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medium_divergent_branch_06105 | NRF1 interacts with multiple genes. One interaction is supported by evidence stating: 'Saturation screening of both mouse embryo and mouse testis libraries yielded 14 independent clones, all of which represented two different isoforms of dynein light chain.' Which disease is associated with the gene identified by this ... | breast cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06105","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NRF1 interacts with multiple genes. One interaction is supported by evidence stating: 'Saturation screening of both mouse embryo and mouse testis lib... | |
medium_divergent_branch_06106 | Chondrocytes are structural components of multiple anatomical entities. One such entity is described as an avascular skeletal tissue rich in glycosaminoglycans (GAGs), where chondrocytes reside within isolated lacunae and the extracellular matrix is deposited by chondroblasts. Which anatomical system's morphology is co... | skeletal system | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06106","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Chondrocytes are structural components of multiple anatomical entities. One such entity is described as an avascular skeletal tissue rich in glycosam... | |
medium_divergent_branch_06108 | DLC1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Interestingly, both proteins were found to colocalize at the plasma membrane and interacted physically in biochemical pulldowns and coimmunoprecipitations.' Which protein, connected to DLC1 via this specific interaction evidence, ... | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06108","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DLC1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Interestingly, both proteins were found to colocalize at th... | |
medium_divergent_branch_06109 | TRIM69 interacts with multiple proteins. One interaction is supported by evidence stating: 'We identify Serine/threonine-protein kinase 3 (MST2) as a new direct binding partner of TRIM69.' Which protein, connected to TRIM69 via an interaction, is the subject of this specific evidence? | Serine/threonine-protein kinase 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06109","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM69 interacts with multiple proteins. One interaction is supported by evidence stating: 'We identify Serine/threonine-protein kinase 3 (MST2) as a... | |
medium_divergent_branch_06110 | SORBS1 interacts with multiple genes. One of these interacting partners was observed in human hepatoma Hep3B cells to partly dissociate from the insulin receptor complex and bind to a tyrosine kinase protein upon insulin stimulation. Which disease is associated with this specific interacting gene through genomic altera... | T-cell childhood acute lymphocytic leukemia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06110","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SORBS1 interacts with multiple genes. One of these interacting partners was observed in human hepatoma Hep3B cells to partly dissociate from the insu... | |
medium_divergent_branch_06111 | PDCD6 interacts with multiple genes. One of these interaction partners is a regulator of store-operated Ca2+ entry (SOCE) whose cytosolic domain interacts with ALG-2, a penta-EF-hand Ca2+-binding protein. Which gene is this interaction partner? | SEL1L | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06111","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PDCD6 interacts with multiple genes. One of these interaction partners is a regulator of store-operated Ca2+ entry (SOCE) whose cytosolic domain inte... | |
medium_divergent_branch_06112 | NCS1 interacts with multiple genes. One of these interaction partners is described as a protein that associates in vivo with a specific phosphatidylinositol 4-kinase and colocalizes with the enzyme in the Golgi region. Which disease is associated with this specific interaction partner? | hearing loss, autosomal dominant 87 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06112","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NCS1 interacts with multiple genes. One of these interaction partners is described as a protein that associates in vivo with a specific phosphatidyli... | |
medium_divergent_branch_06113 | RIMS1 interacts with multiple proteins. One of these interaction partners is supported by evidence stating: 'The yeast two-hybrid technique identified 14-3-3 proteins as ligands of the N-terminal domain.' Which protein is encoded by the gene corresponding to this specific interaction partner? | 14-3-3 protein eta | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06113","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RIMS1 interacts with multiple proteins. One of these interaction partners is supported by evidence stating: 'The yeast two-hybrid technique identifie... | |
medium_divergent_branch_06114 | SOCS1 interacts with multiple proteins. One of these interaction partners physically binds to SOCS1 and enhances its stability by removing K48-linked polyubiquitin chains, thereby counteracting proteasomal degradation. Which protein is encoded by the gene corresponding to this specific interaction partner? | Josephin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06114","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SOCS1 interacts with multiple proteins. One of these interaction partners physically binds to SOCS1 and enhances its stability by removing K48-linked... | |
medium_divergent_branch_06115 | CHUK interacts with multiple genes. One of these interaction partners is implicated in a context where mutants unable to activate NF-kappaB still retain their ability to associate with the IKK complex, as confirmed by immunoprecipitation analysis. Which disease is connected to this specific gene through a protective re... | diabetes mellitus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06115","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHUK interacts with multiple genes. One of these interaction partners is implicated in a context where mutants unable to activate NF-kappaB still ret... | |
medium_divergent_branch_06116 | MAPK8 interacts with multiple proteins. One of these interaction partners is reported to associate with JNK1 in vivo in Jurkat T cells via coimmunoprecipitation and to bind directly to JNK1 in a yeast two-hybrid assay. Which protein is encoded by the gene corresponding to this interaction partner? | Proto-oncogene c-Rel | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06116","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAPK8 interacts with multiple proteins. One of these interaction partners is reported to associate with JNK1 in vivo in Jurkat T cells via coimmunopr... | |
medium_divergent_branch_06117 | ATP1A2 interacts with multiple proteins. One interaction partner is described by the following evidence: 'On membranes, this protein and ZNRF2 interact with the Na(+)/K(+)ATPase α1 subunit via their UBZ domains.' What is the full protein name encoded by this gene? | E3 ubiquitin-protein ligase ZNRF1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06117","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATP1A2 interacts with multiple proteins. One interaction partner is described by the following evidence: 'On membranes, this protein and ZNRF2 intera... | |
medium_divergent_branch_06118 | MEF2A interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The interaction was confirmed by a glutathione S-transferase-pull down assay and a co-immunoprecipitation study indicating that endogenous [protein encoded by MAPK7] and MEF2 interact with each other in vivo.' Which prot... | Mitogen-activated protein kinase 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06118","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MEF2A interacts with multiple proteins. One specific interaction is supported by evidence stating: 'The interaction was confirmed by a glutathione S-... | |
medium_divergent_branch_06119 | EYA2 interacts with multiple proteins. One of these interaction partners is known to interact with activated Galpha(z) and at least one other member of the Galpha(i) family, specifically Galpha(i2). Which protein, encoded by the gene connected to EYA2 via this specific interaction, is the subject of this description? | Guanine nucleotide-binding protein G(i) subunit alpha-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06119","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EYA2 interacts with multiple proteins. One of these interaction partners is known to interact with activated Galpha(z) and at least one other member ... | |
medium_divergent_branch_06120 | The gene CRYBB2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Chloramphenicol acetyltransferase activity indicated that there were interactions between alphaA- (or alphaB-) and betaB2- or gammaC-crystallins but with an intensity of one-third that of alphaA-alphaB interactions.' Wh... | Gamma-crystallin C | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06120","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CRYBB2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Chloramphenicol acetyltransferase activity indic... | |
medium_divergent_branch_06121 | MAP2K3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Coimmunoprecipitation demonstrated that endogenous [Protein X] specifically associates with MEK3 and MEK6 providing one mechanism for preferential recognition of MEKs upstream of p38.' Which protein, encoded by the gene interact... | Serine/threonine-protein kinase TAO2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06121","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP2K3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Coimmunoprecipitation demonstrated that endogenous [Prote... | |
medium_divergent_branch_06122 | HIC1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using a yeast two-hybrid approach, we identify this protein, a subunit of the NuRD complex, as a new HIC1 corepressor.' What is the name of the protein encoded by this gene? | Metastasis-associated protein MTA1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06122","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HIC1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Using a yeast two-hybrid approach, we identify this protein... | |
medium_divergent_branch_06123 | MAP3K7 interacts with multiple genes. One of these interacting partners is reported to associate with TAK1 upon TNFα induction, leading to the deubiquitination of TAK1 and the subsequent downregulation of TAK1-mediated NF-κB activation. Which disease is associated with this specific interacting gene via a biomarker rel... | male infertility | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06123","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP3K7 interacts with multiple genes. One of these interacting partners is reported to associate with TAK1 upon TNFα induction, leading to the deubiq... | |
medium_divergent_branch_06124 | TP53BP1 interacts with multiple genes. One of these interactions is supported by evidence stating that 53BP1 and a specific interacting partner form a stable complex required for their expression. Which protein is encoded by the gene connected to TP53BP1 via this specific interaction? | Tudor-interacting repair regulator protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06124","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TP53BP1 interacts with multiple genes. One of these interactions is supported by evidence stating that 53BP1 and a specific interacting partner form ... | |
medium_divergent_branch_06125 | ZFP36L1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'In addition, we demonstrate that both ZFP36 and ZFP36L1 influence keratinocyte cell cycle, differentiation, and apoptosis in a distinct manner.' Identify the biological process that is the direct target... | keratinocyte apoptotic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06125","source_qa_id":"medium_divergent_branch_01020","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ZFP36L1 is associated with multiple biological processes. One specific association is supported b... | |
medium_divergent_branch_06126 | GIPC1 interacts with multiple genes. One of these interaction partners is described in evidence stating that GLUT1CBP can bind to native GLUT1, self-associate, or interact with cytoskeletal proteins including myosin VI, alpha-actinin-1, and the kinesin superfamily protein KIF-1B. Which cellular component is the gene id... | mitochondrion | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06126","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GIPC1 interacts with multiple genes. One of these interaction partners is described in evidence stating that GLUT1CBP can bind to native GLUT1, self-... | |
medium_divergent_branch_06127 | IRAK1 interacts with multiple genes. One of these interaction partners is described as a major member of antioxidant enzymes, and mechanistic evidence indicates that IRAK1 binds to this partner, thereby preventing its ubiquitination and degradation mediated by the E3 ubiquitin ligase HECTD3. Which disease is therapeuti... | schistosomiasis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06127","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IRAK1 interacts with multiple genes. One of these interaction partners is described as a major member of antioxidant enzymes, and mechanistic evidenc... | |
medium_divergent_branch_06128 | GATA3 is associated with multiple biological processes. One association is supported by evidence stating: 'These results show that GATA3 is essential in the embryonic development of the parathyroids, auditory system and kidneys.' Which broader biological process is the specific process linked to GATA3 by this evidence ... | developmental process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06128","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GATA3 is associated with multiple biological processes. One association is supported by evidence stating: 'These results show that GATA3 is essential... | |
medium_divergent_branch_06129 | Primate erythroparvovirus 1 is associated with the upregulation of multiple genes. One specific upregulation event is characterized by a log2 fold change of approximately 3.13 and an adjusted p-value of 0.0357. Which protein is encoded by the gene corresponding to this specific upregulation event? | C-X-C motif chemokine 11 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06129","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Primate erythroparvovirus 1 is associated with the upregulation of multiple genes. One specific upregulation event is characterized by a log2 fold ch... | |
medium_divergent_branch_06130 | AP2M1 interacts with multiple genes. One of these interacting partners was identified in a study investigating signaling pathways and trafficking, where an interaction was observed between the partner and clathrin assembly protein complex 2 medium chain (AP50), a component of clathrin-coated pits. Which disease is asso... | schizophrenia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06130","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AP2M1 interacts with multiple genes. One of these interacting partners was identified in a study investigating signaling pathways and trafficking, wh... | |
medium_divergent_branch_06131 | CRTC2 interacts with multiple proteins. One of these interaction partners is described in a module consisting of the calcium-regulated phosphatase calcineurin and a Ser/Thr kinase, both of which associate with TORC2. Which protein is this interaction partner? | Serine/threonine-protein kinase SIK2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06131","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CRTC2 interacts with multiple proteins. One of these interaction partners is described in a module consisting of the calcium-regulated phosphatase ca... | |
medium_divergent_branch_06132 | TRAF2 interacts with multiple genes. One of these interaction partners is described in the following context: 'Furthermore, we provide evidence that this protein regulates CD40 signal transduction not only through its direct binding to CD40 but also indirectly via its association with TRAF2.' Based on this description,... | bone resorption disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06132","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRAF2 interacts with multiple genes. One of these interaction partners is described in the following context: 'Furthermore, we provide evidence that ... | |
medium_divergent_branch_06133 | SMAD6 interacts with multiple genes. One of these interactors is identified in a study as a deubiquitylating enzyme that also interacts with ALK3. Which disease is associated with this specific interactor gene via a biomarker relationship? | Moyamoya disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06133","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMAD6 interacts with multiple genes. One of these interactors is identified in a study as a deubiquitylating enzyme that also interacts with ALK3. Wh... | |
medium_divergent_branch_06134 | HAVCR1 interacts with multiple proteins. One of these interaction partners is a component of the ESCRT-0 complex involved in the intracellular trafficking of ubiquitinated cargos; this protein interacts with TIM-1 and is required for Dengue virus (DENV) infection. Which protein is encoded by the gene corresponding to t... | Signal transducing adapter molecule 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06134","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HAVCR1 interacts with multiple proteins. One of these interaction partners is a component of the ESCRT-0 complex involved in the intracellular traffi... | |
medium_divergent_branch_06135 | ADAR interacts with multiple proteins. One of these interaction partners is found in nuclear complexes that also contain RNA helicase A and Ku86/70. Which protein, encoded by the gene connected to ADAR via an interaction, is part of this specific complex? | Vigilin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06135","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ADAR interacts with multiple proteins. One of these interaction partners is found in nuclear complexes that also contain RNA helicase A and Ku86/70. ... | |
medium_divergent_branch_06136 | GGA1 interacts with multiple proteins. One interaction partner was identified because it belongs to a family of three structurally related proteins that were cloned from human cDNA libraries based on their ability to interact preferentially with the activated form of a specific ADP-ribosylation factor in two-hybrid ass... | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06136","source_qa_id":"medium_divergent_branch_03070","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"GGA1 interacts with multiple proteins. One interaction partner was identified because it belongs ... | |
medium_divergent_branch_06137 | HMGCR interacts with multiple proteins. One interaction is characterized by the formation of a reductase-Insig complex, which is recognized by a putative membrane-associated ubiquitin ligase (E3) that mediates the reductase ubiquitination reaction. Which protein, encoded by the gene involved in this specific interactio... | Insulin-induced gene 1 protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06137","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HMGCR interacts with multiple proteins. One interaction is characterized by the formation of a reductase-Insig complex, which is recognized by a puta... | |
medium_divergent_branch_06138 | SH3KBP1 interacts with multiple proteins. One interaction is supported by evidence listing effectors such as the phosphatidyl-inositol phosphatase synaptojanin 2B1, Arf GTPase-activating proteins ASAP1 and ARAP3, adaptor proteins Hip1R and STAP1, and the Rho exchange factor p115Rho GEF. Which cellular component is the ... | ruffle membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06138","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SH3KBP1 interacts with multiple proteins. One interaction is supported by evidence listing effectors such as the phosphatidyl-inositol phosphatase sy... | |
medium_divergent_branch_06139 | Glomerular filtration is associated with multiple anatomical structures. One of these structures is described as the layer of extracellular matrix lying between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell an... | basement membrane of epithelium | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06139","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Glomerular filtration is associated with multiple anatomical structures. One of these structures is described as the layer of extracellular matrix ly... | |
medium_divergent_branch_06141 | RHOBTB3 is associated with multiple molecular functions. One specific function is supported by evidence stating that biochemical analysis reveals the protein binds and hydrolyzes ATP rather than GTP. What is the parent molecular function (connected via 'is a') of this specific ATP-hydrolyzing function? | ribonucleoside triphosphate phosphatase activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06141","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RHOBTB3 is associated with multiple molecular functions. One specific function is supported by evidence stating that biochemical analysis reveals the... | |
medium_divergent_branch_06142 | MIR24-1 is associated with multiple biological processes. One specific association is supported by evidence showing that MiR-24 induces endothelial cell apoptosis, abolishes endothelial capillary network formation on Matrigel, and inhibits cell sprouting from endothelial spheroids. Which biological process is positivel... | endothelial cell apoptotic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06142","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR24-1 is associated with multiple biological processes. One specific association is supported by evidence showing that MiR-24 induces endothelial c... | |
medium_divergent_branch_06143 | Cone photoreceptor cells are anatomically connected to multiple structures via 'part of' relationships. One such connection is supported by evidence describing 'The layer within the retina where the photoreceptor cell receptor segments reside.' Which anatomy is connected to this specific layer through a 'part of' relat... | retinal neural layer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06143","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Cone photoreceptor cells are anatomically connected to multiple structures via 'part of' relationships. One such connection is supported by evidence ... | |
medium_divergent_branch_06145 | CD80 interacts with multiple proteins. One interaction is supported by evidence stating: 'We have identified, by site-directed mutagenesis of soluble forms of CD80 and CD86, residues in both the IgV and IgC domains that are important for CTLA4Ig and CD28Ig binding.' Which protein, connected to CD80 via this binding int... | Cytotoxic T-lymphocyte protein 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06145","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD80 interacts with multiple proteins. One interaction is supported by evidence stating: 'We have identified, by site-directed mutagenesis of soluble... | |
medium_divergent_branch_06146 | KAT2A interacts with multiple genes. One interaction is supported by evidence describing the use of mutagenesis, in vitro binding, protein-protein cross-linking, and chromatin immunoprecipitation assays to establish a role for the second activation subdomain (AD2) in STAGA recruitment, demonstrating that optimal bindin... | inflammatory disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06146","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KAT2A interacts with multiple genes. One interaction is supported by evidence describing the use of mutagenesis, in vitro binding, protein-protein cr... | |
medium_divergent_branch_06147 | MOB3C interacts with multiple proteins. One interaction is supported by evidence stating: 'We discovered a unique association between MOB3C and 7 of 10 protein subunits of the RNase P complex, an endonuclease that catalyzes tRNA 5' maturation.' Which protein, connected to MOB3C via this interaction, is the gene that en... | Ribonuclease P protein subunit p25 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06147","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MOB3C interacts with multiple proteins. One interaction is supported by evidence stating: 'We discovered a unique association between MOB3C and 7 of ... | |
medium_divergent_branch_06148 | CDK11A is reported to interact with multiple genes. One specific interaction was identified using a yeast two-hybrid screening strategy, which found eukaryotic initiation factor 3 p47 protein as an interacting partner of the caspase-processed C-terminal kinase domain of CDK11 (CDK11(p46)). Which disease is associated w... | intellectual developmental disorder, autosomal recessive 67 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06148","source_qa_id":"medium_divergent_branch_02412","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"CDK11A is reported to interact with multiple genes. One specific interaction was identified using... | |
medium_divergent_branch_06149 | ERLIN2 interacts with multiple genes. One of these interacting partners is part of a complex containing adenosine deaminase, erlin-2, stomatin, prohibitin, Thy-1 membrane glycoprotein, and caveolin-1, a formation validated by immunoblotting. Which disease is associated with this specific interacting gene? | neuroblastoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06149","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERLIN2 interacts with multiple genes. One of these interacting partners is part of a complex containing adenosine deaminase, erlin-2, stomatin, prohi... | |
medium_divergent_branch_06150 | ASXL1 is known to interact with multiple proteins. One specific interaction involves ASXL1 binding to forkhead transcription factors to regulate a subset of their target genes. Which protein, among those interacting with ASXL1, is described in this context as a forkhead transcription factor? | Forkhead box protein K2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06150","source_qa_id":"medium_divergent_branch_07140","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ASXL1 is known to interact with multiple proteins. One specific interaction involves ASXL1 bindin... | |
medium_divergent_branch_06151 | RBBP4 interacts with multiple genes. One of these interacting partners was shown to copurify with multiple constituents of the nucleosome remodeling and deacetylation (NuRD) complex, including CHD4, HDAC1, and RBBP4 itself. Which biological process is this specific interacting partner involved in? | negative regulation of transcription by RNA polymerase II | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06151","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RBBP4 interacts with multiple genes. One of these interacting partners was shown to copurify with multiple constituents of the nucleosome remodeling ... | |
medium_divergent_branch_06152 | MARK2 is associated with multiple biological processes via the 'involved in' relationship. One specific association is supported by evidence stating that prolonged expression of MARK2 leads to microtubule disruption, detachment of cells from the substratum, and cell death. Which biological process is the target of the ... | microtubule cytoskeleton organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06152","source_qa_id":"medium_divergent_branch_04409","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"MARK2 is associated with multiple biological processes via the 'involved in' relationship. One sp... | |
medium_divergent_branch_06153 | The gene CDYL is enriched in multiple cell types. One specific cell type shows a mean expression of 5.47 TPM, a z-score of 1.89, and a fold enrichment of 2.98 for CDYL. Which cell type is this, and what is its immediate parent category in the cell type hierarchy (i.e., what cell type is it a subtype of)? | granulocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06153","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CDYL is enriched in multiple cell types. One specific cell type shows a mean expression of 5.47 TPM, a z-score of 1.89, and a fold enrichmen... | |
medium_divergent_branch_06154 | ATXN3 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Subsequent immunoprecipitation assays confirmed that ATXN3 bound to this partner, mediating the deubiquitination and stabilization of this partner's protein levels.' Which disease is therapeutically linked to the gene invol... | thrombotic disease | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06154","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATXN3 interacts with multiple genes. One specific interaction is supported by evidence stating: 'Subsequent immunoprecipitation assays confirmed that... | |
medium_divergent_branch_06155 | MAPK8IP3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Yeast two-hybrid analysis and in vitro interaction studies reveal that SYD directly binds kinesin-I via the tetratricopeptide repeat (TPR) domain of kinesin light chain (KLC) with K(d) congruent with 200 nM.' Which protein, co... | Kinesin light chain 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06155","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAPK8IP3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Yeast two-hybrid analysis and in vitro interaction stud... | |
medium_divergent_branch_06157 | PARD6A interacts with multiple proteins. One specific interaction involves an E3 ubiquitin ligase, where evidence indicates that phosphorylation of Par6 controls its binding to this ligase during TGFbeta-dependent epithelial-mesenchymal transition in mammary gland epithelial cells. Which disease is associated with this... | lung cancer | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06157","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PARD6A interacts with multiple proteins. One specific interaction involves an E3 ubiquitin ligase, where evidence indicates that phosphorylation of P... | |
medium_divergent_branch_06158 | EPB41L2 interacts with multiple proteins. One interaction involves a protein that acts as a scaffold, where circEPB41L2 binds to the RRM1 domain of this protein and the E3 ubiquitin ligase TRIP12 to promote TRIP12-mediated polyubiquitylation and degradation of the protein. Which protein is this? | Polypyrimidine tract-binding protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06158","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EPB41L2 interacts with multiple proteins. One interaction involves a protein that acts as a scaffold, where circEPB41L2 binds to the RRM1 domain of t... | |
medium_divergent_branch_06159 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Human respirovirus 3 infection was found to upregulate multiple genes. One specific upregulated gene exhibited a log2 fold change of approximately 1.28 and an adjusted p-value of 0.0484. Which biological process is this specific gene involved in? | mitochondrial translation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06159","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Human respirovirus 3 infection was found to upregulate multiple genes. One s... | |
medium_divergent_branch_06160 | ARL2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Protein components were identified by mass spectroscopy and revealed the presence of four other proteins that include the tubulin folding cochaperone cofactor D and all three subunits of at least two protein phosphatase 2A (PP2A) ... | Tubulin-specific chaperone D | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06160","source_qa_id":"medium_divergent_branch_06136","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ARL2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Protein... | |
medium_divergent_branch_06161 | ACAD9 is reported to be located in multiple cellular components. One specific evidence statement notes that submitochondrial fractionation studies found native ACAD-9 to be associated with a particular structure. Which cellular component is this specific structure a part of? | mitochondrial envelope | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06161","source_qa_id":"medium_divergent_branch_07406","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ACAD9 is reported to be located in multiple cellular components. One specific evidence statement ... | |
medium_divergent_branch_06162 | PARD3 interacts with multiple proteins. One of these interaction partners is described in the literature as regulating cell polarity and cell-cell adhesion by binding to and co-localizing with PAR3 at tight junctions. Which protein is encoded by the gene corresponding to this specific interaction partner? | Apoptosis-stimulating of p53 protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06162","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PARD3 interacts with multiple proteins. One of these interaction partners is described in the literature as regulating cell polarity and cell-cell ad... | |
medium_divergent_branch_06163 | ZNF580 is associated with multiple biological processes. One association is supported by evidence showing that transient transfection of ZNF580 increased interleukin-8 (IL-8) levels by 3.01±0.05-fold and significantly enhanced the motility of human acute monocytic leukemia cells (THP-1). Which biological process, conne... | leukocyte chemotaxis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06163","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZNF580 is associated with multiple biological processes. One association is supported by evidence showing that transient transfection of ZNF580 incre... | |
medium_divergent_branch_06164 | Blood is classified as a type of two different anatomical entities. One of these entities is defined by evidence stating it is a fluid composed of blood plasma and erythrocytes. Which anatomical entity is blood a type of, based on this specific compositional evidence? | bodily fluid | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06164","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Blood is classified as a type of two different anatomical entities. One of these entities is defined by evidence stating it is a fluid composed of bl... | |
medium_divergent_branch_06166 | SMOC2 is associated with multiple biological processes. One association is supported by evidence that SMOC-2 adenovirus induced a 3-fold increase in the number of cells invading Matrigel plugs compared to a control. Which biological process is positively regulated by the process linked to this specific evidence? | endothelial cell chemotaxis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06166","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SMOC2 is associated with multiple biological processes. One association is supported by evidence that SMOC-2 adenovirus induced a 3-fold increase in ... | |
medium_divergent_branch_06167 | WNT4 is associated with multiple biological processes. One association is supported by evidence stating: 'Thus, WNT-4, a novel sex-determining gene, and DAX1 play a concerted role in both the control of female development and the prevention of testes formation.' Identify the biological process that is negatively regula... | male gonad development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06167","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WNT4 is associated with multiple biological processes. One association is supported by evidence stating: 'Thus, WNT-4, a novel sex-determining gene, ... | |
medium_divergent_branch_06168 | ARHGEF11 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Here we show that Plexin B2 associates directly with two members of a recently identified family of Dbl homology/pleckstrin homology containing guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and Leukemia-ass... | Plexin-B1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06168","source_qa_id":"medium_divergent_branch_05029","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"ARHGEF11 interacts with multiple proteins. One specific interaction is supported by evidence stat... | |
medium_divergent_branch_06169 | RABAC1 interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'Binding of this protein (and NDRG1-4) with PRA1 in vitro was confirmed by GST pull-down assay and immunoprecipitation, and colocalization was verified by confocal microscopy in HCT116 cells.' Which biological proc... | substantia nigra development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06169","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RABAC1 interacts with multiple genes. One of these interaction partners is supported by evidence stating: 'Binding of this protein (and NDRG1-4) with... | |
medium_divergent_branch_06170 | DNM1L interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we demonstrate that the protein encoded by the gene PRKN interacts with and subsequently ubiquitinates dynamin-related protein 1 (Drp1), for promoting its proteasome-dependent degradation.' Which protein is encoded by the g... | E3 ubiquitin-protein ligase parkin | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06170","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DNM1L interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we demonstrate that the protein encoded by the gene ... | |
medium_divergent_branch_06171 | The NPY2R protein enables multiple molecular functions. One specific function is supported by evidence describing the isolation of a human Y2 receptor cDNA using a 125I-PYY binding assay. What is the parent molecular function (via an 'is_a' relationship) of this specific function? | neuropeptide receptor activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06171","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The NPY2R protein enables multiple molecular functions. One specific function is supported by evidence describing the isolation of a human Y2 recepto... | |
medium_divergent_branch_06172 | GFRA2 interacts with multiple genes. One interaction is supported by the statement: 'Here we report that a ligand can bind to either GFRalpha-1 or GFRalpha-2, a novel receptor related to GFRalpha-1.' Which disease is associated with the gene identified in this statement via a biomarker relationship? | megacolon | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06172","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GFRA2 interacts with multiple genes. One interaction is supported by the statement: 'Here we report that a ligand can bind to either GFRalpha-1 or GF... | |
medium_divergent_branch_06173 | PTK2B interacts with multiple proteins. One specific interaction is supported by evidence stating: 'PRAP contains a coiled-coil domain, a pleckstrin homology domain, and a SH3 domain; the SH3 domain binds to the proline-rich domain of Pyk2/RAFTK.' Which protein corresponds to the gene linked to PTK2B by this specific i... | Src kinase-associated phosphoprotein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06173","source_qa_id":"medium_divergent_branch_01367","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PTK2B interacts with multiple proteins. One specific interaction is supported by evidence stating... | |
medium_divergent_branch_06174 | IFNAR1 interacts with multiple proteins. One specific interaction is characterized by the following evidence: 'Previous work showed that a point mutation in the Src homology 2 (SH2) domain prevents this protein from binding to phosphotyrosine 466 of the IFNAR1 subunit of the activated receptor.' What is the full name o... | Signal transducer and activator of transcription 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06174","source_qa_id":"medium_divergent_branch_00478","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"IFNAR1 interacts with multiple proteins. One specific interaction is characterized by the followi... | |
medium_divergent_branch_06175 | HCFC1 interacts with multiple proteins. One specific interaction is described by the following evidence: 'We show here that separate regions of HCF-1 critical for its role in cell proliferation associate with the Sin3 histone deacetylase (HDAC) and a previously uncharacterized human trithorax-related histone methyltran... | Histone-lysine N-methyltransferase SETD1A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06175","source_qa_id":"medium_divergent_branch_06542","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"HCFC1 interacts with multiple proteins. One specific interaction is described by the following ev... | |
medium_divergent_branch_06177 | The gene TNFAIP3 interacts with multiple partners. One specific interaction is supported by evidence stating: 'Here we report the cloning and characterization of a previously unknown protein that binds to the COOH-terminal zinc finger domain of A20.' Which protein is encoded by the gene that corresponds to this specifi... | TNFAIP3-interacting protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06177","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene TNFAIP3 interacts with multiple partners. One specific interaction is supported by evidence stating: 'Here we report the cloning and charact... | |
medium_divergent_branch_06178 | IQGAP1 is associated with multiple biological processes. One association is supported by evidence stating: 'Our data disclose that IQGAP1 is phosphorylated at multiple sites in intact cells and that phosphorylation of IQGAP1 will alter its ability to regulate the cytoskeleton of neuronal cells.' Which biological proces... | actin cytoskeleton organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06178","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IQGAP1 is associated with multiple biological processes. One association is supported by evidence stating: 'Our data disclose that IQGAP1 is phosphor... | |
medium_divergent_branch_06179 | ADAM17 interacts with multiple genes. One of these interaction partners is identified by mechanistic studies showing that it binds directly to E3 ubiquitin ligase tripartite motif-containing protein 47. Which biological process is this specific interaction partner involved in? | protein ubiquitination | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06179","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ADAM17 interacts with multiple genes. One of these interaction partners is identified by mechanistic studies showing that it binds directly to E3 ubi... | |
medium_divergent_branch_06180 | NANOG interacts with multiple proteins. One of these interaction partners is part of a sub-network associated with the establishment and maintenance of pluripotency, which includes OCT4, PATZ1, and the developmental regulator DPPA4. Evidence indicates that this specific partner was found to independently interact with ... | Polycomb group RING finger protein 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06180","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NANOG interacts with multiple proteins. One of these interaction partners is part of a sub-network associated with the establishment and maintenance ... | |
medium_divergent_branch_06181 | BCAR1 interacts with multiple proteins. One specific interaction involves a partner where disruption of its binding to CAS blocks downstream effectors of the actin cytoskeleton and focal adhesion assembly, inhibits cell migration, and disrupts survival signals leading to apoptosis. Which disease is associated with this... | autism spectrum disorder | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06181","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BCAR1 interacts with multiple proteins. One specific interaction involves a partner where disruption of its binding to CAS blocks downstream effector... | |
medium_divergent_branch_06182 | GBP7 is associated with multiple biological processes. One association is supported by evidence that overexpression of GBP7 facilitates Influenza A virus (IAV) replication by suppressing the expression of type I interferon (IFN), type III IFN, and proinflammatory cytokines. Which biological process, connected to GBP7, ... | cytokine production | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06182","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GBP7 is associated with multiple biological processes. One association is supported by evidence that overexpression of GBP7 facilitates Influenza A v... | |
medium_divergent_branch_06183 | West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.047 and an adjusted p-value of 0.0121. Which protein does that selected gene encode? | P2Y purinoceptor 14 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06183","source_qa_id":"medium_divergent_branch_07382","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log... | |
medium_divergent_branch_06184 | CAMKK2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'In this study, our results illustrated that the protein encoded by PARK7 can directly interact with CaMKKβ.' Which disease is associated with the gene identified by this interaction through genomic alterations? | autosomal recessive early-onset Parkinson disease 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06184","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CAMKK2 interacts with multiple genes. One specific interaction is supported by evidence stating: 'In this study, our results illustrated that the pro... | |
medium_divergent_branch_06185 | LYN interacts with multiple genes. One interaction is supported by evidence stating: 'Interaction between a specific adaptor protein and src family kinases, Fyn, Hck and LYN, was detected during monocytes/macrophage-differentiation of U937 cells.' Which cellular component is this interaction partner located in? | plasma membrane | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06185","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LYN interacts with multiple genes. One interaction is supported by evidence stating: 'Interaction between a specific adaptor protein and src family k... | |
medium_divergent_branch_06187 | UBA7 interacts with multiple genes. One of these interactions is supported by evidence stating: 'The C-terminal ubiquitin fold domain (UFD) of Ube1L was required for transfer of ISG15 to a specific E2 conjugating enzyme and for binding of Ube1L to that enzyme.' Which protein is encoded by the gene connected to UBA7 via... | Ubiquitin/ISG15-conjugating enzyme E2 L6 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06187","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UBA7 interacts with multiple genes. One of these interactions is supported by evidence stating: 'The C-terminal ubiquitin fold domain (UFD) of Ube1L ... | |
medium_divergent_branch_06188 | The glomerular endothelium is classified under multiple anatomical categories. One classification describes the entity as an epithelial tissue that covers the internal surfaces of the glomerulus. Which anatomical structure is the parent of this specific epithelial tissue category via a 'part of' relationship? | renal glomerulus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06188","source_qa_id":"medium_divergent_branch_00512","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The glomerular endothelium is classified under multiple anatomical categories. One classification... | |
medium_divergent_branch_06189 | PPP4R2 interacts with multiple proteins. Experimental evidence indicates that two proteins specifically co-purify with Flag-epitope-tagged R2 expressed in HEK-293 cells: Gemin3 and the protein of interest. Which protein is the one identified in this co-purification experiment? | Gem-associated protein 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06189","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PPP4R2 interacts with multiple proteins. Experimental evidence indicates that two proteins specifically co-purify with Flag-epitope-tagged R2 express... | |
medium_divergent_branch_06190 | HDAC1 is associated with multiple biological processes. One association is supported by evidence stating: 'Four copies of HDAC1 are positioned at the periphery with outward-facing active sites suggesting that the complex may target multiple nucleosomes implying a processive deacetylase function.' Which biological proce... | cellular component organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06190","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HDAC1 is associated with multiple biological processes. One association is supported by evidence stating: 'Four copies of HDAC1 are positioned at the... | |
medium_divergent_branch_06191 | Levorphanol interacts with multiple substances. Evidence indicates that preexposure to a 5 mg/kg dose of one such interacting substance blocked both morphine-induced and that substance-induced conditioned taste aversions (CTAs). Which disease is the interacting substance indicated for? | trigeminal neuralgia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06191","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Levorphanol interacts with multiple substances. Evidence indicates that preexposure to a 5 mg/kg dose of one such interacting substance blocked both ... | |
medium_divergent_branch_06193 | FOXP2 is associated with multiple molecular functions via the 'enables' relationship. One such function is supported by evidence stating: 'Previous studies have shown that the transcriptional activity of FOXP1/2/4 is regulated by homo- and heterodimerization.' Identify the parent molecular function (via the 'is_a' rela... | binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06193","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXP2 is associated with multiple molecular functions via the 'enables' relationship. One such function is supported by evidence stating: 'Previous s... | |
medium_divergent_branch_06194 | RNF20 interacts with multiple proteins. One specific interaction partner binds to RNF20 via its C-terminal coiled-coil region and enhances RNF20's E3 ligase activity for H2B ubiquitination. Which protein is encoded by the gene corresponding to this specific interaction partner? | WW domain-containing adapter protein with coiled-coil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06194","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF20 interacts with multiple proteins. One specific interaction partner binds to RNF20 via its C-terminal coiled-coil region and enhances RNF20's E3... | |
medium_divergent_branch_06195 | CSF2RB interacts with multiple proteins. One interaction is supported by evidence stating: 'We have investigated the potential of an adaptor protein to integrate IL-3 signalling pathways and demonstrate that this protein associates with the beta subunits of the human (betac) and murine (Aic2A) IL-3 receptors, SHIP and ... | malignant pancreatic neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06195","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CSF2RB interacts with multiple proteins. One interaction is supported by evidence stating: 'We have investigated the potential of an adaptor protein ... | |
medium_divergent_branch_06196 | INTS6 interacts with multiple proteins. One specific interaction was investigated for its functional significance after being observed in a two-hybrid screen where INTS6 served as the bait. Which protein, encoded by the gene connected to INTS6 via this specific interaction, is the subject of this report? | DNA replication licensing factor MCM7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06196","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"INTS6 interacts with multiple proteins. One specific interaction was investigated for its functional significance after being observed in a two-hybri... | |
medium_divergent_branch_06197 | PDPK1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Treatment of cells with growth factor induced recruitment of PDK1 to the Ser386-phosphorylated hydrophobic motif and phosphorylation of the target protein at Ser227.' Which protein, encoded by the gene involved in this specific i... | Ribosomal protein S6 kinase alpha-3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06197","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PDPK1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Treatment of cells with growth factor induced recruitment ... | |
medium_divergent_branch_06198 | PFN1 interacts with multiple proteins. One of these interaction partners is described in a study stating: 'In contrast, phosphorylation had no significant effect on this protein's oligomerization or its interaction with its known ligands profilin, vinculin, and zyxin.' What is the full name of the protein encoded by th... | Vasodilator-stimulated phosphoprotein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06198","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PFN1 interacts with multiple proteins. One of these interaction partners is described in a study stating: 'In contrast, phosphorylation had no signif... | |
medium_divergent_branch_06199 | PRAME interacts with multiple genes. One of these interaction partners is identified in a study that mined the PRAME interactome to identify specific interactions with human orthologues of the ancient EKC/KEOPS complex. Which disease is associated with this specific interaction partner? | Galloway-Mowat syndrome 2, X-linked | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06199","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRAME interacts with multiple genes. One of these interaction partners is identified in a study that mined the PRAME interactome to identify specific... | |
medium_divergent_branch_06200 | CRKL interacts with multiple proteins. One interaction is supported by evidence stating that a specific E3 ubiquitin ligase constitutively binds Grb2 and becomes associated with Crk-L upon TCR stimulation. Which protein product is encoded by the gene corresponding to this specific interacting partner? | E3 ubiquitin-protein ligase CBL-B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06200","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CRKL interacts with multiple proteins. One interaction is supported by evidence stating that a specific E3 ubiquitin ligase constitutively binds Grb2... | |
medium_divergent_branch_06201 | CHEK1 interacts with multiple proteins. One interaction partner is identified in a study reporting unknown interaction partners in T cells, specifically listing Raptor, CREB1, RUNX1, SATB1, Ikaros, and Helios alongside the partner. Which protein is this interaction partner, and what protein does the gene encoding this ... | Nuclear factor of activated T-cells, cytoplasmic 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06201","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CHEK1 interacts with multiple proteins. One interaction partner is identified in a study reporting unknown interaction partners in T cells, specifica... | |
medium_divergent_branch_06202 | mmu-miR-139-5p regulates more than one cell type. Evidence for one of these regulatory connections states: 'In this study, we found that miR-139-5p negatively regulated the proliferation of hematopoietic stem cells and progenitor cells and that downregulation of miR-139-5p expression was associated with hematopoietic m... | angioblastic mesenchymal cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06202","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"mmu-miR-139-5p regulates more than one cell type. Evidence for one of these regulatory connections states: 'In this study, we found that miR-139-5p n... | |
medium_divergent_branch_06203 | FOXO3 interacts with multiple proteins. One of these interaction partners is an E3 ubiquitin ligase subunit that binds preferentially to deacetylated FOXO3. Which protein is encoded by the gene corresponding to this interaction partner? | S-phase kinase-associated protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06203","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXO3 interacts with multiple proteins. One of these interaction partners is an E3 ubiquitin ligase subunit that binds preferentially to deacetylated... | |
medium_divergent_branch_06204 | The protein CIB1 is associated with multiple biological processes. One association is supported by evidence stating: 'Here, we show that overexpression of CIB1 inhibits T47D cell proliferation.' Which biological process, connected to the process supported by this evidence via an 'is a' relationship, is the correct targ... | regulation of cellular process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06204","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein CIB1 is associated with multiple biological processes. One association is supported by evidence stating: 'Here, we show that overexpressi... | |
medium_divergent_branch_06205 | BIN3 is associated with multiple biological processes. One association is supported by evidence stating: 'These findings suggest that hob3+ and BIN3 regulate F-actin localization.' Which biological process, connected to the process implicated by this evidence via an 'is a' relationship, is the correct answer? | macromolecule localization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06205","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BIN3 is associated with multiple biological processes. One association is supported by evidence stating: 'These findings suggest that hob3+ and BIN3 ... | |
medium_divergent_branch_06206 | WDHD1 interacts with multiple proteins. One of these interaction partners is described by the following evidence: 'Mechanistically, And-1 interacts with a protein encoded by the gene RBBP8 and regulates its recruitment to DNA damage sites.' Which protein is encoded by the gene corresponding to this specific interaction... | DNA endonuclease RBBP8 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06206","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WDHD1 interacts with multiple proteins. One of these interaction partners is described by the following evidence: 'Mechanistically, And-1 interacts w... | |
medium_divergent_branch_06208 | WRAP53 interacts with multiple proteins. One of these interaction partners is known to directly interact with WRAP53β, a protein that recruits RNF8 to DNA double-strand breaks (DSBs). Furthermore, WRAP53β enhances the association of this interaction partner with RNF8. Which protein is connected to the gene WRAP53 throu... | ATP-dependent DNA helicase Q4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06208","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WRAP53 interacts with multiple proteins. One of these interaction partners is known to directly interact with WRAP53β, a protein that recruits RNF8 t... | |
medium_divergent_branch_06209 | MSH4 interacts with multiple proteins. One specific interaction is characterized by the formation of a heterodimeric complex between MSH4 and the partner protein, which plays a critical role in meiotic processes. Which disease is associated with this specific partner protein through genomic alterations? | premature ovarian failure 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06209","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MSH4 interacts with multiple proteins. One specific interaction is characterized by the formation of a heterodimeric complex between MSH4 and the par... | |
medium_divergent_branch_06210 | ANAPC16 interacts with multiple genes. One specific interaction is supported by structural evidence showing that APC16 binds asymmetrically to the symmetric APC3 dimer and recruits a specific partner gene to APC3. Which disease is associated with the gene identified in this specific interaction? | Ferguson-Bonni neurodevelopmental syndrome | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06210","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ANAPC16 interacts with multiple genes. One specific interaction is supported by structural evidence showing that APC16 binds asymmetrically to the sy... | |
medium_divergent_branch_06211 | CCL3 is associated with multiple biological processes. One of these associations is supported by evidence that CCL3 represses mineralization and osteocalcin production in primary human bone marrow stromal cells and HS27A cells. Which cell type is linked to this specific biological process via the 'enabled by cell' rela... | osteochondral skeletal stem cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06211","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CCL3 is associated with multiple biological processes. One of these associations is supported by evidence that CCL3 represses mineralization and oste... | |
medium_divergent_branch_06212 | MORC2 interacts with multiple proteins. One of these interaction partners is known to be involved in a pathway where DNA-damaging chemotherapeutic agents and ionizing radiation stimulate the acetylation of MORC2 at lysine 767 (K767Ac) by enhancing the physical interaction between MORC2 and this partner. Which protein, ... | RNA cytidine acetyltransferase | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06212","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MORC2 interacts with multiple proteins. One of these interaction partners is known to be involved in a pathway where DNA-damaging chemotherapeutic ag... | |
medium_divergent_branch_06213 | The patella is classified as a type of anatomy. One such classification is supported by evidence describing the entity as a large sesamoid bone found in the distal femur/proximal tibial region of the hindlimb of tetrapods, serving as the attachment site for proximal hindlimb tendons. Which anatomical structure is the p... | appendicular skeleton | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06213","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The patella is classified as a type of anatomy. One such classification is supported by evidence describing the entity as a large sesamoid bone found... |
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