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medium_hidden_intermediate_06242 | In a study of macrophages (GSE108897), a gene is identified as being downregulated by Human immunodeficiency virus 1 and serving as a biomarker for hepatocellular carcinoma. This specific gene exhibits a log2 fold change of approximately -2.38 and an adjusted p-value of approximately 0.0176. Which protein is encoded by... | Natural cytotoxicity triggering receptor 3 ligand 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06242","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified as being downregulated by Human immunodeficiency virus 1 and ser... | |
medium_hidden_intermediate_06244 | In a study of cervical adenocarcinoma cells (GSE11238), a gene upregulated by Vaccinia virus and involved in protein import into the nucleus was found to have a log2 fold change of 2.011 and an adjusted p-value of 0.0003393. Which gene binds to this specific entity? | HSPA1B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06244","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), a gene upregulated by Vaccinia virus and involved in protein import ... | |
medium_hidden_intermediate_06245 | Vaccinia virus infection has been shown to upregulate certain genes that are subsequently associated with pancreatic ductal adenocarcinoma. One such gene exhibits a log2 fold change of 2.753 and an adjusted p-value of 3.474e-07 in cervical adenocarcinoma cell lines. Which protein is encoded by this specific gene? | Kallikrein-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06245","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus infection has been shown to upregulate certain genes that are subsequently associated with pancreatic ductal ... | |
medium_hidden_intermediate_06250 | Enterovirus A upregulates a gene that is involved in sodium ion transmembrane transport. Evidence for this gene reports a log2 fold change of 2.528 and an adjusted p-value of 0.01729. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06250","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates a gene that is involved in sodium ion transmembrane transport. Evidence for this gene reports a lo... | |
medium_hidden_intermediate_06251 | Hepacivirus C upregulates a gene that interacts with SNRNP70. Experimental data for this gene in hepatocytes (study GSE132606) shows a log2 fold change of 1.648 and an adjusted p-value of 6.371e-05. Which protein is encoded by this gene? | Target of EGR1 protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06251","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that interacts with SNRNP70. Experimental data for this gene in hepatocytes (study GSE13260... | |
medium_hidden_intermediate_06252 | Rhinovirus A is known to downregulate certain genes that are located in the extracellular region. One such gene exhibits a log2 fold change of -1.453 and an adjusted p-value of 0.003538 in cytotoxic T-lymphocytes (from study GSE106475). Which disease is associated with this specific gene as a biomarker? | malignant colon neoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06252","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A is known to downregulate certain genes that are located in the extracellular region. One such gene exhibits a l... | |
medium_hidden_intermediate_06254 | Human immunodeficiency virus 1 upregulates a gene that participates in SLC-mediated transmembrane transport. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of 1.211 and an adjusted p-value of 0.001489. Which disease is associated with this gene as a biomarker? | schizophrenia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06254","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in SLC-mediated transmembrane transport. Evidence for th... | |
medium_hidden_intermediate_06255 | Zika virus downregulates a gene that is associated with severe combined immunodeficiency. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -1.172 and an adjusted p-value of 0.02441. Which protein is encoded by this gene? | Beta-glucuronidase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06255","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is associated with severe combined immunodeficiency. In a study of glioma stem cells (G... | |
medium_hidden_intermediate_06256 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the negative regulation of cell population proliferation. Evidence for this gene reports a log2 fold change of -1.103 and an adjusted p-value of 0.002886. Which cell type is this gene enriched in? | conventional dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06256","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the negative regulation ... | |
medium_hidden_intermediate_06258 | Two genes are each upregulated by Hepacivirus C and serve as biomarkers for melanoma. One of these genes was reported in a study (GSE119117) involving peripheral blood mononuclear cells, with a log2 fold change of approximately 2.16 and an adjusted p-value of approximately 0.029. Which protein interacts with this speci... | SMARCA4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06258","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are each upregulated by Hepacivirus C and serve as biomarkers for melanoma. One of these genes was reported in a s... | |
medium_hidden_intermediate_06260 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in G alpha (i) signalling events. One of these genes exhibits a log2 fold change of -1.311 and an adjusted p-value of 1.276e-07 in a specific study. Which cell type is enriched for this specific gene? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06260","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and participate in G alpha (i) signalli... | |
medium_hidden_intermediate_06262 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in the RHOC GTPase cycle. One such gene exhibits a log2 fold change of 1.507 and an adjusted p-value of 0.0003728. Which protein is encoded by this specific gene? | Serine/threonine-protein kinase N3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06262","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that participates in the RHOC GTPas... | |
medium_hidden_intermediate_06263 | Enterovirus A upregulates multiple genes that enable DNA-binding transcription activator activity, RNA polymerase II-specific. One such gene exhibits a log2 fold change of approximately 1.16 and an adjusted p-value of 0.0157 in rhabdomyosarcoma cells. Which protein does this specific gene product interact with? | RFXANK | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06263","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates multiple genes that enable DNA-binding transcription activator activity, RNA polymerase II-specifi... | |
medium_hidden_intermediate_06265 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is located in the glutamatergic synapse. Experimental data for this gene reports a log2 fold change of approximately 1.96 and an adjusted p-value of approximately 0.028. Which disease is associated with this gene? | anxiety | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06265","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is located in the glutamatergic synapse. ... | |
medium_hidden_intermediate_06266 | Human alphaherpesvirus 3 is known to downregulate a gene that is located in the lysosomal membrane. In a study of melanoma cell lines (GSE136586), one such gene exhibited a log2 fold change of -1.130 and an adjusted p-value of 0.000465. Which protein does this specific gene interact with? | LGALS3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06266","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 is known to downregulate a gene that is located in the lysosomal membrane. In a study of melanoma c... | |
medium_hidden_intermediate_06267 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in the formation of the cornified envelope. Experimental data for this gene reports a log2 fold change of -3.751 and an adjusted p-value of 0.04183. Which protein is encoded by this gene? | Serine protease inhibitor Kazal-type 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06267","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in the formation of the co... | |
medium_hidden_intermediate_06269 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables DNA-binding transcription repressor activity, RNA polymerase II-specific. Experimental data for this gene reports a log2 fold change of -2.463 and an adjusted p-value of 0.03461. Which protein is encoded by this gene? | Nuclear factor of activated T-cells, cytoplasmic 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06269","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables DNA-binding transcription repre... | |
medium_hidden_intermediate_06270 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and known to interact with MYC was found to have a log2 fold change of 6.770 and an adjusted p-value of 2.524e-09. Which disease is associated with this specific gene? | telangiectasis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06270","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene upregulated by Vaccinia virus and known to interact with... | |
medium_hidden_intermediate_06271 | Zika virus upregulates a specific gene that is involved in the negative regulation of transcription by RNA polymerase II. Experimental data from neural stem cells (study GSE129180) indicates this gene has a log2 fold change of approximately 1.009 and an adjusted p-value of 0.00398. Which disease is associated with this... | breast carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06271","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a specific gene that is involved in the negative regulation of transcription by RNA polymerase II. Ex... | |
medium_hidden_intermediate_06275 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in turn interacts with NUMA1. This gene exhibited a log2 fold change of approximately -1.55 and an adjusted p-value of 0.0057. Which protein is encoded by this gene? | Protein ECT2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06275","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in tu... | |
medium_hidden_intermediate_06276 | Zika virus downregulates a gene that enables protein serine/threonine kinase activity. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -3.082 and an adjusted p-value of 0.01501. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06276","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that enables protein serine/threonine kinase activity. In a study of glioma stem cells (GSE1... | |
medium_hidden_intermediate_06277 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via a downregulation relationship and to colon carcinoma via a biomarker relationship. One of these genes is associated with a study reporting a log2 fold change of -1.650 and an adjusted p-value of 0.04464. Which protein is encoded by the ge... | Free fatty acid receptor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06277","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via a downregulation relationship and to colon... | |
medium_hidden_intermediate_06278 | A gene is upregulated by Primate bocaparvovirus 1 and is located in the membrane. Experimental data for this gene in vascular endothelial cells (study GSE16354) reports a log2 fold change of 1.143 and an adjusted p-value of 0.04941. Which biological process is this gene involved in? | G protein-coupled receptor signaling pathway | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06278","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Primate bocaparvovirus 1 and is located in the membrane. Experimental data for this gene in vascula... | |
medium_hidden_intermediate_06279 | Hepacivirus C downregulates a gene that participates in the mitotic cell cycle. Evidence for this gene in peripheral blood mononuclear cells (study GSE119117) reports a log2 fold change of -1.770 and an adjusted p-value of 0.01453. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06279","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C downregulates a gene that participates in the mitotic cell cycle. Evidence for this gene in peripheral blood m... | |
medium_hidden_intermediate_06283 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes that participate in mitochondrial biogenesis. One such gene exhibited a log2 fold change of 1.697 and an adjusted p-value of 1.067e-08. Which protein is encoded by this specific gene? | MICOS complex subunit MIC10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06283","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes ... | |
medium_hidden_intermediate_06284 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the antibacterial humoral response. Experimental data for this gene reports a log2 fold change of -1.639 and an adjusted p-value of 0.02145. Which protein is encoded by this gene? | Ribonuclease 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06284","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the antibacterial humora... | |
medium_hidden_intermediate_06285 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in transport across the blood-brain barrier. Evidence for one such gene reports a log2 fold change of 2.253 and an adjusted p-value of 0.03712. Which protein is encoded by that gene? | Sodium-coupled neutral amino acid transporter 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06285","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in transport across the blood-brai... | |
medium_hidden_intermediate_06286 | COMMD1 interacts with a specific protein that enables protein binding. Experimental evidence using specific antisera describes the interaction between endogenous COMMD1 and this protein. Which cell type is this protein enriched in? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06286","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"COMMD1 interacts with a specific protein that enables protein binding. Experimental evidence using specific antisera describ... | |
medium_hidden_intermediate_06288 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection was found to downregulate a gene that participates in the metabolism of vitamins and cofactors. One such gene exhibited a log2 fold change of -1.114 and an adjusted p-value of 0.0008106. Which protein is encoded by this specific gene? | Retinol-binding protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06288","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection was found to downregulate a gene that ... | |
medium_hidden_intermediate_06290 | In a study of Human alphaherpesvirus 1 infection in a monocytic leukemia cell line, two genes are known to be upregulated by the virus and to interact with KEAP1. One of these genes exhibits a log2 fold change of approximately 1.44 and an adjusted p-value of approximately 0.0043. What molecular function is enabled by t... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06290","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Human alphaherpesvirus 1 infection in a monocytic leukemia cell line, two genes are known to be upregulated by... | |
medium_hidden_intermediate_06291 | Human immunodeficiency virus 1 upregulates a gene that is associated with neuroblastoma. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately 3.09 and an adjusted p-value of approximately 0.000318. Which protein is encoded by this gene? | Fatty acid-binding protein, heart | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06291","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is associated with neuroblastoma. In a study of macrophages (GSE10889... | |
medium_hidden_intermediate_06292 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection was found to downregulate a gene that enables DNA-binding transcription factor activity. One such gene exhibited a log2 fold change of approximately -1.066 and an adjusted p-value of 7.895e-05. Which protein is encoded by this specifi... | Zinc finger protein 285 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06292","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus infection was found to downregulate a gene that ... | |
medium_hidden_intermediate_06294 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in Lewis blood group biosynthesis. Evidence for one such gene reports a log2 fold change of -1.456 and an adjusted p-value of 7.316e-05. Which protein is encoded by that gene? | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06294","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in Lewis blood group biosynthes... | |
medium_hidden_intermediate_06295 | Two genes are upregulated by Measles morbillivirus and participate in the regulation of endogenous retroelements. One of these genes exhibits a log2 fold change of approximately 1.008 and an adjusted p-value of 0.00172 in pleural mesothelioma cells. Which disease is associated with this specific gene? | gastric cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06295","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Measles morbillivirus and participate in the regulation of endogenous retroelements. One of the... | |
medium_hidden_intermediate_06296 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a downregulation relationship and to SLC30A1 via an interaction relationship. One of these genes is associated with experimental data showing a log2 fold change of -1.479 and an adjusted p-value of 0.007736. Which protein is ... | Transmembrane channel-like protein 8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06296","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a downregulation relationship... | |
medium_hidden_intermediate_06297 | PLK1 interacts with a protein that is located in the nucleus. Evidence indicates that endogenous human PLK protein, immunoprecipitated from G2/M-arrested Jurkat cells, directly phosphorylates this specific protein. Which protein is encoded by the gene corresponding to this phosphorylated entity? | M-phase inducer phosphatase 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06297","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"PLK1 interacts with a protein that is located in the nucleus. Evidence indicates that endogenous human PLK protein, immunopr... | |
medium_hidden_intermediate_06300 | Two genes are upregulated by Human immunodeficiency virus 1 and associated with breast carcinoma. One of these genes exhibits a log2 fold change of 1.875 and an adjusted p-value of 4.339e-05 in macrophages. Which cellular component is the location of this specific gene? | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06300","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and associated with breast carcinoma. One of these genes exhibit... | |
medium_hidden_intermediate_06301 | In a study of bronchial epithelial cells (GSE150819), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene involved in carbohydrate metabolic process. This specific gene exhibited a log2 fold change of approximately 4.40 and an adjusted p-value of approximately 0.0028. Which protein does... | MAPK1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06301","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of bronchial epithelial cells (GSE150819), Severe acute respiratory syndrome-related coronavirus was found to upr... | |
medium_hidden_intermediate_06302 | A protein interacts with IRAK1 and is localized in the cytoplasm. Experimental evidence indicates that this protein forms a complex with IRAK prior to IL-1beta treatment, and its recruitment to the activated receptor complex is mediated by its association with IL-1RAcP. Which protein is encoded by the gene correspondin... | Toll-interacting protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06302","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A protein interacts with IRAK1 and is localized in the cytoplasm. Experimental evidence indicates that this protein forms a ... | |
medium_hidden_intermediate_06303 | Human immunodeficiency virus 1 upregulates a gene that participates in Inositol phosphate metabolism. Evidence for this specific gene reports a log2 fold change of approximately 1.57 and an adjusted p-value of approximately 0.022. Which biological process is this gene involved in? | small GTPase-mediated signal transduction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06303","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in Inositol phosphate metabolism. Evidence for this spec... | |
medium_hidden_intermediate_06304 | A gene is downregulated by Primate bocaparvovirus 1 and enables receptor ligand activity. Experimental evidence for this gene reports a log2 fold change of -1.033 and an adjusted p-value of 0.009306. Which disease is associated with this gene through genomic alterations? | gastric cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06304","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and enables receptor ligand activity. Experimental evidence for this gen... | |
medium_hidden_intermediate_06305 | Human immunodeficiency virus 1 upregulates a gene that is located in the ciliary basal body. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of 1.351 and an adjusted p-value of 0.02396. Which biological process is this gene involved in? | spermatid development | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06305","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is located in the ciliary basal body. Evidence for this gene in macro... | |
medium_hidden_intermediate_06306 | Human betaherpesvirus 5 upregulates a gene that is associated with leukemia. Evidence for this specific gene reports a log2 fold change of 1.878 and an adjusted p-value of 0.008826. Which disease is causally linked to this gene? | congestive heart failure | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06306","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that is associated with leukemia. Evidence for this specific gene reports a log2 ... | |
medium_hidden_intermediate_06307 | Zika virus downregulates a gene that enables 2-oxoglutarate-dependent dioxygenase activity. In glioma stem cells, one such gene exhibits a log2 fold change of -3.527 and an adjusted p-value of 0.005289. Which protein is encoded by this gene? | Ribosomal oxygenase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06307","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that enables 2-oxoglutarate-dependent dioxygenase activity. In glioma stem cells, one such g... | |
medium_hidden_intermediate_06308 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that enables small GTPase binding. This specific gene exhibited a log2 fold change of approximately 1.106 and an adjusted p-value of 0.01043. Which cellular component is this gene located in? | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06308","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that en... | |
medium_hidden_intermediate_06309 | A gene is downregulated by Human gammaherpesvirus 8 and participates in Peptide ligand-binding receptors. Experimental data for this gene in vascular endothelial cells (study GSE16354) reports a log2 fold change of -2.323 and an adjusted p-value of 0.0008856. Which cellular component is this gene located in? | plasma membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06309","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Human gammaherpesvirus 8 and participates in Peptide ligand-binding receptors. Experimental data ... | |
medium_hidden_intermediate_06310 | In a study of Human alphaherpesvirus 1 infection in a monocytic leukemia cell line, a specific gene is upregulated by the virus and its product binds to SEC13. This gene exhibits a log2 fold change of approximately 1.39 and an adjusted p-value of approximately 0.0035. Which protein is encoded by this gene? | Nuclear pore complex protein Nup155 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06310","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Human alphaherpesvirus 1 infection in a monocytic leukemia cell line, a specific gene is upregulated by the vi... | |
medium_hidden_intermediate_06311 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in the negative regulation of the MAPK pathway. Evidence for one such gene reports a log2 fold change of -2.345 and an adjusted p-value of 0.001066. Which protein is encoded by that gene? | Dual specificity protein phosphatase 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06311","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in the negative regulation of t... | |
medium_hidden_intermediate_06312 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the positive regulation of angiogenesis. Evidence for one such gene reports a log2 fold change of 1.279 and an adjusted p-value of 0.02652. Which protein is encoded by that gene? | Fibroblast growth factor 18 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06312","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the positive regulation of angi... | |
medium_hidden_intermediate_06314 | Human immunodeficiency virus 1 upregulates a gene that enables protein serine/threonine kinase activity. Evidence for this gene reports a log2 fold change of 1.838 and an adjusted p-value of 0.006371. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06314","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that enables protein serine/threonine kinase activity. Evidence for this g... | |
medium_hidden_intermediate_06316 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in anatomical structure morphogenesis. Experimental data for this gene reports a log2 fold change of 1.702 and an adjusted p-value of 0.03852. Which protein is encoded by this gene? | Protein phosphatase EYA3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06316","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in anatomical structure morph... | |
medium_hidden_intermediate_06317 | Enterovirus A upregulates a specific gene that is involved in signal transduction. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) reports a log2 fold change of approximately 1.019 and an adjusted p-value of approximately 0.0139. Which disease is associated with this gene? | VISS syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06317","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A upregulates a specific gene that is involved in signal transduction. Experimental data for this gene in rhabdo... | |
medium_hidden_intermediate_06318 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with HIST1H3A. One such gene exhibits a log2 fold change of 1.570 and an adjusted p-value of 2.775e-06. In which cell type is this specific gene enriched? | classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06318","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that interacts with HIST1H3A. One such gene exhibit... | |
medium_hidden_intermediate_06319 | Two genes are structurally linked from Vaccinia virus via a downregulation relationship and onward to adenoviridae infectious disease via an association relationship. One of these genes is reported in study GSE11238 (VExD) with a log2 fold change of -2.104 and an adjusted p-value of 0.004015. Which cell type is that sp... | conventional dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06319","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Vaccinia virus via a downregulation relationship and onward to adenoviridae infectiou... | |
medium_hidden_intermediate_06321 | In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to downregulate a gene that participates in the biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and its transfer to a nascent protein. This specific gene exhibited a l... | Golgi apparatus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06321","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), Severe acute respiratory syndrome-related coronavirus was found to down... | |
medium_hidden_intermediate_06322 | Zika virus downregulates a specific gene, which in turn interacts with UBC. Experimental data from glioma stem cells (study GSE114907) indicates that this gene has a log2 fold change of -3.448 and an adjusted p-value of 0.003194. Which protein does this gene bind to? | SELE | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06322","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with UBC. Experimental data from glioma stem cells (study ... | |
medium_hidden_intermediate_06323 | Zika virus downregulates a gene that is involved in interstrand cross-link repair. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of approximately -3.43 and an adjusted p-value of 0.0099. Which cellular component is this specific gene located in? | site of DNA damage | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06323","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in interstrand cross-link repair. In a study of glioma stem cells (GSE11490... | |
medium_hidden_intermediate_06324 | Enterovirus A is reported to upregulate a gene that is located in the nucleolus. Experimental data for one such gene indicates a log2 fold change of approximately 1.06 and an adjusted p-value of 0.0093. Which disease is associated with this gene as a biomarker? | pediatric osteosarcoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06324","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to upregulate a gene that is located in the nucleolus. Experimental data for one such gene indicat... | |
medium_hidden_intermediate_06325 | Zika virus downregulates multiple genes involved in spliceosomal snRNP assembly. One such gene exhibits a log2 fold change of -3.238 and an adjusted p-value of 0.002957 in glioma stem cells. Which protein is encoded by this specific gene? | Gem-associated protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06325","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates multiple genes involved in spliceosomal snRNP assembly. One such gene exhibits a log2 fold change o... | |
medium_hidden_intermediate_06326 | Pegivirus C is reported to downregulate a gene that is involved in protein K48-linked ubiquitination. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.070 and an adjusted p-value of 0.002096. Which protein is encoded by this specific gene? | Ubiquitin-conjugating enzyme E2 Q2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06326","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in protein K48-linked ubiquitination. In a study of peripher... | |
medium_hidden_intermediate_06327 | Hepacivirus C is reported to upregulate a gene that subsequently interacts with STAU1. Experimental data for one such intermediate gene shows a log2 fold change of approximately 1.10 and an adjusted p-value of 0.02785. Which protein is encoded by this specific gene? | Zinc finger CCCH domain-containing protein 15 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06327","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a gene that subsequently interacts with STAU1. Experimental data for one such interm... | |
medium_hidden_intermediate_06328 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in CS-GAG biosynthesis. Experimental data for this gene shows a log2 fold change of -1.201 and an adjusted p-value of 0.009372. Which biological process is this gene involved in? | chondroitin sulfate proteoglycan biosynthetic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06328","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in CS-GAG biosynthesis. Ex... | |
medium_hidden_intermediate_06329 | Two genes are upregulated by Human alphaherpesvirus 1 and are involved in the positive regulation of the ERK1 and ERK2 cascade. One of these genes exhibits a log2 fold change of 1.017 and an adjusted p-value of 0.01038 in a monocytic leukemia cell line study. Which disease is associated with this specific gene as a bio... | systemic lupus erythematosus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06329","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human alphaherpesvirus 1 and are involved in the positive regulation of the ERK1 and ERK2 casca... | |
medium_hidden_intermediate_06330 | Two genes are downregulated by Pegivirus C and interact with CUL3. One of these genes exhibits a log2 fold change of approximately -1.33 and an adjusted p-value of 0.00584 in peripheral blood mononuclear cells from study GSE131504. Which biological process is this specific gene involved in? | cytoplasmic microtubule organization | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06330","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and interact with CUL3. One of these genes exhibits a log2 fold change of approxi... | |
medium_hidden_intermediate_06331 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus was found to upregulate a gene that participates in the RHO GTPase cycle. This specific gene exhibited a log2 fold change of approximately 1.108 and an adjusted p-value of 0.00322. Which protein is encoded by this gene? | Rho GTPase-activating protein 19 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06331","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus was found to upregulate a gene that participates... | |
medium_hidden_intermediate_06335 | Human betaherpesvirus 5 upregulates a gene that participates in Signaling by Interleukins. Evidence for this gene in foreskin fibroblast cell lines (study GSE130665) reports a log2 fold change of approximately 1.39 and an adjusted p-value of 0.0012. Which disease is associated with this gene through genomic alterations... | thyroid cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06335","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in Signaling by Interleukins. Evidence for this gene in foreski... | |
medium_hidden_intermediate_06336 | In a study of glioma stem cells (GSE114907), Zika virus infection leads to the downregulation of a specific gene, which in turn interacts with RAC1. This gene exhibits a log2 fold change of approximately -1.23 and an adjusted p-value of 0.018. Which protein is encoded by this gene? | Casein kinase I isoform gamma-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06336","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus infection leads to the downregulation of a specific gene, which in t... | |
medium_hidden_intermediate_06338 | Hepacivirus C upregulates a gene that subsequently binds to YWHAZ. Experimental data for one such intermediate gene reports a log2 fold change of 1.577 and an adjusted p-value of 0.01428. Which protein is encoded by this specific gene? | Platelet glycoprotein IX | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06338","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that subsequently binds to YWHAZ. Experimental data for one such intermediate gene reports ... | |
medium_hidden_intermediate_06339 | Influenza A virus downregulates a gene that enables phospholipid scramblase activity. Experimental data for this gene shows a log2 fold change of -1.369 and an adjusted p-value of 0.01779. Which protein is encoded by this gene? | Serine incorporator 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06339","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Influenza A virus downregulates a gene that enables phospholipid scramblase activity. Experimental data for this gene shows ... | |
medium_hidden_intermediate_06341 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated by the virus and its product binds to KAT2B. Evidence for this gene reports a log2 fold change of 1.124 and an adjusted p-value of 0.00602. Which protein is encoded by this gene? | Cysteine-rich protein 2-binding protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06341","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated by the virus a... | |
medium_hidden_intermediate_06342 | Human immunodeficiency virus 1 upregulates a gene that is enriched in Mucosa-associated invariant T (MAIT) cells. Evidence for this gene in macrophages reports a log2 fold change of 5.968 and an adjusted p-value of 6.537e-05. Which protein is encoded by this gene? | LON peptidase N-terminal domain and RING finger protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06342","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is enriched in Mucosa-associated invariant T (MAIT) cells. Evidence f... | |
medium_hidden_intermediate_06343 | Zika virus downregulates a gene that interacts with SRPK2. In glioma stem cells (study GSE114907), one such downregulated gene exhibits a log2 fold change of approximately -1.10 and an adjusted p-value of 0.0065. Which protein is encoded by this specific gene? | Zinc finger protein 638 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06343","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with SRPK2. In glioma stem cells (study GSE114907), one such downregulated ge... | |
medium_hidden_intermediate_06346 | In a study of lung cells (GSE148697), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene that is involved in the positive regulation of the fibroblast apoptotic process. One such gene exhibited a log2 fold change of approximately 1.276 and an adjusted p-value of 0.01504. Which protein ... | Serine/threonine-protein kinase 17A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06346","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells (GSE148697), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene t... | |
medium_hidden_intermediate_06348 | Vaccinia virus downregulates a gene that is a component of the MSL complex. In a study of cervical adenocarcinoma cell lines (GSE11238), one such gene exhibited a log2 fold change of -1.728 and an adjusted p-value of 0.01491. Which protein is encoded by this specific gene? | E3 ubiquitin-protein ligase MSL2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06348","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus downregulates a gene that is a component of the MSL complex. In a study of cervical adenocarcinoma cell lines... | |
medium_hidden_intermediate_06350 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes that participate in Azathioprine ADME. One such gene exhibited a log2 fold change of approximately 5.18 and an adjusted p-value of approximately 1.83e-06. Which protein is encoded by this specific... | Equilibrative nucleoside transporter 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06350","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate certain genes ... | |
medium_hidden_intermediate_06351 | Zika virus downregulates a gene that is involved in the defense response to virus. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -2.829 and an adjusted p-value of 0.005824. Which protein is encoded by this specific gene? | Nuclear cap-binding protein subunit 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06351","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the defense response to virus. In a study of glioma stem cells (GSE11490... | |
medium_hidden_intermediate_06353 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and both interact with VIM. One of these genes exhibits a log2 fold change of approximately -2.12 and an adjusted p-value of 0.0072 in sclera cells (study GSE164073). Which disease is associated with genomic alterations in this specifi... | diabetes mellitus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06353","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and both interact with VIM. One of thes... | |
medium_hidden_intermediate_06354 | Two genes are upregulated by Vaccinia virus and interact with KBTBD4. One of these genes exhibits a log2 fold change of approximately 1.36 and an adjusted p-value of approximately 3.34e-06 in cervical adenocarcinoma cells. Which cellular component is the gene matching these statistics located in? | extracellular space | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06354","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and interact with KBTBD4. One of these genes exhibits a log2 fold change of appr... | |
medium_hidden_intermediate_06356 | In the context of Severe acute respiratory syndrome-related coronavirus infection, two genes are known to be upregulated by the virus and subsequently participate in the Toll Like Receptor TLR6:TLR2 Cascade. One of these genes exhibits a log2 fold change of 3.939 and an adjusted p-value of 0.02879 in a specific study. ... | Ubl carboxyl-terminal hydrolase 18 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06356","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In the context of Severe acute respiratory syndrome-related coronavirus infection, two genes are known to be upregulated by ... | |
medium_hidden_intermediate_06357 | Vaccinia virus downregulates a gene that interacts with RAP1GDS1. In a study of cervical adenocarcinoma cell lines (GSE11238), one such gene exhibits a log2 fold change of -1.785 and an adjusted p-value of 2.354e-06. Which protein is encoded by this gene? | GTP-binding protein Di-Ras1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06357","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus downregulates a gene that interacts with RAP1GDS1. In a study of cervical adenocarcinoma cell lines (GSE11238... | |
medium_hidden_intermediate_06358 | Pegivirus C is reported to downregulate a gene that enables DNA-binding transcription factor activity. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.056 and an adjusted p-value of 0.003122. Which protein is encoded by this specific gene? | Zinc finger protein 263 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06358","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that enables DNA-binding transcription factor activity. In a study of periphe... | |
medium_hidden_intermediate_06359 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate certain host genes that enable phosphatidylinositol-3,4-bisphosphate binding. One such gene exhibited a log2 fold change of -1.223 and an adjusted p-value of 0.00841. Which protein is encoded by this specific... | F-BAR and double SH3 domains protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06359","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate certain host... | |
medium_hidden_intermediate_06360 | Human betaherpesvirus 5 upregulates a gene that subsequently binds to NCOA3. Experimental data for one such gene reports a log2 fold change of 1.043 and an adjusted p-value of 0.02647. Which protein is encoded by this gene? | Interferon regulatory factor 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06360","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that subsequently binds to NCOA3. Experimental data for one such gene reports a l... | |
medium_hidden_intermediate_06361 | Zika virus downregulates a gene that enables DNA-binding transcription activator activity, RNA polymerase II-specific. In a study of glioma stem cells (GSE114907), one such gene exhibits a log2 fold change of -2.472 and an adjusted p-value of 0.01078. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06361","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that enables DNA-binding transcription activator activity, RNA polymerase II-specific. In a ... | |
medium_hidden_intermediate_06362 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific gene involved in the negative regulation of DNA-templated transcription. This gene exhibited a log2 fold change of approximately -1.30 and an adjusted p-value of 0.022. Which protein is encoded by ... | Bcl-2-associated transcription factor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06362","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate a specific g... | |
medium_hidden_intermediate_06363 | Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to 'transcription cis-regulatory region binding' via an 'enables' relationship. One of these genes has an associated expression profile showing a log2 fold change of -2.207 and an adjusted p-value of 0.03532. Whic... | naive B cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06363","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to 'transcription... | |
medium_hidden_intermediate_06364 | A gene is upregulated by Vaccinia virus and enables protein homodimerization activity. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of approximately 1.95 and an adjusted p-value of approximately 1.05e-10. Which disease is associated with genomic alte... | gastric carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06364","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Vaccinia virus and enables protein homodimerization activity. Experimental data for this gene in a ... | |
medium_hidden_intermediate_06365 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables calcium-dependent phospholipid binding. Evidence for this gene reports a log2 fold change of approximately 3.09 and an adjusted p-value of 0.03112. Which protein is encoded by this gene? | Multiple C2 and transmembrane domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06365","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables calcium-dependent phospholipid binding... | |
medium_hidden_intermediate_06366 | Zika virus downregulates a specific gene that is involved in rRNA processing. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -1.124 and an adjusted p-value of 0.04628. Which cellular component is this gene located in? | nucleolus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06366","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is involved in rRNA processing. In a study of glioma stem cells (GSE114907), t... | |
medium_hidden_intermediate_06368 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and interacts with PXN. This gene exhibits a log2 fold change of 1.874 and an adjusted p-value of 7.362e-10. Which protein is encoded by this gene? | E3 ubiquitin-protein ligase SH3RF1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06368","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and interacts with PXN.... | |
medium_hidden_intermediate_06369 | Pegivirus C is reported to downregulate a specific gene, which in turn interacts with PRKAB2. Transcriptomic data from peripheral blood mononuclear cells (study GSE131504) indicates that this intermediate gene has a log2 fold change of -1.225 and an adjusted p-value of 0.00376. Which protein is encoded by this gene? | Golgi to ER traffic protein 4 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06369","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn interacts with PRKAB2. Transcriptomic data from perip... | |
medium_hidden_intermediate_06370 | Zika virus downregulates a specific gene that participates in Neddylation. Experimental data from glioma stem cells (study GSE114907) indicates this gene has a log2 fold change of -2.127 and an adjusted p-value of 0.003539. Which biological process is this gene involved in? | regulation of apoptotic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06370","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in Neddylation. Experimental data from glioma stem cells (study G... | |
medium_hidden_intermediate_06371 | Hepacivirus C upregulates a gene that is enriched in conventional dendritic cells. Evidence for one such gene reports a log2 fold change of 1.697 and an adjusted p-value of 0.01348. Which protein is encoded by that gene? | Disintegrin and metalloproteinase domain-containing protein 15 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06371","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is enriched in conventional dendritic cells. Evidence for one such gene reports a log2... | |
medium_hidden_intermediate_06374 | Human immunodeficiency virus 1 upregulates a gene that enables protein serine/threonine kinase activity. In a study of macrophages (GSE108897), one such gene showed a log2 fold change of 1.493 and an adjusted p-value of 3.116e-07. Which disease is associated with this specific gene? | patterned macular dystrophy 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06374","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that enables protein serine/threonine kinase activity. In a study of macro... | |
medium_hidden_intermediate_06375 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene that participates in Oncogene Induced Senescence. This gene exhibited a log2 fold change of 3.682 and an adjusted p-value of 1.24e-05. Which protein is encoded by this gene? | Cyclin-dependent kinase 4 inhibitor C | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06375","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_06379 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which in turn encodes a protein that binds to PES1. This gene exhibited a log2 fold change of 3.065 and an adjusted p-value of 2.057e-05. Which protein is encoded by this upregulated gene? | Probable rRNA-processing protein EBP2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06379","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, wh... | |
medium_hidden_intermediate_06382 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to prostate cancer via a biomarker relationship. One of these genes is associated with a study reporting a log2 fold change of approximately 1.20 and an adjusted p-value of approximately 3.56e... | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06382","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship ... | |
medium_hidden_intermediate_06383 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are located in the EARP complex. One of these genes has a reported log2 fold change of 1.137 and an adjusted p-value of 0.00602. Which protein is encoded by this specific gene? | Vacuolar protein sorting-associated protein 53 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06383","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are located in the EARP complex. One ... | |
medium_hidden_intermediate_06385 | Pegivirus C is reported to downregulate a specific gene, which in turn interacts with PRPF19. Experimental data for this intermediate gene in peripheral blood mononuclear cells (from study GSE131504) shows a log2 fold change of approximately -2.06 and an adjusted p-value of 0.001142. Which protein is encoded by this ge... | KH homology domain-containing protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06385","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn interacts with PRPF19. Experimental data for this int... | |
medium_hidden_intermediate_06386 | HIF1AN interacts with a protein that enables protein binding. Evidence regarding one such interacting partner states: 'Using a proteomic approach, we have identified and validated several new E6AP-interacting proteins, including HIF1AN, NEURL4, and mitogen-activated protein kinase 6 (MAPK6).' Which cell type is this sp... | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06386","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"HIF1AN interacts with a protein that enables protein binding. Evidence regarding one such interacting partner states: 'Using... |
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