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medium_divergent_branch_06214 | EIF4EBP1 interacts with multiple proteins. One interaction partner is characterized by the following evidence: 'Here, we show that a functional TOS motif is required for 4E-BP1 to bind to this protein (a recently identified mTOR-interacting protein), for 4E-BP1 to be efficiently phosphorylated in vitro by the mTOR/this... | gamma-delta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06214","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EIF4EBP1 interacts with multiple proteins. One interaction partner is characterized by the following evidence: 'Here, we show that a functional TOS m... | |
medium_divergent_branch_06215 | SLC11A2 interacts with multiple genes. One of these interaction partners is part of a complex with Ndfip2 and another protein, both of which are WW domain-interacting proteins previously proposed to have roles in protein trafficking. Which cell type is enriched for the gene corresponding to this other WW domain-interac... | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06215","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SLC11A2 interacts with multiple genes. One of these interaction partners is part of a complex with Ndfip2 and another protein, both of which are WW d... | |
medium_divergent_branch_06216 | DDX6 interacts with multiple proteins. One interaction partner is supported by evidence stating: 'We also determined the crystal structure of LSM14 bound to the C-terminal RecA-like domain of DDX6.' Which protein, connected to DDX6 via an interaction, is encoded by the gene identified in this structural context? | Eukaryotic translation initiation factor 4E transporter | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06216","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"DDX6 interacts with multiple proteins. One interaction partner is supported by evidence stating: 'We also determined the crystal structure of LSM14 b... | |
medium_divergent_branch_06217 | NEDD4 is associated with multiple biological processes. One association is supported by evidence stating that neural differentiation induced not only the down-regulation of NEDD4 but also the localization of the protein to both the cytoplasm and neurites. Which biological process, connected to the process supported by ... | plasma membrane bounded cell projection organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06217","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NEDD4 is associated with multiple biological processes. One association is supported by evidence stating that neural differentiation induced not only... | |
medium_divergent_branch_06218 | The gene NQO1 interacts with multiple other genes. One of these interactions is characterized by evidence stating: 'We demonstrate that NQO1 directly binds to the oxygen-dependent domain of HIF-1α and inhibits the proteasome-mediated degradation of HIF-1α by preventing PHDs from interacting with HIF-1α.' Which protein ... | Hypoxia-inducible factor 1-alpha | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06218","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NQO1 interacts with multiple other genes. One of these interactions is characterized by evidence stating: 'We demonstrate that NQO1 directly... | |
medium_divergent_branch_06219 | The gene IKBKB interacts with multiple other genes. One specific interaction partner is supported by evidence showing that its protein product, a signal-transducing adaptor protein, particularly via its Src homology 2-like domain, binds to both MyD88 and IkappaB kinase (IKK)-alphabeta, but not to TNFR-associated factor... | Signal-transducing adaptor protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06219","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene IKBKB interacts with multiple other genes. One specific interaction partner is supported by evidence showing that its protein product, a sig... | |
medium_divergent_branch_06221 | MIR1-1 is associated with multiple biological processes via the 'involved in' relationship. One such association is supported by evidence stating: 'Previous studies demonstrated that microRNA-1 (miR-1) could promote cardiac differentiation from mouse and human embryonic stem (ES) cells.' Identify the biological process... | cardiac muscle cell differentiation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06221","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR1-1 is associated with multiple biological processes via the 'involved in' relationship. One such association is supported by evidence stating: 'P... | |
medium_divergent_branch_06222 | EHMT2 interacts with multiple proteins. One of these interaction partners contains a histone H3K9-like mimic that is methylated by G9a and GLP and binds UHRF1 more avidly than H3K9me2/3. Which protein is this interaction partner? | DNA ligase 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06222","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EHMT2 interacts with multiple proteins. One of these interaction partners contains a histone H3K9-like mimic that is methylated by G9a and GLP and bi... | |
medium_divergent_branch_06223 | BCL2A1 interacts with multiple proteins. Evidence for one of these interactions states: 'We find that Bfl-1 associates with both full-length [protein] and truncated (t)[protein], via the [protein] BH3 domain.' Which protein, connected to BCL2A1 through an interaction, is described by this evidence? Provide the name of ... | BH3-interacting domain death agonist | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06223","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"BCL2A1 interacts with multiple proteins. Evidence for one of these interactions states: 'We find that Bfl-1 associates with both full-length [protein... | |
medium_divergent_branch_06224 | The optic tract is anatomically connected to a specific structure via a 'part of' relationship. Evidence for this connection describes the optic tract as a predominantly white matter structure located in the diencephalon, consisting of retinal ganglion cell axons that have passed through the optic chiasm. It extends fr... | white matter of forebrain | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06224","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The optic tract is anatomically connected to a specific structure via a 'part of' relationship. Evidence for this connection describes the optic trac... | |
medium_divergent_branch_06226 | TMEM33 interacts with multiple proteins. One of these interaction partners is reported to co-assemble with TMEM43, ENDOD1, TMEM33, and TMED1 to form a complex that modulates innate immune signaling through the cGAS-STING pathway. Which protein corresponds to this interaction partner? | E3 ubiquitin-protein ligase RNF26 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06226","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TMEM33 interacts with multiple proteins. One of these interaction partners is reported to co-assemble with TMEM43, ENDOD1, TMEM33, and TMED1 to form ... | |
medium_divergent_branch_06227 | RNF168 interacts with multiple proteins. One specific interaction involves a complex containing LSD1, RNF168, and a DNA damage response protein, which are reported to interact directly. Which disease is associated with the gene encoding this DNA damage response protein through genomic alterations? | lupus vulgaris | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06227","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF168 interacts with multiple proteins. One specific interaction involves a complex containing LSD1, RNF168, and a DNA damage response protein, whic... | |
medium_divergent_branch_06228 | E2F1 interacts with multiple proteins. One of these interaction partners is described in evidence stating that Necdin and MAGE-G1 interact with this transcription factor via its transactivation domain, repress its dependent transcription, and antagonize its induced apoptosis in N1E-115 neuroblastoma cells. Which protei... | Non-structural maintenance of chromosomes element 3 homolog | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06228","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"E2F1 interacts with multiple proteins. One of these interaction partners is described in evidence stating that Necdin and MAGE-G1 interact with this ... | |
medium_divergent_branch_06229 | FKBP1A interacts with multiple genes. One of these interaction partners is efficiently extracted from the terminal cisternae of skeletal muscle using glutathione S-transferase (GST)-FKBP12 affinity chromatography, with approximately 42% of the solubilized protein recovered. Another fraction (approximately 32%) of this ... | congenital myopathy 20 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06229","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FKBP1A interacts with multiple genes. One of these interaction partners is efficiently extracted from the terminal cisternae of skeletal muscle using... | |
medium_divergent_branch_06230 | ATRX interacts with multiple proteins. One interaction is supported by evidence stating: 'We found the protein in question to associate with ATRX, but also HP1 and NAP1, suggesting a role in chromatin maintenance.' Which protein, connected to ATRX via this specific interaction, is encoded by the gene in question? | Coiled-coil domain-containing protein 71 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06230","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ATRX interacts with multiple proteins. One interaction is supported by evidence stating: 'We found the protein in question to associate with ATRX, bu... | |
medium_divergent_branch_06231 | The gene HTR7 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'Here, we report the structures of the serotonin receptors 5-HT4, 5-HT6, and 5-HT7 with Gs'. Which molecular function, linked to the function supported by this evidenc... | G protein-coupled amine receptor activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06231","source_qa_id":"medium_divergent_branch_05275","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"The gene HTR7 is associated with multiple molecular functions via the 'enables' relationship. One... | |
medium_divergent_branch_06232 | Human gammaherpesvirus 4 downregulates multiple genes. One such gene exhibits a log2 fold change of -1.065 and an adjusted p-value of 0.04433 in gamma delta T-lymphocytes. Which biological process is this specific gene involved in? | proteasome-mediated ubiquitin-dependent protein catabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06232","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Human gammaherpesvirus 4 downregulates multiple genes. One such gene exhibits a log2 fold change of -1.065 and an adjusted p-value of 0.04433 in gamm... | |
medium_divergent_branch_06233 | HIC1 interacts with multiple genes. One specific interaction is supported by evidence stating that Co-immunoprecipitation assays in WI38 fibroblasts and in BRG1-/- SW13 cells demonstrated that endogenous HIC1 and the interacting partner protein associate in a BRG1-dependent manner. Which disease is associated with this... | Burkitt lymphoma | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06233","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HIC1 interacts with multiple genes. One specific interaction is supported by evidence stating that Co-immunoprecipitation assays in WI38 fibroblasts ... | |
medium_divergent_branch_06234 | UBXN7 is known to interact with multiple proteins. One specific interaction is described by the following evidence: 'We found that UBXN7, a member of the UBA-UBX family, directly interacts with the RING domain of a protein or its related E3 RNF165/ARK2C that shares high sequence homology with this protein.' Based on th... | E3 ubiquitin-protein ligase Arkadia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06234","source_qa_id":"medium_divergent_branch_01335","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"UBXN7 is known to interact with multiple proteins. One specific interaction is described by the f... | |
medium_divergent_branch_06235 | The gene NF1 interacts with multiple partners. One specific interaction is supported by evidence stating: 'In cell-free systems, purified recombinant NF1-GRD mutants showed an inhibitory effect on the association of Ras.guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) with Raf at several times lower concentrations tha... | basophil | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06235","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NF1 interacts with multiple partners. One specific interaction is supported by evidence stating: 'In cell-free systems, purified recombinant... | |
medium_divergent_branch_06236 | Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showed a log2 fold change of -1.060 and an adjusted p-value of 0.0446. Which protein does that selected gene encode? | SERTA domain-containing protein 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06236","source_qa_id":"medium_divergent_branch_01548","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Human respirovirus 3 downregulates several genes. In the recorded experiment, one branch showe... | |
medium_divergent_branch_06237 | KIR3DL2 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'We report in this article that KIR3DL2 and KIR2DS4 and the nonclassical Ag HLA-F, expressed as a free form devoid of peptide, physically and functionally interact.' Given t... | MHC protein binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06237","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KIR3DL2 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by evidence stating: 'W... | |
medium_divergent_branch_06238 | The gene KLRK1 is enriched in multiple cell types. One specific cell type exhibits a mean expression of 366.85 TPM, a z-score of 1.69, and a fold enrichment of 6.40 for this gene. Which cell type is the developmental precursor to the cell type characterized by these expression statistics? | pro-NK cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06238","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene KLRK1 is enriched in multiple cell types. One specific cell type exhibits a mean expression of 366.85 TPM, a z-score of 1.69, and a fold enr... | |
medium_divergent_branch_06239 | TWIST1 is associated with multiple biological processes. One association is supported by evidence stating that persistent TWIST1 expression in remodeling valves leads to increased valve cell proliferation, increased expression of Tbx20, and increased extracellular matrix (ECM) gene expression, which are characteristics... | heart valve development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06239","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TWIST1 is associated with multiple biological processes. One association is supported by evidence stating that persistent TWIST1 expression in remode... | |
medium_divergent_branch_06240 | INCA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Several novel proteins (INCA1, KARCA1, and PROCA1) as well as the known proteins GPS2 (G-protein pathway suppressor 2), Ku70, receptor for activated protein kinase C1/guanine nucleotide-binding protein beta-2-like-1, and mRNA-bin... | Cyclin-A1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06240","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"INCA1 interacts with multiple proteins. One interaction is supported by evidence stating: 'Several novel proteins (INCA1, KARCA1, and PROCA1) as well... | |
medium_divergent_branch_06241 | Clusterin (CLU) interacts with multiple proteins. One specific interaction is supported by evidence stating that 'Co-immunoprecipitation (co-IP) and confocal microscopy experiments confirmed the direct interaction between CLU and a specific chaperone protein under ER stress condition.' Which protein, encoded by the gen... | Endoplasmic reticulum chaperone BiP | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06241","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Clusterin (CLU) interacts with multiple proteins. One specific interaction is supported by evidence stating that 'Co-immunoprecipitation (co-IP) and ... | |
medium_divergent_branch_06242 | LDLR interacts with multiple proteins. One interaction is supported by the statement: 'Here, we show that a specific protein binds to LDL receptors as well.' Which protein, encoded by the gene connected to LDLR via this specific interaction, is the subject of the query? | Alpha-2-macroglobulin receptor-associated protein | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06242","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"LDLR interacts with multiple proteins. One interaction is supported by the statement: 'Here, we show that a specific protein binds to LDL receptors a... | |
medium_divergent_branch_06243 | APAF1 interacts with multiple proteins. One specific interaction involves a protein that binds to Apaf-1, an event that may trigger the activation of caspase-3, leading to apoptosis. Which gene encodes this interacting protein? | Cytochrome c | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06243","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"APAF1 interacts with multiple proteins. One specific interaction involves a protein that binds to Apaf-1, an event that may trigger the activation of... | |
medium_divergent_branch_06244 | The gene ASF1A interacts with multiple histone H3 variants. One specific interaction is supported by evidence stating: 'Newly synthesized histones H3-H4 first bind histone chaperone Asf1 and are then transferred to other chaperones for nucleosome assembly.' Which protein is encoded by the gene that interacts with ASF1A... | Histone H3.3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06244","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene ASF1A interacts with multiple histone H3 variants. One specific interaction is supported by evidence stating: 'Newly synthesized histones H3... | |
medium_divergent_branch_06245 | FLT3 interacts with multiple proteins. One interaction is characterized by the following evidence: 'The results show that upon ligand stimulation a protein stably associates with Flt3 through multiple phosphotyrosine residues in Flt3.' Which disease is associated with the gene involved in this specific interaction via ... | intestinal volvulus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06245","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FLT3 interacts with multiple proteins. One interaction is characterized by the following evidence: 'The results show that upon ligand stimulation a p... | |
medium_divergent_branch_06246 | FHL3 interacts with multiple genes. One interaction is supported by evidence stating: 'We show here that a Kruppel-like transcription factor also recruits the four and a half LIM domain protein FHL3.' Which biological process is the gene involved in this specific interaction connected to via the 'involved in' relations... | hemopoiesis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06246","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FHL3 interacts with multiple genes. One interaction is supported by evidence stating: 'We show here that a Kruppel-like transcription factor also rec... | |
medium_divergent_branch_06247 | TRIM23 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we report crystal structures of the TRIM23 RING domain in isolation and in complex with an E2-ubiquitin conjugate.' Which protein, connected to TRIM23 via this interaction, is the subject of the 'encodes' relation in the f... | Ubiquitin-conjugating enzyme E2 D3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06247","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TRIM23 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we report crystal structures of the TRIM23 RING dom... | |
medium_divergent_branch_06248 | The protein ACTB is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence stating: 'Using two-photon photoactivation of green fluorescent protein fused to beta-actin, we found that a dynamic pool of F-actin at the tip of the spine quickly tread... | synapse | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06248","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein ACTB is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence... | |
medium_divergent_branch_06249 | SMARCA4 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, we show that a [protein complex partner]-BRG1 complex regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex.' Which cellular component is ... | kinetochore | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06249","source_qa_id":"medium_divergent_branch_05352","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"SMARCA4 interacts with multiple genes. One interaction is supported by evidence stating: 'Here, w... | |
medium_divergent_branch_06251 | The gene PCMTD2 is enriched in multiple immune cell types. One specific cell type shows a mean expression of 17.52 TPM, a z-score of 1.64, and a fold enrichment of 2.11. Which broader cell lineage is this specific cell type a subtype of? | mature T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06251","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PCMTD2 is enriched in multiple immune cell types. One specific cell type shows a mean expression of 17.52 TPM, a z-score of 1.64, and a fold... | |
medium_divergent_branch_06252 | CTNNA1 interacts with multiple genes. One of these interaction partners was identified in an experiment where alpha-Catenin was isolated as a binding protein of the partner. Which biological process is this specific interaction partner involved in? | proteasome-mediated ubiquitin-dependent protein catabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06252","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CTNNA1 interacts with multiple genes. One of these interaction partners was identified in an experiment where alpha-Catenin was isolated as a binding... | |
medium_divergent_branch_06253 | SYN1 interacts with multiple proteins. One interaction is supported by evidence stating that 'quantitative yeast two-hybrid protein-protein binding assays demonstrated pairwise strong interactions between all synapsins.' Which protein product is encoded by the gene corresponding to this specific interacting partner? | Synapsin-2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06253","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SYN1 interacts with multiple proteins. One interaction is supported by evidence stating that 'quantitative yeast two-hybrid protein-protein binding a... | |
medium_divergent_branch_06254 | IGF1R interacts with multiple genes. One of these interactions is supported by evidence that the hSOCS-1 protein interacted strongly with IGF-IR in a two-hybrid assay. Which cellular component is the gene corresponding to this specific interaction located in? | cytoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06254","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"IGF1R interacts with multiple genes. One of these interactions is supported by evidence that the hSOCS-1 protein interacted strongly with IGF-IR in a... | |
medium_divergent_branch_06255 | GRHL2 is associated with multiple biological processes. One specific association is supported by evidence showing that immortalized keratinocytes with the p.Ile482Lys mutation exhibit altered cell morphology, impaired tight junctions, adhesion defects, and cytoplasmic translocation of GRHL2. Which cellular component is... | bicellular tight junction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06255","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GRHL2 is associated with multiple biological processes. One specific association is supported by evidence showing that immortalized keratinocytes wit... | |
medium_divergent_branch_06256 | West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.053 and an adjusted p-value of 0.0101. Which protein does that selected gene encode? | Calcium load-activated calcium channel | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06256","source_qa_id":"medium_divergent_branch_04149","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"West Nile virus upregulates several genes. In the recorded experiment, one branch showed a log... | |
medium_divergent_branch_06257 | The gene POLB interacts with multiple partners. One specific interaction is supported by evidence stating: 'All of these proteins interact with polbetaDelta in vitro and in vivo.' Which disease is associated with this specific interacting partner via a biomarker relationship? | idiopathic pulmonary fibrosis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06257","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene POLB interacts with multiple partners. One specific interaction is supported by evidence stating: 'All of these proteins interact with polbe... | |
medium_divergent_branch_06258 | FOXO4 interacts with multiple proteins. One of these interaction partners is reported to bind to and phosphorylate FOXO1, FOXO3a, and FOXO4 on multiple residues. Which protein corresponds to this interaction partner? | Serine/threonine-protein kinase NLK | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06258","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FOXO4 interacts with multiple proteins. One of these interaction partners is reported to bind to and phosphorylate FOXO1, FOXO3a, and FOXO4 on multip... | |
medium_divergent_branch_06259 | Synaptopodin (SYNPO) interacts with multiple proteins. One specific interaction is characterized by the finding that synaptopodin competes with c-Cbl for binding to this partner, thereby preventing the ubiquitination of the partner by c-Cbl. Which protein corresponds to this interaction partner? | SH2/SH3 adapter protein NCK1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06259","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Synaptopodin (SYNPO) interacts with multiple proteins. One specific interaction is characterized by the finding that synaptopodin competes with c-Cbl... | |
medium_divergent_branch_06260 | The gene DCC interacts with multiple partners via binding. One specific interaction is described by the evidence: 'We find that sNetrin binds exclusively to the fifth fibronectin type III repeat of DCC and to each immunoglobulin repeat of UNC5.' Which protein is encoded by the gene that binds to DCC in this specific co... | Netrin-1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06260","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene DCC interacts with multiple partners via binding. One specific interaction is described by the evidence: 'We find that sNetrin binds exclusi... | |
medium_divergent_branch_06261 | PAX8 is involved in multiple biological processes. One of these processes is supported by evidence showing PAX8 expression in the developing central nervous system and kidney, specifically including the ureteric bud and the main collecting ducts. Which biological process is a part of the process connected to PAX8 via t... | nervous system development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06261","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PAX8 is involved in multiple biological processes. One of these processes is supported by evidence showing PAX8 expression in the developing central ... | |
medium_divergent_branch_06262 | PRKAA2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Our results indicate that AMPK is able to interact physically with this subunit and modify its phosphorylation status, supporting a possible role for AMPK in regulating proteasome function.' Which protein, connected to PRKAA2 vi... | 26S proteasome non-ATPase regulatory subunit 11 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06262","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PRKAA2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Our results indicate that AMPK is able to interact physic... | |
medium_divergent_branch_06263 | AKT1 interacts with multiple genes. One interaction is supported by evidence stating that a nitric oxide synthase-bound hsp90 recruits VEGF-activated (phosphorylated) Akt to a complex, where Akt phosphorylates the nitric oxide synthase. Which cell type is enriched for the gene involved in this specific interaction? | CD4-positive, alpha-beta memory T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06263","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"AKT1 interacts with multiple genes. One interaction is supported by evidence stating that a nitric oxide synthase-bound hsp90 recruits VEGF-activated... | |
medium_divergent_branch_06264 | HLA-C interacts with multiple genes. One interaction is supported by evidence stating: 'The association of p105 is transient, while p78, which we identified as the immunoglobulin binding protein [Gene], interacts permanently with Cw3 alpha chains.' Which disease is therapeutically linked to the gene described in this e... | transient ischemic attack | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06264","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HLA-C interacts with multiple genes. One interaction is supported by evidence stating: 'The association of p105 is transient, while p78, which we ide... | |
medium_divergent_branch_06265 | The gene P2RX4 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by experimental evidence showing that P2X4 receptors, but not P2X6 receptors, can be co-immunoprecipitated with VE-cadherin. Which molecular function, connected to this specific function ... | cell adhesion molecule binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06265","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene P2RX4 is associated with multiple molecular functions via the 'enables' relationship. One specific association is supported by experimental ... | |
medium_divergent_branch_06266 | GATA2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we report that the promyelocytic leukemia protein can complex with GATA-2 and potentiate its transactivation capacity.' Which protein is encoded by the gene corresponding to this interacting partner? | Protein PML | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06266","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GATA2 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here we report that the promyelocytic leukemia protein can... | |
medium_divergent_branch_06267 | RNF31 interacts with multiple proteins. One interaction is supported by evidence describing the structure of the fully active human HOIP RBR in its transfer complex with an E2~ubiquitin conjugate, which elucidates the intricate nature of RBR E3 ligases. Which protein product is encoded by the gene corresponding to this... | Ubiquitin-conjugating enzyme E2 D2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06267","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RNF31 interacts with multiple proteins. One interaction is supported by evidence describing the structure of the fully active human HOIP RBR in its t... | |
medium_divergent_branch_06268 | ACTN4 is associated with multiple molecular functions via the 'enables' relationship. One specific piece of evidence states: 'We show here that ACTN4 interacts with and enhances transcriptional activation by RARα.' Which molecular function, connected to the function supported by this evidence through an 'is_a' relation... | RNA polymerase II-specific DNA-binding transcription factor binding | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06268","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ACTN4 is associated with multiple molecular functions via the 'enables' relationship. One specific piece of evidence states: 'We show here that ACTN4... | |
medium_divergent_branch_06269 | FZR1 interacts with multiple genes. One of these interacting partners contains a KEN box sequence in its C-terminal region, which is required for its mitotic degradation and for its interaction with Cdh1. Which disease is associated with this specific interacting gene via a biomarker relationship? | lung neoplasm | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06269","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FZR1 interacts with multiple genes. One of these interacting partners contains a KEN box sequence in its C-terminal region, which is required for its... | |
medium_divergent_branch_06270 | APC is involved in multiple biological processes. One of these processes is supported by evidence showing that an APC variant lacking the direct microtubule binding site was more effective at downregulating beta-catenin. Which biological process is positively regulated by this specific APC-associated process? | protein catabolic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06270","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"APC is involved in multiple biological processes. One of these processes is supported by evidence showing that an APC variant lacking the direct micr... | |
medium_divergent_branch_06271 | PECAM1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Here we show that platelet endothelial cell adhesion molecule-1 (PECAM1), a key molecule in an endothelial mechanosensing complex, specifically mediates Gab1 tyrosine phosphorylation and its downstream A... | intracellular signal transduction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06271","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PECAM1 is associated with multiple biological processes. One specific association is supported by evidence stating: 'Here we show that platelet endot... | |
medium_divergent_branch_06273 | MOSPD2 is associated with multiple biological processes. One association is supported by evidence stating: 'Thus, in the presence of neutralizing Abs, neutrophil migration was inhibited to some extent whereas lymphocyte migration remained intact.' Which biological process is positively regulated by the specific process... | neutrophil chemotaxis | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06273","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MOSPD2 is associated with multiple biological processes. One association is supported by evidence stating: 'Thus, in the presence of neutralizing Abs... | |
medium_divergent_branch_06276 | EXOSC2 interacts with multiple proteins. One of these interaction partners is part of a complex where NMD factors, including Upf2 and Upf3X, coimmunopurify with the decapping enzyme Dcp2, the putative 5'-->3' exonuclease Rat1, the proven 5'-->3' exonuclease Xrn1, exosomal components PM/Scl100, Rrp4, and Rrp41, and PARN... | Regulator of nonsense transcripts 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06276","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"EXOSC2 interacts with multiple proteins. One of these interaction partners is part of a complex where NMD factors, including Upf2 and Upf3X, coimmuno... | |
medium_divergent_branch_06277 | The protein EMD (emerin) is associated with multiple cellular components via 'located in' relationships. One specific association is supported by evidence stating: 'We also find that a significant fraction of emerin is located at the outer nuclear membrane.' Based on this evidence, which cellular component is the corre... | nuclear outer membrane-endoplasmic reticulum membrane network | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06277","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein EMD (emerin) is associated with multiple cellular components via 'located in' relationships. One specific association is supported by evi... | |
medium_divergent_branch_06278 | ZHX1 interacts with multiple proteins. One of these interaction partners is characterized by evidence showing that it dimerizes with both ZHX1 and itself, and also interacts with the activation domain of NF-YA. Which protein is encoded by the gene corresponding to this interaction partner? | Zinc fingers and homeoboxes protein 3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06278","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ZHX1 interacts with multiple proteins. One of these interaction partners is characterized by evidence showing that it dimerizes with both ZHX1 and it... | |
medium_divergent_branch_06279 | The gene CDC73 is known to interact with multiple protein-coding genes. Experimental evidence indicates that the protein product of CDC73 (Parafibromin) interacts with muscle alpha-actinins (specifically actinin-2 and actinin-3) but does not interact with non-muscle alpha-actinins (actinin-1 and actinin-4). Based on th... | Alpha-actinin-3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06279","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene CDC73 is known to interact with multiple protein-coding genes. Experimental evidence indicates that the protein product of CDC73 (Parafibrom... | |
medium_divergent_branch_06280 | The gene NEDD9 is enriched in multiple cell types. One specific cell type shows a mean expression of 68.28 TPM, a z-score of 1.81, and a fold enrichment of 2.69. Which broader cell lineage is this specific cell type a subtype of? | monocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06280","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene NEDD9 is enriched in multiple cell types. One specific cell type shows a mean expression of 68.28 TPM, a z-score of 1.81, and a fold enrichm... | |
medium_divergent_branch_06281 | SH3RF2 interacts with multiple proteins. One specific interaction is supported by evidence stating: 'Proteomic analysis revealed that SH3RF2 interacted with this partner and regulated the ubiquitination of this partner with RING domain.' What is the name of the protein product encoded by the gene for this interaction p... | Leucine zipper putative tumor suppressor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06281","source_qa_id":"medium_divergent_branch_02150","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"SH3RF2 interacts with multiple proteins. One specific interaction is supported by evidence statin... | |
medium_divergent_branch_06282 | The gene BTRC interacts with multiple partners. One specific interaction is supported by evidence stating: 'In focused studies, we found that SCF(FBXW11) bound, polyubiquitylated, and destabilized this protein, a guanine nucleotide exchange factor that activates the small GTPase RAP1.' Which protein is encoded by the g... | Rap guanine nucleotide exchange factor 2 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06282","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene BTRC interacts with multiple partners. One specific interaction is supported by evidence stating: 'In focused studies, we found that SCF(FBX... | |
medium_divergent_branch_06283 | NOTCH2 is associated with multiple biological processes. One association is supported by evidence stating: 'During the earlier stages of tooth development, the Notch2 protein was expressed in the epithelium, but was absent from proliferating cells of the inner enamel epithelium.' Which biological process, connected to ... | animal organ development | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06283","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NOTCH2 is associated with multiple biological processes. One association is supported by evidence stating: 'During the earlier stages of tooth develo... | |
medium_divergent_branch_06284 | RBCK1 interacts with multiple genes. Evidence for one of these interactions states: 'We have identified a novel role for RBCK1 as an [interacting partner]-interacting protein, which regulates [interacting partner] stability at the post-translational level via ubiquitination.' Which disease is connected to this specific... | azoospermia | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06284","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RBCK1 interacts with multiple genes. Evidence for one of these interactions states: 'We have identified a novel role for RBCK1 as an [interacting par... | |
medium_divergent_branch_06285 | hsa-miR-101c regulates the differentiation of two distinct lymphocyte lineages. Evidence indicates that Hypocholesterolemia induces an oxidant stress-dependent increase in miR101c, which downregulates Tet1 in hematopoietic stem cells (HSC), thereby reducing the expression of genes critical for the differentiation of na... | mature NK T cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06285","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"hsa-miR-101c regulates the differentiation of two distinct lymphocyte lineages. Evidence indicates that Hypocholesterolemia induces an oxidant stress... | |
medium_divergent_branch_06286 | GNL3 interacts with multiple genes. One of these interaction partners is known to directly interact with and phosphorylate NS, thereby promoting its proteasomal degradation. Which gene connected to GNL3 via an interaction relationship exhibits this specific activity toward NS? | CDC25B | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06286","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"GNL3 interacts with multiple genes. One of these interaction partners is known to directly interact with and phosphorylate NS, thereby promoting its ... | |
medium_divergent_branch_06287 | HIP1 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence showing that HIP1 colocalizes with markers of clathrin-mediated endocytosis in neuronal cells and is highly enriched on clathrin-coated vesicles (CCVs) purified from brain homogenate... | coated vesicle | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06287","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HIP1 is associated with multiple cellular components via the 'located in' relationship. One specific association is supported by evidence showing tha... | |
medium_divergent_branch_06288 | CXCR4 is associated with multiple biological processes. One such association is supported by evidence stating: 'This study shows that coexpression of beta-arrestin with CXCR4 in human embryonic kidney 293 cells attenuated chemokine-stimulated G protein activation and inhibition of cAMP production.' Which molecular func... | G protein-coupled receptor activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06288","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CXCR4 is associated with multiple biological processes. One such association is supported by evidence stating: 'This study shows that coexpression of... | |
medium_divergent_branch_06289 | NHERF1 is associated with multiple biological processes. One association is supported by evidence that NHERF1-deficient mice exhibit intestinal brush border structural defects and disorganized ependymal cilia. Which biological process, connected to the process supported by this evidence via a 'part of' relationship, is... | endomembrane system organization | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06289","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NHERF1 is associated with multiple biological processes. One association is supported by evidence that NHERF1-deficient mice exhibit intestinal brush... | |
medium_divergent_branch_06290 | MIR495 is associated with multiple biological processes. One association is supported by evidence that MiR-495 significantly promoted HUVECs proliferation by altering cell cycle distribution and inhibited HUVECs apoptosis by affecting the expression of cleaved caspase 3. Which biological process is negatively regulated... | endothelial cell apoptotic process | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06290","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MIR495 is associated with multiple biological processes. One association is supported by evidence that MiR-495 significantly promoted HUVECs prolifer... | |
medium_divergent_branch_06291 | The NACA protein interacts with multiple partners. One specific interaction is supported by evidence stating: 'All NAC preparations to date consist of two copurifying polypeptides. Here we rigorously show that these two polypeptides, termed alpha- and betaNAC, form a very stable complex in vivo and in vitro and that a ... | Transcription factor BTF3 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06291","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The NACA protein interacts with multiple partners. One specific interaction is supported by evidence stating: 'All NAC preparations to date consist o... | |
medium_divergent_branch_06292 | Leukocytes are structurally part of multiple anatomical entities. One such entity is described as a semisolid gelatinous mass of coagulated blood consisting of red blood cells, white blood cells, and platelets entrapped in a fibrin network. What is the broader biological category (is_a) of this specific entity? | organism substance | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06292","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"Leukocytes are structurally part of multiple anatomical entities. One such entity is described as a semisolid gelatinous mass of coagulated blood con... | |
medium_divergent_branch_06293 | WDR82 interacts with multiple proteins. One interaction is supported by evidence describing a stable multimeric complex (the PTW/PP1 phosphatase complex) composed of regulatory subunits PNUTS, the interacting protein, and WDR82, along with a PP1 catalytic subunit. Which protein product is encoded by the gene correspond... | TOX high mobility group box family member 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06293","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"WDR82 interacts with multiple proteins. One interaction is supported by evidence describing a stable multimeric complex (the PTW/PP1 phosphatase comp... | |
medium_divergent_branch_06295 | The Endothelial cell-selective adhesion molecule (ESAM) is associated with multiple molecular functions. One specific association is supported by evidence stating that ESAM is a member of the immunoglobulin superfamily and mediates homophilic adhesion between endothelial cells. Which molecular function, connected to th... | cell adhesion mediator activity | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06295","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The Endothelial cell-selective adhesion molecule (ESAM) is associated with multiple molecular functions. One specific association is supported by evi... | |
medium_divergent_branch_06296 | CXCL13 is associated with multiple biological processes. One of these associations is supported by evidence stating: 'Our data suggest that CXCL13 may modulate angiogenesis by interfering with FGF-2 activity.' Which cell type is linked to this specific biological process via the 'enabled by cell' relationship? | secretory pericyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06296","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CXCL13 is associated with multiple biological processes. One of these associations is supported by evidence stating: 'Our data suggest that CXCL13 ma... | |
medium_divergent_branch_06297 | PSMD3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, we demonstrated that HsDSS1 regulates the human proteasome by associating with it in the cytosol and nucleus via the RPN3/S3 subunit of the 19S regulatory particle (RP).' Which disease is associated with the protein identif... | extragonadal germ cell tumor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06297","source_qa_id":"medium_divergent_branch_03728","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_node_selected","locator":"context","question":"PSMD3 interacts with multiple proteins. One interaction is supported by evidence stating: 'Here, ... | |
medium_divergent_branch_06298 | CNTFR is associated with multiple biological processes. One specific association is supported by evidence that GDE3 inhibits oligodendrocyte progenitor cell (OPC) proliferation by stimulating ciliary neurotrophic factor (CNTF)-mediated signaling through the release of CNTFRα, the ligand-binding component of the CNTF-re... | oligodendrocyte progenitor proliferation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06298","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CNTFR is associated with multiple biological processes. One specific association is supported by evidence that GDE3 inhibits oligodendrocyte progenit... | |
medium_divergent_branch_06299 | The alpha-beta T cell receptor complex is found in high amounts on the plasma membrane of multiple thymocyte populations. One such population is characterized by being CD8-positive, CD4-negative, and CD24-positive. Which specific thymocyte class, defined by its CD8 and CD4 expression status, corresponds to this descrip... | CD8-positive, alpha-beta thymocyte | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06299","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The alpha-beta T cell receptor complex is found in high amounts on the plasma membrane of multiple thymocyte populations. One such population is char... | |
medium_divergent_branch_06300 | ERBB4 is associated with multiple biological processes. One specific association is supported by evidence stating: 'In the lactating breast, ERBB4 localizes to the nuclei of secretory epithelium while regulating activities of the signal transducer and activator of transcription (STAT) 5A transcription factor essential ... | body fluid secretion | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06300","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"ERBB4 is associated with multiple biological processes. One specific association is supported by evidence stating: 'In the lactating breast, ERBB4 lo... | |
medium_divergent_branch_06301 | RSAD2 (Viperin) interacts with multiple proteins. One specific interaction involves a partner that is recruited by acetylated Viperin to stimulate K6-linked polyubiquitination at Lys206, thereby promoting Viperin degradation. Which protein corresponds to this specific interaction partner? | Ubiquitin conjugation factor E4 A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06301","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"RSAD2 (Viperin) interacts with multiple proteins. One specific interaction involves a partner that is recruited by acetylated Viperin to stimulate K6... | |
medium_divergent_branch_06302 | KLK3 interacts with multiple proteins. One interaction is supported by evidence stating: 'The high-molecular-mass form of a serine protease inhibitor, recognized by monoclonal antibodies against PSA, was dissociated by alkaline treatment into the low-molecular-mass form of the inhibitor and a 33-kDa protein identified ... | Plasma serine protease inhibitor | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06302","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KLK3 interacts with multiple proteins. One interaction is supported by evidence stating: 'The high-molecular-mass form of a serine protease inhibitor... | |
medium_divergent_branch_06303 | OFD1 interacts with multiple proteins. One of these interacting partners is described as a protein belonging to the AAA(+) family of ATPases, which has been recently associated with cystic kidney in zebrafish and with ciliary assembly and function in Chlamydomonas reinhardtii. Which protein is encoded by the gene corre... | RuvB-like 1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06303","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"OFD1 interacts with multiple proteins. One of these interacting partners is described as a protein belonging to the AAA(+) family of ATPases, which h... | |
medium_divergent_branch_06304 | HJURP interacts with multiple proteins. One specific interaction is characterized by the recruitment of HJURP to centromeres via a direct binding between the HJURP centromere targeting domain and the Mis18α-β C-terminal coiled-coil domains. Which protein, among those known to bind HJURP, is described by this mechanism? | NDEL1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06304","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"HJURP interacts with multiple proteins. One specific interaction is characterized by the recruitment of HJURP to centromeres via a direct binding bet... | |
medium_divergent_branch_06305 | CD48 is associated with multiple biological processes. One association is supported by evidence stating: 'These data show that the density of 2B4 and CD48 on both the NK cell and the potential target cell modulates NK cell activity.' Which biological process, connected to the process implied by this evidence via an 'is... | lymphocyte activation | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06305","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"CD48 is associated with multiple biological processes. One association is supported by evidence stating: 'These data show that the density of 2B4 and... | |
medium_divergent_branch_06306 | S100A8 is associated with multiple biological processes. One association is supported by evidence stating that these proteins are involved in neutrophil migration to inflammatory sites. Which biological process is a parent term (via 'is a') of the process described by this evidence? | leukocyte migration | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06306","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"S100A8 is associated with multiple biological processes. One association is supported by evidence stating that these proteins are involved in neutrop... | |
medium_divergent_branch_06307 | UFM1 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'The C-terminally processed Ufm1 is activated by a novel E1-like enzyme, [the interacting protein], by forming a high-energy thioester bond.' Which protein, connected to UFM1 via an interaction, is encoded by the gene in ... | Ubiquitin-like modifier-activating enzyme 5 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06307","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"UFM1 interacts with multiple proteins. One of these interactions is supported by evidence stating: 'The C-terminally processed Ufm1 is activated by a... | |
medium_divergent_branch_06308 | Primate erythroparvovirus 1 upregulates several genes. In the recorded experiment, one branch showed a log2 fold change of 1.014 and an adjusted p-value of 0.0429. Which disease has a genomic-alteration link with that selected gene? | lupus vulgaris | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06308","source_qa_id":"medium_divergent_branch_04647","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"divergent_branch_context_selected","locator":"context","question":"Primate erythroparvovirus 1 upregulates several genes. In the recorded experiment, one branch ... | |
medium_divergent_branch_06309 | The protein ACP2 is localized to multiple cellular components. One localization is supported by evidence stating: 'These polypeptides were further processed to mature forms with apparent Mr of 57,000, 48,000, and 43,000 that accumulated in the cells and were associated with dense lysosomes.' Identify the cellular compo... | lytic vacuole | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06309","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The protein ACP2 is localized to multiple cellular components. One localization is supported by evidence stating: 'These polypeptides were further pr... | |
medium_divergent_branch_06310 | MECP2 interacts with multiple proteins. One specific interaction is supported by evidence describing the 'Structure of the MeCP2-[Protein X] complex reveals a molecular basis for Rett syndrome and related disorders.' Which protein, connected to MECP2 via this interaction, is encoded by the gene in question? | F-box-like/WD repeat-containing protein TBL1XR1 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06310","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MECP2 interacts with multiple proteins. One specific interaction is supported by evidence describing the 'Structure of the MeCP2-[Protein X] complex ... | |
medium_divergent_branch_06311 | PLCB2 interacts with multiple proteins. One interaction is characterized by the statement: 'The kinase domain of this interacting partner directly associates with the C2 domain of phospholipase C (PLC).' Which protein product is encoded by the gene corresponding to this interacting partner? | Transient receptor potential cation channel subfamily M member 7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06311","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"PLCB2 interacts with multiple proteins. One interaction is characterized by the statement: 'The kinase domain of this interacting partner directly as... | |
medium_divergent_branch_06312 | FAM20C is associated with multiple cellular components via the 'located in' relationship. One piece of evidence states: 'We identified a family of atypical protein kinases that localize within the Golgi apparatus and are secreted.' Which cellular component is connected to the cellular component implied by this evidence... | extracellular region | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06312","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"FAM20C is associated with multiple cellular components via the 'located in' relationship. One piece of evidence states: 'We identified a family of at... | |
medium_divergent_branch_06313 | SNAP25 interacts with multiple genes. One specific interaction is supported by evidence stating: 'This platelet Sec1 protein (PSP) bound to a syntaxin family member and thereby excluded the binding of SNAP-25 with that syntaxin family member, an interaction critical to vesicle docking.' Which disease is associated with... | hearing loss, autosomal recessive 123 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06313","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"SNAP25 interacts with multiple genes. One specific interaction is supported by evidence stating: 'This platelet Sec1 protein (PSP) bound to a syntaxi... | |
medium_divergent_branch_06315 | MAP2 interacts with multiple proteins. One interaction is supported by evidence stating that a specific microtubule-associated protein was found to aggregate with MAP1 and MAP2 in solution. Which protein is encoded by the gene corresponding to this interaction partner? | Microtubule-associated protein tau | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06315","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"MAP2 interacts with multiple proteins. One interaction is supported by evidence stating that a specific microtubule-associated protein was found to a... | |
medium_divergent_branch_06316 | The gene PPP1R15A interacts with multiple other genes. One interaction is supported by evidence stating: 'The growth arrest and DNA damage-inducible protein, GADD34, was identified by its interaction with human inhibitor 1 (I-1), a protein kinase A (PKA)-activated inhibitor of type 1 protein serine/threonine phosphatas... | Protein phosphatase 1 regulatory subunit 1A | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06316","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene PPP1R15A interacts with multiple other genes. One interaction is supported by evidence stating: 'The growth arrest and DNA damage-inducible ... | |
medium_divergent_branch_06317 | The gene F2 (prothrombin) interacts with multiple partners. One specific interaction is characterized by kinetic data indicating that thrombin can bind to a specific endothelial cell surface membrane protein with a dissociation constant (Kd) of 8.6 nM, forming a complex that subsequently interacts with TAFI. Based on t... | acute myocardial infarction | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06317","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene F2 (prothrombin) interacts with multiple partners. One specific interaction is characterized by kinetic data indicating that thrombin can bi... | |
medium_divergent_branch_06318 | The gene MEF2C is involved in multiple biological processes. One such process is supported by evidence stating that inactivation of MEF2C in the neural crest of mice leads to reduced expression of melanocyte genes, defective differentiation, and significant loss of pigmentation at birth. Which cell type is the result o... | migratory neural crest cell | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06318","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"The gene MEF2C is involved in multiple biological processes. One such process is supported by evidence stating that inactivation of MEF2C in the neur... | |
medium_divergent_branch_06319 | TOB1 interacts with multiple proteins. One interaction is supported by the statement: 'We identified CRN7 as a Tob-interacting molecule.' Which protein is encoded by the gene corresponding to this specific interacting partner? | Coronin-7 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06319","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"TOB1 interacts with multiple proteins. One interaction is supported by the statement: 'We identified CRN7 as a Tob-interacting molecule.' Which prote... | |
medium_divergent_branch_06320 | KIF11 interacts with multiple proteins. One interaction was identified by immunoprecipitating a Flag-tagged protein and performing mass spectrometry, which revealed novel interacting partners including Eg5, PRMT5, and MYH-9. Which protein, connected to KIF11 via an interaction, is the subject of this specific experimen... | TNF receptor-associated factor 4 | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06320","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"KIF11 interacts with multiple proteins. One interaction was identified by immunoprecipitating a Flag-tagged protein and performing mass spectrometry,... | |
medium_divergent_branch_06321 | NOSIP interacts with multiple genes. One of these interaction partners is described as forming stable complexes with several importins (including a specific importin) and being imported into the nucleus by these factors. Which biological process is the gene corresponding to this description involved in? | protein import into nucleus | Medium | divergent_branch | {"qa_id":"medium_divergent_branch_06321","difficulty":"medium","subtype":"divergent_branch","detailed_subtype":"raw_json_context_selected","locator":"context","question":"NOSIP interacts with multiple genes. One of these interaction partners is described as forming stable complexes with several importins (including a s... |
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