IgM and IgG) were examined by complement-fixation (CF), microagglutination (MA), opsonization-phagocytosis (OP) and serum protection (SP) ... | [
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PMID:18925 | The role of the nucleus in the replication of measles virus. | The replication of measles and SSPE viruses in enucleate BSC-1 cells was measured by plaque assay, and the synthesis of virus-specific antigen was measured by indirect immunofluorescence. Titres of infectious virus produced in enucleate cells at 24 hours post inoculation (p.i.) were consistently 100-fold less, and the ... | The role of the nucleus in the replication of measles virus. The replication of measles and SSPE viruses in enucleate BSC-1 cells was measured by plaque assay, and the synthesis of virus-specific antigen was measured by indirect immunofluorescence. Titres of infectious virus produced in enucleate cells at 24 hours post... | [
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PMID:18926 | Antiviral effect of tebrofen. | Tebrofen inhibited the replication of western equine encephalomyelitis (WEE) virus in multicycle experiments in chick embryo cell cell cultures. The compound did not inhibit the replication of vaccinia and Newcastle disease viruses. | Antiviral effect of tebrofen. Tebrofen inhibited the replication of western equine encephalomyelitis (WEE) virus in multicycle experiments in chick embryo cell cell cultures. The compound did not inhibit the replication of vaccinia and Newcastle disease viruses. | [
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PMID:18927 | Effect of physical and chemical agents on the blue-green algal virus N-1. | The stability of the blue-green algal virus N-1, infecting the blue-green alga Nostoc muscorum, against temperature, EDTA and pH was studied. Ninety per cent thermal inactivation of virus occured at 55 degrees C in 20 minutes with an average inactivation rate constant of 0.07 per minute; at 60 degrees C the virus was c... | Effect of physical and chemical agents on the blue-green algal virus N-1. The stability of the blue-green algal virus N-1, infecting the blue-green alga Nostoc muscorum, against temperature, EDTA and pH was studied. Ninety per cent thermal inactivation of virus occured at 55 degrees C in 20 minutes with an average inac... | [
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PMID:18928 | Scanning and transmission electron microscopy of Rickettsia rickettsii propagated in cell culture. | Scanning electron microscopy utilizing critical-point drying and transmission electron microscopy employing air-dried agar pseudoreplicas and critical-point dried carbon replicas were used to study the surface of Rickettsia rickettsii propagated in cell culture. | Scanning and transmission electron microscopy of Rickettsia rickettsii propagated in cell culture. Scanning electron microscopy utilizing critical-point drying and transmission electron microscopy employing air-dried agar pseudoreplicas and critical-point dried carbon replicas were used to study the surface of Ricketts... | [
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PMID:18930 | Adrenergic mechanisms in infection. III. alpha-and beta-receptor blocking agents in treatment. | Raised epinephrine concentrations concentrations developed in the blood of mice near death after an intraperitoneal challenge with 10(9) Staphylococcus aureus or Escherichia coli. Both epinephrine levels were elevated in the urine near death. These challenges were infections and not intoxications, as they could be succ... | Adrenergic mechanisms in infection. III. alpha-and beta-receptor blocking agents in treatment. Raised epinephrine concentrations concentrations developed in the blood of mice near death after an intraperitoneal challenge with 10(9) Staphylococcus aureus or Escherichia coli. Both epinephrine levels were elevated in the ... | [
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PMID:18931 | Effects of pneumococcal infection on rat liver microsomal enzymes and lipogenesis by isolated hepatocytes. | Modification in the enzymatic complement and lipogenic functions of rat liver endoplasmic reticulum (ER) were shown to occur during pneumococcal sepsis. Glucose-6-phosphatase, 5'nucleotidase, esterase, and NADPH cytochrome C reductase decreased in activity by as much as 50% with respect to controls. Hydroxymethylglutar... | Effects of pneumococcal infection on rat liver microsomal enzymes and lipogenesis by isolated hepatocytes. Modification in the enzymatic complement and lipogenic functions of rat liver endoplasmic reticulum (ER) were shown to occur during pneumococcal sepsis. Glucose-6-phosphatase, 5'nucleotidase, esterase, and NADPH c... | [
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PMID:18932 | Prostaglandin E2-hemoglobin AA and SS erythrocyte interaction (prostaglandin-erythrocyte interaction). | Prostaglandin E2 (PGE2), at concentration larger than or equal to 5 x 10(4) ng/ml, induced discocyte leads to echinocyte transformation of saline-suspended hemoglobin (Hb) AA and SS erythrocytes. This erythrocyte transformation is concentration-dependent and is reversible at room temperature after 90-120 min. The Hb SS... | Prostaglandin E2-hemoglobin AA and SS erythrocyte interaction (prostaglandin-erythrocyte interaction). Prostaglandin E2 (PGE2), at concentration larger than or equal to 5 x 10(4) ng/ml, induced discocyte leads to echinocyte transformation of saline-suspended hemoglobin (Hb) AA and SS erythrocytes. This erythrocyte tran... | [
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PMID:18933 | Biological activity of dilute isoproterenol solution stored for long periods in plastic bags. | The effect of long-term storage in polyvinyl chloride bags on the biological activity and the chemical stability of isoproterenol was studied. A freshly prepared solution of isoproterenol, isoproterenol solution stored for six months and isoproterenol stored for 30 months were infused into the coronary circulation of 1... | Biological activity of dilute isoproterenol solution stored for long periods in plastic bags. The effect of long-term storage in polyvinyl chloride bags on the biological activity and the chemical stability of isoproterenol was studied. A freshly prepared solution of isoproterenol, isoproterenol solution stored for six... | [
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PMID:18936 | Continuous subcutaneous pH measurement in human fetuses: correlations with scalp and umbilical blood pH. | The subcutaneous pH values of 42 fetuses has been measured continuously during labor with the use of the electrode designed by Stamm and associates. We have obtained 60 per cent good tracings. The results have confirmed the reliability of the subcutaneous pH measurement, if the electrode is correctly inserted, when com... | Continuous subcutaneous pH measurement in human fetuses: correlations with scalp and umbilical blood pH. The subcutaneous pH values of 42 fetuses has been measured continuously during labor with the use of the electrode designed by Stamm and associates. We have obtained 60 per cent good tracings. The results have confi... | [
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PMID:18937 | Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis. | Hyperplastic liver lesions which develop following administration of hepatocarcinogens have been implicated as probable precursors for the cancers which ultimately develop. Some, and possibly all, of these putative precursor lesions are resistant to the necrogenic and growth-inhibitory action of hepatocarcinogens and o... | Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis. Hyperplastic liver lesions which develop following administration of hepatocarcinogens have been implicated as probable precursors for the cancers which ultimately develop. Some, and possibly a... | [
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PMID:18938 | Vitamin K2 colonic and ileal in vivo absorption: bile, fatty acids, and pH effects on transport. | Colonic and ileal absorption of vitamin K2 ([2-methyl-3H]menaquinone-9) was investigated in the conscious rat. When the absorption rate was plotted against the perfusate concentration, a linear relationship was found between these two parameters in the ileum and colon. The absorption rate of menaquinone by the ileum wa... | Vitamin K2 colonic and ileal in vivo absorption: bile, fatty acids, and pH effects on transport. Colonic and ileal absorption of vitamin K2 ([2-methyl-3H]menaquinone-9) was investigated in the conscious rat. When the absorption rate was plotted against the perfusate concentration, a linear relationship was found betwee... | [
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PMID:18939 | Glucose utilization and role of blood in endotoxin shock. | The present study was conducted to explore influences modifying glucose uptake in canine blood administered LD100 E. coli endotoxin. Particular emphasis was given to assay the role of the white blood cell (WBC) in glucose utilization. Significant increases in glucose uptake and lactic acid production, attributed to inc... | Glucose utilization and role of blood in endotoxin shock. The present study was conducted to explore influences modifying glucose uptake in canine blood administered LD100 E. coli endotoxin. Particular emphasis was given to assay the role of the white blood cell (WBC) in glucose utilization. Significant increases in gl... | [
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PMID:18941 | Role of sympathetics in the response to acute venous occlusion. | The effect of venous ligation and subsequent blockade of alpha receptors on hindlimb venous pressure, vascular resistance, oxygen extraction and carbon dioxide removal was evaluated in mongrel dogs with use of constant-flow perfusion of the extremity bed. Perfusion, metatarsal vein, femoral vein, and central vein press... | Role of sympathetics in the response to acute venous occlusion. The effect of venous ligation and subsequent blockade of alpha receptors on hindlimb venous pressure, vascular resistance, oxygen extraction and carbon dioxide removal was evaluated in mongrel dogs with use of constant-flow perfusion of the extremity bed. ... | [
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PMID:18942 | The effects of purified cathepsin D infusions in intact animals. | Cathepsin D, a potent acid proteinase, has been implicated in the pathogenesis of circulatory shock. The infusion of purified preparations of cathepsin D into intact animals resulted in significant depressions in core body temperature but failed to reproduce the cardiovascular disturbances seen in shock states. | The effects of purified cathepsin D infusions in intact animals. Cathepsin D, a potent acid proteinase, has been implicated in the pathogenesis of circulatory shock. The infusion of purified preparations of cathepsin D into intact animals resulted in significant depressions in core body temperature but failed to reprod... | [
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PMID:18953 | Acid-base status in diabetic mothers and their infants following general or spinal anesthesia for cesarean section. | Acid-base status was studied in 30 diabetic mothers and their infants and in 30 healthy mothers and their babies after general or spinal anesthesia for cesarean section. A normal acid-base state was found for the diabetic subjects following general or spinal anesthesia. However, the infants of diabetic mothers given sp... | Acid-base status in diabetic mothers and their infants following general or spinal anesthesia for cesarean section. Acid-base status was studied in 30 diabetic mothers and their infants and in 30 healthy mothers and their babies after general or spinal anesthesia for cesarean section. A normal acid-base state was found... | [
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PMID:18957 | Double-blind trial of oral carbuterol in bronchial asthma. | A double-blind comparison of 2 and 3 mg oral doses of carbuterol, a beta sympathomimetic drug with preferential selectivity for bronchial smooth muscle, was made with 25 and 35 mg doses of ephedrine sulfate over a six-month period in 26 patients with bronchial asthma. Spirometry was done before and three hours after ad... | Double-blind trial of oral carbuterol in bronchial asthma. A double-blind comparison of 2 and 3 mg oral doses of carbuterol, a beta sympathomimetic drug with preferential selectivity for bronchial smooth muscle, was made with 25 and 35 mg doses of ephedrine sulfate over a six-month period in 26 patients with bronchial ... | [
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PMID:18958 | Newer medications to aid treatment of asthma. | The selective beta-2 adrenergic bronchodilator preparations should be considered the medications for the first line of defense in the treatment of the average asthmatic patient. Theophylline and derivatives of theophylline are the second line of defense. Cromolyn sodium, atropine and derivatives, corticosteroids and ot... | Newer medications to aid treatment of asthma. The selective beta-2 adrenergic bronchodilator preparations should be considered the medications for the first line of defense in the treatment of the average asthmatic patient. Theophylline and derivatives of theophylline are the second line of defense. Cromolyn sodium, at... | [
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PMID:18961 | [Toxico-pharmacological study of lyophilized sodium nitroprusside (SNP)]. | Sodium nitroprusside (SNP) shows a strong hypotensive activity not only in normotensive animals but also in the presence of experimentally induced arterial hypertension. Its use in intravenous perfusion produces the rapid induction of arterial hypotension lasting or only slightly exceeding the time of its administratio... | [Toxico-pharmacological study of lyophilized sodium nitroprusside (SNP)]. Sodium nitroprusside (SNP) shows a strong hypotensive activity not only in normotensive animals but also in the presence of experimentally induced arterial hypertension. Its use in intravenous perfusion produces the rapid induction of arterial hy... | [
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PMID:18964 | [Use of sodium nitroprusside in cardiology]. | Sodium nitroprusside (SNP) is rarely used in cardiology. It is reserved traditionally for severe episodes of arterial hypertension. Certain states of refractory heart failure represent new indications for use, which implies a double haemodynamic monitoring system: continuous control of systemic blood pressure by intra-... | [Use of sodium nitroprusside in cardiology]. Sodium nitroprusside (SNP) is rarely used in cardiology. It is reserved traditionally for severe episodes of arterial hypertension. Certain states of refractory heart failure represent new indications for use, which implies a double haemodynamic monitoring system: continuous... | [
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PMID:18967 | [Changes in serum and urinary magnesium during and after extracorporeal circulation in cardiac surgery in children]. | Magnesium plays an essential role in the processes of myocardial contraction and conduction. In cardiovascular surgery, extracorporeal circulation (ECC) in haemodilution results in various electrolyte distrubances, with invariably hypomagnesaemia. A group of 13 children undergoing open heart surgery was compared with a... | [Changes in serum and urinary magnesium during and after extracorporeal circulation in cardiac surgery in children]. Magnesium plays an essential role in the processes of myocardial contraction and conduction. In cardiovascular surgery, extracorporeal circulation (ECC) in haemodilution results in various electrolyte di... | [
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PMID:18968 | [Action of Trivé 1000 on hemostasis and hematocrit]. | The action of lipids on haemostasis has already been shown. The authors study possible changes of haemostasis induced by the use of a substance: Trive 1000 containing 3.8 g of Soya oil and 0.3 g of Soya lecithin per 100 ml. Twenty patient received 1 litre per day over a period of ten days and were compared with 16 cont... | [Action of Trivé 1000 on hemostasis and hematocrit]. The action of lipids on haemostasis has already been shown. The authors study possible changes of haemostasis induced by the use of a substance: Trive 1000 containing 3.8 g of Soya oil and 0.3 g of Soya lecithin per 100 ml. Twenty patient received 1 litre per day ove... | [
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PMID:18969 | [Study of tracheal pressures transmitted by intubation tube balloons]. | In the light of experimental studies on balloons of several intubation tubes, the concepts of occlusive pressure, tracheal pressure and minimum occlusive volume are defined and dissociated. An in vivo study made it possible to determine the importance of the tracheal mucous pulse, the suppression of which could contrib... | [Study of tracheal pressures transmitted by intubation tube balloons]. In the light of experimental studies on balloons of several intubation tubes, the concepts of occlusive pressure, tracheal pressure and minimum occlusive volume are defined and dissociated. An in vivo study made it possible to determine the importan... | [
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PMID:18970 | [A case of gastric rupture caused by oxygen therapy by the nasal route]. | The introduction of a catheter for oxygen therapy by the pernasal route, pushed almost into the esophagus led to a gastric rupture. Discussion of this case and of 8 cases already published in the literature. | [A case of gastric rupture caused by oxygen therapy by the nasal route]. The introduction of a catheter for oxygen therapy by the pernasal route, pushed almost into the esophagus led to a gastric rupture. Discussion of this case and of 8 cases already published in the literature. | [
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PMID:18971 | [Study of a new anesthetic agent: etomidate (R 26490). Electroencephalographic aspects]. | Etomidate or R 26490 is a new hypnotic agent produced by JANSSEN and al. in 1971. The first human experimentation was performed in 1972. The authors used Etomidate for 300 anaesthetics given for neuroradiological investigations. Two protocols were used for study: 25 anaesthetics were given with Etomidate as sole anaest... | [Study of a new anesthetic agent: etomidate (R 26490). Electroencephalographic aspects]. Etomidate or R 26490 is a new hypnotic agent produced by JANSSEN and al. in 1971. The first human experimentation was performed in 1972. The authors used Etomidate for 300 anaesthetics given for neuroradiological investigations. Tw... | [
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PMID:18972 | Replication of swine and equine influenza viruses in canine kidney cells. | Both swine and equine influenza viruses were replicated in Madin-Darby canine kidney cells. Hemagglutinin and complement-fixing antigens were synthesized at 4 to 8 hours postinfection and reached maximal synthesis at 16 to 20 hours. Neuraminidase activity increased 9- to 11-fold; 50% of the total hemagglutinin antigen ... | Replication of swine and equine influenza viruses in canine kidney cells. Both swine and equine influenza viruses were replicated in Madin-Darby canine kidney cells. Hemagglutinin and complement-fixing antigens were synthesized at 4 to 8 hours postinfection and reached maximal synthesis at 16 to 20 hours. Neuraminidase... | [
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PMID:18979 | [Relationship between the quality of the inoculum material and carminomycin biosynthesis by a culture of Actinomadura carminata]. | The effect of the inoculum mycelium quality on carminomycin biosynthesis by Actinomadura carminata was studied. The time of the organism growth on the culture medium containing cornsteep liquor continued for 6 hours without losing by the inoculum of its seeding qualities during that period. The mycelium growth in the i... | [Relationship between the quality of the inoculum material and carminomycin biosynthesis by a culture of Actinomadura carminata]. The effect of the inoculum mycelium quality on carminomycin biosynthesis by Actinomadura carminata was studied. The time of the organism growth on the culture medium containing cornsteep liq... | [
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PMID:18980 | [Physicochmemical characteristics of the new antineoplastic antibiotic, nocamycin]. | Nocamycin is produced by Nocardiopsis syringae. It is recovered from the culture fluid by extraction with chloroform. The molecular weight of the crystalline antibiotic is 503, its melting point is 147--149 degrees, [alpha]20 degrees D = --50 degrees (c. 0.21, chloroform), lambdamax235 and 348 nm(E1%sm= = 150 and 420),... | [Physicochmemical characteristics of the new antineoplastic antibiotic, nocamycin]. Nocamycin is produced by Nocardiopsis syringae. It is recovered from the culture fluid by extraction with chloroform. The molecular weight of the crystalline antibiotic is 503, its melting point is 147--149 degrees, [alpha]20 degrees D ... | [
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PMID:18981 | [Effect of different forms of nitrogen in the biosynthesis of gentamicin by a Micromonospora purpurea var. violacea 1935 culture]. | The effect of different inorganic sources of reduced and oxidized nitrogen on biosynthesis of gentamicin was studied. It was shown that both the ammonium and the nitrate nitrogen were consumed by the antibiotic-producing organism. Out of all the salts tested only ammonium sulfate stimulated the biosynthesis of gentamic... | [Effect of different forms of nitrogen in the biosynthesis of gentamicin by a Micromonospora purpurea var. violacea 1935 culture]. The effect of different inorganic sources of reduced and oxidized nitrogen on biosynthesis of gentamicin was studied. It was shown that both the ammonium and the nitrate nitrogen were consu... | [
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PMID:18982 | [Ways to optimize the technological process of oleandomycin reextraction]. | Dependence of the oleandomycin distribution coefficient on pH of the acqueous phase and temperature in the system of butylacetate extract-water acidified with orthophosphoric acid was studied. With a purpose of intensification of the process of oleandomycin reextraction, decreasing the antibiotic inactivation and evapo... | [Ways to optimize the technological process of oleandomycin reextraction]. Dependence of the oleandomycin distribution coefficient on pH of the acqueous phase and temperature in the system of butylacetate extract-water acidified with orthophosphoric acid was studied. With a purpose of intensification of the process of ... | [
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PMID:18977 | Normal and abnormal middle ear ventilation. | Studies in infants and children have suggested a functional rather than mechanical obstruction of the Eustachian tube as a predisposing factor in middle ear effusions (MEE). To simulate this condition in the laboratory, an animal model was prepared using juvenile Rhesus monkeys. The tensor veli palatini muscle was tran... | Normal and abnormal middle ear ventilation. Studies in infants and children have suggested a functional rather than mechanical obstruction of the Eustachian tube as a predisposing factor in middle ear effusions (MEE). To simulate this condition in the laboratory, an animal model was prepared using juvenile Rhesus monke... | [
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PMID:18983 | [Role of the functional groups of the sibiromycin molecule in DNA binding]. | Biological activity of 2 derivatives of sibiromycin, an antibiotic close by its chemical structure to antramycin and their capacity for formation of complexes with DNA was studied. Anhydrosibiromycin like sibiromycin formed a complex with DNA. The antibiotic increased the DNA melting point but to a less extent than sib... | [Role of the functional groups of the sibiromycin molecule in DNA binding]. Biological activity of 2 derivatives of sibiromycin, an antibiotic close by its chemical structure to antramycin and their capacity for formation of complexes with DNA was studied. Anhydrosibiromycin like sibiromycin formed a complex with DNA. ... | [
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PMID:18984 | [Antibiotic sensitivity of the bacterial microflora from the sputum of children with acute pneumonia]. | Bacteriological analysis of sputum of 598 children with acute pneumonia was performed. Sensivity of 1348 cultures belonging to 8 bacterial species with respect to benzylpenicillin, streptomycin, chloramphenicol, tetracycline, oxytetracycline, chlortetracycline, erythromycin, oleandomycin, neomycin and monomycin was det... | [Antibiotic sensitivity of the bacterial microflora from the sputum of children with acute pneumonia]. Bacteriological analysis of sputum of 598 children with acute pneumonia was performed. Sensivity of 1348 cultures belonging to 8 bacterial species with respect to benzylpenicillin, streptomycin, chloramphenicol, tetra... | [
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PMID:18985 | Activity of spectinomycin against anaerobes. | The in vitro inhibitory activity of spectinomycin was tested against various anaerobic bacteria. Different results were obtained with different media and with different initial pH's of the media. The highest minimum inhibitory concentrations for Bacteroides fragilis ([Formula: see text] 128 mug/ml) were obtained with t... | Activity of spectinomycin against anaerobes. The in vitro inhibitory activity of spectinomycin was tested against various anaerobic bacteria. Different results were obtained with different media and with different initial pH's of the media. The highest minimum inhibitory concentrations for Bacteroides fragilis ([Formul... | [
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PMID:18986 | Differential susceptibility of spleen focus-forming virus and murine leukemia viruses to ansamycin antibiotics. | The streptovaricin complex (SvCx) and rifamycin SV derivatives display potent antiviral activity against the polycythemic strain of Friend leukemia virus (FV-P), as measured by a reduction in the number of spleen foci produced in mice. Such reductions may be explained by inactivation of functions of (i) the spleen focu... | Differential susceptibility of spleen focus-forming virus and murine leukemia viruses to ansamycin antibiotics. The streptovaricin complex (SvCx) and rifamycin SV derivatives display potent antiviral activity against the polycythemic strain of Friend leukemia virus (FV-P), as measured by a reduction in the number of sp... | [
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PMID:18987 | Effects of small-particle aerosols of rimantadine and ribavirin on arterial blood pH and gas tensions and lung water content of A2 influenza-infected mice. | The respiratory pathophysiology of A2 influenza infection was studied in mice treated with small-particle aerosols (SPA) of rimantadine or ribavirin. Untreated infections in mice resulted in survival rates of 15% or less and were characterized by (i) severe hypoventilation (decreased P(O2) and increased P(CO2)), (ii) c... | Effects of small-particle aerosols of rimantadine and ribavirin on arterial blood pH and gas tensions and lung water content of A2 influenza-infected mice. The respiratory pathophysiology of A2 influenza infection was studied in mice treated with small-particle aerosols (SPA) of rimantadine or ribavirin. Untreated infe... | [
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PMID:18988 | Delineation of the relative antibacterial activity of cefamandole and cefamandole nafate. | By conventional laboratory evaluation procedures, the in vitro antibacterial activities of cefamandole and its O-formyl ester, cefamandole nafate, appear virtually identical. When the activities of these two compounds were examined for their ability to lyse log-phase cultures of susceptible bacteria, however, cefamando... | Delineation of the relative antibacterial activity of cefamandole and cefamandole nafate. By conventional laboratory evaluation procedures, the in vitro antibacterial activities of cefamandole and its O-formyl ester, cefamandole nafate, appear virtually identical. When the activities of these two compounds were examine... | [
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PMID:18989 | Rapid induction of alpha-amylase by nongrowing mycelia of Aspergillus oryzae. | A rapid induction system for synthesis of alpha-amylase by the funga Aspergillus oryzae M-13 was established. The mycelia were prepared from 20-h cultures grown on a peptone-glycerol medium and starved for 5 h; maltose was the optimum inducer tested. During h 1 of induction, formation of both intra- and extracellular a... | Rapid induction of alpha-amylase by nongrowing mycelia of Aspergillus oryzae. A rapid induction system for synthesis of alpha-amylase by the funga Aspergillus oryzae M-13 was established. The mycelia were prepared from 20-h cultures grown on a peptone-glycerol medium and starved for 5 h; maltose was the optimum inducer... | [
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PMID:18990 | Effect of storage time and temperature on the survival of Clostridium botulinum spores in acid media. | Clostridium-botulinum type A and type B spores were stored in tomato juice (pH 4.2) and citric acid-phosphate buffer (pH 4.2) at 4, 22, and 32 degrees C for 180 days. The spore count was determined at different intervals over the 180-day storage period. There was no significant decrease in the number of type A spores i... | Effect of storage time and temperature on the survival of Clostridium botulinum spores in acid media. Clostridium-botulinum type A and type B spores were stored in tomato juice (pH 4.2) and citric acid-phosphate buffer (pH 4.2) at 4, 22, and 32 degrees C for 180 days. The spore count was determined at different interva... | [
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PMID:18997 | Graft-versus-host reaction. Cutaneous manifestations following bone marrow transplantation. | The distinctive cutaneous changes that occur in both the acute and chronic forms of the graft-vs-host reaction (GVHR) are described in two living patients in whom the GVHR developed after bone marrow transplantation for aplastic anemia. In the skin, the mild form of the acute GVHR is recognized as a subtle macular eryt... | Graft-versus-host reaction. Cutaneous manifestations following bone marrow transplantation. The distinctive cutaneous changes that occur in both the acute and chronic forms of the graft-vs-host reaction (GVHR) are described in two living patients in whom the GVHR developed after bone marrow transplantation for aplastic... | [
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PMID:19000 | The salt relations of Dunaliella. Further observations on glycerol production and its regulation. | Dunaliella tertiolecta (marine) and D. viridis (halophilic) were each trained by serial transfer to grow at salt concentrations previously regarded as the other's domain. D. viridis then had a salt optimum at 1.0-1.5 M sodium chloride whereas that for D. tertiolecta was less than 0-2 M. Nevertheless D. tertiolecta grew... | The salt relations of Dunaliella. Further observations on glycerol production and its regulation. Dunaliella tertiolecta (marine) and D. viridis (halophilic) were each trained by serial transfer to grow at salt concentrations previously regarded as the other's domain. D. viridis then had a salt optimum at 1.0-1.5 M sod... | [
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PMID:19001 | [Studies on the thiamine transport system in Bacillus cereus (author's transl)]. | The thiamine transport system in Bacillus cereus exhibits rhythmical changes of resorption- and excretion-phases lasting 1-2 h. These main phases are subdivided in shorter ones with an average duration of 45 s. The velocity of the thiamine uptake is influenced by pH, temperature, age of cells, energy and substrate supp... | [Studies on the thiamine transport system in Bacillus cereus (author's transl)]. The thiamine transport system in Bacillus cereus exhibits rhythmical changes of resorption- and excretion-phases lasting 1-2 h. These main phases are subdivided in shorter ones with an average duration of 45 s. The velocity of the thiamine... | [
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PMID:18998 | Nitrogen dioxide and pulmonary proteolytic enzymes. Effect on lung tissue and macrophages. | Hamsters were exposed to 30 ppm nitrogen dioxide (NO2) for 2 and 50 days and sacrificed. Pulmonary lavage was carried out on a portion of each group to obtain an alveolar macrophage fraction. Proteolytic activity (P.A.), as measured by caseinolysis at pH 3.0 and pH 5.0, increased nearly twofold in the 2-day NO2 lung ex... | Nitrogen dioxide and pulmonary proteolytic enzymes. Effect on lung tissue and macrophages. Hamsters were exposed to 30 ppm nitrogen dioxide (NO2) for 2 and 50 days and sacrificed. Pulmonary lavage was carried out on a portion of each group to obtain an alveolar macrophage fraction. Proteolytic activity (P.A.), as measu... | [
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PMID:19002 | Utilization of nitrogen compounds and ammonia assimilation by Chromatiaceae. | Chromatium vinosum strain D, Thiocapsa roseopersicina strain 6311 and Ectothiorhodospira mobilis strain 8112 were grown anaerobically in the light with various single nitrogen sources. When substituted for NH4Cl only glutamine and casamino acids supported good growth of all strains tested. Peptone and urea were utilize... | Utilization of nitrogen compounds and ammonia assimilation by Chromatiaceae. Chromatium vinosum strain D, Thiocapsa roseopersicina strain 6311 and Ectothiorhodospira mobilis strain 8112 were grown anaerobically in the light with various single nitrogen sources. When substituted for NH4Cl only glutamine and casamino aci... | [
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PMID:19004 | Substitute and alternative neurotransmitters in neuropsychiatric illness. | The accumulation of structural analogs of normal synaptic neurotransmitters (substitute or "false" neurotransmitters) can have profound behavioral and neurologic consequences. Such abnormalities of the metabolism of amines and amino acids may explain behavioral and neurologic changes in hepatic failure. Accumulations o... | Substitute and alternative neurotransmitters in neuropsychiatric illness. The accumulation of structural analogs of normal synaptic neurotransmitters (substitute or "false" neurotransmitters) can have profound behavioral and neurologic consequences. Such abnormalities of the metabolism of amines and amino acids may exp... | [
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PMID:19005 | [Aminoacid-p-nitroanilides splitting activities in the mature human placenta (author's transl)]. | A long experience in the treatment of endometrial cancer shows that the therapeutic measures vary considerably with regard to the extention of the tumor, the age of the patient and her general condition. This circumstances and particularly the critical study of the therapeutical results give the limits, within a certai... | [Aminoacid-p-nitroanilides splitting activities in the mature human placenta (author's transl)]. A long experience in the treatment of endometrial cancer shows that the therapeutic measures vary considerably with regard to the extention of the tumor, the age of the patient and her general condition. This circumstances ... | [
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PMID:19006 | [Aminoacid-p-nitroanilides splitting activities in the mouse human placenta (author's transl)]. | Proteolytic activities of human placental extract are determined with the aid of a sensitive micromethod, based upon the Bratton-Marshall-reaction, and aminoacid-p-nitroanilides as substrates. The activities are differentiated by using 19 substrates, by adding 10 effectors, and by incubating the assays within the pH-ra... | [Aminoacid-p-nitroanilides splitting activities in the mouse human placenta (author's transl)]. Proteolytic activities of human placental extract are determined with the aid of a sensitive micromethod, based upon the Bratton-Marshall-reaction, and aminoacid-p-nitroanilides as substrates. The activities are differentiat... | [
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... |
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