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medium_hidden_intermediate_07002 | Human immunodeficiency virus 1 downregulates a gene that participates in diseases of glycosylation. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of -1.996 and an adjusted p-value of 0.0162. Which protein is encoded by this gene? | A disintegrin and metalloproteinase with thrombospondin motifs 6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07002","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in diseases of glycosylation. Evidence for this gene i... | |
medium_hidden_intermediate_07004 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to protein serine/threonine kinase activity via an 'enables' relationship. One of these genes is associated with experimental data showing a log2 fold change of -1.254 and an adjusted p-valu... | Serine/threonine-protein kinase PLK2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07004","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_07005 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is involved in host-mediated suppression of symbiont invasion. Evidence for this specific gene reports a log2 fold change of approximately 1.24 and an adjusted p-value of approximately 0.0082. Which protein is encoded by this ... | Tripartite motif-containing protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07005","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that is involved in host-mediated s... | |
medium_hidden_intermediate_07006 | Two genes are downregulated by Human immunodeficiency virus 1 and both enable calcium ion binding. One of these genes exhibits a log2 fold change of -1.650 and an adjusted p-value of 0.02119 in macrophages (study GSE108897). Which disease is associated with this specific gene? | adenoviridae infectious disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07006","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Human immunodeficiency virus 1 and both enable calcium ion binding. One of these genes exhibi... | |
medium_hidden_intermediate_07008 | Zaire ebolavirus infection leads to the upregulation of genes that enable chemokine activity. In a study of retinal pigment epithelium cells (GSE100839), one such upregulated gene exhibited a log2 fold change of 1.745 and an adjusted p-value of 0.04848. Which protein is encoded by this specific gene? | Interleukin-8 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07008","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus infection leads to the upregulation of genes that enable chemokine activity. In a study of retinal pigment ... | |
medium_hidden_intermediate_07015 | Two genes are downregulated by Cardiovirus A and associated with hepatocellular carcinoma. One of these genes exhibits a log2 fold change of approximately -1.161 and an adjusted p-value of 0.01261 in cervical adenocarcinoma cell lines. Which cell type is enriched for the other gene? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07015","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Cardiovirus A and associated with hepatocellular carcinoma. One of these genes exhibits a log... | |
medium_hidden_intermediate_07017 | Zika virus downregulates a specific gene, which in turn interacts with the protein YWHAZ. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of -2.031 and an adjusted p-value of 0.007385. Which protein is encoded by this gene? | CREB-regulated transcription coactivator 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07017","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn interacts with the protein YWHAZ. Experimental data for this gene in... | |
medium_hidden_intermediate_07018 | Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to PARK2 via an 'interacts with' relationship. One of these genes exhibits a log2 fold change of -1.114 and an adjusted p-value of 0.003921 in a specific study. Which cell type is that gene enriched in? | basophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07018","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to PARK2 via an '... | |
medium_hidden_intermediate_07019 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with glioma. One of these genes was reported in a study of bronchial epithelial cells (GSE150819) with a log2 fold change of approximately 1.605 and an adjusted p-value of 0.0423. What molecular function is enabled by ... | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07019","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are associated with glioma. One of th... | |
medium_hidden_intermediate_07020 | In a study of Hepacivirus C infection in hepatocytes (GSE132606), two genes are upregulated by the virus and interact with ZRANB1. One of these genes exhibits a log2 fold change of approximately 1.47 and an adjusted p-value of approximately 0.00043. Which cellular component is the location of this specific gene? | chromosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07020","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Hepacivirus C infection in hepatocytes (GSE132606), two genes are upregulated by the virus and interact with Z... | |
medium_hidden_intermediate_07021 | In the context of Severe acute respiratory syndrome-related coronavirus infection, two genes are upregulated and subsequently interact with VCP. One of these genes exhibits a log2 fold change of approximately 1.20 and an adjusted p-value of 0.002063. Which protein is encoded by this specific gene? | Granzyme K | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07021","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In the context of Severe acute respiratory syndrome-related coronavirus infection, two genes are upregulated and subsequentl... | |
medium_hidden_intermediate_07022 | In a study of peripheral blood mononuclear cells (GSE131504), a gene is identified as being downregulated by Pegivirus C and is known to bind SESN1. This specific gene exhibits a log2 fold change of -1.614 and an adjusted p-value of 0.02703. Which protein is encoded by this gene? | KICSTOR subunit 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07022","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE131504), a gene is identified as being downregulated by Pegivirus C and... | |
medium_hidden_intermediate_07023 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently interacts with BRD4. One such gene exhibits a log2 fold change of 1.377 and an adjusted p-value of 0.003147. Which protein is encoded by this specific gene? | BPTF-associated chromatin complex component 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07023","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently interacts with BR... | |
medium_hidden_intermediate_07024 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a specific gene, which in turn interacts with AURKA. This gene exhibits a log2 fold change of approximately -1.33 and an adjusted p-value of 0.0169. Which protein is encoded by this gene? | Ferritin light chain | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07024","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 downregulates a specific gene, which in turn interacts... | |
medium_hidden_intermediate_07025 | In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection was found to upregulate a specific gene, which in turn interacts with HOMER3. This gene exhibited a log2 fold change of approximately 1.03 and an adjusted p-value of 1.64e-09. Which protein is encoded by this gene? | Abl interactor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07025","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma cell lines (GSE147507), Influenza A virus infection was found to upregulate... | |
medium_hidden_intermediate_07026 | A gene is upregulated by Measles morbillivirus and participates in Signaling by NOTCH. Experimental evidence for this gene reports a log2 fold change of approximately 1.13 and an adjusted p-value of approximately 0.0025. Which protein is encoded by this gene? | Cyclic AMP-responsive element-binding protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07026","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and participates in Signaling by NOTCH. Experimental evidence for this gene r... | |
medium_hidden_intermediate_07027 | Human immunodeficiency virus 1 downregulates a gene that is involved in endosomal transport. In a study of macrophages (GSE108897), one such gene exhibited a log2 fold change of approximately -1.072 and an adjusted p-value of 0.01672. Which protein is encoded by this specific gene? | AP-5 complex subunit mu-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07027","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is involved in endosomal transport. In a study of macrophages (GSE1... | |
medium_hidden_intermediate_07028 | Human immunodeficiency virus 1 downregulates a gene that interacts with PRKN. Evidence for this gene reports a log2 fold change of -1.084 and an adjusted p-value of 0.005979. Which cell type is this gene enriched in? | classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07028","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that interacts with PRKN. Evidence for this gene reports a log2 fold cha... | |
medium_hidden_intermediate_07029 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a specific gene, which in turn interacts with PLK1. Evidence for this gene shows a log2 fold change of approximately -1.12 and an adjusted p-value of 0.0087. Which protein is encoded by this gene? | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07029","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the downregulation of a speci... | |
medium_hidden_intermediate_07030 | BCL2L1 binds to a protein that is involved in the positive regulation of protein-containing complex assembly. Contextual evidence notes that Bcl-xL and Bcl-w, the closest homologues of Bcl-2, bind to a proapoptotic BH3-only protein and inhibit its activity, whereas more distant viral homologues like adenovirus E1B19K a... | Bcl-2-like protein 11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07030","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"BCL2L1 binds to a protein that is involved in the positive regulation of protein-containing complex assembly. Contextual evi... | |
medium_hidden_intermediate_07032 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with BIRC5. Evidence for one such gene reports a log2 fold change of -1.101 and an adjusted p-value of 0.0001696. Which protein is encoded by that gene? | F-box/LRR-repeat protein 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07032","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that interacts with BIRC5. Evidence for one such ... | |
medium_hidden_intermediate_07034 | Two genes are identified as markers of neural stem cells and are both involved in chromatin organization. One of these genes is described as facilitating the assembly of nucleoprotein higher-order structures by bending and looping DNA or by stabilizing underwound DNA. Which disease is associated with this specific gene... | hepatocellular carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07034","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are identified as markers of neural stem cells and are both involved in chromatin organization. One of these genes... | |
medium_hidden_intermediate_07036 | A gene serves as a marker for SLC16A7+ cells and is enriched in regulatory T cells. Evidence for this gene includes a mean expression of 71.48 TPM, a z-score of 3.82, and a fold enrichment of 210.71. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07036","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for SLC16A7+ cells and is enriched in regulatory T cells. Evidence for this gene includes a mean e... | |
medium_hidden_intermediate_07039 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is associated with polyarticular arthritis. Experimental data for this gene reports a log2 fold change of -1.130 and an adjusted p-value of 0.006678. Which protein is encoded by this gene? | Protein JTB | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07039","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is associated with polyarticular arthri... | |
medium_hidden_intermediate_07040 | In a study of non-small cell lung adenocarcinoma, a gene downregulated by Influenza A virus and known to enable identical protein binding was found to have a log2 fold change of -1.197 and an adjusted p-value of 5.916e-05. Which disease is associated with this gene as a biomarker? | lung cancer | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07040","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of non-small cell lung adenocarcinoma, a gene downregulated by Influenza A virus and known to enable identical pr... | |
medium_hidden_intermediate_07041 | Pegivirus C is associated with the downregulation of a gene that participates in platelet activation, signaling, and aggregation. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.047 and an adjusted p-value of 0.001873. Which protein is encoded by this speci... | NADH-cytochrome b5 reductase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07041","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is associated with the downregulation of a gene that participates in platelet activation, signaling, and aggrega... | |
medium_hidden_intermediate_07046 | Human alphaherpesvirus 1 upregulates a gene that is involved in the negative regulation of double-strand break repair via homologous recombination. Experimental data from a monocytic leukemia cell line (study GSE114966) indicates that one such gene has a log2 fold change of 1.247 and an adjusted p-value of 0.004083. Wh... | RAD51 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07046","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that is involved in the negative regulation of double-strand break repair via ho... | |
medium_hidden_intermediate_07047 | In a study of macrophages (GSE108897), a gene is identified as being upregulated by Human immunodeficiency virus 1 and serving as a biomarker for pulmonary fibrosis. This specific gene exhibits a log2 fold change of 2.782 and an adjusted p-value of 0.01358. Which protein is encoded by this gene? | C-C motif chemokine 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07047","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified as being upregulated by Human immunodeficiency virus 1 and servi... | |
medium_hidden_intermediate_07048 | Cardiovirus A is reported to downregulate a specific gene, which is in turn enriched in non-classical monocytes. Experimental data for this gene in a cervical adenocarcinoma cell line (study GSE122967) shows a log2 fold change of approximately -1.13 and an adjusted p-value of approximately 0.0138. Which protein is enco... | Protein PHTF2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07048","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A is reported to downregulate a specific gene, which is in turn enriched in non-classical monocytes. Experimenta... | |
medium_hidden_intermediate_07049 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and enable glycerophospholipid phospholipase A1 activity. One of these genes shows a log2 fold change of approximately 1.77 and an adjusted p-value of approximately 0.0068 in a specific study. Which biological process is this gene involv... | phosphatidylcholine metabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07049","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and enable glycerophospholipid phospholip... | |
medium_hidden_intermediate_07051 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes that participate in metal ion SLC transport. One such gene exhibited a log2 fold change of approximately 1.16 and an adjusted p-value of 0.01578. Which protein is encoded by this specific gene? | Solute carrier family 41 member 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07051","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to upregulate certain genes that partici... | |
medium_hidden_intermediate_07052 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the upregulation of specific genes located in the extracellular matrix. One such gene exhibits a log2 fold change of approximately 1.765 and an adjusted p-value of 0.02366. Which biological process is this specific gene invol... | maintenance of gastrointestinal epithelium | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07052","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection leads to the upregulation of specific ... | |
medium_hidden_intermediate_07053 | Pegivirus C is reported to downregulate a gene that is located in the cell cortex. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of -1.080 and an adjusted p-value of 0.0003674. Which protein is encoded by this specific gene? | CD302 antigen | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07053","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is located in the cell cortex. In a study of peripheral blood mononuclea... | |
medium_hidden_intermediate_07054 | Zika virus downregulates a specific gene that participates in the translation of structural proteins. Experimental data from glioma stem cells (study GSE114907) indicate that this gene has a log2 fold change of approximately -1.20 and an adjusted p-value of approximately 0.031. What molecular function is enabled by thi... | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07054","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in the translation of structural proteins. Experimental data from... | |
medium_hidden_intermediate_07055 | Measles morbillivirus upregulates a gene that is located in the late endosome. Evidence for one such gene reports a log2 fold change of 1.022 and an adjusted p-value of 0.001177. Which protein is encoded by that gene? | Sorting nexin-16 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07055","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is located in the late endosome. Evidence for one such gene reports a log2 fol... | |
medium_hidden_intermediate_07056 | Zika virus infection leads to the downregulation of certain genes that participate in Homology Directed Repair. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of approximately -3.04 and an adjusted p-value of 0.0209. Which protein is encoded by this specific gene? | DNA repair protein RAD52 homolog | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07056","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection leads to the downregulation of certain genes that participate in Homology Directed Repair. In a study o... | |
medium_hidden_intermediate_07058 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for schizophrenia. Experimental data for this gene reports a log2 fold change of approximately 3.355 and an adjusted p-value of 0.009784. Which cellular component is this gene located in? | extracellular space | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07058","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and serves as a biomarker for schizophrenia. ... | |
medium_hidden_intermediate_07061 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is located in the cytoplasmic vesicle. Experimental evidence for this gene reports a log2 fold change of 1.070 and an adjusted p-value of 0.000269. Which disease is associated with this gene through genomic alterations? | hemolytic anemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07061","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and is located in the cytoplasmic vesicle. Ex... | |
medium_hidden_intermediate_07062 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables zinc ion binding. Experimental data for this gene reports a log2 fold change of -1.342 and an adjusted p-value of 0.017. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07062","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and enables zinc ion binding. Experimental ... | |
medium_hidden_intermediate_07064 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the defense response to virus. Evidence for this gene reports a log2 fold change of 1.149 and an adjusted p-value of 0.00602. Which gene interacts with this upregulated gene? | RB1CC1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07064","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the defense response to virus. ... | |
medium_hidden_intermediate_07065 | Two genes are linked to Human immunodeficiency virus 1 via an upregulation relationship and to mammary neoplasms, animal via a biomarker relationship. One of these genes is associated with a log2 fold change of 1.060 and an adjusted p-value of 0.01324. Which protein is encoded by this specific gene? | Breast cancer anti-estrogen resistance protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07065","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Human immunodeficiency virus 1 via an upregulation relationship and to mammary neoplasms, animal via... | |
medium_hidden_intermediate_07068 | Human betaherpesvirus 5 upregulates a specific gene that subsequently binds to JAK1. Experimental data for this gene in dendritic cells (from study GSE101855) reports a log2 fold change of approximately 3.65 and an adjusted p-value of approximately 0.046. Which disease is associated with this gene? | hypersensitivity reaction disease | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07068","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a specific gene that subsequently binds to JAK1. Experimental data for this gene in dend... | |
medium_hidden_intermediate_07069 | A gene is downregulated by Measles morbillivirus and participates in the metabolism of proteins. Experimental evidence for this gene reports a log2 fold change of approximately -1.22 and an adjusted p-value of 0.000798. Which cellular component is this gene located in? | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07069","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Measles morbillivirus and participates in the metabolism of proteins. Experimental evidence for t... | |
medium_hidden_intermediate_07071 | In a study of macrophages (GSE108897), a gene is downregulated by Human immunodeficiency virus 1 and interacts with ATXN1. This gene exhibits a log2 fold change of -1.032 and an adjusted p-value of 0.02546. Which protein is encoded by this gene? | LIM and SH3 domain protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07071","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is downregulated by Human immunodeficiency virus 1 and interacts with ATXN1. T... | |
medium_hidden_intermediate_07072 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in intracellular signal transduction. Experimental data for this gene shows a log2 fold change of -1.170 and an adjusted p-value of 0.03032. Which cellular component is this gene located in? | nucleolus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07072","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in intracellular signal tra... | |
medium_hidden_intermediate_07073 | Two genes are upregulated by Influenza A virus and are enriched in conventional dendritic cells. One of these genes exhibits a log2 fold change of approximately 1.68 and an adjusted p-value of approximately 3.91e-10 in non-small cell lung adenocarcinoma cell lines. Which disease is associated with this specific gene as... | childhood malignant schwannoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07073","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Influenza A virus and are enriched in conventional dendritic cells. One of these genes exhibits... | |
medium_hidden_intermediate_07075 | Two genes are structurally linked to Enterovirus A via downregulation and to ovarian neoplasm via biomarker association. One of these genes exhibits a log2 fold change of approximately -1.164 and an adjusted p-value of 0.001615 in rhabdomyosarcoma cells (study GSE103308). Which protein is encoded by the gene matching t... | Dual specificity protein phosphatase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07075","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Enterovirus A via downregulation and to ovarian neoplasm via biomarker association. One... | |
medium_hidden_intermediate_07076 | Zika virus downregulates a specific gene, which in turn enables protein-folding chaperone binding. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -1.02 and an adjusted p-value of approximately 0.039. Which cellular component is this gene located in? | membrane | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07076","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene, which in turn enables protein-folding chaperone binding. Experimental data for thi... | |
medium_hidden_intermediate_07077 | The gene SCN5A enables a specific molecular function that is a subtype of voltage-gated sodium channel activity involved in cardiac muscle cell action potential. Evidence for this specific function describes the transmembrane transfer of sodium ions by a voltage-gated channel through the plasma membrane of a bundle of ... | membrane depolarization during bundle of His cell action potential | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07077","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"The gene SCN5A enables a specific molecular function that is a subtype of voltage-gated sodium channel activity involved in ... | |
medium_hidden_intermediate_07078 | A gene is downregulated by Zika virus and is enriched in naive B cells. Experimental data for this gene in glioma stem cells (study GSE114907) reports a log2 fold change of approximately -2.22 and an adjusted p-value of approximately 0.02. Which protein is encoded by this gene? | Semaphorin-4B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07078","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Zika virus and is enriched in naive B cells. Experimental data for this gene in glioma stem cells... | |
medium_hidden_intermediate_07079 | Zika virus downregulates a gene whose product is located in the extracellular space. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -1.871 and an adjusted p-value of 0.003906. Which protein is encoded by this specific gene? | Attractin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07079","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene whose product is located in the extracellular space. In a study of glioma stem cells (GSE114... | |
medium_hidden_intermediate_07080 | Human alphaherpesvirus 1 upregulates a gene that is located in the cytoplasm. Evidence for this specific gene reports a log2 fold change of 1.107 and an adjusted p-value of 0.02231. Which protein is encoded by this gene? | SH2B adapter protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07080","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that is located in the cytoplasm. Evidence for this specific gene reports a log2... | |
medium_hidden_intermediate_07082 | Vaccinia virus infection upregulates certain genes whose protein products are located in the peroxisomal matrix. One such gene exhibits a log2 fold change of 1.887 and an adjusted p-value of 2.673e-12 in cervical adenocarcinoma cells. Which protein is encoded by this specific gene? | Enoyl-CoA delta isomerase 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07082","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Vaccinia virus infection upregulates certain genes whose protein products are located in the peroxisomal matrix. One such ge... | |
medium_hidden_intermediate_07083 | Pegivirus C is reported to downregulate a specific gene product that participates in the mitotic cell cycle. In a study of peripheral blood mononuclear cells (GSE131504), this entity exhibited a log2 fold change of approximately -1.255 and an adjusted p-value of 0.003438. Which protein is encoded by this gene? | Nuclear envelope phosphatase-regulatory subunit 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07083","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene product that participates in the mitotic cell cycle. In a study of p... | |
medium_hidden_intermediate_07084 | A gene is downregulated by Primate bocaparvovirus 1 and is enriched in plasmacytoid dendritic cells. Experimental data for this gene reports a log2 fold change of -1.018 and an adjusted p-value of 0.0002079. Which protein is encoded by this gene? | Sushi domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07084","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and is enriched in plasmacytoid dendritic cells. Experimental data for t... | |
medium_hidden_intermediate_07085 | Zika virus infection leads to the downregulation of certain genes that are components of ribonucleoprotein complexes. One such gene exhibits a log2 fold change of -2.351 and an adjusted p-value of 0.005018 in glioma stem cells. Which disease is associated with this specific gene? | intellectual disability, autosomal recessive 56 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07085","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection leads to the downregulation of certain genes that are components of ribonucleoprotein complexes. One su... | |
medium_hidden_intermediate_07086 | In a study of choroid plexus epithelium (GSE157852), a gene downregulated by Severe acute respiratory syndrome-related coronavirus and involved in Sensory Perception exhibits a log2 fold change of -1.451 and an adjusted p-value of 0.0002178. Which disease is associated with this gene through genomic alterations? | dementia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07086","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of choroid plexus epithelium (GSE157852), a gene downregulated by Severe acute respiratory syndrome-related coron... | |
medium_hidden_intermediate_07087 | A gene is downregulated by Primate bocaparvovirus 1 and its product is located in the extracellular exosome. Experimental evidence for this gene reports a log2 fold change of -1.564 and an adjusted p-value of 0.02465. Which protein is encoded by this gene? | Desmocollin-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07087","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Primate bocaparvovirus 1 and its product is located in the extracellular exosome. Experimental ev... | |
medium_hidden_intermediate_07089 | In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to downregulate a specific gene involved in SLC-mediated transmembrane transport. This gene exhibited a log2 fold change of approximately -1.10 and an adjusted p-value of 0.0181. Which protein is encoded by this downregulated gene? | Monocarboxylate transporter 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07089","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of rhabdomyosarcoma cells (GSE103308), Enterovirus A infection was found to downregulate a specific gene involved... | |
medium_hidden_intermediate_07090 | DAZ1 interacts with a protein that enables protein binding. Evidence indicates that this protein and DAZAP2 bind similarly to both DAZ and DAZL1 through the DAZ repeats. Which protein is encoded by the gene corresponding to this interacting partner? | DAZ-associated protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07090","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"DAZ1 interacts with a protein that enables protein binding. Evidence indicates that this protein and DAZAP2 bind similarly t... | |
medium_hidden_intermediate_07091 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene that participates in the integration of energy metabolism. This gene exhibited a log2 fold change of approximately 2.03 and an adjusted p-value of 9.151e-10. Which protein is encoded by this gen... | Transketolase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07091","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_07092 | Measles morbillivirus upregulates a gene that interacts with PTPRF. Experimental data for this gene shows a log2 fold change of 1.708 and an adjusted p-value of 3.218e-05. Which protein is encoded by this gene? | DEP domain-containing protein 1B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07092","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that interacts with PTPRF. Experimental data for this gene shows a log2 fold change... | |
medium_hidden_intermediate_07093 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene was found to be upregulated by the virus and is known to enable receptor ligand activity. This gene exhibited a log2 fold change of approximately 3.19 and an adjusted p-value of 0.028. Which protein is encoded ... | Intercellular adhesion molecule 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07093","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus, a specific gene was found to b... | |
medium_hidden_intermediate_07095 | In a study of Measles morbillivirus infection, two genes are identified as being upregulated by the virus and associated with myocardial infarction. One of these genes exhibits a log2 fold change of approximately 1.22 and an adjusted p-value of 0.0029. What is the protein encoded by this specific gene? | Sentrin-specific protease 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07095","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, two genes are identified as being upregulated by the virus and associated wit... | |
medium_hidden_intermediate_07096 | In a study of foreskin fibroblast cells (GSE111036), Human betaherpesvirus 5 infection was found to downregulate a specific gene that enables glycolipid transfer activity. This gene exhibited a log2 fold change of approximately -1.079 and an adjusted p-value of 0.04918. Which cellular component is this gene located in? | cytosol | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07096","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of foreskin fibroblast cells (GSE111036), Human betaherpesvirus 5 infection was found to downregulate a specific ... | |
medium_hidden_intermediate_07097 | Human betaherpesvirus 5 is known to downregulate certain genes that participate in O-linked glycosylation. One such gene exhibits a log2 fold change of -2.792 and an adjusted p-value of 2.155e-10 in foreskin fibroblast cell lines. What molecular function is enabled by this specific gene? | polypeptide N-acetylgalactosaminyltransferase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07097","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is known to downregulate certain genes that participate in O-linked glycosylation. One such gene exh... | |
medium_hidden_intermediate_07098 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific gene that enables mRNA binding. This gene exhibited a log2 fold change of approximately -1.18 and an adjusted p-value of 0.0235. Which protein is encoded by this gene? | Heterogeneous nuclear ribonucleoprotein L-like | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07098","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific g... | |
medium_hidden_intermediate_07099 | Human betaherpesvirus 5 is known to upregulate certain genes that subsequently bind to UBC. One such gene exhibits a log2 fold change of 2.364 and an adjusted p-value of 0.003384 in a specific study. Which protein is encoded by this gene? | Probable E3 ubiquitin-protein ligase HERC6 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07099","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is known to upregulate certain genes that subsequently bind to UBC. One such gene exhibits a log2 fo... | |
medium_hidden_intermediate_07101 | In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific gene, which in turn participates in vesicle-mediated transport. This gene exhibited a log2 fold change of approximately -1.235 and an adjusted p-value of 0.007458. What molecular function is enable... | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07101","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE122967), Cardiovirus A infection was found to downregulate a specific g... | |
medium_hidden_intermediate_07103 | Zika virus downregulates a gene that participates in SLC-mediated transmembrane transport. In a study of glioma stem cells (GSE114907), one such gene showed a log2 fold change of -1.140 and an adjusted p-value of 0.03597. Which protein is encoded by this gene? | Embigin | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07103","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in SLC-mediated transmembrane transport. In a study of glioma stem cells (... | |
medium_hidden_intermediate_07105 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in O-linked glycosylation. Evidence for this gene reports a log2 fold change of 3.374 and an adjusted p-value of 0.03203. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07105","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in O-linked glycosylation. E... | |
medium_hidden_intermediate_07106 | Human betaherpesvirus 5 is reported to downregulate a gene that participates in Asparagine N-linked glycosylation. In a study of foreskin fibroblast cell lines (GSE111036), one such gene exhibited a log2 fold change of approximately -1.236 and an adjusted p-value of 0.04594. Which protein is encoded by this specific ge... | Vesicle-trafficking protein SEC22c | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07106","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is reported to downregulate a gene that participates in Asparagine N-linked glycosylation. In a stud... | |
medium_hidden_intermediate_07107 | Pegivirus C downregulates a specific gene, which in turn enables protein heterodimerization activity. Transcriptomic data from peripheral blood mononuclear cells (study GSE131504) indicates that this gene has a log2 fold change of approximately -1.33 and an adjusted p-value of 0.0058. Which biological process is this g... | cytoplasmic microtubule organization | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07107","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a specific gene, which in turn enables protein heterodimerization activity. Transcriptomic data fr... | |
medium_hidden_intermediate_07108 | Hepacivirus C infection upregulates certain genes that participate in organelle biogenesis and maintenance. One such gene exhibits a log2 fold change of 3.712 and an adjusted p-value of 0.007711 in hepatocytes. Which protein is encoded by this specific gene? | ATP synthase F(1) complex subunit delta, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07108","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C infection upregulates certain genes that participate in organelle biogenesis and maintenance. One such gene ex... | |
medium_hidden_intermediate_07109 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene involved in the negative regulation of the apoptotic process. This gene exhibited a log2 fold change of approximately 1.713 and an adjusted p-value of 1.085e-05. Which protein is encoded by this... | Cell death regulator Aven | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07109","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_07110 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the cellular response to chemical stress. Evidence for this gene reports a log2 fold change of 1.691 and an adjusted p-value of 0.0004687. Which cellular component is this gene located in? | cytosol | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07110","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and participates in the cellular response to ... | |
medium_hidden_intermediate_07111 | A gene is upregulated by Human gammaherpesvirus 8 and is involved in the regulation of cell population proliferation. Experimental data for this gene reports a log2 fold change of approximately 1.67 and an adjusted p-value of approximately 0.020. Which disease is associated with this gene as a biomarker? | diabetes mellitus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07111","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human gammaherpesvirus 8 and is involved in the regulation of cell population proliferation. Experi... | |
medium_hidden_intermediate_07112 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to DLG4 via a 'binds' relationship. One of these genes has an associated expression profile showing a log2 fold change of approximately -2.98 and an adjusted p-value of approximately 0.047. ... | regulation of AMPA receptor activity | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07112","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_07114 | Enterovirus A is reported to upregulate a gene that participates in glycerophospholipid biosynthesis. In a study of rhabdomyosarcoma cells (GSE103308), one such gene exhibited a log2 fold change of 1.619 and an adjusted p-value of 0.01884. Which disease is associated with this specific gene? | primary myelofibrosis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07114","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to upregulate a gene that participates in glycerophospholipid biosynthesis. In a study of rhabdomy... | |
medium_hidden_intermediate_07116 | In a study of Primate bocaparvovirus 1 infection, a gene is upregulated by the virus and participates in the Immune System. Evidence for this gene shows a log2 fold change of 1.517 and an adjusted p-value of 0.04617. Which gene binds to the entity connected to this upregulated gene? | IL1RN | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07116","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Primate bocaparvovirus 1 infection, a gene is upregulated by the virus and participates in the Immune System. ... | |
medium_hidden_intermediate_07118 | Rhinovirus A downregulates a specific gene that participates in Cytokine Signaling in the Immune system. Experimental data for this gene in cytotoxic T-lymphocytes (from study GSE106475) reports a log2 fold change of approximately -5.04 and an adjusted p-value of approximately 0.00049. Which disease is associated with ... | lupus vulgaris | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07118","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rhinovirus A downregulates a specific gene that participates in Cytokine Signaling in the Immune system. Experimental data f... | |
medium_hidden_intermediate_07119 | Human immunodeficiency virus 1 upregulates a gene that is involved in the defense response to virus. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of 2.200 and an adjusted p-value of 0.006498. Which protein is encoded by this gene? | Interferon-induced transmembrane protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07119","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is involved in the defense response to virus. In a study of macrophag... | |
medium_hidden_intermediate_07121 | Zaire ebolavirus upregulates a gene that participates in post-translational protein modification. In a study of retinal pigment epithelium cells (GSE100839), one such gene showed a log2 fold change of 1.204 and an adjusted p-value of 0.01355. Which protein is encoded by this gene? | UL16-binding protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07121","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus upregulates a gene that participates in post-translational protein modification. In a study of retinal pigm... | |
medium_hidden_intermediate_07122 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene downregulated by Vaccinia virus and involved in post-translational protein modification exhibited a log2 fold change of -4.684 and an adjusted p-value of 0.01592. Which biological process is this specific gene involved in? | protein O-linked glycosylation via mannose | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07122","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene downregulated by Vaccinia virus and involved in post-tra... | |
medium_hidden_intermediate_07124 | RC3H1 interacts with a protein that enables RNA binding. Evidence for this protein states: 'The amino-terminal domain of eIF-4B contains a consensus RNA binding domain present in a number of other RNA binding proteins.' Which disease is associated with this protein as a biomarker? | acute myeloid leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07124","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"RC3H1 interacts with a protein that enables RNA binding. Evidence for this protein states: 'The amino-terminal domain of eIF... | |
medium_hidden_intermediate_07125 | FYN interacts with a specific tyrosine kinase from the Src family, which is capable of protein binding. Experimental evidence indicates that the HIV-1 accessory protein Vif binds specifically to the Src homology 3 (SH3) domain of this kinase. Which protein product is encoded by the gene corresponding to this kinase? | Tyrosine-protein kinase HCK | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07125","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"FYN interacts with a specific tyrosine kinase from the Src family, which is capable of protein binding. Experimental evidenc... | |
medium_hidden_intermediate_07126 | In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and binds to POLR2I. This specific gene exhibits a log2 fold change of 1.296 and an adjusted p-value of 0.002602. Which protein is encoded by this gene? | Negative elongation factor E | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07126","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), a gene is upregulated by Vaccinia virus and binds to POLR2I. Th... | |
medium_hidden_intermediate_07127 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that participates in glycerophospholipid biosynthesis. This specific gene exhibited a log2 fold change of approximately 1.11 and an adjusted p-value of 0.0047. Which protein is encoded by this gene? | Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07127","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that pa... | |
medium_hidden_intermediate_07128 | Human betaherpesvirus 5 downregulates a gene that is involved in the positive regulation of the JNK cascade. Evidence for this gene in foreskin fibroblast cell lines (study GSE130665) reports a log2 fold change of -1.544 and an adjusted p-value of 2.062e-07. Which disease is associated with genomic alterations in this ... | hepatocellular carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07128","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 downregulates a gene that is involved in the positive regulation of the JNK cascade. Evidence for th... | |
medium_hidden_intermediate_07129 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gene, which in turn interacts with RELA. This gene exhibited a log2 fold change of 1.105 and an adjusted p-value of 1.726e-08. Which protein is encoded by this gene? | Histone-arginine methyltransferase CARM1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07129","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a specific gen... | |
medium_hidden_intermediate_07130 | Zika virus upregulates a gene that is enriched in neutrophils. One such gene exhibits a log2 fold change of 2.037 and an adjusted p-value of 0.001245. Which protein is encoded by this gene? | Arrestin domain-containing protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07130","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus upregulates a gene that is enriched in neutrophils. One such gene exhibits a log2 fold change of 2.037 and an adj... | |
medium_hidden_intermediate_07131 | In a study of peripheral blood mononuclear cells (GSE131504), a gene is downregulated by Pegivirus C and binds to TUBB2A. This gene exhibits a log2 fold change of -1.244 and an adjusted p-value of 0.03284. Which protein is encoded by this gene? | Dynein axonemal heavy chain 7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07131","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE131504), a gene is downregulated by Pegivirus C and binds to TUBB2A. Th... | |
medium_hidden_intermediate_07133 | Pegivirus C downregulates a gene that participates in intracellular signaling by second messengers. Evidence for this gene in peripheral blood mononuclear cells (study GSE131504) reports a log2 fold change of -1.616 and an adjusted p-value of 0.03046. Which cellular component is this gene located in? | cytosol | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07133","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C downregulates a gene that participates in intracellular signaling by second messengers. Evidence for this gene i... | |
medium_hidden_intermediate_07137 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in protein deubiquitination. Evidence for this gene reports a log2 fold change of -1.104 and an adjusted p-value of 0.04209. Which protein is encoded by this gene? | Endoribonuclease ZC3H12A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07137","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in protein deubiquitination. Evi... | |
medium_hidden_intermediate_07139 | Human betaherpesvirus 5 upregulates a gene that participates in the metabolism of proteins. Evidence for this gene reports a log2 fold change of 3.176 and an adjusted p-value of 0.003762. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07139","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 upregulates a gene that participates in the metabolism of proteins. Evidence for this gene reports a... | |
medium_hidden_intermediate_07141 | A gene is upregulated by Measles morbillivirus and binds to RPS27A. Experimental data for this gene indicates a log2 fold change of 1.215 and an adjusted p-value of 0.0008284. Which disease is associated with this gene? | Mesothelioma, malignant | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07141","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and binds to RPS27A. Experimental data for this gene indicates a log2 fold ch... | |
medium_hidden_intermediate_07145 | Zika virus downregulates a gene that participates in phospholipid metabolism. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -1.499 and an adjusted p-value of 0.01946. Which disease is associated with this gene? | spastic paraplegia 81, autosomal recessive | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07145","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in phospholipid metabolism. In a study of glioma stem cells (GSE114907), t... | |
medium_hidden_intermediate_07146 | A gene is upregulated by Vaccinia virus and interacts with ATF4. Experimental data for this gene in a cervical adenocarcinoma cell line shows a log2 fold change of approximately 1.82 and an adjusted p-value of approximately 0.0042. In which cell type is this gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07146","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Vaccinia virus and interacts with ATF4. Experimental data for this gene in a cervical adenocarcinom... | |
medium_hidden_intermediate_07147 | In studies of Severe acute respiratory syndrome-related coronavirus infection, certain genes are downregulated and subsequently linked to non-small cell lung carcinoma via genomic alterations. One such gene exhibits a log2 fold change of -1.087 and an adjusted p-value of 0.04057 in bronchial epithelial cells. Which pro... | Inner nuclear membrane protein Man1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07147","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In studies of Severe acute respiratory syndrome-related coronavirus infection, certain genes are downregulated and subsequen... | |
medium_hidden_intermediate_07148 | Hepacivirus C is reported to upregulate a gene that participates in platelet degranulation. One such gene exhibits a log2 fold change of 1.111 and an adjusted p-value of 8.086e-08. Which protein is encoded by this specific gene? | Phosphatase and actin regulator 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_07148","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a gene that participates in platelet degranulation. One such gene exhibits a log2 fo... |
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