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medium_hidden_intermediate_06680 | Hepacivirus C upregulates a gene that subsequently interacts with SNAI1. Experimental data for one such intermediate gene reports a log2 fold change of 1.147 and an adjusted p-value of 0.006157. Which protein is encoded by this specific gene? | Early growth response protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06680","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that subsequently interacts with SNAI1. Experimental data for one such intermediate gene re... | |
medium_hidden_intermediate_06681 | Zika virus downregulates a gene that participates in protein folding. Experimental data from glioma stem cells (study GSE114907) indicates this gene has a log2 fold change of -1.876 and an adjusted p-value of 0.01422. Which protein is encoded by this gene? | Kinesin-like protein KIFC3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06681","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in protein folding. Experimental data from glioma stem cells (study GSE114... | |
medium_hidden_intermediate_06682 | Hepacivirus C upregulates a gene that is involved in the positive regulation of cell population proliferation. Evidence for one such gene reports a log2 fold change of 1.087 and an adjusted p-value of 0.000527. Which protein is encoded by that gene? | Dynactin-associated protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06682","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in the positive regulation of cell population proliferation. Evidence for ... | |
medium_hidden_intermediate_06684 | A gene is upregulated by Human gammaherpesvirus 8 and is involved in the negative regulation of the apoptotic process. Experimental data for this gene in a non-Hodgkin lymphoma cell line (study GSE119608) reports a log2 fold change of 1.103 and an adjusted p-value of 0.03305. Which disease is associated with this gene ... | esophageal squamous cell carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06684","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human gammaherpesvirus 8 and is involved in the negative regulation of the apoptotic process. Exper... | |
medium_hidden_intermediate_06685 | PCNA interacts with a protein that is involved in replication fork processing. Experimental evidence indicates that this specific protein remodels DNA structures mimicking stalled replication forks and disassembles recombination intermediates. Which protein is encoded by the gene corresponding to this entity? | DNA annealing helicase and endonuclease ZRANB3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06685","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"PCNA interacts with a protein that is involved in replication fork processing. Experimental evidence indicates that this spe... | |
medium_hidden_intermediate_06688 | A gene is downregulated by Primate bocaparvovirus 1 and is involved in the apoptotic process. Experimental evidence for this gene reports a log2 fold change of approximately -1.17 and an adjusted p-value of approximately 0.03. In which cell type is this gene enriched? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06688","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and is involved in the apoptotic process. Experimental evidence for this... | |
medium_hidden_intermediate_06689 | Human betaherpesvirus 5 is known to upregulate certain genes that are subsequently associated with melanoma. One such gene exhibits a log2 fold change of 1.336 and an adjusted p-value of 0.004919 in a specific study. Which protein does this gene interact with? | RAB4A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06689","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is known to upregulate certain genes that are subsequently associated with melanoma. One such gene e... | |
medium_hidden_intermediate_06690 | Human betaherpesvirus 5 upregulates a gene that is involved in complement activation. Evidence for this specific gene reports a log2 fold change of 1.275 and an adjusted p-value of 0.004219. Which protein is encoded by this gene? | Complement factor B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06690","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that is involved in complement activation. Evidence for this specific gene report... | |
medium_hidden_intermediate_06691 | Pegivirus C is reported to downregulate a gene that enables protein-folding chaperone binding. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -1.89 and an adjusted p-value of approximately 0.0009. Which protein is encoded by this specific gene? | DnaJ homolog subfamily C member 9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06691","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that enables protein-folding chaperone binding. In a study of peripheral bloo... | |
medium_hidden_intermediate_06693 | Human immunodeficiency virus 1 upregulates a gene that enables sequence-specific double-stranded DNA binding. In a study of macrophages (GSE108897), one such gene showed a log2 fold change of approximately 2.443 and an adjusted p-value of 0.0004149. Which gene interacts with the gene identified by these expression stat... | GRHL3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06693","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that enables sequence-specific double-stranded DNA binding. In a study of ... | |
medium_hidden_intermediate_06696 | CHML binds to a specific gene product that enables protein binding. Experimental evidence indicates that RUTBC1 influences the ability of this entity to bind its effector protein, Varp, suggesting a regulatory role for RUTBC1. Which gene interacts with this entity? | PRKAR2A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06696","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"CHML binds to a specific gene product that enables protein binding. Experimental evidence indicates that RUTBC1 influences t... | |
medium_hidden_intermediate_06697 | In bronchial epithelial cells, Severe acute respiratory syndrome-related coronavirus upregulates a specific gene that is involved in the negative regulation of epigenetic gene expression. Evidence for this gene shows a log2 fold change of approximately 1.28 and an adjusted p-value of 0.0028. Which protein is encoded by... | Epidermal retinol dehydrogenase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06697","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In bronchial epithelial cells, Severe acute respiratory syndrome-related coronavirus upregulates a specific gene that is inv... | |
medium_hidden_intermediate_06698 | Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus to preeclampsia via a downregulation followed by an association. One of these genes has a reported log2 fold change of -1.073 and an adjusted p-value of 0.003187. Which protein is encoded by this specific gene? | GA-binding protein alpha chain | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06698","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus to preeclampsia via a downregul... | |
medium_hidden_intermediate_06699 | Zika virus downregulates a specific gene, which is subsequently involved in protein stabilization. Transcriptomic data from glioma stem cells (study GSE114907) indicates that this gene has a log2 fold change of approximately -1.045 and an adjusted p-value of 0.01725. Which protein is encoded by this gene? | T-complex protein 1 subunit beta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06699","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which is subsequently involved in protein stabilization. Transcriptomic data from ... | |
medium_hidden_intermediate_06700 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both bind to SNRPB. One of these genes exhibits a log2 fold change of approximately 1.102 and an adjusted p-value of 0.0009979 in a specific study. Which protein is encoded by this gene? | Gem-associated protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06700","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both bind to SNRPB. One of these gene... | |
medium_hidden_intermediate_06703 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with ITCH. One of these genes shows a log2 fold change of 1.772 and an adjusted p-value of 0.002988 in a specific study. Which cellular component is this gene located in? | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06703","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with ITCH. One of these gene... | |
medium_hidden_intermediate_06705 | Zika virus downregulates a specific gene, which in turn interacts with GOLPH3. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -2.960 and an adjusted p-value of 0.002873. Which protein is encoded by this gene? | Divergent protein kinase domain 2A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06705","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with GOLPH3. Experimental data for this gene in glioma ste... | |
medium_hidden_intermediate_06706 | Zika virus downregulates a gene that is involved in the negative regulation of the ceramide biosynthetic process. Experimental data from glioma stem cells (study GSE114907) indicate that this gene has a log2 fold change of approximately -1.083 and an adjusted p-value of 0.01408. Which protein is encoded by this gene? | ORM1-like protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06706","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is involved in the negative regulation of the ceramide biosynthetic process. Experiment... | |
medium_hidden_intermediate_06707 | Severe acute respiratory syndrome-related coronavirus downregulates a gene involved in lipid phosphorylation. Evidence for one such gene reports a log2 fold change of -1.953 and an adjusted p-value of 0.0343. Which protein is encoded by that gene? | Diacylglycerol kinase iota | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06707","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene involved in lipid phosphorylation. Evidence for o... | |
medium_hidden_intermediate_06708 | Two genes are linked to Vaccinia virus via an upregulation relationship and are both involved in the positive regulation of osteoblast differentiation. One of these genes exhibits a log2 fold change of 1.722 and an adjusted p-value of 9.792e-08 in cervical adenocarcinoma cell lines (study GSE11238). Which protein is en... | Beta-catenin-interacting protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06708","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Vaccinia virus via an upregulation relationship and are both involved in the positive regulation of ... | |
medium_hidden_intermediate_06709 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with breast carcinoma through genomic alterations. One of these genes was reported in a study (GSE155241) involving lung cells, with a log2 fold change of approximately 1.46 and an adjusted p-value of approximately 0.0... | systemic lupus erythematosus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06709","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with breast carcinoma ... | |
medium_hidden_intermediate_06710 | Human immunodeficiency virus 1 downregulates a gene that is located in the extracellular matrix. Evidence for one such gene reports a log2 fold change of -3.011 and an adjusted p-value of 0.008319. Which disease is associated with this gene as a biomarker? | lung adenocarcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06710","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is located in the extracellular matrix. Evidence for one such gene ... | |
medium_hidden_intermediate_06711 | Human immunodeficiency virus 1 upregulates a gene that is involved in the regulation of transcription by RNA polymerase II. Evidence for this specific gene reports a log2 fold change of 1.270 and an adjusted p-value of 0.0001644. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06711","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in the regulation of transcription by RNA polymerase II. ... | |
medium_hidden_intermediate_06712 | In a study of Dengue virus infection in a hepatoma cell line (GSE110512), a specific gene is downregulated by the virus and is associated with protein homodimerization activity. This gene exhibits a log2 fold change of -2.066 and an adjusted p-value of 0.01698. Which protein is encoded by this gene? | Zinc finger and BTB domain-containing protein 38 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06712","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Dengue virus infection in a hepatoma cell line (GSE110512), a specific gene is downregulated by the virus and ... | |
medium_hidden_intermediate_06713 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific gene, which in turn is associated with signaling receptor binding. This gene exhibited a log2 fold change of -1.114 and an adjusted p-value of 0.01145. Which protein is encoded by this gene? | Ankyrin repeat domain-containing protein 13C | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06713","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific g... | |
medium_hidden_intermediate_06716 | In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upregulate a gene that enables protein serine/threonine kinase activity. One such gene exhibited a log2 fold change of approximately 1.59 and an adjusted p-value of 0.01058. Which cellular component is... | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06716","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cardiomyocyte cell lines (GSE151879), Severe acute respiratory syndrome-related coronavirus was found to upreg... | |
medium_hidden_intermediate_06718 | Hepacivirus C is reported to downregulate a gene that enables sequence-specific double-stranded DNA binding. Experimental data for one such gene shows a log2 fold change of -1.635 and an adjusted p-value of 0.005085. Which protein is encoded by this gene? | Zinc finger protein 449 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06718","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that enables sequence-specific double-stranded DNA binding. Experimental da... | |
medium_hidden_intermediate_06719 | Enterovirus A is reported to downregulate a specific gene, which in turn participates in axon guidance. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) indicate a log2 fold change of -3.189 and an adjusted p-value of 0.008911. Which disease is associated with genomic alterations in this gene... | Turner syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06719","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to downregulate a specific gene, which in turn participates in axon guidance. Experimental data fo... | |
medium_hidden_intermediate_06721 | Measles morbillivirus upregulates a gene that interacts with CEP63. One such gene exhibits a log2 fold change of 1.232 and an adjusted p-value of 0.02068. Which protein is encoded by this gene? | Gamma-taxilin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06721","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that interacts with CEP63. One such gene exhibits a log2 fold change of 1.232 and a... | |
medium_hidden_intermediate_06722 | Two genes are upregulated by Measles morbillivirus and are enriched in Mucosa-associated invariant T (MAIT) cells. One of these genes exhibits a log2 fold change of 3.836 and an adjusted p-value of 0.008117. Which biological process is this specific gene involved in? | negative regulation of transcription by RNA polymerase II | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06722","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Measles morbillivirus and are enriched in Mucosa-associated invariant T (MAIT) cells. One of th... | |
medium_hidden_intermediate_06723 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes involved in signal transduction. One such gene exhibits a log2 fold change of approximately -1.164 and an adjusted p-value of 0.001615. Which protein is encoded by this specific gene? | Dual specificity protein phosphatase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06723","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes invol... | |
medium_hidden_intermediate_06724 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to Transcriptional Regulation by TP53 via a 'participates in' relationship. One of these genes has an associated expression profile showing a log2 fold change of -1.438 and an adjusted p-val... | Sestrin-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06724","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_06726 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in SARS-CoV Infections. Experimental data for this gene reports a log2 fold change of 9.327 and an adjusted p-value of 0.02494. Which protein is encoded by this gene? | Interferon alpha-5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06726","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in SARS-CoV Infections. Expe... | |
medium_hidden_intermediate_06727 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables ubiquitin protein ligase binding. Evidence for this gene reports a log2 fold change of 2.722 and an adjusted p-value of 0.00792. Which cell type is this gene enriched in? | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06727","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables ubiquitin protein ligase binding. Evid... | |
medium_hidden_intermediate_06729 | Rift Valley fever phlebovirus upregulates a gene that is enriched in neutrophils. One such gene exhibits a log2 fold change of 1.643 and an adjusted p-value of 0.01108 in SAEC cells (study GSE102481). Which protein does this specific gene interact with? | STAT3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06729","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rift Valley fever phlebovirus upregulates a gene that is enriched in neutrophils. One such gene exhibits a log2 fold change ... | |
medium_hidden_intermediate_06732 | A gene is downregulated by Vaccinia virus and participates in HCMV Late Events. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) shows a log2 fold change of -3.348 and an adjusted p-value of 0.01577. In which cell type is this gene enriched? | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06732","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Vaccinia virus and participates in HCMV Late Events. Experimental data for this gene in a cervica... | |
medium_hidden_intermediate_06734 | Nerve Sheath Neoplasms are localized to an ectoderm-derived structure. One such structure is described as a cranial nerve fiber tract comprised of retinal ganglion cell axons running posterior medially towards the optic chiasm, where some axons cross the midline, after which the structure is termed the optic tract, tra... | retinal neural layer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06734","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Nerve Sheath Neoplasms are localized to an ectoderm-derived structure. One such structure is described as a cranial nerve fi... | |
medium_hidden_intermediate_06735 | Zika virus downregulates multiple genes that are located in the early endosome. One such gene exhibits a log2 fold change of -3.384 and an adjusted p-value of 0.00257 in glioma stem cells. Which protein is encoded by this specific gene? | Amyloid beta precursor protein binding family B member 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06735","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates multiple genes that are located in the early endosome. One such gene exhibits a log2 fold change of... | |
medium_hidden_intermediate_06737 | Human alphaherpesvirus 1 upregulates a gene that is located in the extracellular region. Evidence for one such gene reports a log2 fold change of 1.240 and an adjusted p-value of 0.008148. Which protein is encoded by that gene? | Gamma-interferon-inducible lysosomal thiol reductase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06737","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that is located in the extracellular region. Evidence for one such gene reports ... | |
medium_hidden_intermediate_06738 | Human betaherpesvirus 5 is reported to downregulate a gene that participates in Hemostasis. Evidence for this gene shows a log2 fold change of approximately -1.064 and an adjusted p-value of 0.0444. Which cell type is this gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06738","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that participates in Hemostasis. Evidence for this gene shows a l... | |
medium_hidden_intermediate_06739 | Human immunodeficiency virus 1 downregulates a gene that interacts with YWHAH. In a study of macrophages (GSE108897), one such gene exhibits a log2 fold change of approximately -1.57 and an adjusted p-value of approximately 0.030. Which protein is encoded by this gene? | Cordon-bleu protein-like 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06739","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that interacts with YWHAH. In a study of macrophages (GSE108897), one su... | |
medium_hidden_intermediate_06742 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to colorectal carcinoma via a biomarker relationship. One of these genes is associated with a log2 fold change of 1.165 and an adjusted p-value of 0.0358. Which cell type is enriched for this specific gene... | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06742","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to colore... | |
medium_hidden_intermediate_06744 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables signaling receptor activity. Experimental data for this gene reports a log2 fold change of 1.394 and an adjusted p-value of 0.0137. Which protein is encoded by this gene? | Reticulon-4 receptor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06744","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables signaling receptor activity. Expe... | |
medium_hidden_intermediate_06745 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in chromatin organization. Evidence for this gene shows a log2 fold change of approximately 2.02 and an adjusted p-value of approximately 0.036. Which protein does this gene interact with? | H3-4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06745","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in chromatin organization. Eviden... | |
medium_hidden_intermediate_06748 | Two genes are upregulated by Human immunodeficiency virus 1 and interact with RAB11A. One of these genes exhibits a log2 fold change of 1.644 and an adjusted p-value of 0.007739 in a specific study. Which disease is associated with this gene? | melanoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06748","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and interact with RAB11A. One of these genes exhibits a log2 fol... | |
medium_hidden_intermediate_06751 | A gene is upregulated by Human immunodeficiency virus 1 and located in the endoplasmic reticulum membrane. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of 3.757 and an adjusted p-value of 0.004489. Which disease is associated with this gene as a biomarker? | endometriosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06751","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human immunodeficiency virus 1 and located in the endoplasmic reticulum membrane. Evidence for this... | |
medium_hidden_intermediate_06753 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), a specific gene is downregulated by the virus and is involved in intracellular signal transduction. This gene exhibits a log2 fold change of -1.676 and an adjusted p-value of 0.0002744. Which protein does this gene... | RANBP2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06753","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), a specific gene is... | |
medium_hidden_intermediate_06756 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus was found to upregulate a gene that enables enzyme binding. This specific gene exhibited a log2 fold change of approximately 1.005 and an adjusted p-value of 0.01604. Which protein is encoded by this gene? | Protein mono-ADP-ribosyltransferase PARP14 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06756","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus was found to upregulate a gene that enables enzy... | |
medium_hidden_intermediate_06759 | Two genes are downregulated by Pegivirus C and are enriched in conventional dendritic cells. One of these genes exhibits a log2 fold change of approximately -1.65 and an adjusted p-value of approximately 0.011 in peripheral blood mononuclear cells from study GSE131504. Which disease is associated with this specific gen... | aspergillosis, susceptibility to | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06759","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and are enriched in conventional dendritic cells. One of these genes exhibits a l... | |
medium_hidden_intermediate_06760 | Two genes are upregulated by Human immunodeficiency virus 1 and are associated with gastric cancer. One of these genes exhibits a log2 fold change of 1.825 and an adjusted p-value of 0.01028 in macrophages (study GSE108897). Which disease is linked to this specific gene through genomic alterations? | lung cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06760","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and are associated with gastric cancer. One of these genes exhib... | |
medium_hidden_intermediate_06762 | Human betaherpesvirus 5 is linked to liver cancer via a downregulation relationship with an intermediate entity that serves as a biomarker for the disease. One such intermediate entity was reported in a study (GSE132081) using foreskin fibroblast cell lines, showing a log2 fold change of approximately -2.13 and an adju... | Macrophage immunometabolism regulator | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06762","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is linked to liver cancer via a downregulation relationship with an intermediate entity that serves ... | |
medium_hidden_intermediate_06763 | Zika virus downregulates a gene that enables DNA-binding transcription activator activity, RNA polymerase II-specific. Evidence for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -2.141 and an adjusted p-value of 0.04591. Which disease is associated with this gene as a biomarker? | colon carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06763","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that enables DNA-binding transcription activator activity, RNA polymerase II-specific. Evide... | |
medium_hidden_intermediate_06766 | Pegivirus C is reported to downregulate a gene that is involved in the cellular response to unfolded protein. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.611 and an adjusted p-value of 0.002321. Which protein is encoded by this specific gene? | Transmembrane 7 superfamily member 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06766","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in the cellular response to unfolded protein. In a study of ... | |
medium_hidden_intermediate_06767 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Cytokine Signaling in Immune system. Experimental data for this gene shows a log2 fold change of -1.690 and an adjusted p-value of 0.03861. Which disease is associated with this gene as a biomarker? | urinary bladder carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06767","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Cytokine Signaling in I... | |
medium_hidden_intermediate_06768 | Cardiovirus A upregulates a gene that participates in Interferon Signaling. Evidence for this gene reports a log2 fold change of approximately 1.065 and an adjusted p-value of approximately 0.0167. Which cell type is this gene enriched in? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06768","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A upregulates a gene that participates in Interferon Signaling. Evidence for this gene reports a log2 fold chang... | |
medium_hidden_intermediate_06769 | EP300 interacts with a protein that is located in the membrane. Evidence regarding one such interacting partner states: 'We show that the interaction between E2 and hNAP-1 is direct and not merely mediated by the transcriptional coactivator p300, which is bound by both proteins.' Which protein is encoded by the gene co... | Nucleosome assembly protein 1-like 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06769","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"EP300 interacts with a protein that is located in the membrane. Evidence regarding one such interacting partner states: 'We ... | |
medium_hidden_intermediate_06770 | The humerus is a type of a specific anatomical entity, which is in turn a part of the forelimb stylopod. Evidence for this entity describes it as a 'Paired endochondral long bone that extends between the pectoral girdle and the skeletal parts of the forelimb.' Which anatomical category is this specific entity a type of... | arm bone | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06770","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"The humerus is a type of a specific anatomical entity, which is in turn a part of the forelimb stylopod. Evidence for this e... | |
medium_hidden_intermediate_06772 | Zika virus upregulates a specific gene that enables identical protein binding. In a study of neural stem cells (GSE129180), this gene exhibited a log2 fold change of approximately 2.47 and an adjusted p-value of approximately 0.024. Which biological process is this gene involved in? | endothelial cell migration | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06772","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a specific gene that enables identical protein binding. In a study of neural stem cells (GSE129180), ... | |
medium_hidden_intermediate_06773 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Potassium Channels. Evidence for one such gene reports a log2 fold change of 2.265 and an adjusted p-value of 0.004766. Which protein is encoded by that gene? | Small conductance calcium-activated potassium channel protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06773","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in Potassium Channels. Evidence f... | |
medium_hidden_intermediate_06775 | In a study of vascular endothelial cells (GSE16354), a gene is downregulated by Human gammaherpesvirus 8 and associated with leukemia. This gene exhibits a log2 fold change of approximately -2.315 and an adjusted p-value of 0.01592. Which protein does this gene product bind to? | TYROBP | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06775","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of vascular endothelial cells (GSE16354), a gene is downregulated by Human gammaherpesvirus 8 and associated with... | |
medium_hidden_intermediate_06777 | Two genes are downregulated by Pegivirus C and interact with YWHAG. One of these genes exhibits a log2 fold change of -1.062 and an adjusted p-value of 0.006038 in peripheral blood mononuclear cells. Which protein is encoded by this specific gene? | PABIR family member 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06777","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and interact with YWHAG. One of these genes exhibits a log2 fold change of -1.062... | |
medium_hidden_intermediate_06778 | Pegivirus C is reported to downregulate a gene that is involved in chromatin remodeling. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -1.67 and an adjusted p-value of approximately 0.0017. Which protein is encoded by this specific gene? | Nuclear factor related to kappa-B-binding protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06778","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in chromatin remodeling. In a study of peripheral blood mono... | |
medium_hidden_intermediate_06780 | Measles morbillivirus upregulates a gene that enables DNA-binding transcription repressor activity, RNA polymerase II-specific. One such gene exhibits a log2 fold change of 1.950 and an adjusted p-value of 0.002987 in study GSE131840. Which disease is associated with this gene through genomic alterations? | amyotrophic lateral sclerosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06780","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that enables DNA-binding transcription repressor activity, RNA polymerase II-specif... | |
medium_hidden_intermediate_06781 | Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus via downregulation and onward to gastric cancer via genomic alterations. One of these genes is associated with a log2 fold change of -1.693 and an adjusted p-value of 5.121e-05. Which cell type is enriched for that specific gen... | regulatory T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06781","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus via downregulation and onward t... | |
medium_hidden_intermediate_06786 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in immunoregulatory interactions between a lymphoid and a non-lymphoid cell. Evidence for one such gene reports a log2 fold change of 3.153 and an adjusted p-value of 0.002761. Which disease is associated with that gene? | colon carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06786","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in immunoregulatory interactions ... | |
medium_hidden_intermediate_06787 | Human betaherpesvirus 5 upregulates a gene that participates in G alpha (i) signalling events. Experimental data for this gene reports a log2 fold change of 2.077 and an adjusted p-value of 5.355e-06. Which disease is associated with this gene through genomic alterations? | migraine disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06787","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in G alpha (i) signalling events. Experimental data for this ge... | |
medium_hidden_intermediate_06788 | Human immunodeficiency virus 1 upregulates a gene that participates in the RHO GTPase cycle. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of 1.507 and an adjusted p-value of 0.0003728. Which protein is encoded by this gene? | Serine/threonine-protein kinase N3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06788","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in the RHO GTPase cycle. In a study of macrophages (GSE1... | |
medium_hidden_intermediate_06789 | A gene is downregulated by Vaccinia virus and serves as a biomarker for multiple sclerosis. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of -1.528 and an adjusted p-value of 0.009691. Which protein is encoded by this gene? | G-protein coupled receptor 183 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06789","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Vaccinia virus and serves as a biomarker for multiple sclerosis. Experimental data for this gene ... | |
medium_hidden_intermediate_06790 | Human betaherpesvirus 5 upregulates a gene that participates in the Innate Immune System. Experimental data for this gene shows a log2 fold change of 1.069 and an adjusted p-value of 1.789e-05. Which cellular component is this gene located in? | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06790","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in the Innate Immune System. Experimental data for this gene sh... | |
medium_hidden_intermediate_06793 | In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and involved in mitochondrial calcium ion homeostasis. This gene exhibits a log2 fold change of 3.276 and an adjusted p-value of 1.47e-17. Which protein is encoded by this gene? | Calcium uptake protein 3, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06793","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cells infected with Influenza A virus, a specific gene is upregulated and i... | |
medium_hidden_intermediate_06799 | Human betaherpesvirus 5 is known to downregulate certain genes that enable GTP binding. One such gene exhibits a log2 fold change of approximately -1.196 and an adjusted p-value of 0.04705 in foreskin fibroblast cell lines. Which disease is associated with this specific gene as a biomarker? | amyotrophic lateral sclerosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06799","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is known to downregulate certain genes that enable GTP binding. One such gene exhibits a log2 fold c... | |
medium_hidden_intermediate_06802 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in midbody abscission. Experimental data for this gene reports a log2 fold change of 1.366 and an adjusted p-value of 0.007264. Which protein is encoded by this gene? | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06802","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in midbody abscission. Experi... | |
medium_hidden_intermediate_06804 | Measles morbillivirus upregulates a gene that interacts with MYC. One such gene exhibits a log2 fold change of approximately 3.55 and an adjusted p-value of approximately 0.0002. Which protein is encoded by this gene? | Kinesin-like protein KIF18B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06804","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that interacts with MYC. One such gene exhibits a log2 fold change of approximately... | |
medium_hidden_intermediate_06806 | Hepacivirus C upregulates a gene that participates in the regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). Evidence for one such gene reports a log2 fold change of 1.437 and an adjusted p-value of 0.03916. Which cell type is this gene enriched ... | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06806","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in the regulation of Insulin-like Growth Factor (IGF) transport and uptak... | |
medium_hidden_intermediate_06809 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to Alzheimer disease via a biomarker relationship. One of these genes is reported in a study (GSE151879) involving cardiomyocyte cell lines, with a log2 fold change of approximately 4.49 and an adjusted p-... | extracellular space | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06809","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to Alzhei... | |
medium_hidden_intermediate_06810 | In a study of Hepacivirus C infection in peripheral blood mononuclear cells (GSE119117), two genes are downregulated by the virus and subsequently bind to YWHAQ. One of these genes exhibits a log2 fold change of -1.224 and an adjusted p-value of 0.006248. Which protein is encoded by this specific gene? | DNA damage-inducible transcript 4 protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06810","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Hepacivirus C infection in peripheral blood mononuclear cells (GSE119117), two genes are downregulated by the ... | |
medium_hidden_intermediate_06811 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that participates in muscle contraction. One such gene exhibited a log2 fold change of approximately 6.46 and an adjusted p-value of 0.00085. Which protein is encoded by this specific gene? | Sodium/calcium exchanger 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06811","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that pa... | |
medium_hidden_intermediate_06812 | Human betaherpesvirus 5 is reported to downregulate a gene that is involved in the regulation of cell population proliferation. In a study of foreskin fibroblast cell lines (GSE111036), one such gene exhibits a log2 fold change of approximately -1.15 and an adjusted p-value of 0.0233. Which protein is encoded by this s... | Tumor protein D54 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06812","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that is involved in the regulation of cell population proliferati... | |
medium_hidden_intermediate_06813 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to downregulate a gene that enables metallopeptidase activity. One such gene exhibited a log2 fold change of -1.913 and an adjusted p-value of 0.01468. Which protein is encoded by this specific gene? | A disintegrin and metalloproteinase with thrombospondin motifs 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06813","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to downregulate a gene that enables meta... | |
medium_hidden_intermediate_06814 | Two genes are linked to Human alphaherpesvirus 3 via upregulation and to cystic fibrosis via association. One of these genes exhibits a log2 fold change of 1.244 and an adjusted p-value of 0.0444 in a specific study. Which cell type is enriched for this specific gene? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06814","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Human alphaherpesvirus 3 via upregulation and to cystic fibrosis via association. One of these genes... | |
medium_hidden_intermediate_06816 | Two genes are linked to Pegivirus C via downregulation and to pediatric osteosarcoma via biomarker association. One of these genes exhibits a log2 fold change of -1.781 and an adjusted p-value of 0.00153 in peripheral blood mononuclear cells (study GSE131504). Which biological process is this specific gene involved in? | GPI anchor biosynthetic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06816","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Pegivirus C via downregulation and to pediatric osteosarcoma via biomarker association. One of these... | |
medium_hidden_intermediate_06817 | Zika virus downregulates a specific gene that participates in the translation of structural proteins. Experimental data from glioma stem cells (study GSE114907) indicates this gene has a log2 fold change of approximately -1.20 and an adjusted p-value of approximately 0.031. In which cellular component is this gene prod... | endoplasmic reticulum | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06817","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in the translation of structural proteins. Experimental data from... | |
medium_hidden_intermediate_06818 | In a study of rhabdomyosarcoma cells infected with Enterovirus A, a specific gene is upregulated by the virus and localized to chromatin. This gene exhibits a log2 fold change of approximately 1.65 and an adjusted p-value of 0.02124. Which biological process is this gene involved in? | DNA replication-dependent chromatin assembly | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06818","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells infected with Enterovirus A, a specific gene is upregulated by the virus and localized ... | |
medium_hidden_intermediate_06819 | A gene is upregulated by Measles morbillivirus and enriched in Regulatory T (Treg) cells. Evidence for this gene reports a log2 fold change of 1.295 and an adjusted p-value of 0.01617. Which cellular component is this gene located in? | mitochondrial outer membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06819","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and enriched in Regulatory T (Treg) cells. Evidence for this gene reports a l... | |
medium_hidden_intermediate_06821 | Human polyomavirus 1 upregulates a gene that is located in the nucleus. Evidence for this gene reports a log2 fold change of 1.399 and an adjusted p-value of 0.02003. In which cell type is this gene enriched? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06821","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human polyomavirus 1 upregulates a gene that is located in the nucleus. Evidence for this gene reports a log2 fold change of... | |
medium_hidden_intermediate_06822 | A gene is downregulated by Zika virus and binds to SURF4. Experimental data for this gene in glioma stem cells reports a log2 fold change of approximately -1.205 and an adjusted p-value of 0.04421. In which cell type is this gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06822","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Zika virus and binds to SURF4. Experimental data for this gene in glioma stem cells reports a log... | |
medium_hidden_intermediate_06823 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via downregulation and to kidney Wilms tumor via association. One of these genes exhibits a log2 fold change of -4.999 and an adjusted p-value of 0.01751 in a specific study. Which protein is encoded by this gene? | Hyaluronan synthase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06823","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via downregulation and to kidney Wilms tumor v... | |
medium_hidden_intermediate_06824 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with gastric carcinoma. One of these genes exhibits a log2 fold change of 1.748 and an adjusted p-value of 0.0064 in a specific study. Which cellular component is the location of this specific gene? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06824","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with gastric carcinoma... | |
medium_hidden_intermediate_06827 | Enterovirus A is reported to downregulate a specific gene that participates in the metabolism of proteins. In a study of rhabdomyosarcoma cells (GSE103308), this gene exhibited a log2 fold change of approximately -1.045 and an adjusted p-value of 0.0408. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06827","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to downregulate a specific gene that participates in the metabolism of proteins. In a study of rha... | |
medium_hidden_intermediate_06832 | Zika virus downregulates a specific gene, which in turn interacts with CCNB1. Experimental data from glioma stem cells (study GSE114907) indicates that this gene has a log2 fold change of -1.630 and an adjusted p-value of 0.01926. Which protein is encoded by this gene? | Testis-specific Y-encoded-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06832","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with CCNB1. Experimental data from glioma stem cells (stud... | |
medium_hidden_intermediate_06833 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in autophagosome assembly. Evidence for this gene reports a log2 fold change of approximately 1.945 and an adjusted p-value of 0.04434. Which disease is associated with this gene as a biomarker? | glioma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06833","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is involved in autophagosome assembly. Ev... | |
medium_hidden_intermediate_06834 | Two genes are upregulated by Human immunodeficiency virus 1 and serve as biomarkers for bipolar disorder. One of these genes exhibits a log2 fold change of approximately 1.158 and an adjusted p-value of 0.01115 in macrophages (study GSE108897). Which disease is associated with this specific gene? | tuberculosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06834","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and serve as biomarkers for bipolar disorder. One of these genes... | |
medium_hidden_intermediate_06835 | A gene is upregulated by Human gammaherpesvirus 8 and located in the mitochondrion. Evidence for this gene in a non-Hodgkin lymphoma cell line (study GSE119608) reports a log2 fold change of 3.238 and an adjusted p-value of 0.02486. Which disease is associated with this gene through genomic alterations? | cutaneous melanoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06835","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human gammaherpesvirus 8 and located in the mitochondrion. Evidence for this gene in a non-Hodgkin ... | |
medium_hidden_intermediate_06836 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and participates in Cell-Cell communication. Evidence for this gene reports a log2 fold change of approximately 1.85 and an adjusted p-value of approximately 0.022. Which protein is encoded by this gene? | Beta-parvin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06836","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and participat... | |
medium_hidden_intermediate_06837 | Zaire ebolavirus downregulates a gene that participates in Membrane Trafficking. In a study of retinal pigment epithelium cells (GSE100839), one such gene showed a log2 fold change of approximately -1.44 and an adjusted p-value of approximately 0.04. Which protein is encoded by this gene? | Ras-related protein Rab-33A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06837","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus downregulates a gene that participates in Membrane Trafficking. In a study of retinal pigment epithelium ce... | |
medium_hidden_intermediate_06838 | Zika virus downregulates a specific gene that is associated with breast carcinoma. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of approximately -1.266 and an adjusted p-value of 0.01401. What molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06838","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is associated with breast carcinoma. In a study of glioma stem cells (GSE11490... | |
medium_hidden_intermediate_06839 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which subsequently interacts with VCP. This gene exhibits a log2 fold change of approximately -1.009 and an adjusted p-value of 0.0119. Which biological process is this gene involved in? | ERAD pathway | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06839","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_06841 | Human immunodeficiency virus 1 upregulates a gene that participates in cell surface interactions at the vascular wall. In a study of macrophages (GSE108897), one such gene was found to have a log2 fold change of approximately 1.586 and an adjusted p-value of approximately 2.405e-05. Which protein does this specific gen... | CDC42 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06841","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in cell surface interactions at the vascular wall. In a ... | |
medium_hidden_intermediate_06842 | Zika virus downregulates a specific gene that is involved in the regulation of transcription by RNA polymerase II. Experimental data from glioma stem cells (study GSE114907) indicates that this gene has a log2 fold change of -2.141 and an adjusted p-value of 0.04591. Which disease is associated with this gene as a biom... | colon carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06842","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is involved in the regulation of transcription by RNA polymerase II. Experimen... | |
medium_hidden_intermediate_06843 | TRIM33 interacts with a specific protein that enables protein binding. Evidence indicates that TRIM33 binds this protein directly and induces its ubiquitination at lysine 218 upon dsRNA stimulation. Which disease is associated with this protein as a biomarker? | hepatocellular carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06843","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"TRIM33 interacts with a specific protein that enables protein binding. Evidence indicates that TRIM33 binds this protein dir... |
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