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medium_convergence_01317 | YAP1 and CREBBP both interact with a specific shared protein. Experimental evidence indicates that YAP1 interacts with this protein's PY motif via its WW domains, thereby preventing the E3 ubiquitin ligase WWP1 from ubiquitinating it. Which protein is this shared entity? | Krueppel-like factor 5 | Medium | convergence | {"qa_id":"medium_convergence_01317","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and CREBBP both interact with a specific shared protein. Experimental evidence indicates that YAP1 interacts with this protein's PY motif via its WW dom... | |
medium_convergence_01318 | ESR1 and AR share multiple interacting partners. One such shared partner is implicated in the regulation of HOXA10, where its knockdown suppresses HOXA10 activation and it binds to the HOXA10 promoter's estrogen response element (ERE) in an estradiol-dependent manner by forming a complex with ERα. Which protein is enco... | Histone-lysine N-methyltransferase 2A | Medium | convergence | {"qa_id":"medium_convergence_01318","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and AR share multiple interacting partners. One such shared partner is implicated in the regulation of HOXA10, where its knockdown suppresses HOXA10 act... | |
medium_convergence_01319 | TRIM28 and PSME3 both interact with a specific shared protein. Evidence regarding this shared entity states: 'We additionally found that REGgamma interacts with the DNA damage checkpoint kinase [CHEK2], whose presence is necessary for the increase of PML-NBs induced by REGgamma deficiency, and that REGgamma depletion r... | Serine/threonine-protein kinase Chk2 | Medium | convergence | {"qa_id":"medium_convergence_01319","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRIM28 and PSME3 both interact with a specific shared protein. Evidence regarding this shared entity states: 'We additionally found that REGgamma interacts w... | |
medium_convergence_01321 | DNAH5 and ODAD1 are both involved in multiple shared biological processes. One of these shared processes is linked to an entity for which evidence indicates that, in patients with Primary Ciliary Dyskinesia (PCD) carrying mutations in that entity (n=3) or DNAI1 (n=1), the protein was completely or only distally absent ... | axonemal dynein complex assembly | Medium | convergence | {"qa_id":"medium_convergence_01321","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNAH5 and ODAD1 are both involved in multiple shared biological processes. One of these shared processes is linked to an entity for which evidence indicates ... | |
medium_convergence_01322 | BRD4 and TMPO both interact with a specific shared protein. Evidence regarding this shared entity states: 'Here I identified a LAP2 interacting protein, termed L2BP1 (LAP2 binding protein 1).' Which protein is encoded by this shared entity? | Barrier-to-autointegration factor | Medium | convergence | {"qa_id":"medium_convergence_01322","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD4 and TMPO both interact with a specific shared protein. Evidence regarding this shared entity states: 'Here I identified a LAP2 interacting protein, term... | |
medium_convergence_01323 | DLG2 and DLG4 both interact with a specific protein that belongs to a novel family named SAPAPs (SAP90/PSD-95-Associated Proteins), which specifically interact with PSD-95/SAP90 and related proteins through the guanylate kinase domain. Which cellular component is this SAPAP family member located in? | neurofilament | Medium | convergence | {"qa_id":"medium_convergence_01323","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DLG2 and DLG4 both interact with a specific protein that belongs to a novel family named SAPAPs (SAP90/PSD-95-Associated Proteins), which specifically intera... | |
medium_convergence_01324 | SMAD3 and SMAD4 both interact with a specific protein. Evidence indicates that the acetylation of SMAD3 at lysine residues K20 and K117 by KAT6A promotes SMAD3's association with the oncogenic chromatin modifier TRIM24 and disrupts its interaction with a tumor suppressor protein. This tumor suppressor is the shared int... | E3 ubiquitin-protein ligase TRIM33 | Medium | convergence | {"qa_id":"medium_convergence_01324","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD3 and SMAD4 both interact with a specific protein. Evidence indicates that the acetylation of SMAD3 at lysine residues K20 and K117 by KAT6A promotes SMA... | |
medium_convergence_01325 | Human polyomavirus 1 and Enterovirus A both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) reports a log2 fold change of approximately 1.399 and an adjusted p-value of approximately 0.02003. In which cellular component is this gene product located? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_01325","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Enterovirus A both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) reports a... | |
medium_convergence_01326 | DIS3 and NCBP2 share a common interacting partner. Evidence indicates that this partner protein binds the cap-binding complex (CBC), which is universally present on capped RNAs, and also associates with the nuclear exosome targeting (NEXT) complex, thereby linking to RNA decay. Which biological process is this shared p... | RNA destabilization | Medium | convergence | {"qa_id":"medium_convergence_01326","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DIS3 and NCBP2 share a common interacting partner. Evidence indicates that this partner protein binds the cap-binding complex (CBC), which is universally pre... | |
medium_convergence_01327 | MAPK14 and CSNK2A1 both interact with a shared protein target. Experimental evidence indicates that p38 (encoded by MAPK14) binds and phosphorylates this specific target at serines 309 and 361, a modification required for binding to 14-3-3 proteins. Which protein is encoded by the gene corresponding to this phosphoryla... | M-phase inducer phosphatase 2 | Medium | convergence | {"qa_id":"medium_convergence_01327","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAPK14 and CSNK2A1 both interact with a shared protein target. Experimental evidence indicates that p38 (encoded by MAPK14) binds and phosphorylates this spe... | |
medium_convergence_01328 | Human orthopneumovirus and Zika virus both upregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 1.189 and an adjusted p-value of 0.04964. Which molecular function is enabled by this gene? | DNA-binding transcription factor activity | Medium | convergence | {"qa_id":"medium_convergence_01328","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human orthopneumovirus and Zika virus both upregulate a specific gene. Evidence for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log... | |
medium_convergence_01329 | Both CDC37 and HDLBP interact with a common protein. Evidence indicates that HDLBP interacts with this shared protein and inhibits its ubiquitinated degradation by abrogating interactions between this protein and ITCH. Which protein is encoded by this shared entity? | Serine/threonine-protein kinase B-raf | Medium | convergence | {"qa_id":"medium_convergence_01329","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both CDC37 and HDLBP interact with a common protein. Evidence indicates that HDLBP interacts with this shared protein and inhibits its ubiquitinated degradat... | |
medium_convergence_01331 | CREBBP and EP300 both interact with a specific shared protein. Experimental evidence indicates that p300 directly acetylates this shared protein at the K409 residue in osteosarcoma MG-63 and HOS cells. Which protein is encoded by the gene corresponding to this shared entity? | Lysine-specific demethylase 2A | Medium | convergence | {"qa_id":"medium_convergence_01331","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and EP300 both interact with a specific shared protein. Experimental evidence indicates that p300 directly acetylates this shared protein at the K409 ... | |
medium_convergence_01332 | CREBBP and EGLN1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In the mammalian two-hybrid system, CAD and NAD baits enhanced the luciferase expression from a reporter gene by co-transfection with CREB-binding protein (CBP) prey, whereas CAD, but not NAD, enhanced beta... | Hypoxia-inducible factor 1-alpha | Medium | convergence | {"qa_id":"medium_convergence_01332","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and EGLN1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In the mammalian two-hybrid system, CAD and... | |
medium_convergence_01334 | KCTD7 and ATXN3 both interact with a specific protein. Evidence indicates that this protein is ubiquitinated at lysine residues K280 and K674 by a complex containing KCTD7, Cullin-3, and Rbx1. Which protein is encoded by the gene corresponding to this ubiquitinated entity? | Calpain-2 catalytic subunit | Medium | convergence | {"qa_id":"medium_convergence_01334","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KCTD7 and ATXN3 both interact with a specific protein. Evidence indicates that this protein is ubiquitinated at lysine residues K280 and K674 by a complex co... | |
medium_convergence_01335 | ARPC3 and ARPC2 both interact with a shared protein partner. Evidence for one such partner indicates that its NTA region interacts directly with the Arp2/3 complex, as demonstrated by affinity chromatography, immunoprecipitation assays, and binding assays using purified components. Which protein is encoded by the gene ... | Src substrate cortactin | Medium | convergence | {"qa_id":"medium_convergence_01335","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARPC3 and ARPC2 both interact with a shared protein partner. Evidence for one such partner indicates that its NTA region interacts directly with the Arp2/3 c... | |
medium_convergence_01336 | HECTD1 and HDAC1 share multiple protein interaction partners. One such shared partner is described in the following evidence: 'We now report that RFC (p140) associates with histone deacetylase activity and interacts with histone deacetylase 1 (HDAC1).' Which protein is encoded by the gene corresponding to this shared i... | Replication factor C subunit 1 | Medium | convergence | {"qa_id":"medium_convergence_01336","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HECTD1 and HDAC1 share multiple protein interaction partners. One such shared partner is described in the following evidence: 'We now report that RFC (p140) ... | |
medium_convergence_01337 | HDAC1 and HIST2H3A share multiple binding partners. One shared partner is implicated in epigenetic regulatory complexes associated with H3-K4 methylation in the testis, specifically involving the association of a histone demethylase and methyl-CpG-binding domain protein 2 (MBD2) in a complex with histone deacetylase 1.... | Lysine-specific histone demethylase 1A | Medium | convergence | {"qa_id":"medium_convergence_01337","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and HIST2H3A share multiple binding partners. One shared partner is implicated in epigenetic regulatory complexes associated with H3-K4 methylation in ... | |
medium_convergence_01338 | XRCC6 and NUMA1 both interact with a shared protein. Evidence regarding this shared entity states: 'In addition to TRF2, we found DNA repair proteins Rad50, Mre11, PARP1 (poly(ADP-ribose) polymerase), and Ku86/Ku70 to be in this telomeric complex.' Which protein is encoded by this shared entity? | Telomeric repeat-binding factor 2-interacting protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01338","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"XRCC6 and NUMA1 both interact with a shared protein. Evidence regarding this shared entity states: 'In addition to TRF2, we found DNA repair proteins Rad50, ... | |
medium_convergence_01339 | BRD4 and PCNA share interaction partners. One such shared partner is implicated in a study stating: 'We found that the extraterminal (ET) domain, whose function has to date not been determined, interacts with NSD3, JMJD6, CHD4, GLTSCR1, and this protein.' Which protein is encoded by this shared interaction partner? | ATPase family AAA domain-containing protein 5 | Medium | convergence | {"qa_id":"medium_convergence_01339","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRD4 and PCNA share interaction partners. One such shared partner is implicated in a study stating: 'We found that the extraterminal (ET) domain, whose funct... | |
medium_convergence_01340 | RAD51 and BRIP1 both interact with a common protein partner. Evidence regarding this partner indicates that in assays using purified components, phosphorylation of RAD51 by c-Abl enhances complex formation between RAD51 and this partner, which cooperates with RAD51 in recombination and repair. Which disease is associat... | cervical squamous cell carcinoma | Medium | convergence | {"qa_id":"medium_convergence_01340","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RAD51 and BRIP1 both interact with a common protein partner. Evidence regarding this partner indicates that in assays using purified components, phosphorylat... | |
medium_convergence_01341 | Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for this gene in a lung fibroblast cell line (study GSE120891) reports a log2 fold change of approximately 2.155 and an adjusted p-value of 0.03813. Which cell type is ... | regulatory T cell | Medium | convergence | {"qa_id":"medium_convergence_01341","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are known to upregulate a specific shared gene. Experimental data for t... | |
medium_convergence_01342 | HDAC1 and AR each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Interaction studies revealed unique epigenetic regulatory complexes associated with H3-K4 methylation in the testis, including the association of a histone demethylase and methyl-CpG-binding domain protein 2 (M... | Lysine-specific histone demethylase 1A | Medium | convergence | {"qa_id":"medium_convergence_01342","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and AR each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Interaction studies revealed unique epigenetic ... | |
medium_convergence_01343 | STAMBP and WWP1 share interaction partners. One such shared partner is a cytoplasmic protein, previously termed associated molecule with the SH3 domain of STAM (AMSH), which has been identified as a direct binding partner for this entity. Which protein is connected to that entity through the 'encodes' relationship? | SMAD family member 6 | Medium | convergence | {"qa_id":"medium_convergence_01343","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STAMBP and WWP1 share interaction partners. One such shared partner is a cytoplasmic protein, previously termed associated molecule with the SH3 domain of ST... | |
medium_convergence_01344 | West Nile virus and Primate bocaparvovirus 1 both upregulate a shared gene. Experimental data for this gene in monocyte-derived dendritic cells reports a log2 fold change of approximately 1.045 and an adjusted p-value of 0.004282. Which cell type is this gene enriched in? | non-classical monocyte | Medium | convergence | {"qa_id":"medium_convergence_01344","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"West Nile virus and Primate bocaparvovirus 1 both upregulate a shared gene. Experimental data for this gene in monocyte-derived dendritic cells reports a log... | |
medium_convergence_01346 | Human respirovirus 3 and Human immunodeficiency virus 1 both upregulate a specific gene. Evidence for one such shared target reports a log2 fold change of 2.826 and an adjusted p-value of 0.04216. Which disease is associated with this gene through genomic alterations? | colorectal carcinoma | Medium | convergence | {"qa_id":"medium_convergence_01346","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human respirovirus 3 and Human immunodeficiency virus 1 both upregulate a specific gene. Evidence for one such shared target reports a log2 fold change of 2.... | |
medium_convergence_01347 | EP300 and MAX both interact with a shared protein. Evidence regarding this shared entity states: 'Immunoprecipitation and DNA affinity protein binding assays revealed the association of c-Jun and p300 via [the shared entity] and the dissociation of histone deacetylase 1 (HDAC1) via c-Jun recruitment to the CCAAT boxes ... | Nuclear transcription factor Y subunit alpha | Medium | convergence | {"qa_id":"medium_convergence_01347","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and MAX both interact with a shared protein. Evidence regarding this shared entity states: 'Immunoprecipitation and DNA affinity protein binding assays... | |
medium_convergence_01348 | CSTF2 and CDC5L each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'In CstF-64, a small region, highly conserved in metazoa, is responsible for interactions with two proteins, [a protein encoded by CSTF3] and symplekin, a nuclear protein of previously unknown fun... | Cleavage stimulation factor subunit 3 | Medium | convergence | {"qa_id":"medium_convergence_01348","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSTF2 and CDC5L each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'In CstF-64, a small region, high... | |
medium_convergence_01349 | EP300 and MYC both interact with a shared transcription factor subunit. Experimental evidence indicates that immunoprecipitation and DNA affinity protein binding assays revealed the association of c-Jun and p300 via this specific subunit, alongside the dissociation of histone deacetylase 1 (HDAC1) via c-Jun recruitment... | Nuclear transcription factor Y subunit alpha | Medium | convergence | {"qa_id":"medium_convergence_01349","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and MYC both interact with a shared transcription factor subunit. Experimental evidence indicates that immunoprecipitation and DNA affinity protein bin... | |
medium_convergence_01350 | UBA52 and UBC each interact with more than one shared gene. Evidence concerning one shared entity reports: 'We report the 1.45 A resolution crystal structure of human UCH-L3 in complex with the inhibitor ubiquitin vinylmethylester, an inhibitor that forms a covalent adduct with the active site cysteine of ubiquitin-spe... | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_01350","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"UBA52 and UBC each interact with more than one shared gene. Evidence concerning one shared entity reports: 'We report the 1.45 A resolution crystal structure... | |
medium_convergence_01351 | KAT5 and NFIA both interact with a specific protein. Evidence regarding this protein states: 'This modification occurred at lysine 758 and catalysed by Tip60.' Which protein is encoded by the gene corresponding to this interacting partner? | Lysine-specific demethylase 2B | Medium | convergence | {"qa_id":"medium_convergence_01351","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"KAT5 and NFIA both interact with a specific protein. Evidence regarding this protein states: 'This modification occurred at lysine 758 and catalysed by Tip60... | |
medium_convergence_01352 | STX17 and STX3 both interact with a specific R-SNARE protein. Evidence indicates that a SNARE domain-disrupted isoform of this protein competes with its functional isoform to bind to STX17, thereby inhibiting autophagosome-lysosome fusion. Which cell type is enriched for this R-SNARE protein? | basophil | Medium | convergence | {"qa_id":"medium_convergence_01352","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"STX17 and STX3 both interact with a specific R-SNARE protein. Evidence indicates that a SNARE domain-disrupted isoform of this protein competes with its func... | |
medium_convergence_01353 | Rhinovirus A and Zika virus both upregulate a specific gene. Experimental data from cytotoxic T-lymphocytes (study GSE106475) indicates that for one such shared target, the log2 fold change is approximately 1.719 and the adjusted p-value is 0.001344. Which disease is associated with this specific gene? | nephrotic syndrome, type 21 | Medium | convergence | {"qa_id":"medium_convergence_01353","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zika virus both upregulate a specific gene. Experimental data from cytotoxic T-lymphocytes (study GSE106475) indicates that for one such sha... | |
medium_convergence_01354 | GPS2 and H3C1 each interact with more than one shared protein. Evidence concerning one shared entity reports that a histone demethylase is inhibited by a demethylated peptide with an inhibition constant of 1.8 microM, suggesting that this enzyme can bind to H3 independently of Lys4 methylation. Which protein is connect... | Lysine-specific histone demethylase 1A | Medium | convergence | {"qa_id":"medium_convergence_01354","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GPS2 and H3C1 each interact with more than one shared protein. Evidence concerning one shared entity reports that a histone demethylase is inhibited by a dem... | |
medium_convergence_01355 | Vaccinia virus and Enterovirus A both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) shows a log2 fold change of approximately -4.57 and an adjusted p-value of approximately 0.022. Which biological process is this gene involved in? | positive regulation of membrane protein ectodomain proteolysis | Medium | convergence | {"qa_id":"medium_convergence_01355","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Enterovirus A both downregulate a specific gene. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) s... | |
medium_convergence_01356 | GAS6 and AXL are both implicated in multiple shared biological processes. One such process involves the phagocytic clearance of apoptotic cells, a mechanism known to require bridging by GAS6. Which broader biological category is this specific process a subclass of? | endocytosis | Medium | convergence | {"qa_id":"medium_convergence_01356","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GAS6 and AXL are both implicated in multiple shared biological processes. One such process involves the phagocytic clearance of apoptotic cells, a mechanism ... | |
medium_convergence_01357 | EZH2 and SIRT1 share common interaction partners. One such shared partner is characterized by evidence showing that SIRT1 interacts directly with it and is recruited to the promoter template in a manner dependent on this partner, resulting in transcriptional repression. Which disease is associated with this specific sh... | stroke disorder | Medium | convergence | {"qa_id":"medium_convergence_01357","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EZH2 and SIRT1 share common interaction partners. One such shared partner is characterized by evidence showing that SIRT1 interacts directly with it and is r... | |
medium_convergence_01358 | CRK and CRKL each interact with more than one shared protein partner. Evidence concerning one shared entity reports that a kinase binding to the first SH3 domain of this entity is direct and occurs via proline-rich motifs in the C-terminal, non-catalytic portion of that kinase. Which disease is associated with that ent... | leukemia | Medium | convergence | {"qa_id":"medium_convergence_01358","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRK and CRKL each interact with more than one shared protein partner. Evidence concerning one shared entity reports that a kinase binding to the first SH3 do... | |
medium_convergence_01359 | LMO2 and MYB both interact with a specific transcription factor. Evidence indicates that RBTN1 and RBTN2 interact with leukemogenic bHLH proteins, specifically identifying TAL2 and LYL1 among them. Which protein, connected to this identified entity via an 'encodes' relationship, is the target of the interaction describ... | T-cell acute lymphocytic leukemia protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01359","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LMO2 and MYB both interact with a specific transcription factor. Evidence indicates that RBTN1 and RBTN2 interact with leukemogenic bHLH proteins, specifical... | |
medium_convergence_01360 | EP300 and XRCC6 share multiple interacting partners. One such shared partner is described in the following evidence: 'Herein, we report that this protein is a novel Ku70-interacting protein identified by yeast two-hybrid screening.' Which disease is associated with this specific entity via a biomarker relationship? | lung adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_01360","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and XRCC6 share multiple interacting partners. One such shared partner is described in the following evidence: 'Herein, we report that this protein is ... | |
medium_convergence_01361 | HSP90AA1 and PRKN (also known as PARK2) share multiple interacting partners. One specific shared partner is characterized by evidence stating that it forms a complex with several other nuclear receptors, basic helix-loop-helix/Per-Arnt-Sim proteins, and heat-shock protein 90 (HSP90). Which gene interacts with this spec... | RBM39 | Medium | convergence | {"qa_id":"medium_convergence_01361","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSP90AA1 and PRKN (also known as PARK2) share multiple interacting partners. One specific shared partner is characterized by evidence stating that it forms a... | |
medium_convergence_01362 | ATR and FAAP100 both interact with a specific gene product. Evidence indicates that this product forms a conserved DNA-remodeling complex with the histone-fold heterodimer MHF. Which gene does this product interact with? | TELO2 | Medium | convergence | {"qa_id":"medium_convergence_01362","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATR and FAAP100 both interact with a specific gene product. Evidence indicates that this product forms a conserved DNA-remodeling complex with the histone-fo... | |
medium_convergence_01363 | Bexarotene and Cimetidine both interact with a specific drug. Evidence indicates that Ketoconazole, erythromycin, and this specific drug inhibit the metabolism of newer hypnosedatives, thereby enhancing their sedative effects and suggesting that a dose reduction may be required. Which disease is this specific drug indi... | insomnia | Medium | convergence | {"qa_id":"medium_convergence_01363","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Bexarotene and Cimetidine both interact with a specific drug. Evidence indicates that Ketoconazole, erythromycin, and this specific drug inhibit the metaboli... | |
medium_convergence_01364 | CRK and ABL1 share common interaction partners. One such shared partner is a kinase that binds to the first SH3 domain of Crk and phosphorylates c-Crk on tyrosine 221 (Y221), an activity identified as c-Abl. Which disease is associated with this shared partner through genomic alterations? | MELAS syndrome | Medium | convergence | {"qa_id":"medium_convergence_01364","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CRK and ABL1 share common interaction partners. One such shared partner is a kinase that binds to the first SH3 domain of Crk and phosphorylates c-Crk on tyr... | |
medium_convergence_01365 | Human alphaherpesvirus 1 and Primate bocaparvovirus 1 are both reported to downregulate a specific gene. Evidence for this downregulation in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of approximately -1.197 and an adjusted p-value of 0.001288. Which disease is associated with genomic alt... | myelomeningocele | Medium | convergence | {"qa_id":"medium_convergence_01365","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Primate bocaparvovirus 1 are both reported to downregulate a specific gene. Evidence for this downregulation in a monocytic leuk... | |
medium_convergence_01366 | Both IPO7 and KPNB1 interact with a common protein partner. Experimental evidence for this partner indicates that it forms stable complexes with several importins (including importin-β, importin-7, importin-β/7, importin-13, and transportin 1) and is imported into the nucleus in digitonin-permeabilized cells by these f... | Nitric oxide synthase-interacting protein | Medium | convergence | {"qa_id":"medium_convergence_01366","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both IPO7 and KPNB1 interact with a common protein partner. Experimental evidence for this partner indicates that it forms stable complexes with several impo... | |
medium_convergence_01367 | TSG101 and UBB both interact with a specific protein. Evidence regarding this protein states: 'The ability of HCRP1 (which we assign the alternative name hVps37A) to interact with Tsg101 is conferred by its mod(r) domain and is shared with hVps37B and hVps37C, two other mod(r) domain-containing proteins.' Which cell ty... | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_01367","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TSG101 and UBB both interact with a specific protein. Evidence regarding this protein states: 'The ability of HCRP1 (which we assign the alternative name hVp... | |
medium_convergence_01368 | Both the regulation of mast cell apoptotic process and the regulation of neutrophil apoptotic process are subtypes of a shared biological process. Evidence regarding this shared entity states: 'Any process that modulates the frequency, rate, or extent of mast cell apoptotic process.' Which biological process is directl... | leukocyte apoptotic process | Medium | convergence | {"qa_id":"medium_convergence_01368","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both the regulation of mast cell apoptotic process and the regulation of neutrophil apoptotic process are subtypes of a shared biological process. Evidence r... | |
medium_convergence_01369 | Aldesleukin and Bleomycin share a common interacting drug. Evidence regarding this shared entity indicates that synergism between the drugs when administered concurrently produces pulmonary toxicity at lower doses. Which disease is this shared drug indicated for? | lymphosarcoma | Medium | convergence | {"qa_id":"medium_convergence_01369","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Aldesleukin and Bleomycin share a common interacting drug. Evidence regarding this shared entity indicates that synergism between the drugs when administered... | |
medium_convergence_01370 | Neurturin (NRTN) and GAB2 both interact with a specific shared protein. Evidence states: 'Here we report that neurturin can bind to either GFRalpha-1 or GFRalpha-2, a novel receptor related to GFRalpha-1.' Based on this evidence, which of the shared interaction partners is identified, and what is the name of the protei... | GDNF family receptor alpha-2 | Medium | convergence | {"qa_id":"medium_convergence_01370","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Neurturin (NRTN) and GAB2 both interact with a specific shared protein. Evidence states: 'Here we report that neurturin can bind to either GFRalpha-1 or GFRa... | |
medium_convergence_01371 | Aldesleukin and Mitomycin both interact with a specific shared drug. Clinical evidence for this shared drug describes a regimen involving continuous infusion of the drug (0.20 mg/kg per day) combined with leucovorin (7.5 mg/m2/day) and dexamethasone (20 mg on days 1 to 14), along with a bolus of Mitomycin C (10 mg/m2 o... | liver cancer | Medium | convergence | {"qa_id":"medium_convergence_01371","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Aldesleukin and Mitomycin both interact with a specific shared drug. Clinical evidence for this shared drug describes a regimen involving continuous infusion... | |
medium_convergence_01372 | ESRRG and HDAC1 share a common interaction partner. Evidence regarding this partner states: 'Interestingly, yeast two-hybrid and glutathione-S-transferase pull-down assays demonstrated that wild-type and [the protein encoded by NR0B2] Delta128-139 have similar abilities to interact with estrogen receptor-related recept... | Nuclear receptor subfamily 0 group B member 2 | Medium | convergence | {"qa_id":"medium_convergence_01372","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESRRG and HDAC1 share a common interaction partner. Evidence regarding this partner states: 'Interestingly, yeast two-hybrid and glutathione-S-transferase pu... | |
medium_convergence_01373 | Serotonin binding and histamine binding share a common molecular function category. Evidence regarding one shared entity notes: 'Binding to serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.' Which molecular function is... | ion binding | Medium | convergence | {"qa_id":"medium_convergence_01373","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Serotonin binding and histamine binding share a common molecular function category. Evidence regarding one shared entity notes: 'Binding to serotonin (5-hydr... | |
medium_convergence_01374 | CEBPB and XRCC6 share a common interaction partner. Evidence regarding one such partner states: 'We show that HMGI-Y physically interacts with Sp1 and C/EBP beta and facilitates the binding of both factors to the IR promoter in vitro.' Which cell type is enriched for this specific interaction partner? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_01374","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CEBPB and XRCC6 share a common interaction partner. Evidence regarding one such partner states: 'We show that HMGI-Y physically interacts with Sp1 and C/EBP ... | |
medium_convergence_01375 | Both Human alphaherpesvirus 1 and Rift Valley fever phlebovirus are known to upregulate a specific shared gene. Experimental data for this gene, derived from a foreskin fibroblast cell line, reports a log2 fold change of approximately 1.555 and an adjusted p-value of 0.04968. In which cellular component is this gene pr... | mitochondrion | Medium | convergence | {"qa_id":"medium_convergence_01375","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Rift Valley fever phlebovirus are known to upregulate a specific shared gene. Experimental data for this gene, derived from... | |
medium_convergence_01376 | IRS1 and PTK2 share multiple interacting partners. One such partner is implicated in a study where treatment of C57MG cells with insulin resulted in the binding of p55PIK, but not p50PIK, to insulin receptor substrate-1, suggesting distinct roles for different p55PIK forms in signal transduction. Which cell type is enr... | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_01376","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IRS1 and PTK2 share multiple interacting partners. One such partner is implicated in a study where treatment of C57MG cells with insulin resulted in the bind... | |
medium_convergence_01377 | PARP1 and SMAD7 share a common interacting partner. Evidence indicates that a protein complex involving this shared entity and histone deacetylase binds to the promoter region of TGF-beta1 responsive genes containing the Smad-responsive element (SRE) to inhibit TGF-beta1 signaling. However, ectopic expression of this s... | Zinc finger E-box-binding homeobox 1 | Medium | convergence | {"qa_id":"medium_convergence_01377","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and SMAD7 share a common interacting partner. Evidence indicates that a protein complex involving this shared entity and histone deacetylase binds to t... | |
medium_convergence_01381 | HSPA8 and DNAJB1 both interact with a specific protein. Evidence regarding this protein states: 'Analyses of the cotransporter immunoprecipitates revealed that it formed complexes with the core chaperones Hsp90, Hsp70, and Hsp40.' Which protein is encoded by the gene corresponding to this interacting partner? | Solute carrier family 12 member 3 | Medium | convergence | {"qa_id":"medium_convergence_01381","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA8 and DNAJB1 both interact with a specific protein. Evidence regarding this protein states: 'Analyses of the cotransporter immunoprecipitates revealed th... | |
medium_convergence_01382 | TOPBP1 and MYC share multiple interacting partners. One such shared partner has been reported to directly interact with the DNA repair scaffold protein TOPBP1. Which cellular component is this shared partner located in? | chromosome | Medium | convergence | {"qa_id":"medium_convergence_01382","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TOPBP1 and MYC share multiple interacting partners. One such shared partner has been reported to directly interact with the DNA repair scaffold protein TOPBP... | |
medium_convergence_01384 | Rhinovirus A and Zika virus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of 1.822 and an adjusted p-value of 0.0269. Which protein is encoded by this gene? | Cyclin-dependent kinase 4 inhibitor B | Medium | convergence | {"qa_id":"medium_convergence_01384","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Zika virus both upregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2... | |
medium_convergence_01385 | LMNA and SYCP3 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Moreover, we show that myne-1 and lamin A/C coimmunoprecipitate from differentiated muscle in vitro.' Which disease is connected to that specific shared protein partner through genomic alter... | colorectal carcinoma | Medium | convergence | {"qa_id":"medium_convergence_01385","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"LMNA and SYCP3 each interact with more than one shared protein partner. Evidence concerning one of these shared partners states: 'Moreover, we show that myne... | |
medium_convergence_01386 | CDC37 and EGFR share multiple interacting partners. One such partner is implicated in a study where ansamycin treatment decreased its association with cdc2 and p50 (an Hsp90 co-chaperone), while increasing its interaction with an Hsp70 co-chaperone. Which protein is encoded by this shared interacting partner? | M-phase inducer phosphatase 3 | Medium | convergence | {"qa_id":"medium_convergence_01386","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDC37 and EGFR share multiple interacting partners. One such partner is implicated in a study where ansamycin treatment decreased its association with cdc2 a... | |
medium_convergence_01387 | MTOR and ATP6V1D share multiple binding partners. One shared partner is described as interacting with a regulatory-associated protein of mTOR and GbetaL to form a complex that serves as the target of rapamycin. Which protein is encoded by the gene corresponding to this shared partner? | Regulatory-associated protein of mTOR | Medium | convergence | {"qa_id":"medium_convergence_01387","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MTOR and ATP6V1D share multiple binding partners. One shared partner is described as interacting with a regulatory-associated protein of mTOR and GbetaL to f... | |
medium_convergence_01388 | Human polyomavirus 1 and Measles morbillivirus both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) reports a log2 fold change of approximately 1.91 and an adjusted p-value of 0.0033. Which protein is encoded by this gene? | Ras-responsive element-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01388","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human polyomavirus 1 and Measles morbillivirus both upregulate a specific gene. Experimental data for this gene in renal epithelial cells (study GSE135833) r... | |
medium_convergence_01389 | MYC and RNF4 both interact with a specific shared protein. Evidence indicates that this shared protein binds, ubiquitinates, and stabilizes phosphorylated eIF2α (p-eIF2α), but does not interact with activating transcription factor 4 or C/EBP homologous protein, which are mediators of the eIF2α-dependent integrated stre... | Eukaryotic translation initiation factor 2A | Medium | convergence | {"qa_id":"medium_convergence_01389","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MYC and RNF4 both interact with a specific shared protein. Evidence indicates that this shared protein binds, ubiquitinates, and stabilizes phosphorylated eI... | |
medium_convergence_01390 | ATF7IP and H3C1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Immunoprecipitation and in vitro binding analyses reveal that both MCAF proteins interact with MBD1, this shared protein, and Sp1 via two evolutionarily conserved distinct domains.' Which protein is connecte... | Histone-lysine N-methyltransferase SETDB1 | Medium | convergence | {"qa_id":"medium_convergence_01390","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATF7IP and H3C1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Immunoprecipitation and in vitro binding ana... | |
medium_convergence_01392 | PRPF8 and RUVBL2 both interact with a shared protein. Evidence indicates that the zinc-finger HIT domain has a general function in binding this shared entity. Which protein is encoded by the gene corresponding to this shared entity? | Zinc finger HIT domain-containing protein 2 | Medium | convergence | {"qa_id":"medium_convergence_01392","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRPF8 and RUVBL2 both interact with a shared protein. Evidence indicates that the zinc-finger HIT domain has a general function in binding this shared entity... | |
medium_convergence_01393 | HDAC2 and RBBP4 each interact with more than one shared protein partner. Evidence concerning one such shared partner reports that Myt1 complexes were co-immunoprecipitated from transfected mammalian cells and included HDAC1 and HDAC2. Which protein is encoded by that shared partner? | Paired amphipathic helix protein Sin3b | Medium | convergence | {"qa_id":"medium_convergence_01393","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC2 and RBBP4 each interact with more than one shared protein partner. Evidence concerning one such shared partner reports that Myt1 complexes were co-immu... | |
medium_convergence_01394 | Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experimental data for this gene in a lung fibroblast cell line (study GSE120891) reports a log2 fold change of approximately -1.186 and an adjusted p-value of approximately 0.... | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_01394","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human mastadenovirus C and Severe acute respiratory syndrome-related coronavirus are associated with the downregulation of a specific gene. Experimental... | |
medium_convergence_01395 | YWHAQ and MKRN1 both interact with a shared protein. Evidence regarding one of these shared partners states: 'Here we showed that MKRN1, an E3 ligase, could directly interact with and ubiquitylate this partner, promoting its proteasomal degradation.' Which protein is encoded by the gene corresponding to this shared par... | Adenomatous polyposis coli protein | Medium | convergence | {"qa_id":"medium_convergence_01395","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAQ and MKRN1 both interact with a shared protein. Evidence regarding one of these shared partners states: 'Here we showed that MKRN1, an E3 ligase, could ... | |
medium_convergence_01396 | CASP10 and TNFSF10 both interact with multiple shared receptors. One such shared receptor is described by evidence stating that TRAIL binds to recombinant cell-surface-expressed TNFRSF10B, and that TRAIL-induced apoptosis is inhibited by a TNFRSF10B-Fc fusion protein. Which protein is encoded by this specific receptor? | Tumor necrosis factor receptor superfamily member 10B | Medium | convergence | {"qa_id":"medium_convergence_01396","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CASP10 and TNFSF10 both interact with multiple shared receptors. One such shared receptor is described by evidence stating that TRAIL binds to recombinant ce... | |
medium_convergence_01397 | Somatotropin and Betamethasone share a common interacting drug. Clinical evidence regarding this shared drug describes the combined effects of growth hormone and its replacement treatment in heart failure. Which disease is this shared drug indicated for? | hypogonadotropic hypogonadism | Medium | convergence | {"qa_id":"medium_convergence_01397","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Somatotropin and Betamethasone share a common interacting drug. Clinical evidence regarding this shared drug describes the combined effects of growth hormone... | |
medium_convergence_01398 | Human mastadenovirus C and Primate bocaparvovirus 1 are both reported to upregulate a specific gene. Experimental data for this gene in lung fibroblast cell lines (study GSE120891) indicates a log2 fold change of approximately 1.465 and an adjusted p-value of 0.03813. Which protein is encoded by this gene? | Guanine nucleotide-binding protein subunit beta-like protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01398","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human mastadenovirus C and Primate bocaparvovirus 1 are both reported to upregulate a specific gene. Experimental data for this gene in lung fibroblast cell ... | |
medium_convergence_01399 | Vaccinia virus and Dengue virus both downregulate the expression of a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE11238) indicates that for one such shared target, the log2 fold change is -3.671 and the adjusted p-value is 0.02105. Which protein is encoded by this gene? | Protein yippee-like 5 | Medium | convergence | {"qa_id":"medium_convergence_01399","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Vaccinia virus and Dengue virus both downregulate the expression of a specific gene. Experimental data from a cervical adenocarcinoma cell line (study GSE112... | |
medium_convergence_01400 | CSNK1G3 and CTNNB1 share a common binding partner. Evidence indicates that this shared entity, also known as a specific F-box protein, functions as part of the SCF complex with Skp1 and Cullin1, specifically interacting with phosphorylated IkappaB and beta-catenin to target them for proteasome-dependent degradation in ... | neurodevelopmental, jaw, eye, and digital syndrome | Medium | convergence | {"qa_id":"medium_convergence_01400","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK1G3 and CTNNB1 share a common binding partner. Evidence indicates that this shared entity, also known as a specific F-box protein, functions as part of t... | |
medium_convergence_01401 | EIF2B4 and EIF2B2 are both involved in more than one shared biological process. One of these shared processes is linked to a specific entity by evidence stating: 'Recently, in seven patients who presented with POF and white matter abnormalities on MRI (ovarioleukodystrophy) eight mutations were found in EIF2B2, 4 and 5... | anatomical structure development | Medium | convergence | {"qa_id":"medium_convergence_01401","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF2B4 and EIF2B2 are both involved in more than one shared biological process. One of these shared processes is linked to a specific entity by evidence stat... | |
medium_convergence_01402 | ASF1A and H3F3B both interact with a common protein partner. Experimental evidence indicates that hAsf1 proteins interact directly with the p60 subunit of hCAF-1. Which protein is encoded by this shared partner? | Chromatin assembly factor 1 subunit B | Medium | convergence | {"qa_id":"medium_convergence_01402","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ASF1A and H3F3B both interact with a common protein partner. Experimental evidence indicates that hAsf1 proteins interact directly with the p60 subunit of hC... | |
medium_convergence_01403 | PARP1 and HDAC2 share multiple interacting partners. One such partner is described in evidence stating: 'Mechanistic analysis further showed that it specifically interacts with poly(ADP-ribose) polymerase-1 (PARP-1), a nuclear enzyme important in DNA repair and apoptosis.' Which cell type is this specific partner enric... | basophil | Medium | convergence | {"qa_id":"medium_convergence_01403","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PARP1 and HDAC2 share multiple interacting partners. One such partner is described in evidence stating: 'Mechanistic analysis further showed that it specific... | |
medium_convergence_01404 | ARRB2 and GNG12 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In vitro data from glutathione-S-transferase pull-down assay showed that the carboxyl terminus (CT) and the third intracellular loop (I3L) of DOR are both capable of and either domain is sufficient for bindi... | Delta-type opioid receptor | Medium | convergence | {"qa_id":"medium_convergence_01404","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARRB2 and GNG12 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'In vitro data from glutathione-S-transferase... | |
medium_convergence_01405 | CREBBP and HDAC1 share multiple interacting partners. One such partner is described in a study using mass spectrometry to identify nuclear and cytoplasmic CBP-interacting proteins, which identified a specific protein as a stoichiometric CBP-interacting protein that negatively regulates CBP-dependent p53 polyubiquitinat... | Wallerian degeneration | Medium | convergence | {"qa_id":"medium_convergence_01405","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and HDAC1 share multiple interacting partners. One such partner is described in a study using mass spectrometry to identify nuclear and cytoplasmic CB... | |
medium_convergence_01406 | EIF4G1 and NCBP2 share multiple protein interaction partners. One specific shared partner is characterized by experimental evidence stating: 'Co-immunoprecipitation experiments showed that the extended eIF4GI binds PABP, while the N-terminally truncated original eIF4GI cannot.' Which protein is encoded by the gene corr... | Polyadenylate-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_01406","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF4G1 and NCBP2 share multiple protein interaction partners. One specific shared partner is characterized by experimental evidence stating: 'Co-immunoprecip... | |
medium_convergence_01407 | CLU and HSP90AA1 share multiple interacting partners. One such shared partner is known to interact with both type I and type II TGF-beta receptors, but not with the epidermal growth factor (EGF) receptor. Which disease is genetically associated with this specific shared partner? | coronary aneurysm | Medium | convergence | {"qa_id":"medium_convergence_01407","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CLU and HSP90AA1 share multiple interacting partners. One such shared partner is known to interact with both type I and type II TGF-beta receptors, but not w... | |
medium_convergence_01408 | GTF3C4 and GTF3C3 each interact with more than one shared protein partner. Evidence concerning one such shared partner reports: 'These include novel interactions of hTFIIIC63 with hTFIIIC102, with hTFIIIB90, and with hRPC62, in addition to the hTFIIIC102-hTFIIIB90 and hTFIIIB90-hRPC39 interactions that parallel the pre... | DNA-directed RNA polymerase III subunit RPC3 | Medium | convergence | {"qa_id":"medium_convergence_01408","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GTF3C4 and GTF3C3 each interact with more than one shared protein partner. Evidence concerning one such shared partner reports: 'These include novel interact... | |
medium_convergence_01409 | Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are reported to downregulate a specific gene. In a study using a melanoma cell line (GSE136586), this gene exhibited a log2 fold change of approximately -1.098 and an adjusted p-value of 0.0001423. Which protein is encoded by this g... | Heparan sulfate glucosamine 3-O-sulfotransferase 1 | Medium | convergence | {"qa_id":"medium_convergence_01409","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 3 and Severe acute respiratory syndrome-related coronavirus are reported to downregulate a specific gene. In a study using a mela... | |
medium_convergence_01410 | DBF4 and CDC7 both interact with a specific shared protein. Evidence regarding this interaction states: 'We also identified an interaction between MCM-BP and the Dbf4 regulatory component of the DDK kinase in both yeast 2-hybrid and insect cell co-expression assays, and this interaction was verified by co-immunoprecipi... | DNA replication licensing factor MCM4 | Medium | convergence | {"qa_id":"medium_convergence_01410","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DBF4 and CDC7 both interact with a specific shared protein. Evidence regarding this interaction states: 'We also identified an interaction between MCM-BP and... | |
medium_convergence_01411 | HECTD1 and PRKN (PARK2) share common interaction partners. One such shared partner is described as an assembly factor for the ribosomal 60S subunit that is ubiquitinated and degraded by HECTD1. Which protein is encoded by this shared partner? | Cytoplasmic 60S subunit biogenesis factor ZNF622 | Medium | convergence | {"qa_id":"medium_convergence_01411","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HECTD1 and PRKN (PARK2) share common interaction partners. One such shared partner is described as an assembly factor for the ribosomal 60S subunit that is u... | |
medium_convergence_01412 | AKT1 and PRKN each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'We found that the C-terminal region of protein kinase C-related kinase 2, containing amino acids 862 to 908, specifically binds to Akt in yeast and mammalian cells.' Which protein is encoded by that entit... | Serine/threonine-protein kinase N2 | Medium | convergence | {"qa_id":"medium_convergence_01412","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKT1 and PRKN each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'We found that the C-terminal region of pr... | |
medium_convergence_01413 | YWHAQ and MAPT both interact with a shared protein. Evidence regarding this shared entity states: 'We have shown recently that a novel protein kinase, termed p110 microtubule-affinity regulating kinase, phosphorylates microtubule-associated protein tau at the KXGS motifs in the region of internal repeats and causes the... | Serine/threonine-protein kinase MARK1 | Medium | convergence | {"qa_id":"medium_convergence_01413","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAQ and MAPT both interact with a shared protein. Evidence regarding this shared entity states: 'We have shown recently that a novel protein kinase, termed... | |
medium_convergence_01415 | YWHAQ and CUL9 both interact with a specific shared protein. Evidence indicates that when this protein is dephosphorylated at serine 246, it is efficiently recruited to clathrin-coated pits (CCPs); however, upon phosphorylation by Akt, it is sequestered by 14-3-3 adaptors and excluded from CCPs. Which gene encodes this... | SH3 domain-binding protein 4 | Medium | convergence | {"qa_id":"medium_convergence_01415","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YWHAQ and CUL9 both interact with a specific shared protein. Evidence indicates that when this protein is dephosphorylated at serine 246, it is efficiently r... | |
medium_convergence_01416 | CTNNB1 and PRKN share multiple interacting partners. One such shared partner is described in the following evidence: 'Here, we show that cell cycle and apoptosis regulator 1, which was recently shown to function as a transcriptional coactivator for nuclear receptors, also interacts with beta-catenin and enhances the ab... | nuclear envelope lumen | Medium | convergence | {"qa_id":"medium_convergence_01416","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and PRKN share multiple interacting partners. One such shared partner is described in the following evidence: 'Here, we show that cell cycle and apopt... | |
medium_convergence_01417 | ALK and PRNP both interact with a shared protein. Evidence indicates that the interaction between this shared protein and a tyrosine phosphatase, as well as the phosphorylation of this tyrosine phosphatase at tyrosine 542, is dependent on the activation of this shared protein. Which protein is encoded by the gene corre... | Tyrosine-protein phosphatase non-receptor type 11 | Medium | convergence | {"qa_id":"medium_convergence_01417","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ALK and PRNP both interact with a shared protein. Evidence indicates that the interaction between this shared protein and a tyrosine phosphatase, as well as ... | |
medium_convergence_01418 | Both Human orthopneumovirus and Influenza A virus are known to upregulate a specific shared gene. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately 1.738 and an adjusted p-value of 0.03048. Which cellular component is this gene located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_01418","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human orthopneumovirus and Influenza A virus are known to upregulate a specific shared gene. Experimental data for this gene in cytotoxic T-lymphocytes ... | |
medium_convergence_01419 | Both Measles morbillivirus and Rhinovirus A are reported to downregulate a specific gene. Experimental data for this gene from study GSE131840 indicates a log2 fold change of -1.080 and an adjusted p-value of 0.001632. Which disease is associated with this gene? | galactosemia 4 | Medium | convergence | {"qa_id":"medium_convergence_01419","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Measles morbillivirus and Rhinovirus A are reported to downregulate a specific gene. Experimental data for this gene from study GSE131840 indicates a lo... | |
medium_convergence_01420 | EGFR and PTPN6 share a common interaction partner. Contextual evidence indicates that this shared partner is a Src-related kinase that associates with the adaptor protein Grb2, as well as with SHP1 and SHP2. Which protein is encoded by the gene corresponding to this shared partner? | Tyrosine-protein kinase SYK | Medium | convergence | {"qa_id":"medium_convergence_01420","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and PTPN6 share a common interaction partner. Contextual evidence indicates that this shared partner is a Src-related kinase that associates with the ad... | |
medium_convergence_01421 | Both Human respirovirus 3 and Zika virus are reported to downregulate a specific gene. Experimental data for this gene in a non-small cell lung adenocarcinoma cell line (study GSE147507) shows a log2 fold change of approximately -1.458 and an adjusted p-value of 0.04216. Which disease is associated with this gene? | fibrosarcoma | Medium | convergence | {"qa_id":"medium_convergence_01421","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human respirovirus 3 and Zika virus are reported to downregulate a specific gene. Experimental data for this gene in a non-small cell lung adenocarcinom... | |
medium_convergence_01422 | PLK3 and PARP1 both physically interact with a specific shared protein partner. Experimental evidence indicates that this shared partner physically interacts with HIF-1α under hypoxic conditions, as revealed by immunoprecipitation and pulldown analyses. Which protein is encoded by the gene corresponding to this shared ... | Hypoxia-inducible factor 1-alpha | Medium | convergence | {"qa_id":"medium_convergence_01422","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PLK3 and PARP1 both physically interact with a specific shared protein partner. Experimental evidence indicates that this shared partner physically interacts... | |
medium_convergence_01423 | H2AX and HIST3H3 each share a binding partner. Evidence concerning one shared entity reports that gammaH2AX serves as a marker for DNA repair and active [a serine/threonine kinase] interacts with gammaH2AX in actinomycin D-treated mitotic extracts. Which protein is connected to that entity through the 'encodes' relatio... | Mitogen-activated protein kinase 8 | Medium | convergence | {"qa_id":"medium_convergence_01423","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"H2AX and HIST3H3 each share a binding partner. Evidence concerning one shared entity reports that gammaH2AX serves as a marker for DNA repair and active [a s... | |
medium_convergence_01424 | YAP1 and SERBP1 share common interaction partners. One such partner is implicated in a study stating: 'In this study, we find that the interaction between this partner and YAP is critical for liver cancer cell proliferation and maintenance of transformed phenotypes both in vitro and in vivo.' Which protein is encoded b... | Dual specificity mitogen-activated protein kinase kinase 1 | Medium | convergence | {"qa_id":"medium_convergence_01424","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"YAP1 and SERBP1 share common interaction partners. One such partner is implicated in a study stating: 'In this study, we find that the interaction between th... | |
medium_convergence_01425 | IL1A and IL1R1 each interact with more than one shared protein. Evidence concerning one shared entity reports that IL-1 treatment of cells induces the formation of a complex containing both IL-1RI and the protein encoded by the shared entity. Which protein is connected to that entity through the 'encodes' relationship? | Interleukin-1 receptor accessory protein | Medium | convergence | {"qa_id":"medium_convergence_01425","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IL1A and IL1R1 each interact with more than one shared protein. Evidence concerning one shared entity reports that IL-1 treatment of cells induces the format... | |
medium_convergence_01426 | CTBP1 and CTNNB1 share a common interaction partner. Evidence regarding this shared partner indicates that Polycomb group proteins HPC2 and BMI-1, along with the corepressor C-terminal-binding protein, bind to the repression domain of this partner. Which protein is encoded by this shared interaction partner? | Histone-lysine N-methyltransferase 2A | Medium | convergence | {"qa_id":"medium_convergence_01426","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTBP1 and CTNNB1 share a common interaction partner. Evidence regarding this shared partner indicates that Polycomb group proteins HPC2 and BMI-1, along with... |
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