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medium_divergent_branch_05994 | The biological process 'positive regulation of iron ion transmembrane transport' is a subtype of two distinct parent processes. One of these parent processes is defined by the evidence: 'Any process that activates or increases the frequency, rate or extent of the directed movement of iron ions from one side of a membra... | monoatomic cation transmembrane transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05994","source_qa_id":"medium_divergent_branch_03473","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'positive regulation of iron ion transmembrane transport' is a subtype of ... | |
medium_divergent_branch_05995 | ULK1 interacts with multiple genes. One of these interaction partners is described in the following context: 'To examine the mechanism of Unc51.1 regulation of axon extension, we have identified two direct binding partners. The first, a negative regulator of Ras, is expressed within axons and growth cones of developing... | intellectual disability, autosomal dominant 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05995","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ULK1 interacts with multiple genes. One of these interaction partners is described in the following context: 'To examine the mechanism of Unc51.1 reg... | |
medium_divergent_branch_05996 | CDT1 interacts with multiple genes. One interaction is supported by evidence stating: 'This poly-ubiquitination of Geminin prevents DNA replication over-firing by indirectly blocking the association of Cdt1 with the MCM protein complex, an interaction required for DNA unwinding and replication.' Which disease is associ... | autosomal dominant nonsyndromic hearing loss 70 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05996","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CDT1 interacts with multiple genes. One interaction is supported by evidence stating: 'This poly-ubiquitination of Geminin prevents DNA replication o... | |
medium_divergent_branch_05997 | The gene HSF2 is enriched in multiple cell types. One specific cell type shows a mean expression of 24.93 TPM, a z-score of 1.80, and a fold enrichment of 3.27. Which cell type does this specific cell develop from? | mature CD4 single-positive thymocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05997","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene HSF2 is enriched in multiple cell types. One specific cell type shows a mean expression of 24.93 TPM, a z-score of 1.80, and a fold enrichme... | |
medium_divergent_branch_05998 | MARCH6 interacts with multiple genes. One interaction is supported by evidence stating: 'In a setting of transient coexpression in HEK-293 cells, TEB4 and D2 could be coimmunoprecipitated, and additional TEB4 expression decreased D2 activity by approximately 50% (P < 0.05).' Which protein is encoded by the gene connect... | Type II iodothyronine deiodinase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05998","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MARCH6 interacts with multiple genes. One interaction is supported by evidence stating: 'In a setting of transient coexpression in HEK-293 cells, TEB... | |
medium_divergent_branch_05999 | Desmoglein-3 (DSG3) interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We found that this protein binds all three desmogleins, desmocollin (Dsc) 3a and -3b, and possibly also Dsc1a and -2a.' Which protein is encoded by the gene corresponding to this interaction partner? | Plakophilin-3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_05999","source_qa_id":"medium_divergent_branch_03199","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"Desmoglein-3 (DSG3) interacts with multiple proteins. One specific interaction is supported by ev... | |
medium_divergent_branch_06000 | SMURF2 interacts with multiple proteins. One specific interaction partner binds to the SMURF2 complex, deubiquitinates and stabilizes the type I TGF-β receptor (TβR-I), and thereby enhances TGF-β signaling. Which disease is associated with this specific interaction partner as a biomarker? | Moyamoya disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06000","source_qa_id":"medium_divergent_branch_02488","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"SMURF2 interacts with multiple proteins. One specific interaction partner binds to the SMURF2 com... | |
medium_divergent_branch_06001 | GLI1 interacts with multiple proteins. One specific interaction partner was validated by reciprocal pulldowns using epitope-tagged proteins in HEK293T cells, as well as by co-immunoprecipitation of endogenous proteins in a medulloblastoma cell line. Which protein is this interaction partner? | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06001","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GLI1 interacts with multiple proteins. One specific interaction partner was validated by reciprocal pulldowns using epitope-tagged proteins in HEK293... | |
medium_divergent_branch_06002 | AAMP is associated with multiple biological processes. One association is supported by evidence stating: 'These data reveal an important functional role of AAMP in the migration of SMCs, identifying AAMP as a potential target to limit lesion formation after injury.' Which biological process is a parent term (via 'is a'... | muscle cell migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06002","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AAMP is associated with multiple biological processes. One association is supported by evidence stating: 'These data reveal an important functional r... | |
medium_divergent_branch_06003 | PLCB3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using its second PDZ domain, NHERF2 was found to indirectly link LPA(2) to PLC-beta3 to form a complex, and the other PLC-beta isozymes were not included in the protein complex.' Which protein, connected to PLCB3 via this specifi... | Lysophosphatidic acid receptor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06003","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PLCB3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using its second PDZ domain, NHERF2 was found to indirectl... | |
medium_divergent_branch_06004 | ARHGAP1 interacts with multiple genes. One interaction is supported by evidence stating: 'Using glutathione S-transferase recombinant proteins, immunoprecipitation studies, and yeast two-hybrid assays, it was found that a specific interaction partner and Cdc42GAP could form homo and hetero complexes via their conserved... | RAB11A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06004","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ARHGAP1 interacts with multiple genes. One interaction is supported by evidence stating: 'Using glutathione S-transferase recombinant proteins, immun... | |
medium_divergent_branch_06005 | SRF interacts with multiple proteins. One interaction is supported by evidence stating: 'By using different biochemical assays such as affinity precipitation of protein, GST-pulldown assay, and coimmunoprecipitation of proteins, we show that SRF binds to the protein encoded by the gene connected to SRF via this specifi... | Transcriptional enhancer factor TEF-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06005","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SRF interacts with multiple proteins. One interaction is supported by evidence stating: 'By using different biochemical assays such as affinity preci... | |
medium_divergent_branch_06007 | NOTCH1 is implicated in multiple biological processes. One line of evidence states: 'Using primary human smooth muscle cells, we show that expression of the constitutive active ICD of human Notch1, Notch2, or Notch4 receptors increase SMA levels.' This evidence supports a specific process involving smooth muscle cells.... | smooth muscle cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06007","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NOTCH1 is implicated in multiple biological processes. One line of evidence states: 'Using primary human smooth muscle cells, we show that expression... | |
medium_divergent_branch_06008 | mmu-miR-146a-5p regulates more than one cell type. Evidence for one of these regulatory connections states: 'We identified a new molecular network that comprises specifically the NF-κB family member NF-κB1 (p50) and miR-146a, and we show that in this cell type it contributes to the regulation of cell homeostasis and su... | mast cell progenitor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06008","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"mmu-miR-146a-5p regulates more than one cell type. Evidence for one of these regulatory connections states: 'We identified a new molecular network th... | |
medium_divergent_branch_06009 | The gene MRFAP1P1 is enriched in multiple cell types. One specific enrichment profile is characterized by a mean expression of 7.69 TPM, a z-score of 1.58, and a fold enrichment of 2.40. Which cell type corresponds to this specific expression profile? | mature T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06009","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene MRFAP1P1 is enriched in multiple cell types. One specific enrichment profile is characterized by a mean expression of 7.69 TPM, a z-score of... | |
medium_divergent_branch_06012 | UFD1 interacts with multiple proteins. One interaction is supported by evidence stating: 'For many substrates, retrotranslocation requires the action of ubiquitinating enzymes, which polyubiquitinate substrates emerging from the ER lumen, and of the [ATPase complex component]-Ufd1-Npl4 ATPase complex, which hydrolyzes ... | Transitional endoplasmic reticulum ATPase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06012","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UFD1 interacts with multiple proteins. One interaction is supported by evidence stating: 'For many substrates, retrotranslocation requires the action... | |
medium_divergent_branch_06013 | FN1 interacts with multiple genes. One of these interacting partners is reported to be directly associated with FN1 and to form a complex with integrins via the association of FN1. Which disease is connected to this specific interacting gene through genomic alterations? | Ischemic stroke | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06013","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FN1 interacts with multiple genes. One of these interacting partners is reported to be directly associated with FN1 and to form a complex with integr... | |
medium_divergent_branch_06014 | The gene NR4A1 is enriched in multiple cell types. One specific cell type exhibits a mean expression of 45.61 TPM, a z-score of 2.85, and a fold enrichment of 19.14 for this gene. Which cell type does this specific cell develop from? | intermediate monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06014","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NR4A1 is enriched in multiple cell types. One specific cell type exhibits a mean expression of 45.61 TPM, a z-score of 2.85, and a fold enri... | |
medium_divergent_branch_06015 | KMT2A interacts with multiple genes. One interaction is supported by evidence stating: 'We demonstrate here that these discordant functions are unified by menin's ability to serve as a molecular adaptor that physically links the MLL (mixed-lineage leukemia) histone methyltransferase with a chromatin-associated protein ... | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06015","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KMT2A interacts with multiple genes. One interaction is supported by evidence stating: 'We demonstrate here that these discordant functions are unifi... | |
medium_divergent_branch_06016 | FGFR1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The binding of FGFR1 beta/Fc protein to a neural cell adhesion molecule was verified by immunoprecipitation of the molecule with anti-molecule mAb followed by Western blotting with FGFR1 beta/Fc.' Which molecular functio... | protein binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06016","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FGFR1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The binding of FGFR1 beta/Fc protein to a neural ... | |
medium_divergent_branch_06017 | TRPM1 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'Combined, our data demonstrate that TRPM1 proteins are bona fide ion-conducting plasma membrane channels.' Which molecular function, connected to the function supported by th... | monoatomic ion transmembrane transporter activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06017","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRPM1 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'Com... | |
medium_divergent_branch_06018 | ESCO2 interacts with multiple proteins. One of these interaction partners is distinguished by the fact that ESCO2, but not ESCO1, interacts with the MCM complex through a unique ESCO2 domain. Which protein, connected to ESCO2 via an interaction, is encoded by the gene in question? | DNA replication licensing factor MCM5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06018","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ESCO2 interacts with multiple proteins. One of these interaction partners is distinguished by the fact that ESCO2, but not ESCO1, interacts with the ... | |
medium_divergent_branch_06019 | Paneth cells are a specialized type of epithelial cell located in the basal part of the intestinal glands (crypts of Lieberkühn), including the appendix. They synthesize and secrete lysozyme and cryptdins, are numerous in the deeper parts of the intestinal crypts (particularly in the duodenum), are rich in zinc, and co... | secretory epithelial cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06019","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Paneth cells are a specialized type of epithelial cell located in the basal part of the intestinal glands (crypts of Lieberkühn), including the appen... | |
medium_divergent_branch_06020 | A chondroblast is a type of cell. One potential classification describes it as a skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, glycosaminoglycan (GAG)-rich matrix, is not buried in cartilage tissue matrix, retains the ability to divide, is located adjacent to cartilage tissue... | eukaryotic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06020","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"A chondroblast is a type of cell. One potential classification describes it as a skeletogenic cell that is typically non-terminally differentiated, s... | |
medium_divergent_branch_06021 | CLTA interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we find and structurally characterize a direct and selective interaction between CLCa and the long isoform of the actin motor protein [Gene A], which is expressed exclusively in highly polarized tissues.' Which disease is assoc... | retinal degeneration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06021","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CLTA interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we find and structurally characterize a direct and selec... | |
medium_divergent_branch_06022 | IRGM interacts with multiple proteins. One of these interaction partners is described in evidence stating: 'We further show that IRGM interacts with pattern recognition receptors including this protein.' Which protein, connected to IRGM via an interaction, is the subject of this specific evidence regarding pattern reco... | Nucleotide-binding oligomerization domain-containing protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06022","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IRGM interacts with multiple proteins. One of these interaction partners is described in evidence stating: 'We further show that IRGM interacts with ... | |
medium_divergent_branch_06025 | RC3H2 interacts with multiple genes. One of these interacting partners is a tyrosine phosphatase that specifically interacts with Roquin2 through its phosphatase domain and dephosphorylates Roquin2 at tyrosine 691. Which disease is associated with this specific interacting partner? | lymphedema-posterior choanal atresia syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06025","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RC3H2 interacts with multiple genes. One of these interacting partners is a tyrosine phosphatase that specifically interacts with Roquin2 through its... | |
medium_divergent_branch_06026 | PARD6A interacts with multiple proteins. One interaction is supported by evidence stating that ECT2 interacted with Par6 as well as Par3 and PKCzeta. Which disease is causally linked to the protein identified in this specific evidence context? | kidney cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06026","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PARD6A interacts with multiple proteins. One interaction is supported by evidence stating that ECT2 interacted with Par6 as well as Par3 and PKCzeta.... | |
medium_divergent_branch_06027 | FGFR3 interacts with multiple proteins. One interaction is supported by evidence stating: 'In the present study, we show that activation of FGFR in chondrocytes induces the expression of the shared gene and SOCS3 mRNA, and that these proteins are constitutively associated with FGFR3, as demonstrated by co-immunoprecipi... | Suppressor of cytokine signaling 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06027","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FGFR3 interacts with multiple proteins. One interaction is supported by evidence stating: 'In the present study, we show that activation of FGFR in c... | |
medium_divergent_branch_06028 | MAP3K7 interacts with multiple genes. One interaction is supported by evidence stating: 'For the first time, we found that TNF-alpha stimulation enhances the interactions between 14-3-3 epsilon and some key components in the mitogen-activated protein kinase (MAPK) signal module which is located at the immediate upstrea... | conventional dendritic cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06028","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP3K7 interacts with multiple genes. One interaction is supported by evidence stating: 'For the first time, we found that TNF-alpha stimulation enha... | |
medium_divergent_branch_06029 | The gene EPHA3 interacts with multiple partners. One specific interaction partner is characterized by evidence stating that it interacts with Ephrin receptor A3 (EphA3) and induces its ubiquitination and degradation. Which protein is encoded by this specific interacting gene? | E3 ubiquitin-protein ligase RNF5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06029","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene EPHA3 interacts with multiple partners. One specific interaction partner is characterized by evidence stating that it interacts with Ephrin ... | |
medium_divergent_branch_06030 | TAF12 interacts with multiple proteins. One specific interaction is supported by evidence describing the crystal structure of a complex formed by the interacting domains of two subunits of the general transcription factor TFIID: the human TATA binding protein-associated factors hTAF(II)135 and hTAF(II)20. Which protein... | Transcription initiation factor TFIID subunit 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06030","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TAF12 interacts with multiple proteins. One specific interaction is supported by evidence describing the crystal structure of a complex formed by the... | |
medium_divergent_branch_06031 | MDC1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We have shown that this protein facilitates the accumulation of checkpoint mediator proteins BRCA1 and 53BP1 to the damaged chromatin, on one hand through the phospho-dependent FHA domain-mediated binding of this protein ... | E3 ubiquitin-protein ligase RNF8 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06031","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MDC1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'We have shown that this protein facilitates the ac... | |
medium_divergent_branch_06033 | DEFB124 is associated with multiple biological processes. One association is supported by evidence stating that DEFB124-upregulated RWPE-1 cells markedly induced chemotactic activity for THP-1 monocytes. Which biological process is positively regulated by the process linked to this specific evidence? | monocyte chemotaxis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06033","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DEFB124 is associated with multiple biological processes. One association is supported by evidence stating that DEFB124-upregulated RWPE-1 cells mark... | |
medium_divergent_branch_06035 | SMAD7 interacts with multiple genes. One interaction is characterized by the following evidence: 'Mechanistically, we showed that the interacting partner physically interacts with SMAD7 and promotes ubiquitination-mediated degradation of SMAD7, and that SMAD7 is a key mediator of TRM37-induced hepatic fibrosis.' Which ... | ulcer disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06035","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMAD7 interacts with multiple genes. One interaction is characterized by the following evidence: 'Mechanistically, we showed that the interacting par... | |
medium_divergent_branch_06036 | The KIT gene interacts with multiple partners. One specific interaction is supported by evidence stating: 'We have identified the multiple PDZ domain containing protein (MUPP-1) as a novel binding partner of the human c-Kit.' Which disease is associated with this interaction partner via a biomarker relationship? | alcohol abuse | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06036","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The KIT gene interacts with multiple partners. One specific interaction is supported by evidence stating: 'We have identified the multiple PDZ domain... | |
medium_divergent_branch_06037 | IRS2 interacts with multiple proteins. One specific interaction is supported by the finding that IL-13 induces the association of IRS-2 with PLC-gamma 1. Which protein product is encoded by the gene corresponding to this interacting partner? | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06037","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IRS2 interacts with multiple proteins. One specific interaction is supported by the finding that IL-13 induces the association of IRS-2 with PLC-gamm... | |
medium_divergent_branch_06038 | Primate erythroparvovirus 1 upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 2.018 and an adjusted p-value of 0.0357. For which disease is that selected gene recorded as a biomarker? | lichen planus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06038","source_qa_id":"medium_divergent_branch_06591","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Primate erythroparvovirus 1 upregulates several genes. In the recorded experiment, one branch ... | |
medium_divergent_branch_06039 | LIN9 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Activation of these genes is linked to an association between LIN-9 and a partner protein.' Which protein is encoded by the gene corresponding to the partner in this specific LIN9 interaction? | Myb-related protein B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06039","source_qa_id":"medium_divergent_branch_05659","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"LIN9 interacts with multiple proteins. One specific interaction is supported by evidence stating:... | |
medium_divergent_branch_06040 | The leukemia inhibitory factor receptor (LIFR) is associated with multiple biological processes. One specific association is supported by evidence describing its receptor complex: it consists of a ligand-binding component, the CNTF receptor (CNTFR), associated with two signaling receptor components, gp130 and LIFR. Bas... | cell surface receptor signaling pathway | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06040","source_qa_id":"medium_divergent_branch_05837","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The leukemia inhibitory factor receptor (LIFR) is associated with multiple biological processes. ... | |
medium_divergent_branch_06041 | FBLN1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We report here that the C-terminal domain confers on the full-length NOVH protein the capacity to bind fibulin 1C, a protein of the extracellular matrix that interacts with several other regulators of cell adhesion.' Which protei... | CCN family member 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06041","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FBLN1 interacts with multiple proteins. One interaction is supported by evidence stating: 'We report here that the C-terminal domain confers on the f... | |
medium_divergent_branch_06042 | PSMC1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Herein, we show that a protein interacts with the ATPase subunit S4 of the proteasomal 19S regulatory complex.' Which disease is associated with the gene identified in this evidence? | spinocerebellar ataxia 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06042","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PSMC1 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Herein, we show that a protein interacts with the AT... | |
medium_divergent_branch_06043 | KCNA5 interacts with multiple partner genes. One specific interaction is supported by evidence stating that both GIP and GLP-1 increase the phosphorylation and acetylation of Kv1.5 and its Kvβ2 protein subunit, thereby enhancing their interaction. Which biological process is the gene corresponding to this specific inte... | regulation of potassium ion transmembrane transport | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06043","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KCNA5 interacts with multiple partner genes. One specific interaction is supported by evidence stating that both GIP and GLP-1 increase the phosphory... | |
medium_divergent_branch_06044 | PF4 is associated with multiple biological processes. One association is supported by evidence stating: 'The present study shows that PF4 is essential for platelet aggregation triggered by the antibodies related to HIT in the presence of heparin.' Which biological process, connected to the process supported by this evi... | blood coagulation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06044","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PF4 is associated with multiple biological processes. One association is supported by evidence stating: 'The present study shows that PF4 is essentia... | |
medium_divergent_branch_06045 | The protein AFG3L2 is associated with multiple biological processes. One of these associations is supported by evidence describing a structure that identifies specialized features integrating with conserved motifs required for ATP-dependent translocation to unfold and degrade targeted proteins. Which broader biological... | protein processing | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06045","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein AFG3L2 is associated with multiple biological processes. One of these associations is supported by evidence describing a structure that i... | |
medium_divergent_branch_06046 | The gene NEUROG3 is associated with multiple biological processes. One specific association is supported by evidence stating that NEUROG3 plays a central role in the development of both pancreatic islets and enteroendocrine cells. Which biological process, connected to this specific process via an 'is a' relationship, ... | epithelial cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06046","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NEUROG3 is associated with multiple biological processes. One specific association is supported by evidence stating that NEUROG3 plays a cen... | |
medium_divergent_branch_06047 | LGALS3BP interacts with multiple proteins. One specific interaction involves a partner that directly binds to galectin-3-binding protein (LGALS3BP) and forms a complex with the E3 ubiquitin ligase TRIM38, thereby facilitating the ubiquitination-mediated degradation of LGALS3BP at the K104 residue. Which protein is enco... | Ubiquitin-conjugating enzyme E2 G2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06047","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LGALS3BP interacts with multiple proteins. One specific interaction involves a partner that directly binds to galectin-3-binding protein (LGALS3BP) a... | |
medium_divergent_branch_06048 | Cardiac mesenchymal cells are a type of cell found in the developing heart that contribute to various cardiac structures. These cells originate from multiple sources, including the endocardium, epicardium, neural crest, and second heart field. Based on this description, which specific cell type is being described, and ... | cardiac neural crest | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06048","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Cardiac mesenchymal cells are a type of cell found in the developing heart that contribute to various cardiac structures. These cells originate from ... | |
medium_divergent_branch_06049 | ZNF451 interacts with multiple proteins. One interaction partner is described as follows: 'In keeping with its interaction with SUMO E2 conjugase [REDACTED] and SUMOs, ZNF451 is covalently modified by SUMOs (sumoylated) at several, albeit nonconsensus, sites.' Which protein, encoded by the gene interacting with ZNF451 ... | SUMO-conjugating enzyme UBC9 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06049","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZNF451 interacts with multiple proteins. One interaction partner is described as follows: 'In keeping with its interaction with SUMO E2 conjugase [RE... | |
medium_divergent_branch_06050 | FYN interacts with multiple proteins. One interaction is supported by evidence stating that Src homology 3 domains from several Src family PTKs, including Lck, Abl, and Src, associate with the target protein in vitro. Which protein is this target, and what is the name of the protein product it encodes? | Disintegrin and metalloproteinase domain-containing protein 15 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06050","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FYN interacts with multiple proteins. One interaction is supported by evidence stating that Src homology 3 domains from several Src family PTKs, incl... | |
medium_divergent_branch_06051 | LATS2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Physical interactions were observed between Aurora A, Lats2, Lats1 and Aurora B.' Which protein, encoded by the gene connected to LATS2 via this specific interaction, is the subject of this evidence? | Aurora kinase B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06051","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LATS2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Physical interactions were observed between Aurora A, Lats... | |
medium_divergent_branch_06052 | The gene PPP2CB interacts with multiple partners. One specific interaction involves the PP2A holoenzyme associating with separase via the B' (B56) regulatory subunit, a process that occurs independently of securin and cyclin B1 binding. Which protein is encoded by the gene that participates in this specific interaction... | Separin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06052","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PPP2CB interacts with multiple partners. One specific interaction involves the PP2A holoenzyme associating with separase via the B' (B56) re... | |
medium_divergent_branch_06053 | AMBRA1 interacts with multiple proteins. Evidence for one of these interactions states: 'Under normal conditions, Cullin-4 binding to AMBRA1 limits its protein abundance.' Which protein is encoded by the gene that interacts with AMBRA1 in this specific context? | Cullin-4A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06053","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AMBRA1 interacts with multiple proteins. Evidence for one of these interactions states: 'Under normal conditions, Cullin-4 binding to AMBRA1 limits i... | |
medium_divergent_branch_06055 | GRK6 is reported to interact with multiple proteins. One specific interaction is described in a study characterizing the interaction of a calcium-binding protein with GRK6 and GRK2, members of the G protein-coupled receptor kinase family, and their phosphorylation of this protein. Which protein, linked to GRK6 by this ... | Calsenilin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06055","source_qa_id":"medium_divergent_branch_05114","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"GRK6 is reported to interact with multiple proteins. One specific interaction is described in a s... | |
medium_divergent_branch_06056 | Tenascin-C (TNC) interacts with multiple proteins. One specific interaction was confirmed by co-immunoprecipitation and further analyzed by Surface Plasmon Resonance Spectroscopy, revealing an apparent dissociation constant (K(D)) of 2.59×10⁻⁹ M. Which protein corresponds to this high-affinity interaction partner? | SPARC-related modular calcium-binding protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06056","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Tenascin-C (TNC) interacts with multiple proteins. One specific interaction was confirmed by co-immunoprecipitation and further analyzed by Surface P... | |
medium_divergent_branch_06057 | PTBP1 interacts with multiple proteins. One of these interaction partners drives glycolysis by binding to PTBP1 to facilitate the mRNA splicing of PKM2. Which protein is encoded by the gene corresponding to this specific interaction partner? | Protein phosphatase 1 regulatory subunit 26 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06057","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTBP1 interacts with multiple proteins. One of these interaction partners drives glycolysis by binding to PTBP1 to facilitate the mRNA splicing of PK... | |
medium_divergent_branch_06058 | RAD50 interacts with multiple proteins. One of these interaction partners is described as physically associating with the MRE11-RAD50-NBS1 (MRN) complex and ubiquitinating MRE11 at lysine residues 339 and 480. This modification increases MRE11's DNA exonuclease activity, subsequent RPA binding, and ATR phosphorylation,... | E3 ubiquitin-protein ligase RNF126 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06058","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAD50 interacts with multiple proteins. One of these interaction partners is described as physically associating with the MRE11-RAD50-NBS1 (MRN) comp... | |
medium_divergent_branch_06059 | MIR29A is associated with multiple biological processes. One association is supported by evidence that miR-29a negatively regulates collagen IV by directly targeting the 3'UTRs of col4a1 and col4a2. Which biological process is connected to the process supported by this evidence through the relation 'negatively regulate... | collagen biosynthetic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06059","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR29A is associated with multiple biological processes. One association is supported by evidence that miR-29a negatively regulates collagen IV by di... | |
medium_divergent_branch_06060 | COPE interacts with multiple proteins. One interaction partner was identified in a study that reported, for the first time, members of the coatomer I (COPI) complex as interaction partners of hSAC1. Which protein product is encoded by this specific interaction partner of COPE? | Phosphatidylinositol-3-phosphatase SAC1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06060","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"COPE interacts with multiple proteins. One interaction partner was identified in a study that reported, for the first time, members of the coatomer I... | |
medium_divergent_branch_06061 | The RB1 protein interacts with multiple partners. One specific interaction partner is a protein that utilizes two distinct regions to bind Rb and the thyroid hormone receptor (TR), leading to its designation as a specific TR-interacting protein. In which cellular component is this specific interaction partner located? | endoplasmic reticulum-Golgi intermediate compartment | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06061","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The RB1 protein interacts with multiple partners. One specific interaction partner is a protein that utilizes two distinct regions to bind Rb and the... | |
medium_divergent_branch_06062 | DDOST interacts with multiple genes. One of these interactions is supported by evidence stating: 'Co-immunoprecipitation studies confirmed a robust and specific physical interaction between a keratin-associated protein and STT3A, and revealed weaker associations with both STT3B and OST48.' Which biological process is t... | protein N-linked glycosylation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06062","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DDOST interacts with multiple genes. One of these interactions is supported by evidence stating: 'Co-immunoprecipitation studies confirmed a robust a... | |
medium_divergent_branch_06063 | MYCBP2 interacts with multiple genes. One of these interaction partners is described in a study reporting that two E3 ligases, Arf-bp1 and Pam (Myc-bp2), copurified with Rev-erb alpha and were required for its ubiquitination. Which disease is connected to this specific interaction partner through a biomarker relationsh... | breast benign neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06063","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MYCBP2 interacts with multiple genes. One of these interaction partners is described in a study reporting that two E3 ligases, Arf-bp1 and Pam (Myc-b... | |
medium_divergent_branch_06064 | STX7 is involved in multiple biological processes. One specific process is characterized by evidence showing that in STX7-deprived cytotoxic T lymphocytes (CTLs), lytic granules fail to fuse with the plasma membrane and fail to accumulate at the immunological synapse (IS). This accumulation defect is attributed not to ... | receptor localization to synapse | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06064","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STX7 is involved in multiple biological processes. One specific process is characterized by evidence showing that in STX7-deprived cytotoxic T lympho... | |
medium_divergent_branch_06066 | RNF34 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Further investigation revealed that ring finger protein 34 (RNF34) was recruited to interact with this protein thereby facilitating autophagic degradation of MAVS through K27-linked polyubiquitination of MAVS.' What is t... | Tax1-binding protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06066","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF34 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Further investigation revealed that ring finger p... | |
medium_divergent_branch_06067 | The gene PPP1R12A interacts with multiple other genes. One of these interaction partners is supported by evidence stating that Myosin phosphatase-targeting subunit 1 (MYPT1) binds to the catalytic subunit of protein phosphatase 1. Which protein is encoded by the gene that interacts with PPP1R12A and is associated with ... | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06067","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PPP1R12A interacts with multiple other genes. One of these interaction partners is supported by evidence stating that Myosin phosphatase-tar... | |
medium_divergent_branch_06068 | ARHGDIA is known to interact with multiple proteins. One specific interaction partner was described in a study as a 'newly discovered' entity that 'interacted very poorly with Rho-GDI'. Which protein is encoded by the gene corresponding to this specific interaction partner? | Rho-related GTP-binding protein RhoH | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06068","source_qa_id":"medium_divergent_branch_00649","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ARHGDIA is known to interact with multiple proteins. One specific interaction partner was describ... | |
medium_divergent_branch_06070 | IPCEF1 interacts with multiple genes. One of these interacting partners is noted to also interact with other members of the cytohesin family of ARF GEFs, suggesting that this interaction is highly conserved within that family. Which protein is encoded by this specific interacting gene? | Cytohesin-4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06070","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IPCEF1 interacts with multiple genes. One of these interacting partners is noted to also interact with other members of the cytohesin family of ARF G... | |
medium_divergent_branch_06071 | PRKG1 interacts with multiple genes. One interaction is supported by evidence that PKGI-alpha binds directly to and phosphorylates RGS-2, significantly increasing the GTPase activity of G(q) and terminating PAR-1 signaling. Which disease is associated with the gene described in this specific interaction through genomic... | post-traumatic stress disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06071","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKG1 interacts with multiple genes. One interaction is supported by evidence that PKGI-alpha binds directly to and phosphorylates RGS-2, significant... | |
medium_divergent_branch_06072 | IRF4 interacts with multiple genes. One interaction is supported by evidence stating: 'Here we show that NOD2 activation results in increased interferon regulatory factor 4 (IRF4) expression and binding to tumor necrosis factor receptor associated factor 6 (TRAF6) and a receptor interacting serine-threonine kinase.' Wh... | eosinophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06072","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IRF4 interacts with multiple genes. One interaction is supported by evidence stating: 'Here we show that NOD2 activation results in increased interfe... | |
medium_divergent_branch_06073 | RAB5A interacts with multiple proteins. One interaction is supported by evidence showing that sensors fused to cyan fluorescent protein (CFP) exhibited fluorescence resonance energy transfer (FRET) with GTP-bound Rab5. Which protein, encoded by the gene connected to RAB5A via this specific interaction evidence, is the ... | Early endosome antigen 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06073","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAB5A interacts with multiple proteins. One interaction is supported by evidence showing that sensors fused to cyan fluorescent protein (CFP) exhibit... | |
medium_divergent_branch_06074 | CAB39 interacts with multiple genes. One interaction is supported by evidence stating: 'In vivo, a serine/threonine kinase forms a complex with STRAD, an inactive pseudokinase, and MO25, an armadillo repeat scaffolding-like protein.' Which protein is encoded by the gene connected to CAB39 via this specific interaction? | Serine/threonine-protein kinase STK11 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06074","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CAB39 interacts with multiple genes. One interaction is supported by evidence stating: 'In vivo, a serine/threonine kinase forms a complex with STRAD... | |
medium_divergent_branch_06075 | The biological process 'regulation of starch catabolic process' is a subtype of a broader regulatory process. Evidence for this relationship states: 'Any process that modulates the frequency, rate or extent of starch catabolic process.' Which biological process is directly regulated by this broader regulatory process? | carbohydrate catabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06075","source_qa_id":"medium_divergent_branch_05831","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The biological process 'regulation of starch catabolic process' is a subtype of a broader regulat... | |
medium_divergent_branch_06076 | TRIM59 interacts with multiple genes. One specific interaction is characterized by the following mechanism: in response to the onset of colitis, TRIM59 directly interacts with the partner protein to promote its ubiquitin-proteasome degradation. This process results in NRF2 activation and the subsequent activation of do... | malignant peripheral nerve sheath tumor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06076","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM59 interacts with multiple genes. One specific interaction is characterized by the following mechanism: in response to the onset of colitis, TRIM... | |
medium_divergent_branch_06077 | CUL3 interacts with multiple proteins. One specific interaction involves a human BTB-Kelch protein that acts as a negative regulator of the antioxidative transcription factor NFE2L2. This protein binds to CUL3 via its BTB domain and to NFE2L2 via its Kelch domain. Which disease is associated with this specific interact... | immunodeficiency, developmental delay, and hypohomocysteinemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06077","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CUL3 interacts with multiple proteins. One specific interaction involves a human BTB-Kelch protein that acts as a negative regulator of the antioxida... | |
medium_divergent_branch_06078 | FOXP3 interacts with multiple genes. One of these interacting partners is a kinase that directly phosphorylates FOXP3, thereby increasing FOXP3 protein stability. Which disease is associated with this specific interacting partner? | carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06078","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXP3 interacts with multiple genes. One of these interacting partners is a kinase that directly phosphorylates FOXP3, thereby increasing FOXP3 prote... | |
medium_divergent_branch_06079 | LRWD1 interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'We demonstrate that ORCA associates with the E3 ubiquitin ligase Cul4A-Ddb1.' Which protein is encoded by the gene connected to LRWD1 via this specific interaction? | Origin recognition complex subunit 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06079","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LRWD1 interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'We demonstrate that ORCA associates with th... | |
medium_divergent_branch_06080 | STAT1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Via immunoprecipitation and Glutathione S-transferase assay, we found that the protein could interact with STAT1 directly and suppress its degradation by suppressing K48-type ubiquitination in response to hypertrophic st... | TNFAIP3-interacting protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06080","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"STAT1 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Via immunoprecipitation and Glutathione S-transfe... | |
medium_divergent_branch_06081 | UBAC1 interacts with multiple proteins. One interaction is supported by evidence stating: 'By means of a yeast two-hybrid screening, we identified the UBA Domain Containing 1 (UBAC1), the non-catalytic subunit of the E3 ubiquitin-protein ligase KPC complex, as an interactor of a specific protein.' Which protein, connec... | Caspase recruitment domain-containing protein 14 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06081","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBAC1 interacts with multiple proteins. One interaction is supported by evidence stating: 'By means of a yeast two-hybrid screening, we identified th... | |
medium_divergent_branch_06082 | The gene A2M interacts with multiple partners. One interaction is supported by evidence stating: 'The molecule was bound by antibodies against human alpha 2-macroglobulin, and experiments with antisera against the three alpha-macroglobulin variants in rat serum, alpha 1-macroglobulin, alpha 2-macroglobulin, and alpha 1... | Protein AMBP | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06082","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene A2M interacts with multiple partners. One interaction is supported by evidence stating: 'The molecule was bound by antibodies against human ... | |
medium_divergent_branch_06083 | TOP2B interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The specific interaction in cells was evidenced by co-immunoprecipitation of topoII beta and the interaction partner from the nuclear fraction of T cells.' Which protein is encoded by the gene that interacts with TOP2B i... | T-cell surface glycoprotein CD3 epsilon chain | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06083","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TOP2B interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The specific interaction in cells was evidenced b... | |
medium_divergent_branch_06084 | PCM1 interacts with multiple proteins. One specific interaction is characterized by being phosphorylation-dependent, with CDK1 acting as the priming kinase to facilitate the binding. Which protein, connected to PCM1 via this specific interaction, is encoded by the gene in question? | Serine/threonine-protein kinase PLK1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06084","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PCM1 interacts with multiple proteins. One specific interaction is characterized by being phosphorylation-dependent, with CDK1 acting as the priming ... | |
medium_divergent_branch_06085 | WNT10B is associated with multiple biological processes. One association is supported by evidence stating: 'A subset of those genes (wnt2b, wnt5b, wnt10b, fzd6, fzd7) showed altered expression in hDFs exposed to DBP for 3 days.' Which biological process, connected to the process linked by this evidence via a 'part of' ... | cartilage development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06085","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WNT10B is associated with multiple biological processes. One association is supported by evidence stating: 'A subset of those genes (wnt2b, wnt5b, wn... | |
medium_divergent_branch_06086 | RPTOR interacts with multiple proteins. One interaction is supported by evidence stating that Raptor is a 150 kDa mTOR binding protein that also binds 4EBP1 and p70alpha. Which protein, connected to RPTOR via this specific interaction evidence, is encoded by the gene in question? | Ribosomal protein S6 kinase beta-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06086","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RPTOR interacts with multiple proteins. One interaction is supported by evidence stating that Raptor is a 150 kDa mTOR binding protein that also bind... | |
medium_divergent_branch_06087 | GATA4 interacts with multiple genes. One specific interaction is supported by evidence stating that 'Glutathione-S-transferase pull-down experiments and coimmunoprecipitation demonstrated interaction between GATA-4 or GATA-6 and this transcription factor, but not Sp3.' Which disease is causally linked to this gene? | stroke disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06087","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GATA4 interacts with multiple genes. One specific interaction is supported by evidence stating that 'Glutathione-S-transferase pull-down experiments ... | |
medium_divergent_branch_06088 | The protein DIABLO interacts with multiple partners. One of these partners is documented to interact with and ubiquitinate IAP antagonists such as SMAC, HtrA2, and ARTS. Which gene encodes this specific interacting partner? | Apoptosis-resistant E3 ubiquitin protein ligase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06088","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein DIABLO interacts with multiple partners. One of these partners is documented to interact with and ubiquitinate IAP antagonists such as SM... | |
medium_divergent_branch_06089 | Peristalsis is associated with multiple anatomical structures. One of these structures is described as one of two ganglionated neural networks that together form the enteric nervous system. Specifically, the myenteric (Auerbach's) plexus is located between the longitudinal and circular muscle layers of the gut. Its neu... | enteric plexus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06089","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Peristalsis is associated with multiple anatomical structures. One of these structures is described as one of two ganglionated neural networks that t... | |
medium_divergent_branch_06090 | SOX15 is associated with multiple biological processes. One association is supported by evidence stating: 'The preferential expression of SOX15 in the myogenic precursor cells led us to suggest that SOX15 is involved in the specification of myogenic cell lineages or in the regulation of the fusion of myoblasts to form ... | myoblast differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06090","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SOX15 is associated with multiple biological processes. One association is supported by evidence stating: 'The preferential expression of SOX15 in th... | |
medium_divergent_branch_06092 | SLC7A11 interacts with multiple genes. One of these interacting partners is characterized by evidence showing that it directly interacts with and stabilizes SLC7A11, and that its knockdown reduces SLC7A11 levels in cancer cells. Which disease is associated with this specific interacting gene via a biomarker relationshi... | malignant colon neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06092","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SLC7A11 interacts with multiple genes. One of these interacting partners is characterized by evidence showing that it directly interacts with and sta... | |
medium_divergent_branch_06093 | EHMT2 interacts with multiple proteins. One of these interaction partners is described by the following evidence: 'Here we show that this protein binds histone lysine methyltransferase G9a, and both are co-localized in the nucleus in a cell-cycle-dependent manner.' What is the name of the protein encoded by this gene? | E3 ubiquitin-protein ligase UHRF1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06093","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EHMT2 interacts with multiple proteins. One of these interaction partners is described by the following evidence: 'Here we show that this protein bin... | |
medium_divergent_branch_06094 | DCUN1D3 interacts with multiple proteins. One interaction partner is described in a study stating: 'We found that although SCCRO3 binds to this protein, cullins, and ROC1, it does not efficiently bind to Ubc12, promote cullin neddylation, or conform to the reaction processivity paradigms, suggesting that SCCRO3 does no... | Cullin-associated NEDD8-dissociated protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06094","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DCUN1D3 interacts with multiple proteins. One interaction partner is described in a study stating: 'We found that although SCCRO3 binds to this prote... | |
medium_divergent_branch_06095 | NECTIN2 is associated with multiple biological processes. One specific association is supported by evidence showing that blocking CD112 (NECTIN2) on eosinophils with neutralizing antibodies normalized the hyperactivity resulting from IgE-dependent activation of mast cells in co-culture. Which biological process is posi... | mast cell activation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06095","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NECTIN2 is associated with multiple biological processes. One specific association is supported by evidence showing that blocking CD112 (NECTIN2) on ... | |
medium_divergent_branch_06096 | BIRC6 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Here we report that Apollon binds to, ubiquitinates and facilitates proteasomal degradation of SMAC and a caspase, which both contain IAP-binding motifs.' Which disease is associated with the gene identified by this eviden... | mantle cell lymphoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06096","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BIRC6 interacts with multiple genes. One of these interactions is supported by evidence stating: 'Here we report that Apollon binds to, ubiquitinates... | |
medium_divergent_branch_06097 | The protein EIF5 is associated with multiple biological processes. One specific association is supported by evidence stating that the entity stimulates the hydrolysis of eIF2-bound GTP, leading to the release of eIF2 from the 48S pre-initiation complex at the start codon, prior to the joining of the 60S subunit to form... | membraneless organelle assembly | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06097","source_qa_id":"medium_divergent_branch_06464","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The protein EIF5 is associated with multiple biological processes. One specific association is su... | |
medium_divergent_branch_06098 | AGRP interacts with multiple proteins. One specific interaction is supported by evidence stating that Agouti-related protein is an endogenous antagonist of a specific G-protein coupled receptor, which functions in the hypothalamic control of feeding behavior. Which protein is encoded by the gene corresponding to this s... | Melanocortin receptor 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06098","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AGRP interacts with multiple proteins. One specific interaction is supported by evidence stating that Agouti-related protein is an endogenous antagon... | |
medium_divergent_branch_06099 | SH3KBP1 interacts with multiple genes. One interaction is supported by evidence stating: 'Binding assays with different CIN85/Ruk isoforms and mutants showed that nephrin and podocin are binding to the coiled-coil domain of CIN85/Ruk(L).' Identify the disease associated with the gene implicated in this specific interac... | malignant colon neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06099","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SH3KBP1 interacts with multiple genes. One interaction is supported by evidence stating: 'Binding assays with different CIN85/Ruk isoforms and mutant... | |
medium_divergent_branch_06100 | PSEN1 interacts with multiple genes. One interaction is supported by evidence stating: 'The carboxyl terminus of presenilin 1 and 2 (PS1 and PS2) binds to the neuron-specific cell adhesion molecule telencephalin in the brain.' Which disease is associated with the gene identified by this specific interaction evidence th... | breast carcinoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06100","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PSEN1 interacts with multiple genes. One interaction is supported by evidence stating: 'The carboxyl terminus of presenilin 1 and 2 (PS1 and PS2) bin... | |
medium_divergent_branch_06101 | SNAPIN interacts with multiple genes. One interaction is supported by evidence stating: 'We herein provide evidence that the same 69-residue region of the interacting partner that is sufficient for dystrobrevin binding in vitro also contains the binding sites for pallidin and SNAPIN, and at least part of the muted-bind... | natural killer cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06101","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SNAPIN interacts with multiple genes. One interaction is supported by evidence stating: 'We herein provide evidence that the same 69-residue region o... | |
medium_divergent_branch_06102 | RAB6A is associated with multiple biological processes. One specific association is supported by evidence that GCC185 binds Rab6, and that mutating residues required for this binding abolishes Golgi localization. Which cellular component is the target end location of this specific biological process? | Golgi apparatus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06102","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RAB6A is associated with multiple biological processes. One specific association is supported by evidence that GCC185 binds Rab6, and that mutating r... | |
medium_divergent_branch_06103 | PTPRF interacts with multiple proteins. One interaction partner was identified using an interaction-trap assay targeting the cytoplasmic region of the LAR transmembrane protein tyrosine phosphatase (PT-Pase). The isolated cDNA encodes a 2861-amino acid protein containing three enzyme domains: two functional GEF domains... | Triple functional domain protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06103","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PTPRF interacts with multiple proteins. One interaction partner was identified using an interaction-trap assay targeting the cytoplasmic region of th... | |
medium_divergent_branch_06104 | TMED10 is associated with multiple biological processes. One association is supported by evidence stating: 'We identify TMED10 as a protein channel for the vesicle entry and secretion of many leaderless cargoes.' Which biological process is positively regulated by the process linked to TMED10 via this specific evidence... | protein secretion | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06104","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TMED10 is associated with multiple biological processes. One association is supported by evidence stating: 'We identify TMED10 as a protein channel f... |
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