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medium_divergent_branch_05880 | RLN3 is reported to bind multiple receptors. One specific interaction is described in a study aiming to develop analogues of human relaxin-3 that selectively bind and activate its receptor. Which protein is encoded by the gene corresponding to this receptor? | Relaxin-3 receptor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05880","source_qa_id":"medium_divergent_branch_01807","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"RLN3 is reported to bind multiple receptors. One specific interaction is described in a study aim... | |
medium_divergent_branch_05881 | The protein Citron kinase (CIT) interacts with multiple partners. One specific interaction is supported by evidence stating: 'Using the yeast two hybrid system and overlay assays we identified a putative rho/rac effector, citron, which interacts with the GTP-bound forms of rho and rac1, but not with cdc42.' Based on th... | Rho-related GTP-binding protein RhoB | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05881","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein Citron kinase (CIT) interacts with multiple partners. One specific interaction is supported by evidence stating: 'Using the yeast two hyb... | |
medium_divergent_branch_05883 | HINT1 interacts with multiple proteins. One of these interaction partners is supported by evidence stating: 'Pull-down assays and co-immunoprecipitation experiments show that Hint1/PKCI directly binds to Pontin and Reptin.' Which protein, encoded by the gene connected to HINT1 via this specific interaction evidence, is... | RuvB-like 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05883","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HINT1 interacts with multiple proteins. One of these interaction partners is supported by evidence stating: 'Pull-down assays and co-immunoprecipitat... | |
medium_divergent_branch_05884 | PARD6A interacts with multiple proteins. One interaction partner is characterized by the presence of a PDZ domain and a Cdc42/Rac interactive binding (CRIB) motif, and it interacts with PARD6A and Cdc42 in a GTP-dependent manner. Which protein corresponds to this description? | Ras-related C3 botulinum toxin substrate 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05884","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PARD6A interacts with multiple proteins. One interaction partner is characterized by the presence of a PDZ domain and a Cdc42/Rac interactive binding... | |
medium_divergent_branch_05885 | Mast cell differentiation is enabled by more than one cell type. Evidence for one of these enabling cells describes a progenitor of the mast cell lineage with the following marker profile: FceRIa-low, CD117-positive, CD9-positive, T1/ST2-positive, SCA1-negative, and lineage-negative. Which cell does this specific proge... | basophil mast progenitor cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05885","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Mast cell differentiation is enabled by more than one cell type. Evidence for one of these enabling cells describes a progenitor of the mast cell lin... | |
medium_divergent_branch_05887 | HABP4 interacts with multiple proteins. One specific interaction partner was identified in a yeast two-hybrid system as a protein arginine methyltransferase. Which disease is associated with this specific interaction partner via a biomarker relationship? | Endometrial carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05887","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HABP4 interacts with multiple proteins. One specific interaction partner was identified in a yeast two-hybrid system as a protein arginine methyltran... | |
medium_divergent_branch_05888 | BECN1 interacts with multiple proteins. One of these interaction partners is described as the key de-ubiquitinase of Vimentin, and BECN1 has been shown to regulate this partner's mediated de-ubiquitination of Vimentin. Which protein, encoded by the gene corresponding to this specific interaction partner, is the subject... | Ubiquitin carboxyl-terminal hydrolase 14 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05888","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BECN1 interacts with multiple proteins. One of these interaction partners is described as the key de-ubiquitinase of Vimentin, and BECN1 has been sho... | |
medium_divergent_branch_05889 | HOOK2 interacts with multiple genes. One of these interacting partners is supported by evidence stating that 'Hook proteins were found to form homo- and heterodimers.' Which cell type is the gene corresponding to this specific interaction enriched in? | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05889","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HOOK2 interacts with multiple genes. One of these interacting partners is supported by evidence stating that 'Hook proteins were found to form homo- ... | |
medium_divergent_branch_05890 | NUB1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We showed that NUB1 physically interacts with a telomere-binding protein and promotes its degradation by the proteasome in the absence of NEDD8 conjugation.' Which protein, encoded by the gene connected to NUB1 via this specific i... | Telomeric repeat-binding factor 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05890","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NUB1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We showed that NUB1 physically interacts with a telomere-bi... | |
medium_divergent_branch_05891 | PSEN2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using the PS2 loop domain as the bait, the yeast two-hybrid system was used for screening, and mu-calpain was identified as a PS2 binding protein.' Which protein is encoded by the gene that interacts with PSEN2 in this specific c... | Calpain-1 catalytic subunit | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05891","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PSEN2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using the PS2 loop domain as the bait, the yeast two-hybri... | |
medium_divergent_branch_05892 | The gene ACVR1B interacts with multiple partners. One specific interaction is supported by evidence stating: 'Complexes between a truncated activin type IIA receptor and activin type IA and type IB receptors can be formed, as demonstrated by coimmunoprecipitation of these type I receptors with the truncated activin typ... | Activin receptor type-2A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05892","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ACVR1B interacts with multiple partners. One specific interaction is supported by evidence stating: 'Complexes between a truncated activin t... | |
medium_divergent_branch_05893 | BOP1 interacts with multiple proteins. One interaction is supported by evidence stating that mutant M1 and M5 proteins, associated with large pre-ribosomal complexes, co-immunoprecipitated Bop1 and the interacting partner, indicating their proper incorporation into the PeBoW-complex. Which protein is this interacting p... | Ribosome biogenesis protein WDR12 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05893","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BOP1 interacts with multiple proteins. One interaction is supported by evidence stating that mutant M1 and M5 proteins, associated with large pre-rib... | |
medium_divergent_branch_05894 | Fatty acid synthase (FASN) interacts with multiple proteins. One specific interaction is described by the evidence: 'Here we show that pVHL physically interacts with fatty acid synthase (FASN), displacing the E3 ubiquitin ligase complex.' Which protein, identified in this evidence, is connected to the gene encoding it ... | von Hippel-Lindau disease tumor suppressor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05894","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Fatty acid synthase (FASN) interacts with multiple proteins. One specific interaction is described by the evidence: 'Here we show that pVHL physicall... | |
medium_divergent_branch_05895 | Cardiac Purkinje fibers are anatomically classified under more than one parent term via the 'is a' relationship. One of these classifications is supported by evidence stating that the entity is part of the cardiac conduction system, receives signals from the bundle of His, and innervates ventricular cardiac muscle. Whi... | cardiac muscle tissue | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05895","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Cardiac Purkinje fibers are anatomically classified under more than one parent term via the 'is a' relationship. One of these classifications is supp... | |
medium_divergent_branch_05896 | GABARAPL2 interacts with multiple genes. One of these interactions is supported by evidence stating that the binding of a WD repeat-containing protein to GABARAP is indispensable for its recruitment to LC3B-positive structures and, thus, for the clearance of certain p62 structures by autophagy. Which disease is associa... | ventricular septal defect | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05896","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GABARAPL2 interacts with multiple genes. One of these interactions is supported by evidence stating that the binding of a WD repeat-containing protei... | |
medium_divergent_branch_05897 | FGF1 interacts with multiple genes. One interaction is supported by evidence stating: 'In solution, the extracellular domain of this receptor formed complexes with acidic FGF (FGF-1) and basic FGF (FGF-2), both in the presence and absence of heparin.' Which disease is associated with this receptor as a biomarker? | cholangiocarcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05897","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FGF1 interacts with multiple genes. One interaction is supported by evidence stating: 'In solution, the extracellular domain of this receptor formed ... | |
medium_divergent_branch_05898 | DLG4 interacts with multiple genes. One interaction is supported by evidence stating: 'Using yeast two hybrid and coimmunoprecipitation assays, we demonstrate that this N-terminal L27 domain of PSD-95beta, binds to an L27 domain in the membrane-associated guanylate kinase calcium/calmodulin-dependent serine kinase, and... | basophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05898","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DLG4 interacts with multiple genes. One interaction is supported by evidence stating: 'Using yeast two hybrid and coimmunoprecipitation assays, we de... | |
medium_divergent_branch_05899 | IRAK1 interacts with multiple proteins. One of these interaction partners is described as specifically binding two components of the IL-1-mediated signaling cascade: Toll-interacting protein (Tollip) and IL-1 receptor-associated kinase 1 (IRAK1). Which protein corresponds to this description? | Serine/threonine-protein kinase PINK1, mitochondrial | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05899","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IRAK1 interacts with multiple proteins. One of these interaction partners is described as specifically binding two components of the IL-1-mediated si... | |
medium_divergent_branch_05900 | The gene CKB interacts with multiple partners. One specific interaction was identified using a global yeast two-hybrid (Y2H) screen with monomeric B-CK as bait and a representative brain cDNA library, which repeatedly identified the cis-Golgi Matrix protein as a recurrent interacting partner of B-CK. Which disease is a... | developmental delay with hypotonia, myopathy, and brain abnormalities | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05900","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CKB interacts with multiple partners. One specific interaction was identified using a global yeast two-hybrid (Y2H) screen with monomeric B-... | |
medium_divergent_branch_05901 | The gene SYNRG interacts with multiple other genes. One specific interaction is supported by evidence stating: 'Yeast two-hybrid analysis showed that the AGEH domains of the GGA proteins as well as those of gamma-adaptins are able to interact with gamma-synergin, which was previously shown to localized in the TGN regio... | AP-1 complex subunit gamma-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05901","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SYNRG interacts with multiple other genes. One specific interaction is supported by evidence stating: 'Yeast two-hybrid analysis showed that... | |
medium_divergent_branch_05902 | MID1 interacts with multiple proteins. One of these interactions is characterized by the finding that circPDE4B facilitates the association between MID1 and the partner protein by acting as a scaffold to promote the partner's degradation through the proteasome. Which protein, connected to MID1 via this specific interac... | Chaperone Ric-8A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05902","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MID1 interacts with multiple proteins. One of these interactions is characterized by the finding that circPDE4B facilitates the association between M... | |
medium_divergent_branch_05903 | AKAP10 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Based on coprecipitation assays, the R binding domain interacts with the N-terminal dimerization domain of RIalpha and RIIalpha.' Identify the disease associated with the protein described in this evidence via a biomark... | neonatal severe primary hyperparathyroidism | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05903","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AKAP10 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Based on coprecipitation assays, the R binding d... | |
medium_divergent_branch_05904 | BTG1 is associated with multiple biological processes. One association is supported by evidence that BTG1-overexpressing endothelial cells displayed increased activity of the process in question. Which cell type is linked to this specific biological process via the 'enabled by cell' relationship? | mesenchymal cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05904","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BTG1 is associated with multiple biological processes. One association is supported by evidence that BTG1-overexpressing endothelial cells displayed ... | |
medium_divergent_branch_05905 | PTK2B interacts with multiple proteins. One interaction is supported by evidence describing 'Dimerization and subsequent phosphorylation on Tyr... the kinase PYK2'. Which protein corresponds to this specific interaction evidence? | Protein PEAK3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05905","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTK2B interacts with multiple proteins. One interaction is supported by evidence describing 'Dimerization and subsequent phosphorylation on Tyr... th... | |
medium_divergent_branch_05906 | TICAM1 interacts with multiple proteins. One specific interaction involving TICAM1 (also known as Trif) and a protein encoded by the gene connected to TICAM1 via this specific interaction evidence was confirmed using co-immunoprecipitation and GST-pull-down assays. Which protein, encoded by the gene connected to TICAM1... | Ubiquilin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05906","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TICAM1 interacts with multiple proteins. One specific interaction involving TICAM1 (also known as Trif) and a protein encoded by the gene connected t... | |
medium_divergent_branch_05907 | GADD45G interacts with multiple proteins. One interaction is supported by evidence stating: 'This study reports the cloning of a novel protein called [interacting partner] which interacts with Gadd45alpha, MyD118/Gadd45beta, and CR6/OIG37/Gadd45gamma.' Which biological process is the interacting partner mentioned in th... | mitochondrial translation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05907","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GADD45G interacts with multiple proteins. One interaction is supported by evidence stating: 'This study reports the cloning of a novel protein called... | |
medium_divergent_branch_05908 | MIR146A is associated with multiple biological processes. One association is supported by evidence stating: 'The overexpression of miR-146a-5p significantly induced VSMC proliferation and migration in vitro.' Identify the biological process that is positively regulated by the specific process linked to MIR146A via this... | vascular associated smooth muscle cell migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05908","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR146A is associated with multiple biological processes. One association is supported by evidence stating: 'The overexpression of miR-146a-5p signif... | |
medium_divergent_branch_05909 | PPP1CB interacts with multiple proteins. One interaction is supported by evidence describing a stable multimeric complex (the PTW/PP1 phosphatase complex) composed of the PP1 catalytic subunit, the regulatory subunit PNUTS, and two other regulatory subunits: Wdr82 and the protein in question. Which protein, encoded by ... | Nuclear inhibitor of protein phosphatase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05909","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PPP1CB interacts with multiple proteins. One interaction is supported by evidence describing a stable multimeric complex (the PTW/PP1 phosphatase com... | |
medium_divergent_branch_05910 | LILRA5 is involved in a biological process supported by evidence that cross-linking of this receptor on monocytes induces the production of pro-inflammatory cytokines, suggesting a role in inflammation. Which biological process is positively regulated by this specific process linked to LILRA5? | inflammatory response | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05910","source_qa_id":"medium_divergent_branch_06885","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"LILRA5 is involved in a biological process supported by evidence that cross-linking of this recep... | |
medium_divergent_branch_05911 | CBX7 interacts with multiple genes. One interaction is supported by evidence stating: 'On the basis of crystal structure and mutational analysis of this domain we show that the conserved surface is responsible for interaction with Cbx members of the PRC1 and homodimer formation.' Which disease is associated with the ge... | Luo-Schoch-Yamamoto syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05911","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CBX7 interacts with multiple genes. One interaction is supported by evidence stating: 'On the basis of crystal structure and mutational analysis of t... | |
medium_divergent_branch_05912 | FAM76B is associated with multiple biological processes. One association is supported by evidence that FAM76B was first demonstrated to inhibit the NF-κB-mediated inflammatory pathway by affecting the translocation of hnRNPA2B1 in vitro. Which biological process, connected to the process supported by this evidence, is ... | inflammatory response | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05912","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FAM76B is associated with multiple biological processes. One association is supported by evidence that FAM76B was first demonstrated to inhibit the N... | |
medium_divergent_branch_05913 | STX2 interacts with multiple genes. One interaction is supported by evidence stating: 'In a yeast two-hybrid assay, syntaxins 2, 3 and 4 interacted with SNAP-23 and VAMP-3.' Which disease is associated with the gene identified in this evidence via a biomarker relationship? | atherosclerosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05913","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STX2 interacts with multiple genes. One interaction is supported by evidence stating: 'In a yeast two-hybrid assay, syntaxins 2, 3 and 4 interacted w... | |
medium_divergent_branch_05914 | The gene PTPRN interacts with multiple partners. One interaction is supported by evidence stating: 'Six new interacting proteins were identified by this approach: mitogen-activated protein kinase-activating death domain, the isoform [REDACTED], PTPrho, PTPsigma, sorting nexin 19 (SNX19) and cyclophilin A.' Which protei... | MAP kinase-activating death domain protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05914","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PTPRN interacts with multiple partners. One interaction is supported by evidence stating: 'Six new interacting proteins were identified by t... | |
medium_divergent_branch_05915 | SND1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Finally, p100 associated with the large subunit of RNA polymerase II and was mediating interaction between STAT6 and RNA polymerase II.' Which protein, connected to SND1 via this interaction, is encoded by the gene in question? | DNA-directed RNA polymerase II subunit RPB1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05915","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SND1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Finally, p100 associated with the large subunit of RNA poly... | |
medium_divergent_branch_05916 | WWP1 interacts with multiple proteins. One specific interaction is characterized by the engagement of the first and third WW domains of WWP1 with the PY motif of the interacting partner. Which protein corresponds to this specific interaction partner? | RING finger protein 11 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05916","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WWP1 interacts with multiple proteins. One specific interaction is characterized by the engagement of the first and third WW domains of WWP1 with the... | |
medium_divergent_branch_05917 | PSMA6 interacts with multiple proteins. One interaction is supported by evidence stating: 'In the present study, we demonstrate that the 20S proteasome subunits alpha4 and alpha7 interact with each other as well as all the alpha-subunits in vivo and in vitro.' Which protein, connected to PSMA6 via this interaction, enc... | Proteasome subunit alpha type-7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05917","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PSMA6 interacts with multiple proteins. One interaction is supported by evidence stating: 'In the present study, we demonstrate that the 20S proteaso... | |
medium_divergent_branch_05918 | TBK1 interacts with multiple proteins. One interaction partner is described in evidence stating that TBK1 is associated with the N-terminal region of a specific adapter protein. Which protein, connected to TBK1 via this interaction, is encoded by the gene in question? | TIR domain-containing adapter molecule 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05918","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TBK1 interacts with multiple proteins. One interaction partner is described in evidence stating that TBK1 is associated with the N-terminal region of... | |
medium_divergent_branch_05919 | NET1 interacts with multiple proteins. One interaction is supported by evidence stating: 'This paper reports the identification of a Rho family nucleotide exchange factor termed mNET1 as a candidate-interacting partner for the first PDZ domain of a membrane-associated guanylate kinase with inverted arrangement of prote... | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05919","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NET1 interacts with multiple proteins. One interaction is supported by evidence stating: 'This paper reports the identification of a Rho family nucle... | |
medium_divergent_branch_05920 | hsa-miR-148a-3p regulates more than one cell type. One line of evidence states: 'When prematurely expressed, miR-148a promotes the differentiation and survival of plasmablasts and reduces frequencies of IgG1(+) cells in primary B-cell cultures.' Which cell type, connected to hsa-miR-148a-3p via a 'regulates' relationsh... | plasmablast | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05920","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"hsa-miR-148a-3p regulates more than one cell type. One line of evidence states: 'When prematurely expressed, miR-148a promotes the differentiation an... | |
medium_divergent_branch_05921 | EBF1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Mass spectrometry analysis and in vitro kinase testing revealed that the interaction partner phosphorylates EBF1 on Y256, reducing the stability and expression of EBF1.' Which cellular component is the gene involved in this ... | phosphorylase kinase complex | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05921","source_qa_id":"medium_divergent_branch_02310","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"EBF1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'M... | |
medium_divergent_branch_05922 | PLCG1 interacts with multiple proteins. One specific interaction involves the PLCgamma1-SH3 domain binding to the human Ras guanine nucleotide exchange factor son-of-sevenless-2 via a proline-rich domain. Which disease is associated with this specific interacting partner through genomic alterations? | Noonan syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05922","source_qa_id":"medium_divergent_branch_06531","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PLCG1 interacts with multiple proteins. One specific interaction involves the PLCgamma1-SH3 domai... | |
medium_divergent_branch_05923 | SKP1 interacts with multiple proteins. One specific interaction partner is an F-box protein that, together with SKP1 and Cullin-1, forms the SCF complex to function as an E3 ubiquitin ligase. Which protein is encoded by the gene corresponding to this specific interaction partner? | S-phase kinase-associated protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05923","source_qa_id":"medium_divergent_branch_01495","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"SKP1 interacts with multiple proteins. One specific interaction partner is an F-box protein that,... | |
medium_divergent_branch_05924 | CD46 is involved in multiple biological processes. One such process is characterized by evidence stating that CD46 functions as a pathogen receptor and acts as a potent costimulator for the induction of interferon-γ (IFN-γ)-secreting effector T helper type 1 (T(H)1) cells, facilitating their subsequent switch into inte... | interleukin-10 production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05924","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD46 is involved in multiple biological processes. One such process is characterized by evidence stating that CD46 functions as a pathogen receptor a... | |
medium_divergent_branch_05925 | FBXO3 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we show that FBXO3, the substrate receptor of an SCF ubiquitin ligase complex, binds and ubiquitylates a specific protein, thereby targeting it for proteasomal degradation.' Which protein, encoded by the gene connec... | Cilia- and flagella-associated protein 410 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05925","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBXO3 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we show that FBXO3, the substrate receptor o... | |
medium_divergent_branch_05928 | BAZ2A interacts with multiple genes. One of these interaction partners is noted in evidence stating: 'However, interaction with TIP5, a subunit of the nucleolar chromatin remodeling complex, NoRC, recovers DNA-binding activity.' Which cellular component is the gene associated with this specific evidence located in? | nucleus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05928","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BAZ2A interacts with multiple genes. One of these interaction partners is noted in evidence stating: 'However, interaction with TIP5, a subunit of th... | |
medium_divergent_branch_05929 | MED15 interacts with multiple proteins. One specific interaction involves a protein whose phosphorylated form binds to MED15, acting as a transcriptional coactivator that activates proarrest, proapoptotic, and anti-metastatic genes. Which protein is encoded by the gene corresponding to this interacting partner? | Tumor protein p73 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05929","source_qa_id":"medium_divergent_branch_01465","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MED15 interacts with multiple proteins. One specific interaction involves a protein whose phospho... | |
medium_divergent_branch_05930 | The protein Norrin (NDP) interacts with multiple partners. One specific interaction is supported by evidence demonstrating that Norrin and Fz4 function as a ligand-receptor pair, citing the specificity and high affinity of their binding, the induction of Fz4- and Lrp-dependent Wnt pathway activation, and the vascular p... | Frizzled-4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05930","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein Norrin (NDP) interacts with multiple partners. One specific interaction is supported by evidence demonstrating that Norrin and Fz4 functi... | |
medium_divergent_branch_05931 | RNF2 interacts with multiple genes. Evidence for one of these interactions states: 'Here, we identified the E3 ubiquitin-protein ligases RNF2 and Bmi1 to associate with this protein with subsequent poly-ubiquitination at either position 48 or 63 of ubiquitin.' Which cell type is the gene identified by this evidence enr... | regulatory T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05931","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF2 interacts with multiple genes. Evidence for one of these interactions states: 'Here, we identified the E3 ubiquitin-protein ligases RNF2 and Bmi... | |
medium_divergent_branch_05932 | MUL1 interacts with multiple proteins. One of these interaction partners has been shown to partially translocate to mitochondria following selenite treatment and to interact with MUL1. Which protein is encoded by the gene corresponding to this specific interaction partner? | Serine/threonine-protein kinase ULK1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05932","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MUL1 interacts with multiple proteins. One of these interaction partners has been shown to partially translocate to mitochondria following selenite t... | |
medium_divergent_branch_05933 | LRP1 interacts with multiple proteins. One specific interaction was identified using both a conventional screen and a split-ubiquitin screen, which revealed a novel interactor. Which protein is encoded by the gene corresponding to this interactor? | PTB-containing, cubilin and LRP1-interacting protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05933","source_qa_id":"medium_divergent_branch_01780","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"LRP1 interacts with multiple proteins. One specific interaction was identified using both a conve... | |
medium_divergent_branch_05934 | The gene PDGFB is enriched in multiple cell types. One specific cell type shows a mean expression of 9.69 TPM, a z-score of 1.98, and a fold enrichment of 6.29. Which cell type is this, and what is its direct parent category in the cell type hierarchy (i.e., what is it a subtype of)? | mature alpha-beta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05934","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PDGFB is enriched in multiple cell types. One specific cell type shows a mean expression of 9.69 TPM, a z-score of 1.98, and a fold enrichme... | |
medium_divergent_branch_05935 | NUDC interacts with multiple genes. One of these interaction partners is described in a study stating: 'To explore the underlying mechanism, we found that the p23 domain-containing protein NudC bound to the molecular chaperone [Gene], which is also associated with LIS1.' Which cell type is the gene identified by this d... | natural killer cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05935","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NUDC interacts with multiple genes. One of these interaction partners is described in a study stating: 'To explore the underlying mechanism, we found... | |
medium_divergent_branch_05936 | DIDO1 interacts with multiple genes. One interaction is supported by evidence stating: 'Binding of the Dido3 amino terminus to histones and to the polymerase jaw domain was previously reported, and here we show interaction between its carboxy terminus and this protein.' Which disease is associated with this interaction... | kidney neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05936","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DIDO1 interacts with multiple genes. One interaction is supported by evidence stating: 'Binding of the Dido3 amino terminus to histones and to the po... | |
medium_divergent_branch_05937 | BCL2L1 interacts with multiple genes. One specific interaction is supported by evidence showing that a protein encoded by a gene interacting with Bcl-xL both in vivo and in vitro, with binding sites mapped to the N-terminal region of this protein and the Bcl-2 homology domain 3 of Bcl-xL. Which disease is associated wi... | Lyme disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05937","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BCL2L1 interacts with multiple genes. One specific interaction is supported by evidence showing that a protein encoded by a gene interacting with Bcl... | |
medium_divergent_branch_05938 | GNAI1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We provide here structural evidence that the protein product of the ocular albinism type 1 gene, a pigment cell-specific integral membrane glycoprotein, represents a novel member of the GPCR superfamily and demonstrate that it bi... | G-protein coupled receptor 143 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05938","source_qa_id":"medium_divergent_branch_00127","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"GNAI1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We pro... | |
medium_divergent_branch_05940 | MAVS interacts with multiple proteins. One interaction partner is described in the following context: 'Upon the recognition of viral RNA, the Lys-172 residue of this partner undergoes ubiquitination induced by tripartite motif protein 25 (TRIM25), an essential protein for antiviral signal transduction.' Which protein i... | Antiviral innate immune response receptor RIG-I | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05940","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAVS interacts with multiple proteins. One interaction partner is described in the following context: 'Upon the recognition of viral RNA, the Lys-172... | |
medium_divergent_branch_05941 | The gene SPTBN1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Mice deficient in neuronal βII-spectrin have defects in cortical organization, developmental delay and behavioral deficiencies.' Identify the biological process described by this evidence, and t... | anatomical structure formation involved in morphogenesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05941","source_qa_id":"medium_divergent_branch_02747","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene SPTBN1 is associated with multiple biological processes. One specific association is sup... | |
medium_divergent_branch_05943 | DCUN1D4 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that DCNLs form stable stoichiometric complexes with this protein and cullins that can only be neddylated in the presence of a substrate adaptor.' Which protein, connected to DCUN1D4 via this interaction, is encoded by... | Cullin-associated NEDD8-dissociated protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05943","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DCUN1D4 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that DCNLs form stable stoichiometric complexes... | |
medium_divergent_branch_05944 | Rift Valley fever phlebovirus downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.005 and an adjusted p-value of 0.0435. For which disease is that selected gene recorded as a biomarker? | mammary neoplasms, animal | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05944","source_qa_id":"medium_divergent_branch_03125","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Rift Valley fever phlebovirus downregulates several genes. In the recorded experiment, one bra... | |
medium_divergent_branch_05945 | MIR346 is associated with multiple biological processes. One specific association is supported by the finding that 'miR-346 positively regulates hBMSC osteogenic differentiation by targeting GSK-3β and activating the Wnt/β-catenin pathway.' Which biological process is a parent term (via an 'is a' relationship) of the p... | stem cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05945","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR346 is associated with multiple biological processes. One specific association is supported by the finding that 'miR-346 positively regulates hBMS... | |
medium_divergent_branch_05947 | Entacapone interacts with multiple substances. One specific interaction is characterized by the mechanism where Entacapone complexes with and depletes the interacting substance, leading to changes in gut microbiome composition and function. Which disease is the interacting substance indicated for? | iron deficiency anemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05947","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Entacapone interacts with multiple substances. One specific interaction is characterized by the mechanism where Entacapone complexes with and deplete... | |
medium_divergent_branch_05948 | FANCF interacts with multiple proteins. One specific interaction is described as a direct protein-protein interaction between the FA core complex and hairy enhancer of split 1, linking FA proteins to the Notch1 developmental pathway. Which disease is associated with this specific interacting partner? | melanoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05948","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FANCF interacts with multiple proteins. One specific interaction is described as a direct protein-protein interaction between the FA core complex and... | |
medium_divergent_branch_05949 | Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -2.332 and an adjusted p-value of 0.0459. Which disease has a genomic-alteration link with that selected gene? | skin carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05949","source_qa_id":"medium_divergent_branch_01498","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human mastadenovirus C downregulates several genes. In the recorded experiment, one branch sho... | |
medium_divergent_branch_05950 | MET interacts with multiple proteins. One specific interaction is characterized by the statement: 'Mechanistically, the interaction partner interacted with MET via the Src homology 2 domain and this interaction was promoted by MET tyrosine kinase activity.' Which protein, connected to MET through this specific interact... | Suppressor of cytokine signaling 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05950","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MET interacts with multiple proteins. One specific interaction is characterized by the statement: 'Mechanistically, the interaction partner interacte... | |
medium_divergent_branch_05952 | Desmoplakin (DSP) interacts with multiple proteins. One interaction is supported by evidence stating: 'Our results confirm the ability of the DP COOH terminus (DPCT) to interact with at least two regions of the head domain of the type II epidermal keratin K1.' Identify the disease associated with the gene involved in t... | lymphocytic choriomeningitis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05952","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Desmoplakin (DSP) interacts with multiple proteins. One interaction is supported by evidence stating: 'Our results confirm the ability of the DP COOH... | |
medium_divergent_branch_05953 | DDIT3 interacts with multiple genes. One of these interacting partners recognizes a Ser/Thr-rich degron in the transactivation domain of DDIT3 and triggers its degradation via the ubiquitin-proteasome pathway. Which disease is associated with this specific interacting gene as a biomarker? | clear cell renal carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05953","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DDIT3 interacts with multiple genes. One of these interacting partners recognizes a Ser/Thr-rich degron in the transactivation domain of DDIT3 and tr... | |
medium_divergent_branch_05954 | PHLPP1 interacts with multiple proteins. One of these interactions is supported by evidence from co-immunoprecipitation and ubiquitination assays, which demonstrated that the interacting partner promotes the ubiquitination of PHLPP1 in chordoma cells. Which protein, among those interacting with PHLPP1, is described by ... | E3 ubiquitin-protein ligase TRIM11 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05954","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PHLPP1 interacts with multiple proteins. One of these interactions is supported by evidence from co-immunoprecipitation and ubiquitination assays, wh... | |
medium_divergent_branch_05955 | ABCA12 is associated with multiple biological processes. One association is supported by evidence stating: 'We concluded that ABCA12 works as an epidermal keratinocyte lipid transporter and that defective ABCA12 results in a loss of the skin lipid barrier, leading to Harlequin Ichthyosis.' Which biological process, con... | lipid localization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05955","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ABCA12 is associated with multiple biological processes. One association is supported by evidence stating: 'We concluded that ABCA12 works as an epid... | |
medium_divergent_branch_05956 | The gene DBNL is known to interact with multiple proteins. One specific interaction involves a critical protein-tyrosine kinase in TCR signaling, where the interaction was induced by TCR signaling. Which protein is encoded by the gene corresponding to this interacting partner? | Tyrosine-protein kinase ZAP-70 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05956","source_qa_id":"medium_divergent_branch_02212","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene DBNL is known to interact with multiple proteins. One specific interaction involves a cr... | |
medium_divergent_branch_05957 | RASSF1 interacts with multiple proteins. Experimental evidence indicates that seventy percent of interacting clones showed homology to microtubule-associated proteins, specifically mentioning the target protein and VCY2IP1/C19ORF5. Which protein is encoded by the gene that interacts with RASSF1 and fits this descriptio... | Microtubule-associated protein 1B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05957","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RASSF1 interacts with multiple proteins. Experimental evidence indicates that seventy percent of interacting clones showed homology to microtubule-as... | |
medium_divergent_branch_05958 | POF1B is associated with multiple biological processes. One association is supported by evidence stating: 'However, tight junction assembly was altered, cells were dysmorphic and the monolayer organisation was also altered in three-dimensional culture systems.' Which biological process, connected to the process support... | apical junction assembly | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05958","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"POF1B is associated with multiple biological processes. One association is supported by evidence stating: 'However, tight junction assembly was alter... | |
medium_divergent_branch_05960 | CAND1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that DCNLs form stable stoichiometric complexes with CAND1 and cullins that can only be neddylated in the presence of a substrate adaptor.' Which protein, connected to CAND1 via this specific interaction evidence, is enc... | DCN1-like protein 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05960","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CAND1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We found that DCNLs form stable stoichiometric complexes w... | |
medium_divergent_branch_05962 | MGRN1 interacts with multiple proteins. One specific interaction is characterized by the finding that Mahogunin binds to the ubiquitin E2 variant (UEV) domain of the target protein via its PSAP motif and catalyzes its monoubiquitylation both in vivo and in vitro. Which protein, encoded by the gene connected to MGRN1 th... | Tumor susceptibility gene 101 protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05962","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MGRN1 interacts with multiple proteins. One specific interaction is characterized by the finding that Mahogunin binds to the ubiquitin E2 variant (UE... | |
medium_divergent_branch_05963 | MAPK9 interacts with multiple proteins. One interaction is supported by evidence stating: 'The JNK2-mediated phosphorylation of a scaffold protein results in the dissociation of Akt1 from this scaffold protein and subsequently restores Akt1 enzyme activity.' Which protein, encoded by the gene involved in this specific ... | C-Jun-amino-terminal kinase-interacting protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05963","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAPK9 interacts with multiple proteins. One interaction is supported by evidence stating: 'The JNK2-mediated phosphorylation of a scaffold protein re... | |
medium_divergent_branch_05965 | IPO7 interacts with multiple genes. One of these interacting partners is described by the following evidence: 'Instead, it formed stable complexes with several importins (-β, -7, -β/7, -13, and transportin 1) and was also imported into the nucleus in digitonin-permeabilized cells by these factors.' Which disease is ass... | alcoholic liver cirrhosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05965","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IPO7 interacts with multiple genes. One of these interacting partners is described by the following evidence: 'Instead, it formed stable complexes wi... | |
medium_divergent_branch_05966 | ENTR1 is reported to interact with multiple proteins. One specific interaction partner was identified in a study where primary interactions were confirmed by coimmunoprecipitation and/or bioluminescence resonance energy transfer (BRET) experiments for a set of 11 proteins, including ANKHD1, CHMP5, SDCCAG3, TRIM41, LDOC... | Nucleotide-binding oligomerization domain-containing protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05966","source_qa_id":"medium_divergent_branch_07052","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ENTR1 is reported to interact with multiple proteins. One specific interaction partner was identi... | |
medium_divergent_branch_05967 | FOS interacts with multiple genes. One of these interacting partners targets c-Fos for polyubiquitylation and regulates c-Fos protein levels. Which disease is associated with this specific interacting gene? | neurodevelopmental disorder with congenital cardiac defects and variable renal and ocular abnormalities | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05967","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOS interacts with multiple genes. One of these interacting partners targets c-Fos for polyubiquitylation and regulates c-Fos protein levels. Which d... | |
medium_divergent_branch_05968 | The gene SOD2 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Furthermore, stimulation of mitochondrial O(2)(-) production induced an increase of Mn-SOD expression.' Identify the biological process linked to SOD2 by this evidence, and then determine the pare... | response to oxygen radical | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05968","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene SOD2 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Furthermore, stimulation ... | |
medium_divergent_branch_05969 | The gene NR0B1 (DAX-1) interacts with multiple partners. One interaction is supported by evidence stating that 'RIP 140 was also shown to interact with DAX-1.' Which protein is encoded by the gene that interacts with NR0B1 in this specific context? | Nuclear receptor-interacting protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05969","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NR0B1 (DAX-1) interacts with multiple partners. One interaction is supported by evidence stating that 'RIP 140 was also shown to interact wi... | |
medium_divergent_branch_05970 | LCK interacts with multiple genes. One specific interaction is supported by evidence stating: 'Immunoprecipitation of this gene from Jurkat cells confirmed the association with LCK in vivo, and upon PMA stimulation, the phosphorylation level of this gene increased.' Which disease is connected to this specific interacti... | colon carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05970","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LCK interacts with multiple genes. One specific interaction is supported by evidence stating: 'Immunoprecipitation of this gene from Jurkat cells con... | |
medium_divergent_branch_05971 | MAP3K7 interacts with multiple genes. One interaction is supported by evidence stating that VRK2, a member of a novel Ser-Thr kinase family, stably interacts with a scaffold protein, TAK1, and MKK7, but not JNK, and can be isolated in oligomeric complexes containing TAK1, MKK7beta1, and JNK. Which gene, connected to MA... | RELN | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05971","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP3K7 interacts with multiple genes. One interaction is supported by evidence stating that VRK2, a member of a novel Ser-Thr kinase family, stably i... | |
medium_divergent_branch_05973 | DNAH5 is associated with multiple biological processes. One specific process is supported by evidence showing that in patients with Primary Ciliary Dyskinesia (PCD) carrying DNAH5 or DNAI1 mutations, the protein is absent from the respiratory ciliary axoneme and instead accumulates at microtubule-organizing centers. Wh... | outer dynein arm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05973","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DNAH5 is associated with multiple biological processes. One specific process is supported by evidence showing that in patients with Primary Ciliary D... | |
medium_divergent_branch_05974 | JAK2 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: 'Here we show that human JAK2 is present in the nucleus of haematopoietic cells and directly phosphorylates Tyr 41 (Y41) on histone H3.' Which cellular component, connected ... | chromosome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05974","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"JAK2 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: 'H... | |
medium_divergent_branch_05975 | CIB1 interacts with multiple genes. One interaction is supported by evidence stating: 'First, complexes between KIP and the catalytic subunit of telomerase (hTERT) were identified using the yeast two-hybrid technique.' Which protein is encoded by the gene connected to CIB1 through this specific interaction? | Telomerase reverse transcriptase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05975","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CIB1 interacts with multiple genes. One interaction is supported by evidence stating: 'First, complexes between KIP and the catalytic subunit of telo... | |
medium_divergent_branch_05976 | CLCN3 interacts with multiple proteins. One interaction partner is supported by evidence stating that ClC-3B, along with CFTR, binds to EBP50 (ERM-binding phosphoprotein 50) and this specific partner, all of which are concentrated at the plasma membrane. Which protein is encoded by the gene corresponding to this intera... | Na(+)/H(+) exchange regulatory cofactor NHE-RF3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05976","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CLCN3 interacts with multiple proteins. One interaction partner is supported by evidence stating that ClC-3B, along with CFTR, binds to EBP50 (ERM-bi... | |
medium_divergent_branch_05977 | The immune response in nasopharyngeal-associated lymphoid tissue is enabled by more than one cell type. Evidence for one of these connections describes a gut-associated lymphoid tissue macrophage found in tonsils. Which anatomical structure is the selected cell type part of? | tonsil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05977","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The immune response in nasopharyngeal-associated lymphoid tissue is enabled by more than one cell type. Evidence for one of these connections describ... | |
medium_divergent_branch_05978 | ATP1B3 interacts with multiple genes. One interaction is supported by evidence stating: 'To investigate CASPR1's physiological role in BMECs, here we used CASPR1 as a bait in a yeast two-hybrid screen to identify CASPR1-interacting proteins and identified the β3 subunit of Na.' Which protein is encoded by the gene that... | Contactin-associated protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05978","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATP1B3 interacts with multiple genes. One interaction is supported by evidence stating: 'To investigate CASPR1's physiological role in BMECs, here we... | |
medium_divergent_branch_05979 | NCK1 interacts with multiple proteins. One interaction partner is described as binding to the first and third SH3 domains of Nck in vitro and colocalizing with Nck at sarcomere Z-discs within cardiac myocytes. Which protein is encoded by the gene corresponding to this specific interaction partner? | NCK-interacting protein with SH3 domain | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05979","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NCK1 interacts with multiple proteins. One interaction partner is described as binding to the first and third SH3 domains of Nck in vitro and colocal... | |
medium_divergent_branch_05980 | The gene TNFRSF1A interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we report the isolation of a novel protein, sentrin, which interacts with Fas/APO-1 and TNF receptor 1 but not with FADD/MORT1 or CD40.' Which protein, encoded by the gene connected to TNFRSF1A via this ... | Small ubiquitin-related modifier 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05980","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TNFRSF1A interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we report the isolation of a nov... | |
medium_divergent_branch_05981 | The innate immune response is enabled by multiple cell types. One such cell type is described as a transcriptomically distinct central nervous system macrophage found in the parenchyma of the central nervous system, with markers including CD11b-positive, F4/80-positive, and CD68-positive. Which cell type is connected t... | mesodermal cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05981","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The innate immune response is enabled by multiple cell types. One such cell type is described as a transcriptomically distinct central nervous system... | |
medium_divergent_branch_05982 | DDX20 is known to bind to multiple protein partners. One specific interaction partner is supported by evidence stating that Gemin3 interacts directly with SMN, as well as with SmB, SmD2, and SmD3. Which protein is encoded by the gene corresponding to this specific DDX20 binding partner? | Small nuclear ribonucleoprotein Sm D1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05982","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DDX20 is known to bind to multiple protein partners. One specific interaction partner is supported by evidence stating that Gemin3 interacts directly... | |
medium_divergent_branch_05983 | HES1 is known to bind to multiple proteins. One of these binding partners is described in the literature as interacting and being co-expressed with mammalian HES proteins in both neural and non-neural tissues. Which protein product is encoded by the gene corresponding to this specific binding partner? | Transducin-like enhancer protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05983","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HES1 is known to bind to multiple proteins. One of these binding partners is described in the literature as interacting and being co-expressed with m... | |
medium_divergent_branch_05984 | PHF1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we report that histone H3 lysine 36 trimethylation (H3K36me3) binding activity is harbored in the Tudor motifs of PRC2-associated polycomb-like (PCL) proteins PHF1/PCL1 and PHF19/PCL3.' Which protein, connected to PHF1 via an... | Histone H3.1t | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05984","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PHF1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we report that histone H3 lysine 36 trimethylation (H3... | |
medium_divergent_branch_05985 | PMEPA1 interacts with multiple proteins. One interaction partner is supported by evidence stating: 'In addition, TMEPAI interacts with the dynactin pointed-end complex subunits dynactin 5 and dynactin 6.' Which protein, encoded by the gene connected to PMEPA1 via this specific interaction, is the subject of this eviden... | Dynactin subunit 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05985","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PMEPA1 interacts with multiple proteins. One interaction partner is supported by evidence stating: 'In addition, TMEPAI interacts with the dynactin p... | |
medium_divergent_branch_05986 | SMURF1 interacts with multiple genes. One of these interaction partners contains a phosphotyrosine binding (PTB) domain that binds the ubiquitin ligase SMURF1. Which cell type is enriched for this specific interaction partner? | regulatory T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05986","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMURF1 interacts with multiple genes. One of these interaction partners contains a phosphotyrosine binding (PTB) domain that binds the ubiquitin liga... | |
medium_divergent_branch_05987 | GNB5 interacts with multiple G-protein gamma subunits. One specific interaction is supported by evidence stating: 'Interestingly, although untagged Ggamma3 did not interact with Gbeta5, CFP-tagged Ggamma3 strongly interacted with YFP-tagged Gbeta5 in FRET studies.' Which protein is encoded by the gene corresponding to ... | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05987","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GNB5 interacts with multiple G-protein gamma subunits. One specific interaction is supported by evidence stating: 'Interestingly, although untagged G... | |
medium_divergent_branch_05989 | The gene CTNNAL1 is enriched in multiple immune cell types. One specific cell type shows a mean expression of 5.72 TPM, a z-score of 2.28, and a fold enrichment of 5.93. Which broader cell category is this specific cell type a subtype of? | mature T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05989","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CTNNAL1 is enriched in multiple immune cell types. One specific cell type shows a mean expression of 5.72 TPM, a z-score of 2.28, and a fold... | |
medium_divergent_branch_05990 | ITGB5 interacts with multiple proteins. One interaction is supported by evidence stating: 'We find that VEGF-stimulated Src activity in chick embryo blood vessels induces the coupling of focal adhesion kinase to integrin alpha(v)beta5, a critical event in VEGF-mediated signaling and biological responsiveness.' Which pr... | Focal adhesion kinase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05990","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ITGB5 interacts with multiple proteins. One interaction is supported by evidence stating: 'We find that VEGF-stimulated Src activity in chick embryo ... | |
medium_divergent_branch_05991 | The gene IL12B is associated with multiple biological processes. One specific association is supported by evidence stating: 'In contrast, IL-12 mediated specific inhibition of IL-17 production.' Identify the biological process linked to this specific association that acts to negatively regulate a downstream target. | interleukin-17 production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05991","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene IL12B is associated with multiple biological processes. One specific association is supported by evidence stating: 'In contrast, IL-12 media... | |
medium_divergent_branch_05992 | TRIM22 interacts with multiple proteins. Evidence for one of these interactions indicates that domain mapping revealed the SPRY domain mediates interactions with the target protein and FIP200, while the N-terminal region interacts with ULK1 and ATG101. Which protein is encoded by the gene corresponding to this interact... | Autophagy-related protein 13 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05992","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM22 interacts with multiple proteins. Evidence for one of these interactions indicates that domain mapping revealed the SPRY domain mediates inter... |
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