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medium_hidden_intermediate_06526 | Two genes are upregulated by Human immunodeficiency virus 1 and are located in focal adhesions. One of these genes exhibits a log2 fold change of approximately 1.397 and an adjusted p-value of 0.01319 in macrophages. Which disease is associated with this specific gene as a biomarker? | hepatocellular carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06526","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and are located in focal adhesions. One of these genes exhibits ... | |
medium_hidden_intermediate_06530 | Two distinct drugs are known to interact with both Warfarin and Encorafenib. Clinical evidence regarding one of these drugs describes a probable interaction with Warfarin in a patient being treated for small intestine bacterial overgrowth. Which disease is the drug associated with this specific clinical scenario indica... | diarrheal disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06530","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct drugs are known to interact with both Warfarin and Encorafenib. Clinical evidence regarding one of these drugs ... | |
medium_hidden_intermediate_06531 | Pegivirus C downregulates a gene that participates in the metabolism of carbohydrates and carbohydrate derivatives. Experimental data from peripheral blood mononuclear cells (study GSE131504) indicates that this specific gene has a log2 fold change of approximately -1.13 and an adjusted p-value of approximately 0.0027.... | deoxyribonucleoside catabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06531","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that participates in the metabolism of carbohydrates and carbohydrate derivatives. Experime... | |
medium_hidden_intermediate_06533 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with PABPC1. One of these genes shows a log2 fold change of 1.139 and an adjusted p-value of 0.0008893 in a specific study. Which protein is encoded by this gene? | E3 ubiquitin-protein ligase makorin-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06533","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with PABPC1. One of these ge... | |
medium_hidden_intermediate_06534 | Enterovirus A is known to downregulate certain genes that enable RNA binding. One such gene, identified in a study of rhabdomyosarcoma cells (GSE103308), exhibits a log2 fold change of approximately -1.229 and an adjusted p-value of 0.001288. Which cellular component is this specific gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06534","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is known to downregulate certain genes that enable RNA binding. One such gene, identified in a study of rhabdo... | |
medium_hidden_intermediate_06535 | Human alphaherpesvirus 3 is known to upregulate a gene that participates in the differentiation of T cells. In a study of melanoma cell lines (GSE136586), one such gene was found to have a log2 fold change of 1.303 and an adjusted p-value of 2.1e-08. Which protein is encoded by this specific gene? | Mastermind-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06535","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 is known to upregulate a gene that participates in the differentiation of T cells. In a study of me... | |
medium_hidden_intermediate_06538 | Hepacivirus C is reported to downregulate a specific gene that participates in the metabolism of carbohydrates and carbohydrate derivatives. Experimental data for this gene in peripheral blood mononuclear cells (study GSE119117) show a log2 fold change of -1.718 and an adjusted p-value of 0.01903. Which disease is asso... | Larsen-like syndrome, B3GAT3 type | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06538","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a specific gene that participates in the metabolism of carbohydrates and carbohydr... | |
medium_hidden_intermediate_06541 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the RAC1 GTPase cycle. One of these genes exhibits a log2 fold change of approximately 2.85 and an adjusted p-value of approximately 0.006 in lung cells. Which cellular component is the location of this specific gene? | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06541","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in the RAC1 GTPase cycle.... | |
medium_hidden_intermediate_06542 | A specific genetic variant, NM_015600.4(ABHD12):c.-6898_191+7002delinsCC, is linked to a gene that is associated with carcinoma. Evidence regarding this gene indicates that treated carcinomas exhibit reduced levels of a specific transcription factor and reduced phosphorylated ERK, without changes in phosphorylated MEK.... | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06542","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A specific genetic variant, NM_015600.4(ABHD12):c.-6898_191+7002delinsCC, is linked to a gene that is associated with carcin... | |
medium_hidden_intermediate_06543 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which in turn encodes a protein that binds to RFC4. This gene exhibited a log2 fold change of 3.403 and an adjusted p-value of 2.409e-09. Which protein is encoded by this upregulated gene? | Flap endonuclease 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06543","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_06544 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which in turn interacts with PPFIA1. This gene exhibited a log2 fold change of approximately 1.22 and an adjusted p-value of 0.0026. Which protein is encoded by this gene? | Inhibitor of growth protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06544","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_06547 | Hepacivirus C downregulates a gene that enables single-stranded DNA binding. In a study of peripheral blood mononuclear cells (GSE119117), one such gene exhibits a log2 fold change of -1.737 and an adjusted p-value of 0.004303. Which cellular component is this gene located in? | Shu complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06547","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that enables single-stranded DNA binding. In a study of peripheral blood mononuclear cell... | |
medium_hidden_intermediate_06548 | Pegivirus C downregulates multiple genes that participate in the biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and its transfer to a nascent protein. One such gene exhibits a log2 fold change of -1.284 and an adjusted p-value of 0.0003019 in peripheral blood mononuclear cells. Whic... | N-acetylneuraminate catabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06548","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates multiple genes that participate in the biosynthesis of the N-glycan precursor (dolichol lipid-link... | |
medium_hidden_intermediate_06549 | Rhinovirus A infection is associated with the upregulation of specific genes that are enriched in basophils. One such gene exhibits a log2 fold change of approximately 1.079 and an adjusted p-value of 0.0168 in cytotoxic T-lymphocytes. Which protein is encoded by this gene? | UPF0450 protein C17orf58 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06549","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection is associated with the upregulation of specific genes that are enriched in basophils. One such gene e... | |
medium_hidden_intermediate_06550 | Human immunodeficiency virus 1 downregulates a gene that participates in GPCR downstream signalling. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of -2.651 and an adjusted p-value of 0.009557. Which protein is encoded by this gene? | Lysophosphatidic acid receptor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06550","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in GPCR downstream signalling. In a study of macrophag... | |
medium_hidden_intermediate_06551 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the downregulation of certain genes involved in protein metabolism. One such gene exhibits a log2 fold change of -3.496 and an adjusted p-value of 0.01717. Which protein is encoded by this specific gene? | Ras-related protein Rab-37 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06551","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection leads to the downregulation of certain gene... | |
medium_hidden_intermediate_06552 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to head and neck squamous cell carcinoma via association. One of these genes exhibits a log2 fold change of approximately 1.44 and an adjusted p-value of 0.0056 in a specific study. Which protein is encoded by this gene? | Anion exchange protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06552","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to head and neck squamous... | |
medium_hidden_intermediate_06554 | In the study GSE131840, Measles morbillivirus upregulates a specific gene that participates in Signaling by Receptor Tyrosine Kinases. This gene exhibits a log2 fold change of 1.959 and an adjusted p-value of 0.01386. Which protein does this gene product bind to? | SOX10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06554","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In the study GSE131840, Measles morbillivirus upregulates a specific gene that participates in Signaling by Receptor Tyrosin... | |
medium_hidden_intermediate_06555 | A gene is connected to GNAS via a binding interaction and is involved in the G protein-coupled receptor signaling pathway. Evidence for this gene states: 'We report the cloning of a novel human gene encoding a putative G-protein-coupled receptor (GPCR) of 356 amino acids and a related pseudogene.' Which molecular funct... | G protein-coupled receptor activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06555","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is connected to GNAS via a binding interaction and is involved in the G protein-coupled receptor signaling pathway. E... | |
medium_hidden_intermediate_06557 | In a study of Influenza A virus infection, a specific gene is upregulated by the virus and its protein product is located in extracellular exosomes. Evidence for this gene reports a log2 fold change of 1.614 and an adjusted p-value of 1.59e-08. Which disease is associated with genomic alterations in this gene? | morbid obesity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06557","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated by the virus and its protein product is located in... | |
medium_hidden_intermediate_06558 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that enables phosphate ion binding. One such gene exhibited a log2 fold change of 4.309 and an adjusted p-value of 6.874e-11. Which protein is encoded by this specific gene? | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06558","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that en... | |
medium_hidden_intermediate_06560 | Severe acute respiratory syndrome-related coronavirus upregulates multiple genes that are located in the lamellipodium. One such gene exhibits a log2 fold change of approximately 1.002 and an adjusted p-value of 5.386e-05. Which protein is encoded by this specific gene? | Diacylglycerol kinase zeta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06560","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates multiple genes that are located in the lamellipodium. One ... | |
medium_hidden_intermediate_06562 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Homology Directed Repair. Experimental data for this gene shows a log2 fold change of 2.118 and an adjusted p-value of 0.0146. Which protein is encoded by this gene? | Claspin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06562","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Homology Directed Repair.... | |
medium_hidden_intermediate_06563 | In a study of Measles morbillivirus infection, two genes are upregulated by the virus and localized to the perinuclear region of the cytoplasm. One of these genes exhibits a log2 fold change of approximately 1.407 and an adjusted p-value of 0.03705. Which protein does this specific gene interact with? | SUCLG2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06563","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, two genes are upregulated by the virus and localized to the perinuclear regio... | |
medium_hidden_intermediate_06564 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with SFXN1. One of these genes exhibits a log2 fold change of approximately 1.695 and an adjusted p-value of 0.03366 in a specific study. Which cellular component is the location of this specific gene? | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06564","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with SFXN1. One of these gen... | |
medium_hidden_intermediate_06565 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE155241), two genes involved in leukocyte cell-cell adhesion were found to be upregulated. One of these genes exhibited a log2 fold change of approximately 3.19 and an adjusted p-value of 0.02818. Which protein is encoded by... | Intercellular adhesion molecule 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06565","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE155241), two genes involved... | |
medium_hidden_intermediate_06566 | In a study of Influenza A virus infection, a specific gene is upregulated by the virus and its product interacts with MAP1LC3A. Experimental data for this gene reports a log2 fold change of 1.222 and an adjusted p-value of 1.627e-05. Which protein is encoded by this gene? | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06566","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated by the virus and its product interacts with MAP1LC... | |
medium_hidden_intermediate_06567 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to UBE2A via a 'binds' relationship. One of these genes is reported in a study (GSE164073) involving sclera cells, with a log2 fold change of approximately 4.14 and an adjusted p-value of 0.0... | anencephaly 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06567","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_06568 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for diabetic kidney disease. Evidence for this gene reports a log2 fold change of 1.179 and an adjusted p-value of 0.009882. Which protein is encoded by this gene? | D site-binding protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06568","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for diabetic kidney... | |
medium_hidden_intermediate_06569 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables calcium ion binding. Evidence for this gene reports a log2 fold change of 3.087 and an adjusted p-value of 0.007997. Which protein is encoded by this gene? | Calbindin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06569","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables calcium ion binding. Evidence for this... | |
medium_hidden_intermediate_06571 | Zika virus infection leads to the downregulation of certain genes that participate in the activation of the pre-replicative complex. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -1.678 and an adjusted p-value of 0.03178. Which protein is encoded by this specific gene? | DNA polymerase epsilon subunit 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06571","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection leads to the downregulation of certain genes that participate in the activation of the pre-replicative ... | |
medium_hidden_intermediate_06572 | Zika virus downregulates a specific gene that participates in mRNA splicing. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -1.665 and an adjusted p-value of 0.03034. Which protein is encoded by this gene? | Pre-mRNA-splicing factor SPF27 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06572","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in mRNA splicing. In a study of glioma stem cells (GSE114907), th... | |
medium_hidden_intermediate_06573 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that participates in Nucleotide salvage. This specific gene exhibited a log2 fold change of -1.102 and an adjusted p-value of 0.005962. Which protein does this gene interact with? | CDK1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06573","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a gene that participates in ... | |
medium_hidden_intermediate_06574 | Human alphaherpesvirus 3 upregulates a gene that participates in Signal Transduction. In a study of melanoma cell lines (GSE136586), one such gene showed a log2 fold change of approximately 1.13 and an adjusted p-value of 0.0003466. Which gene interacts with this specific upregulated gene? | CREB5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06574","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 upregulates a gene that participates in Signal Transduction. In a study of melanoma cell lines (GSE... | |
medium_hidden_intermediate_06575 | A gene is downregulated by Cardiovirus A and enables histone reader activity. In a study of cervical adenocarcinoma cell lines (GSE122967), this gene exhibits a log2 fold change of approximately -1.84 and an adjusted p-value of approximately 0.028. Which disease is associated with this gene as a biomarker? | intellectual disability | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06575","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Cardiovirus A and enables histone reader activity. In a study of cervical adenocarcinoma cell lin... | |
medium_hidden_intermediate_06576 | Enterovirus A is reported to upregulate a specific gene, the product of which is enriched in Mucosa-associated invariant T (MAIT) cells. In a study of rhabdomyosarcoma cells (GSE103308), this gene exhibited a log2 fold change of approximately 1.101 and an adjusted p-value of 0.002124. Which protein is encoded by this g... | UL16-binding protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06576","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to upregulate a specific gene, the product of which is enriched in Mucosa-associated invariant T (... | |
medium_hidden_intermediate_06577 | Pegivirus C is reported to downregulate a gene that enables single-stranded DNA binding. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -1.576 and an adjusted p-value of 0.001135. Which protein is encoded by this specific gene? | Far upstream element-binding protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06577","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that enables single-stranded DNA binding. In a study of peripheral blood mono... | |
medium_hidden_intermediate_06578 | Two genes are upregulated by Human immunodeficiency virus 1 and participate in the Innate Immune System. One of these genes exhibits a log2 fold change of approximately 1.108 and an adjusted p-value of 0.006416 in macrophages (study GSE108897). Which disease is associated with this specific gene? | glioma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06578","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and participate in the Innate Immune System. One of these genes ... | |
medium_hidden_intermediate_06579 | Vaccinia virus upregulates a gene that enables sequence-specific double-stranded DNA binding. In a study of cervical adenocarcinoma cell lines (GSE11238), one such gene showed a log2 fold change of 3.160 and an adjusted p-value of 0.0001265. Which disease is associated with this gene as a biomarker? | Huntington disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06579","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that enables sequence-specific double-stranded DNA binding. In a study of cervical adenoca... | |
medium_hidden_intermediate_06580 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables GTPase activator activity. In a study of lung cells, this gene showed a log2 fold change of 3.579 and an adjusted p-value of 0.001698. Which protein is encoded by this gene? | Cdc42 effector protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06580","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables GTPase activator activity. In a study ... | |
medium_hidden_intermediate_06581 | Rhinovirus A downregulates a specific gene that participates in the Adaptive Immune System. Experimental data for this gene shows a log2 fold change of approximately -1.68 and an adjusted p-value of 0.002981. Which cell type is this gene enriched in? | mucosal-associated invariant T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06581","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A downregulates a specific gene that participates in the Adaptive Immune System. Experimental data for this gene ... | |
medium_hidden_intermediate_06582 | Two genes are linked to Vaccinia virus via upregulation and to neuroblastoma as biomarkers. One of these genes exhibits a log2 fold change of 1.537 and an adjusted p-value of 2.644e-06 in cervical adenocarcinoma cell lines (study GSE11238). Which protein is encoded by this specific gene? | Ribosomal oxygenase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06582","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Vaccinia virus via upregulation and to neuroblastoma as biomarkers. One of these genes exhibits a lo... | |
medium_hidden_intermediate_06584 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in neutrophil chemotaxis. Evidence for one such gene reports a log2 fold change of 1.656 and an adjusted p-value of 0.02818. Which protein is encoded by that gene? | Junctional adhesion molecule-like | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06584","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in neutrophil chemotaxis. Evidence... | |
medium_hidden_intermediate_06586 | Two genes are structurally linked to Zika virus via downregulation and to Leishmania phagocytosis via participation. One of these genes exhibits a log2 fold change of approximately -1.166 and an adjusted p-value of 0.01092 in glioma stem cells. Which protein interacts with this specific gene? | TRIP10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06586","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Zika virus via downregulation and to Leishmania phagocytosis via participation. One of ... | |
medium_hidden_intermediate_06587 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with PIAS2. One of these genes shows a log2 fold change of 1.425 and an adjusted p-value of 0.02534 in a specific study. Which protein is encoded by this gene? | Zinc finger protein RFP | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06587","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with PIAS2. One of these gen... | |
medium_hidden_intermediate_06588 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus was found to downregulate a gene that participates in the Generic Transcription Pathway. One such gene exhibited a log2 fold change of -1.246 and an adjusted p-value of 4.845e-05. Which protein is encoded by this specific gene? | Tumor necrosis factor receptor superfamily member 10C | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06588","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus was found to downregulate a gene that participat... | |
medium_hidden_intermediate_06589 | A gene is upregulated by Human gammaherpesvirus 8 and participates in the metabolism of proteins. Experimental data for this gene in a non-Hodgkin lymphoma cell line (study GSE119608) reports a log2 fold change of approximately 1.57 and an adjusted p-value of 0.0167. Which protein does this gene interact with? | MSTN | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06589","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human gammaherpesvirus 8 and participates in the metabolism of proteins. Experimental data for this... | |
medium_hidden_intermediate_06592 | Human immunodeficiency virus 1 downregulates a gene that is located on the cytoplasmic side of the plasma membrane. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of -1.235 and an adjusted p-value of 0.0009842. Which protein is encoded by this gene? | Sorting nexin-18 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06592","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is located on the cytoplasmic side of the plasma membrane. In a stu... | |
medium_hidden_intermediate_06593 | Pegivirus C is reported to downregulate a specific gene that participates in gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation. Experimental data for this gene indicates a log2 fold change of -2.126 and an adjusted p-value of 0.01743. In which cell type is this gene enriched? | naive thymus-derived CD8-positive, alpha-beta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06593","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene that participates in gamma carboxylation, hypusinylation, hydroxylat... | |
medium_hidden_intermediate_06594 | Zika virus upregulates a specific gene, which in turn participates in the function of UCH proteinases. Experimental data from neural stem cells (study GSE129180) indicates that this gene has a log2 fold change of approximately 1.200 and an adjusted p-value of 0.001388. Which protein is encoded by this gene? | INO80 complex subunit D | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06594","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a specific gene, which in turn participates in the function of UCH proteinases. Experimental data fro... | |
medium_hidden_intermediate_06597 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in turn interacts with CUL3. The expression data for this gene shows a log2 fold change of approximately -1.176 and an adjusted p-value of 0.01601. Which protein is encoded by this gene? | BTB/POZ domain-containing protein KCTD2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06597","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in tu... | |
medium_hidden_intermediate_06598 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to glioma via a biomarker relationship. One of these genes is associated with a study reporting a log2 fold change of approximately 1.118 and an adjusted p-value of approximately 3.22e-05. Which gene inter... | PRKN | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06598","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to glioma... | |
medium_hidden_intermediate_06600 | In a study of Dengue virus infection in hepatoma cells (GSE110512), a specific gene is downregulated by the virus and participates in chromatin modifying enzyme activity. This gene exhibits a log2 fold change of approximately -2.96 and an adjusted p-value of 0.034. Which protein is encoded by this gene? | Histone H4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06600","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Dengue virus infection in hepatoma cells (GSE110512), a specific gene is downregulated by the virus and partic... | |
medium_hidden_intermediate_06601 | Zika virus downregulates a gene that is involved in the positive regulation of GTPase activity. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -1.707 and an adjusted p-value of 0.00474. Which protein is encoded by this gene? | Zinc finger CCCH domain-containing protein 15 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06601","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the positive regulation of GTPase activity. In a study of glioma stem ce... | |
medium_hidden_intermediate_06604 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and subsequently interacts with NPM1. Evidence for this gene reports a log2 fold change of approximately 1.76 and an adjusted p-value of 0.01444. Which protein is encoded by this gene? | DnaJ homolog subfamily B member 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06604","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and subsequent... | |
medium_hidden_intermediate_06605 | A gene is downregulated by Primate bocaparvovirus 1 and is involved in the T cell receptor signaling pathway. Experimental data for this gene reports a log2 fold change of -1.293 and an adjusted p-value of 0.04687. Which protein is encoded by this gene? | Apoptosis regulatory protein Siva | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06605","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and is involved in the T cell receptor signaling pathway. Experimental d... | |
medium_hidden_intermediate_06606 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the ERAD pathway. Evidence for this specific gene reports a log2 fold change of 1.574 and an adjusted p-value of 0.02112. Which cellular component is this gene located in? | Hrd1p ubiquitin ligase complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06606","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the ERAD pathway. Evidence for ... | |
medium_hidden_intermediate_06607 | Hepacivirus C is reported to downregulate a gene that participates in Asparagine N-linked glycosylation. Evidence for one such gene indicates a log2 fold change of -1.407 and an adjusted p-value of 0.01021. In which cell type is this specific gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06607","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that participates in Asparagine N-linked glycosylation. Evidence for one su... | |
medium_hidden_intermediate_06608 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in the metabolism of water-soluble vitamins and cofactors. One of these genes exhibits a log2 fold change of approximately -1.60 and an adjusted p-value of approximately 0.0058 in choroid plexus epithelium. Which cellul... | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06608","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in the metabolism of wa... | |
medium_hidden_intermediate_06609 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are located in the late endosome. One of these genes exhibits a log2 fold change of approximately 1.408 and an adjusted p-value of 1.419e-05 in a specific cell type. Which cell type is enriched for this specific gene? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06609","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are located in the late endosome. One... | |
medium_hidden_intermediate_06610 | Zika virus downregulates a gene that participates in SUMOylation. In glioma stem cells, one such gene exhibits a log2 fold change of -2.158 and an adjusted p-value of 0.0234. Which protein is encoded by this gene? | RWD domain-containing protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06610","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in SUMOylation. In glioma stem cells, one such gene exhibits a log2 fold c... | |
medium_hidden_intermediate_06611 | In a study of glioma stem cells (GSE114907), a gene is downregulated by Zika virus and enables mRNA binding. This specific gene exhibits a log2 fold change of approximately -1.32 and an adjusted p-value of approximately 0.03. Which protein does this gene interact with? | RBM39 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06611","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), a gene is downregulated by Zika virus and enables mRNA binding. This specific g... | |
medium_hidden_intermediate_06612 | Human immunodeficiency virus 1 upregulates a gene that binds to GNAT3. Experimental data for this gene reports a log2 fold change of 1.566 and an adjusted p-value of 0.03237. Which protein is encoded by this gene? | Growth-regulated alpha protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06612","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that binds to GNAT3. Experimental data for this gene reports a log2 fold c... | |
medium_hidden_intermediate_06613 | In a study of Human alphaherpesvirus 1 infection in a monocytic leukemia cell line (GSE114966), a specific gene product is upregulated by the virus and participates in cellular responses to stimuli. This entity exhibits a log2 fold change of 2.471 and an adjusted p-value of 0.008025. Which protein is encoded by the gen... | Histone H3.1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06613","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Human alphaherpesvirus 1 infection in a monocytic leukemia cell line (GSE114966), a specific gene product is u... | |
medium_hidden_intermediate_06616 | Human immunodeficiency virus 1 downregulates a gene that is involved in proteolysis. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of -1.247 and an adjusted p-value of 0.007125. Which protein is encoded by this specific gene? | Matrix metalloproteinase-19 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06616","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is involved in proteolysis. In a study of macrophages (GSE108897), ... | |
medium_hidden_intermediate_06617 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship and to the process 'Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3' via a 'participates in' relationship. One of these genes has a reported log2 f... | lung sarcomatoid carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06617","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an 'upregulates' relationship... | |
medium_hidden_intermediate_06618 | CUL3 interacts with multiple proteins that possess protein binding activity. One such interaction partner is identified in a study stating: 'Using yeast two-hybrid analysis and co-immunoprecipitation we show that all three RhoBTB proteins interact with Cul3.' Which protein is encoded by the gene corresponding to this s... | Rho-related BTB domain-containing protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06618","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"CUL3 interacts with multiple proteins that possess protein binding activity. One such interaction partner is identified in a... | |
medium_hidden_intermediate_06620 | Zika virus downregulates a specific gene that participates in MAPK1/MAPK3 signaling. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -2.59 and an adjusted p-value of 0.0178. Which cellular component is this gene located in? | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06620","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in MAPK1/MAPK3 signaling. In a study of glioma stem cells (GSE114... | |
medium_hidden_intermediate_06621 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes that enable protein homodimerization activity. One such gene exhibited a log2 fold change of approximately 1.62 and an adjusted p-value of 0.000626. Which protein is encoded by this specific gene? | Choline kinase alpha | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06621","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes that enable ... | |
medium_hidden_intermediate_06622 | A gene is downregulated by Cardiovirus A and enables identical protein binding. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of approximately -1.28 and an adjusted p-value of approximately 0.011. Which disease is associated with this gene? | amyloidosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06622","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Cardiovirus A and enables identical protein binding. Experimental data for this gene in a cervica... | |
medium_hidden_intermediate_06624 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to multiple sclerosis via biomarker association. One of these genes is associated with a log2 fold change of approximately 1.141 and an adjusted p-value of 0.003728. Which protein is encoded by this specific gene? | G-protein coupled receptor 65 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06624","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via upregulation and to multiple sclerosis via... | |
medium_hidden_intermediate_06625 | Two genes are upregulated by Human immunodeficiency virus 1 and are enriched in Gamma delta(γδ) T cells. One of these genes exhibits a log2 fold change of approximately 1.18 and an adjusted p-value of 0.0276 in a specific study context. Which cellular component is the location of this specific gene? | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06625","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and are enriched in Gamma delta(γδ) T cells. One of these genes ... | |
medium_hidden_intermediate_06626 | Zika virus downregulates a specific gene that participates in translation. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -1.597 and an adjusted p-value of 0.02216. Which disease is associated with this gene? | leukoencephalopathy with vanishing white matter 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06626","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in translation. In a study of glioma stem cells (GSE114907), this... | |
medium_hidden_intermediate_06628 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to Signaling by NOTCH3 via a 'participates in' relationship. One of these genes is associated with a log2 fold change of -2.433 and an adjusted p-value of 0.001717. Which cell type is that s... | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06628","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_06630 | Hepacivirus C upregulates a gene that participates in keratinization. Evidence for one such gene reports a log2 fold change of 1.563 and an adjusted p-value of 0.0424. Which protein is encoded by that gene? | Proprotein convertase subtilisin/kexin type 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06630","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in keratinization. Evidence for one such gene reports a log2 fold change ... | |
medium_hidden_intermediate_06631 | Two genes are structurally linked to ESR1 via a 'binds' interaction and to Neutrophil via an 'enriched in' interaction. One of these genes encodes a protein whose binding to estrogen receptor alpha depends in part on residues in the coactivator binding pocket distinct from those bound by TIF-2. Which protein is encoded... | Ligand-dependent corepressor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06631","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to ESR1 via a 'binds' interaction and to Neutrophil via an 'enriched in' interaction. One ... | |
medium_hidden_intermediate_06632 | Human polyomavirus 1 upregulates a gene that enables protein binding. In a study of renal epithelial cells (GSE135833), this gene exhibited a log2 fold change of 2.090 and an adjusted p-value of 0.04747. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06632","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human polyomavirus 1 upregulates a gene that enables protein binding. In a study of renal epithelial cells (GSE135833), this... | |
medium_hidden_intermediate_06634 | A gene is connected from an Epithelial cell via a 'has marker' relationship and onward to calcium ion binding via an 'enables' relationship. Evidence concerning one such entity reports that it is a member of the calcium-binding protein (CABP) family, is located in photoreceptor synaptic terminals, and is directly assoc... | non-classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06634","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is connected from an Epithelial cell via a 'has marker' relationship and onward to calcium ion binding via an 'enable... | |
medium_hidden_intermediate_06635 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the upregulation of a specific gene, which in turn interacts with the COIL protein. This gene exhibits a log2 fold change of 1.642 and an adjusted p-value of 1.968e-08. Which protein is encoded by this upregulated gene? | Protein N-terminal glutamine amidohydrolase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06635","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection leads to the upregulation of a specifi... | |
medium_hidden_intermediate_06636 | Zika virus downregulates a specific gene, which in turn interacts with HIST1H4A. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -2.217 and an adjusted p-value of 0.01641. Which disease is associated with this gene through genomic alterations? | Floating-Harbor syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06636","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with HIST1H4A. Experimental data for this gene in glioma s... | |
medium_hidden_intermediate_06638 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in Membrane Trafficking. One such gene exhibits a log2 fold change of 4.468 and an adjusted p-value of 0.02236. Which protein is encoded by this specific gene? | Ras-related protein Rab-7b | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06638","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in Membrane Traff... | |
medium_hidden_intermediate_06639 | Measles morbillivirus upregulates a gene that interacts with UBC. Experimental data for this gene shows a log2 fold change of approximately 1.001 and an adjusted p-value of 0.005921. Which protein is encoded by this gene? | Transmembrane protein 160 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06639","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that interacts with UBC. Experimental data for this gene shows a log2 fold change o... | |
medium_hidden_intermediate_06646 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Class I MHC mediated antigen processing & presentation. Experimental data for this gene reports a log2 fold change of 1.314 and an adjusted p-value of 0.02533. Which biological process is this gene involved in? | proteolysis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06646","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Class I MHC mediated anti... | |
medium_hidden_intermediate_06649 | A gene serves as a marker for microglial cells and is also identified as a biomarker for lung adenocarcinoma. Evidence regarding one such gene lists EDNRB, ADRB2, S1PR1, P2RY14, LEPR, and GHR among the findings. Which disease is connected to this specific gene through genomic alterations? | lung carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06649","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for microglial cells and is also identified as a biomarker for lung adenocarcinoma. Evidence regar... | |
medium_hidden_intermediate_06650 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and known to bind MED28 exhibits a log2 fold change of 1.392 and an adjusted p-value of 1.471e-07. Which disease is associated with this specific gene? | hypersensitivity reaction disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06650","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and known to bind MED28 ex... | |
medium_hidden_intermediate_06651 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Axon guidance. Experimental data for this gene reports a log2 fold change of approximately 2.72 and an adjusted p-value of 0.0155. Which biological process is this gene involved in? | positive regulation of transcription by RNA polymerase II | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06651","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Axon guidance. Experiment... | |
medium_hidden_intermediate_06655 | A gene is upregulated by Primate bocaparvovirus 1 and participates in the RHO GTPase cycle. Evidence for this gene reports a log2 fold change of 1.037 and an adjusted p-value of 0.0201. In which cell type is this gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06655","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and participates in the RHO GTPase cycle. Evidence for this gene reports a... | |
medium_hidden_intermediate_06656 | Zika virus downregulates a gene that interacts with CANX. In glioma stem cells (study GSE114907), one such gene exhibits a log2 fold change of approximately -1.48 and an adjusted p-value of 0.0156. Which protein is encoded by this gene? | ER membrane protein complex subunit 8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06656","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with CANX. In glioma stem cells (study GSE114907), one such gene exhibits a l... | |
medium_hidden_intermediate_06657 | Zika virus downregulates a specific gene that participates in the regulation of pyruvate metabolism. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -2.29 and an adjusted p-value of approximately 0.009. Which biological process is this gene involved in? | proteasome-mediated ubiquitin-dependent protein catabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06657","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in the regulation of pyruvate metabolism. Experimental data for t... | |
medium_hidden_intermediate_06660 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that enables palmitoyltransferase activity. One such gene exhibited a log2 fold change of approximately 1.136 and an adjusted p-value of 0.001495. Which protein is encoded by this specific gene? | Palmitoyltransferase ZDHHC3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06660","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that en... | |
medium_hidden_intermediate_06661 | A gene is upregulated by Primate bocaparvovirus 1 and participates in Signal Transduction. Experimental data for this gene in a non-Hodgkin lymphoma cell line (study GSE119608) reports a log2 fold change of 1.671 and an adjusted p-value of 0.02869. Which disease is associated with this gene through genomic alterations? | allergic asthma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06661","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and participates in Signal Transduction. Experimental data for this gene i... | |
medium_hidden_intermediate_06663 | Pegivirus C is reported to downregulate a gene that is located in the perinuclear region of the cytoplasm. Evidence for one such gene indicates a log2 fold change of -2.261 and an adjusted p-value of 0.001836. Which disease is associated with genomic alterations in this specific gene? | angioosteohypertrophic syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06663","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is located in the perinuclear region of the cytoplasm. Evidence for one ... | |
medium_hidden_intermediate_06664 | In a study involving Human gammaherpesvirus 8, two genes are known to be upregulated by the virus and to interact with the protein BACH1. One of these genes exhibits a log2 fold change of approximately 1.01 and an adjusted p-value of 1.28e-05 in umbilical vein endothelial cells. Which protein is encoded by this specifi... | Homeobox protein Hox-B8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06664","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study involving Human gammaherpesvirus 8, two genes are known to be upregulated by the virus and to interact with the p... | |
medium_hidden_intermediate_06668 | Two genes are downregulated by Pegivirus C and enriched in naive CD4+ T cells. One of these genes exhibits a log2 fold change of approximately -1.575 and an adjusted p-value of 0.003028 in peripheral blood mononuclear cells. Which cellular component is the location of this specific gene? | endoplasmic reticulum | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06668","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and enriched in naive CD4+ T cells. One of these genes exhibits a log2 fold chang... | |
medium_hidden_intermediate_06669 | Pegivirus C is reported to downregulate a gene that subsequently interacts with GLI1. In a study of peripheral blood mononuclear cells (GSE131504), one such intermediate gene exhibits a log2 fold change of -1.205 and an adjusted p-value of 0.001653. Which protein is encoded by this specific gene? | Protein fem-1 homolog B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06669","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that subsequently interacts with GLI1. In a study of peripheral blood mononuc... | |
medium_hidden_intermediate_06670 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene that participates in Creatine metabolism. One such gene exhibited a log2 fold change of 1.138 and an adjusted p-value of 0.003398. Which protein is encoded by this specific gene? | Creatine kinase U-type, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06670","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to upre... | |
medium_hidden_intermediate_06672 | Two genes are linked to Vaccinia virus via an upregulation relationship and to pancreatic neoplasm via a biomarker relationship. One of these genes is associated with a log2 fold change of approximately 2.16 and an adjusted p-value of approximately 2.86e-05 in a study of cervical adenocarcinoma cell lines. Which protei... | Placenta-specific gene 8 protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06672","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Vaccinia virus via an upregulation relationship and to pancreatic neoplasm via a biomarker relations... | |
medium_hidden_intermediate_06674 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a gene that enables ATP-dependent activity acting on DNA. This specific gene exhibited a log2 fold change of approximately 3.29 and an adjusted p-value of approximately 2.62e-11. Which protein is encoded by this gen... | DNA repair and recombination protein RAD54B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06674","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a gene that enables... | |
medium_hidden_intermediate_06675 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection was found to upregulate certain genes that subsequently interact with HIF1AN. One such gene exhibited a log2 fold change of 2.546 and an adjusted p-value of 3.798e-08. Which protein is encoded by this specific gene? | Ankyrin repeat domain-containing protein 12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06675","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection was found to upregulate... | |
medium_hidden_intermediate_06678 | Human alphaherpesvirus 3 is reported to upregulate a gene that is enriched in Regulatory T (Treg) cells. Evidence for this specific gene in a melanoma cell line (study GSE136586) shows a log2 fold change of 1.619 and an adjusted p-value of 3.464e-07. Which protein is encoded by this gene? | Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06678","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 is reported to upregulate a gene that is enriched in Regulatory T (Treg) cells. Evidence for this s... |
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