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medium_divergent_branch_05196 | The biological process 'otic vesicle development' is defined as the progression of the otic vesicle from its formation to its mature structure. The otic vesicle is described as a transient embryonic structure formed during the development of the vertebrate inner ear. Based on this description, which broader biological ... | anatomical structure development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05196","source_qa_id":"medium_divergent_branch_07148","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'otic vesicle development' is defined as the progression of the otic vesic... | |
medium_divergent_branch_05198 | Amacrine cells are a type of neuron found in the vertebrate retina. They function to integrate, modulate, and interpose a temporal domain in the visual message presented to retinal ganglion cells, with which they synapse in the inner plexiform layer. Notably, they lack large axons. Based on this description, which broa... | central nervous system | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05198","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Amacrine cells are a type of neuron found in the vertebrate retina. They function to integrate, modulate, and interpose a temporal domain in the visu... | |
medium_divergent_branch_05200 | The biological process 'regulation of isotype switching' is defined as any process that modulates the frequency, rate, or extent of isotype switching. This process is a subtype of a broader regulatory process. Which biological process is directly regulated by this broader parent process? | immunoglobulin production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05200","source_qa_id":"medium_divergent_branch_02055","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'regulation of isotype switching' is defined as any process that modulates... | |
medium_divergent_branch_05202 | Zoledronic acid interacts with multiple drugs. One of these interacting drugs is associated with osteonecrosis of the jaw (ONJ), and its combination with bisphosphonates (BP) may increase the risk of developing lesions. Which disease is the drug exhibiting this specific safety profile indicated for? | gastrointestinal stromal tumor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05202","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Zoledronic acid interacts with multiple drugs. One of these interacting drugs is associated with osteonecrosis of the jaw (ONJ), and its combination ... | |
medium_divergent_branch_05203 | LRIF1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we report the cloning and characterization of a novel protein RIF1 (receptor interacting factor) that interacts with the protein encoded by the gene in question in vivo and in vitro.' Which protein, connected to LRIF1 via th... | Retinoic acid receptor alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05203","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LRIF1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we report the cloning and characterization of a novel... | |
medium_divergent_branch_05204 | MAP3K11 interacts with multiple proteins. One interaction is supported by evidence showing that a mutant of the interacting partner, unable to bind Akt2 (W489A), exhibits enhanced binding to MLK3, accompanied by increased activation of the JNK signaling pathway. Which protein, connected to MAP3K11 via this specific evi... | E3 ubiquitin-protein ligase SH3RF1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05204","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP3K11 interacts with multiple proteins. One interaction is supported by evidence showing that a mutant of the interacting partner, unable to bind A... | |
medium_divergent_branch_05205 | CSNK1D interacts with multiple genes. One interaction is supported by evidence stating: 'Cellular co-immunoprecipitation experiments and in vitro CK1 phosphorylation reactions indicate that CK1 interacted with and phosphorylated the gap junction protein encoded by GJA1, initially on serine(s) 325, 328, or 330.' Which d... | anemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05205","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CSNK1D interacts with multiple genes. One interaction is supported by evidence stating: 'Cellular co-immunoprecipitation experiments and in vitro CK1... | |
medium_divergent_branch_05206 | PTGDS interacts with multiple proteins. One interaction is supported by evidence stating: 'We show in this paper that lipocalin-type prostaglandin D2 (PGD2) synthase (L-PGDS) interacts intracellularly with the GPCR [Prostaglandin D2 receptor] in an agonist-independent manner.' Which protein, connected to PTGDS via this... | Prostaglandin D2 receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05206","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTGDS interacts with multiple proteins. One interaction is supported by evidence stating: 'We show in this paper that lipocalin-type prostaglandin D2... | |
medium_divergent_branch_05207 | MYBL2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'By using the yeast two-hybrid system, the zinc finger protein [ZNF622] was identified as one of the B-MYB interacting proteins that associates with the carboxyl-terminal conserved region of B-MYB.' Which protein, encoded... | Cytoplasmic 60S subunit biogenesis factor ZNF622 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05207","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MYBL2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'By using the yeast two-hybrid system, the zinc fi... | |
medium_divergent_branch_05208 | POP4 interacts with multiple proteins. One of these interaction partners has been reported to have a unique association with 7 of the 10 protein subunits of the RNase P complex, an endonuclease responsible for tRNA 5' maturation. Which protein, connected to POP4 via an interaction, is the subject of this specific evide... | MOB kinase activator 3C | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05208","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"POP4 interacts with multiple proteins. One of these interaction partners has been reported to have a unique association with 7 of the 10 protein subu... | |
medium_divergent_branch_05209 | TREM2 is associated with multiple biological processes. One specific process is supported by evidence stating that overexpression of wild-type TREM2 enhances the uptake of LDL, CLU, and APOE in heterologous cells, whereas disease variants of TREM2 are impaired in this activity. Which cellular component serves as the pr... | lipoprotein particle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05209","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TREM2 is associated with multiple biological processes. One specific process is supported by evidence stating that overexpression of wild-type TREM2 ... | |
medium_divergent_branch_05210 | ERCC5 interacts with multiple genes. One interaction is supported by evidence stating: 'The XPG protein stimulates the binding of HsNTH protein to its substrate and increases its glycosylase/AP lyase activity by a factor of approximately 2 through direct interaction between the two proteins.' Which protein is encoded b... | Endonuclease III-like protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05210","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERCC5 interacts with multiple genes. One interaction is supported by evidence stating: 'The XPG protein stimulates the binding of HsNTH protein to it... | |
medium_divergent_branch_05211 | NOD2 interacts with multiple proteins. One specific interaction was identified using a yeast 2-hybrid screen of an intestinal epithelial library and subsequently confirmed in mammalian cells via co-immunoprecipitation. Which disease is associated with the protein that fits this specific experimental description? | fibrosarcoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05211","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NOD2 interacts with multiple proteins. One specific interaction was identified using a yeast 2-hybrid screen of an intestinal epithelial library and ... | |
medium_divergent_branch_05212 | IRAK1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Furthermore, we found that TRAF6-mediated ubiquitination of IRAK1 requires the association of a specific protein with both IRAK1 and TRAF6.' Which protein, connected to IRAK1 via this interaction, is encoded by the gene ... | S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05212","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IRAK1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Furthermore, we found that TRAF6-mediated ubiquit... | |
medium_divergent_branch_05213 | SQSTM1 interacts with multiple proteins. One specific interaction is supported by experimental evidence stating: 'Furthermore, we selected several prey proteins from the interactome data and confirmed that a specific protein interacted with ancient ubiquitous protein 1 (AUP1), Fas-associated factor family member 2 (FAF... | Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05213","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SQSTM1 interacts with multiple proteins. One specific interaction is supported by experimental evidence stating: 'Furthermore, we selected several pr... | |
medium_divergent_branch_05214 | TRIB2 interacts with multiple proteins. One interaction partner was identified by mass spectrometry to directly interact with both TRIB2 and PSMB5. Which protein is encoded by the gene corresponding to this specific interaction partner? | Poly(rC)-binding protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05214","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIB2 interacts with multiple proteins. One interaction partner was identified by mass spectrometry to directly interact with both TRIB2 and PSMB5. W... | |
medium_divergent_branch_05215 | FGF1 interacts with multiple proteins. One interaction is supported by evidence stating that an in vitro-translated protein bound specifically to a fusion protein consisting of maltose-binding protein and aFGF. Which protein, encoded by the gene interacting with FGF1 in this specific manner, is the subject of this evid... | Acidic fibroblast growth factor intracellular-binding protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05215","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FGF1 interacts with multiple proteins. One interaction is supported by evidence stating that an in vitro-translated protein bound specifically to a f... | |
medium_divergent_branch_05216 | WNT6 is involved in multiple biological processes. One of these processes is supported by evidence that WNT6 overexpression promotes the mineralization of human dental pulp cells (hDPCs). Which biological process is positively regulated by this specific WNT6-associated process? | tooth mineralization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05216","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WNT6 is involved in multiple biological processes. One of these processes is supported by evidence that WNT6 overexpression promotes the mineralizati... | |
medium_divergent_branch_05217 | The protein MTRES1 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence that MTRES1 interacts with mitochondrial RNA polymerase (POLRMT). Given this specific interaction evidence, which cellular component is the parent term (via the 'is a' ... | intracellular organelle lumen | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05217","source_qa_id":"medium_divergent_branch_03140","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The protein MTRES1 is associated with multiple cellular components via the 'located in' relations... | |
medium_divergent_branch_05218 | The BAD protein interacts with multiple partners. One interaction is supported by evidence stating: 'Using the yeast two-hybrid system to search for BAD-binding proteins in an ovarian fusion cDNA library, we identified multiple cDNA clones encoding different isoforms of 14-3-3, a group of evolutionally conserved protei... | 14-3-3 protein epsilon | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05218","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The BAD protein interacts with multiple partners. One interaction is supported by evidence stating: 'Using the yeast two-hybrid system to search for ... | |
medium_divergent_branch_05219 | CHMP4B interacts with multiple proteins. One specific interaction involves a protein that is a paralogue of human Vps32/Snf7 and interacts with EAP20, a component of ESCRT-II. This interaction was observed via co-immunoprecipitation in HEK-293 cells. Which protein, connected to CHMP4B through this binding interaction, ... | Charged multivesicular body protein 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05219","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHMP4B interacts with multiple proteins. One specific interaction involves a protein that is a paralogue of human Vps32/Snf7 and interacts with EAP20... | |
medium_divergent_branch_05221 | Müller cells are a type of cell found in the retina. One specific classification describes them as astrocyte-like radial glial cells that extend vertically throughout the retina, with nuclei usually located in the middle of the inner nuclear layer. Based on this specific structural and functional description, which bro... | glial cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05221","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Müller cells are a type of cell found in the retina. One specific classification describes them as astrocyte-like radial glial cells that extend vert... | |
medium_divergent_branch_05222 | TDP2 is associated with multiple biological processes. One association is supported by evidence that TDP2 is required for normal levels of many gene transcripts in the developing mouse brain, including those linked to neurological function or disease, and for normal interneuron density in the mouse cerebellum. Which bi... | cell development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05222","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TDP2 is associated with multiple biological processes. One association is supported by evidence that TDP2 is required for normal levels of many gene ... | |
medium_divergent_branch_05223 | The protein POF1B is associated with multiple biological processes. One association is supported by evidence stating: 'Taken together, these data indicate that localisation of POF1B to tight junctions has a key role in the organisation of epithelial monolayers by regulating the actin cytoskeleton.' Identify the biologi... | cell morphogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05223","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein POF1B is associated with multiple biological processes. One association is supported by evidence stating: 'Taken together, these data ind... | |
medium_divergent_branch_05224 | E2F4 interacts with multiple genes. One of these interaction partners forms a complex with E2F4 and p107 or p130 in G(0)/early G(1) phase, and associates with B-Myb in late G(1)/S phase. Which disease is associated with this specific interaction partner through genomic alterations? | triple-negative breast carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05224","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"E2F4 interacts with multiple genes. One of these interaction partners forms a complex with E2F4 and p107 or p130 in G(0)/early G(1) phase, and associ... | |
medium_divergent_branch_05226 | SLC4A1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Gel overlay assays showed a specific interaction between a carbonic anhydrase isoform and AE1, AE2, and AE3.' Which protein, connected to SLC4A1 via this specific interaction evidence, is encoded by the gene in question? | Carbonic anhydrase 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05226","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SLC4A1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Gel overlay assays showed a specific interaction between ... | |
medium_divergent_branch_05227 | The GBA gene interacts with multiple partners. One specific interaction involves a component of the TRiC ring complex, a regulator of correct protein folding; reduced binding of GCase to this complex may result in defective maturation of nascent GCase in Gaucher disease cells. Which disease is associated with this spec... | intellectual developmental disorder with polymicrogyria and seizures | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05227","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The GBA gene interacts with multiple partners. One specific interaction involves a component of the TRiC ring complex, a regulator of correct protein... | |
medium_divergent_branch_05228 | RPL11 is known to interact with multiple proteins. One specific interaction is supported by evidence stating: 'By reciprocal co-immunoprecipitation, we further showed that there were at least two MDM2-ribosomal protein complexes in cells: MDM2-L5-L11-L23 and [Protein X]-MDM2-L5-L11-L23.' Based on this evidence, which p... | Cellular tumor antigen p53 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05228","source_qa_id":"medium_divergent_branch_02146","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"RPL11 is known to interact with multiple proteins. One specific interaction is supported by evide... | |
medium_divergent_branch_05229 | CREB1 interacts with multiple genes. One specific interaction is supported by evidence that S1P and PGE2 promote the direct interaction of CREB and a nuclear receptor, a process potentiated by C/EBPdelta, CREB-binding protein (CBP), and steroid receptor coactivator-3 (SRC-3). Which gene, connected to CREB1 via this spe... | ZNF217 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05229","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CREB1 interacts with multiple genes. One specific interaction is supported by evidence that S1P and PGE2 promote the direct interaction of CREB and a... | |
medium_divergent_branch_05230 | The biological process 'regulation of lymphocyte differentiation' is defined as any process that modulates the frequency, rate, or extent of lymphocyte differentiation. In the Gene Ontology hierarchy, this process is a subclass of which broader biological process? | regulation of hemopoiesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05230","source_qa_id":"medium_divergent_branch_03343","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'regulation of lymphocyte differentiation' is defined as any process that ... | |
medium_divergent_branch_05233 | SIK1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We demonstrated that a component of the GINS complex interacts with SIK1 and recruits it to the sites of DNA replication at the onset of S phase.' Which protein, connected to SIK1 via an interaction, is encoded by the gene associa... | DNA replication complex GINS protein SLD5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05233","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIK1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We demonstrated that a component of the GINS complex intera... | |
medium_divergent_branch_05234 | SOX4 interacts with multiple genes. One interaction was identified via yeast two-hybrid screening, which also reported a lamin protein, barrier to autointegration factor 1, and apolipoprotein C-III as novel interacting partners of SOX4. Which disease is associated with the gene that interacts with SOX4 through this spe... | acquired partial lipodystrophy | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05234","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SOX4 interacts with multiple genes. One interaction was identified via yeast two-hybrid screening, which also reported a lamin protein, barrier to au... | |
medium_divergent_branch_05235 | West Nile virus downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.022 and an adjusted p-value of 0.000737. Which disease is associated with that selected gene? | prostate cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05235","source_qa_id":"medium_divergent_branch_02580","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"West Nile virus downregulates several genes. In the recorded experiment, one branch showed a l... | |
medium_divergent_branch_05236 | IQGAP1 is associated with multiple biological processes. One association is supported by evidence stating: 'More important, the siRNA-mediated silencing of IQGAP1 significantly delayed cell cycle progression through S phase and G2/M in NIH 3T3 cells released from thymidine block.' Which biological process is a parent t... | regulation of cell cycle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05236","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IQGAP1 is associated with multiple biological processes. One association is supported by evidence stating: 'More important, the siRNA-mediated silenc... | |
medium_divergent_branch_05237 | MEF2A interacts with multiple proteins. One of these interaction partners is reported to associate with MEF2A in the nucleus. Which protein, encoded by a gene connected to MEF2A via an interaction, is described by this nuclear association evidence? | Histone deacetylase 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05237","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MEF2A interacts with multiple proteins. One of these interaction partners is reported to associate with MEF2A in the nucleus. Which protein, encoded ... | |
medium_divergent_branch_05238 | The gene KCNQ1 is associated with multiple biological processes. One association is supported by evidence stating: 'Therefore, K(V)LQT1 is the subunit that coassembles with minK to form I(Ks) channels and I(Ks) dysfunction is a cause of cardiac arrhythmia.' Identify the biological process linked to KCNQ1 by this specif... | regulation of blood circulation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05238","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene KCNQ1 is associated with multiple biological processes. One association is supported by evidence stating: 'Therefore, K(V)LQT1 is the subuni... | |
medium_divergent_branch_05239 | FBN1 is associated with multiple biological processes via the 'involved in' relationship. One such association is supported by evidence stating that the soluble N-terminal half of fibrillin-1 (rFBN1-N) strongly inhibited osteoclastogenesis. Which biological process, connected to the process linked to FBN1, is the targe... | osteoclast development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05239","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBN1 is associated with multiple biological processes via the 'involved in' relationship. One such association is supported by evidence stating that ... | |
medium_divergent_branch_05240 | VAMP2 interacts with multiple genes. One of these interaction partners is described as binding to VAMP and SNAP-23 in vitro, similar to other syntaxin family members. Which disease is associated with this specific gene? | familial hemophagocytic lymphohistiocytosis 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05240","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"VAMP2 interacts with multiple genes. One of these interaction partners is described as binding to VAMP and SNAP-23 in vitro, similar to other syntaxi... | |
medium_divergent_branch_05241 | FBXO17 interacts with multiple genes. One interaction is supported by evidence stating that all FBA proteins co-precipitated components of the canonical SCF complex (including Cullin1 and the interacting partner), whereas FBXO2 bound very little Cullin1, suggesting that FBXO2 may exist primarily as a heterodimer with t... | kidney cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05241","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXO17 interacts with multiple genes. One interaction is supported by evidence stating that all FBA proteins co-precipitated components of the canoni... | |
medium_divergent_branch_05242 | CNTN1 interacts with multiple proteins. One specific interaction is characterized by evidence stating: 'Co-immunoprecipitation experiments revealed that CNTN1 specifically interacts with this partner and promotes its proteasomal degradation by removing its K63-linked ubiquitination.' Which protein, encoded by the gene ... | Mitochondrial antiviral-signaling protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05242","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CNTN1 interacts with multiple proteins. One specific interaction is characterized by evidence stating: 'Co-immunoprecipitation experiments revealed t... | |
medium_divergent_branch_05243 | NOTCH1 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'we utilized signaling assays and biochemical studies of purified recombinant ligand and receptor molecules to investigate the differences in signaling behavior and intrinsic... | signaling receptor activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05243","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NOTCH1 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'we... | |
medium_divergent_branch_05244 | BCL2 is known to interact with multiple genes. One specific interaction partner is described as containing a motif similar to the BH3 domain (conserved in Bcl-2 family proteins) and a membrane-anchoring domain, and it interacts with Bcl-2 and Bcl-xL. Which gene is linked to this specific interaction partner by the rela... | STEAP3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05244","source_qa_id":"medium_divergent_branch_04694","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"BCL2 is known to interact with multiple genes. One specific interaction partner is described as c... | |
medium_divergent_branch_05245 | FBXL21 is reported to interact with multiple proteins. One specific interaction is characterized by a circadian pattern that is antiphasic to the accumulation of the interacting partner in skeletal muscle. Which protein is encoded by the gene corresponding to this specific interacting partner? | Telethonin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05245","source_qa_id":"medium_divergent_branch_02672","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"FBXL21 is reported to interact with multiple proteins. One specific interaction is characterized ... | |
medium_divergent_branch_05247 | EHMT2 interacts with multiple proteins. One of these interaction partners is characterized by the following evidence: 'Furthermore, amino acid sequence analysis of Wiz predicted two potential CtBP binding sites, and indeed CtBP binding to Wiz and association of CtBP with the Wiz/G9a/GLP complex was observed.' Which pro... | C-terminal-binding protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05247","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EHMT2 interacts with multiple proteins. One of these interaction partners is characterized by the following evidence: 'Furthermore, amino acid sequen... | |
medium_divergent_branch_05248 | HIF1A interacts with multiple proteins. One specific interaction involves a protein that is stabilized by SSAT1 (which shares 46% amino acid identity with SSAT2) to promote HIF-1alpha ubiquitination and degradation, whereas SSAT2 does not act via this stabilization mechanism. Which protein, linked to HIF1A by this spec... | Small ribosomal subunit protein RACK1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05248","source_qa_id":"medium_divergent_branch_01349","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"HIF1A interacts with multiple proteins. One specific interaction involves a protein that is stabi... | |
medium_divergent_branch_05249 | PPM1B interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Coimmunoprecipitation experiments indicated that PP2Cbeta-1 associates with the central region of the interacting partner.' Which protein is encoded by the gene corresponding to the interacting partner mentioned in this ... | Mitogen-activated protein kinase kinase kinase 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05249","source_qa_id":"medium_divergent_branch_02116","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PPM1B interacts with multiple proteins. One specific interaction is supported by evidence stating... | |
medium_divergent_branch_05250 | The gene NDN is known to interact with multiple proteins. One specific interaction involves Necdin binding to a partner protein via a domain containing two EF-hand motifs with confirmed Ca(2+) binding activity, as demonstrated by (45)Ca(2+) overlay assays. Which protein is encoded by the gene that corresponds to this s... | Nucleobindin-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05250","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NDN is known to interact with multiple proteins. One specific interaction involves Necdin binding to a partner protein via a domain containi... | |
medium_divergent_branch_05251 | ING1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, using a proteomic approach by surface-enhanced laser desorption ionization and mass spectrometry (SELDI-MS) combined with immunological techniques, we show that a specific protein interacts in vivo with the tumor suppressor ... | COP9 signalosome complex subunit 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05251","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ING1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, using a proteomic approach by surface-enhanced laser ... | |
medium_divergent_branch_05252 | THAP12 interacts with multiple genes. One of these interacting partners is described in evidence stating: 'We demonstrate that the mitogen-activated protein kinase-activated protein kinases (MAPKAPKs) MK2 and MAPKAPK3 are activated on virus infection and, in their active form, directly interact with the repressor of th... | patterned macular dystrophy 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05252","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"THAP12 interacts with multiple genes. One of these interacting partners is described in evidence stating: 'We demonstrate that the mitogen-activated ... | |
medium_divergent_branch_05253 | PARK7 interacts with multiple genes. One interaction is supported by evidence stating: 'We further verified that DJ-1 bound to a protein kinase in vitro and in vivo and colocalized with this kinase in the nuclei of NIH3T3 cells.' Which gene, connected to PARK7 via this specific interaction, is subsequently linked to an... | SEPTIN7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05253","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PARK7 interacts with multiple genes. One interaction is supported by evidence stating: 'We further verified that DJ-1 bound to a protein kinase in vi... | |
medium_divergent_branch_05254 | NFE2L2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here, we identified ubiquitin-specific-processing protease 11 in NRF2 complexes and confirmed an interaction between these two proteins.' Which cellular component is this interaction partner located in? | nucleus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05254","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NFE2L2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here, we identified ubiquitin-specific-processing p... | |
medium_divergent_branch_05255 | Fibronectin (FN1) interacts with multiple genes. One interaction is supported by evidence of direct binding between purified IGFBP-3 and fibronectin, as well as their strong co-localization in the cartilage matrix, which suggests they help regulate local IGF-I levels. Which disease is causally linked to the gene identi... | pancreatic neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05255","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Fibronectin (FN1) interacts with multiple genes. One interaction is supported by evidence of direct binding between purified IGFBP-3 and fibronectin,... | |
medium_divergent_branch_05256 | Prasugrel interacts with multiple drugs. One specific interaction is supported by evidence stating: 'In patients after stent implantation with atrial fibrillation, in which a triple therapy with dual antiplatelet drugs and an anticoagulant is indicated, bleeding is an issue. Recent data suggest that administering a thi... | pulmonary embolism | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05256","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Prasugrel interacts with multiple drugs. One specific interaction is supported by evidence stating: 'In patients after stent implantation with atrial... | |
medium_divergent_branch_05258 | A BioID interactome analysis of RFFL revealed interactions with the Rab11 effectors EHD1, a specific MICAL-like protein, and class I Rab11-FIPs. What is the name of the protein encoded by the gene corresponding to this specific MICAL-like protein? | MICAL-like protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05258","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"A BioID interactome analysis of RFFL revealed interactions with the Rab11 effectors EHD1, a specific MICAL-like protein, and class I Rab11-FIPs. What... | |
medium_divergent_branch_05259 | PPARG interacts with multiple proteins. One interaction is characterized by evidence that overexpression of the interacting protein sequesters PPARγ in the cytosol via binding of its scaffolding domain (CSD) to a conserved hydrophobic motif in helix 7 of PPARγ's ligand-binding domain. Which protein is encoded by the ge... | Caveolin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05259","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PPARG interacts with multiple proteins. One interaction is characterized by evidence that overexpression of the interacting protein sequesters PPARγ ... | |
medium_divergent_branch_05260 | ZAP70 interacts with multiple genes. One interaction is supported by evidence stating: 'Two molecules involved in signal transduction via the T cell antigen receptor, namely the protein-tyrosine kinase ZAP-70 and the proto-oncoprotein Vav, were found to be constitutively associated with tubulin in Jurkat T cells.' Whic... | scoliosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05260","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZAP70 interacts with multiple genes. One interaction is supported by evidence stating: 'Two molecules involved in signal transduction via the T cell ... | |
medium_divergent_branch_05262 | Angio-associated migratory cell protein (AAMP) interacts with multiple genes. One specific interaction is supported by evidence stating that AAMP was identified as a novel interacting partner of both TPα and TPβ. Which disease is therapeutically linked to the gene involved in this specific interaction? | kidney failure | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05262","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Angio-associated migratory cell protein (AAMP) interacts with multiple genes. One specific interaction is supported by evidence stating that AAMP was... | |
medium_divergent_branch_05263 | A proximal straight tubule epithelial cell is a subtype of which of the following cell types? Contextual clue: This cell type is defined as any epithelial cell of the proximal tubule that is part of some proximal straight tubule. | kidney loop of Henle epithelial cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05263","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"A proximal straight tubule epithelial cell is a subtype of which of the following cell types? Contextual clue: This cell type is defined as any epith... | |
medium_divergent_branch_05264 | The gene A2M interacts with multiple other genes. One specific interaction is supported by evidence stating: 'We present evidence for the direct binding of this protein to alpha(2)-macroglobulin (alpha(2)M) in human plasma to form a complex 18.5 nm in diameter.' Which protein is encoded by the gene that interacts with ... | Phosphatidylcholine-sterol acyltransferase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05264","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene A2M interacts with multiple other genes. One specific interaction is supported by evidence stating: 'We present evidence for the direct bind... | |
medium_divergent_branch_05265 | CIITA interacts with multiple proteins. One interaction partner is described in evidence stating that a protein encoded by the gene PSMC5 associates with the class II transactivator (CIITA) and with the MHC class II proximal promoter. Which protein, encoded by the gene connected to CIITA via this specific interaction, ... | 26S proteasome regulatory subunit 8 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05265","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CIITA interacts with multiple proteins. One interaction partner is described in evidence stating that a protein encoded by the gene PSMC5 associates ... | |
medium_divergent_branch_05266 | The gene POLR1G is associated with multiple interacting partners. One specific interaction involves CAST, which has been shown to interact in vivo and in vitro with a particular protein via a unique membrane-proximal region, but does not interact with CD3zeta or FcRgamma. Which protein, encoded by the gene connected to... | T-cell surface glycoprotein CD3 epsilon chain | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05266","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene POLR1G is associated with multiple interacting partners. One specific interaction involves CAST, which has been shown to interact in vivo an... | |
medium_divergent_branch_05267 | MECOM interacts with multiple genes. One specific interaction is supported by evidence stating: 'Using coimmunoprecipitation and fluorescence resonance energy transfer analysis, we found that the N-terminal domain of hypermethylated in cancer 1 interacts with the proximal set of zinc fingers of ecotropic viral integrat... | hyperparathyroidism | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05267","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MECOM interacts with multiple genes. One specific interaction is supported by evidence stating: 'Using coimmunoprecipitation and fluorescence resonan... | |
medium_divergent_branch_05268 | Orthohepevirus A is reported to upregulate multiple genes. One specific upregulation event is characterized by a log2 fold change of approximately 1.129 and an adjusted p-value of 0.02809. Identify the protein encoded by the gene associated with this specific statistical evidence. | E3 ubiquitin-protein ligase ZNRF2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05268","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Orthohepevirus A is reported to upregulate multiple genes. One specific upregulation event is characterized by a log2 fold change of approximately 1.... | |
medium_divergent_branch_05269 | GATA6 is associated with multiple biological processes. One specific association is supported by evidence stating that when overexpressed in immortalised human sebocytes, GATA6 triggers a junctional zone and sebaceous differentiation program whilst limiting lipid production and cell proliferation. Which biological proc... | sebaceous gland development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05269","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GATA6 is associated with multiple biological processes. One specific association is supported by evidence stating that when overexpressed in immortal... | |
medium_divergent_branch_05270 | The gene HIST1H3A is known to interact with multiple proteins. One specific interaction partner was identified in a study stating: 'We identified a specific chromodomain-containing protein as an interaction partner of histone H3 trimethylated on lysine 9 (H3K9me3).' Which protein is encoded by the gene that corresponds... | Chromodomain Y-like protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05270","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene HIST1H3A is known to interact with multiple proteins. One specific interaction partner was identified in a study stating: 'We identified a s... | |
medium_divergent_branch_05271 | The gene IL2RG is known to interact with multiple proteins. One specific interaction partner is distinguished by evidence stating that it, along with another kinase, was found to be selectively associated with the 'serine-rich' region of IL-2R beta and the carboxyl-terminal region of IL-2R gamma, respectively. Which pr... | Tyrosine-protein kinase JAK3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05271","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene IL2RG is known to interact with multiple proteins. One specific interaction partner is distinguished by evidence stating that it, along with... | |
medium_divergent_branch_05272 | ERCC1 interacts with multiple proteins. One specific interaction involves a partner protein that associates with ERCC1 (a subunit of the DNA repair endonuclease XPF-ERCC1) via a short acidic motif located outside of the partner's catalytic domain. Which disease is associated with this specific interacting partner throu... | Leber congenital amaurosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05272","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERCC1 interacts with multiple proteins. One specific interaction involves a partner protein that associates with ERCC1 (a subunit of the DNA repair e... | |
medium_divergent_branch_05273 | MYD88 interacts with multiple genes. One of these interacting partners is reported to associate with the receptor complex via interactions with both MYD88 and the IL-1 receptor accessory protein. Which disease is connected to this specific interacting gene through genomic alterations? | cutaneous melanoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05273","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MYD88 interacts with multiple genes. One of these interacting partners is reported to associate with the receptor complex via interactions with both ... | |
medium_divergent_branch_05274 | OPHN1 is associated with multiple biological processes. One association is supported by a study analyzing OPHN1-deficient human induced pluripotent stem cells (h-iPSCs) and their rescue via the ROCK inhibitor fasudil, which highlights the role of the ROCK pathway in neuronal differentiation. Which biological process, c... | neuron development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05274","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"OPHN1 is associated with multiple biological processes. One association is supported by a study analyzing OPHN1-deficient human induced pluripotent s... | |
medium_divergent_branch_05275 | GNAS interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We identified a protein member of the synembryn family as one of the interacting proteins.' Which molecular function is enabled by the gene corresponding to this specific interaction partner? | G-protein alpha-subunit binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05275","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GNAS interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We identified a protein member of the synembryn fa... | |
medium_divergent_branch_05276 | MAP3K11 interacts with multiple proteins. One interaction is characterized by evidence stating that TRAF6-mediated ubiquitination is required for the dissociation of inactive monomeric MLK3 from a scaffold protein, a process that facilitates the subsequent dimerization, autophosphorylation, and catalytic activation of ... | C-Jun-amino-terminal kinase-interacting protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05276","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP3K11 interacts with multiple proteins. One interaction is characterized by evidence stating that TRAF6-mediated ubiquitination is required for the... | |
medium_divergent_branch_05277 | MAPK12 interacts with multiple proteins. One interaction is supported by evidence stating: 'Yeast two-hybrid screening and in vitro and in vivo analyses further identified a specific p38gamma phosphatase through PDZ-mediated binding.' Which protein, connected to MAPK12 via a binding interaction, is the subject of this ... | Tyrosine-protein phosphatase non-receptor type 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05277","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAPK12 interacts with multiple proteins. One interaction is supported by evidence stating: 'Yeast two-hybrid screening and in vitro and in vivo analy... | |
medium_divergent_branch_05278 | GSTM3 interacts with multiple proteins. One of these interaction partners functions as an exchange factor that integrates Kelch-like ECH-associated protein 1 (KEAP1) into Cul3-RING ubiquitin ligases (CRL3). By binding to this partner, GSTM3 disrupts the NRF2/KEAP1 complex, thereby preventing NRF2 ubiquitination and deg... | Cullin-associated NEDD8-dissociated protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05278","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GSTM3 interacts with multiple proteins. One of these interaction partners functions as an exchange factor that integrates Kelch-like ECH-associated p... | |
medium_divergent_branch_05279 | USP4 interacts with multiple proteins. Evidence for one of these interactions indicates that the interacting partner forms a ternary complex with USP4 and SART3, which serves as a platform to deubiquitinate PRP31 and PRP3. Which protein is this interacting partner? | Ubiquitin carboxyl-terminal hydrolase 15 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05279","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"USP4 interacts with multiple proteins. Evidence for one of these interactions indicates that the interacting partner forms a ternary complex with USP... | |
medium_divergent_branch_05280 | PARD6A interacts with multiple protein kinase C isoforms. One specific interaction is supported by evidence describing the formation of an aPKC-ASIP/PAR-3-PAR-6 ternary complex that localizes to the apical junctional region of MDCK cells. Which protein is encoded by the gene corresponding to the aPKC isoform involved i... | Protein kinase C iota type | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05280","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PARD6A interacts with multiple protein kinase C isoforms. One specific interaction is supported by evidence describing the formation of an aPKC-ASIP/... | |
medium_divergent_branch_05281 | CLIC4 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating that CLIC4 colocalizes with AKAP350 and the tight junction protein ZO-1 in the apical region of polarized epithelial cells, suggesting a role in maintaining apical-basolater... | epithelium | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05281","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CLIC4 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating th... | |
medium_divergent_branch_05284 | PRDX4 interacts with multiple genes. One interaction is supported by evidence stating: 'We identified peroxiredoxin-4 (Prx-4) as a protein interacting with the beta isoform of the thromboxane A(2) receptor (TPbeta) by yeast two-hybrid analysis.' Which gene, connected to PRDX4 via this specific interaction, is also know... | TGM2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05284","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRDX4 interacts with multiple genes. One interaction is supported by evidence stating: 'We identified peroxiredoxin-4 (Prx-4) as a protein interactin... | |
medium_divergent_branch_05285 | The BLM protein interacts with multiple partners. One specific interaction partner is characterized by evidence showing that it, along with TOPOIIalpha and HSP90, interacts directly with BLM in vitro and modulates its helicase activity on telomere-like DNA substrates, but not on non-telomeric substrates. Which disease ... | thyroid tumor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05285","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The BLM protein interacts with multiple partners. One specific interaction partner is characterized by evidence showing that it, along with TOPOIIalp... | |
medium_divergent_branch_05286 | The protein NONO interacts with multiple genes. One of these interaction partners is identified in a study reporting that p54(nrb), a DBHS family protein, binds to BRG1, Brm, and a core subunit of the SWI/SNF chromatin remodeling complex, which are subunits of the SWI/SNF chromatin remodeling complex. Which disease is ... | Coffin-Siris syndrome 11 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05286","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein NONO interacts with multiple genes. One of these interaction partners is identified in a study reporting that p54(nrb), a DBHS family pro... | |
medium_divergent_branch_05287 | SATB1 interacts with multiple genes. One specific interaction partner is characterized by the fact that its binding to SATB1 is inhibited by phosphorylation. Which disease is associated with this specific interaction partner? | essential thrombocythemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05287","source_qa_id":"medium_divergent_branch_04549","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"SATB1 interacts with multiple genes. One specific interaction partner is characterized by the fac... | |
medium_divergent_branch_05288 | STARD3 interacts with multiple genes. One of these interaction partners forms a prototypical tethering complex with STARD3, where phosphorylation is instrumental for the formation of ER-endosome contacts and their sterol transfer function. Which disease is associated with this specific interaction partner through genom... | borderline personality disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05288","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STARD3 interacts with multiple genes. One of these interaction partners forms a prototypical tethering complex with STARD3, where phosphorylation is ... | |
medium_divergent_branch_05290 | TJP1 interacts with multiple genes. One interaction is supported by evidence that ZO-1, ZO-2, and ZO-3 bind to the COOH-terminal YV sequence of claudin-1 through a specific claudin family member via their PDZ1 domains in vitro. Which disease is associated with the gene identified by this specific binding evidence throu... | pseudohypoaldosteronism type 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05290","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TJP1 interacts with multiple genes. One interaction is supported by evidence that ZO-1, ZO-2, and ZO-3 bind to the COOH-terminal YV sequence of claud... | |
medium_divergent_branch_05291 | CD44 is associated with multiple molecular functions. One specific function is characterized by the entity acting as a cell surface receptor for the extracellular matrix macromolecule hyaluronan and mediating the endocytosis of hyaluronan, which leads to its subsequent degradation within lysosomes. Which biological pro... | vesicle-mediated transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05291","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD44 is associated with multiple molecular functions. One specific function is characterized by the entity acting as a cell surface receptor for the ... | |
medium_divergent_branch_05292 | EXOC5 interacts with multiple proteins. One of these interaction partners is described in the following evidence: 'Here, we show that GTP-bound [protein] interacts with Sec10, a subunit of the exocyst complex involved in docking of vesicles with the plasma membrane.' Which protein corresponds to this description? | ADP-ribosylation factor 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05292","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EXOC5 interacts with multiple proteins. One of these interaction partners is described in the following evidence: 'Here, we show that GTP-bound [prot... | |
medium_divergent_branch_05293 | PSMA2 interacts with multiple proteins. One interaction is supported by evidence stating: 'In the present study, we demonstrate that the 20S proteasome subunits alpha4 and alpha7 interact with each other as well as all the alpha-subunits in vivo and in vitro.' Which protein, encoded by the gene connected to PSMA2 via t... | Proteasome subunit alpha type-7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05293","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PSMA2 interacts with multiple proteins. One interaction is supported by evidence stating: 'In the present study, we demonstrate that the 20S proteaso... | |
medium_divergent_branch_05294 | CHMP4B interacts with multiple proteins. One interaction is supported by evidence that CHMP4B colocalizes and coimmunoprecipitates with the target protein, an interaction that is enhanced by actin stabilization. Which protein is this? | Myc box-dependent-interacting protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05294","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHMP4B interacts with multiple proteins. One interaction is supported by evidence that CHMP4B colocalizes and coimmunoprecipitates with the target pr... | |
medium_divergent_branch_05295 | IGHMBP2 is associated with multiple molecular functions. One line of evidence states: 'Our biochemical investigations show that IGHMBP2 associates physically with tRNAs and in particular with tRNA(Tyr).' Based on this specific evidence, which molecular function is directly supported? Furthermore, what is the parent mol... | RNA binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05295","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IGHMBP2 is associated with multiple molecular functions. One line of evidence states: 'Our biochemical investigations show that IGHMBP2 associates ph... | |
medium_divergent_branch_05296 | NLN is enriched in more than one cell type. Evidence for one of these connections reports a mean expression of 13.05 TPM, a z-score of 1.82, and a fold enrichment of 3.79. Which cell type, connected to NLN via enrichment, develops from another cell type? | intermediate monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05296","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NLN is enriched in more than one cell type. Evidence for one of these connections reports a mean expression of 13.05 TPM, a z-score of 1.82, and a fo... | |
medium_divergent_branch_05297 | WDR73 is associated with multiple biological processes. One association is supported by evidence stating that 'Fibroblasts from one affected child and WDR73-depleted podocytes displayed abnormal nuclear morphology, low cell viability, and alterations of the microtubule network.' Which cellular component is the result o... | nucleus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05297","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WDR73 is associated with multiple biological processes. One association is supported by evidence stating that 'Fibroblasts from one affected child an... | |
medium_divergent_branch_05298 | DCP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified human decapping enzyme 2 (hDCP2) as a binding protein with a specific autoantigen, being colocalized in processing bodies (p-bodies).' Which protein, connected to DCP2 via an interaction, is encoded by the gene assoc... | E3 ubiquitin-protein ligase TRIM21 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05298","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DCP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified human decapping enzyme 2 (hDCP2) as a binding... | |
medium_divergent_branch_05299 | The biological process 'positive regulation of inner ear auditory receptor cell differentiation' is a subtype of another biological process. One candidate parent process is defined by the evidence: 'Any process that activates or increases the frequency, rate or extent of auditory hair cell differentiation.' Which biolo... | inner ear receptor cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05299","source_qa_id":"medium_divergent_branch_05422","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'positive regulation of inner ear auditory receptor cell differentiation' ... | |
medium_divergent_branch_05300 | STK11 interacts with multiple proteins. One interaction is supported by evidence stating: 'Co-immunoprecipitation assay demonstrated that SIRT1, via its amino-terminus, binds to the DOC domain of the interacting partner, which then ubiquitinates LKB1 in the nuclear compartment of endothelial cells.' Which protein, enco... | E3 ubiquitin-protein ligase HERC2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05300","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STK11 interacts with multiple proteins. One interaction is supported by evidence stating: 'Co-immunoprecipitation assay demonstrated that SIRT1, via ... | |
medium_divergent_branch_05301 | MDM4 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that MDMX copurifies with 14-3-3, and DNA damage stimulates MDMX binding to 14-3-3.' Which protein, encoded by the gene interacting with MDM4 in this specific context, is the subject of this evidence? | 14-3-3 protein eta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05301","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MDM4 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that MDMX copurifies with 14-3-3, and DNA dama... | |
medium_divergent_branch_05302 | UBAP2 interacts with multiple proteins. One of these interactions is characterized by evidence that NSP3 binding to FMRPs disrupts their interaction with the stress granule component in question through direct competition with a peptide motif in that component, thereby preventing FMRP incorporation into stress granules... | RNA-binding protein FXR1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05302","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBAP2 interacts with multiple proteins. One of these interactions is characterized by evidence that NSP3 binding to FMRPs disrupts their interaction ... | |
medium_divergent_branch_05304 | MGRN1 interacts with multiple proteins. One interaction involves a cytoskeletal protein identified as alpha-tubulin. Which disease is associated with this specific interacting partner via genomic alterations? | amyotrophic lateral sclerosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05304","source_qa_id":"medium_divergent_branch_00595","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MGRN1 interacts with multiple proteins. One interaction involves a cytoskeletal protein identifie... | |
medium_divergent_branch_05305 | REG3A is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence stating: 'The expression of REG3A by keratinocytes is induced by interleukin-17 (IL-17) via activation of keratinocyte-encoded IL-17 receptor A (IL-17RA) and feeds back on keratin... | keratinocyte differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05305","source_qa_id":"medium_divergent_branch_00804","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"REG3A is associated with multiple biological processes via the 'involved in' relationship. One sp... | |
medium_divergent_branch_05306 | mmu-miR-29 regulates more than one cell type. One line of evidence states: 'Here we take advantage of tractable primary human lymphoid organ aggregate cultures to show that IL-21 directly suppresses HIV-1 replication, and identify microRNA-29 (miR-29) as an antiviral factor induced by IL-21 in CD4 T cells.' Which cell ... | mature alpha-beta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05306","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"mmu-miR-29 regulates more than one cell type. One line of evidence states: 'Here we take advantage of tractable primary human lymphoid organ aggregat... | |
medium_divergent_branch_05307 | PPM1A interacts with multiple proteins. One of these interactions is supported by evidence from Co-immunoprecipitation (Co-IP) and GST pull-down assays. Which protein, among those interacting with PPM1A, is the one for which this specific experimental evidence (Co-IP and GST pull-down) was reported? | E3 ubiquitin-protein ligase TRIM47 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05307","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PPM1A interacts with multiple proteins. One of these interactions is supported by evidence from Co-immunoprecipitation (Co-IP) and GST pull-down assa... | |
medium_divergent_branch_05308 | BCL2 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating that 'Bcl-2, in contrast, triggered carboxyfluorescein release at acidic pH only.' Which molecular function, connected to this specific function via the 'is_a' relationship, is ... | passive transmembrane transporter activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05308","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BCL2 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating that '... | |
medium_divergent_branch_05309 | CRTC1 interacts with multiple proteins. One interaction is supported by evidence stating that a specific kinase physically interacted with TORC1 and stimulated its nuclear translocation. Which protein is encoded by the gene corresponding to this interacting partner? | Mitogen-activated protein kinase kinase kinase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05309","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CRTC1 interacts with multiple proteins. One interaction is supported by evidence stating that a specific kinase physically interacted with TORC1 and ... |
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