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medium_divergent_branch_05766 | TAB3 interacts with multiple proteins. One interaction partner is described in evidence stating that it interacted with TAK1, TAB2, TAB3, and TRAF6 under both overexpression and physiological conditions. Which protein is encoded by the gene corresponding to this specific interaction partner? | Cytoplasmic dynein 2 intermediate chain 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05766","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TAB3 interacts with multiple proteins. One interaction partner is described in evidence stating that it interacted with TAK1, TAB2, TAB3, and TRAF6 u... | |
medium_divergent_branch_05768 | The protein SYK is associated with multiple cellular components. One specific association is supported by evidence stating: 'Finally, we provide evidence that both ZAP-70 and SYK can associate with the TCR after TCR stimulation.' Identify the cellular component linked to SYK by this evidence, and determine the broader ... | plasma membrane signaling receptor complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05768","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein SYK is associated with multiple cellular components. One specific association is supported by evidence stating: 'Finally, we provide evid... | |
medium_divergent_branch_05769 | WNT5B is implicated in multiple biological processes. One line of evidence notes that several Wnt proteins, including Wnt5a, Wnt5b, Wnt7a, and Wnt7b, are expressed in differentiating lens fiber cells. Based on this context, which biological process involving WNT5B is a component of a broader developmental process? | lens fiber cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05769","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WNT5B is implicated in multiple biological processes. One line of evidence notes that several Wnt proteins, including Wnt5a, Wnt5b, Wnt7a, and Wnt7b,... | |
medium_divergent_branch_05770 | IGF2R interacts with multiple genes. One of these interacting partners is described in the following evidence: 'We show that this gene binds directly to the mannose-6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) dependent on its glycosylation.' Which disease is causally linked to this specific interacti... | hyperplasia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05770","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IGF2R interacts with multiple genes. One of these interacting partners is described in the following evidence: 'We show that this gene binds directly... | |
medium_divergent_branch_05771 | ORC3 interacts with multiple proteins. One line of evidence lists the following binary interactions: HsOrc2-HsOrc3, HsOrc2-HsOrc4, HsOrc3-HsOrc4, HsOrc2-HsOrc6, and HsOrc3-HsOrc6. Which protein, connected to ORC3 via a binding interaction, is encoded by the gene in question? | Origin recognition complex subunit 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05771","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ORC3 interacts with multiple proteins. One line of evidence lists the following binary interactions: HsOrc2-HsOrc3, HsOrc2-HsOrc4, HsOrc3-HsOrc4, HsO... | |
medium_divergent_branch_05772 | ANK3 is known to interact with multiple proteins. One specific interaction is described by the following evidence: 'Here, we show that TGF-β signaling promotes the phosphorylation of this interaction partner, which enhances its interaction with ankyrin-G and stabilizes ankyrin-G in spines, leading to spine enlargement.... | Ubiquitin carboxyl-terminal hydrolase 9X | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05772","source_qa_id":"medium_divergent_branch_06236","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ANK3 is known to interact with multiple proteins. One specific interaction is described by the fo... | |
medium_divergent_branch_05773 | FLI1 interacts with multiple proteins. One interaction is supported by evidence stating: 'As the functional regulators of FLI-1 are largely unknown, we performed a yeast two-hybrid screen with FLI-1 and identified the SUMO E3 ligase [binding partner] as a novel in vitro and in vivo binding partner of FLI-1.' Which prot... | E3 SUMO-protein ligase PIAS2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05773","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FLI1 interacts with multiple proteins. One interaction is supported by evidence stating: 'As the functional regulators of FLI-1 are largely unknown, ... | |
medium_divergent_branch_05774 | MIR221 is associated with multiple biological processes. One association is supported by evidence stating that 'Down-regulation of p27Kip1 by miR-221 is critical for PDGF-mediated induction of cell proliferation.' Which biological process, connected to the process supported by this evidence via a 'positively regulates'... | vascular associated smooth muscle cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05774","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR221 is associated with multiple biological processes. One association is supported by evidence stating that 'Down-regulation of p27Kip1 by miR-221... | |
medium_divergent_branch_05776 | SUZ12 interacts with multiple proteins. One of these interaction partners is reported to associate with PRC2 in pluripotent cells, whereas PCL1 and SMAD3 preferentially associate with PRC2 in differentiating cells. Which protein is connected to SUZ12 through this interaction? | Zinc finger protein 281 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05776","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SUZ12 interacts with multiple proteins. One of these interaction partners is reported to associate with PRC2 in pluripotent cells, whereas PCL1 and S... | |
medium_divergent_branch_05777 | ATG7 interacts with multiple proteins. One specific interaction is characterized by the formation of an E1-substrate intermediate with the interacting protein (specifically the C572S mutant) and an E2-substrate intermediate with Atg3 (C264S). Which protein corresponds to this interacting partner? | Gamma-aminobutyric acid receptor-associated protein-like 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05777","source_qa_id":"medium_divergent_branch_05754","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ATG7 interacts with multiple proteins. One specific interaction is characterized by the formation... | |
medium_divergent_branch_05779 | DZIP1 is associated with multiple biological processes. One association is supported by evidence stating: 'The DZIP gene is expressed predominantly in human embryonic stem cells and fetal and adult germ cells; moreover, two DZIP protein isoforms colocalize with DAZ and/or DAZL proteins in these tissues.' Which biologic... | gamete generation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05779","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DZIP1 is associated with multiple biological processes. One association is supported by evidence stating: 'The DZIP gene is expressed predominantly i... | |
medium_divergent_branch_05781 | RAB8A interacts with multiple genes. One of these interaction partners was identified in a yeast two-hybrid assay demonstrating that a myosin V family member interacts with Rab8a, but not Rab8b. Which disease is associated with this specific interaction partner? | cholestasis, progressive familial intrahepatic, 10 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05781","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAB8A interacts with multiple genes. One of these interaction partners was identified in a yeast two-hybrid assay demonstrating that a myosin V famil... | |
medium_divergent_branch_05783 | RBM15B interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'Biochemical and subcellular localization studies showed that OTT3 and this partner also interact with each other in vivo, further supporting a shared function.' Which protein is encoded by this specific interactio... | RNA-binding protein 15 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05783","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RBM15B interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'Biochemical and subcellular localization s... | |
medium_divergent_branch_05784 | EIF4B interacts with multiple genes. One of these interaction partners has been identified through biochemical studies as an enzyme for which EIF4B is a bona fide substrate; this interaction stabilizes and enhances EIF4B activity. Which biological process is the gene encoding this specific interaction partner involved ... | protein deubiquitination | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05784","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF4B interacts with multiple genes. One of these interaction partners has been identified through biochemical studies as an enzyme for which EIF4B i... | |
medium_divergent_branch_05785 | Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.657 and an adjusted p-value of 0.0395. Which protein does that selected gene encode? | Large ribosomal subunit protein uL15m | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05785","source_qa_id":"medium_divergent_branch_04604","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch sho... | |
medium_divergent_branch_05786 | RNF139 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we show that the protein encoded by HM13 forms a complex with the ERAD factor Derlin1 and the E3 ubiquitin ligase TRC8 to cleave the unfolded protein response (UPR) regulator XBP1u.' Which protein, encoded by the gene inte... | Signal peptide peptidase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05786","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF139 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we show that the protein encoded by HM13 forms a co... | |
medium_divergent_branch_05787 | RNF180 interacts with multiple proteins. One specific interaction involves a protein that, when degraded by RNF180 via ubiquitination and proteasomal degradation (alongside TRIM24 and FOXC1), leads to inhibited proliferation, promoted apoptosis, and inhibited migration and invasion in colorectal cancer (CRC) cells. Whi... | Neurogenic locus notch homolog protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05787","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF180 interacts with multiple proteins. One specific interaction involves a protein that, when degraded by RNF180 via ubiquitination and proteasomal... | |
medium_divergent_branch_05788 | IL34 is associated with multiple biological processes. One association is supported by evidence stating: 'We report here that IL-34 induces the differentiation of monocytes into CD14(high) CD163(high) CD1a(-) Mφ (IL-34-Mφ).' Which biological process, connected to the process supported by this evidence via a 'positively... | macrophage differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05788","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IL34 is associated with multiple biological processes. One association is supported by evidence stating: 'We report here that IL-34 induces the diffe... | |
medium_divergent_branch_05790 | SUGT1 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'We found that the protein interacted with the essential outer-kinetochore protein SGT1 and stabilized its protein levels.' What is the full name of the protein encoded by the gene that interacts with SUGT1 and is descri... | PH domain leucine-rich repeat-containing protein phosphatase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05790","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SUGT1 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'We found that the protein interacted with the es... | |
medium_divergent_branch_05792 | BTRC interacts with multiple proteins. Evidence for one of these interactions states that point mutations changing the DAG motif to AAG or DAA eradicated both βTrCP binding and ubiquitylation. Which protein is encoded by the gene corresponding to this interacting partner? | M-phase inducer phosphatase 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05792","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BTRC interacts with multiple proteins. Evidence for one of these interactions states that point mutations changing the DAG motif to AAG or DAA eradic... | |
medium_divergent_branch_05793 | The microRNA mmu-miR-23a-3p regulates multiple cell types. One specific regulatory connection is supported by evidence from a cohort of advanced lung cancer patients, where miR-23a was found to be upregulated in tumor-infiltrating cytotoxic T lymphocytes (CTLs), with expression levels correlating with impaired antitumo... | effector T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05793","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The microRNA mmu-miR-23a-3p regulates multiple cell types. One specific regulatory connection is supported by evidence from a cohort of advanced lung... | |
medium_divergent_branch_05794 | RNF38 interacts with multiple proteins. One interaction is supported by evidence stating: 'Our further investigations showed that RNF38 interacted with this partner, and downregulated its expression by inducing its polyubiquitination.' Which protein, encoded by the gene corresponding to this interaction partner, is the... | LIM domain-binding protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05794","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF38 interacts with multiple proteins. One interaction is supported by evidence stating: 'Our further investigations showed that RNF38 interacted wi... | |
medium_divergent_branch_05795 | FBXO28 interacts with multiple proteins. One of these interaction partners is targeted for degradation via the ubiquitin-proteasome system because FBXO28 functions as an E3 ubiquitin ligase that directly binds to it. Which protein is this interaction partner? | Zinc finger protein SNAI2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05795","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXO28 interacts with multiple proteins. One of these interaction partners is targeted for degradation via the ubiquitin-proteasome system because FB... | |
medium_divergent_branch_05796 | TAB1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that while the [protein] RING domain is required for activation of TAK1, it is dispensable for interaction between the [protein] and the TAK1-TAB1-TAB2 complex.' Which protein, connected to TAB1 via this interaction, is e... | TNF receptor-associated factor 6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05796","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TAB1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that while the [protein] RING domain is required f... | |
medium_divergent_branch_05797 | The gene CDKN1C interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that the human p57 protein, like p21, contains a [protein]-binding domain within its C terminus that, when separated from its N-terminal CDK-cyclin binding domain, can prevent DNA replication in vitro and S... | DNA sliding clamp PCNA | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05797","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CDKN1C interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we show that the human p57 protein, like p2... | |
medium_divergent_branch_05798 | The naris is anatomically connected to two distinct structures via a 'part of' relationship. One of these connections is supported by evidence stating that the naris serves as the orifice for this structure and is the route by which odorants enter it. What is the broader biological category (via an 'is a' relationship)... | chemosensory system | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05798","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The naris is anatomically connected to two distinct structures via a 'part of' relationship. One of these connections is supported by evidence statin... | |
medium_divergent_branch_05799 | TRAIP interacts with multiple genes. One of these interactions is characterized by the following evidence: 'As an E3 ubiquitin ligase, TRIP negatively regulated the cellular levels of the interacting gene by directly binding to and promoting K48-linked polyubiquitination of the interacting gene.' Which disease is assoc... | myelofibrosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05799","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRAIP interacts with multiple genes. One of these interactions is characterized by the following evidence: 'As an E3 ubiquitin ligase, TRIP negativel... | |
medium_divergent_branch_05800 | HOXA5 is involved in a biological process that is supported by evidence stating: 'These studies show that constitutive expression of HOXA5 inhibits human erythropoiesis and promotes myelopoiesis.' Which biological process is negatively regulated by this specific process linked to HOXA5? | erythrocyte differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05800","source_qa_id":"medium_divergent_branch_06554","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"HOXA5 is involved in a biological process that is supported by evidence stating: 'These studies s... | |
medium_divergent_branch_05801 | Ciliary neurotrophic factor (CNTF) is associated with multiple biological processes. One specific association is supported by evidence that GDE3 inhibits oligodendrocyte progenitor cell (OPC) proliferation by stimulating CNTF-mediated signaling through the release of CNTFRα, the ligand-binding component of the CNTF-rec... | oligodendrocyte progenitor proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05801","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Ciliary neurotrophic factor (CNTF) is associated with multiple biological processes. One specific association is supported by evidence that GDE3 inhi... | |
medium_divergent_branch_05802 | UBE2S interacts with multiple proteins. One specific interaction is described as follows: Mechanistically, the interacting partner recruits ubiquitin-specific protease 15 to remove Lys63 (K63)-linked polyubiquitin chains of TBK1. Which protein corresponds to this interacting partner? | Ubiquitin carboxyl-terminal hydrolase 15 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05802","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBE2S interacts with multiple proteins. One specific interaction is described as follows: Mechanistically, the interacting partner recruits ubiquitin... | |
medium_divergent_branch_05803 | ICAM1 interacts with multiple genes. One specific interaction is characterized by the following mechanism: the partner protein interacts with ICAM1, leading to its autoubiquitination and clearance, which stabilizes LRP6, activates β-catenin signaling, and upregulates PD-L1 expression. Which disease is associated with g... | primary angle-closure glaucoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05803","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ICAM1 interacts with multiple genes. One specific interaction is characterized by the following mechanism: the partner protein interacts with ICAM1, ... | |
medium_divergent_branch_05804 | EVL interacts with multiple proteins. One interaction was identified using yeast two-hybrid screening of kidney libraries, which revealed partners of the alpha9-alpha10 repeats: the potential tumour suppressor Tes and EVL (Ena/vasodilator-stimulated phosphoprotein-like protein), both actin-binding proteins recruited at... | Sjogren syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05804","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EVL interacts with multiple proteins. One interaction was identified using yeast two-hybrid screening of kidney libraries, which revealed partners of... | |
medium_divergent_branch_05805 | The protein PYM1 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'This work identifies the ribosome-associated protein PYM as an EJC disassembly factor and defines its mechanism of function.' Which molecular function, connected t... | ribonucleoprotein complex binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05805","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein PYM1 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence st... | |
medium_divergent_branch_05806 | The gene COL7A1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study we demonstrate that monomeric laminin 5 binds the NH2-terminal NC-1 domain of type VII collagen.' Which protein, encoded by the gene connected to COL7A1 via this specific interaction, is the subject of thi... | Laminin subunit alpha-5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05806","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene COL7A1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In this study we demonstrate that monomeric lami... | |
medium_divergent_branch_05808 | The gene POLD1 is known to interact with multiple other genes. One specific interaction is supported by evidence stating: 'These assays revealed that the protein encoded by the interacting gene interacts with p125 as well as p50.' Based on this evidence, which protein is encoded by the gene that interacts with POLD1? | DNA polymerase delta subunit 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05808","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene POLD1 is known to interact with multiple other genes. One specific interaction is supported by evidence stating: 'These assays revealed that... | |
medium_divergent_branch_05809 | MLH1 interacts with multiple proteins. One specific interaction partner is described as being involved in mismatch repair (MMR) and recombination, directly interacting with MLH1 both in vivo and in vitro, and co-localizing with it to discrete nuclear foci. Which disease is associated with this specific interaction part... | adrenal gland neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05809","source_qa_id":"medium_divergent_branch_05065","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MLH1 interacts with multiple proteins. One specific interaction partner is described as being inv... | |
medium_divergent_branch_05810 | GPS2 interacts with multiple proteins. One interaction partner is part of a complex with TBL1, where they cooperatively bind to repression domain 1 of a nuclear receptor corepressor to form a heterotrimeric structure. This partner is also indirectly linked to HDAC3 via an extended SANT domain of this corepressor that a... | Nuclear receptor corepressor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05810","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GPS2 interacts with multiple proteins. One interaction partner is part of a complex with TBL1, where they cooperatively bind to repression domain 1 o... | |
medium_divergent_branch_05812 | Pancreatic goblet cells are a subtype of two distinct cell classes. One of these classes is defined by evidence stating it is part of the epithelium of the pancreatic duct. Which anatomical structure is the selected cell class part of? | exocrine pancreas epithelium | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05812","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Pancreatic goblet cells are a subtype of two distinct cell classes. One of these classes is defined by evidence stating it is part of the epithelium ... | |
medium_divergent_branch_05813 | JAK1 interacts with multiple proteins. One specific interaction partner is characterized by the following mechanism: Stimulation of EGFR induces Tyr701 phosphorylation of this partner and initiates complex formation involving this partner, STAT3, JAK1, and JAK2. Which disease is associated with genomic alterations in t... | esophageal candidiasis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05813","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"JAK1 interacts with multiple proteins. One specific interaction partner is characterized by the following mechanism: Stimulation of EGFR induces Tyr7... | |
medium_divergent_branch_05814 | The gene CBLC interacts with multiple proteins. One of these interaction partners is characterized by the following mechanism: the E3-ligase Cbl-3 interacts with the unphosphorylated form of this protein and dissociates from it upon its activation. Which protein is encoded by the gene that interacts with CBLC in this m... | Proto-oncogene tyrosine-protein kinase receptor Ret | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05814","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CBLC interacts with multiple proteins. One of these interaction partners is characterized by the following mechanism: the E3-ligase Cbl-3 in... | |
medium_divergent_branch_05816 | The protein DNA2 is associated with multiple molecular functions. One specific function is supported by evidence describing DNA2 as a multi-catalytic protein involved in the removal of single-strand DNA during mtDNA replication or the Long Patch Base Excision Repair pathway. What is the parent molecular function (conne... | catalytic activity, acting on a nucleic acid | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05816","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein DNA2 is associated with multiple molecular functions. One specific function is supported by evidence describing DNA2 as a multi-catalytic... | |
medium_divergent_branch_05817 | HMGB2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'We have mapped the interaction domains for both proteins and have shown that HMG2 and Oct2 interact via their HMG domains and POU homeodomains, respectively.' Which gene is connected to HMGB2 through this specific interacti... | TLE4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05817","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HMGB2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'We have mapped the interaction domains for both prot... | |
medium_divergent_branch_05818 | RBBP8 interacts with multiple genes. One of these interaction partners is described as directly participating in DNA end resection by interacting with CtIP and regulating CtIP recruitment to DNA damage sites. Which biological process is this specific interaction partner involved in? | mRNA splicing, via spliceosome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05818","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RBBP8 interacts with multiple genes. One of these interaction partners is described as directly participating in DNA end resection by interacting wit... | |
medium_divergent_branch_05819 | TPM4 is associated with multiple biological processes. One association is supported by evidence stating that insufficient TPM4 expression in human and mouse megakaryocytes resulted in a defect in the terminal stages of platelet production. Which biological process is connected to this specific process through a 'part o... | platelet morphogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05819","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TPM4 is associated with multiple biological processes. One association is supported by evidence stating that insufficient TPM4 expression in human an... | |
medium_divergent_branch_05820 | GATA3 interacts with multiple proteins. One specific interaction is supported by evidence stating that 'Protein-protein interaction analyses both in vitro and in vivo and chromatin immunoprecipitation (ChIP) assays showed that GATA-3 effects its transcriptional regulatory function through physical interactions with the... | Transcription factor Sp1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05820","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GATA3 interacts with multiple proteins. One specific interaction is supported by evidence stating that 'Protein-protein interaction analyses both in ... | |
medium_divergent_branch_05821 | ERLIN1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we report that the ER membrane protein SPFH1 and its homolog SPFH2 form a heteromeric approximately 2 MDa complex that binds to IP(3)R tetramers immediately after their activation and is required for their processi... | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05821","source_qa_id":"medium_divergent_branch_03832","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ERLIN1 interacts with multiple proteins. One specific interaction is supported by evidence statin... | |
medium_divergent_branch_05822 | RAB3A interacts with multiple proteins. One interaction is supported by evidence stating that the SHD domain of a specific protein preferentially interacts with the GTP-bound form of Rab27A and marginally with RAB3A and Rab6A, both in vitro and in intact cells. Which protein, encoded by the gene connected to RAB3A via ... | Synaptotagmin-like protein 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05822","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAB3A interacts with multiple proteins. One interaction is supported by evidence stating that the SHD domain of a specific protein preferentially int... | |
medium_divergent_branch_05823 | The gene LEPR interacts with multiple proteins. One interaction is supported by evidence stating: 'This decrease is mediated by the deubiquitinase ubiquitin-specific protease 8, which we show is in complex with LepRb.' Which protein is encoded by the gene that interacts with LEPR in this specific context? | Ubiquitin carboxyl-terminal hydrolase 8 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05823","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene LEPR interacts with multiple proteins. One interaction is supported by evidence stating: 'This decrease is mediated by the deubiquitinase ub... | |
medium_divergent_branch_05824 | EPHA2 is associated with multiple biological processes. One association is supported by evidence stating that ephrin-A1-Fc peptide treatment promoted epidermal cell colony compaction and stratification, which was associated with increased activity of the selected process. Which biological process is connected to this s... | skin development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05824","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EPHA2 is associated with multiple biological processes. One association is supported by evidence stating that ephrin-A1-Fc peptide treatment promoted... | |
medium_divergent_branch_05825 | The CFTR protein enables multiple molecular functions. One specific function is supported by evidence stating that purified, reconstituted CFTR monomers are sufficient to mediate regulated chloride conduction and ATPase activity. Which molecular function, connected to this specific activity via a 'part of' relationship... | ATP-dependent activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05825","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The CFTR protein enables multiple molecular functions. One specific function is supported by evidence stating that purified, reconstituted CFTR monom... | |
medium_divergent_branch_05826 | MXD4 interacts with multiple proteins. One of these interaction partners is described in literature as a novel Max-like protein that interacts with Mad1 and Mad4. Which protein, encoded by the gene connected to MXD4 via this specific interaction, is the subject of this description? | Max-like protein X | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05826","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MXD4 interacts with multiple proteins. One of these interaction partners is described in literature as a novel Max-like protein that interacts with M... | |
medium_divergent_branch_05827 | PSMC5 interacts with multiple genes. One of these interacting partners is described in a study stating: 'Using in vitro and in vivo interaction studies, we show in the present study that this protein interacts with human Sug1 [hSug1, also known as p45 or thyroid-hormone-receptor interacting protein ('TRIP1')], an ATPas... | stroke disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05827","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PSMC5 interacts with multiple genes. One of these interacting partners is described in a study stating: 'Using in vitro and in vivo interaction studi... | |
medium_divergent_branch_05828 | PTHLH interacts with multiple genes. One interaction involves a shared seven-transmembrane domain G protein-coupled receptor that binds both Parathyroid hormone (PTH) and PTH-related protein (PTHrP), and is predominantly located in bone and kidney. Which disease is associated with genomic alterations in this specific r... | Enchondromatosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05828","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTHLH interacts with multiple genes. One interaction involves a shared seven-transmembrane domain G protein-coupled receptor that binds both Parathyr... | |
medium_divergent_branch_05829 | DAXX is associated with multiple biological processes. One association is supported by evidence stating that the interaction of EAP1/DAXX with ETS1 leads to the repression of transcriptional activation of the MMP1 and BCL2 genes. Which biological process, connected to the process supported by this evidence via an 'is a... | regulation of macromolecule biosynthetic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05829","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DAXX is associated with multiple biological processes. One association is supported by evidence stating that the interaction of EAP1/DAXX with ETS1 l... | |
medium_divergent_branch_05830 | TAX1BP1 interacts with multiple proteins. One specific interaction was identified using a yeast two-hybrid system to screen for proteins that interact with TNFAIP3. Which disease is associated with this specific interacting protein as a biomarker? | myocarditis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05830","source_qa_id":"medium_divergent_branch_03973","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"TAX1BP1 interacts with multiple proteins. One specific interaction was identified using a yeast t... | |
medium_divergent_branch_05831 | The gene ATP8B4 shows significant enrichment in multiple cell types. One specific connection is supported by expression data reporting a mean expression of 19.62 TPM, a z-score of 2.06, and a fold enrichment of 6.78. Which cell type corresponds to this specific expression profile, and what is its immediate parent categ... | group 1 innate lymphoid cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05831","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ATP8B4 shows significant enrichment in multiple cell types. One specific connection is supported by expression data reporting a mean express... | |
medium_divergent_branch_05832 | NKX2-1 interacts with multiple genes. One of these interacting partners forms a direct physical interaction with TTF-1, as demonstrated by the ability of a GST-fusion protein of this partner to bind TTF-1 in cell extracts and purified systems. Which disease is associated with this specific interacting partner via a bio... | benign neoplasm of large intestine | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05832","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NKX2-1 interacts with multiple genes. One of these interacting partners forms a direct physical interaction with TTF-1, as demonstrated by the abilit... | |
medium_divergent_branch_05833 | GIPC1 interacts with multiple proteins. One specific interaction was characterized using a yeast two-hybrid system and an in vitro glutathione S-transferase fusion protein-binding assay, revealing that the binding involves a newly identified class I PDZ-binding domain located in the carboxyl terminus of the interacting... | Complement component C1q receptor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05833","source_qa_id":"medium_divergent_branch_02925","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"GIPC1 interacts with multiple proteins. One specific interaction was characterized using a yeast ... | |
medium_divergent_branch_05834 | PHLPP2 interacts with multiple genes. One of these interaction partners is known to interact via its PDZ domains with PHLPP1/PHLPP2 and to scaffold heterotrimeric complexes with PTEN. Which gene is this interaction partner? | CDK1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05834","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PHLPP2 interacts with multiple genes. One of these interaction partners is known to interact via its PDZ domains with PHLPP1/PHLPP2 and to scaffold h... | |
medium_divergent_branch_05835 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Human respirovirus 3 was found to upregulate a specific gene with a log2 fold change of 1.174 and an adjusted p-value of 0.03663. Which protein is encoded by this upregulated gene? | Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05835","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Human respirovirus 3 was found to upregulate a specific gene with a log2 fol... | |
medium_divergent_branch_05836 | ATXN3 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Both normal and expanded AT3 physiologically interacted with HDAC3 and a nuclear receptor corepressor in a SCA3 cell model and human pons tissue.' Which disease is associated with the gene identified in this specific intera... | lung adenocarcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05836","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATXN3 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Both normal and expanded AT3 physiologically interac... | |
medium_divergent_branch_05837 | CCNA1 is reported to interact with multiple proteins. One specific interaction is supported by evidence stating that when overexpressed in HeLa cells, cyclin A1 coimmunoprecipitates with the target protein. Which protein is encoded by the gene corresponding to this target protein? | M-phase inducer phosphatase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05837","source_qa_id":"medium_divergent_branch_03331","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"CCNA1 is reported to interact with multiple proteins. One specific interaction is supported by ev... | |
medium_divergent_branch_05838 | The gene ALOX5 is associated with multiple proteins via binding interactions. One specific interaction is supported by evidence stating: 'Direct interaction of 5-LO and LTC(4)S in ionophore-stimulated (but not un-stimulated) cells was demonstrated by BRET using GFP-5-LO and Rluc-LTC(4)S.' Which protein, among those con... | Leukotriene C4 synthase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05838","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ALOX5 is associated with multiple proteins via binding interactions. One specific interaction is supported by evidence stating: 'Direct inte... | |
medium_divergent_branch_05840 | FERMT2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here we identified a new direct interaction between Kindlin 2 and the active β-catenin.' Which disease is causally linked to the gene involved in this specific interaction? | proteinuria | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05840","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FERMT2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Here we identified a new direct interaction between... | |
medium_divergent_branch_05841 | The beta-2 adrenergic receptor (ADRB2) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Herein, we map the regions of the beta(2)-adrenergic receptor that are required for binding to gravin.' Which protein, among those interacting with ADRB2, is identified in this context, a... | A-kinase anchor protein 12 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05841","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The beta-2 adrenergic receptor (ADRB2) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Herein, we map t... | |
medium_divergent_branch_05842 | ATRX interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We show by coimmunoprecipitation that this localization is dependent on the association of ATRX with a histone variant, and that mutating the K4 residue of this variant significantly diminishes the ATRX and variant intera... | pediatric mesenchymal chondrosarcoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05842","source_qa_id":"medium_divergent_branch_07466","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ATRX interacts with multiple proteins. One specific interaction is supported by evidence stating:... | |
medium_divergent_branch_05843 | RACK1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified the receptor for activated C kinase (RACK1) as a new member of p73alpha-binding proteins.' Which cellular component is this interaction partner located in? | nucleus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05843","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RACK1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We identified the receptor for activated C kinase (RACK1) ... | |
medium_divergent_branch_05844 | In a study of Human mastadenovirus C infection in lung fibroblast cell lines (GSE120891), one downregulated gene exhibits a log2 fold change of -1.157 and an adjusted p-value of 0.04587. Which protein is encoded by this specific gene? | Homeobox protein Nkx-2.5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05844","source_qa_id":"medium_divergent_branch_01550","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"In a study of Human mastadenovirus C infection in lung fibroblast cell lines (GSE120891), one dow... | |
medium_divergent_branch_05845 | PRKG1 interacts with multiple proteins. One interaction is supported by evidence that PKGI-alpha binds directly to and phosphorylates RGS-2, an event that significantly increases the GTPase activity of G(q) and terminates PAR-1 signaling. Which protein product is encoded by the gene corresponding to this specific inter... | Regulator of G-protein signaling 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05845","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKG1 interacts with multiple proteins. One interaction is supported by evidence that PKGI-alpha binds directly to and phosphorylates RGS-2, an event... | |
medium_divergent_branch_05846 | RAD1 interacts with multiple proteins. One interaction partner is described as binding independently to the Rad9-Rad1-Hus1 complex (9-1-1) and the ATR activator TopBP1. Which protein, connected to RAD1 via this interaction, is encoded by the gene in question? | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05846","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAD1 interacts with multiple proteins. One interaction partner is described as binding independently to the Rad9-Rad1-Hus1 complex (9-1-1) and the AT... | |
medium_divergent_branch_05847 | Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.305 and an adjusted p-value of 0.0422. Which disease is associated with that selected gene? | neurodevelopmental disorder with poor growth and behavioral abnormalities | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05847","source_qa_id":"medium_divergent_branch_01135","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showe... | |
medium_divergent_branch_05848 | MUS81 interacts with multiple proteins. One of these interaction partners is described as forming a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associating with the MSH2/MSH3 mismatch repair complex, the telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kin... | Structure-specific endonuclease subunit SLX4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05848","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MUS81 interacts with multiple proteins. One of these interaction partners is described as forming a multiprotein complex with the ERCC4(XPF)-ERCC1, M... | |
medium_divergent_branch_05849 | PBRM1 interacts with multiple proteins. One of these interaction partners is a protein that is stimulated by the RLR pathway and interferon production, physically interacts with PBRM1, and induces PBRM1 protein destabilization by promoting its ubiquitination. Which gene encodes this specific interaction partner? | E3 ubiquitin/ISG15 ligase TRIM25 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05849","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PBRM1 interacts with multiple proteins. One of these interaction partners is a protein that is stimulated by the RLR pathway and interferon productio... | |
medium_divergent_branch_05851 | The gene P2RX7 is associated with multiple biological processes. One association is supported by evidence stating: 'The purinergic receptor P2X(7) is activated by extracellular adenosine 5'-triphosphate (ATP) and promotes the efficient release of interleukin-1 beta.' Identify the biological process linked to this speci... | interleukin-1 beta production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05851","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene P2RX7 is associated with multiple biological processes. One association is supported by evidence stating: 'The purinergic receptor P2X(7) is... | |
medium_divergent_branch_05852 | PSMC5 interacts with multiple genes. One of these interactions is supported by evidence stating: 'In addition, the Sug-1 component of 19S proteasome physically interacts with the tumor suppressor protein in vitro and in vivo.' Which disease is genetically associated with the gene identified by this specific evidence? | inflammatory disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05852","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PSMC5 interacts with multiple genes. One of these interactions is supported by evidence stating: 'In addition, the Sug-1 component of 19S proteasome ... | |
medium_divergent_branch_05853 | Moesin (MSN) interacts with multiple proteins. One specific interaction is supported by evidence showing that VCAM-1 interacted directly with moesin and ezrin in vitro, with all molecules colocalizing at the apical surface of the endothelium. Which protein is encoded by the gene that interacts with MSN in this specific... | Vascular cell adhesion protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05853","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Moesin (MSN) interacts with multiple proteins. One specific interaction is supported by evidence showing that VCAM-1 interacted directly with moesin ... | |
medium_divergent_branch_05854 | MIR221 is associated with multiple biological processes. One association is supported by evidence that treating CD34+ progenitors with miR-221 and miR-222 (via oligonucleotide transfection or lentiviral vector infection) leads to impaired proliferation and accelerated differentiation of endothelial cells. Which biologi... | hematopoietic stem cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05854","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR221 is associated with multiple biological processes. One association is supported by evidence that treating CD34+ progenitors with miR-221 and mi... | |
medium_divergent_branch_05855 | STING1 interacts with multiple proteins. One of these interaction partners is known to bind MITA and is localized to the mitochondria and endoplasmic reticulum. Which cell type is enriched for this specific interaction partner? | regulatory T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05855","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STING1 interacts with multiple proteins. One of these interaction partners is known to bind MITA and is localized to the mitochondria and endoplasmic... | |
medium_divergent_branch_05856 | LPAR2 interacts with multiple proteins. One specific interaction involves a PDZ-binding motif in the C-terminal tail of LPAR2, which allows it to complex with a specific scaffold protein. This scaffold protein is distinct from TRIP6 and Siva-1, which interact via a zinc finger-binding motif. Which protein is encoded by... | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05856","source_qa_id":"medium_divergent_branch_06471","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"LPAR2 interacts with multiple proteins. One specific interaction involves a PDZ-binding motif in ... | |
medium_divergent_branch_05857 | The gene NDN is known to bind to more than one protein. One specific interaction is supported by evidence stating: 'In addition, necdin and MAGE-G1 interacted with the p75 neurotrophin receptor via its distinct intracellular domains.' Which protein, encoded by the gene that NDN binds to in this specific context, is the... | Tumor necrosis factor receptor superfamily member 16 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05857","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NDN is known to bind to more than one protein. One specific interaction is supported by evidence stating: 'In addition, necdin and MAGE-G1 i... | |
medium_divergent_branch_05858 | HCFC1 interacts with multiple genes. One interaction is supported by evidence stating: 'We demonstrate that a large proportion of the signaling enzyme O-linked-N-acetylglucosaminyl transferase is complexed with HCF-1 and this interaction is essential for HCF-1 cleavage.' Which disease is associated with this interactio... | hepatocellular carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05858","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HCFC1 interacts with multiple genes. One interaction is supported by evidence stating: 'We demonstrate that a large proportion of the signaling enzym... | |
medium_divergent_branch_05859 | PSMA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In the present study, we demonstrate that the 20S proteasome subunits alpha4 and alpha7 interact with each other as well as all the alpha-subunits in vivo and in vitro.' Which protein, connected to PSMA1 via this interaction, enc... | Proteasome subunit alpha type-7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05859","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PSMA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'In the present study, we demonstrate that the 20S proteaso... | |
medium_divergent_branch_05860 | SIRT2 interacts with multiple genes. One of these interaction partners is reported to bind to SIRT2 and mediate its degradation by the 26S proteasome, a process that can be blocked by MG132 treatment. Which gene is connected to SIRT2 through this specific interaction? | SPOPL | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05860","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SIRT2 interacts with multiple genes. One of these interaction partners is reported to bind to SIRT2 and mediate its degradation by the 26S proteasome... | |
medium_divergent_branch_05861 | MIR130A is associated with multiple biological processes. One specific association is supported by evidence stating: 'MiR-130a improved the killing capacity of NK cells against NSCLC cells by targeting STAT3, laying a foundation for future studies on the roles and molecular basis of miR-130a in NK cell-based immunother... | natural killer cell activation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05861","source_qa_id":"medium_divergent_branch_01942","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MIR130A is associated with multiple biological processes. One specific association is supported b... | |
medium_divergent_branch_05862 | RFC3 interacts with multiple proteins. One interaction is supported by evidence describing the assembly of the RFC complex, where distinct subunit interactions were observed: both the 36- and 38-kDa subunits interacted with the 37-kDa subunit, and the 40-kDa subunit interacted with the 36-kDa subunit-37-kDa subunit sub... | Replication factor C subunit 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05862","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RFC3 interacts with multiple proteins. One interaction is supported by evidence describing the assembly of the RFC complex, where distinct subunit in... | |
medium_divergent_branch_05863 | TXNIP interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we report that thioredoxin interacting protein (TXNIP), a member of the tumor suppressor family, interacts with hEcd and decreases MDM2-mediated p53 ubiquitination, leading to p53 stabilization and an increase in p53 activity.... | positive regulation of transcription by RNA polymerase II | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05863","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TXNIP interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we report that thioredoxin interacting protein (TXNIP),... | |
medium_divergent_branch_05864 | RHOB is associated with multiple biological processes. One association is supported by evidence stating that 'The reduction in migration and cell elongation can be mimicked by overexpression of RHOB.' Identify the biological process linked to this specific association via an 'is a' relationship. | regulation of cell motility | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05864","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RHOB is associated with multiple biological processes. One association is supported by evidence stating that 'The reduction in migration and cell elo... | |
medium_divergent_branch_05865 | MAGI2 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating that MAGI-2 contains eight potential protein-protein interaction domains and is localized to tight junctions in the membrane of epithelial cells. Which cellular component is... | apical junction complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05865","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAGI2 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating th... | |
medium_divergent_branch_05866 | BCL2L1 interacts with multiple genes. One interaction is supported by evidence stating: 'In addition, treatment with TGF-beta induced binding of Bim, a proapoptotic Bcl-2 homology domain 3 (BH3)-only protein, to Bcl-X(L), which is dependent on the activation of Smad, and reduction in the expression of Bim by RNA interf... | myosin complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05866","source_qa_id":"medium_divergent_branch_00760","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"BCL2L1 interacts with multiple genes. One interaction is supported by evidence stating: 'In addit... | |
medium_divergent_branch_05868 | ACVR1 is involved in multiple biological processes. One such process is supported by evidence stating that RNA interference-mediated gene knockdown revealed osteoinductive BMP activities in human mesenchymal stem cells (hMSC) are elicited through type I receptors ACVR1 and BMPR1A, and type II receptors ACVR2A and BMPR2... | bone mineralization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05868","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ACVR1 is involved in multiple biological processes. One such process is supported by evidence stating that RNA interference-mediated gene knockdown r... | |
medium_divergent_branch_05869 | TP53BP1 interacts with multiple genes. One of these interactions is supported by evidence stating that 53BP1 and a specific partner form a stable complex required for their expression. Which gene, connected to TP53BP1 via this specific interaction, is also known to bind to another partner? | SDC4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05869","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TP53BP1 interacts with multiple genes. One of these interactions is supported by evidence stating that 53BP1 and a specific partner form a stable com... | |
medium_divergent_branch_05870 | TRAIP interacts with multiple genes. One of these interaction partners was identified in a yeast two-hybrid screen using an HaCaT cDNA library, which found that the RING finger protein TRIP (TRAF-interacting protein) interacts with the full-length form of this partner. Which cell type is the gene identified by this spe... | basophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05870","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRAIP interacts with multiple genes. One of these interaction partners was identified in a yeast two-hybrid screen using an HaCaT cDNA library, which... | |
medium_divergent_branch_05871 | MYCBP2 interacts with multiple genes. One of these interaction partners is described as an E3 ligase with a RING-Cys-Relay (RCR) domain that transfers ubiquitin from a specific E2 enzyme to a substrate via an esterification reaction. Which cellular component is the gene corresponding to this specific E2 enzyme located ... | extracellular exosome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05871","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MYCBP2 interacts with multiple genes. One of these interaction partners is described as an E3 ligase with a RING-Cys-Relay (RCR) domain that transfer... | |
medium_divergent_branch_05872 | TUBA1B interacts with multiple genes. Evidence for one of these interactions states: 'Microtubule sedimentation and cryo-electron microscopy with 3D reconstruction revealed that the basic N-terminal domain of EML4 mediated its binding to the acidic C-terminal tails of α- and β-tubulin on the microtubule surface.' Which... | multiple benign circumferential skin creases on limbs 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05872","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TUBA1B interacts with multiple genes. Evidence for one of these interactions states: 'Microtubule sedimentation and cryo-electron microscopy with 3D ... | |
medium_divergent_branch_05873 | MAGEA4 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we identify the cancer/testes antigen melanoma antigen-A4 (MAGE-A4) as a tumour cell-specific [protein]-binding partner and an activator of TLS.' Which protein, encoded by the gene connected to MAGEA4 via this spec... | E3 ubiquitin-protein ligase RAD18 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05873","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAGEA4 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we identify the cancer/testes antigen melan... | |
medium_divergent_branch_05874 | KIF11 (also known as Eg5) interacts with multiple genes. One interaction is supported by evidence stating: 'Here we report that the RNF20/40 complex, a major ubiquitin ligase catalysing histone H2B monoubiquitination, interacts with the motor protein Eg5 during mitosis and participates in spindle assembly.' Which gene,... | USP15 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05874","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KIF11 (also known as Eg5) interacts with multiple genes. One interaction is supported by evidence stating: 'Here we report that the RNF20/40 complex,... | |
medium_divergent_branch_05875 | EBNA1BP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'By using the yeast two-hybrid system we have identified a nucleolar [protein] binding protein (NoBP) which coimmunoprecipitated and colocalized with the [protein] in transfected COS-1 cells.' Which protein, connected to EBNA1B... | Fibroblast growth factor 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05875","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EBNA1BP2 interacts with multiple proteins. One interaction is supported by evidence stating: 'By using the yeast two-hybrid system we have identified... | |
medium_divergent_branch_05876 | The gene SHTN1 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 31.14 TPM, a z-score of 1.81, and a fold enrichment of 6.15. Which cell type corresponds to this specific statistical profile, and what is its immediate parent cell type in the classif... | monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05876","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SHTN1 is enriched in multiple cell types. One specific connection is supported by expression data showing a mean expression of 31.14 TPM, a ... | |
medium_divergent_branch_05877 | ZFP36L1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'In addition, we demonstrate that both ZFP36 and ZFP36L1 influence keratinocyte cell cycle, differentiation, and apoptosis in a distinct manner.' Identify the biological process linked to ZFP36L1 by this... | regulation of epithelial cell proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05877","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZFP36L1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'In addition, we demonstrate tha... | |
medium_divergent_branch_05879 | DISC1 interacts with multiple proteins. One interaction partner is described in evidence stating that DISC1 interacts via yeast two-hybrid, mammalian two-hybrid, and co-immunoprecipitation assays with several centrosomal and cytoskeletal proteins, specifically listing MIPT3, the protein in question, and NUDEL. Which pr... | Microtubule-associated protein 1A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05879","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DISC1 interacts with multiple proteins. One interaction partner is described in evidence stating that DISC1 interacts via yeast two-hybrid, mammalian... |
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