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medium_divergent_branch_05310 | USP22 interacts with multiple proteins. One specific interaction is characterized by the partner protein being stabilized through the removal of polyubiquitin chains conjugated onto it by USP22. Which protein corresponds to this interaction partner? | NAD-dependent protein deacetylase sirtuin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05310","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP22 interacts with multiple proteins. One specific interaction is characterized by the partner protein being stabilized through the removal of poly... | |
medium_divergent_branch_05311 | IRS1 interacts with multiple proteins. One specific interaction is supported by evidence that a specific protein directly binds to IRS1 and serves as a scaffold for mTOR-mediated phosphorylation of IRS1 on Ser636/639. Which protein product is encoded by the gene corresponding to this interacting partner? | Regulatory-associated protein of mTOR | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05311","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IRS1 interacts with multiple proteins. One specific interaction is supported by evidence that a specific protein directly binds to IRS1 and serves as... | |
medium_divergent_branch_05312 | TRIM69 interacts with multiple genes. One interaction is supported by evidence stating: 'We identify Serine/threonine-protein kinase 3 (MST2) as a new direct binding partner of TRIM69.' Which disease is associated with the gene identified as MST2? | combined immunodeficiency due to STK4 deficiency | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05312","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM69 interacts with multiple genes. One interaction is supported by evidence stating: 'We identify Serine/threonine-protein kinase 3 (MST2) as a ne... | |
medium_divergent_branch_05313 | PRKAB2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Our results indicate that AMPK is able to interact physically with this subunit and modify its phosphorylation status, supporting a possible role for AMPK in regulating proteasome function.' Which protein, connected to PRKAB2 vi... | 26S proteasome non-ATPase regulatory subunit 11 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05313","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKAB2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Our results indicate that AMPK is able to interact physic... | |
medium_divergent_branch_05314 | MTOR interacts with multiple genes. One of these interactions is supported by evidence stating that Oncogenic Ras directly binds to two components of the mTOR complex 2 (mTORC2)—specifically mTOR and MAPKAP1—to promote mTORC2 kinase activity at the plasma membrane. Which protein is encoded by the gene connected to MTOR... | GTPase NRas | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05314","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MTOR interacts with multiple genes. One of these interactions is supported by evidence stating that Oncogenic Ras directly binds to two components of... | |
medium_divergent_branch_05315 | STRN4 interacts with multiple genes. One of these interaction partners is identified in the literature as a STRIPAK complex component that serves as a generic binding partner for MAP4Ks and acts as a key regulator of the Hippo pathway in endometrial cancer development. Which disease is associated with this specific int... | B-cell chronic lymphocytic leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05315","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STRN4 interacts with multiple genes. One of these interaction partners is identified in the literature as a STRIPAK complex component that serves as ... | |
medium_divergent_branch_05316 | ZBTB33 interacts with multiple genes. One of these interaction partners is characterized by the following evidence: 'The T606-phosphorylated Kaiso (pT606-Kaiso) could directly bind to 14-3-3 family proteins, and depletion of T606 phosphorylation by T606A mutation abolished most of the Kaiso-14-3-3 binding.' Identify th... | papilloma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05316","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZBTB33 interacts with multiple genes. One of these interaction partners is characterized by the following evidence: 'The T606-phosphorylated Kaiso (p... | |
medium_divergent_branch_05317 | MIR222 is associated with multiple biological processes. One association is supported by evidence that treating CD34+ progenitors with miR-221 and miR-222 (via oligonucleotide transfection or lentiviral vector infection) leads to impaired proliferation and accelerated differentiation of endothelial cells. Which biologi... | hematopoietic stem cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05317","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR222 is associated with multiple biological processes. One association is supported by evidence that treating CD34+ progenitors with miR-221 and mi... | |
medium_divergent_branch_05318 | Histamine secretion by platelets is a specific type of biological process. One definition describes this process as 'the regulated release of histamine by a platelet or group of platelets.' Based on this description of regulated release, which broader biological process category does histamine secretion by platelets be... | cellular process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05318","source_qa_id":"medium_divergent_branch_01606","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"Histamine secretion by platelets is a specific type of biological process. One definition describ... | |
medium_divergent_branch_05319 | VPS41 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: 'A truncated construct containing only the hVps41 RING-H2 domain was found to associate with a class of intracellular vesicles that originated from the Golgi and showed par... | cytoplasmic vesicle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05319","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VPS41 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: '... | |
medium_divergent_branch_05320 | ERICH6 is enriched in multiple cell types. One of these cell types shows a mean expression of 5.07 TPM, a z-score of 1.81, and a fold enrichment of 4.01. Which cell type is the parent class (is_a) of the cell type exhibiting these specific expression statistics? | mature alpha-beta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05320","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERICH6 is enriched in multiple cell types. One of these cell types shows a mean expression of 5.07 TPM, a z-score of 1.81, and a fold enrichment of 4... | |
medium_divergent_branch_05321 | HES1 interacts with multiple proteins. One specific interaction is characterized by the fact that heterodimerization with HES1 is antagonized in part by a conserved N-terminal patch of negatively charged residues. Which cellular component is the protein exhibiting this specific interaction characteristic located in? | transcription regulator complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05321","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HES1 interacts with multiple proteins. One specific interaction is characterized by the fact that heterodimerization with HES1 is antagonized in part... | |
medium_divergent_branch_05323 | The gene TNFAIP3 interacts with multiple partners. One specific interaction is described as follows: Mechanistically, the de novo synthesized A20 protein interacts with tumor necrosis factor receptor-associated factor-interacting protein with forkhead-associated domain and thereby interferes with the association of thi... | TRAF-interacting protein with FHA domain-containing protein A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05323","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TNFAIP3 interacts with multiple partners. One specific interaction is described as follows: Mechanistically, the de novo synthesized A20 pro... | |
medium_divergent_branch_05324 | MTMR2 interacts with multiple proteins. One specific interaction partner is distinguished by experimental evidence stating: 'In this study, we identified a protein that specifically interacts with MTMR2 but not MTM1.' Which protein product is encoded by this specific interaction partner? | Myotubularin-related protein 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05324","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MTMR2 interacts with multiple proteins. One specific interaction partner is distinguished by experimental evidence stating: 'In this study, we identi... | |
medium_divergent_branch_05325 | The protein CHADL is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating that recombinant CHADL bound collagen in cell culture and inhibited in vitro collagen fibrillogenesis. Which molecular function, connected to this specific function... | extracellular matrix binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05325","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein CHADL is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence s... | |
medium_divergent_branch_05326 | Interleukin-6 production is enabled by multiple cell types. One of these cell types is described as a B-1 cell that facilitates the development of T-helper 2 (Th2) phenotype T cells and secretes high levels of interleukin-2, interleukin-10, interleukin-4, and interleukin-6. Which parent cell type is this specific cell ... | Be cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05326","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Interleukin-6 production is enabled by multiple cell types. One of these cell types is described as a B-1 cell that facilitates the development of T-... | |
medium_divergent_branch_05327 | USP35 interacts with multiple gene products. One of these interaction partners is characterized by evidence showing that USP35 binds to and deubiquitinates Aurora B, and inhibits the APC. Which protein is encoded by the gene corresponding to this specific interaction partner? | Aurora kinase B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05327","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP35 interacts with multiple gene products. One of these interaction partners is characterized by evidence showing that USP35 binds to and deubiquit... | |
medium_divergent_branch_05328 | OPTN interacts with multiple proteins. One interaction is supported by evidence stating that a non-catalytic region of the interacting partner is required for direct binding to optineurin. In which cellular component is this specific interacting partner located? | cytosol | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05328","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"OPTN interacts with multiple proteins. One interaction is supported by evidence stating that a non-catalytic region of the interacting partner is req... | |
medium_divergent_branch_05329 | PAN3 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that human [interaction partner] proteins recruit the PAN2-PAN3 and CCR4-CAF1-NOT deadenylase complexes through direct interactions with PAN3 and NOT1, respectively.' Which protein is encoded by the gene corresponding to ... | Trinucleotide repeat-containing gene 6A protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05329","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PAN3 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that human [interaction partner] proteins recruit ... | |
medium_divergent_branch_05330 | T cell cytokine production is enabled by more than one cell type. Evidence for one of these connections describes a recently activated type I NK T cell that secretes interferon-gamma and interleukin-4, and exhibits a phenotype of CD4-negative, CD8-negative, CD69-positive, and downregulated NK markers. Which cell type i... | CD4-negative, CD8-negative type I NK T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05330","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"T cell cytokine production is enabled by more than one cell type. Evidence for one of these connections describes a recently activated type I NK T ce... | |
medium_divergent_branch_05331 | The biological process 'regulation of bile acid biosynthetic process' is defined as any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the formation of bile acids. This process is a subtype of a broader regulatory process. Which biological process is directly r... | steroid biosynthetic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05331","source_qa_id":"medium_divergent_branch_02775","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'regulation of bile acid biosynthetic process' is defined as any process t... | |
medium_divergent_branch_05332 | In a study of Orthohepevirus A infection in hepatocytes (GSE135619), one downregulated gene exhibits a log2 fold change of approximately -1.60 and an adjusted p-value of approximately 0.0495. Which protein is encoded by this specific gene? | Paladin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05332","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"In a study of Orthohepevirus A infection in hepatocytes (GSE135619), one downregulated gene exhibits a log2 fold change of approximately -1.60 and an... | |
medium_divergent_branch_05333 | BAIAP2 (also known as IRSp53) interacts with multiple proteins. One specific interaction is described by the evidence: 'carboxy-terminal Src-homology-3 domain of IRSp53 binds to WAVE to form a trimolecular complex'. Which protein, linked to BAIAP2 by this specific binding interaction, is encoded by the gene in question... | Actin-binding protein WASF2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05333","source_qa_id":"medium_divergent_branch_04353","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"BAIAP2 (also known as IRSp53) interacts with multiple proteins. One specific interaction is descr... | |
medium_divergent_branch_05334 | PIAS4 interacts with multiple proteins. One of these interaction partners is a protein that is SUMOylated by PIASy (a SUMO E3 ligase upregulated in hypoxia) specifically at lysine residue 171. Which protein is encoded by the gene corresponding to this interaction partner? | von Hippel-Lindau disease tumor suppressor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05334","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PIAS4 interacts with multiple proteins. One of these interaction partners is a protein that is SUMOylated by PIASy (a SUMO E3 ligase upregulated in h... | |
medium_divergent_branch_05335 | ING2 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, using a proteomic approach by surface-enhanced laser desorption ionization and mass spectrometry (SELDI-MS) combined with immunological techniques, we show that the gene COPS2 interacts in vivo with the tumor suppressor p33ING1... | protein binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05335","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ING2 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, using a proteomic approach by surface-enhanced laser des... | |
medium_divergent_branch_05336 | Human gammaherpesvirus 4 is reported to downregulate multiple genes. One specific downregulation event is characterized by a log2 fold change of approximately -1.232 and an adjusted p-value of 0.03513. Which cell type is the target gene of this specific event enriched in? | neutrophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05336","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Human gammaherpesvirus 4 is reported to downregulate multiple genes. One specific downregulation event is characterized by a log2 fold change of appr... | |
medium_divergent_branch_05337 | MAP3K1 interacts with multiple genes. One interaction is supported by evidence stating: 'In this study we demonstrate that endogenous MEKK1 binds to endogenous ERK2, a MAP2K family member, and another MEKK level kinase, Raf-1, suggesting that it can assemble all three proteins of the ERK2 MAP kinase module.' Which dise... | polyploidy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05337","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP3K1 interacts with multiple genes. One interaction is supported by evidence stating: 'In this study we demonstrate that endogenous MEKK1 binds to ... | |
medium_divergent_branch_05338 | ETFRF1 is known to interact with multiple proteins. One specific interaction partner is described in evidence stating: 'We likewise discovered that LYRM5 interacts with and deflavinates the electron-transferring flavoprotein that shuttles electrons to coenzyme Q (CoQ).' Based on this description, which protein is the i... | Electron transfer flavoprotein subunit alpha, mitochondrial | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05338","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ETFRF1 is known to interact with multiple proteins. One specific interaction partner is described in evidence stating: 'We likewise discovered that L... | |
medium_divergent_branch_05340 | Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.167 and an adjusted p-value of 0.0477. In which cell is that selected gene enriched? | natural killer cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05340","source_qa_id":"medium_divergent_branch_02814","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch sho... | |
medium_divergent_branch_05341 | TAB2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here, we found that TAB2 could directly interact with this gene and function as a scaffold protein to facilitate the interaction between TAK1 and this gene.' Which disease is associated with the gene described by this eviden... | carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05341","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TAB2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here, we found that TAB2 could directly interact with... | |
medium_divergent_branch_05342 | BMP10 is associated with multiple biological processes. One association is supported by evidence stating that conditioned medium from cells transfected with wild-type or variant BMP10 induced hypertrophy in rat neonatal cardiomyocytes. Which biological process, connected to the process supported by this evidence, is th... | cardiac muscle hypertrophy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05342","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BMP10 is associated with multiple biological processes. One association is supported by evidence stating that conditioned medium from cells transfect... | |
medium_divergent_branch_05343 | DAZ1 interacts with multiple proteins. One specific interaction is described by the following evidence: 'Here, we show that this protein, a human homolog of Pumilio, a protein required to maintain germ line stem cells in Drosophila and Caenorhabditis elegans, forms a stable complex with DAZ through the same functional ... | Pumilio homolog 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05343","source_qa_id":"medium_divergent_branch_06487","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"DAZ1 interacts with multiple proteins. One specific interaction is described by the following evi... | |
medium_divergent_branch_05344 | PTPRC (CD45) interacts with multiple proteins. One interaction is supported by evidence stating that a phosphoprotein of unknown function that noncovalently associates with CD45 in lymphocytes is the interacting partner. Which protein is encoded by the gene corresponding to this specific interacting partner? | Protein tyrosine phosphatase receptor type C-associated protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05344","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTPRC (CD45) interacts with multiple proteins. One interaction is supported by evidence stating that a phosphoprotein of unknown function that noncov... | |
medium_divergent_branch_05345 | ID2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'All three Ids bound with high affinity to E proteins, but a much broader range of interactions was observed between Ids and the class B factors.' Which protein product is encoded by the gene that interacts with ID2 in this... | Transcription factor 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05345","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ID2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'All three Ids bound with high affinity to E protein... | |
medium_divergent_branch_05346 | RNF19A interacts with multiple proteins. One interaction partner is supported by evidence stating that Dorfin binds specifically to human ubiquitin-conjugating enzymes UbcH7 and a second enzyme via its RING-finger/IBR domain. Which protein product is encoded by the gene corresponding to this specific interaction partne... | Ubiquitin/ISG15-conjugating enzyme E2 L6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05346","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF19A interacts with multiple proteins. One interaction partner is supported by evidence stating that Dorfin binds specifically to human ubiquitin-c... | |
medium_divergent_branch_05347 | GNL3 interacts with multiple genes. One of these interacting partners is characterized by evidence stating: 'The N-terminal basic domain specifies nucleolar localization, the interaction with the tumor suppressor protein, and is required for the cell death caused by overexpression.' Which disease is causally linked to ... | preeclampsia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05347","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GNL3 interacts with multiple genes. One of these interacting partners is characterized by evidence stating: 'The N-terminal basic domain specifies nu... | |
medium_divergent_branch_05349 | NPPB interacts with multiple genes. One of these interactions is supported by evidence describing the determination of crystal structures of NPR-C complexes with atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) to elucidate binding specificity. Which protein is encoded by the gene connected to NPPB ... | Atrial natriuretic peptide receptor 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05349","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NPPB interacts with multiple genes. One of these interactions is supported by evidence describing the determination of crystal structures of NPR-C co... | |
medium_divergent_branch_05350 | RPA2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Co-immunoprecipitation experiments demonstrated that damaging treatments that block DNA replication substantially increased association between this protein and RPA in vivo, and a direct interaction between purified this ... | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05350","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RPA2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Co-immunoprecipitation experiments demonstrated th... | |
medium_divergent_branch_05351 | AGO2 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we show that the N-terminal GW-repeat-containing regions of all three TNRC6s interact with the four human Argonaute proteins (AGO1-AGO4).' Which cell type is the gene implicated in this specific evidence enriched in? | plasmacytoid dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05351","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AGO2 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we show that the N-terminal GW-repeat-containing regions... | |
medium_divergent_branch_05352 | TRIM22 interacts with multiple genes. One interaction is supported by evidence showing that TRIM22 binds to a negative regulator of NF-κB, specifically NF-κB inhibitor alpha (IκBα), and accelerates its degradation via K48-linked ubiquitination. Which disease is associated with this specific interacting partner through ... | nephritis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05352","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM22 interacts with multiple genes. One interaction is supported by evidence showing that TRIM22 binds to a negative regulator of NF-κB, specifical... | |
medium_divergent_branch_05353 | TP73 interacts with multiple proteins. One interaction is supported by evidence stating: 'Consistent with this hypothesis, we discovered that p73 interacts physically with various cyclins (A, B, D, and E).' Which protein, among those interacting with TP73, is the one described in this specific evidence, and what protei... | G1/S-specific cyclin-E1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05353","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TP73 interacts with multiple proteins. One interaction is supported by evidence stating: 'Consistent with this hypothesis, we discovered that p73 int... | |
medium_divergent_branch_05355 | ITSN1 interacts with multiple proteins. One interaction partner is supported by evidence stating that Intersectin and this partner are co-enriched in nerve terminals and are co-immunoprecipitated from brain extracts. Which protein is encoded by the gene corresponding to this interaction partner? | Son of sevenless homolog 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05355","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ITSN1 interacts with multiple proteins. One interaction partner is supported by evidence stating that Intersectin and this partner are co-enriched in... | |
medium_divergent_branch_05356 | PGK1 interacts with multiple proteins. One specific interaction is supported by evidence that EGFR- and ERK-activated casein kinase 2α (CK2α) phosphorylates nuclear phosphoglycerate kinase 1 (PGK1) at serine 256, facilitating its binding to a partner protein. Which gene encodes this specific interaction partner of PGK1... | Cell division cycle 7-related protein kinase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05356","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PGK1 interacts with multiple proteins. One specific interaction is supported by evidence that EGFR- and ERK-activated casein kinase 2α (CK2α) phospho... | |
medium_divergent_branch_05357 | SH3RF1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We now show that the protein encoded by the gene in question is a substrate as well as an activator of the E3 Ub ligase POSH.' Which protein, connected to SH3RF1 via this specific evidence, is encoded by the gene in question? | Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05357","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SH3RF1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We now show that the protein encoded by the gene in quest... | |
medium_divergent_branch_05358 | ARL4A interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Yeast two-hybrid screening and in vitro protein-interaction assays showed that hARL4 interacted with importin-alpha through its C-terminal NLS region and that the interaction was not nucleotide-dependent.' Which gene enc... | Importin subunit alpha-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05358","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARL4A interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Yeast two-hybrid screening and in vitro protein-i... | |
medium_divergent_branch_05359 | GATA3 is associated with multiple biological processes. One association is supported by evidence stating: 'These data suggest that GATA3 drives invasive breast cancer cells to undergo the reversal of epithelial-mesenchymal transition, leading to the suppression of cancer metastasis.' Which biological process, connected... | epithelial cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05359","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GATA3 is associated with multiple biological processes. One association is supported by evidence stating: 'These data suggest that GATA3 drives invas... | |
medium_divergent_branch_05361 | EFEMP1 interacts with multiple genes. One of these interaction partners is part of a set of eight proteins (including ERdj5 and PDIA6) whose interactions were verified at the western blotting level. Which gene, connected to EFEMP1 through this specific interaction, is also known to bind to another protein? | SHH | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05361","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EFEMP1 interacts with multiple genes. One of these interaction partners is part of a set of eight proteins (including ERdj5 and PDIA6) whose interact... | |
medium_divergent_branch_05362 | THAP7 is reported to interact with multiple proteins. One specific interaction is described by the following evidence: 'In this study we demonstrate that THAP7 associates with TAF-Ibeta in vitro and map their association domains to a C-terminal predicted coiled-coil motif on THAP7 and the central region of TAF-Ibeta.' ... | TATA box-binding protein-associated factor RNA polymerase I subunit B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05362","source_qa_id":"medium_divergent_branch_05316","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"THAP7 is reported to interact with multiple proteins. One specific interaction is described by th... | |
medium_divergent_branch_05363 | BLOC1S6 interacts with multiple proteins. One interaction is supported by evidence stating: 'Co-immunoprecipitation and immunodepletion experiments using an antibody to the interacting protein confirmed that this protein is a subunit of BLOC-1.' Which protein, connected to BLOC1S6 via this specific evidence, is the gen... | Biogenesis of lysosome-related organelles complex 1 subunit 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05363","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BLOC1S6 interacts with multiple proteins. One interaction is supported by evidence stating: 'Co-immunoprecipitation and immunodepletion experiments u... | |
medium_divergent_branch_05364 | Macrophage migration inhibitory factor (MIF) is associated with multiple biological processes. One specific association is supported by evidence that MIF binds to the extracellular domain of CD74, and that CD74 is required for MIF-induced activation of the extracellular signal-regulated kinase-1/2 MAP kinase cascade, c... | signal transduction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05364","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Macrophage migration inhibitory factor (MIF) is associated with multiple biological processes. One specific association is supported by evidence that... | |
medium_divergent_branch_05366 | HAND1 is associated with multiple molecular functions. One specific function is supported by evidence stating that HAND1 is recruited to the promoter via physical interaction with MEF2 proteins. Which broader molecular function category is this specific function a subclass of (is_a)? | DNA-binding transcription factor binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05366","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HAND1 is associated with multiple molecular functions. One specific function is supported by evidence stating that HAND1 is recruited to the promoter... | |
medium_divergent_branch_05368 | SENP3 interacts with multiple proteins. One interaction is supported by evidence including NLS predictions, co-immunoprecipitation, co-transfection of plasmids, and confocal microscopy, which indicates that SENP3 associates with a specific partner to promote its nuclear translocation. Which protein is encoded by the ge... | Sterol regulatory element-binding protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05368","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SENP3 interacts with multiple proteins. One interaction is supported by evidence including NLS predictions, co-immunoprecipitation, co-transfection o... | |
medium_divergent_branch_05369 | Paxillin (PXN) interacts with multiple proteins. One specific interaction is characterized by the following observation: 'Furthermore, whereas the (presumably indirect) interaction between paxillin and the C-terminal tail of talin led to dynamic FAs at the cell boundary, S85A paxillin did not bind talin and caused stab... | Talin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05369","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Paxillin (PXN) interacts with multiple proteins. One specific interaction is characterized by the following observation: 'Furthermore, whereas the (p... | |
medium_divergent_branch_05370 | SMARCAD1 interacts with multiple gene products. One interaction is supported by evidence stating: 'We identified the RNA polymerase III general transcription factor TFIIIC as an interaction partner of native SMARCAD1 in mouse and human models using endogenous co-immunoprecipitations.' Which protein is encoded by the ge... | General transcription factor 3C polypeptide 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05370","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMARCAD1 interacts with multiple gene products. One interaction is supported by evidence stating: 'We identified the RNA polymerase III general trans... | |
medium_divergent_branch_05371 | GRIA1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'We previously described that this interaction partner and GluR1 co-precipitate and that GluR1/this interaction partner co-expression both in HEK cells and neurons impairs CXCL8-induced cell migration.' Which gene interacts ... | ST13 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05371","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GRIA1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'We previously described that this interaction partne... | |
medium_divergent_branch_05372 | CITED2 interacts with multiple proteins. Evidence for one specific interaction indicates that CITED2 binds to the dimerization domain of the partner protein, a domain noted for being highly conserved in the TFAP2A/B family. Which protein product is encoded by the gene corresponding to this interacting partner? | Transcription factor AP-2 gamma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05372","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CITED2 interacts with multiple proteins. Evidence for one specific interaction indicates that CITED2 binds to the dimerization domain of the partner ... | |
medium_divergent_branch_05373 | ORC1 interacts with multiple genes. One interaction is supported by biochemical analyses showing that human ORC binds to a telomere sequence-binding protein involved in telomere protection and length homeostasis, specifically via the ORC1 subunit. Which disease is associated with this interacting gene as a biomarker? | adult T-cell leukemia/lymphoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05373","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ORC1 interacts with multiple genes. One interaction is supported by biochemical analyses showing that human ORC binds to a telomere sequence-binding ... | |
medium_divergent_branch_05374 | SCRIB interacts with multiple genes. Evidence for one of these interactions comes from HEK293 cell-based interactomic analyses of the Met1-Ub deubiquitinase, which revealed that this deubiquitinase interacts with SCRIB. Which gene is connected to SCRIB through this specific interaction? | NHERF2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05374","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SCRIB interacts with multiple genes. Evidence for one of these interactions comes from HEK293 cell-based interactomic analyses of the Met1-Ub deubiqu... | |
medium_divergent_branch_05375 | KMT2A (also known as MLL) interacts with multiple proteins. One interaction is supported by evidence stating that MLL interacts with RNA polymerase II (pol II) and colocalizes with RNA pol II at a subset of actively transcribed targets in vivo. Which protein, connected to KMT2A via this specific interaction evidence, i... | DNA-directed RNA polymerase II subunit RPB1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05375","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KMT2A (also known as MLL) interacts with multiple proteins. One interaction is supported by evidence stating that MLL interacts with RNA polymerase I... | |
medium_divergent_branch_05376 | The ligament of the liver is classified as a type of anatomy. Evidence indicates that this specific anatomical entity is a nonskeletal ligament that is part of the liver. Based on this description, which broader anatomical category does the ligament of the liver belong to? | abdominal segment element | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05376","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The ligament of the liver is classified as a type of anatomy. Evidence indicates that this specific anatomical entity is a nonskeletal ligament that ... | |
medium_divergent_branch_05377 | The mesangium is anatomically part of a specific structure. One candidate for this structure is described as 'The inner layer of the glomerulus, within the basement membrane surrounding the glomerular capillaries.' Which anatomical entity is this candidate structure part of? | renal corpuscle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05377","source_qa_id":"medium_divergent_branch_01989","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The mesangium is anatomically part of a specific structure. One candidate for this structure is d... | |
medium_divergent_branch_05378 | RNF8 interacts with multiple proteins. One specific interaction is supported by evidence stating that a protein regulates the stability of DDR factors, including RNF8 and BARD1, in a ubiquitin-protealytic pathway, and chaperones the interaction between BARD1 and RNF8 via their RING domains to form a novel ternary compl... | Melanoma-associated antigen D1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05378","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF8 interacts with multiple proteins. One specific interaction is supported by evidence stating that a protein regulates the stability of DDR factor... | |
medium_divergent_branch_05380 | Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.197 and an adjusted p-value of 0.0036. Which disease has a genomic-alteration link with that selected gene? | coronary artery disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05380","source_qa_id":"medium_divergent_branch_05401","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Pegivirus C upregulates several genes. In the recorded experiment, one branch showed a log2 fo... | |
medium_divergent_branch_05381 | TP73 interacts with multiple genes. One specific interaction is supported by evidence stating: 'First, the binding between p73 and Hades was identified by co-immunoprecipitation experiments, and it was found that the Hades RING-finger domain mediates the interaction with p73.' Which disease is associated with the gene ... | cervical cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05381","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TP73 interacts with multiple genes. One specific interaction is supported by evidence stating: 'First, the binding between p73 and Hades was identifi... | |
medium_divergent_branch_05382 | HIPK2 interacts with multiple proteins. One specific interaction is characterized by the following mechanism: upon DNA damage, the interacting partner is phosphorylated at Ser119 by the ATM serine/threonine kinase. This phosphorylation event potentiates the binding of this partner to HIPK2, resulting in the nondegradat... | Speckle-type POZ protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05382","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HIPK2 interacts with multiple proteins. One specific interaction is characterized by the following mechanism: upon DNA damage, the interacting partne... | |
medium_divergent_branch_05383 | RIPK3 interacts with multiple proteins. One of these interaction partners is reported to associate with RIPK1, RIPK3, and the ubiquitin ligases cIAP1 and LUBAC in human HT29 cells. Which protein corresponds to this interaction partner? | Z-DNA-binding protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05383","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RIPK3 interacts with multiple proteins. One of these interaction partners is reported to associate with RIPK1, RIPK3, and the ubiquitin ligases cIAP1... | |
medium_divergent_branch_05384 | NOTCH1 interacts with multiple genes. One such interaction is supported by evidence stating: 'In this study, we found that endogenous transcription factor Ying Yang 1 was associated with exogenous N1IC in human K562 erythroleukemic cells.' Which disease is connected to this gene through a biomarker relationship? | carcinoma of esophagus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05384","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NOTCH1 interacts with multiple genes. One such interaction is supported by evidence stating: 'In this study, we found that endogenous transcription f... | |
medium_divergent_branch_05385 | ATOX1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We use yeast and mammalian two-hybrid systems, along with an in vitro assay to demonstrate a specific, copper-dependent interaction between the six metal-binding domains of the WD and the Menkes disease protein ATPases and the cy... | Copper-transporting ATPase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05385","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATOX1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We use yeast and mammalian two-hybrid systems, along with ... | |
medium_divergent_branch_05386 | PLCB2 interacts with multiple genes. One of these interacting partners is characterized by evidence stating: 'The kinase domain of this protein directly associates with the C2 domain of phospholipase C (PLC).' Which disease is associated with this specific interacting gene? | amyotrophic lateral sclerosis-parkinsonism-dementia complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05386","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PLCB2 interacts with multiple genes. One of these interacting partners is characterized by evidence stating: 'The kinase domain of this protein direc... | |
medium_divergent_branch_05387 | TOMM70A is associated with multiple cellular components via the 'located in' relationship. One piece of evidence states: 'In this study, we identified translocases of outer membrane 70 (Tom70), a mitochondrial import receptor.' Based on this evidence, which cellular component is the correct location for TOMM70A, and wh... | cytoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05387","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TOMM70A is associated with multiple cellular components via the 'located in' relationship. One piece of evidence states: 'In this study, we identifie... | |
medium_divergent_branch_05389 | MYL2 interacts with multiple proteins. One interaction is characterized by evidence that the interacting protein binds to MLC2 (encoded by MYL2) following phosphorylation of MLC2 at Y118, a step that primes this binding and leads to subsequent MLC2 S15 phosphorylation dependent on the interacting protein. Which disease... | bone osteosarcoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05389","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MYL2 interacts with multiple proteins. One interaction is characterized by evidence that the interacting protein binds to MLC2 (encoded by MYL2) foll... | |
medium_divergent_branch_05390 | The fibrochondrocyte progenitor cell is a subtype of two distinct cell categories. One of these categories is described as a mesenchymal progenitor cell located in fibrocartilaginous tissues, along the fibrochondrocytic differentiation pathway, that co-expresses both fibrochondrocyte markers (COL1A1, COL3A1) and mesenc... | motile cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05390","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The fibrochondrocyte progenitor cell is a subtype of two distinct cell categories. One of these categories is described as a mesenchymal progenitor c... | |
medium_divergent_branch_05391 | FOCAD interacts with multiple proteins. One interaction is supported by evidence stating: 'Using a yeast two-hybrid screen and pull-down assays, tubulin beta-6 and other tubulin family members were identified as novel focadhesin-interacting partners.' Which protein, encoded by the gene connected to FOCAD via this speci... | Tubulin beta-6 chain | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05391","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOCAD interacts with multiple proteins. One interaction is supported by evidence stating: 'Using a yeast two-hybrid screen and pull-down assays, tubu... | |
medium_divergent_branch_05392 | WIPF2 interacts with multiple proteins. One interaction is supported by evidence stating: 'In addition, WIRE was able to bind the PDGF receptor substrate [interacting partner].' Which protein product is encoded by the gene corresponding to this specific interacting partner? | Cytoplasmic protein NCK2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05392","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WIPF2 interacts with multiple proteins. One interaction is supported by evidence stating: 'In addition, WIRE was able to bind the PDGF receptor subst... | |
medium_divergent_branch_05394 | The sphenoid cartilage element is a subtype of two distinct anatomical structures. One of these parent structures is characterized by being composed primarily of cartilage tissue. Which anatomical structure is the sphenoid cartilage element a subtype of, given this tissue composition clue? | endochondral element | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05394","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The sphenoid cartilage element is a subtype of two distinct anatomical structures. One of these parent structures is characterized by being composed ... | |
medium_divergent_branch_05395 | VAMP7 is implicated in multiple biological processes. One specific connection is supported by evidence showing that in permeabilized cells, anti-VAMP-7 antibodies (but not anti-VAMP-8) impaired the secretion of mediators such as eosinophil peroxidase and eosinophil-derived neurotoxin in a dose-dependent manner. Which b... | leukocyte degranulation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05395","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VAMP7 is implicated in multiple biological processes. One specific connection is supported by evidence showing that in permeabilized cells, anti-VAMP... | |
medium_divergent_branch_05396 | NUTF2 interacts with multiple genes. One interaction is supported by evidence stating: 'We have now found that immobilized recombinant p58 and p54 also can deplete nuclear transport activity from cytosol, and that p62, p58, and p54 bind directly to the cytosolic nuclear import factors p97 and NTF2.' Which disease is as... | dystonia 37, early-onset, with striatal lesions | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05396","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NUTF2 interacts with multiple genes. One interaction is supported by evidence stating: 'We have now found that immobilized recombinant p58 and p54 al... | |
medium_divergent_branch_05397 | SMURF1 interacts with multiple genes. One of these interaction partners is described as associating with transforming growth factor-beta type I receptor through the inhibitory Smad (I-Smad) Smad7, leading to their degradation. Which disease is associated with this specific interaction partner via a biomarker relationsh... | systemic sclerosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05397","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMURF1 interacts with multiple genes. One of these interaction partners is described as associating with transforming growth factor-beta type I recep... | |
medium_divergent_branch_05398 | HNF4A interacts with multiple genes. One specific interaction is supported by evidence stating: 'Furthermore, we found that the tumor suppressor protein in human embryonic kidney whole-cell extracts preferentially bound the ligand-binding domain of HNF4alpha1 and that the activation function 2 region was required for t... | inflammatory disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05398","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HNF4A interacts with multiple genes. One specific interaction is supported by evidence stating: 'Furthermore, we found that the tumor suppressor prot... | |
medium_divergent_branch_05399 | CHD3 is known to bind to multiple gene products. One specific interaction is supported by evidence stating: 'Functional analysis of the purified MeCP1 complex revealed that it preferentially binds, remodels, and deacetylates methylated nucleosomes.' Identify the gene product that interacts with the CHD3-binding partner... | MTA1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05399","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHD3 is known to bind to multiple gene products. One specific interaction is supported by evidence stating: 'Functional analysis of the purified MeCP... | |
medium_divergent_branch_05400 | ITGA5 forms a heterodimer with a specific beta subunit to create the alpha 5 beta 1 integrin complex. Evidence indicates that in migrating cells, a fraction of this endocytosed fibronectin receptor is sorted into multivesicular endosomes together with fibronectin and subsequently degraded in lysosomes. Which disease is... | hyperthyroidism | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05400","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ITGA5 forms a heterodimer with a specific beta subunit to create the alpha 5 beta 1 integrin complex. Evidence indicates that in migrating cells, a f... | |
medium_divergent_branch_05402 | GNAI2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Purification and biochemical characterization of recombinant Ric-8A revealed that it is a potent guanine nucleotide exchange factor for a subset of Galpha proteins including Galpha(q), Galpha(i1), and Galpha(o), but not Galpha(s)... | Chaperone Ric-8A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05402","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GNAI2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Purification and biochemical characterization of recombina... | |
medium_divergent_branch_05403 | The gene BEX2 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Moreover, our data suggests that BEX2 expression is required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of cyclin D1 and p21.' Which biological p... | regulation of cellular process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05403","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene BEX2 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Moreover, our data sugges... | |
medium_divergent_branch_05404 | MSH2 interacts with multiple proteins. One specific interaction was identified through immunoprecipitation experiments combined with mass spectrometry, which established that a specific DNA polymerase partners with MSH2, a mismatch repair protein associated with hereditary non-polyposis colorectal cancer. Which disease... | glioblastoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05404","source_qa_id":"medium_divergent_branch_04629","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MSH2 interacts with multiple proteins. One specific interaction was identified through immunoprec... | |
medium_divergent_branch_05406 | FUNDC1 interacts with multiple proteins. One specific interaction is described in a study identifying an interaction between the mitophagy protein FUNDC1 and a receptor subunit of the human SCF (SKP1/cullin/F-box protein) ubiquitin ligase complex, which acts as a gatekeeper for mitochondrial Ca2+ uptake and cardiac fun... | F-box/LRR-repeat protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05406","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FUNDC1 interacts with multiple proteins. One specific interaction is described in a study identifying an interaction between the mitophagy protein FU... | |
medium_divergent_branch_05407 | ATXN3 interacts with multiple proteins. One specific interaction is described by the statement: 'In this study, we identify [protein], an E3 ubiquitin-ligase responsible for a common familial form of Parkinson's disease, as a novel ataxin-3 binding partner.' Which protein is encoded by the gene corresponding to this sp... | E3 ubiquitin-protein ligase parkin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05407","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATXN3 interacts with multiple proteins. One specific interaction is described by the statement: 'In this study, we identify [protein], an E3 ubiquiti... | |
medium_divergent_branch_05408 | SAP30 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'By using a yeast two-hybrid screening system, SAP30 was identified as a protein that associates with this partner and it is able to enhance this partner-mediated repression in a dose-dependent manner.' What is the name o... | Transcriptional repressor protein YY1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05408","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SAP30 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'By using a yeast two-hybrid screening system, SAP... | |
medium_divergent_branch_05409 | The gene DRD1 is known to interact with multiple other genes. One specific interaction is supported by evidence stating: 'Using bioluminescence resonance energy transfer (BRET(2)), we further suggest the existence of a physical interaction between D1R and D3R.' Which protein is encoded by the gene that interacts with D... | D(3) dopamine receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05409","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene DRD1 is known to interact with multiple other genes. One specific interaction is supported by evidence stating: 'Using bioluminescence reson... | |
medium_divergent_branch_05410 | The gene AATF interacts with multiple partners. One interaction is supported by evidence stating: 'Here, we show that Che-1 binds directly to the tumor suppressor protein.' Which disease is genetically associated with the gene identified in this specific evidence? | inflammatory disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05410","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene AATF interacts with multiple partners. One interaction is supported by evidence stating: 'Here, we show that Che-1 binds directly to the tum... | |
medium_divergent_branch_05411 | BCOR interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'Indeed, mammalian two-hybrid assays, GST fusion protein pull-down assays, and co-immunoprecipitation assays showed that the zinc finger DNA-binding domain and the interaction domain of this protein are able to inter... | intervertebral disk degenerative disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05411","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BCOR interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'Indeed, mammalian two-hybrid assays, GST fus... | |
medium_divergent_branch_05412 | ING4 interacts with multiple proteins. One specific interaction partner is described as a histone acetyltransferase (HAT) that is required for normal progression through the S phase and is responsible for the majority of histone H4 acetylation in vivo. Which protein is encoded by the gene corresponding to this specific... | Histone acetyltransferase KAT7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05412","source_qa_id":"medium_divergent_branch_06521","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ING4 interacts with multiple proteins. One specific interaction partner is described as a histone... | |
medium_divergent_branch_05413 | MICU2 is associated with multiple biological processes. One specific association is supported by evidence stating that at low cytosolic calcium concentrations, the dominant effect of the protein largely shuts down MCU activity. Which broader biological process is the parent of this specific process in the ontology hier... | calcium ion transmembrane transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05413","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MICU2 is associated with multiple biological processes. One specific association is supported by evidence stating that at low cytosolic calcium conce... | |
medium_divergent_branch_05414 | TBL2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we identify transducin (beta)-like 2 (TBL2) as a novel [protein encoded by EIF2AK3]-binding protein.' Which protein, encoded by the gene interacting with TBL2 in this specific context, is the target of this interaction? | Eukaryotic translation initiation factor 2-alpha kinase 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05414","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TBL2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we identify transducin (beta)-like 2 (TBL2) as a novel... | |
medium_divergent_branch_05415 | The gene POLH interacts with multiple partners. One specific interaction partner is supported by evidence stating that it, along with BRCA2, interacts with Polη and is required to sustain the recruitment of Polη at blocked replication forks. Which protein is encoded by this interacting gene? | Partner and localizer of BRCA2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05415","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene POLH interacts with multiple partners. One specific interaction partner is supported by evidence stating that it, along with BRCA2, interact... | |
medium_divergent_branch_05416 | ELF3 interacts with multiple proteins. One specific interaction is characterized by biochemical evidence indicating that the physical binding between ELF3 and the partner protein inhibits the recruitment of that partner to specific androgen response elements within target gene promoters. Which protein, encoded by the g... | Androgen receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05416","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ELF3 interacts with multiple proteins. One specific interaction is characterized by biochemical evidence indicating that the physical binding between... | |
medium_divergent_branch_05417 | MIR223 is associated with multiple biological processes. One association is supported by evidence that adenoviral-mediated overexpression of miR-223 increases glucose uptake. Which biological process is positively regulated by the specific process linked to this glucose uptake evidence? | D-glucose import across plasma membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05417","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR223 is associated with multiple biological processes. One association is supported by evidence that adenoviral-mediated overexpression of miR-223 ... | |
medium_divergent_branch_05418 | The androgen receptor (AR) interacts with multiple proteins. One specific interacting partner is a nuclear protein that binds to AR via three important nuclear receptor interaction motifs and modulates AR ubiquitination, thereby influencing AR activity and stability. Which gene encodes this specific interacting protein... | Ubiquitin carboxyl-terminal hydrolase 26 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05418","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The androgen receptor (AR) interacts with multiple proteins. One specific interacting partner is a nuclear protein that binds to AR via three importa... | |
medium_divergent_branch_05419 | The gene DCX interacts with multiple partners. One specific interaction is supported by evidence stating: 'Here we report that a specific protein partner and DCX interact physically both in vitro and in vivo.' Which protein is encoded by the gene that interacts with DCX in this specific context? | Platelet-activating factor acetylhydrolase IB subunit beta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05419","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene DCX interacts with multiple partners. One specific interaction is supported by evidence stating: 'Here we report that a specific protein par... | |
medium_divergent_branch_05420 | PALB2 interacts with multiple genes. One of these interaction partners is described in evidence stating: 'We show here that this protein binds directly to a conserved chromodomain protein, MRG15, which is a component of histone acetyltransferase-deacetylase complexes.' Which cellular component is the gene identified by... | nucleolus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05420","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PALB2 interacts with multiple genes. One of these interaction partners is described in evidence stating: 'We show here that this protein binds direct... | |
medium_divergent_branch_05421 | DNMT1 interacts with multiple proteins. One of these interaction partners is known to colocalize with and directly interact with DNMT1, specifically monomethylating Lys-142 of DNMT1. Which protein, encoded by the gene corresponding to this specific interaction partner, is the target of the query? | Histone-lysine N-methyltransferase SETD7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05421","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DNMT1 interacts with multiple proteins. One of these interaction partners is known to colocalize with and directly interact with DNMT1, specifically ... |
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