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medium_divergent_branch_05422 | The gene GLB1L is enriched in multiple cell types. One specific enrichment profile is characterized by a mean expression of 6.41 TPM, a z-score of 1.91, and a fold enrichment of 3.70. Identify the cell type associated with this specific expression profile, and then determine the cell type from which it develops. | classical monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05422","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene GLB1L is enriched in multiple cell types. One specific enrichment profile is characterized by a mean expression of 6.41 TPM, a z-score of 1.... | |
medium_divergent_branch_05424 | HBEGF interacts with multiple genes. One specific interaction is characterized by the nuclear translocation of HB-EGF-CTF, which leads to its interaction with the target protein, subsequent nuclear export of that protein, and its degradation via the ubiquitin/proteasome pathway. Which protein is encoded by the gene inv... | B-cell lymphoma 6 protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05424","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HBEGF interacts with multiple genes. One specific interaction is characterized by the nuclear translocation of HB-EGF-CTF, which leads to its interac... | |
medium_divergent_branch_05425 | The gene RGCC interacts with multiple partners. One specific interaction is supported by evidence that RGC-32 was physically associated with cyclin-dependent kinase p34CDC2 and increased its kinase activity in vivo and in vitro. Which disease is connected to this specific interacting partner through genomic alterations... | enterovirus infectious disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05425","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene RGCC interacts with multiple partners. One specific interaction is supported by evidence that RGC-32 was physically associated with cyclin-d... | |
medium_divergent_branch_05426 | UBQLN1 interacts with multiple proteins. Evidence for one of these interactions indicates that the binding is not dependent on STI domains and is not stabilized by UBQLN1, specifically citing a UBL-mediated interaction involving the target protein and PSMD4. Which protein, connected to UBQLN1 via an interaction, is enc... | Large proline-rich protein BAG6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05426","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBQLN1 interacts with multiple proteins. Evidence for one of these interactions indicates that the binding is not dependent on STI domains and is not... | |
medium_divergent_branch_05428 | TADA3 interacts with multiple proteins. One specific interaction is described as occurring between the conserved C-terminal domain of ANCO-1 and the N-terminal transactivation domain of ADA3. Which protein, encoded by the gene connected to TADA3 via this specific interaction, is the subject of the query? | Ankyrin repeat domain-containing protein 12 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05428","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TADA3 interacts with multiple proteins. One specific interaction is described as occurring between the conserved C-terminal domain of ANCO-1 and the ... | |
medium_divergent_branch_05429 | PPP1CA interacts with multiple regulatory subunits. One specific interaction involves a partner that binds to protein phosphatase PP1 and attenuates the translational elongation of key transcriptional factors through the dephosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha). Which disease is associated w... | tuberous sclerosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05429","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PPP1CA interacts with multiple regulatory subunits. One specific interaction involves a partner that binds to protein phosphatase PP1 and attenuates ... | |
medium_divergent_branch_05430 | UBE2I interacts with multiple genes. One of these interacting partners is described as a protein that interacts with the SUMO E2 enzyme UBC9 and inhibits UBC9's ability to transfer SUMO to target proteins. Which disease is associated with this specific interacting partner via a biomarker relationship? | gastric carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05430","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBE2I interacts with multiple genes. One of these interacting partners is described as a protein that interacts with the SUMO E2 enzyme UBC9 and inhi... | |
medium_divergent_branch_05432 | ATRX interacts with multiple genes. One of these interaction partners is characterized by the following evidence: 'By employing peptide arrays, chromatin pull-down and peptide binding assays, we show specific binding of the ADD domain to H3 histone tail peptides containing H3K9me3.' Which disease is associated with thi... | squamous cell lung carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05432","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATRX interacts with multiple genes. One of these interaction partners is characterized by the following evidence: 'By employing peptide arrays, chrom... | |
medium_divergent_branch_05433 | FBXL7 interacts with multiple genes. One of these interaction partners is a protein that FBXL7 targets for polyubiquitylation and proteasomal degradation by binding to Glu-126 within its carboxyl-terminal α helix. Which disease is associated with genomic alterations in this specific interaction partner? | asthma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05433","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXL7 interacts with multiple genes. One of these interaction partners is a protein that FBXL7 targets for polyubiquitylation and proteasomal degrada... | |
medium_divergent_branch_05434 | SUPT4H1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Immunodepletion of hSpt5 from HeLa nuclear extracts resulted in the efficient co-depletion of hSpt4.' Which protein product is encoded by the gene corresponding to the interacting partner described in this evidence? | Transcription elongation factor SPT5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05434","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SUPT4H1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Immunodepletion of hSpt5 from HeLa nuclear extracts resu... | |
medium_divergent_branch_05435 | The protein ACTA1 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating: 'We show that non-mutated actin produced in the BEVS behaves similarly to native actin, as shown by DNase I affinity purification, Western blotting, and consecutive cycl... | polymeric cytoskeletal fiber | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05435","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein ACTA1 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating... | |
medium_divergent_branch_05436 | ANK1 interacts with multiple genes. One interaction is supported by evidence stating: 'We found that the hydrophilic cytoplasmic domain of sAnk1 interacted with the two most N-terminal Ig domains of the interaction partner, ZIg1 and ZIg2, which are present at the Z-line in situ.' Which disease is connected to this inte... | spinal muscular atrophy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05436","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ANK1 interacts with multiple genes. One interaction is supported by evidence stating: 'We found that the hydrophilic cytoplasmic domain of sAnk1 inte... | |
medium_divergent_branch_05437 | MYC interacts with multiple proteins. Evidence for one of these interactions states: 'High-density CRISPR gene body scan pinpoints the critical MYC interacting residue in this protein.' Which protein, encoded by the gene connected to MYC via this specific interaction, is the target described in the evidence? | RuvB-like 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05437","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MYC interacts with multiple proteins. Evidence for one of these interactions states: 'High-density CRISPR gene body scan pinpoints the critical MYC i... | |
medium_divergent_branch_05438 | TAF8 interacts with multiple proteins. One interaction is characterized by the formation of a heterodimer mediated by HF and proline-rich domains. Which protein, encoded by the gene connected to TAF8 via this specific interaction, is the subject of this description? | Transcription initiation factor TFIID subunit 10 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05438","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TAF8 interacts with multiple proteins. One interaction is characterized by the formation of a heterodimer mediated by HF and proline-rich domains. Wh... | |
medium_divergent_branch_05439 | The gene ITK interacts with multiple partners via binding. One specific interaction is supported by evidence stating: 'Here we report a TCR/CD3-regulated association between Emt and PLC gamma 1 in both normal and leukemic T cells.' Based on this evidence, which disease is associated with the identified interacting gene... | bipolar disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05439","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ITK interacts with multiple partners via binding. One specific interaction is supported by evidence stating: 'Here we report a TCR/CD3-regul... | |
medium_divergent_branch_05442 | KLHL29 interacts with multiple proteins. One of these interactions is characterized by the mechanism where KLHL29 recruits the CUL3 E3-ligase to an RNA-binding protein, leading to the proteasomal degradation of that protein. Which protein, connected to KLHL29 via this specific interaction, is encoded by the gene in que... | ATP-dependent RNA helicase DDX3X | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05442","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KLHL29 interacts with multiple proteins. One of these interactions is characterized by the mechanism where KLHL29 recruits the CUL3 E3-ligase to an R... | |
medium_divergent_branch_05443 | The gene IFIH1 interacts with multiple other genes. One of these interacting partners is known to be associated with RIG-I and MDA5 and functions in two distinct processes for the regulation of RIG-I and MDA5 activities. Which protein is encoded by this specific interacting gene? | Zinc finger CCHC domain-containing protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05443","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene IFIH1 interacts with multiple other genes. One of these interacting partners is known to be associated with RIG-I and MDA5 and functions in ... | |
medium_divergent_branch_05444 | Caffeine interacts with multiple drugs. One of these interacting drugs is known to inhibit CYP1A2 activity, a property shared by fluvoxamine, quinolone antibiotics, verapamil, and oral contraceptives. Which disease is this specific interacting drug indicated for? | peptic ulcer disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05444","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Caffeine interacts with multiple drugs. One of these interacting drugs is known to inhibit CYP1A2 activity, a property shared by fluvoxamine, quinolo... | |
medium_divergent_branch_05445 | CXXC1 interacts with multiple genes. One of these interacting partners is part of the Setd1 histone H3-Lys4 methyltransferase complexes, and a point mutation (C375A) in CXXC1 abolishes this interaction, thereby abating the rescue activity of the Cfp1(361-656) fragment. Which disease is associated with this specific int... | intellectual developmental disorder with seizures and language delay | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05445","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CXXC1 interacts with multiple genes. One of these interacting partners is part of the Setd1 histone H3-Lys4 methyltransferase complexes, and a point ... | |
medium_divergent_branch_05447 | TICAM1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In yeast two-hybrid screens, we identified TNF receptor-associated factor (TRAF)1 as a TRIF-interacting protein.' Note that TRIF is an alias for TICAM1. Which protein, connected to TICAM1 via this specific interaction evidence, ... | TNF receptor-associated factor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05447","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TICAM1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In yeast two-hybrid screens, we identified TNF receptor-a... | |
medium_divergent_branch_05448 | Motor neurons are anatomically part of specific structures. One such structure is characterized by subclasses of motor neurons organized into longitudinally oriented columns that occupy distinct and, in some cases, discontinuous domains along the rostrocaudal axis of the spinal cord, where neurons within a single colum... | spinal cord column | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05448","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Motor neurons are anatomically part of specific structures. One such structure is characterized by subclasses of motor neurons organized into longitu... | |
medium_divergent_branch_05449 | SLC27A2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Studies using a yeast two hybrid system and surface plasmon resonance techniques indicate that a peroxisomal membrane protein, physically interacts with VLCS.' Which protein, connected to SLC27A2 via this specific interaction e... | ATP-binding cassette sub-family D member 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05449","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SLC27A2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Studies using a yeast two hybrid system and surface plas... | |
medium_divergent_branch_05450 | Human respirovirus 3 upregulates multiple genes. One such gene exhibits a log2 fold change of 2.733 and an adjusted p-value of 0.04933 in non-small cell lung adenocarcinoma cell lines (study GSE147507). Which disease is associated with this specific gene via a biomarker relationship? | Huntington disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05450","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Human respirovirus 3 upregulates multiple genes. One such gene exhibits a log2 fold change of 2.733 and an adjusted p-value of 0.04933 in non-small c... | |
medium_divergent_branch_05451 | Clusterin (CLU) interacts with multiple proteins. One interaction is characterized by the following evidence: 'These motifs enable semen clusterin to bind a C-type lectin receptor with very high affinity (K(d) 76 nM) and abrogate the binding of HIV-1 to this receptor.' Which protein, encoded by the gene interacting wit... | CD209 antigen | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05451","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Clusterin (CLU) interacts with multiple proteins. One interaction is characterized by the following evidence: 'These motifs enable semen clusterin to... | |
medium_divergent_branch_05452 | CCDC14 interacts with multiple proteins. One of these interaction partners is characterized by evidence stating that both proteins colocalize with the partner to satellites, bind to the partner, and identify other satellite proteins by BioID. Which protein product is encoded by the gene corresponding to this specific i... | Centrosomal protein of 63 kDa | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05452","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CCDC14 interacts with multiple proteins. One of these interaction partners is characterized by evidence stating that both proteins colocalize with th... | |
medium_divergent_branch_05454 | DLG4 interacts with multiple genes. One of these interaction partners is described in a study stating: 'In this study, we demonstrate that the protein is enriched in the adult mouse brain and associated with PSD-95 isoforms containing PDZ (PSD-95/DLG/ZO-1) domains, such as PSD-95/SAP90, PSD-93/chapsin110, and SAP97/DLG... | extracellular space | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05454","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DLG4 interacts with multiple genes. One of these interaction partners is described in a study stating: 'In this study, we demonstrate that the protei... | |
medium_divergent_branch_05456 | SKP1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we report that beta-TrCP is the F-box protein that targets phosphorylated [protein] for degradation by the Skp1/Cul1/F-box protein complex.' Which protein, connected to SKP1 via an interaction, is the subject of this specific... | M-phase inducer phosphatase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05456","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SKP1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we report that beta-TrCP is the F-box protein that tar... | |
medium_divergent_branch_05459 | GRB10 interacts with multiple proteins. One specific interaction was identified using a yeast two-hybrid screen where the cytoplasmic tail of a receptor tyrosine kinase served as bait and a mouse embryo cDNA library as prey, revealing that the SH2 domain of GRB10 binds to this kinase. Which cellular component is the lo... | extracellular space | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05459","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GRB10 interacts with multiple proteins. One specific interaction was identified using a yeast two-hybrid screen where the cytoplasmic tail of a recep... | |
medium_divergent_branch_05461 | FOXM1 interacts with multiple genes. One interaction is supported by evidence stating: 'We show that the retinoblastoma protein binds to the C-terminal activation domain of FoxM1b.' Which cell type is the gene involved in this specific interaction enriched in? | naive B cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05461","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXM1 interacts with multiple genes. One interaction is supported by evidence stating: 'We show that the retinoblastoma protein binds to the C-termin... | |
medium_divergent_branch_05462 | The FES protein is associated with multiple biological processes. One specific association is supported by evidence stating that FES is involved in monocytic differentiation via the upregulation of PU.1 and MCSFR. Which biological process, connected to the process described by this evidence, is linked to it via a 'posi... | monocyte differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05462","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The FES protein is associated with multiple biological processes. One specific association is supported by evidence stating that FES is involved in m... | |
medium_divergent_branch_05463 | ABCA2 is involved in multiple biological processes. One of these processes is supported by evidence linking ABCA2 expression levels to changes in cholesterol and sphingolipid metabolism. Which biological process is a parent term (via 'is a') of the process supported by this evidence? | regulation of lipid metabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05463","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ABCA2 is involved in multiple biological processes. One of these processes is supported by evidence linking ABCA2 expression levels to changes in cho... | |
medium_divergent_branch_05464 | ITSN1 interacts with multiple genes. Evidence for one of these interactions indicates that Intersectin and the partner protein are co-enriched in nerve terminals and are co-immunoprecipitated from brain extracts. Which gene is connected to ITSN1 through this interaction? | COPS3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05464","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ITSN1 interacts with multiple genes. Evidence for one of these interactions indicates that Intersectin and the partner protein are co-enriched in ner... | |
medium_divergent_branch_05465 | The gene MTNR1B is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by the following evidence: 'We now report the cloning of a second G protein-coupled melatonin receptor from humans and designate it the Mel1b melatonin receptor.' Identify the molecular ... | G protein-coupled receptor activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05465","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene MTNR1B is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by the followin... | |
medium_divergent_branch_05466 | PPP2R3A interacts with multiple genes. One interaction is supported by evidence stating: 'Two functional EF-hand calcium-binding motifs mediate a calcium-enhanced interaction of PR70 with PP2A.' Which disease is associated with the gene identified by this specific evidence through genomic alterations? | soft tissue sarcoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05466","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PPP2R3A interacts with multiple genes. One interaction is supported by evidence stating: 'Two functional EF-hand calcium-binding motifs mediate a cal... | |
medium_divergent_branch_05467 | ZEB2 is associated with multiple biological processes. One association is supported by evidence stating: 'Here we show that mice lacking Zeb2 in the melanocyte lineage exhibit a melanoblast migration defect.' Which biological process is a parent term (via 'is a') of the process described by this evidence? | epithelial cell migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05467","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZEB2 is associated with multiple biological processes. One association is supported by evidence stating: 'Here we show that mice lacking Zeb2 in the ... | |
medium_divergent_branch_05468 | The intervertebral disk of the lumbar vertebra is a type of anatomy that connects to a broader anatomical category via an 'is a' relationship. Evidence for this connection describes the entity as part of the lumbar region of the vertebral column, noting that it connects at least one lumbar vertebra to another vertebra ... | abdominal segment of trunk | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05468","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The intervertebral disk of the lumbar vertebra is a type of anatomy that connects to a broader anatomical category via an 'is a' relationship. Eviden... | |
medium_divergent_branch_05470 | The gene ATF5 is significantly enriched in multiple immune cell types. One specific cell type shows a mean expression of 26.93 TPM, a z-score of 2.32, and a fold enrichment of 7.64. What is the broader cell lineage category (parent class) of this specific cell type? | dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05470","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ATF5 is significantly enriched in multiple immune cell types. One specific cell type shows a mean expression of 26.93 TPM, a z-score of 2.32... | |
medium_divergent_branch_05471 | WSB1 interacts with multiple proteins. Evidence indicates that WSB-1, an E3 ubiquitin ligase, was characterized as interacting with a specific partner protein. Which protein, encoded by the gene connected to WSB1 via this interaction, is the subject of this characterization? | Homeodomain-interacting protein kinase 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05471","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WSB1 interacts with multiple proteins. Evidence indicates that WSB-1, an E3 ubiquitin ligase, was characterized as interacting with a specific partne... | |
medium_divergent_branch_05472 | Rift Valley fever phlebovirus downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.456 and an adjusted p-value of 0.0274. Which protein does that selected gene encode? | E3 ubiquitin-protein ligase pellino homolog 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05472","source_qa_id":"medium_divergent_branch_07002","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Rift Valley fever phlebovirus downregulates several genes. In the recorded experiment, one bra... | |
medium_divergent_branch_05473 | The gene CBLC interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, we identify a new Cbl-c interacting protein, [Interaction Partner].' Which protein is encoded by the gene corresponding to this interaction partner? | PDZ and LIM domain protein 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05473","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CBLC interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study, we identify a new Cbl-c interacting... | |
medium_divergent_branch_05474 | DAPK2 is involved in multiple biological processes. One of these processes is supported by evidence stating: 'The defect in chemotaxis in DAPK2-inactive granulocytes is likely a result of reduced polarization of the cells, mediated by a lack of MLC phosphorylation, resulting in radial F-actin and pseudopod formation.' ... | eosinophil chemotaxis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05474","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DAPK2 is involved in multiple biological processes. One of these processes is supported by evidence stating: 'The defect in chemotaxis in DAPK2-inact... | |
medium_divergent_branch_05475 | The BLM protein interacts with multiple partners. One specific interaction is supported by evidence stating: 'Here, we report that analogous to WRN, BLM also binds to the tumor suppressor protein in vivo and in vitro, and the C-terminal domain of the tumor suppressor protein is responsible for the interaction.' Which d... | inflammatory disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05475","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The BLM protein interacts with multiple partners. One specific interaction is supported by evidence stating: 'Here, we report that analogous to WRN, ... | |
medium_divergent_branch_05476 | PDX1 interacts with multiple proteins. One of these interaction partners is an E3-ubiquitin ligase adaptor protein that binds PDX1, thereby triggering its ubiquitination and proteasomal degradation. Which protein is encoded by the gene corresponding to this specific interaction partner? | Speckle-type POZ protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05476","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PDX1 interacts with multiple proteins. One of these interaction partners is an E3-ubiquitin ligase adaptor protein that binds PDX1, thereby triggerin... | |
medium_divergent_branch_05477 | MAPK1 interacts with multiple proteins. One such interaction involves a protein that blocks ERK-dependent transcription and proliferation by binding ERKs and preventing their nuclear localization. Which cellular component is this specific interacting protein located in? | microtubule associated complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05477","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAPK1 interacts with multiple proteins. One such interaction involves a protein that blocks ERK-dependent transcription and proliferation by binding ... | |
medium_divergent_branch_05478 | PPP6C interacts with multiple proteins. One of these interaction partners is characterized by evidence stating that mutation of three basic amino acids within its phospho-serine- and phospho-threonine-binding domain prevents its interaction with MST1 and PP6 in cells treated with okadaic acid. Which protein is encoded ... | MOB kinase activator 1B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05478","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PPP6C interacts with multiple proteins. One of these interaction partners is characterized by evidence stating that mutation of three basic amino aci... | |
medium_divergent_branch_05479 | IRF4 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Stable expression of IRF-4 in Jurkat T cells not only leads to a strong enhancement in the synthesis of interleukin (IL)-2, but also enables these cells to start producing considerable amounts of IL-4, IL-... | interleukin-13 production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05479","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IRF4 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Stable expression of IRF-4 in Jurk... | |
medium_divergent_branch_05480 | BACE1 interacts with multiple proteins. One interaction is supported by evidence stating that the N-terminal half of RanBP9, containing SPRY-LisH domains, interacts with LRP as well as the protein in question and BACE1. Which protein, encoded by the gene connected to BACE1 via this interaction, is the subject of this e... | Amyloid-beta precursor protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05480","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BACE1 interacts with multiple proteins. One interaction is supported by evidence stating that the N-terminal half of RanBP9, containing SPRY-LisH dom... | |
medium_divergent_branch_05481 | PARL is associated with multiple biological processes. One specific association is supported by evidence stating that PARL preserves mitochondrial membrane homeostasis via STARD7 processing and acts as a critical regulator of protein localization between mitochondria and the cytosol. Which biological process, connected... | protein localization to mitochondrion | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05481","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PARL is associated with multiple biological processes. One specific association is supported by evidence stating that PARL preserves mitochondrial me... | |
medium_divergent_branch_05482 | ZFP36 is associated with multiple biological processes. One association is supported by evidence stating: 'In addition, we demonstrate that both ZFP36 and ZFP36L1 influence keratinocyte cell cycle, differentiation, and apoptosis in a distinct manner.' Which biological process, connected to ZFP36 via an 'involved in' re... | regulation of epithelial cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05482","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZFP36 is associated with multiple biological processes. One association is supported by evidence stating: 'In addition, we demonstrate that both ZFP3... | |
medium_divergent_branch_05483 | DOCK2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found Wnt5a could induce the target protein to complex with DOCK2 (dedicator of cytokinesis 2) and induce activation of Rac1/2; these effects could be blocked by cirmtuzumab, a humanized anti-target protein monoclonal antibody... | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05483","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DOCK2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found Wnt5a could induce the target protein to complex ... | |
medium_divergent_branch_05484 | NACC1 interacts with multiple genes. One of these interacting partners is reported to be physically associated with endogenous NAC1 in central nervous system regions. Which disease is linked to this specific interacting gene through genomic alterations? | gonorrhea | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05484","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NACC1 interacts with multiple genes. One of these interacting partners is reported to be physically associated with endogenous NAC1 in central nervou... | |
medium_divergent_branch_05486 | Primate erythroparvovirus 1 upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.372 and an adjusted p-value of 0.0416. For which disease is that selected gene recorded as a biomarker? | vitiligo | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05486","source_qa_id":"medium_divergent_branch_00470","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Primate erythroparvovirus 1 upregulates several genes. In the recorded experiment, one branch ... | |
medium_divergent_branch_05487 | RAB6A interacts with multiple proteins. One interaction is supported by evidence stating that the SHD domain of a specific protein preferentially interacted with the GTP-bound form of Rab27A and marginally with Rab3A and RAB6A, both in vitro and in intact cells. Which protein is encoded by the gene corresponding to thi... | Synaptotagmin-like protein 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05487","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAB6A interacts with multiple proteins. One interaction is supported by evidence stating that the SHD domain of a specific protein preferentially int... | |
medium_divergent_branch_05488 | PLIN2 interacts with multiple genes. One specific interaction is characterized by the following mechanism: interactions between the partner protein and PLIN2 abrogate TEB4-mediated PLIN2 ubiquitination and consequent degradation, thereby maintaining higher PLIN2 expression levels. Which disease is associated with this ... | thymoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05488","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PLIN2 interacts with multiple genes. One specific interaction is characterized by the following mechanism: interactions between the partner protein a... | |
medium_divergent_branch_05489 | RFWD3 interacts with multiple genes. One of these interaction partners is described as being physically associated with RPA and rapidly localizing to sites of DNA damage in an RPA-dependent manner. Which cellular component is this specific interaction partner located in? | DNA replication factor A complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05489","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RFWD3 interacts with multiple genes. One of these interaction partners is described as being physically associated with RPA and rapidly localizing to... | |
medium_divergent_branch_05490 | NR5A2 interacts with multiple genes. One of these interaction partners is a protein that specifically interacts and co-localizes with SIRT1 in vivo, where inhibition of SIRT1 activity leads to a recovery from the intrinsic repressive activity of this protein, but not of DAX1. Which protein is encoded by the gene connec... | Nuclear receptor subfamily 0 group B member 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05490","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NR5A2 interacts with multiple genes. One of these interaction partners is a protein that specifically interacts and co-localizes with SIRT1 in vivo, ... | |
medium_divergent_branch_05491 | ARFIP1 interacts with multiple proteins. One interaction is supported by evidence stating that the addition of myristoylated versions of the interacting protein increases the association of ARFIP1 with membranes, suggesting that ARFIP1 and this protein form a complex on the Golgi. Which protein, connected to ARFIP1 via... | ADP-ribosylation factor 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05491","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARFIP1 interacts with multiple proteins. One interaction is supported by evidence stating that the addition of myristoylated versions of the interact... | |
medium_divergent_branch_05492 | CSF1R is associated with multiple biological processes. One association is supported by evidence showing that muIL-34 and a muIL-34 isoform lacking Q81 stimulated mouse macrophage proliferation, CSF-1R tyrosine phosphorylation, and signaling. Which biological process is a parent term (via 'is a') of the process linked ... | cell surface receptor signaling pathway | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05492","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CSF1R is associated with multiple biological processes. One association is supported by evidence showing that muIL-34 and a muIL-34 isoform lacking Q... | |
medium_divergent_branch_05493 | Vigabatrin interacts with multiple drugs. One of these interacting partners is an immunotherapy agent for which hepatic metabolism is cited as the primary site of interaction, alongside other agents such as ACTH, hydrocortisone, methylprednisolone, cyclophosphamide, methotrexate, and rituximab. Which disease is the sel... | acute otitis externa | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05493","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Vigabatrin interacts with multiple drugs. One of these interacting partners is an immunotherapy agent for which hepatic metabolism is cited as the pr... | |
medium_divergent_branch_05494 | TRAF5 interacts with multiple genes. One interaction is supported by evidence stating that the interacting partner, along with TRAF2, interacted with the D2 subdomain of the protein encoded by TNFRSF8 in vitro and in vivo. Which protein is encoded by the gene connected to TRAF5 through this specific interaction? | Tumor necrosis factor receptor superfamily member 8 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05494","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRAF5 interacts with multiple genes. One interaction is supported by evidence stating that the interacting partner, along with TRAF2, interacted with... | |
medium_divergent_branch_05495 | SAMSN1 interacts with multiple proteins. One of these interaction partners is described in the context: 'In the nucleus, SLy2 interacts with the [protein]/HDAC1 complex and regulates the activity of HDAC1.' Which protein, encoded by the gene connected to SAMSN1 via an interaction, is this partner? | Histone deacetylase complex subunit SAP30 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05495","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SAMSN1 interacts with multiple proteins. One of these interaction partners is described in the context: 'In the nucleus, SLy2 interacts with the [pro... | |
medium_divergent_branch_05496 | BTLA is associated with multiple molecular functions via the 'enables' relationship. One specific connection is supported by evidence stating that HVEM induced BTLA tyrosine phosphorylation and the association of the tyrosine phosphatase SHP-2, thereby repressing antigen-driven T cell proliferation; this process serves... | molecular transducer activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05496","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BTLA is associated with multiple molecular functions via the 'enables' relationship. One specific connection is supported by evidence stating that HV... | |
medium_divergent_branch_05497 | SYK is involved in multiple biological processes. One of these processes is supported by evidence stating that inhibition of the SYK pathway leads to a consistent decrease in superoxide anion production, but not nitric oxide production. Which biological process is positively regulated by this specific SYK-associated pr... | superoxide anion generation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05497","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SYK is involved in multiple biological processes. One of these processes is supported by evidence stating that inhibition of the SYK pathway leads to... | |
medium_divergent_branch_05498 | ATF5 interacts with multiple genes. Evidence for one of these interactions comes from a yeast-based genetic assay designed to identify proteins interacting with a specific human protein. This assay identified three cDNAs encoding bZIP DNA binding motifs. Two of these interactants are repressors of cyclic AMP (cAMP)-ind... | colon carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05498","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATF5 interacts with multiple genes. Evidence for one of these interactions comes from a yeast-based genetic assay designed to identify proteins inter... | |
medium_divergent_branch_05500 | AKTIP interacts with multiple genes. One of these interaction partners is characterized by its ability to interact with telomeric DNA and bind the shelterin components TRF1 and a specific telomere-binding protein both in vivo and in vitro. Which disease is associated with this specific gene via a biomarker relationship... | adult T-cell leukemia/lymphoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05500","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AKTIP interacts with multiple genes. One of these interaction partners is characterized by its ability to interact with telomeric DNA and bind the sh... | |
medium_divergent_branch_05501 | CD68 is enriched in multiple cell types. One of these cell types exhibits a mean expression of 2962.82 TPM, a z-score of 1.53, and a fold enrichment of 5.91 for CD68. Which cell type does this specific CD68-enriched cell develop from? | intermediate monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05501","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD68 is enriched in multiple cell types. One of these cell types exhibits a mean expression of 2962.82 TPM, a z-score of 1.53, and a fold enrichment ... | |
medium_divergent_branch_05502 | IRAK1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Whereas the Pellino proteins cause polyubiquitination of IRAK-1, we also show that kinase-active members of the IRAK family (IRAK-1 and IRAK-4) promote reciprocal polyubiquitination of the Pellino proteins and that this is associ... | E3 ubiquitin-protein ligase pellino homolog 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05502","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IRAK1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Whereas the Pellino proteins cause polyubiquitination of I... | |
medium_divergent_branch_05503 | DAB2IP interacts with multiple proteins. One interaction partner is characterized by evidence stating: 'The interactions with TRAF2 and a specific mitogen-activated protein kinase kinase kinase do not occur with AIP1-S604A, suggesting that phosphorylation at this site not only creates a 14-3-3-binding site but also ope... | Mitogen-activated protein kinase kinase kinase 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05503","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DAB2IP interacts with multiple proteins. One interaction partner is characterized by evidence stating: 'The interactions with TRAF2 and a specific mi... | |
medium_divergent_branch_05504 | The gene SCN3B is associated with multiple biological processes. One specific association is supported by experimental evidence showing that co-expression of Nav1.5 with the Navbeta3-V54G variant in HEK-293 and COS cells leads to a significant decrease in peak sodium current and a positive shift in inactivation compare... | regular ventricular cardiac myocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05504","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SCN3B is associated with multiple biological processes. One specific association is supported by experimental evidence showing that co-expre... | |
medium_divergent_branch_05505 | The gene C12orf57 is associated with multiple biological processes. One specific association is supported by the evidence: 'Our data suggest that this conserved gene is required for development of the human corpus callosum.' Identify the biological process described by this evidence, and then determine the parent biolo... | central nervous system projection neuron axonogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05505","source_qa_id":"medium_divergent_branch_06001","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene C12orf57 is associated with multiple biological processes. One specific association is s... | |
medium_divergent_branch_05506 | OST4 interacts with multiple proteins. One interaction is supported by evidence stating: 'Co-immunoprecipitation studies suggest that OST4 associates with both STT3 isoforms and with ribophorin I, an accessory subunit of mammalian OSTs.' Which disease is associated with the gene identified by this evidence? | STT3B-congenital disorder of glycosylation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05506","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"OST4 interacts with multiple proteins. One interaction is supported by evidence stating: 'Co-immunoprecipitation studies suggest that OST4 associates... | |
medium_divergent_branch_05507 | NCOA4 interacts with multiple proteins. One of these interaction partners binds directly to NCOA4 and is required for the lysosomal trafficking of ferritin under both basal and iron-depleted conditions. Which protein corresponds to this interaction partner? | Tax1-binding protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05507","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NCOA4 interacts with multiple proteins. One of these interaction partners binds directly to NCOA4 and is required for the lysosomal trafficking of fe... | |
medium_divergent_branch_05511 | RAG1 is associated with multiple biological processes. One specific process requires both RAG1 and RAG2 proteins, yet recent mutational analyses indicate that the catalytic residues of the V(D)J recombinase complex are exclusively located within RAG1. Which broader biological category is this specific process a subclas... | somatic diversification of immune receptors via germline recombination within a single locus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05511","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAG1 is associated with multiple biological processes. One specific process requires both RAG1 and RAG2 proteins, yet recent mutational analyses indi... | |
medium_divergent_branch_05512 | NDNF is associated with multiple biological processes. One association is supported by evidence that NDNF promoted endothelial cell network formation and survival in vitro through activation of Akt/endothelial NOS (eNOS) signaling involving integrin αvβ3. Which biological process, connected to the process described by ... | blood vessel morphogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05512","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NDNF is associated with multiple biological processes. One association is supported by evidence that NDNF promoted endothelial cell network formation... | |
medium_divergent_branch_05514 | CMTR1 interacts with multiple genes. One of these interaction partners is characterized in a study describing hMTr1 interactions, where it is identified as an RNA-independent interactor alongside PRMT5, FXR1, and NPM1. Which cell type is this specific interaction partner enriched in? | eosinophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05514","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CMTR1 interacts with multiple genes. One of these interaction partners is characterized in a study describing hMTr1 interactions, where it is identif... | |
medium_divergent_branch_05515 | RIG-I interacts with multiple proteins. One specific interaction involves a partner whose carboxy-terminal SPRY domain binds to the N-terminal CARDs of RIG-I, facilitating the delivery of a Lys 63-linked ubiquitin moiety to these CARDs and thereby significantly enhancing RIG-I downstream signaling activity. Which prote... | E3 ubiquitin/ISG15 ligase TRIM25 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05515","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RIG-I interacts with multiple proteins. One specific interaction involves a partner whose carboxy-terminal SPRY domain binds to the N-terminal CARDs ... | |
medium_divergent_branch_05517 | FNBP1 interacts with multiple genes. One of these interacting partners is supported by evidence stating: 'When overexpressed, CD95L co-precipitates with FBP17 and PACSIN.' Identify the disease associated with this specific interacting gene via a biomarker relationship. | cholangitis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05517","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FNBP1 interacts with multiple genes. One of these interacting partners is supported by evidence stating: 'When overexpressed, CD95L co-precipitates w... | |
medium_divergent_branch_05518 | The gene HTR1A is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating that Serotonin(1A) receptors belong to the family of G-protein-coupled receptors and are implicated in the generation and modulation of various cognitive, behavioral, ... | G protein-coupled amine receptor activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05518","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene HTR1A is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stat... | |
medium_divergent_branch_05519 | A mucus-secreting cell located within the submucosal glands of the tracheobronchial tree is a specific type of cell. Evidence indicates this cell is a subtype of a broader cell class found in exocrine tissues. Which anatomical structure is this broader cell class a part of? | exocrine gland | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05519","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"A mucus-secreting cell located within the submucosal glands of the tracheobronchial tree is a specific type of cell. Evidence indicates this cell is ... | |
medium_divergent_branch_05520 | EGLN1 interacts with multiple proteins. One interaction involves a tumor suppressor protein that acts as a molecular scaffold, simultaneously binding PHDs and VHL to assemble a PHD-scaffold-VHL complex, thereby facilitating the efficient degradation of HIF-1α. Which protein, encoded by the gene interacting with EGLN1 i... | LIM domain-containing protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05520","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EGLN1 interacts with multiple proteins. One interaction involves a tumor suppressor protein that acts as a molecular scaffold, simultaneously binding... | |
medium_divergent_branch_05521 | NLRP3 interacts with multiple proteins. One specific interaction involves a partner that constitutively interacts with NLRP3 to regulate susceptibility to HIV-1 infection. Which protein is encoded by the gene corresponding to this HIV-1 susceptibility-regulating partner? | P2Y purinoceptor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05521","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NLRP3 interacts with multiple proteins. One specific interaction involves a partner that constitutively interacts with NLRP3 to regulate susceptibili... | |
medium_divergent_branch_05522 | HMG20B interacts with multiple proteins. One interaction is supported by evidence stating: 'We have isolated a 2 MDa [protein]-containing complex and identified a structural DNA binding component, designated as [protein]-Associated Factor 35 (BRAF35).' Which protein, connected to HMG20B via this interaction, is encoded... | Breast cancer type 2 susceptibility protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05522","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HMG20B interacts with multiple proteins. One interaction is supported by evidence stating: 'We have isolated a 2 MDa [protein]-containing complex and... | |
medium_divergent_branch_05523 | PF4 is associated with multiple biological processes. One association is supported by evidence stating: 'These results indicate that PF4 and BTG are involved in negative regulation of normal and pathologic megakaryocytopoiesis and that their inhibition acts predominantly on the megakaryocytic lineage.' Which biological... | megakaryocyte differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05523","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PF4 is associated with multiple biological processes. One association is supported by evidence stating: 'These results indicate that PF4 and BTG are ... | |
medium_divergent_branch_05524 | KCNJ4 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we identify a new human ortholog of a Caenorhabditis elegans PDZ protein, hLin-7b, that interacts with the COOH-terminal tail of Kir 2.3 in renal epithelia.' Which cell type is the gene identified in this specific evidence enr... | plasmacytoid dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05524","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KCNJ4 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we identify a new human ortholog of a Caenorhabditis el... | |
medium_divergent_branch_05525 | BARD1 is involved in multiple biological processes. One line of evidence states: 'Our findings identify a novel apoptosis inhibitory function of BARD1.' Based on this evidence, which biological process is negatively regulated by the process in which BARD1 is involved? | apoptotic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05525","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BARD1 is involved in multiple biological processes. One line of evidence states: 'Our findings identify a novel apoptosis inhibitory function of BARD... | |
medium_divergent_branch_05526 | Macrophages are anatomically associated with multiple structures via the 'part of' relationship. One specific association is supported by the description: 'Stromal matrix surrounding blood vessels within the choroid plexus.' Which anatomical category is linked to this specific structure by the 'is a' relationship? | stroma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05526","source_qa_id":"medium_divergent_branch_07388","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"Macrophages are anatomically associated with multiple structures via the 'part of' relationship. ... | |
medium_divergent_branch_05527 | MICAL1 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating that immunostaining revealed MICAL localizes along with vimentin. Which cellular component, connected to the entity identified by this vimentin co-localization evidence, is linked t... | intermediate filament cytoskeleton | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05527","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MICAL1 is associated with multiple cellular components via the 'located in' relationship. One association is supported by evidence stating that immun... | |
medium_divergent_branch_05528 | The protein CUEDC2 is associated with multiple biological processes via the 'involved in' relationship. One of these associations is supported by evidence that CUEDC2 deficiency leads to excessive production of proinflammatory cytokines. Identify the biological process that is negatively regulated by the specific proce... | macrophage cytokine production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05528","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein CUEDC2 is associated with multiple biological processes via the 'involved in' relationship. One of these associations is supported by evi... | |
medium_divergent_branch_05530 | RACGAP1 interacts with multiple proteins. One specific interaction partner binds to RACGAP1 via its N-terminal domain (amino acids 1-428), and this binding is enhanced following EGF treatment. Which protein corresponds to this interaction partner? | SHC SH2 domain-binding protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05530","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RACGAP1 interacts with multiple proteins. One specific interaction partner binds to RACGAP1 via its N-terminal domain (amino acids 1-428), and this b... | |
medium_divergent_branch_05531 | FOXM1 interacts with multiple proteins. One specific interaction partner is described as co-regulating the transcription of CDCA3 together with FOXM1. Which protein product is encoded by the gene corresponding to this specific interaction partner? | Myb-related protein B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05531","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXM1 interacts with multiple proteins. One specific interaction partner is described as co-regulating the transcription of CDCA3 together with FOXM1... | |
medium_divergent_branch_05532 | CHEK2 interacts with multiple genes. One interaction is supported by evidence stating: 'In this study, we demonstrate that the ubiquitin E3 ligase [Gene A] (p53-induced protein with a RING (Really Interesting New Gene)-H2 domain) interacts with CHK2 and mediates its polyubiquitylation and proteasomal degradation.' Whic... | lung cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05532","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHEK2 interacts with multiple genes. One interaction is supported by evidence stating: 'In this study, we demonstrate that the ubiquitin E3 ligase [G... | |
medium_divergent_branch_05533 | GNG2 interacts with multiple proteins. One of these interaction partners is described as engaging symmetrically with five copies of Gβγ through its C-terminal domain in a pentameric form. Which protein corresponds to this description? | BTB/POZ domain-containing protein KCTD5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05533","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GNG2 interacts with multiple proteins. One of these interaction partners is described as engaging symmetrically with five copies of Gβγ through its C... | |
medium_divergent_branch_05535 | The erythropoietin receptor (EPOR) interacts with multiple proteins. One specific interaction is described by the following evidence: 'We have recently shown that the SH2 containing tyrosine phosphatase, Syp, binds directly to both the tyrosine phosphorylated form of the Epo receptor and to Grb2 after Epo stimulation o... | Tyrosine-protein phosphatase non-receptor type 11 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05535","source_qa_id":"medium_divergent_branch_06864","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The erythropoietin receptor (EPOR) interacts with multiple proteins. One specific interaction is ... | |
medium_divergent_branch_05536 | The gene TES interacts with multiple partners. One interaction is supported by evidence stating: 'Coimmunoprecipitations demonstrate that in vivo Tes is complexed with actin, a member of the enabled family, and vasodilator-stimulated phosphoprotein (VASP).' Which protein is encoded by the gene that interacts with TES i... | Protein enabled homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05536","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TES interacts with multiple partners. One interaction is supported by evidence stating: 'Coimmunoprecipitations demonstrate that in vivo Tes... | |
medium_divergent_branch_05537 | The biological process of extracellular matrix constituent secretion is enabled by multiple cell types. One such cell type is described as a fibroblast located in the adventitia of a blood vessel. This cell contributes to vascular homeostasis, remodeling, and inflammation by producing extracellular matrix components, c... | tunica adventitia of blood vessel | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05537","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The biological process of extracellular matrix constituent secretion is enabled by multiple cell types. One such cell type is described as a fibrobla... | |
medium_divergent_branch_05538 | NOTCH1 interacts with multiple genes. One of these interacting partners has been shown to interact with and cleave NOTCH1, resulting in the release of N1ICD. Which disease is associated with this specific interacting gene via a biomarker relationship? | tuberculosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05538","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NOTCH1 interacts with multiple genes. One of these interacting partners has been shown to interact with and cleave NOTCH1, resulting in the release o... | |
medium_divergent_branch_05540 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Human respirovirus 3 was found to upregulate a specific gene with a log2 fold change of 1.664 and an adjusted p-value of 0.04216. Which protein is encoded by this upregulated gene? | Phospholipase A and acyltransferase 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05540","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Human respirovirus 3 was found to upregulate a specific gene with a log2 fol... | |
medium_divergent_branch_05541 | BIRC2 interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'Similarly to XIAP, in vitro binding experiments indicated that c-IAP-1 and c-IAP-2 bound specifically to the terminal effector cell death proteases, caspases-3 and -7, but not to the proximal protease caspase-8, ca... | Caspase-3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05541","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BIRC2 interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'Similarly to XIAP, in vitro binding experim... | |
medium_divergent_branch_05542 | The gene MLLT4 interacts with multiple partners. One specific interaction involves a protein identified as the PDZ domain protein AF-6, which serves as an intracellular binding partner for the junctional adhesion molecule (JAM). Which disease is associated with this specific interacting partner (AF-6) via a biomarker r... | herpes zoster | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05542","source_qa_id":"medium_divergent_branch_02568","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene MLLT4 interacts with multiple partners. One specific interaction involves a protein iden... | |
medium_divergent_branch_05543 | FEN1 interacts with multiple proteins. One interaction is characterized by evidence stating that a PCNA-interacting box (PIP box)-containing peptide derived from hFen1 binds tightly to the interdomain connecting loop of hRad1, providing the molecular basis for the damage repair-specific activity of the 9-1-1 complex in... | thyroid gland papillary carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05543","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FEN1 interacts with multiple proteins. One interaction is characterized by evidence stating that a PCNA-interacting box (PIP box)-containing peptide ... |
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