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medium_divergent_branch_05544 | SFRP1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'While inhibition of endogenous SFRP1 increased the percentage of cell death in cultured human PDLFs, exogenous SFRP1 substantially reduced apoptosis in cultured human gingival fibroblasts, which do not ma... | fibroblast apoptotic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05544","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SFRP1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'While inhibition of endogenous SF... | |
medium_divergent_branch_05545 | RNF4 interacts with multiple genes. One interaction is supported by evidence stating: 'The activator of stromelysin 1 gene transcription, a transcription factor, interacts with the RING finger protein RNF4.' Which biological process is the gene involved in this specific interaction connected to via the 'involved in' re... | positive regulation of transcription by RNA polymerase II | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05545","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF4 interacts with multiple genes. One interaction is supported by evidence stating: 'The activator of stromelysin 1 gene transcription, a transcrip... | |
medium_divergent_branch_05546 | RASA3 interacts with multiple genes. One specific interaction is supported by evidence from GH4ZR7 cells, where co-immunoprecipitation of endogenous proteins revealed a complex between Galphai3 and the interacting partner, induced upon TRH/D2S receptor co-activation. Which disease is associated with this specific inter... | auriculocondylar syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05546","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RASA3 interacts with multiple genes. One specific interaction is supported by evidence from GH4ZR7 cells, where co-immunoprecipitation of endogenous ... | |
medium_divergent_branch_05548 | MCM5 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that human [protein encoded by the interacting gene] is capable of interacting with individual MCM proteins 2 through 7 when co-expressed in insect cells and can greatly increase the recovery of some recombinant MCM p... | Mini-chromosome maintenance complex-binding protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05548","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MCM5 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that human [protein encoded by the interacting... | |
medium_divergent_branch_05549 | GATA4 interacts with multiple proteins. One of these interaction partners is reported to physically associate with Nkx2.5 and GATA4 in vitro and in vivo, as determined by glutathione S-transferase pull-down and immunoprecipitation assays. Which protein is encoded by the gene corresponding to this interaction partner? | Protein Jumonji | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05549","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GATA4 interacts with multiple proteins. One of these interaction partners is reported to physically associate with Nkx2.5 and GATA4 in vitro and in v... | |
medium_divergent_branch_05550 | RB1 interacts with multiple proteins. One of these interaction partners is a known TRIM28 binding partner that protects phosphorylated RB1 from degradation by binding to methylated RB1 via its Tudor domain, a mechanism independent of its methyltransferase activity. Which protein is encoded by the gene corresponding to ... | Histone-lysine N-methyltransferase SETDB1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05550","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RB1 interacts with multiple proteins. One of these interaction partners is a known TRIM28 binding partner that protects phosphorylated RB1 from degra... | |
medium_divergent_branch_05551 | MECP2 is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence stating that the entity inhibits endothelial angiogenic characteristics partly through the epigenetic silencing of Sirt1. Which biological process is negatively regulated by the b... | angiogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05551","source_qa_id":"medium_divergent_branch_04607","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MECP2 is associated with multiple biological processes via the 'involved in' relationship. One sp... | |
medium_divergent_branch_05552 | The gene EDN2 is associated with multiple biological processes. One specific association is supported by evidence stating: 'As well as its chemotactic properties, ET-2 leads to activation of macrophages.' Identify the biological process described by this evidence, and then determine the parent biological process to whi... | myeloid leukocyte activation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05552","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene EDN2 is associated with multiple biological processes. One specific association is supported by evidence stating: 'As well as its chemotacti... | |
medium_divergent_branch_05553 | MYL2 interacts with multiple proteins. One interaction is characterized by evidence stating that the interacting partner phosphorylates MLC2 at Y118, an event that primes the binding of this partner to MLC2 and leads to subsequent partner-dependent phosphorylation of MLC2 at S15. Which protein is connected to MYL2 thro... | Rho-associated protein kinase 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05553","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MYL2 interacts with multiple proteins. One interaction is characterized by evidence stating that the interacting partner phosphorylates MLC2 at Y118,... | |
medium_divergent_branch_05554 | The gene ENAH interacts with multiple proteins. One interaction is supported by surface plasmon resonance analyses revealing that MENA, the interacting protein, and EVL mutually interacted. Which protein is encoded by the gene that interacts with ENAH in this specific context? | Vasodilator-stimulated phosphoprotein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05554","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ENAH interacts with multiple proteins. One interaction is supported by surface plasmon resonance analyses revealing that MENA, the interacti... | |
medium_divergent_branch_05555 | The corpus luteum is classified as a type of anatomy. One such classification is supported by evidence describing the entity as a transient endocrine gland that develops from postovulatory or atretic follicles, secretes progesterone, and is thought to be related to egg retention. Which broader anatomical structure is t... | female reproductive organ | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05555","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The corpus luteum is classified as a type of anatomy. One such classification is supported by evidence describing the entity as a transient endocrine... | |
medium_divergent_branch_05556 | The gene ITGB3 is known to interact with multiple partners. One specific interaction is supported by evidence stating: 'The alpha v beta 3 integrin is present on a variety of cell types and appears to act as a receptor for thrombospondin on endothelial and smooth muscle cells.' Based on this evidence, which protein is ... | Thrombospondin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05556","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ITGB3 is known to interact with multiple partners. One specific interaction is supported by evidence stating: 'The alpha v beta 3 integrin i... | |
medium_divergent_branch_05557 | ID2 interacts with multiple proteins. One interaction is supported by evidence stating: 'All three Ids bound with high affinity to E proteins, but a much broader range of interactions was observed between Ids and the class B factors.' Which protein, connected to ID2 via this specific interaction evidence, is encoded by... | Transcription factor E2-alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05557","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ID2 interacts with multiple proteins. One interaction is supported by evidence stating: 'All three Ids bound with high affinity to E proteins, but a ... | |
medium_divergent_branch_05558 | The KCNQ1 gene encodes the pore-forming alpha subunit of the cardiac I(Ks) channel, which forms heteromeric complexes with KCNE1, KCNE2, or KCNE3. This molecular function is associated with a specific biological process via a 'part of' relationship. Given that the evidence highlights the role of this channel in general... | membrane repolarization during cardiac muscle cell action potential | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05558","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The KCNQ1 gene encodes the pore-forming alpha subunit of the cardiac I(Ks) channel, which forms heteromeric complexes with KCNE1, KCNE2, or KCNE3. Th... | |
medium_divergent_branch_05559 | ZHX3 interacts with multiple genes. One interaction is supported by evidence stating: 'Mechanistically, coimmunoprecipitation (coIP) and mass spectrometry (MS) analysis indicated that ZHX3 was a target of tripartite motif 21, which mediates its ubiquitination, and subsequent degradation.' Which disease is associated wi... | vitiligo | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05559","source_qa_id":"medium_divergent_branch_01145","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ZHX3 interacts with multiple genes. One interaction is supported by evidence stating: 'Mechanisti... | |
medium_divergent_branch_05560 | FBN1 is associated with multiple biological processes. One association is supported by evidence that the soluble N-terminal half of fibrillin-1 (rFBN1-N) strongly inhibited osteoclastogenesis. Which biological process, connected to the process implicated by this evidence, is the target of a 'negatively regulates' relat... | osteoclast differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05560","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBN1 is associated with multiple biological processes. One association is supported by evidence that the soluble N-terminal half of fibrillin-1 (rFBN... | |
medium_divergent_branch_05561 | The gene CHRNA3 is known to physically interact with multiple partner genes. One specific interaction is supported by evidence stating: 'Besides, P2X2 co-immunoprecipitated α3β2 (but not α4β2) nAChR, both in HEK cells and rat hippocampal membranes indicating that this functional interaction is supported by a physical a... | nicotine dependence | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05561","source_qa_id":"medium_divergent_branch_00009","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene CHRNA3 is known to physically interact with multiple partner genes. One specific interac... | |
medium_divergent_branch_05562 | NCOA4 interacts with multiple proteins. One specific interaction is characterized by the partner protein directly binding to and ubiquitinating NCOA4 using K48-linked chains. Which protein corresponds to this specific interaction partner? | E3 ubiquitin-protein ligase TRIM7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05562","source_qa_id":"medium_divergent_branch_02617","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"NCOA4 interacts with multiple proteins. One specific interaction is characterized by the partner ... | |
medium_divergent_branch_05563 | GATA2 interacts with multiple proteins. One specific interaction is characterized by the finding that substituting threonine 176 with alanine in GATA2 inhibits its binding to the partner protein, thereby suppressing the ubiquitylation and degradation of GATA2 by this partner. Which protein is the partner in this specif... | F-box/WD repeat-containing protein 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05563","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GATA2 interacts with multiple proteins. One specific interaction is characterized by the finding that substituting threonine 176 with alanine in GATA... | |
medium_divergent_branch_05564 | BMAL1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we show that the ubiquitin-conjugating enzyme [protein] interacts with BMAL1 and promotes its ubiquitination and degradation.' Which protein, encoded by the gene connected to BMAL1 via this specific interaction, is ... | (E3-independent) E2 ubiquitin-conjugating enzyme | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05564","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BMAL1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we show that the ubiquitin-conjugating enzym... | |
medium_divergent_branch_05565 | The gene NBN is known to interact with multiple proteins. One specific interaction is supported by experimental evidence stating: 'Experiments with purified proteins indicated that a specific DNA helicase interacts with the MRN complex through both MRE11 and NBS1.' Based on this specific evidence, which protein product... | ATP-dependent DNA helicase Q5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05565","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NBN is known to interact with multiple proteins. One specific interaction is supported by experimental evidence stating: 'Experiments with p... | |
medium_divergent_branch_05566 | The gene RAB7A is reported to interact with multiple proteins. One specific interaction is supported by evidence stating: 'In response to SDF-1, a specific protein also bound transiently to the small GTPase Rab5 at 5 min and to Rab7 at 30 min.' Based on this evidence, which protein is encoded by the gene that interacts... | Protein MTSS 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05566","source_qa_id":"medium_divergent_branch_02881","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene RAB7A is reported to interact with multiple proteins. One specific interaction is suppor... | |
medium_divergent_branch_05567 | ZDHHC5 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here, we report that the protein interacts with and is palmitoylated by the palmitoyltransferase ZDHHC5.' What is the name of the protein encoded by the gene that is the subject of this report? | Protocadherin-7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05567","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZDHHC5 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here, we report that the protein interacts with ... | |
medium_divergent_branch_05568 | CCND1 interacts with multiple proteins. One of these interaction partners physically binds to the N-terminal domain of cyclin D1 and removes K48-linked (but not K63-linked) polyubiquitination chains, thereby stabilizing and increasing cyclin D1 levels. Which protein corresponds to this interaction partner? | Ubiquitin carboxyl-terminal hydrolase 13 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05568","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CCND1 interacts with multiple proteins. One of these interaction partners physically binds to the N-terminal domain of cyclin D1 and removes K48-link... | |
medium_divergent_branch_05569 | HSPA9 is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence stating that knockdown of HSPA9 in human cells significantly delayed the maturation of erythroid precursors. Which biological process, linked to this specific process by the 'part... | erythrocyte homeostasis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05569","source_qa_id":"medium_divergent_branch_03749","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"HSPA9 is associated with multiple biological processes via the 'involved in' relationship. One sp... | |
medium_divergent_branch_05570 | FBXO7 interacts with multiple proteins. One of these interactions is supported by evidence stating that a Co-immunoprecipitation assay showed the protein encoded by BIRC2 can interact with this partner in human cells. Which protein is encoded by the gene corresponding to this interaction partner? | Baculoviral IAP repeat-containing protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05570","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXO7 interacts with multiple proteins. One of these interactions is supported by evidence stating that a Co-immunoprecipitation assay showed the pro... | |
medium_divergent_branch_05571 | PRKACA interacts with multiple proteins. One interaction is supported by evidence stating: 'The PKI alpha isoform displayed increased IC50 values for C alpha Y235S (71-fold), C alpha F239S (150-fold), and C alpha Y235S/F239S (1800-fold).' Which protein, connected to PRKACA via an interaction, is encoded by the gene ass... | cAMP-dependent protein kinase inhibitor alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05571","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKACA interacts with multiple proteins. One interaction is supported by evidence stating: 'The PKI alpha isoform displayed increased IC50 values for... | |
medium_divergent_branch_05572 | DUSP1 interacts with multiple proteins. One specific interaction is characterized by the following evidence: 'Furthermore, we found that the protein could interact with the phosphatase DUSP1 to negatively regulate the activation of JNK, while the protein knockdown promoted the proteasomal degradation of DUSP1.' What is... | Ubiquitin carboxyl-terminal hydrolase 33 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05572","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DUSP1 interacts with multiple proteins. One specific interaction is characterized by the following evidence: 'Furthermore, we found that the protein ... | |
medium_divergent_branch_05573 | CUL5 interacts with multiple proteins. One interaction is supported by evidence stating: 'Furthermore, we confirmed that the protein is involved in the formation of a novel E3 ligase through interaction with CUL5-ELOB/C-RNF7 and the three deleterious variants affected the binding amount of the protein and CUL5 to a cer... | Tubby-related protein 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05573","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CUL5 interacts with multiple proteins. One interaction is supported by evidence stating: 'Furthermore, we confirmed that the protein is involved in t... | |
medium_divergent_branch_05574 | MYH9 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we demonstrate an interaction between a neural precursor cell-expressed, developmentally down-regulated protein and the cytoskeletal proteins vimentin and non-muscle myosin IIA (NMIIA), based on co-immunoprecipitation and mas... | Enhancer of filamentation 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05574","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MYH9 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we demonstrate an interaction between a neural precurs... | |
medium_divergent_branch_05575 | BCL2 interacts with multiple proteins. One interaction partner is described by the following evidence: 'The product of harakiri physically interacts with the death-repressor proteins Bcl-2 and Bcl-X(L), but not with death-promoting homologs, Bax or Bak.' Which protein is encoded by the gene corresponding to this intera... | Activator of apoptosis harakiri | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05575","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BCL2 interacts with multiple proteins. One interaction partner is described by the following evidence: 'The product of harakiri physically interacts ... | |
medium_divergent_branch_05576 | SSTR3 is associated with multiple molecular functions via the 'enables' relationship. One such function is supported by evidence stating: 'It is concluded that, in an appropriate cellular environment, all four receptor subtypes can functionally couple to the inhibition of adenylyl cyclase.' Which molecular function, co... | neuropeptide receptor activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05576","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SSTR3 is associated with multiple molecular functions via the 'enables' relationship. One such function is supported by evidence stating: 'It is conc... | |
medium_divergent_branch_05577 | CD80 interacts with multiple proteins. One interaction is supported by evidence stating: 'We have identified, by site-directed mutagenesis of soluble forms of CD80 and CD86, residues in both the IgV and IgC domains that are important for CTLA4Ig and CD28Ig binding.' Which protein, connected to CD80 via this binding int... | T-cell-specific surface glycoprotein CD28 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05577","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD80 interacts with multiple proteins. One interaction is supported by evidence stating: 'We have identified, by site-directed mutagenesis of soluble... | |
medium_divergent_branch_05578 | mmu-miR-181 regulates multiple cell types. One specific regulatory connection is supported by evidence stating: 'Here, we report that miR-181 is a nonredundant determinant of cellular metabolism and is essential for supporting the biosynthetic demands of early NKT cell development.' Which cell type, connected to mmu-mi... | mature NK T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05578","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"mmu-miR-181 regulates multiple cell types. One specific regulatory connection is supported by evidence stating: 'Here, we report that miR-181 is a no... | |
medium_divergent_branch_05579 | PIK3R1 interacts with multiple genes. One of these interaction partners functions as an adaptor protein that binds to the regulatory p85 subunit of phosphatidylinositol 3-kinase, phospholipase Cgamma, and SOCS family members (SOCS2, SOCS6, and SOCS7), thereby modulating LR signaling. Which biological process is this sp... | signal transduction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05579","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PIK3R1 interacts with multiple genes. One of these interaction partners functions as an adaptor protein that binds to the regulatory p85 subunit of p... | |
medium_divergent_branch_05580 | ERLIN2 interacts with multiple genes. One of these interaction partners has been shown to enhance the effect of ERLIN2 on Cyclin B1 stability. Which cellular component is this specific interaction partner located in? | voltage-gated potassium channel complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05580","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERLIN2 interacts with multiple genes. One of these interaction partners has been shown to enhance the effect of ERLIN2 on Cyclin B1 stability. Which ... | |
medium_divergent_branch_05581 | The biological process 'regulation of meiotic nuclear division' is defined as any process that modulates the frequency, rate, or extent of meiotic nuclear division, which is the process in which the nucleus of a diploid cell divides twice to form four haploid cells, one or more of which usually function as gametes. Bas... | regulation of organelle organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05581","source_qa_id":"medium_divergent_branch_03421","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'regulation of meiotic nuclear division' is defined as any process that mo... | |
medium_divergent_branch_05582 | RSAD2 (Viperin) interacts with multiple genes. One specific interaction involves a partner that is recruited by acetylated Viperin to stimulate K6-linked polyubiquitination at Lys206, leading to Viperin degradation. Which gene is this interacting partner? | IP6K1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05582","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RSAD2 (Viperin) interacts with multiple genes. One specific interaction involves a partner that is recruited by acetylated Viperin to stimulate K6-li... | |
medium_divergent_branch_05583 | FKBP8 interacts with multiple proteins. One interaction is supported by evidence stating: 'Binding assays in vitro also revealed that FKBP38 directly interacts with the S4 subunit of the 19S proteasome.' Which protein, connected to FKBP8 via an interaction, is encoded by the gene corresponding to this specific interact... | 26S proteasome regulatory subunit 6B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05583","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FKBP8 interacts with multiple proteins. One interaction is supported by evidence stating: 'Binding assays in vitro also revealed that FKBP38 directly... | |
medium_divergent_branch_05584 | EIF4G1 is involved in multiple biological processes. One of these processes is characterized by evidence that EIF4G1 associates with eIF1, and both proteins promote scanning and AUG selection. Which biological process is a parent of this specific process in the ontology hierarchy? | metabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05584","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF4G1 is involved in multiple biological processes. One of these processes is characterized by evidence that EIF4G1 associates with eIF1, and both p... | |
medium_divergent_branch_05585 | The gene TNFRSF4 is enriched in multiple cell types. One specific cell type shows a mean expression of 30.45 TPM, a z-score of 2.14, and a fold enrichment of 8.83. Which cell type is this, and what is its immediate parent category in the cell type hierarchy (i.e., what is it a subtype of)? | mature T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05585","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TNFRSF4 is enriched in multiple cell types. One specific cell type shows a mean expression of 30.45 TPM, a z-score of 2.14, and a fold enric... | |
medium_divergent_branch_05586 | FBXO6 interacts with multiple proteins. One interaction partner is characterized by the finding that, in vivo, the majority of Fbs1 exists as Fbs1-heterodimers or Fbs1 monomers, rather than as part of the SCF(Fbs1) complex. Which disease is associated with this specific interaction partner? | kidney cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05586","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXO6 interacts with multiple proteins. One interaction partner is characterized by the finding that, in vivo, the majority of Fbs1 exists as Fbs1-he... | |
medium_divergent_branch_05587 | XPO1 interacts with multiple genes. Evidence for one of these interactions indicates that the protein product binds directly to Crm1, forming a complex with enhanced affinity for both Ran:GTP and cargo. Which protein is encoded by the gene connected to XPO1 through this specific interaction? | Ran-binding protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05587","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"XPO1 interacts with multiple genes. Evidence for one of these interactions indicates that the protein product binds directly to Crm1, forming a compl... | |
medium_divergent_branch_05588 | FANCM interacts with multiple proteins. One interaction partner is part of the BLM-TopoIII-RMI1/2 (BRCA1-A complex) and is described in evidence as interacting with MM2 and RM1. Which disease is associated with genomic alterations in this specific interaction partner? | microcephaly | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05588","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FANCM interacts with multiple proteins. One interaction partner is part of the BLM-TopoIII-RMI1/2 (BRCA1-A complex) and is described in evidence as i... | |
medium_divergent_branch_05589 | SMAD6 interacts with multiple proteins. One interaction is supported by evidence stating: 'We carried out docking of the WW2 domain of this protein with the PPXY motifs of Smad1, Smad5, and Smad6 and identified the key amino acid residues involved in interaction.' Which protein, connected to SMAD6 through this binding ... | E3 ubiquitin-protein ligase SMURF1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05589","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMAD6 interacts with multiple proteins. One interaction is supported by evidence stating: 'We carried out docking of the WW2 domain of this protein w... | |
medium_divergent_branch_05590 | ADAR is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating that N-terminally truncated forms of ADAR are exclusively nuclear and accumulate in this specific sub-nuclear structure. Which cellular component is connected to this sub-nuc... | nuclear lumen | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05590","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ADAR is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating tha... | |
medium_divergent_branch_05591 | KLF2 interacts with multiple proteins. One of these interaction partners is an E3 ubiquitin ligase identified in a yeast-two-hybrid screen, which binds specifically to the LKLF inhibitory domain but not to other transcription factors. Which protein is encoded by the gene corresponding to this specific interaction partn... | NEDD4-like E3 ubiquitin-protein ligase WWP1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05591","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KLF2 interacts with multiple proteins. One of these interaction partners is an E3 ubiquitin ligase identified in a yeast-two-hybrid screen, which bin... | |
medium_divergent_branch_05592 | MAPK3 interacts with multiple proteins. One interaction involves a protein that blocks ERK-dependent transcription and proliferation by binding ERKs and preventing their nuclear localization. Which protein product is encoded by the gene corresponding to this interacting partner? | Astrocytic phosphoprotein PEA-15 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05592","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAPK3 interacts with multiple proteins. One interaction involves a protein that blocks ERK-dependent transcription and proliferation by binding ERKs ... | |
medium_divergent_branch_05594 | ANAPC1 interacts with multiple proteins. One interaction is characterized by the observation that while mutants in both motifs assemble the Mitotic Checkpoint Complex (MCC) normally, the integrity of the IR motif is particularly important for stable binding to the APC/C. Which protein, encoded by the gene involved in t... | Cell division cycle protein 20 homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05594","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ANAPC1 interacts with multiple proteins. One interaction is characterized by the observation that while mutants in both motifs assemble the Mitotic C... | |
medium_divergent_branch_05595 | GABBR1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Our data indicate that Kir 3 channels and Gbetagamma subunits can interact with the GABA-B(1) subunits independently of the GABA-B(2) subunit or Kir 3.4 which are ultimately responsible for their targetting to the cell surface.'... | G protein-activated inward rectifier potassium channel 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05595","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GABBR1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Our data indicate that Kir 3 channels and Gbetagamma subu... | |
medium_divergent_branch_05596 | SMARCAD1 interacts with multiple proteins. One interaction partner was identified as the RNA polymerase III general transcription factor TFIIIC in mouse and human models using endogenous co-immunoprecipitations. Which protein, encoded by a gene interacting with SMARCAD1, corresponds to this TFIIIC component? | General transcription factor 3C polypeptide 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05596","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMARCAD1 interacts with multiple proteins. One interaction partner was identified as the RNA polymerase III general transcription factor TFIIIC in mo... | |
medium_divergent_branch_05598 | TAP1 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating that HLA-F associates with components of the conventional class I assembly pathway, including calreticulin and TAP. Which molecular function, connected to this specific TAP1 fun... | MHC protein binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05598","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TAP1 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating that H... | |
medium_divergent_branch_05599 | The protein TESC is associated with multiple biological processes. One specific association is supported by evidence stating: 'We show here that the process of megakaryocytic differentiation requires the presence of the recently discovered protein tescalcin.' Based on this evidence, which biological process is connecte... | megakaryocyte differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05599","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein TESC is associated with multiple biological processes. One specific association is supported by evidence stating: 'We show here that the ... | |
medium_divergent_branch_05600 | The protein HYAL2 is associated with multiple cellular components via 'located in' relationships. One specific association is supported by evidence stating: 'Expression of this cDNA yielded a polypeptide termed HYAL2, which is located in lysosomes.' Based on this evidence, identify the cellular component linked to HYAL... | lytic vacuole | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05600","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein HYAL2 is associated with multiple cellular components via 'located in' relationships. One specific association is supported by evidence s... | |
medium_divergent_branch_05601 | PLEKHA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We demonstrate that immunoprecipitation of endogenously expressed TAPP1 from 293-cell lysates results in the co-immunoprecipitation of endogenous [Protein X], indicating that these proteins are likely to interact with each othe... | Multiple PDZ domain protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05601","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PLEKHA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We demonstrate that immunoprecipitation of endogenously ... | |
medium_divergent_branch_05603 | CFLAR interacts with multiple proteins. One of these interaction partners is reported to interact with Casper, caspase-8, caspase-3, and TRAF1 through distinct domains. Which protein, connected to CFLAR via a binding interaction, is encoded by the gene in question? | TNF receptor-associated factor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05603","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CFLAR interacts with multiple proteins. One of these interaction partners is reported to interact with Casper, caspase-8, caspase-3, and TRAF1 throug... | |
medium_divergent_branch_05604 | CHMP5 interacts with multiple proteins. One of these interaction partners is supported by evidence stating: 'The primary interaction was confirmed by coimmunoprecipitation and/or bioluminescence resonance energy transfer (BRET) experiments for 11 of these proteins (ANKHD1, the hidden candidate, SDCCAG3, TRIM41, LDOC1, ... | Nucleotide-binding oligomerization domain-containing protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05604","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHMP5 interacts with multiple proteins. One of these interaction partners is supported by evidence stating: 'The primary interaction was confirmed by... | |
medium_divergent_branch_05605 | IKBKB interacts with multiple genes. One interaction is supported by evidence stating that a MAP3K family member interacts with and stimulates the activities of both IKKalpha and IKKbeta in transfected HeLa and COS-1 cells and directly phosphorylates the IKKs in vitro. Which cellular component is the gene identified by... | tight junction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05605","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IKBKB interacts with multiple genes. One interaction is supported by evidence stating that a MAP3K family member interacts with and stimulates the ac... | |
medium_divergent_branch_05606 | ADORA2A interacts with multiple proteins. One interaction partner was identified as a neuronal calcium-binding protein that binds to the C-terminal domain of the adenosine A(2A) receptor, as determined by a yeast two-hybrid screen. Which protein is encoded by the gene corresponding to this specific interaction partner? | N-terminal EF-hand calcium-binding protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05606","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ADORA2A interacts with multiple proteins. One interaction partner was identified as a neuronal calcium-binding protein that binds to the C-terminal d... | |
medium_divergent_branch_05607 | NFE2L2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Immunoprecipitation-immunoblotting, chromatin immunoprecipitation, and GST pull-down assays revealed that a corepressor recruited to steroid-GR complex for histone deacetylation, bound to TAD domain of C/EBPbeta and Neh4/5 domai... | Nuclear receptor corepressor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05607","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NFE2L2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Immunoprecipitation-immunoblotting, chromatin immunopreci... | |
medium_divergent_branch_05608 | AMBRA1 interacts with multiple proteins. One interaction is characterized by the finding that the partner protein associates with AMBRA1 to function as an E3 ligase, ubiquitinating AMBRA1 via K48 linkage. Which protein, connected to AMBRA1 through this specific interaction, is encoded by the gene in question? | E3 ubiquitin-protein ligase RING2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05608","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AMBRA1 interacts with multiple proteins. One interaction is characterized by the finding that the partner protein associates with AMBRA1 to function ... | |
medium_divergent_branch_05609 | GNB2 interacts with multiple proteins. One interaction is supported by evidence stating: 'The data show that PhLP1 plays a vital role in the assembly of Ggamma2 with all four Gbeta1-4 subunits and in the assembly of Gbeta2 with all twelve Ggamma subunits, without affecting the specificity of the Gbetagamma interactions... | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05609","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GNB2 interacts with multiple proteins. One interaction is supported by evidence stating: 'The data show that PhLP1 plays a vital role in the assembly... | |
medium_divergent_branch_05610 | The gene MYLIP interacts with multiple partners. One specific interaction is supported by evidence stating that the FERM domain interacts with this partner and co-localizes with the receptor at the plasma membrane in living cells. Which cell type is this interaction partner enriched in? | basophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05610","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene MYLIP interacts with multiple partners. One specific interaction is supported by evidence stating that the FERM domain interacts with this p... | |
medium_divergent_branch_05611 | RPS6KA1 interacts with multiple proteins. One specific interaction is characterized by the following evidence: In endothelial cells exposed to disturbed flow, p90 ribosomal S6 kinase (p90RSK) binds to the interacting partner, leading to phosphorylation of that partner at serine 741 (S741) and deSUMOylation at lysine 93... | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05611","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RPS6KA1 interacts with multiple proteins. One specific interaction is characterized by the following evidence: In endothelial cells exposed to distur... | |
medium_divergent_branch_05612 | HMGA1 interacts with multiple genes. One of these interaction partners is described as physically interacting with the conserved POU domains of both Oct-1 and Oct-2A. Which biological process is this specific interaction partner involved in? | humoral immune response | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05612","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HMGA1 interacts with multiple genes. One of these interaction partners is described as physically interacting with the conserved POU domains of both ... | |
medium_divergent_branch_05615 | SMURF1 is associated with multiple cellular components via the 'located in' relationship. One piece of evidence states: 'However, unlike Smurf1(WT), Smurf1(deltaC2) did not move to the [cellular component] and failed to recruit Smad7 to the cell surface TbetaR-II.TbetaR-I complex.' Based on this evidence, which cellula... | membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05615","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMURF1 is associated with multiple cellular components via the 'located in' relationship. One piece of evidence states: 'However, unlike Smurf1(WT), ... | |
medium_divergent_branch_05616 | DROSHA interacts with multiple proteins. One interaction is supported by evidence stating: 'Through the characterization of the interactomes of apurinic/apyrimidinic endonuclease 1 with RNA and other proteins, we demonstrate here a role for apurinic/apyrimidinic endonuclease 1 in pri-miRNA processing and stability via ... | DNA repair nuclease/redox regulator APEX1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05616","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DROSHA interacts with multiple proteins. One interaction is supported by evidence stating: 'Through the characterization of the interactomes of apuri... | |
medium_divergent_branch_05617 | The buccopharyngeal membrane is a component of multiple anatomical structures. One such structure is described as the site where the thin bilaminar membrane, derived from the prechordal plate and formed by the apposition of stomodeal ectoderm with foregut endoderm, lies at the caudal limit of the stomodeum after the em... | anatomical junction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05617","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The buccopharyngeal membrane is a component of multiple anatomical structures. One such structure is described as the site where the thin bilaminar m... | |
medium_divergent_branch_05618 | AGO2 interacts with multiple genes. One interaction is supported by evidence stating: 'We show that a nuclear transport factor interacts with Ago proteins and localizes to cytoplasmic processing bodies (P bodies), structures involved in RNA metabolism.' Which disease is associated with the gene identified by this evide... | VISS syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05618","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AGO2 interacts with multiple genes. One interaction is supported by evidence stating: 'We show that a nuclear transport factor interacts with Ago pro... | |
medium_divergent_branch_05619 | FBXL4 interacts with multiple proteins. One specific interaction involves the SCF-FBXL4 complex ubiquitinating a target protein along with NIX to target them for degradation. Which protein is this target that is co-ubiquitinated with NIX? | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05619","source_qa_id":"medium_divergent_branch_00807","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"FBXL4 interacts with multiple proteins. One specific interaction involves the SCF-FBXL4 complex u... | |
medium_divergent_branch_05620 | GCG interacts with multiple genes via binding. One specific interaction is supported by evidence stating: 'The purified N-terminal fragment (hereafter referred to as NT) of the glucagon-like peptide-1 receptor produced in either insect (Sf9) or mammalian (COS-7) cells was shown to bind GLP-1.' Which disease is associat... | hyperinsulinemic hypoglycemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05620","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GCG interacts with multiple genes via binding. One specific interaction is supported by evidence stating: 'The purified N-terminal fragment (hereafte... | |
medium_divergent_branch_05621 | CDH5 interacts with multiple proteins. One interaction is supported by evidence stating: 'These junctions are formed by the homotypic interaction of a transmembrane protein, vascular endothelial cadherin (VE-cadherin), which is complexed to an intracellular protein network including alpha-, beta-, and gamma-catenin.' W... | Catenin alpha-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05621","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDH5 interacts with multiple proteins. One interaction is supported by evidence stating: 'These junctions are formed by the homotypic interaction of ... | |
medium_divergent_branch_05622 | RFFL interacts with multiple genes. Evidence from a BioID interactome analysis indicates that RFFL interacts with the Rab11 effectors EHD1, a specific partner, and class I Rab11-FIPs. Which cellular component is this specific partner located in? | mitochondrial outer membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05622","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RFFL interacts with multiple genes. Evidence from a BioID interactome analysis indicates that RFFL interacts with the Rab11 effectors EHD1, a specifi... | |
medium_divergent_branch_05623 | SOX9 is involved in multiple biological processes. One specific connection is supported by evidence stating: 'We demonstrate how three human sex-determining factors are likely to function during gonadal development around SOX9 as a hub gene, with different genetic causes of 46,XY DSD due a common failure to upregulate ... | male gonad development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05623","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SOX9 is involved in multiple biological processes. One specific connection is supported by evidence stating: 'We demonstrate how three human sex-dete... | |
medium_divergent_branch_05624 | PTPN12 interacts with multiple genes. One interaction is supported by evidence stating: 'We carried out yeast two-hybrid screening to identify cellular factors that form a complex with a specific protein using its LIM domains as a bait, and we identified a cytoplasmic tyrosine phosphatase (PTP-PEST) as one of the partn... | Transforming growth factor beta-1-induced transcript 1 protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05624","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTPN12 interacts with multiple genes. One interaction is supported by evidence stating: 'We carried out yeast two-hybrid screening to identify cellul... | |
medium_divergent_branch_05625 | DNM1L interacts with multiple proteins. One of these interaction partners has been shown to interact with DLP1, and this specific interaction is enhanced by Parkinson's disease-associated mutations, likely leading to increased mitochondrial DLP1 levels. Which protein, encoded by the gene corresponding to this interacti... | Leucine-rich repeat serine/threonine-protein kinase 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05625","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DNM1L interacts with multiple proteins. One of these interaction partners has been shown to interact with DLP1, and this specific interaction is enha... | |
medium_divergent_branch_05626 | SMARCA4 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found using pull-down experiments and co-immunoprecipitation assays that both proteins associate with this partner.' Which protein, connected to SMARCA4 via this specific interaction evidence, is the gene that encodes the pr... | Signal transducer and activator of transcription 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05626","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMARCA4 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found using pull-down experiments and co-immunoprecip... | |
medium_divergent_branch_05627 | MYOD1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We show that the muscle determination factor MyoD and the SWI/SNF subunit [protein encoded by SMARCD3] interact on the regulatory elements of MyoD-target genes in myoblasts, prior to activation of transcription.' Which protein, e... | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05627","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MYOD1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We show that the muscle determination factor MyoD and the ... | |
medium_divergent_branch_05628 | GMEB1 interacts with multiple proteins. One of these interactions was confirmed in mammalian cell lines using immunoprecipitation assays. Which protein, connected to GMEB1 via this specific interaction evidence, is encoded by the gene in question? | TNF receptor-associated factor 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05628","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GMEB1 interacts with multiple proteins. One of these interactions was confirmed in mammalian cell lines using immunoprecipitation assays. Which prote... | |
medium_divergent_branch_05629 | PSMD3 interacts with multiple proteins. One of these interaction partners is described as interacting with both HBx and the proteasome 19S lid subunit RPN3 via its C-terminal acidic tail. Which protein is encoded by the gene corresponding to this specific interaction partner? | Testis-specific Y-encoded-like protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05629","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PSMD3 interacts with multiple proteins. One of these interaction partners is described as interacting with both HBx and the proteasome 19S lid subuni... | |
medium_divergent_branch_05630 | Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.182 and an adjusted p-value of 0.0469. Which protein does that selected gene encode? | Midnolin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05630","source_qa_id":"medium_divergent_branch_04943","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fo... | |
medium_divergent_branch_05631 | MIR448 is associated with multiple biological processes. One association is supported by evidence that overexpression of miR-448 promoted vascular smooth muscle cell (VSMC) migration. Which biological process, connected to the process supported by this evidence via a 'positively regulates' relationship, is the target o... | vascular associated smooth muscle cell migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05631","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR448 is associated with multiple biological processes. One association is supported by evidence that overexpression of miR-448 promoted vascular sm... | |
medium_divergent_branch_05632 | ARRB2 interacts with multiple genes. Evidence for one specific interaction states: 'Truncation analyses indicate that two sites in beta-arrestin 2 are involved in mediating its interaction with PDE4D5, one associated with its extreme amino-terminal region and the other located within the carboxyl-terminal domain of the... | glioma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05632","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARRB2 interacts with multiple genes. Evidence for one specific interaction states: 'Truncation analyses indicate that two sites in beta-arrestin 2 ar... | |
medium_divergent_branch_05634 | In renal epithelial cells, Human polyomavirus 2 infection is associated with the downregulation of a specific gene. Evidence for this interaction reports a log2 fold change of -1.309 and an adjusted p-value of 0.0003696. Which protein is encoded by this downregulated gene? | Mast cell carboxypeptidase A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05634","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"In renal epithelial cells, Human polyomavirus 2 infection is associated with the downregulation of a specific gene. Evidence for this interaction rep... | |
medium_divergent_branch_05635 | EFEMP2 interacts with multiple genes. One of these interactions is supported by evidence describing a specific interaction between MBP1 and a tumor suppressor protein, demonstrated via two-hybrid analysis in yeast and co-immunoprecipitation in mammalian cells. Which protein is encoded by the gene that interacts with EF... | Cellular tumor antigen p53 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05635","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EFEMP2 interacts with multiple genes. One of these interactions is supported by evidence describing a specific interaction between MBP1 and a tumor s... | |
medium_divergent_branch_05636 | The gene P4HB interacts with multiple other genes. One of these interacting partners has been shown to bind directly to PDIA1, with dissociation constants quantified via microscale thermophoresis and fluorescence correlation spectroscopy. Which protein is encoded by the gene that interacts with P4HB and binds to PDIA1? | von Willebrand factor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05636","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene P4HB interacts with multiple other genes. One of these interacting partners has been shown to bind directly to PDIA1, with dissociation cons... | |
medium_divergent_branch_05637 | NOTCH3 interacts with multiple proteins. One specific interaction is supported by evidence stating that Co-immunoprecipitation experiments showed the interacting partner bound to N3-ICD but not to intracellular domains from other Notch receptors. Which protein corresponds to this specific interaction partner? | NEDD4-like E3 ubiquitin-protein ligase WWP2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05637","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NOTCH3 interacts with multiple proteins. One specific interaction is supported by evidence stating that Co-immunoprecipitation experiments showed the... | |
medium_divergent_branch_05638 | RNF125 interacts with multiple proteins. One specific interaction is characterized by RNF125 acting as an E3 ubiquitin ligase that catalyzes the ubiquitination of its binding partner. Which protein, encoded by the gene connected to RNF125 via this specific interaction, is the substrate of this ubiquitination event? | Tripartite motif-containing protein 14 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05638","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF125 interacts with multiple proteins. One specific interaction is characterized by RNF125 acting as an E3 ubiquitin ligase that catalyzes the ubiq... | |
medium_divergent_branch_05639 | TLX1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We observed that the protein HOX11 interacted with protein serine-threonine phosphatase 2A catalytic subunit (PP2AC), as well as protein phosphatase 1 (PP1C) in mammalian cells.' Note that TLX1 is also known as HOX11. Which protei... | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05639","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TLX1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We observed that the protein HOX11 interacted with protein ... | |
medium_divergent_branch_05640 | The protein ACTC1 is associated with multiple cellular components via the 'located in' relationship. One association is supported by the evidence: 'We show that alpha-cardiac actin is the predominant sarcomeric isoform in human donor hearts and in early foetal skeletal muscle development.' Which cellular component is c... | myofibril | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05640","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein ACTC1 is associated with multiple cellular components via the 'located in' relationship. One association is supported by the evidence: 'W... | |
medium_divergent_branch_05641 | ATR interacts with multiple genes. One of these interacting partners is recruited to DNA double-strand breaks (DSB) via its interaction with the upstream DNA damage checkpoint kinase ATR. Which disease is associated with this specific gene through a biomarker relationship? | Burkitt lymphoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05641","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATR interacts with multiple genes. One of these interacting partners is recruited to DNA double-strand breaks (DSB) via its interaction with the upst... | |
medium_divergent_branch_05642 | USP27X interacts with multiple proteins. One of these interaction partners is stabilized by USP27X through a mechanism involving glycogen synthase kinase 3 beta (GSK3β), which directly binds to and phosphorylates USP27X, thereby enhancing the interaction between USP27X and this partner. Which protein is this interactio... | Chromobox protein homolog 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05642","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP27X interacts with multiple proteins. One of these interaction partners is stabilized by USP27X through a mechanism involving glycogen synthase ki... | |
medium_divergent_branch_05644 | SASS6 interacts with multiple proteins. One interaction is supported by evidence stating: 'In contrast, during HsSAS-6 overexpression, the protein strongly associated with HsSAS-6 at the centriole.' Which protein corresponds to this description, and what is the name of the protein product encoded by the gene for this p... | F-box/WD repeat-containing protein 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05644","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SASS6 interacts with multiple proteins. One interaction is supported by evidence stating: 'In contrast, during HsSAS-6 overexpression, the protein st... | |
medium_divergent_branch_05646 | GSK3B is known to interact with multiple proteins. One specific interaction involves a partner that suppresses GSK-3β Ser9 phosphorylation in vitro and in HEK-293FT cells. Which protein product is encoded by the gene corresponding to this specific interacting partner? | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05646","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GSK3B is known to interact with multiple proteins. One specific interaction involves a partner that suppresses GSK-3β Ser9 phosphorylation in vitro a... | |
medium_divergent_branch_05647 | TAF1 interacts with multiple proteins. One interaction is supported by coimmunoprecipitation and protein-protein interaction assays confirming that the partner binds to the protein encoded by the gene UBTF. Which protein is encoded by the gene corresponding to this interacting partner? | Nucleolar transcription factor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05647","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TAF1 interacts with multiple proteins. One interaction is supported by coimmunoprecipitation and protein-protein interaction assays confirming that t... | |
medium_divergent_branch_05648 | COL1A1 interacts with multiple genes. One of these interacting partners is supported by evidence stating: 'All radiolabeled PDGF isoforms specifically interacted with type I, II, III, IV, V, and VI collagens (preferential binding to types III, I, VI, and IV) and their constituent chains, either when immobilized on poly... | glomerulonephritis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05648","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"COL1A1 interacts with multiple genes. One of these interacting partners is supported by evidence stating: 'All radiolabeled PDGF isoforms specificall... | |
medium_divergent_branch_05649 | The protein NONO interacts with multiple partners. One specific interaction is supported by evidence stating: 'Here we show that a specific splicing factor interacts with p54nrb, a highly related protein first identified based on cross-reactivity to antibodies against the yeast second-step splicing factor Prpl8.' Given... | Splicing factor, proline- and glutamine-rich | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05649","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein NONO interacts with multiple partners. One specific interaction is supported by evidence stating: 'Here we show that a specific splicing ... | |
medium_divergent_branch_05650 | CALCA is associated with multiple biological processes. One of these processes is supported by evidence showing that CALCA induces both endothelial proliferation and migration in a dose- and time-dependent manner. Which cell type is the target of movement in the biological process linked to CALCA via the 'results in mo... | endothelial cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05650","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CALCA is associated with multiple biological processes. One of these processes is supported by evidence showing that CALCA induces both endothelial p... | |
medium_divergent_branch_05652 | TRIM65 interacts with multiple genes. One of these interaction partners is characterized by experimental evidence showing that it directly interacts with VCAM-1 protein and directs its polyubiquitination, a mechanism by which it controls monocyte adherence and infiltration into tissues during inflammation. Which diseas... | meningioma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05652","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM65 interacts with multiple genes. One of these interaction partners is characterized by experimental evidence showing that it directly interacts ... | |
medium_divergent_branch_05653 | EPS15 interacts with multiple genes. One specific interaction is supported by evidence stating: 'By coimmunoprecipitation and immunofluorescence we show interaction of the gap junction protein alpha-1 with Eps15 and colocalization of these proteins mainly at the plasma membrane.' Which disease is therapeutically linked... | hypertensive disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05653","source_qa_id":"medium_divergent_branch_06127","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"EPS15 interacts with multiple genes. One specific interaction is supported by evidence stating: '... |
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