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medium_hidden_intermediate_00934 | Human immunodeficiency virus 1 upregulates a gene that is enriched in naive CD4+ T cells. Evidence for this gene reports a log2 fold change of 1.850 and an adjusted p-value of 0.0006017. Which protein is encoded by this gene? | Zinc finger protein 391 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00934","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is enriched in naive CD4+ T cells. Evidence for this gene reports a l... | |
medium_hidden_intermediate_00935 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the extracellular region. Evidence for this specific gene reports a log2 fold change of -1.062 and an adjusted p-value of 0.002079. Which protein is encoded by this gene? | Alpha-1B-glycoprotein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00935","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is located in the extracellular region. Evid... | |
medium_hidden_intermediate_00936 | Human orthopneumovirus infection leads to the upregulation of certain genes whose products are located in the extracellular space. One such gene exhibits a log2 fold change of approximately 1.468 and an adjusted p-value of 0.02306 in cytotoxic T-lymphocytes. Which protein is encoded by this specific gene? | Leukemia inhibitory factor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00936","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human orthopneumovirus infection leads to the upregulation of certain genes whose products are located in the extracellular ... | |
medium_hidden_intermediate_00937 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the kinetochore. Evidence for one such gene reports a log2 fold change of 1.120 and an adjusted p-value of 3.958e-06. Which protein is encoded by that gene? | Aurora kinase B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00937","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is located in the kinetochore. Evidence for on... | |
medium_hidden_intermediate_00939 | In a study of choroid plexus epithelium (GSE157852), a gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in SARS-CoV-2 Infection. This specific gene exhibits a log2 fold change of -1.124 and an adjusted p-value of 0.002286. Which protein is encoded by this gene? | Nucleoporin NDC1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00939","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), a gene is downregulated by Severe acute respiratory syndrome-related co... | |
medium_hidden_intermediate_00940 | In a study of Measles morbillivirus infection, two genes are known to be upregulated by the virus and to interact with CTNNB1. One of these genes exhibits a log2 fold change of approximately 1.56 and an adjusted p-value of 0.0085. Which protein is encoded by this specific gene? | Mitogen-activated protein kinase kinase kinase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00940","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, two genes are known to be upregulated by the virus and to interact with CTNNB... | |
medium_hidden_intermediate_00941 | Cardiovirus A downregulates a gene that is involved in protein O-linked glycosylation. In a study of cervical adenocarcinoma cell lines (GSE122967), one such gene exhibited a log2 fold change of -1.483 and an adjusted p-value of 0.0163. Which protein is encoded by this specific gene? | Ribitol-5-phosphate transferase FKTN | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00941","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A downregulates a gene that is involved in protein O-linked glycosylation. In a study of cervical adenocarcinoma... | |
medium_hidden_intermediate_00942 | A gene is downregulated by Zika virus and participates in SARS-CoV infections. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -1.378 and an adjusted p-value of 0.01556. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00942","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Zika virus and participates in SARS-CoV infections. Experimental data for this gene in glioma ste... | |
medium_hidden_intermediate_00944 | In a study of lymphatic endothelial cells (GSE16354), a specific gene is downregulated by Human gammaherpesvirus 8 and its protein product binds to TAOK1. This gene exhibits a log2 fold change of -2.368 and an adjusted p-value of 0.00074. Which protein is encoded by this gene? | Borealin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00944","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lymphatic endothelial cells (GSE16354), a specific gene is downregulated by Human gammaherpesvirus 8 and its p... | |
medium_hidden_intermediate_00945 | Hepacivirus C is reported to downregulate a gene that is involved in the centrosome cycle. In a study of peripheral blood mononuclear cells (GSE119117), one such gene exhibited a log2 fold change of -1.047 and an adjusted p-value of 0.001448. Which protein is encoded by this specific gene? | HAUS augmin-like complex subunit 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00945","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that is involved in the centrosome cycle. In a study of peripheral blood mo... | |
medium_hidden_intermediate_00946 | VCP interacts with a specific protein that enables protein binding. Evidence regarding this protein states: 'We solved a crystal structure of the C-terminal heterodimerization domains of BAG6 and the protein and characterized their interaction biochemically.' Which cell type is this protein enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00946","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"VCP interacts with a specific protein that enables protein binding. Evidence regarding this protein states: 'We solved a cry... | |
medium_hidden_intermediate_00949 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in mitotic metaphase chromosome alignment. One of these genes exhibits a log2 fold change of approximately 1.706 and an adjusted p-value of 0.001836 in a specific cell type. Which cell type is enriched for this specific ... | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00949","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in mitotic metaphase chr... | |
medium_hidden_intermediate_00950 | In a study of cervical adenocarcinoma cells (GSE11238), a gene upregulated by Vaccinia virus and involved in Homology Directed Repair showed a log2 fold change of approximately 1.32 and an adjusted p-value of 0.0038. Which protein is encoded by this gene? | Lys-63-specific deubiquitinase BRCC36 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00950","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), a gene upregulated by Vaccinia virus and involved in Homology Direct... | |
medium_hidden_intermediate_00952 | Rhinovirus A infection is associated with the downregulation of specific genes that participate in Class A/1 (Rhodopsin-like receptors). In a study of cytotoxic T-lymphocytes (GSE106475), one such gene exhibited a log2 fold change of -2.538 and an adjusted p-value of 0.0004059. Which protein is encoded by this gene? | P2Y purinoceptor 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00952","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection is associated with the downregulation of specific genes that participate in Class A/1 (Rhodopsin-like... | |
medium_hidden_intermediate_00953 | Human immunodeficiency virus 1 upregulates a gene that is located in the mitochondrial inner membrane. Evidence for one such gene reports a log2 fold change of 1.749 and an adjusted p-value of 0.0005377. Which gene interacts with this specific upregulated gene? | CBY1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00953","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is located in the mitochondrial inner membrane. Evidence for one such... | |
medium_hidden_intermediate_00954 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Stimuli-sensing channels. One of these genes shows a log2 fold change of 1.437 and an adjusted p-value of 3.756e-05 in lung tissue. Which disease is associated with genomic alterations in this specific gene? | essential hypertension | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00954","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Stimuli-sensing channe... | |
medium_hidden_intermediate_00955 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' interaction and to MCM3 via a 'binds' interaction. One of these genes exhibits a log2 fold change of -1.704 and an adjusted p-value of 0.001904 in a specific study. Which cell type is this gene enriched in? | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00955","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' interaction... | |
medium_hidden_intermediate_00956 | Two genes are structurally linked to Cardiovirus A via a 'downregulates' relationship and to the Adaptive Immune System via a 'participates in' relationship. One of these genes has an associated expression profile showing a log2 fold change of -1.477 and an adjusted p-value of 0.01232. Which protein is encoded by the g... | E3 ubiquitin-protein ligase RNF138 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00956","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Cardiovirus A via a 'downregulates' relationship and to the Adaptive Immune System via ... | |
medium_hidden_intermediate_00957 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by the virus and is involved in autophagy. This gene exhibits a log2 fold change of approximately 1.411 and an adjusted p-value of 2.41e-09. Which protein is encoded by this gene? | Nuclear receptor-binding factor 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00957","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated by th... | |
medium_hidden_intermediate_00958 | Two genes are linked to Enterovirus A via upregulation and to prostate cancer via association. One of these genes exhibits a log2 fold change of approximately 1.29 and an adjusted p-value of approximately 0.0023 in rhabdomyosarcoma cells. Which protein is encoded by this specific gene? | Ankyrin repeat and KH domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00958","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Enterovirus A via upregulation and to prostate cancer via association. One of these genes exhibits a... | |
medium_hidden_intermediate_00959 | Hepacivirus C downregulates a gene that participates in the Immune System. Evidence for one such gene reports a log2 fold change of -1.065 and an adjusted p-value of 0.001403. Which cellular component is that gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00959","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that participates in the Immune System. Evidence for one such gene reports a log2 fold ch... | |
medium_hidden_intermediate_00962 | Two genes are upregulated by Vaccinia virus and associated with epilepsy. One of these genes shows a log2 fold change of 2.536 and an adjusted p-value of 3.622e-08 in cervical adenocarcinoma cell lines (study GSE11238). Which disease is linked to this specific gene through genomic alterations? | microcephaly | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00962","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and associated with epilepsy. One of these genes shows a log2 fold change of 2.5... | |
medium_hidden_intermediate_00963 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), a gene upregulated by Human respirovirus 3 serves as a biomarker for schizophrenia. This specific gene exhibits a log2 fold change of approximately 3.43 and an adjusted p-value of 0.0366. Which protein is encoded by this gene? | Stanniocalcin-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00963","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), a gene upregulated by Human respirovirus 3 serves a... | |
medium_hidden_intermediate_00964 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a specific gene, which subsequently interacts with PLK1. This gene exhibits a log2 fold change of approximately 1.051 and an adjusted p-value of 0.003093. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00964","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the upregulation of a specific gene, whic... | |
medium_hidden_intermediate_00965 | Two genes are downregulated by Pegivirus C and are involved in intracellular iron ion homeostasis. One of these genes exhibits a log2 fold change of -1.084 and an adjusted p-value of 0.0023 in peripheral blood mononuclear cells. Which disease is associated with this specific gene? | Ischemic stroke | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00965","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and are involved in intracellular iron ion homeostasis. One of these genes exhibi... | |
medium_hidden_intermediate_00966 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to Transmission across Chemical Synapses via a 'participates in' relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately -1.78 and a... | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00966","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_00967 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for non-small cell lung carcinoma. Evidence for this gene reports a log2 fold change of 1.518 and an adjusted p-value of 0.00951. Which protein is encoded by this gene? | UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00967","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for non-small cell ... | |
medium_hidden_intermediate_00968 | Neoplasms of connective and soft tissue can localize to synovial limb joints. One such joint is described as connecting the forelimb zeugopod and stylopod skeletons. Which anatomical structure does this specific joint develop from? | elbow joint primordium | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00968","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Neoplasms of connective and soft tissue can localize to synovial limb joints. One such joint is described as connecting the ... | |
medium_hidden_intermediate_00971 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and involved in mitochondrion organization. Evidence for this gene reports a log2 fold change of 1.606 and an adjusted p-value of 0.0087. Which protein is encoded by this gene? | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00971","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and involved i... | |
medium_hidden_intermediate_00973 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a specific gene that participates in phospholipid metabolism. This gene exhibits a log2 fold change of approximately -5.04 and an adjusted p-value of approximately 0.036. What molecular function is enabled by this gene? | A2-type glycerophospholipase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00973","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a specific gene that participates in pho... | |
medium_hidden_intermediate_00974 | Vaccinia virus upregulates a gene that participates in the sensory processing of sound. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately 4.26 and an adjusted p-value of approximately 5.16e-05. Which protein is encoded by this gene? | Calcium-binding protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00974","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that participates in the sensory processing of sound. Experimental data for this gene in a... | |
medium_hidden_intermediate_00975 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in G alpha (q) signalling events. Evidence for this gene reports a log2 fold change of 4.939 and an adjusted p-value of 0.04609. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00975","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in G alpha (q) signalling ev... | |
medium_hidden_intermediate_00976 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with lupus vulgaris. One of these genes exhibits a log2 fold change of 5.346 and an adjusted p-value of 0.0002854 in a specific study. Which biological process is the gene with these specific expression statistics invo... | defense response to virus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00976","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with lupus vulgaris. O... | |
medium_hidden_intermediate_00978 | A gene is upregulated by Human immunodeficiency virus 1 and participates in Neutrophil degranulation. Evidence for this gene in macrophages from study GSE108897 reports a log2 fold change of 2.644 and an adjusted p-value of 0.0001818. Which disease is connected to this gene through genomic alterations? | malignant pancreatic neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00978","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human immunodeficiency virus 1 and participates in Neutrophil degranulation. Evidence for this gene... | |
medium_hidden_intermediate_00979 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in the RAC1 GTPase cycle. One such gene exhibits a log2 fold change of 1.592 and an adjusted p-value of 0.0001023. Which protein is encoded by this specific gene? | Formin-like protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00979","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in the RAC1 GTPas... | |
medium_hidden_intermediate_00980 | Human betaherpesvirus 5 downregulates a gene that is involved in the response to ionizing radiation. In a study of foreskin fibroblast cell lines (GSE111036), one such gene exhibited a log2 fold change of approximately -1.27 and an adjusted p-value of 0.0483. Which disease is associated with this specific gene? | sarcoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00980","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 downregulates a gene that is involved in the response to ionizing radiation. In a study of foreskin ... | |
medium_hidden_intermediate_00981 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the epigenetic regulation of gene expression. Experimental data for this gene reports a log2 fold change of 3.337 and an adjusted p-value of 0.0001699. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00981","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the epigenetic regulation... | |
medium_hidden_intermediate_00983 | Human betaherpesvirus 5 is reported to downregulate a gene that is associated with retinoblastoma. In a study using foreskin fibroblast cell lines, one such gene exhibited a log2 fold change of approximately -1.155 and an adjusted p-value of 0.0036. Which protein is encoded by this specific gene? | Cannabinoid receptor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00983","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that is associated with retinoblastoma. In a study using foreskin... | |
medium_hidden_intermediate_00984 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes whose products are located in extracellular exosomes. One such gene exhibits a log2 fold change of -2.027 and an adjusted p-value of 0.001546. Which protein is encoded by this specific gene? | Thyrotropin-releasing hormone-degrading ectoenzyme | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00984","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes whose... | |
medium_hidden_intermediate_00985 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a specific gene, which in turn interacts with CLPP. This gene exhibits a log2 fold change of approximately -1.405 and an adjusted p-value of 0.01969. Which protein is encoded by this gene? | FAST kinase domain-containing protein 5, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00985","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a specific gene, which in turn interacts... | |
medium_hidden_intermediate_00987 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes that subsequently interact with the protein AIP. One such gene exhibited a log2 fold change of 1.678 and an adjusted p-value of 0.009139. Which protein is encoded by this specific gene? | Guanine nucleotide-binding protein subunit alpha-13 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00987","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes that subsequ... | |
medium_hidden_intermediate_00989 | Zika virus infection leads to the upregulation of certain genes that are involved in the negative regulation of autophagy. In a study of neural stem cells (GSE129180), one such upregulated gene exhibited a log2 fold change of approximately 1.154 and an adjusted p-value of 0.01581. Which protein is encoded by this speci... | Zinc finger protein with KRAB and SCAN domains 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00989","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection leads to the upregulation of certain genes that are involved in the negative regulation of autophagy. I... | |
medium_hidden_intermediate_00990 | Pegivirus C is reported to downregulate a specific gene that participates in Viral Infection Pathways. Transcriptomic data for this gene shows a log2 fold change of approximately -1.35 and an adjusted p-value of approximately 0.002. In which cell type is this gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00990","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene that participates in Viral Infection Pathways. Transcriptomic data f... | |
medium_hidden_intermediate_00991 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via downregulation and to habitual spontaneous abortion via association. One of these genes was reported in a study (GSE164073) involving sclera cells, with a log2 fold change of -1.240 and an adjusted p-value of 0.01921. Which protein is enc... | Aminopeptidase O | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00991","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via downregulation and to habitual spontaneous... | |
medium_hidden_intermediate_00992 | Two genes are each downregulated by Severe acute respiratory syndrome-related coronavirus and associated with anaplastic astrocytoma. One of these genes exhibits a log2 fold change of -2.860 and an adjusted p-value of 0.04277 in a specific study. Which gene is connected to this specific entity through a binds relations... | PRDM8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00992","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each downregulated by Severe acute respiratory syndrome-related coronavirus and associated with anaplastic ast... | |
medium_hidden_intermediate_00993 | In a study of natural killer cells (GSE125686), a gene is identified that is upregulated by Human immunodeficiency virus 1 and participates in sensory processing of sound. This specific gene exhibits a log2 fold change of 1.653 and an adjusted p-value of 0.02374. Which protein is encoded by this gene? | Small conductance calcium-activated potassium channel protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00993","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of natural killer cells (GSE125686), a gene is identified that is upregulated by Human immunodeficiency virus 1 a... | |
medium_hidden_intermediate_00994 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene, which in turn participates in mitochondrial protein degradation. This gene exhibited a log2 fold change of approximately 1.016 and an adjusted p-value of 0.03429. Which protein is encoded by this gene? | Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00994","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate a specific gene, which in ... | |
medium_hidden_intermediate_00995 | In a study of Measles morbillivirus infection, a gene is identified that is downregulated by the virus and participates in fatty acid metabolism. Evidence for this specific gene reports a log2 fold change of -1.005 and an adjusted p-value of 0.002998. Which protein is encoded by this gene? | Acyl-coenzyme A thioesterase 13 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00995","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a gene is identified that is downregulated by the virus and participates in f... | |
medium_hidden_intermediate_00996 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables G protein-coupled receptor activity. Evidence for this gene reports a log2 fold change of approximately 1.535 and an adjusted p-value of 0.04111. Which protein is encoded by this gene? | Adhesion G protein-coupled receptor L1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00996","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables G protein-coupled receptor activi... | |
medium_hidden_intermediate_00999 | A gene is downregulated by Pegivirus C and participates in disease processes. Experimental data for this gene shows a log2 fold change of approximately -1.35 and an adjusted p-value of approximately 0.002. In which cell type is this gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_00999","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Pegivirus C and participates in disease processes. Experimental data for this gene shows a log2 f... | |
medium_hidden_intermediate_01000 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and both bind to NRP1. One of these genes exhibits a log2 fold change of approximately -1.175 and an adjusted p-value of 0.01289 in a specific study. Which protein is encoded by this gene? | Dihydropyrimidinase-related protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01000","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and both bind to NRP1. One of these gen... | |
medium_hidden_intermediate_01001 | In a study of gamma delta T-lymphocytes (GSE13906), Human gammaherpesvirus 4 is reported to downregulate a specific gene that enables protein binding. This gene exhibits a log2 fold change of -1.319 and an adjusted p-value of 0.03811. Which biological process is this gene involved in? | apoptotic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01001","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of gamma delta T-lymphocytes (GSE13906), Human gammaherpesvirus 4 is reported to downregulate a specific gene tha... | |
medium_hidden_intermediate_01002 | Human betaherpesvirus 5 is reported to upregulate a gene that is associated with acute myeloid leukemia. In a study of foreskin fibroblast cell lines (GSE132081), one such gene exhibits a log2 fold change of 2.173 and an adjusted p-value of 1.636e-06. Which protein is encoded by this specific gene? | Extracellular sulfatase Sulf-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01002","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to upregulate a gene that is associated with acute myeloid leukemia. In a study of fores... | |
medium_hidden_intermediate_01004 | Two distinct biological processes serve as intermediate steps connecting 'cerebellar granular layer maturation' to 'cerebellar cortex development' via 'part of' relationships. One of these intermediate processes is defined by evidence stating it is a developmental process, independent of morphogenetic (shape) change, r... | anatomical structure development | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01004","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct biological processes serve as intermediate steps connecting 'cerebellar granular layer maturation' to 'cerebell... | |
medium_hidden_intermediate_01005 | In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upregulate a specific gene, which in turn binds to TCF7L2. This intermediate gene exhibited a log2 fold change of 1.359 and an adjusted p-value of 0.009369. Which gene interacts with this intermediate ... | SP1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01005","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upreg... | |
medium_hidden_intermediate_01006 | Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to Gamma delta(γδ) T cells via an 'enriched in' relationship. One of these genes exhibits a log2 fold change of -2.057 and an adjusted p-value of 0.0007 in a specific study. Which biological process is connected t... | protein O-linked glycosylation via glucose | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01006","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to Gamma delta(γδ... | |
medium_hidden_intermediate_01007 | Two genes are structurally linked from Human betaherpesvirus 5 via a downregulation relationship and subsequently to Natural killer cell via an enrichment relationship. One of these genes is associated with a log2 fold change of -1.342 and an adjusted p-value of 2.074e-10 in a specific study. Which cellular component i... | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01007","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Human betaherpesvirus 5 via a downregulation relationship and subsequently to Natural... | |
medium_hidden_intermediate_01008 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate certain genes whose protein products are located in the endosome membrane. One such gene exhibited a log2 fold change of approximately 1.62 and an adjusted p-value of 0.000138. Which protein is encoded by this speci... | WD repeat domain phosphoinositide-interacting protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01008","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate certain genes whose... | |
medium_hidden_intermediate_01009 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with sarcoma. One of these genes exhibits a log2 fold change of approximately -1.04 and an adjusted p-value of 0.02975 in a specific study. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01009","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are associated with sarcoma. One of... | |
medium_hidden_intermediate_01010 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the process 'PPARA activates gene expression'. Evidence for one such gene reports a log2 fold change of 1.118 and an adjusted p-value of 3.222e-05. Which disease is associated with that specific gene? | ulcerative colitis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01010","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in the process 'PPARA activates g... | |
medium_hidden_intermediate_01011 | Two genes are upregulated by Human immunodeficiency virus 1 and interact with YWHAE. One of these genes shows a log2 fold change of 1.500 and an adjusted p-value of 0.04441 in a specific study. Which disease is associated with genomic alterations in that specific gene? | steroid-responsive encephalopathy associated with autoimmune thyroiditis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01011","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and interact with YWHAE. One of these genes shows a log2 fold ch... | |
medium_hidden_intermediate_01012 | Measles morbillivirus upregulates a gene that binds to TAF9. Experimental data for this gene in pleural mesothelioma cells (study GSE117668) show a log2 fold change of approximately 1.09 and an adjusted p-value of 0.0029. Which protein is encoded by this gene? | Histone deacetylase complex subunit SAP130 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01012","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that binds to TAF9. Experimental data for this gene in pleural mesothelioma cells (... | |
medium_hidden_intermediate_01013 | Zika virus downregulates a specific gene, which in turn binds to RPS23. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -2.011 and an adjusted p-value of 0.02084. Which disease is associated with this gene as a biomarker? | adult lymphoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01013","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn binds to RPS23. Experimental data for this gene in glioma stem cells... | |
medium_hidden_intermediate_01014 | Measles morbillivirus upregulates a gene that participates in the RHOA GTPase cycle. Evidence for one such gene reports a log2 fold change of 1.025 and an adjusted p-value of 0.01133. Which protein is encoded by that gene? | FERM, ARHGEF and pleckstrin domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01014","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in the RHOA GTPase cycle. Evidence for one such gene reports a lo... | |
medium_hidden_intermediate_01015 | Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to PEX13 via a 'binds' relationship. One of these genes has an associated expression profile showing a log2 fold change of -1.076 and an adjusted p-value of 0.01583. Which cell type is this specific gene enriched ... | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01015","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to PEX13 via a 'b... | |
medium_hidden_intermediate_01016 | Zika virus downregulates a gene that interacts with RPL31. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of approximately -2.245 and an adjusted p-value of 0.04062. Which protein is encoded by this specific gene? | Nucleolar GTP-binding protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01016","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with RPL31. In a study of glioma stem cells (GSE114907), one such gene exhibi... | |
medium_hidden_intermediate_01018 | A gene is downregulated by Primate bocaparvovirus 1 and located in the extracellular exosome. Evidence for this gene reports a log2 fold change of -3.965 and an adjusted p-value of 0.01083. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01018","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and located in the extracellular exosome. Evidence for this gene reports... | |
medium_hidden_intermediate_01020 | In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and interacts with TP53. This specific gene exhibits a log2 fold change of 1.024 and an adjusted p-value of 0.03562. Which gene does this entity bind to? | PIP | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01020","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-Hodgkin lymphoma cell lines (GSE119608), a gene is upregulated by Human gammaherpesvirus 8 and interacts w... | |
medium_hidden_intermediate_01021 | Two genes are upregulated by Enterovirus A and interact with PTEN. One of these genes shows a log2 fold change of 1.204 and an adjusted p-value of 0.03278 in rhabdomyosarcoma cells. Which disease is associated with this specific gene? | colon carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01021","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Enterovirus A and interact with PTEN. One of these genes shows a log2 fold change of 1.204 and ... | |
medium_hidden_intermediate_01024 | Human immunodeficiency virus 1 downregulates a gene that enables RNA polymerase II cis-regulatory region sequence-specific DNA binding. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of -1.241 and an adjusted p-value of 0.02857. Which disease is associated with this gene? | acute leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01024","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that enables RNA polymerase II cis-regulatory region sequence-specific D... | |
medium_hidden_intermediate_01027 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to CTTN via a binding relationship. One of these genes exhibits a log2 fold change of 1.023 and an adjusted p-value of 0.007504 in choroid plexus epithelium data from study GSE157852. Which di... | clear cell renal carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01027","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship ... | |
medium_hidden_intermediate_01028 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate certain genes that participate in neutrophil degranulation. One such gene exhibited a log2 fold change of 2.811 and an adjusted p-value of 2.717e-10. Which protein is encoded by this specific gene? | Peroxiredoxin-4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01028","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate certain genes that ... | |
medium_hidden_intermediate_01029 | In a study of macrophages (GSE108897), a gene is identified as being upregulated by Human immunodeficiency virus 1 and serving as a biomarker for amyloidosis. This specific gene exhibits a log2 fold change of approximately 1.54 and an adjusted p-value of 1.46e-05. Which protein is encoded by this gene? | Palmitoyltransferase ZDHHC13 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01029","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified as being upregulated by Human immunodeficiency virus 1 and servi... | |
medium_hidden_intermediate_01031 | Hepacivirus C is reported to upregulate multiple genes that enable sequence-specific double-stranded DNA binding. One such gene exhibits a log2 fold change of 1.011 and an adjusted p-value of 5.497e-07 in liver cells. Which protein is encoded by this specific gene? | HMG box transcription factor BBX | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01031","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate multiple genes that enable sequence-specific double-stranded DNA binding. One such g... | |
medium_hidden_intermediate_01032 | In the context of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated by the virus and its product binds to SOCS3. Experimental data for this gene in lung tissue shows a log2 fold change of approximately 11.08 and an adjusted p-value of 0.0095. Which protein is encoded by thi... | Interferon alpha-8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01032","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In the context of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated by the vir... | |
medium_hidden_intermediate_01034 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with CDC20. Experimental data for this gene reports a log2 fold change of approximately 1.056 and an adjusted p-value of 0.004196. Which disease is associated with this gene as a biomarker? | oral cavity cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01034","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with CDC20. Experimental data f... | |
medium_hidden_intermediate_01035 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with BYSL. One of these genes shows a log2 fold change of approximately 1.05 and an adjusted p-value of 0.0029 in a specific study. Which protein is encoded by this gene? | F-box/LRR-repeat protein 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01035","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with BYSL. One of these gene... | |
medium_hidden_intermediate_01036 | In a study of Influenza A virus infection, a specific gene is upregulated by the virus and is involved in cell-cell signaling. Experimental data for this gene reports a log2 fold change of approximately 3.074 and an adjusted p-value of 0.0008761. Which protein is encoded by this gene? | Tumor necrosis factor-inducible gene 6 protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01036","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated by the virus and is involved in cell-cell signalin... | |
medium_hidden_intermediate_01037 | Enterovirus A upregulates a specific gene that subsequently interacts with RPA2. Experimental data for this gene in rhabdomyosarcoma cells indicates a log2 fold change of approximately 1.345 and an adjusted p-value of approximately 0.020. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01037","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates a specific gene that subsequently interacts with RPA2. Experimental data for this gene in rhabdomy... | |
medium_hidden_intermediate_01040 | Two genes are known to be downregulated by Vaccinia virus and to interact with TP53. One of these genes exhibits a log2 fold change of approximately -1.145 and an adjusted p-value of 0.006754 in a specific study. Which cell type is this gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01040","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are known to be downregulated by Vaccinia virus and to interact with TP53. One of these genes exhibits a log2 fold... | |
medium_hidden_intermediate_01041 | Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to classic familial adenomatous polyposis via an association relationship. One of these genes exhibits a log2 fold change of approximately -1.205 and an adjusted p-value of 0.008818 in macrophages (study GSE108897)... | PDZ domain-containing protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01041","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a downregulation relationship and to classic familia... | |
medium_hidden_intermediate_01042 | A gene is downregulated by Cardiovirus A and participates in Glycosphingolipid metabolism. Evidence for this gene reports a log2 fold change of -1.057 and an adjusted p-value of 0.02274. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01042","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Cardiovirus A and participates in Glycosphingolipid metabolism. Evidence for this gene reports a ... | |
medium_hidden_intermediate_01044 | Rhinovirus A downregulates multiple genes that are associated with disease. One such gene exhibits a log2 fold change of approximately -1.90 and an adjusted p-value of approximately 0.00096 in cytotoxic T-lymphocytes. Which protein interacts with this specific gene product? | USP3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01044","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A downregulates multiple genes that are associated with disease. One such gene exhibits a log2 fold change of app... | |
medium_hidden_intermediate_01045 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene located in the microtubule cytoskeleton. One such gene exhibited a log2 fold change of -1.144 and an adjusted p-value of 0.01271. Which protein is encoded by this specific gene? | Cytoskeleton-associated protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01045","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene located in the microt... | |
medium_hidden_intermediate_01047 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is enriched in Memory CD8+ T cells. Evidence for this gene reports a log2 fold change of -1.310 and an adjusted p-value of 0.00744. Which protein is encoded by this gene? | bMERB domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01047","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is enriched in Memory CD8+ T cells. Evi... | |
medium_hidden_intermediate_01049 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables G protein-coupled receptor activity. Experimental data for this gene reports a log2 fold change of -1.108 and an adjusted p-value of 0.0144. Which biological process is this gene involved in? | G protein-coupled receptor signaling pathway | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01049","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables G protein-coupled receptor acti... | |
medium_hidden_intermediate_01050 | Zika virus downregulates a specific gene, which in turn interacts with ILF3. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -2.667 and an adjusted p-value of 0.004134. Which disease is associated with this gene? | obesity disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01050","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with ILF3. Experimental data for this gene in glioma stem ... | |
medium_hidden_intermediate_01051 | The carpus endochondral element is a type of limb endochondral element via an intermediate anatomical class. Evidence for this intermediate class states: 'A carpus bone or its cartilage or pre-cartilage precursor.' Which anatomical structure is the intermediate class a part of? | forelimb skeleton | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01051","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"The carpus endochondral element is a type of limb endochondral element via an intermediate anatomical class. Evidence for th... | |
medium_hidden_intermediate_01052 | Severe acute respiratory syndrome-related coronavirus is reported to downregulate a gene that enables DNA binding and bending. Evidence for one such gene shows a log2 fold change of -1.354 and an adjusted p-value of 0.04464. Which protein is encoded by this gene? | Hematopoietically-expressed homeobox protein HHEX | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01052","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus is reported to downregulate a gene that enables DNA binding and bendin... | |
medium_hidden_intermediate_01055 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which in turn interacts with WDR61. This gene exhibited a log2 fold change of 1.123 and an adjusted p-value of 2.57e-05. Which protein is encoded by this upregulated gene? | Prefoldin subunit 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01055","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_01057 | Two genes are upregulated by Measles morbillivirus and interact with DYNLL1. One of these genes shows a log2 fold change of 1.593 and an adjusted p-value of 0.02667 in a specific study. Which cell type is enriched for this specific gene? | non-classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01057","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Measles morbillivirus and interact with DYNLL1. One of these genes shows a log2 fold change of ... | |
medium_hidden_intermediate_01059 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. Experimental evidence for this gene reports a log2 fold change of -1.861 and an adjusted p-value of 0.0002217. Which molecular function is enable... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01059","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Immunoregulatory intera... | |
medium_hidden_intermediate_01060 | Human betaherpesvirus 5 is reported to downregulate a gene that subsequently interacts with PRKN. Experimental data for one such gene indicates a log2 fold change of -1.115 and an adjusted p-value of 0.047. In which cell type is this specific gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01060","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that subsequently interacts with PRKN. Experimental data for one ... | |
medium_hidden_intermediate_01064 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes whose products are located in the extracellular space. One such gene exhibits a log2 fold change of approximately -1.72 and an adjusted p-value of approximately 0.005. Which protein is encoded by this ... | Ribonuclease 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01064","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes whose... | |
medium_hidden_intermediate_01065 | Two genes are structurally linked to Cardiovirus A via a downregulation relationship and to squamous cell carcinoma via an association relationship. One of these genes has a reported log2 fold change of -1.561 and an adjusted p-value of 0.01042 in a specific study context. Which protein is encoded by the gene matching ... | G2/mitotic-specific cyclin-B2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01065","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Cardiovirus A via a downregulation relationship and to squamous cell carcinoma via an a... | |
medium_hidden_intermediate_01066 | Human polyomavirus 1 upregulates a gene that participates in cellular responses to stress. Evidence for this gene reports a log2 fold change of approximately 3.78 and an adjusted p-value of 0.04793. Which protein is encoded by this gene? | S-adenosylmethionine sensor upstream of mTORC1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01066","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human polyomavirus 1 upregulates a gene that participates in cellular responses to stress. Evidence for this gene reports a ... | |
medium_hidden_intermediate_01067 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes whose products are located in the extracellular space. One such gene exhibited a log2 fold change of approximately 3.12 and an adjusted p-value of 0.0126. Which protein is encoded by this specific gene? | C-C motif chemokine 28 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01067","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes whose produc... | |
medium_hidden_intermediate_01068 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a gene that subsequently interacts with BAG2. One such gene exhibits a log2 fold change of -4.817 and an adjusted p-value of 0.01482. Which cellular component is this specific gene located in? | protein phosphatase type 2A complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01068","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a gene that subsequently interacts with ... | |
medium_hidden_intermediate_01069 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with gastric cancer. One of these genes exhibits a log2 fold change of 1.707 and an adjusted p-value of 2.74e-06 in choroid plexus epithelium. Which disease is connected to this specific gene via a protective relations... | amyloidosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01069","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with gastric cancer. O... | |
medium_hidden_intermediate_01070 | Zika virus downregulates a gene that is located in the recycling endosome. Experimental data from glioma stem cells (study GSE114907) indicates that one such gene has a log2 fold change of approximately -1.61 and an adjusted p-value of approximately 0.0037. Which protein is encoded by this specific gene? | Phospholipid-transporting ATPase IF | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_01070","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the recycling endosome. Experimental data from glioma stem cells (study G... |
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