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medium_hidden_intermediate_06387 | Vaccinia virus downregulates a gene that is enriched in plasmacytoid dendritic cells. Evidence for one such gene reports a log2 fold change of -1.377 and an adjusted p-value of 0.03558. Which protein is encoded by that gene? | Sterile alpha motif domain-containing protein 12 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06387","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus downregulates a gene that is enriched in plasmacytoid dendritic cells. Evidence for one such gene reports a l... | |
medium_hidden_intermediate_06388 | Hepacivirus C upregulates a gene that participates in phospholipid metabolism. Evidence for one such gene reports a log2 fold change of 1.741 and an adjusted p-value of 1.279e-05. Which disease is associated with that gene? | myeloid leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06388","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in phospholipid metabolism. Evidence for one such gene reports a log2 fol... | |
medium_hidden_intermediate_06389 | In a study of Hepacivirus C infection, a specific gene is downregulated and serves as a biomarker for disease. Evidence for this gene reports a log2 fold change of approximately -1.18 and an adjusted p-value of approximately 0.027. Which protein is encoded by this gene? | Serine/threonine-protein kinase N3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06389","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Hepacivirus C infection, a specific gene is downregulated and serves as a biomarker for disease. Evidence for ... | |
medium_hidden_intermediate_06390 | Human betaherpesvirus 5 is known to downregulate certain genes that enable identical protein binding. In a study of foreskin fibroblast cell lines (GSE111036), one such gene exhibited a log2 fold change of -1.713 and an adjusted p-value of 0.0288. Which protein interacts with this specific gene product? | UTP25 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06390","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is known to downregulate certain genes that enable identical protein binding. In a study of foreskin... | |
medium_hidden_intermediate_06391 | In a study of glioma stem cells (GSE114907), Zika virus downregulates a specific gene, which in turn binds to TGFA. This gene exhibits a log2 fold change of -2.451 and an adjusted p-value of 0.02512. Which protein is encoded by this gene? | Cyclin-G-associated kinase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06391","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), Zika virus downregulates a specific gene, which in turn binds to TGFA. This gen... | |
medium_hidden_intermediate_06392 | Zika virus downregulates a gene that participates in cellular responses to stress. Evidence for this gene reports a log2 fold change of -1.119 and an adjusted p-value of 0.02621. Which protein is encoded by this gene? | Polyhomeotic-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06392","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in cellular responses to stress. Evidence for this gene reports a log2 fol... | |
medium_hidden_intermediate_06393 | BRCA1 interacts with a specific gene product that enables protein binding. Evidence indicates this entity interacts with RNA polymerase II (Pol II) and inhibits the transcription of protein-encoding genes through an unknown mechanism. Which protein is encoded by this gene? | ATP-dependent DNA helicase Q5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06393","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"BRCA1 interacts with a specific gene product that enables protein binding. Evidence indicates this entity interacts with RNA... | |
medium_hidden_intermediate_06394 | A specific gene is identified as a marker for Natural killer T (NKT) cells and is involved in potassium ion transmembrane transport. Evidence indicates that the protein product of this gene comprises a K(+) channel that underlies the molecular mechanism of lysosomal K(+) permeability. Which protein is encoded by this g... | Endosomal/lysosomal proton channel TMEM175 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06394","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A specific gene is identified as a marker for Natural killer T (NKT) cells and is involved in potassium ion transmembrane tr... | |
medium_hidden_intermediate_06395 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables transcription regulator inhibitor activity. Evidence for one such gene reports a log2 fold change of 3.336 and an adjusted p-value of 4.2e-10. Which protein is encoded by that gene? | DNA-binding protein inhibitor ID-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06395","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables transcription regulator inhibitor acti... | |
medium_hidden_intermediate_06396 | A gene is downregulated by Cardiovirus A and participates in the Immune System. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of approximately -1.637 and an adjusted p-value of approximately 0.025. Which disease is associated with this gene? | Malignant tumor of esophagus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06396","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Cardiovirus A and participates in the Immune System. Experimental data for this gene in a cervica... | |
medium_hidden_intermediate_06397 | Human immunodeficiency virus 1 upregulates a gene that participates in hemostasis. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of 3.798 and an adjusted p-value of 0.002942. Which protein is encoded by this gene? | Proteinase-activated receptor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06397","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that participates in hemostasis. In a study of macrophages (GSE108897), th... | |
medium_hidden_intermediate_06398 | CHML binds to a specific small GTPase that enables protein binding. Evidence identifies this GTPase as a key regulator that recruits the HOPS complex onto autophagic vesicles. Which protein is encoded by this gene? | Ras-related protein Rab-39A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06398","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"CHML binds to a specific small GTPase that enables protein binding. Evidence identifies this GTPase as a key regulator that ... | |
medium_hidden_intermediate_06399 | Two genes are both upregulated by Influenza A virus and enriched in intermediate monocytes. One of these genes exhibits a log2 fold change of 1.839 and an adjusted p-value of 0.008354 in a specific study. Which disease is associated with genomic alterations in that specific gene? | lymphoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06399","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are both upregulated by Influenza A virus and enriched in intermediate monocytes. One of these genes exhibits a lo... | |
medium_hidden_intermediate_06400 | Two genes are structurally linked from Pegivirus C via a downregulation relationship and subsequently to Platelet activation, signaling and aggregation via a participation relationship. One of these genes exhibits a log2 fold change of -2.163 and an adjusted p-value of 0.003609 in peripheral blood mononuclear cells. Wh... | cannabis dependence | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06400","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Pegivirus C via a downregulation relationship and subsequently to Platelet activation... | |
medium_hidden_intermediate_06403 | Vaccinia virus infection leads to the upregulation of genes whose protein products are located in the apical plasma membrane. One such gene exhibits a log2 fold change of 3.948 and an adjusted p-value of 9.225e-09 in cervical adenocarcinoma cells. Which protein is encoded by this specific gene? | Large neutral amino acids transporter small subunit 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06403","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus infection leads to the upregulation of genes whose protein products are located in the apical plasma membrane... | |
medium_hidden_intermediate_06405 | Rhinovirus A infection leads to the downregulation of specific genes involved in SLC-mediated transmembrane transport. In a study of cytotoxic T-lymphocytes (GSE106475), one such downregulated gene exhibited a log2 fold change of approximately -1.04 and an adjusted p-value of 0.001478. Which protein is encoded by this ... | Choline transporter-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06405","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection leads to the downregulation of specific genes involved in SLC-mediated transmembrane transport. In a ... | |
medium_hidden_intermediate_06406 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both interact with XRCC5. One of these genes exhibits a log2 fold change of 1.620 and an adjusted p-value of 0.0306 in a specific study. Which disease is associated with this specific gene? | Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06406","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both interact with XRCC5. One of thes... | |
medium_hidden_intermediate_06407 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes involved in glycosaminoglycan metabolism. One such gene exhibited a log2 fold change of approximately 2.705 and an adjusted p-value of 0.04848. Which protein is encoded by this specific gene? | Type 2 lactosamine alpha-2,3-sialyltransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06407","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes involved in ... | |
medium_hidden_intermediate_06408 | Two genes are structurally linked to Measles morbillivirus via an upregulation relationship and to HIST1H2BG via an interaction relationship. One of these genes is reported in a study (GSE117668) involving pleural mesothelioma cells, with a log2 fold change of 3.661 and an adjusted p-value of 0.0004943. Which disease i... | prostate carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06408","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Measles morbillivirus via an upregulation relationship and to HIST1H2BG via an interact... | |
medium_hidden_intermediate_06409 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in diseases of signal transduction by growth factor receptors and second messengers. Evidence for one such gene reports a log2 fold change of 1.370 and an adjusted p-value of 0.03378. Which protein is encoded by that gene? | Transcription factor HES-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06409","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in diseases of signal transductio... | |
medium_hidden_intermediate_06410 | Two genes are associated with Natural killer T (NKT) cells as markers and both enable actin filament binding. One of these genes is characterized by evidence stating that its adducin tail domains alone are sufficient to interact with F-actin and a single spectrin, and to recruit additional spectrin molecules to the ter... | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06410","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are associated with Natural killer T (NKT) cells as markers and both enable actin filament binding. One of these g... | |
medium_hidden_intermediate_06411 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that participates in the alpha-oxidation of phytanate. One such gene exhibited a log2 fold change of approximately 2.096 and an adjusted p-value of 0.0001072. Which protein is encoded by this specific ge... | Peroxisomal trans-2-enoyl-CoA reductase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06411","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that pa... | |
medium_hidden_intermediate_06414 | Two genes are upregulated by Vaccinia virus and associated with squamous cell carcinoma. One of these genes exhibits a log2 fold change of 1.293 and an adjusted p-value of 0.009806 in cervical adenocarcinoma cell lines (study GSE11238). What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06414","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and associated with squamous cell carcinoma. One of these genes exhibits a log2 ... | |
medium_hidden_intermediate_06416 | Pegivirus C is reported to downregulate a specific gene, which in turn enables ATP-dependent activity acting on DNA. Experimental data from a study on peripheral blood mononuclear cells (GSE131504) indicates that this gene has a log2 fold change of -2.122 and an adjusted p-value of 0.0004294. Which protein is encoded b... | TATA-binding protein-associated factor 172 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06416","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn enables ATP-dependent activity acting on DNA. Experim... | |
medium_hidden_intermediate_06417 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), a gene upregulated by Influenza A virus and known to enable RNA binding showed a log2 fold change of approximately 2.11 and an adjusted p-value of 0.0001424. Which disease is associated with this gene as a biomarker? | non-small cell lung carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06417","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), a gene upregulated by Influenza A virus and known t... | |
medium_hidden_intermediate_06418 | Two genes are downregulated by Vaccinia virus and interact with YWHAB. One of these genes exhibits a log2 fold change of -1.179 and an adjusted p-value of 0.01146 in cervical adenocarcinoma cell lines. Which disease is associated with this specific gene? | xeroderma pigmentosum | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06418","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Vaccinia virus and interact with YWHAB. One of these genes exhibits a log2 fold change of -1.... | |
medium_hidden_intermediate_06420 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in retrograde transport at the Trans-Golgi-Network. Evidence for one such gene reports a log2 fold change of 1.025 and an adjusted p-value of 6.435e-05. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06420","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in retrograde transport at the Tr... | |
medium_hidden_intermediate_06421 | Rhinovirus A infection leads to the downregulation of certain genes whose protein products are located in the perinuclear region of the cytoplasm. One such gene exhibits a log2 fold change of -1.531 and an adjusted p-value of 0.01608 in cytotoxic T-lymphocytes. Which protein is encoded by this specific gene? | Guanylate-binding protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06421","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection leads to the downregulation of certain genes whose protein products are located in the perinuclear re... | |
medium_hidden_intermediate_06422 | Hepacivirus C upregulates a gene that participates in lipid metabolism. In a study of hepatocytes (GSE132606), one such gene showed a log2 fold change of 1.422 and an adjusted p-value of 0.001507. Which protein is encoded by this specific gene? | Constitutive coactivator of peroxisome proliferator-activated receptor gamma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06422","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in lipid metabolism. In a study of hepatocytes (GSE132606), one such gene... | |
medium_hidden_intermediate_06423 | In a study of macrophages (GSE108897), a gene is identified that is upregulated by Human immunodeficiency virus 1 and enables protein kinase activity. This specific gene exhibits a log2 fold change of 1.083 and an adjusted p-value of 0.001169. Which disease is associated with this gene? | nephrotic syndrome, type 9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06423","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified that is upregulated by Human immunodeficiency virus 1 and enable... | |
medium_hidden_intermediate_06425 | Muscle neoplasms are localized to an anatomical structure that is a mesoderm-derived structure. One such structure is described as a fibromuscular tubular tract leading from the uterus to the exterior of the body in female placental mammals and marsupials, or to the cloaca in female birds, monotremes, and some reptiles... | internal female genitalia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06425","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Muscle neoplasms are localized to an anatomical structure that is a mesoderm-derived structure. One such structure is descri... | |
medium_hidden_intermediate_06426 | Pegivirus C is reported to downregulate a gene that is involved in mitochondrial fusion. In a study of peripheral blood mononuclear cells (GSE131504), one such gene showed a log2 fold change of approximately -1.203 and an adjusted p-value of 0.004602. Which protein is encoded by this specific gene? | Probable tRNA(His) guanylyltransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06426","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in mitochondrial fusion. In a study of peripheral blood mono... | |
medium_hidden_intermediate_06428 | Pegivirus C is reported to downregulate a gene that enables protein serine/threonine kinase activity. In a study (GSE131504) involving peripheral blood mononuclear cells, one such gene showed a log2 fold change of approximately -1.25 and an adjusted p-value of 0.0002114. Which cell type is this specific gene enriched i... | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06428","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that enables protein serine/threonine kinase activity. In a study (GSE131504)... | |
medium_hidden_intermediate_06429 | Rhinovirus A infection is associated with the upregulation of certain genes that are enriched in basophils. One such gene exhibits a log2 fold change of approximately 1.122 and an adjusted p-value of 0.006939 in cytotoxic T-lymphocytes. Which protein is encoded by this specific gene? | Scaffold attachment factor B2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06429","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A infection is associated with the upregulation of certain genes that are enriched in basophils. One such gene ex... | |
medium_hidden_intermediate_06431 | Hepacivirus C upregulates a gene that is involved in mitochondrial large ribosomal subunit assembly. Evidence for one such gene reports a log2 fold change of 1.015 and an adjusted p-value of 0.00293. Which protein is encoded by that gene? | Mitochondrial ribosome-associated GTPase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06431","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that is involved in mitochondrial large ribosomal subunit assembly. Evidence for one such g... | |
medium_hidden_intermediate_06432 | Pegivirus C is reported to downregulate a gene that participates in the synthesis of substrates in N-glycan biosynthesis. Evidence from a study on peripheral blood mononuclear cells indicates that this gene has a log2 fold change of -2.378 and an adjusted p-value of 0.006992. Which disease is associated with this gene? | kidney cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06432","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that participates in the synthesis of substrates in N-glycan biosynthesis. Ev... | |
medium_hidden_intermediate_06435 | Cardiovirus A upregulates a gene that is located in the membrane. Evidence for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of approximately 1.211 and an adjusted p-value of 0.03161. Which disease is associated with this gene? | polyarticular arthritis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06435","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A upregulates a gene that is located in the membrane. Evidence for this gene in a cervical adenocarcinoma cell l... | |
medium_hidden_intermediate_06436 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in turn interacts with STK4. This gene exhibited a log2 fold change of -1.328 and an adjusted p-value of 0.01069. Which protein is encoded by this gene? | Fascin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06436","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 was found to downregulate a specific gene, which in tu... | |
medium_hidden_intermediate_06437 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Surfactant metabolism. Experimental data for this gene reports a log2 fold change of approximately 2.04 and an adjusted p-value of 0.0175. Which protein is encoded by this gene? | P2Y purinoceptor 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06437","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in Surfactant metabolism. Ex... | |
medium_hidden_intermediate_06438 | Two genes are downregulated by Pegivirus C and interact with HIST1H3A. One of these genes exhibits a log2 fold change of -1.631 and an adjusted p-value of 0.002019 in peripheral blood mononuclear cells. Which disease is associated with this specific gene? | Hengel-Maroofian-Schols syndrome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06438","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and interact with HIST1H3A. One of these genes exhibits a log2 fold change of -1.... | |
medium_hidden_intermediate_06439 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and participates in Hemostasis. This specific gene exhibits a log2 fold change of approximately 1.464 and an adjusted p-value of approximately 0.00035. Which protein is encoded by this gene? | Chitinase domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06439","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and participates in Hem... | |
medium_hidden_intermediate_06440 | Two genes are upregulated by Vaccinia virus and associated with colon carcinoma. One of these genes exhibits a log2 fold change of approximately 3.67 and an adjusted p-value of approximately 2.24e-11 in cervical adenocarcinoma cell lines. Which biological process is this specific gene involved in? | protein O-linked glycosylation | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06440","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and associated with colon carcinoma. One of these genes exhibits a log2 fold cha... | |
medium_hidden_intermediate_06441 | Pegivirus C is reported to downregulate a specific gene, which in turn interacts with SNRNP70. Experimental data for this intermediate gene in peripheral blood mononuclear cells (from study GSE131504) shows a log2 fold change of approximately -1.628 and an adjusted p-value of 0.00012. Which protein is encoded by this g... | Zinc finger RNA-binding protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06441","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn interacts with SNRNP70. Experimental data for this in... | |
medium_hidden_intermediate_06442 | Zika virus downregulates a gene that is located in the endosome membrane. Evidence for this gene reports a log2 fold change of -1.993 and an adjusted p-value of 0.04083. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06442","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the endosome membrane. Evidence for this gene reports a log2 fold change ... | |
medium_hidden_intermediate_06443 | Zika virus downregulates a specific gene that enables protein tyrosine phosphatase activity. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -2.70 and an adjusted p-value of 0.016. Which disease is associated with this gene? | glioblastoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06443","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that enables protein tyrosine phosphatase activity. Experimental data for this gene... | |
medium_hidden_intermediate_06444 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection leads to the downregulation of certain genes. One such gene is enriched in plasmacytoid dendritic cells and exhibits a log2 fold change of approximately -1.027 with an adjusted p-value of 1.1e-07. Which protein is encod... | Solute carrier family 33 member 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06444","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection leads to the downregula... | |
medium_hidden_intermediate_06445 | Zika virus infection leads to the downregulation of certain genes involved in SLC-mediated transmembrane transport. One such gene exhibits a log2 fold change of approximately -1.08 and an adjusted p-value of 0.029. Which protein is encoded by this specific gene? | Anion exchange protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06445","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection leads to the downregulation of certain genes involved in SLC-mediated transmembrane transport. One such... | |
medium_hidden_intermediate_06448 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to upregulate a specific gene that participates in the Antimicrobial peptides pathway. This gene exhibited a log2 fold change of 3.648 and an adjusted p-value of 0.04924. Which protein is encoded by this gene? | Defensin beta 4A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06448","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_06449 | Hepacivirus C is reported to downregulate a gene that participates in the metabolism of steroids. Evidence for this specific gene shows a log2 fold change of -2.147 and an adjusted p-value of 0.0007022. In which cell type is this gene enriched? | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06449","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to downregulate a gene that participates in the metabolism of steroids. Evidence for this specific... | |
medium_hidden_intermediate_06450 | Zika virus downregulates a specific gene, which in turn interacts with the protein TCEB1. Transcriptomic data from glioma stem cells (study GSE114907) indicates that this gene has a log2 fold change of approximately -1.28 and an adjusted p-value of 0.0028. Which protein is encoded by this gene? | Amyloid protein-binding protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06450","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with the protein TCEB1. Transcriptomic data from glioma st... | |
medium_hidden_intermediate_06451 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the positive regulation of peptidyl-tyrosine phosphorylation. Evidence for one such gene reports a log2 fold change of 1.803 and an adjusted p-value of 0.04873. Which protein is encoded by that gene? | B-cell scaffold protein with ankyrin repeats | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06451","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the positive regulation of pept... | |
medium_hidden_intermediate_06452 | Human immunodeficiency virus 1 downregulates a specific gene, which is enriched in memory B cells. Experimental data for this gene in macrophages (from study GSE108897) reports a log2 fold change of approximately -3.80 and an adjusted p-value of 0.0122. Which protein interacts with this gene product? | NOLC1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06452","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a specific gene, which is enriched in memory B cells. Experimental data for thi... | |
medium_hidden_intermediate_06454 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Platelet degranulation. Experimental data for this gene shows a log2 fold change of -1.183 and an adjusted p-value of 0.03837. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06454","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and participates in Platelet degranulation.... | |
medium_hidden_intermediate_06455 | Two genes are upregulated by Human immunodeficiency virus 1 and enriched in intermediate monocytes. One of these genes exhibits a log2 fold change of approximately 4.20 and an adjusted p-value of approximately 0.00089 in macrophages. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06455","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and enriched in intermediate monocytes. One of these genes exhib... | |
medium_hidden_intermediate_06456 | Zaire ebolavirus upregulates a gene that is located in the mitochondrion. In a study of retinal pigment epithelium cells (GSE100839), one such gene showed a log2 fold change of approximately 1.05 and an adjusted p-value of 0.0001278. Which protein is encoded by this specific gene? | Acyl-coenzyme A synthetase ACSM5, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06456","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus upregulates a gene that is located in the mitochondrion. In a study of retinal pigment epithelium cells (GS... | |
medium_hidden_intermediate_06457 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and participates in the M Phase. Evidence for this gene reports a log2 fold change of approximately 1.85 and an adjusted p-value of 0.0009875. Which protein is encoded by this gene? | Histone H2B type 1-C/E/F/G/I | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06457","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and participat... | |
medium_hidden_intermediate_06458 | Zika virus downregulates a specific gene, which in turn binds to ZNF143. Experimental data for this intermediate gene in glioma stem cells (study GSE114907) reports a log2 fold change of -1.067 and an adjusted p-value of 0.0259. Which protein interacts with this intermediate gene? | EAF1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06458","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn binds to ZNF143. Experimental data for this intermediate gene in gli... | |
medium_hidden_intermediate_06459 | In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and its product enables GTP binding. The experimental data for this gene reports a log2 fold change of 1.252 and an adjusted p-value of 0.01241. Which protein is encoded by this gene? | GTP-binding protein Di-Ras1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06459","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Severe acute respiratory syndrome-related coronavirus infection, a specific gene is upregulated and its produc... | |
medium_hidden_intermediate_06461 | Zika virus downregulates a gene that subsequently interacts with RAC1. Experimental data from glioma stem cells (study GSE114907) indicates that this gene has a log2 fold change of -1.690 and an adjusted p-value of 0.01368. Which protein is encoded by this gene? | TBC1 domain family member 10B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06461","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that subsequently interacts with RAC1. Experimental data from glioma stem cells (study GSE11... | |
medium_hidden_intermediate_06462 | Measles morbillivirus upregulates a gene that participates in the process 'BMAL1:CLOCK,NPAS2 activates circadian expression'. Evidence for this gene in study GSE131840 reports a log2 fold change of approximately 1.61 and an adjusted p-value of approximately 0.024. Which protein is encoded by this gene? | F-box-like/WD repeat-containing protein TBL1XR1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06462","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that participates in the process 'BMAL1:CLOCK,NPAS2 activates circadian expression'... | |
medium_hidden_intermediate_06463 | Zika virus downregulates a specific gene that is involved in the proteasome-mediated ubiquitin-dependent protein catabolic process. Transcriptomic data from glioma stem cells indicates this gene has a log2 fold change of -1.529 and an adjusted p-value of 0.02364. Which cell type is enriched for this gene? | mucosal-associated invariant T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06463","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that is involved in the proteasome-mediated ubiquitin-dependent protein catabolic p... | |
medium_hidden_intermediate_06465 | Human betaherpesvirus 5 upregulates a gene that is located in the extracellular matrix. Evidence for one such gene reports a log2 fold change of 2.991 and an adjusted p-value of 0.004008. Which disease is associated with this gene as a biomarker? | stroke disorder | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06465","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that is located in the extracellular matrix. Evidence for one such gene reports a... | |
medium_hidden_intermediate_06466 | Zika virus downregulates a gene that enables small GTPase binding. In glioma stem cells, one such gene exhibits a log2 fold change of -1.811 and an adjusted p-value of 0.03612. Which protein is encoded by this gene? | Granule associated Rac and RHOG effector protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06466","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that enables small GTPase binding. In glioma stem cells, one such gene exhibits a log2 fold ... | |
medium_hidden_intermediate_06468 | Two genes are identified as markers for specific fetal germ cell types and are both involved in protein ubiquitination. One of these genes forms a complex with Cullin5 that ubiquitylates Rap2. Which cell type is enriched for the gene that exhibits this specific biochemical activity? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06468","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are identified as markers for specific fetal germ cell types and are both involved in protein ubiquitination. One ... | |
medium_hidden_intermediate_06470 | Hepacivirus C upregulates a gene that subsequently binds to ELOB. Experimental data for this intermediate gene reports a log2 fold change of 1.069 and an adjusted p-value of 0.02454. Which molecular function is enabled by this gene? | ubiquitin-like ligase-substrate adaptor activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06470","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that subsequently binds to ELOB. Experimental data for this intermediate gene reports a log... | |
medium_hidden_intermediate_06471 | Two genes are structurally linked to Pegivirus C via a 'downregulates' relationship and subsequently to serine-type endopeptidase activity via an 'enables' relationship. One of these genes is associated with experimental data showing a log2 fold change of -1.317 and an adjusted p-value of 0.04285. Which gene interacts ... | SERPINB6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06471","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Pegivirus C via a 'downregulates' relationship and subsequently to serine-type endopept... | |
medium_hidden_intermediate_06472 | A gene is downregulated by Hepacivirus C and enriched in naive B cells. Experimental data for this gene reports a log2 fold change of -1.091 and an adjusted p-value of 0.04731. Which protein is encoded by this gene? | NF-kappa-B inhibitor delta | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06472","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Hepacivirus C and enriched in naive B cells. Experimental data for this gene reports a log2 fold ... | |
medium_hidden_intermediate_06475 | In a study of cervical adenocarcinoma cell lines (GSE122967), a gene is identified as being downregulated by Cardiovirus A and serving as a biomarker for major depressive disorder. This specific gene exhibits a log2 fold change of -1.140 and an adjusted p-value of 0.01358. Which protein is encoded by this gene? | DNA damage-inducible transcript 4 protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06475","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), a gene is identified as being downregulated by Cardiovirus A a... | |
medium_hidden_intermediate_06477 | Human alphaherpesvirus 1 upregulates a gene that participates in protein repair. Evidence for one such gene reports a log2 fold change of 1.022 and an adjusted p-value of 0.01348. Which disease is associated with this gene as a biomarker? | heart failure | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06477","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that participates in protein repair. Evidence for one such gene reports a log2 f... | |
medium_hidden_intermediate_06479 | Zika virus downregulates a specific gene that interacts with TRIM25. In glioma stem cells, this gene exhibits a log2 fold change of approximately -1.49 and an adjusted p-value of 0.0074. Which biological process is this gene involved in? | signal transduction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06479","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that interacts with TRIM25. In glioma stem cells, this gene exhibits a log2 fold ch... | |
medium_hidden_intermediate_06480 | Zika virus downregulates a gene that participates in PI Metabolism. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of approximately -2.95 and an adjusted p-value of 0.0036. Which protein interacts with this specific gene? | RAB9A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06480","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in PI Metabolism. In a study of glioma stem cells (GSE114907), one such ge... | |
medium_hidden_intermediate_06481 | In a study of umbilical vein endothelial cells (GSE119608), a gene is downregulated by Human gammaherpesvirus 8 and participates in the synthesis of substrates in N-glycan biosynthesis. This specific gene exhibits a log2 fold change of -1.851 and an adjusted p-value of 0.04433. Which biological process is this gene inv... | oligosaccharide metabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06481","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of umbilical vein endothelial cells (GSE119608), a gene is downregulated by Human gammaherpesvirus 8 and particip... | |
medium_hidden_intermediate_06483 | Pegivirus C is reported to downregulate a gene that is involved in the regulation of cell shape. Experimental data from a study on peripheral blood mononuclear cells (GSE131504) indicates that this specific gene has a log2 fold change of approximately -1.195 and an adjusted p-value of 0.001466. Which protein interacts ... | ST7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06483","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in the regulation of cell shape. Experimental data from a st... | |
medium_hidden_intermediate_06484 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes involved in the positive regulation of the apoptotic process. One such gene exhibits a log2 fold change of -2.242 and an adjusted p-value of 0.001621. Which protein does this specific gene product bind... | SH3GL2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06484","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of certain genes invol... | |
medium_hidden_intermediate_06485 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in Ub-specific processing proteases. Evidence for this gene shows a log2 fold change of -1.060 and an adjusted p-value of 0.04222. Which protein is encoded by this gene? | Ubiquitin carboxyl-terminal hydrolase 16 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06485","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in Ub-specific processing prote... | |
medium_hidden_intermediate_06486 | Zaire ebolavirus upregulates a gene that subsequently binds to GNB1. Experimental data for this gene in retinal pigment epithelium cells (study GSE100839) show a log2 fold change of approximately 7.72 and an adjusted p-value of 9.056e-05. To which cellular component is this gene product localized? | extracellular region | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06486","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus upregulates a gene that subsequently binds to GNB1. Experimental data for this gene in retinal pigment epit... | |
medium_hidden_intermediate_06488 | In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a gene involved in the antibacterial humoral response. This specific gene exhibited a log2 fold change of approximately 2.075 and an adjusted p-value of 0.004293. Which protein is encoded by this gene? | Ribonuclease K6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06488","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells (GSE11238), Vaccinia virus infection was found to upregulate a gene involved in ... | |
medium_hidden_intermediate_06491 | In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated and participates in mitochondrial protein import. This gene exhibits a log2 fold change of approximately 3.87 and an adjusted p-value of approximately 9.2e-12. Which biological process is this gene involved in? | protein insertion into mitochondrial inner membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06491","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated and participates in... | |
medium_hidden_intermediate_06492 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of specific genes located in the cytosol. One such gene exhibits a log2 fold change of -1.744 and an adjusted p-value of 0.02225. Which biological process is this specific gene involved in? | cytoskeleton organization | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06492","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection leads to the downregulation of specific genes loca... | |
medium_hidden_intermediate_06493 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the regulation of cell differentiation. Experimental data for this gene in a colonic adenocarcinoma cell line (study GSE148729) reports a log2 fold change of -2.676 and an adjusted p-value of 0.04441. Which protein is en... | Testican-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06493","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the regulation of cell d... | |
medium_hidden_intermediate_06494 | Two genes are known to be upregulated by Human immunodeficiency virus 1 and are both associated with plasma cell myeloma. One of these genes exhibits a log2 fold change of approximately 2.58 and an adjusted p-value of 0.000298 in a specific study context. Which disease is linked to this specific gene via a biomarker re... | alveolar rhabdomyosarcoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06494","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are known to be upregulated by Human immunodeficiency virus 1 and are both associated with plasma cell myeloma. On... | |
medium_hidden_intermediate_06496 | Pegivirus C is reported to downregulate a gene that is involved in the post-transcriptional regulation of gene expression. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -1.42 and an adjusted p-value of 0.0112. Which protein is encoded by this s... | Zinc finger CCCH domain-containing protein 10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06496","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is involved in the post-transcriptional regulation of gene expression. I... | |
medium_hidden_intermediate_06497 | A gene is upregulated by Hepacivirus C and enriched in non-classical monocytes. Evidence for this gene reports a log2 fold change of 1.482 and an adjusted p-value of 0.002441. Which disease is connected to this gene through genomic alterations? | inflammatory myofibroblastic tumor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06497","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Hepacivirus C and enriched in non-classical monocytes. Evidence for this gene reports a log2 fold c... | |
medium_hidden_intermediate_06499 | Measles morbillivirus upregulates a gene that interacts with UBE2D3. One such gene exhibits a log2 fold change of 1.136 and an adjusted p-value of 0.002175 in response to the virus. Which disease is associated with this specific gene? | left ventricular noncompaction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06499","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that interacts with UBE2D3. One such gene exhibits a log2 fold change of 1.136 and ... | |
medium_hidden_intermediate_06501 | Zika virus downregulates a gene that participates in Interferon Signaling. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of approximately -1.76 and an adjusted p-value of approximately 0.0357. Which protein is encoded by this specific gene? | 2'-5'-oligoadenylate synthase 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06501","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in Interferon Signaling. In a study of glioma stem cells (GSE114907), one ... | |
medium_hidden_intermediate_06503 | Human immunodeficiency virus 1 upregulates a gene that is involved in neuron differentiation. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately 1.60 and an adjusted p-value of 0.0077. Which protein is encoded by this gene? | Cardiotrophin-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06503","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in neuron differentiation. In a study of macrophages (GSE... | |
medium_hidden_intermediate_06504 | Zika virus downregulates a gene that is located in the apical plasma membrane. Evidence for this gene reports a log2 fold change of -1.024 and an adjusted p-value of 0.03868. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06504","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that is located in the apical plasma membrane. Evidence for this gene reports a log2 fold ch... | |
medium_hidden_intermediate_06506 | Two genes are upregulated by Vaccinia virus and associated with adenoviridae infectious disease. One of these genes exhibits a log2 fold change of 1.981 and an adjusted p-value of 6.294e-06 in cervical adenocarcinoma cell lines. Which disease is linked to this specific gene through genomic alterations? | urinary bladder carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06506","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Vaccinia virus and associated with adenoviridae infectious disease. One of these genes exhibits... | |
medium_hidden_intermediate_06509 | Two genes are downregulated by Vaccinia virus and participate in Signaling by Rho GTPases. One of these genes exhibits a log2 fold change of -3.991 and an adjusted p-value of 0.01042 in cervical adenocarcinoma cell lines. Which cell type is enriched for the gene matching these expression statistics? | naive thymus-derived CD4-positive, alpha-beta T cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06509","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Vaccinia virus and participate in Signaling by Rho GTPases. One of these genes exhibits a log... | |
medium_hidden_intermediate_06510 | In a study of umbilical vein endothelial cells (GSE119608), a gene is downregulated by Human gammaherpesvirus 8 and its product interacts with STK4. This gene exhibits a log2 fold change of -1.320 and an adjusted p-value of 0.0009077. Which protein is encoded by this gene? | PDZ domain-containing protein GIPC1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06510","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of umbilical vein endothelial cells (GSE119608), a gene is downregulated by Human gammaherpesvirus 8 and its prod... | |
medium_hidden_intermediate_06511 | Zika virus downregulates a gene that enables lipid binding. In glioma stem cells, this gene exhibits a log2 fold change of -1.439 and an adjusted p-value of 0.02147. Which protein is encoded by this gene? | Protein kinase C and casein kinase substrate in neurons protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06511","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that enables lipid binding. In glioma stem cells, this gene exhibits a log2 fold change of -... | |
medium_hidden_intermediate_06512 | Vaccinia virus upregulates a gene that is involved in the regulation of DNA-templated transcription. In a study of cervical adenocarcinoma cell lines (GSE11238), one such gene exhibits a log2 fold change of approximately 1.01 and an adjusted p-value of 0.003089. Which protein is encoded by this specific gene? | TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06512","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus upregulates a gene that is involved in the regulation of DNA-templated transcription. In a study of cervical ... | |
medium_hidden_intermediate_06513 | Zika virus upregulates a gene that participates in post-translational protein modification. Experimental data for this gene in glioblastoma multiforme cancer stem cells (study GSE102924) reports a log2 fold change of approximately 1.57 and an adjusted p-value of 0.009756. Which protein does this gene interact with? | SLC2A1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06513","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that participates in post-translational protein modification. Experimental data for this gene ... | |
medium_hidden_intermediate_06515 | In a study of glioma stem cells (GSE114907), a gene is identified as being downregulated by Zika virus and serving as a biomarker for schizophrenia. This specific gene exhibits a log2 fold change of approximately -2.06 and an adjusted p-value of 0.0151. Which protein is encoded by this gene? | PRKC apoptosis WT1 regulator protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06515","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of glioma stem cells (GSE114907), a gene is identified as being downregulated by Zika virus and serving as a biom... | |
medium_hidden_intermediate_06516 | Two distinct drugs are known to interact with both Ketoconazole and Vemurafenib. One of these drugs has a documented interaction profile where Clarithromycin increases its exposure to a clinically minor and likely irrelevant extent, similar to the effect of Ketoconazole. Which disease is the drug exhibiting this specif... | pulmonary arterial hypertension | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06516","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two distinct drugs are known to interact with both Ketoconazole and Vemurafenib. One of these drugs has a documented interac... | |
medium_hidden_intermediate_06517 | Two genes are upregulated by Hepacivirus C and enriched in intermediate monocytes. One of these genes has a reported log2 fold change of 1.309 and an adjusted p-value of 0.02778 in hepatocytes. Which disease is associated with this specific gene as a biomarker? | cerebral infarction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06517","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Hepacivirus C and enriched in intermediate monocytes. One of these genes has a reported log2 fo... | |
medium_hidden_intermediate_06519 | In a study of Hepacivirus C infection in hepatocytes (GSE132606), a specific gene is downregulated by the virus and enables zinc ion binding. This gene exhibits a log2 fold change of approximately -1.347 and an adjusted p-value of 0.003147. Which biological process is this gene involved in? | retinoid metabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06519","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Hepacivirus C infection in hepatocytes (GSE132606), a specific gene is downregulated by the virus and enables ... | |
medium_hidden_intermediate_06521 | Zika virus downregulates a specific gene that participates in Drug ADME. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -1.513 and an adjusted p-value of 0.004275. Which cellular component is this gene located in? | endoplasmic reticulum | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06521","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in Drug ADME. Experimental data for this gene in glioma stem cell... | |
medium_hidden_intermediate_06522 | Two genes are upregulated by Measles morbillivirus and interact with ANLN. One of these genes has a reported log2 fold change of 1.069 and an adjusted p-value of 0.01392 in study GSE131840. Which disease is associated with this specific gene as a biomarker? | colorectal carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06522","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Measles morbillivirus and interact with ANLN. One of these genes has a reported log2 fold chang... | |
medium_hidden_intermediate_06525 | Pegivirus C is reported to downregulate a gene that participates in the metabolism of carbohydrates and carbohydrate derivatives. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -1.335 and an adjusted p-value of 0.008273. Which protein is encoded... | Beta-1,4 N-acetylgalactosaminyltransferase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_06525","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that participates in the metabolism of carbohydrates and carbohydrate derivat... |
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